Hub : Genes

CHP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.128	0.050	2.5e-07	0.112	NA	0.101	NA	0.107	9.0e-09	NA	5.7e-08	NA	2.1e-08
2	GTEx	Esophagus Mucosa	0.194	0.068	1.2e-07	0.101	NA	0.079	NA	0.089	2.9e-07	NA	5.6e-06	NA	1.4e-06
3	GTEx	Skin Sun Exposed Lower leg	0.062	0.031	5.2e-04	0.038	NA	0.039	NA	0.028	3.8e-04	NA	3.1e-04	NA	2.0e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Allergy or Eczema	21.7	57.2	61.2	-7.1	-7.8	-7.7
Had menopause	15.6	19.4	19.8	-4.4	-4.4	-4.4
Hayfever, allergic rhinitis or eczema	13.8	30.0	36.5	-4.6	-5.7	-6.0
Allergy	13.5	31.0	39.4	4.2	6.0	6.3
Cardiovascular Disease	13.2	43.5	61.3	-5.0	-6.6	-7.8
Vascular/heart problems diagnosed by doctor	13.0	35.3	47.6	4.8	6.0	6.9
Diastolic blood pressure, automated reading	12.2	37.8	50.3	-5.4	-5.8	-7.1
Hypertension (Self-reported)	12.1	33.6	45.8	-4.5	-5.9	-6.8
High blood pressure	11.8	32.8	43.3	-4.6	-5.8	-6.6
Systolic blood pressure, automated reading	10.4	30.1	34.7	-4.8	-5.7	-5.9
Medication: Cholesterol lowering	10.0	15.6	18.5	-3.6	-3.9	-4.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	10.0	11.8	17.1	-4.1	-3.1	-2.9
Ulcerative Colitis	9.7	14.0	18.0	4.2	3.3	3.7
Medication: Atorvastatin	9.5	11.7	16.3	-2.9	-3.2	-4.0
Ulcerative Colitis (UC)	9.4	17.6	25.2	5.0	3.7	3.8
Medication for cholesterol, blood pressure or diabetes	9.0	14.8	20.7	3.0	3.8	4.6
Medication: Blood pressure	9.0	17.1	22.8	-3.3	-4.2	-4.8
Long-standing illness, disability or infirmity	8.6	13.2	19.5	-2.5	-3.7	-4.4
Systolic Blood Pressure	8.5	42.7	57.3	-4.6	-7.0	-7.6
Respiratory disease	8.5	19.0	24.1	-3.8	-4.9	-4.3
Hayfever/allergic rhinitis (self-reported)	8.5	11.3	11.7	-3.3	-3.4	-3.4
Taking other prescription medications	8.0	12.3	17.0	-2.7	-3.5	-4.1
Commuting to job workplace: Cycle	7.9	9.5	10.6	2.9	3.1	3.3
Illnesses of father: Heart disease	7.8	10.9	13.4	-2.6	-3.7	-3.6
High blood pressure (siblings)	7.7	11.0	11.7	-3.4	-3.2	-3.4
Medication: Ramipril	7.6	9.8	14.2	-2.0	-3.3	-3.8
Number of treatments/medications taken	7.4	13.3	19.2	-3.3	-3.1	-4.4
Leg fat percentage (right)	7.2	26.3	35.5	-6.0	-4.1	-5.1
Asthma	7.0	13.7	17.0	-3.1	-4.1	-3.9
Age when periods started (menarche)	6.9	16.7	25.3	2.9	5.0	4.0
Medication: Ventolin 100micrograms inhaler	6.9	8.9	9.9	-2.8	-3.1	-3.0
Number of self-reported non-cancer illnesses	6.9	12.0	16.0	-2.7	-3.5	-4.0
Illnesses of siblings	6.8	9.5	11.6	2.4	3.4	3.4
Asthma (self-reported)	6.6	13.2	16.5	-3.0	-4.1	-3.8
Illnesses of father: None of the above (group 1)	6.5	8.1	9.5	2.4	3.0	3.1
Heart disease (siblings)	6.5	8.0	10.0	-2.3	-3.2	-2.9
Arm fat percentage (right)	6.3	25.0	31.4	-5.6	-4.2	-5.1
Leg fat percentage (left)	6.3	22.8	30.9	-5.6	-3.9	-4.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	6.2	13.1	16.0	-3.4	-3.4	-4.0
Arm fat percentage (left)	6.1	24.4	29.5	-5.4	-4.2	-5.1
Time employed in main current job	5.9	6.8	8.4	2.7	2.9	2.2
Body fat percentage	5.9	23.2	32.6	-5.7	-3.8	-4.8
Birth weight of first child	5.8	10.6	14.4	2.5	3.8	3.3
Lung FVC	5.6	28.6	37.5	-4.0	-6.1	-5.7
Had other major operations	5.5	6.7	9.7	-3.1	-2.2	-2.3
Father’s age at death	5.4	7.2	10.6	1.1	3.1	3.3
Medication for cholesterol	5.3	8.1	11.5	1.9	3.0	3.4
Alcohol drinker status: Never	5.3	6.4	8.9	-2.6	-1.9	-3.0
High cholesterol (Self-reported)	5.2	9.3	11.6	-2.7	-3.0	-3.4
Comparative body size at age 10	5.1	14.2	19.4	-4.4	-3.3	-3.5
Mouth/teeth dental problems: Loose teeth	5.1	6.1	8.1	1.8	2.6	2.8
Height	5.0	96.6	127.7	8.7	11.3	9.3
Exposure to tobacco smoke at home	5.0	5.6	6.9	-2.2	-2.2	-2.6
Pulse wave reflection index	5.0	6.2	7.2	-2.7	-2.1	-2.6
Medication: Omeprazole (e.g. Zanprol)	4.7	5.7	7.2	-2.2	-2.2	-2.7
Trunk fat percentage	4.6	18.5	26.6	-5.2	-3.2	-4.3
Illnesses of father: High blood pressure	4.6	5.7	7.0	-2.2	-2.3	-2.6
Medication: Omeprazole	4.5	5.3	6.9	-2.1	-2.1	-2.6
Medication: Amlodipine	4.3	6.0	10.1	-1.7	-2.2	-3.2
Ovarian Cancer	4.2	5.6	6.5	-2.5	-2.4	-2.2
Ever used hormone-replacement therapy (HRT)	4.2	5.4	5.8	-2.4	-2.3	-2.3
Shortness of breath walking on level ground	4.2	5.0	6.4	-2.5	-1.5	-2.5
Angina (self-reported)	4.2	5.5	6.2	-2.0	-2.5	-2.5
Number of operations (self-reported)	4.2	6.2	9.4	-3.1	-2.0	-2.4
Angina	4.1	5.3	6.1	-2.0	-2.5	-2.5
Standing height	4.1	40.8	57.1	5.2	7.6	6.2
Average weekly spirits intake	4.0	5.0	6.6	1.6	2.4	2.6
Ever had stillbirth, spontaneous miscarriage or termination	4.0	4.2	5.9	-1.4	-2.2	-2.4
Alcohol intake frequency.	3.9	9.2	12.1	-3.0	-2.5	-3.5
Tinnitus: Yes, now most or all of the time	3.9	4.6	6.4	-1.7	-2.1	-2.5
Bipolar Disorder (2018)	3.8	6.0	6.9	2.6	2.3	2.4
Medication: Simvastatin	3.8	5.6	7.0	-2.0	-2.4	-2.6
Osteoporosis (self-reported)	3.8	4.8	6.2	-2.0	-2.5	-2.0
Leg fat mass (right)	3.7	14.2	22.2	-4.7	-2.4	-3.8
Medication: Seretide 50 evohaler	3.6	4.1	5.2	-1.6	-2.2	-2.3
Leg pain on walking	3.5	4.3	6.8	-2.6	-1.4	-2.0
Qualifications: NVQ or HND or HNC or equivalent	3.5	4.2	5.6	2.4	1.9	1.9
Body mass index (BMI)	3.4	14.5	20.0	-4.5	-2.8	-3.9
Medication: Blood pressure	3.4	5.9	8.3	-1.8	-2.5	-2.9
Ever smoked	3.4	5.9	7.1	1.9	2.6	2.7
Irritable Bowel Disease (IBD)	3.3	7.9	10.4	3.2	2.6	2.5
Sitting height	3.3	23.5	34.0	3.6	5.8	4.9
Headache pain in last month	3.3	5.6	7.2	-2.7	-1.6	-2.7
Chest pain or discomfort	3.3	4.7	6.5	-2.0	-1.9	-2.5
Leg fat mass (left)	3.3	13.0	20.4	-4.5	-2.3	-3.6
Neuroticism (2016)	3.2	4.6	6.6	-1.5	-2.3	-2.6
Arm fat mass (right)	3.2	13.4	19.3	-4.4	-2.5	-3.8
Pain type(s) experienced in last month: Hip pain	3.2	4.0	7.2	-2.7	-1.3	-1.8
Medication: Bendroflumethiazide	3.2	4.9	6.2	-1.8	-2.3	-2.5
Pain experienced in last month	3.2	5.4	6.5	2.5	1.9	2.5
Alzheimer’s Disease (in father)	3.1	3.4	3.5	1.9	1.8	1.8
Multivitamins +/- minerals	3.1	3.9	5.0	1.4	2.2	2.2
Medication: Atenolol	3.1	3.9	4.8	-2.2	-1.8	-1.9
Medication: Levothyroxine sodium	3.1	5.3	7.8	-1.9	-2.0	-2.8
Number of live births	3.1	4.4	4.8	-2.2	-1.9	-2.2
Blood White Count	3.0	22.0	33.2	4.1	5.8	4.0
BMI	3.0	17.7	24.2	-4.9	-3.2	-4.3
Fed-up feelings	3.0	5.4	7.1	-2.0	-2.2	-2.7
Ever highly irritable/argumentative for 2 days	3.0	3.6	5.8	-2.4	-1.4	-1.7
Arm fat mass (left)	3.0	12.4	18.2	-4.3	-2.4	-3.6
Commuting to job workplace: Public transport	3.0	3.6	5.2	-1.7	-1.7	-2.3
Lupus	2.9	4.4	6.2	-1.3	-2.3	-2.5
Overall health rating	2.9	6.2	8.9	-2.2	-2.2	-3.0
Pack years of smoking	2.9	4.3	8.1	-2.9	-1.4	-1.7
Pain all over the body in last month	2.8	3.0	3.5	-1.5	-1.9	-1.8
Whole body fat mass	2.8	11.7	19.8	-4.4	-2.0	-3.4
Diabetes diagnosed by doctor	2.8	4.5	6.5	-2.0	-1.8	-2.5
Triglycerides	2.7	4.5	7.3	-1.8	-1.7	-2.7
Trunk fat-free mass	2.7	15.3	27.3	2.3	5.2	3.6
Illnesses of mother	2.7	3.3	6.5	0.4	1.8	2.6
Heart disease (mother)	2.7	3.3	5.5	-1.3	-1.6	-2.4
Medication: Aspirin	2.7	3.5	4.4	-1.9	-1.6	-2.1
Deep venous thrombosis (DVT) (self-reported)	2.7	3.4	6.3	-0.9	-1.8	-2.5
Mean Putamen Volume	2.6	3.0	5.6	-0.9	-1.6	-2.4
Sensitivity / hurt feelings	2.6	4.4	5.7	-1.6	-2.4	-2.2
Townsend deprivation index at recruitment	2.6	3.7	4.5	-2.0	-1.6	-2.1
HDL Cholesterol	2.5	4.2	8.9	1.1	1.6	3.0
Medication: Metformin	2.5	3.5	5.2	-1.8	-1.4	-2.3
Trunk predicted mass	2.5	14.6	26.5	2.2	5.1	3.5
Blood clot in the leg (DVT)	2.5	3.3	6.2	-0.9	-1.7	-2.5
Commuting to job workplace: Walk	2.5	2.7	4.3	1.3	1.5	2.1
Hand grip strength (right)	2.4	6.5	9.2	2.3	3.0	2.2
Diverticular disease/diverticulitis (self-reported)	2.4	2.8	4.4	-1.2	-1.6	-2.1
Medication: Ibuprofen	2.4	2.8	5.6	1.4	2.4	1.0
Ever had prostate specific antigen (PSA) test	2.4	2.7	4.1	1.3	2.0	1.5
Blood Eosinophil Count	2.3	17.9	23.4	-4.8	-4.1	-3.6
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.8	4.4	-1.7	-2.0	-2.1
Average weekly red wine intake	2.3	3.4	5.1	1.7	1.5	2.2
Medication: Aspirin	2.3	3.0	3.5	-1.8	-1.5	-1.9
Body Mass Index (BMI) (2010)	2.2	3.1	3.7	-1.9	-1.7	-1.6
Supplements: Glucosamine	2.2	2.9	4.3	1.1	1.8	2.1
Trunk fat mass	2.2	9.4	16.5	-4.1	-1.6	-3.0
Worrier / anxious feelings	2.2	4.2	6.0	-1.7	-1.9	-2.4
Happiness	2.2	2.7	2.9	1.7	1.6	1.6
Cholesterol lowering medication	2.2	3.3	4.4	-1.4	-1.9	-2.1
Hypothyroidism (self reported)	2.1	4.8	6.6	-2.2	-1.7	-2.6
Pack years adult smoking proportion	2.1	3.2	6.2	-2.5	-1.2	-1.4
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.6	4.6	1.4	2.2	1.0
Chronic bronchitis/emphysema (mother)	2.0	2.4	3.2	-1.5	-1.3	-1.8
Arm predicted mass (right)	2.0	10.5	20.8	1.6	4.6	2.8
Hearing aid user	2.0	2.2	3.0	-1.6	-1.1	-1.7
Medication: Lisinopril	2.0	2.6	4.7	-0.3	-1.7	-2.2
Hypothyroidism/myxoedema (self-reported)	1.9	3.6	4.8	-2.0	-1.5	-2.2
Pulse wave peak to peak time	1.9	2.2	3.1	1.8	0.9	1.7
Whole body fat-free mass	1.9	11.0	20.5	1.8	4.5	3.1
Depressed Affect (Nagel 2018)	1.8	3.7	5.5	-1.2	-2.1	-2.3
Alzheimer’s Disease (including proxy)	1.8	2.6	3.2	1.8	1.8	1.2
Rheumatoid Arthritis	1.8	2.5	4.2	2.1	1.3	1.3
Blood Red Count	1.8	17.6	37.6	1.8	6.1	3.4
Vitamin and mineral supplements	1.8	2.4	3.3	-1.8	-1.5	-1.3
Ever unenthusiastic/disinterested for a whole week	1.8	2.2	4.1	0.7	2.0	1.4
Arm fat-free mass (right)	1.8	9.2	18.0	1.5	4.2	2.7
Whole body water mass	1.8	10.5	19.6	1.7	4.4	3.0
Past tobacco smoking	1.7	3.2	5.2	-1.0	-2.3	-1.8
Lung cancer (father)	1.7	1.9	3.0	1.0	1.7	1.3
Worry too long after embarrassment	1.7	2.9	5.5	-0.5	-1.7	-2.3
Number of children fathered	1.7	1.9	3.1	0.6	1.5	1.8
Health satisfaction	1.7	2.2	3.1	-1.2	-1.4	-1.8
Medication for pain relief, constipation, heartburn	1.7	2.9	5.4	2.3	0.9	1.6
Neck or shoulder pain in last month	1.7	2.5	2.5	-1.6	-1.6	-1.6
Supplements: Fish oil (including cod liver oil)	1.7	2.2	2.9	1.2	1.5	1.7
Eye problems/disorders: Glaucoma	1.6	1.9	2.9	-0.1	-1.7	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	3.2	-1.1	-1.8	-1.5
Neuroticism (Nagel 2018)	1.4	3.4	4.5	-1.1	-2.1	-2.1
Hair/balding pattern: Pattern 2	1.4	1.8	3.3	1.8	1.1	1.0
Arm fat-free mass (left)	1.4	6.9	14.9	0.9	3.9	2.2
Lung FEV1/FVC ratio	1.3	6.4	10.9	-3.3	-0.1	-2.9
Bilateral oophorectomy (both ovaries removed)	1.3	1.6	3.4	0.4	1.8	1.1
High blood pressure (mother)	1.3	1.8	3.9	-0.7	-0.9	-2.0
Medication: Lansoprazole	1.3	1.4	1.7	-1.1	-1.3	-1.2
Birth weight	1.3	2.9	7.3	0.7	2.7	0.9
Pulse rate, automated reading	1.3	4.2	7.3	1.5	2.7	1.8
Had major operations	1.3	1.5	1.7	-1.1	-1.3	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	3.8	1.2	1.9	1.6
Average weekly champagne plus white wine intake	1.3	1.8	2.6	1.2	1.6	1.2
Risk taking	1.3	1.9	3.2	1.8	1.3	0.9
Arm predicted mass (left)	1.3	6.7	15.1	0.7	3.9	2.2
Waist Hip Ratio (WHR)	1.2	5.3	8.8	2.2	3.0	1.5
Diabetes (self-reported)	1.2	1.9	3.2	-1.1	-1.1	-1.8
Neuroticism score	1.2	2.4	4.8	-0.4	-1.5	-2.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.7	7.1	-1.4	-1.5	-2.7
Age at last live birth	1.2	1.7	2.3	1.5	1.3	1.1
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	2.2	1.3	1.5	1.4
Mineral and other dietary supplements	1.2	1.6	2.6	-0.7	-1.3	-1.6
Hand grip strength (left)	1.1	2.9	3.9	1.1	1.9	2.0
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.0	-0.7	-1.1	-1.4
Financial difficulties in last 2 years	1.1	1.4	2.0	-1.4	-0.6	-1.4
Leg fat-free mass (right)	1.1	5.9	10.8	1.2	3.3	2.3
Leg predicted mass (right)	1.1	5.9	10.8	1.2	3.3	2.3
Basal metabolic rate	1.1	6.1	13.2	0.9	3.6	2.1
Coronary Artery Disease (CAD)	1.0	1.1	2.7	-0.4	-1.6	-0.8
Type 2 Diabetes (T2D) (2018)	1.0	2.0	2.6	-1.6	-0.9	-1.6
Medication: Co-codamol	1.0	1.1	2.3	-0.7	-0.8	-1.5
Qualifications: CSEs or equivalent	1.0	1.3	2.9	1.7	0.6	0.9
Pulse wave Arterial Stiffness index	1.0	1.1	1.7	-1.3	-0.4	-1.2
Comparative height size at age 10	1.0	5.5	9.1	1.7	3.0	2.1
Smoking status: Previous	1.0	1.5	2.7	0.5	1.7	1.2
Breast cancer (self-reported)	1.0	1.2	1.9	-1.0	-1.4	-0.9
Maternal smoking around birth	0.9	1.3	2.6	0.9	0.8	1.6
Stomach or abdominal pain in last month	0.9	1.1	1.5	-0.9	-1.0	-1.2
Hearing difficulty/problems with background noise	0.9	1.5	2.8	-0.4	-1.7	-1.2
Mouth/teeth dental problems	0.9	1.4	1.4	-1.2	-1.2	-1.2
Glaucoma (self-reported)	0.9	1.1	1.3	0.9	-1.0	-1.1
Gout (self-reported)	0.9	1.3	1.9	0.7	1.2	1.4
Wheeze or whistling in the chest in last year	0.9	1.6	1.9	-1.4	-1.1	-1.3
Medication: Gliclazide	0.9	1.0	1.5	-1.2	-0.4	-1.2
Average weekly beer plus cider intake	0.9	1.4	1.9	0.9	1.4	1.2
Age started oral contraceptive pill	0.9	1.1	2.3	-0.8	-0.5	-1.5
Smoking Status	0.8	1.9	3.0	0.6	1.7	1.5
Neuroticism	0.8	2.0	3.1	-0.6	-1.6	-1.8
Hair/balding pattern: Pattern 3	0.8	1.1	1.5	-1.1	-1.2	-0.9
Eye problems/disorders: Cataract	0.8	1.0	1.6	-0.8	-1.3	-0.8
Bipolar Disorder or Schizophrenia	0.7	1.7	2.0	1.0	1.4	1.4
Age at First Birth	0.7	1.0	1.5	-0.5	-1.2	-1.1
Waist circumference	0.7	2.5	4.8	-2.2	0.0	-1.7
Hip circumference	0.7	2.9	5.3	-2.3	-0.7	-1.7
Pulse rate	0.7	1.2	2.4	0.9	1.6	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.9	1.4	-0.2	-0.8
Length of working week for main job	0.7	0.8	1.5	0.7	1.2	0.7
Tense / ‘highly strung’	0.7	1.1	1.8	-0.8	-1.4	-1.0
Forced vital capacity (FVC), Best measure	0.7	2.4	4.7	-0.7	-1.5	-2.2
Miserableness	0.7	1.2	2.5	0.1	-1.0	-1.6
Wears glasses or contact lenses	0.7	0.8	2.0	-1.4	-0.7	0.1
Ever taken oral contraceptive pill	0.7	0.8	1.8	1.3	0.4	0.6
Major Depression (MDD)	0.6	0.7	1.6	-1.3	-0.1	-0.7
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.6	1.3	0.9	0.2
Leg fat-free mass (left)	0.6	3.1	7.1	0.3	2.7	1.4
Current tobacco smoking	0.6	0.9	1.3	0.9	0.9	1.1
Leg predicted mass (left)	0.6	3.0	7.0	0.3	2.6	1.4
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	3.7	-1.3	-0.9	-1.9
Prospective memory result	0.6	0.8	2.0	-1.4	-0.5	-0.4
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.0	-0.7	-0.7	-1.4
Loneliness, isolation	0.6	0.8	2.2	0.4	-0.2	-1.5
Depression (Nagel 2018)	0.5	0.7	1.1	0.1	-1.1	-1.0
Crohns Disease (2012)	0.5	0.8	1.1	0.5	1.0	1.1
LDL Cholesterol	0.5	0.7	1.2	0.0	1.1	1.0
Diabetes (father)	0.5	0.6	1.1	-0.4	-0.7	-1.1
Severe depression (siblings)	0.5	0.6	0.8	0.5	0.9	0.8
Nervous feelings	0.5	0.9	2.2	1.5	0.1	0.7
Qualifications: None of the above	0.5	1.0	2.0	-1.4	-0.9	-0.4
Qualifications: A levels/AS levels or equivalent	0.5	1.1	1.8	-0.7	-1.1	-1.3
Impedance of arm (left)	0.5	2.5	5.1	-0.7	-2.3	-1.4
Breastfed as a baby	0.5	0.7	1.2	0.6	0.7	1.1
Hair/balding pattern: Pattern 4	0.5	1.2	2.6	0.3	1.0	1.6
Knee pain experienced in last month	0.5	0.7	1.4	-1.2	-0.5	-0.8
Ever had bowel cancer screening	0.5	0.6	1.5	-0.2	1.2	0.4
Basal cell carcinoma (self-reported)	0.5	0.5	0.9	-0.6	0.9	0.7
Alzheimer’s Disease (in mother)	0.4	0.5	0.9	1.0	0.7	0.1
Hair Pigment	0.4	10.4	15.4	2.7	2.9	3.9
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.1	0.1	-0.6	-1.1
Impedance of arm (right)	0.4	2.1	4.0	-0.8	-2.0	-1.2
Exposure to tobacco smoke outside home	0.4	0.5	1.3	1.1	0.4	0.5
Age at first live birth	0.4	0.8	1.8	1.3	0.7	0.1
Suffer from ‘nerves’	0.4	0.6	1.3	-0.1	-1.1	-0.6
Handedness (chirality/laterality): Left-handed	0.4	0.4	0.6	-0.7	0.5	0.8
Back pain experienced in last month	0.4	0.5	1.2	-1.1	0.3	-0.5
Smoking status: Current	0.4	0.6	1.0	0.5	0.7	1.0
Financial situation satisfaction	0.4	0.4	0.8	-0.9	-0.6	-0.4
Alcohol drinker status: Previous	0.4	0.5	0.9	1.0	0.4	0.6
Schizophrenia vs Biploar Disorder	0.3	0.4	1.1	-1.1	0.0	0.1
Worry (Nagel 2018)	0.3	0.7	1.4	-0.6	-1.2	-0.6
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.9	0.4	0.9	0.4
Blood Platelet Count	0.3	3.0	4.6	-1.4	-1.5	-2.1
Heel T-Score	0.3	2.6	4.5	-1.6	-2.1	-0.8
Medication for hormone replacement therapy	0.3	0.4	0.5	-0.5	-0.7	-0.6
Impedance of leg (right)	0.3	1.4	1.6	-1.1	-1.1	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.6	0.5	-0.5	-0.8
Chronic bronchitis/emphysema (father)	0.3	0.4	0.6	0.2	0.7	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.7	0.3	-0.8	-0.7
Fluid intelligence score	0.3	0.6	1.7	1.3	0.2	-0.2
Weight	0.3	1.6	3.5	-1.9	0.7	-0.9
Falls in the last year	0.3	0.5	0.6	-0.8	-0.7	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.7	0.9	-0.2	0.6
Migraine (self-reported)	0.3	0.4	0.8	0.6	0.9	0.3
Medication: Allopurinol	0.3	0.3	0.7	0.0	0.5	0.9
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.4	-0.7	-0.6	-0.6
Supplements: Vitamin C	0.3	0.3	0.6	0.8	-0.3	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.8	0.6	-0.2	-0.9
Mood swings	0.3	0.5	1.3	-0.1	-0.5	-1.1
Osteoarthritis (self-reported)	0.3	0.4	1.1	-1.0	-0.0	-0.2
Medication: Paracetamol	0.3	0.4	0.6	-0.7	0.7	0.4
Supplements: Calcium	0.3	0.3	0.6	0.8	0.6	0.1
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.3	-0.1	-1.1	-0.4
Reaction Time	0.2	0.4	0.8	-0.3	0.9	0.6
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.7	0.3	-0.8	-0.6
Breast Cancer	0.2	0.5	0.9	0.9	0.7	-0.3
Prostate Cancer	0.2	0.3	0.5	0.7	0.3	0.4
Fasting Glucose	0.2	0.2	0.3	-0.5	-0.5	-0.3
Primary Biliary Cirrhosis	0.2	0.2	0.4	-0.3	-0.6	-0.5
Hearing difficulty/problems: Yes	0.2	0.4	0.6	0.8	-0.5	-0.5
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	-0.5	-0.6	-0.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.5	0.2	-0.2	-0.7
Diabetes (mother)	0.2	0.3	0.5	0.5	0.7	-0.4
Relative age voice broke	0.2	0.3	0.5	0.7	0.7	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.3	0.7	-0.8	-0.6	0.0
Number of incorrect matches in round	0.2	0.4	1.0	1.0	0.4	0.2
Heart attack	0.2	0.3	0.8	0.1	-0.2	-0.9
Alcohol intake versus 10 years previously	0.2	0.2	0.4	-0.1	-0.5	-0.7
Noisy workplace	0.2	0.2	0.4	-0.3	-0.5	-0.6
Medication: Paracetamol	0.2	0.3	0.7	-0.8	0.3	-0.1
Eye problems/disorders: None of the above	0.2	0.3	0.5	0.3	0.7	0.5
Mean time to correctly identify matches	0.2	0.4	0.7	-0.8	0.5	0.4
Illnesses of siblings: Diabetes	0.2	0.3	0.7	-0.1	-0.3	-0.8
Qualifications: nursing, teaching	0.2	0.3	0.5	0.7	0.5	0.2
Guilty feelings	0.2	0.3	1.0	-0.1	-0.1	-1.0
Irritability	0.2	0.3	0.8	0.9	0.3	-0.1
Fractured/broken bones in last 5 years	0.2	0.2	0.3	0.2	0.6	0.5
Myopia	0.2	0.3	0.5	0.5	0.7	0.3
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.7	0.1	-0.4	-0.9
Impedance of whole body	0.2	1.0	2.1	-0.4	-1.4	-0.8
Schizophrenia (2018)	0.1	0.2	0.6	-0.8	-0.0	-0.1
Crohns Disease (2017)	0.1	0.2	0.3	-0.4	-0.3	-0.5
Bipolar Disorder (2011)	0.1	0.1	0.2	0.0	-0.1	-0.4
HbA1C	0.1	0.1	0.3	0.5	0.2	0.2
Schizophrenia (2014)	0.1	0.3	0.9	-0.9	-0.2	0.1
Chronotype (morning person)	0.1	0.2	0.2	-0.4	0.5	0.5
Supplements: Zinc	0.1	0.1	0.2	0.4	0.2	0.1
Average weekly fortified wine intake	0.1	0.2	0.4	-0.2	0.3	0.6
Serious illness, injury or assault to yourself	0.1	0.1	0.2	0.0	0.4	0.2
Alcohol usually taken with meals	0.1	0.2	0.4	-0.3	0.6	0.2
Forced vital capacity (FVC)	0.1	0.3	0.7	-0.2	-0.5	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.5	-0.7	-0.6	0.2
Depression (self-reported)	0.1	0.1	0.2	-0.4	-0.4	0.1
Peak expiratory flow (PEF)	0.1	0.1	0.2	0.2	0.3	-0.5
Loud music exposure frequency	0.1	0.1	0.3	0.3	-0.1	0.5
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	0.2	-0.4	0.4
Number of full brothers	0.1	0.1	0.2	-0.5	0.2	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.4	0.6	0.0	-0.0
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	-0.5	-0.3	0.2
Friendships satisfaction	0.1	0.2	0.2	-0.3	-0.4	-0.5
Ever depressed for a whole week	0.1	0.2	0.5	0.0	0.7	0.2
Tanning	0.0	0.1	0.2	-0.1	-0.4	-0.5
Relative age of first facial hair	0.0	0.0	0.0	0.1	-0.1	-0.2
Impedance of leg (left)	0.0	0.2	0.3	-0.2	-0.6	-0.4
Mouth/teeth dental problems: Dentures	0.0	0.0	0.1	-0.0	0.3	-0.1
Qualifications: College or University degree	0.0	0.1	0.3	0.6	0.1	-0.3
Emphysema/chronic bronchitis	0.0	0.0	0.0	0.1	-0.0	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.1	0.1	-0.0	0.2	-0.3
Number of full sisters	0.0	0.0	0.1	-0.2	-0.0	-0.2
Family relationship satisfaction	0.0	0.1	0.1	-0.1	0.3	0.3
Mother’s age at death	0.0	0.0	0.1	0.3	-0.1	0.1
Unable to work because of sickness or disability	0.0	0.0	0.1	-0.0	0.1	-0.3