Hub : Genes

NUSAP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2010	0.0470	0.0e+00	0.238	0.232	0.228	0.241	0.241	1.3e-28	8.0e-28	2.2e-27	4.6e-29	4.7e-29
2	GTEx	Brain Caudate basal ganglia	0.3120	0.0790	2.1e-09	0.380	NA	0.238	NA	0.403	6.8e-12	NA	1.8e-07	NA	1.1e-12
3	GTEx	Brain Cerebellar Hemisphere	0.2410	0.0750	2.6e-06	0.314	NA	0.204	NA	0.224	8.0e-09	NA	5.9e-06	NA	2.0e-06
4	GTEx	Brain Cerebellum	0.2240	0.0810	3.5e-05	0.231	NA	0.221	NA	0.201	2.0e-07	NA	3.7e-07	NA	1.4e-06
5	GTEx	Brain Cortex	0.4280	0.1100	1.0e-08	0.252	NA	0.258	NA	0.229	1.4e-07	NA	8.7e-08	NA	5.6e-07
6	GTEx	Brain Frontal Cortex BA9	0.3857	0.0893	2.8e-11	0.419	NA	0.422	NA	0.338	2.5e-12	NA	2.0e-12	NA	9.0e-10
7	GTEx	Brain Hippocampus	0.2987	0.1118	1.2e-04	0.246	NA	0.255	NA	0.243	1.7e-06	NA	1.0e-06	NA	2.0e-06
8	GTEx	Brain Hypothalamus	0.2570	0.0890	1.2e-05	0.356	NA	0.249	NA	0.267	3.2e-09	NA	1.5e-06	NA	5.6e-07
9	GTEx	Brain Nucleus accumbens basal ganglia	0.3570	0.0920	1.5e-07	0.315	NA	0.257	NA	0.257	3.6e-09	NA	1.5e-07	NA	1.5e-07
10	GTEx	Brain Putamen basal ganglia	0.3780	0.1030	2.2e-07	0.298	NA	0.269	NA	0.335	8.3e-08	NA	4.2e-07	NA	9.2e-09
11	GTEx	Nerve Tibial	0.1519	0.0536	1.6e-08	0.088	NA	0.149	NA	0.117	8.6e-07	NA	9.8e-11	NA	1.2e-08
12	GTEx	Pituitary	0.1610	0.0700	6.3e-04	0.122	NA	0.154	NA	0.162	5.8e-04	NA	1.1e-04	NA	7.4e-05
13	METSIM	Adipose	0.0335	0.0172	3.3e-03	0.026	0.018	0.013	0.019	0.020	8.4e-05	7.8e-04	4.2e-03	5.4e-04	4.2e-04
14	NTR	Blood	0.0254	0.0091	2.0e-08	0.034	0.027	0.036	0.027	0.037	2.6e-11	4.3e-09	1.2e-11	2.6e-09	4.9e-12
15	TCGA	Kidney Renal Clear Cell Carcinoma	0.0269	0.0201	1.2e-03	0.013	0.018	0.012	NA	0.009	1.2e-02	3.4e-03	1.5e-02	NA	2.9e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15
Bipolar Disorder (2018)	5.2	8.2	11.6	-2.6	-3.0	-2.6	-2.9	-3.0	-3.0	-3.0	-2.9	-3.0	-2.8	-2.7	-3.4	-2.2	-2.6	2.8
Bipolar Disorder or Schizophrenia	0.9	2.3	3.5	-1.3	-1.5	-1.1	-1.4	-1.6	-1.6	-1.6	-1.6	-1.6	-1.7	-1.6	-1.9	-0.9	-1.6	1.4
Depressed Affect (Nagel 2018)	0.4	0.9	1.5	0.5	1.0	1.0	1.0	0.5	1.1	1.1	0.8	1.0	1.1	1.2	1.1	0.9	0.6	-0.7
Depression (Nagel 2018)	0.1	0.2	0.6	0.3	0.5	0.3	0.3	0.1	0.6	0.8	-0.2	0.4	0.2	0.4	0.5	0.3	0.4	-0.0
Intelligence (Savage-Jansen 2018)	0.5	1.4	2.3	1.0	1.2	1.3	1.1	0.3	1.3	1.5	1.4	1.3	0.3	1.2	1.2	0.8	1.5	-1.3
Neuroticism (Nagel 2018)	0.3	0.8	1.8	0.7	0.9	0.9	0.6	0.2	0.8	1.0	1.1	0.9	1.3	1.1	0.9	0.8	0.6	-0.7
Schizophrenia (2018)	0.1	0.2	0.5	0.5	0.4	0.7	0.5	0.3	0.4	0.4	0.3	0.4	0.0	0.2	0.3	0.7	0.1	-0.5
Schizophrenia vs Biploar Disorder	1.8	2.4	3.8	1.5	1.8	1.6	1.9	1.6	1.4	1.1	1.3	1.9	1.3	1.1	1.8	1.5	1.1	-1.8
Worry (Nagel 2018)	0.2	0.3	0.8	0.6	0.6	0.8	0.2	-0.2	0.4	0.9	0.6	0.5	0.9	0.4	0.7	0.5	0.5	-0.2
Alzheimer’s Disease (in mother)	0.2	0.2	1.0	-0.6	-0.2	-0.4	-0.6	-1.0	-0.7	-0.4	0.1	-0.4	-0.1	-0.5	-0.1	-0.6	-0.3	0.5
Alzheimer’s Disease (in father)	4.1	4.5	6.2	-1.4	-2.1	-2.3	-2.2	-2.1	-2.0	-2.3	-1.9	-2.3	-2.5	-1.8	-2.3	-2.1	-2.3	1.7
Alzheimer’s Disease (including proxy)	1.9	2.7	4.2	-1.5	-1.4	-1.7	-1.8	-2.0	-1.8	-1.8	-1.1	-1.8	-1.7	-1.6	-1.6	-1.8	-1.5	1.6
Crohns Disease (2017)	0.1	0.3	0.8	0.2	0.7	0.9	0.7	0.4	0.5	0.2	0.3	0.7	0.3	0.6	0.2	0.5	0.1	-0.5
Irritable Bowel Disease (IBD)	2.8	6.8	10.2	-2.6	-2.4	-2.4	-2.3	-2.5	-2.5	-2.5	-2.6	-2.4	-3.2	-2.8	-2.4	-2.4	-3.0	2.7
Ulcerative Colitis (UC)	9.4	17.5	24.0	-4.0	-4.1	-4.2	-4.0	-4.1	-4.1	-3.8	-4.3	-4.1	-4.9	-4.5	-3.7	-4.0	-4.6	4.2
Major Depression (MDD)	2.9	3.5	6.1	1.6	2.0	2.0	2.4	2.5	1.7	1.8	1.3	1.8	2.1	1.2	2.0	2.2	1.5	-1.1
Reaction Time	0.2	0.4	2.0	0.5	0.7	0.7	1.0	1.4	0.3	0.3	0.1	0.4	0.9	-0.2	0.4	1.0	0.3	-0.0
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.8	0.0	0.2	0.4	0.2	-0.4	0.8	0.8	0.4	0.5	-0.6	0.8	0.7	-0.1	0.9	-0.4
Breast Cancer	0.0	0.1	0.3	-0.3	0.3	0.4	0.5	0.1	0.1	-0.2	0.1	0.1	-0.3	-0.3	-0.0	0.1	-0.5	-0.0
Ovarian Cancer	7.4	9.8	11.5	3.2	3.2	3.1	3.1	3.2	2.9	2.9	3.4	3.2	3.2	3.1	3.0	3.1	3.1	-3.3
Prostate Cancer	0.6	0.8	1.8	-0.9	-0.9	-1.1	-1.1	-0.9	-0.8	-0.9	-0.1	-1.1	-0.2	-0.9	-0.7	-1.0	-1.3	0.6
Age at First Birth	0.1	0.1	1.2	0.4	-0.2	-0.1	0.0	-0.2	0.4	0.3	-0.2	-0.1	-0.6	1.1	-0.0	-0.0	0.1	-0.2
Bipolar Disorder (2011)	0.4	0.4	1.1	-0.2	-0.5	-0.7	-0.7	-0.4	-0.8	-1.0	0.3	-0.5	-0.1	-0.4	-0.7	-0.6	-1.1	-0.0
Body Mass Index (BMI) (2010)	3.2	4.4	5.7	1.7	2.4	2.2	2.1	1.7	2.0	2.2	2.0	2.2	2.4	2.0	2.2	2.0	2.3	-2.0
Coronary Artery Disease (CAD)	0.1	0.1	0.3	0.3	-0.0	0.0	-0.0	0.2	0.5	0.5	0.2	0.2	-0.1	0.5	0.3	-0.0	0.3	-0.3
Crohns Disease (2012)	0.1	0.1	0.4	-0.4	-0.1	0.1	-0.0	-0.6	-0.3	-0.4	-0.3	-0.0	-0.2	-0.4	-0.5	-0.0	-0.3	-0.0
Mean Putamen Volume	0.7	0.8	2.0	0.6	0.7	0.9	1.0	0.9	1.1	0.9	0.7	1.0	0.6	1.4	1.3	0.6	0.1	-1.0
Fasting Glucose	0.1	0.1	0.3	-0.3	-0.1	-0.2	-0.4	-0.5	-0.2	0.1	-0.0	-0.2	0.2	-0.2	0.1	-0.5	0.6	0.3
HbA1C	0.1	0.1	0.4	-0.1	-0.2	-0.4	-0.3	-0.3	-0.4	-0.3	0.0	-0.3	-0.1	0.0	-0.2	-0.0	-0.7	0.3
HDL Cholesterol	1.4	2.3	4.3	-1.1	-1.4	-1.4	-1.3	-2.1	-1.2	-1.2	-1.8	-1.4	-1.9	-1.9	-1.3	-1.2	-1.5	1.7
LDL Cholesterol	0.1	0.1	0.6	-0.8	-0.2	-0.2	-0.1	0.0	-0.1	-0.2	-0.4	-0.4	-0.5	-0.5	-0.2	-0.2	0.1	0.7
Lupus	1.4	2.1	4.4	1.1	1.3	1.5	1.0	1.1	1.3	1.5	2.1	1.5	1.7	1.7	1.4	1.0	1.0	-1.9
Neuroticism (2016)	2.5	3.6	5.9	1.6	2.0	1.9	1.8	1.9	1.6	1.9	2.4	1.8	2.2	1.7	2.4	1.8	1.2	-1.7
Primary Biliary Cirrhosis	0.2	0.3	0.7	0.1	0.5	0.5	0.6	0.7	0.6	0.4	0.6	0.7	0.4	0.5	0.7	0.2	0.3	-0.8
Rheumatoid Arthritis	2.2	3.0	4.4	-1.9	-1.8	-1.6	-1.8	-1.8	-1.7	-1.4	-1.9	-1.6	-2.1	-1.7	-1.6	-1.9	-1.7	1.7
Schizophrenia (2014)	0.1	0.3	0.9	0.5	0.5	0.8	0.6	0.3	0.2	0.4	0.5	0.4	-0.0	0.4	0.2	0.9	0.5	-0.6
Triglycerides	2.6	4.2	8.1	1.5	2.0	2.0	1.9	2.9	2.1	1.9	2.2	1.9	2.2	2.2	1.8	1.4	2.1	-2.2
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.9	-0.9	-0.3	-0.4	-0.6	-0.4	-0.7	-0.4	-0.3	-0.6	-0.4	-0.8	-0.7	-0.5	-0.1	0.5
Ulcerative Colitis	8.6	12.4	16.9	-3.3	-3.6	-3.3	-3.3	-3.6	-3.3	-3.3	-4.0	-3.4	-4.1	-3.7	-3.4	-3.2	-3.7	3.6
Blood Eosinophil Count	3.7	28.8	36.8	5.3	5.6	5.2	5.3	5.1	5.6	6.1	5.2	5.7	5.1	5.0	5.7	5.1	5.3	-5.2
Blood Platelet Count	0.3	2.9	4.5	1.5	1.7	1.9	2.0	2.1	1.7	1.4	1.0	1.6	2.0	2.1	1.6	1.8	1.4	-1.3
Blood Red Count	0.9	8.6	17.2	-3.2	-2.5	-3.5	-2.3	-0.9	-3.4	-4.2	-1.6	-3.3	-2.9	-3.7	-3.4	-2.6	-1.9	3.0
Blood White Count	1.9	14.0	23.4	-4.2	-3.5	-3.4	-3.2	-2.4	-4.4	-4.8	-3.3	-3.9	-3.3	-4.3	-4.2	-3.1	-3.6	3.5
Heel T-Score	0.5	4.3	7.8	2.8	2.0	1.9	1.8	0.7	1.7	2.1	1.1	2.4	2.2	2.5	2.1	2.1	2.4	-2.2
BMI	3.3	19.0	23.7	4.0	4.8	4.2	4.6	3.9	4.0	3.8	4.6	4.5	4.7	4.9	4.3	4.6	4.3	-4.1
Height	5.6	107.6	139.2	-10.9	-10.4	-11.8	-10.5	-8.9	-10.0	-11.0	-7.8	-11.4	-10.5	-10.9	-10.6	-11.0	-8.8	10.3
Waist Hip Ratio (WHR)	0.6	2.6	6.9	-1.8	-1.2	-1.4	-1.3	0.2	-2.0	-2.3	-0.9	-1.7	-0.3	-2.6	-1.9	-1.3	-2.1	1.2
Systolic Blood Pressure	2.7	13.5	29.7	4.0	3.0	3.6	2.6	3.6	3.7	3.2	4.2	3.7	3.7	5.5	3.5	2.3	2.0	-4.9
Smoking Status	0.2	0.5	1.7	-0.9	-0.2	-0.8	-0.6	-0.2	-0.9	-1.1	0.6	-0.5	0.5	-1.3	-0.4	-0.4	-1.1	0.2
Allergy or Eczema	16.7	43.9	57.0	6.6	6.6	6.5	6.2	5.7	7.4	7.2	7.5	6.7	6.0	7.6	6.8	5.6	5.7	-6.8
Cardiovascular Disease	5.9	19.5	31.3	4.4	3.9	4.5	4.2	4.9	4.8	4.1	4.4	4.5	4.7	5.6	4.4	3.5	2.5	-5.1
Hypothyroidism (self reported)	1.4	3.1	5.2	1.7	1.6	1.5	1.5	1.8	2.0	1.7	2.2	1.7	2.3	1.9	1.8	1.7	1.4	-1.8
Respiratory disease	8.2	18.2	22.7	4.0	4.4	4.5	4.0	3.7	4.6	4.7	4.8	4.5	4.0	4.5	4.3	4.0	3.5	-4.3
Type 2 Diabetes (T2D) (2018)	2.3	4.2	9.2	1.5	2.3	2.1	2.4	3.0	1.6	1.6	2.0	2.3	2.7	1.4	1.9	2.1	0.9	-2.0
Lung FEV1/FVC ratio	2.0	10.1	25.5	2.4	3.4	2.7	3.3	5.0	2.0	2.1	3.8	2.9	3.8	2.2	3.3	3.4	3.3	-2.6
Lung FVC	1.6	8.0	21.2	3.4	2.2	2.6	2.3	1.8	3.4	2.9	3.4	2.6	1.8	4.6	2.5	2.1	2.2	-3.1
Neuroticism	0.3	0.7	1.6	0.5	0.9	0.8	0.7	0.1	1.0	1.1	0.9	0.9	1.2	0.9	1.3	0.6	0.5	-0.6
Chronotype (morning person)	0.3	0.6	1.7	-0.4	-0.6	-0.7	-0.7	-0.9	-0.7	-1.3	-0.7	-1.0	-1.1	-0.5	-0.6	-0.6	-0.9	0.5
Hair Pigment	0.2	6.8	12.2	-1.9	-2.2	-2.6	-2.4	-2.7	-3.0	-2.8	-2.4	-2.7	-2.6	-3.5	-2.0	-2.3	-2.6	2.9
Tanning	0.0	0.1	0.6	-0.1	-0.3	0.2	0.0	0.0	-0.0	-0.0	-0.8	-0.2	-0.1	-0.1	-0.6	0.4	0.4	0.4
Hand grip strength (left)	1.4	3.7	6.0	-1.9	-2.0	-2.5	-2.2	-1.7	-1.9	-2.2	-1.4	-2.2	-1.9	-1.9	-1.9	-2.1	-1.3	1.5
Number of treatments/medications taken	4.5	8.1	11.4	2.4	2.9	3.1	2.9	3.3	2.9	2.3	3.2	2.9	3.0	3.4	2.5	2.8	1.1	-3.3
Average weekly spirits intake	0.7	0.9	3.4	-1.3	-0.4	-0.8	-0.8	-0.8	-1.2	-1.1	-0.7	-0.8	-0.2	-1.8	-0.8	-0.5	-0.8	0.7
Sensitivity / hurt feelings	1.2	2.1	3.6	1.6	1.5	1.5	1.2	1.2	1.4	1.4	1.8	1.5	1.9	1.6	1.6	1.2	0.7	-1.5
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.2	0.4	1.1	0.7	0.7	0.8	0.8	0.9	0.8	0.8	0.9	0.3	1.0	0.7	0.5	-0.5
Hearing difficulty/problems: Yes	0.7	1.1	3.1	-1.3	-1.1	-1.0	-0.9	-1.3	-0.4	-0.5	-1.3	-0.6	-1.8	-0.5	-0.6	-1.2	-1.1	1.0
Relative age of first facial hair	0.4	0.8	1.5	-0.7	-1.1	-1.2	-1.1	-0.7	-0.6	-0.8	-0.2	-1.0	-1.2	-0.2	-0.9	-1.2	-0.3	0.7
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.3	-1.0	-0.9	-1.0	-0.8	-0.5	-1.0	-1.1	-0.8	-0.9	-0.5	-1.3	-1.0	-1.0	-1.5	0.9
Ever used hormone-replacement therapy (HRT)	5.7	7.2	9.1	2.3	2.7	3.0	2.7	2.5	2.8	2.9	2.2	3.0	2.6	2.7	2.9	2.6	2.3	-2.9
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	-0.2	0.1	0.3	0.1	0.3	0.5	0.4	-0.4	0.5	0.3	0.3	0.2	-0.2	-0.4	-0.4
Systolic blood pressure, automated reading	4.6	13.4	27.7	4.1	3.2	3.6	2.8	3.1	3.3	3.0	3.9	3.9	3.7	5.3	3.6	2.9	2.7	-4.8
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.8	-0.9	-0.2	-0.2	-0.2	0.2	-0.0	-0.2	0.1	-0.0	0.2	-0.0	0.0	-0.5	-0.6	-0.2
Angina	4.6	6.0	8.9	1.8	2.3	2.4	2.6	2.4	3.0	2.5	1.9	2.9	2.6	2.6	2.5	2.3	2.0	-2.7
Medication for hormone replacement therapy	0.1	0.1	0.6	0.2	0.1	-0.0	0.0	-0.1	0.6	0.8	0.4	0.2	-0.1	0.6	0.6	0.0	0.4	0.1
Vitamin and mineral supplements	2.8	3.8	6.6	2.1	1.9	1.8	1.9	1.2	1.9	2.3	1.4	1.9	2.2	1.9	2.6	1.8	2.3	-1.5
Supplements: Zinc	0.2	0.3	1.0	-0.5	-0.3	-0.3	-0.3	0.3	-0.5	-1.0	0.2	-0.4	-0.5	-0.6	-0.6	-0.3	-0.9	0.1
Medication: Co-codamol	1.2	1.4	3.0	0.7	1.1	1.3	1.4	1.7	1.3	0.8	1.2	1.3	1.1	1.1	1.2	0.9	0.5	-1.4
Medication: Metformin	3.1	4.4	8.7	1.5	2.1	2.1	2.3	2.8	1.6	1.5	1.9	2.2	2.9	1.7	2.0	2.1	0.9	-2.6
Diabetes (father)	0.7	0.9	2.0	0.4	0.7	0.9	1.0	1.4	0.7	1.0	0.3	1.1	1.0	0.8	0.9	1.0	1.0	-1.2
Diabetes (mother)	0.1	0.2	0.7	-0.4	0.2	-0.1	0.1	0.8	0.1	-0.0	0.9	-0.3	-0.1	-0.6	-0.1	0.1	-0.0	0.4
Severe depression (siblings)	1.7	1.9	2.9	-1.4	-1.1	-1.5	-1.5	-1.7	-1.4	-1.3	-1.0	-1.6	-1.2	-1.2	-1.3	-1.4	-1.4	1.7
Pack years adult smoking proportion	3.4	5.1	7.5	2.1	2.4	2.1	2.0	2.2	2.3	2.2	2.4	1.9	2.7	1.9	2.5	2.2	2.7	-2.2
Impedance of leg (right)	0.7	3.6	8.6	1.3	1.9	2.3	2.1	2.9	1.9	2.0	1.5	1.8	1.7	1.4	1.4	1.9	1.8	-1.8
Leg fat-free mass (left)	0.7	3.7	7.5	-1.8	-1.7	-2.7	-2.0	-1.9	-1.9	-2.5	-0.5	-2.2	-1.7	-1.8	-1.8	-2.0	-1.3	1.9
Trunk fat percentage	5.0	20.1	25.3	4.2	4.9	4.3	4.6	4.5	4.2	3.9	5.0	4.6	4.8	4.6	4.4	4.5	4.1	-4.5
Hand grip strength (right)	3.4	9.1	12.2	-3.5	-3.0	-3.4	-3.2	-2.7	-2.8	-3.3	-2.2	-3.2	-3.1	-3.2	-2.9	-3.2	-2.7	2.7
Townsend deprivation index at recruitment	3.7	5.2	8.4	2.2	2.6	2.3	2.3	2.3	2.2	1.9	2.9	2.2	2.9	1.9	2.4	2.2	1.4	-2.2
Current tobacco smoking	0.2	0.4	1.4	-0.8	-0.3	-0.6	-0.7	-0.4	-0.6	-0.6	0.4	-0.6	0.5	-1.2	-0.2	-0.4	-0.8	0.2
Average weekly fortified wine intake	0.2	0.2	0.5	0.5	0.6	0.4	0.6	0.5	0.5	0.1	0.3	0.3	0.6	-0.1	0.7	0.5	-0.1	-0.2
Maternal smoking around birth	0.4	0.6	1.7	-0.8	-0.6	-0.8	-0.6	-0.8	-0.6	-0.4	-1.3	-0.7	-0.3	-1.2	-0.1	-0.5	-1.1	1.2
Fed-up feelings	2.0	3.6	5.4	1.7	1.8	1.8	2.1	2.0	2.3	2.1	1.5	1.9	1.8	2.1	2.3	1.9	1.3	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.4	-0.0	0.2	0.1	0.3	0.4	0.6	0.6	-0.6	0.3	0.1	0.0	0.4	0.1	0.4	0.1
Relative age voice broke	0.3	0.4	0.8	-0.8	-0.6	-0.8	-0.8	-0.4	-0.7	-0.7	0.2	-0.6	-0.6	-0.6	-0.9	-0.9	-0.5	0.2
Taking other prescription medications	4.7	7.3	10.8	2.6	2.7	2.7	2.7	2.7	2.5	2.1	3.2	2.7	3.3	3.1	2.7	2.4	1.2	-3.2
Age when periods started (menarche)	5.7	13.6	21.6	-3.7	-3.3	-4.1	-3.7	-2.3	-3.9	-4.6	-2.4	-4.3	-3.0	-4.6	-3.8	-3.7	-3.6	3.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.4	-0.8	-0.6	-0.7	-0.4	0.3	-0.5	-0.9	-0.2	-0.7	-0.8	-1.2	-0.6	-0.6	-0.8	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.7	1.3	1.0	0.8	0.9	0.5	0.9	0.8	1.1	0.9	0.8	1.1	1.0	1.1	1.2	-0.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	1.1	0.5	0.4	0.5	0.6	1.1	0.5	0.2	0.2	0.3	0.1	0.6	0.4	0.3	-0.0	-0.3
Qualifications: CSEs or equivalent	2.0	2.6	3.6	-1.7	-1.7	-1.5	-1.8	-1.5	-1.4	-0.9	-1.8	-1.6	-1.6	-1.8	-1.5	-1.6	-1.9	1.8
Serious illness, injury or assault to yourself	0.1	0.2	0.7	0.1	0.1	-0.1	0.3	0.7	0.0	0.1	-0.7	0.0	-0.0	-0.5	0.1	0.5	-0.9	0.2
High blood pressure	4.5	12.5	19.6	3.6	3.1	3.5	3.2	3.6	3.8	3.0	3.8	3.6	4.0	4.4	3.8	2.6	1.5	-4.4
Hayfever, allergic rhinitis or eczema	8.7	18.9	28.2	4.1	4.3	4.3	3.9	3.6	5.0	4.8	5.2	4.5	3.8	5.3	4.3	3.4	3.7	-4.6
Multivitamins +/- minerals	0.7	0.9	2.3	-1.3	-0.6	-0.8	-0.7	-0.3	-1.0	-1.1	-0.5	-0.9	-1.0	-1.5	-1.4	-0.5	-0.9	0.9
Stomach or abdominal pain in last month	0.3	0.4	1.0	0.5	0.5	0.7	0.8	1.0	0.9	1.0	-0.2	0.7	0.4	0.6	0.7	0.6	0.5	-0.3
Supplements: Glucosamine	1.6	2.1	2.7	-1.2	-1.3	-1.5	-1.5	-1.2	-1.6	-1.5	-0.9	-1.5	-1.6	-1.6	-1.6	-1.4	-1.2	1.6
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.7	0.7	0.7	0.7	1.0	1.1	0.6	0.4	0.5	0.7	0.4	1.3	0.4	0.7	0.3	-1.1
Medication: Atenolol	3.2	4.0	7.1	1.9	2.2	2.0	2.1	1.7	1.9	1.4	2.4	2.0	2.7	1.9	1.9	1.9	1.0	-2.3
Medication: Levothyroxine sodium	2.9	4.9	7.8	1.8	2.1	2.0	2.5	2.8	2.4	1.9	2.0	2.3	2.8	2.1	2.5	2.1	1.4	-2.1
Sitting height	3.1	22.1	29.2	-5.0	-4.5	-5.4	-4.7	-4.4	-4.7	-5.0	-3.7	-5.1	-4.9	-5.0	-4.3	-4.8	-3.7	5.1
Chronic bronchitis/emphysema (father)	0.4	0.5	1.6	-0.3	-0.5	-0.5	-0.4	-0.8	-0.6	-0.9	-1.2	-0.7	-0.2	-0.7	-0.7	-0.5	-1.3	0.5
High blood pressure (mother)	0.2	0.3	2.1	0.4	0.4	0.2	0.5	1.5	0.7	0.2	0.9	0.2	0.6	0.5	0.4	-0.0	-0.1	-0.5
Body mass index (BMI)	3.2	13.7	18.0	3.6	4.0	3.4	3.7	3.2	3.5	3.1	4.1	3.8	4.0	4.2	3.7	3.7	3.5	-3.6
Impedance of leg (left)	0.3	1.3	4.0	0.4	1.1	1.6	1.3	2.0	1.2	1.5	0.7	1.2	0.9	0.5	1.0	1.1	1.1	-0.8
Leg predicted mass (left)	0.7	3.8	7.7	-1.8	-1.8	-2.8	-2.1	-1.9	-2.0	-2.5	-0.6	-2.3	-1.7	-1.8	-1.8	-2.1	-1.3	1.9
Trunk fat mass	2.1	9.2	15.3	2.7	3.4	2.6	3.1	3.1	2.8	2.3	3.9	3.0	3.3	3.1	3.0	2.9	2.9	-3.0
Waist circumference	0.4	1.5	5.8	0.8	1.5	0.7	1.1	1.3	0.6	0.1	2.4	1.0	1.8	1.2	0.9	1.0	0.9	-1.3
Number of incorrect matches in round	1.0	1.7	2.6	-1.3	-1.5	-1.0	-1.3	-1.2	-1.3	-1.2	-1.4	-1.3	-1.3	-1.1	-1.6	-1.0	-1.5	1.4
Past tobacco smoking	1.2	2.2	4.5	1.5	1.3	1.6	1.4	1.2	1.7	2.1	0.5	1.4	0.6	2.0	1.4	1.4	2.0	-1.1
Alcohol usually taken with meals	0.1	0.2	1.1	-0.9	-0.0	0.0	-0.2	-0.6	-0.1	-0.3	-0.5	-0.2	-1.0	0.2	-0.3	-0.3	0.4	0.0
Nervous feelings	0.2	0.4	1.8	-0.6	-0.5	-0.3	-0.9	-1.4	-0.8	-0.0	-0.3	-0.4	-0.1	-0.7	-0.3	-0.5	-0.5	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.5	0.2	0.6	0.4	0.4	0.5	0.6	0.7	0.4	0.6	0.7	0.3	0.7	0.3	0.2	-0.4
Hearing difficulty/problems with background noise	0.1	0.2	1.0	0.1	-0.1	0.2	-0.2	-1.0	0.4	0.5	-0.4	0.3	-0.6	0.8	0.2	-0.2	0.0	-0.1
Hair/balding pattern: Pattern 2	2.9	3.7	5.0	-2.2	-2.0	-2.0	-2.1	-1.8	-2.0	-2.0	-1.2	-2.1	-1.9	-1.9	-2.0	-2.1	-1.6	1.7
Had menopause	9.3	11.6	18.4	3.4	3.4	3.8	3.4	3.0	3.4	3.1	2.9	3.6	3.3	4.3	3.3	3.4	2.8	-3.7
Had other major operations	4.6	5.6	7.4	2.3	2.6	2.4	2.7	2.1	2.6	2.3	2.0	2.3	2.1	2.7	2.6	2.4	2.3	-1.9
Forced vital capacity (FVC)	0.4	1.6	4.0	-1.1	-1.5	-1.7	-1.4	-1.1	-0.4	-1.0	-0.4	-1.6	-2.0	-0.4	-1.1	-1.8	-1.0	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.7	1.3	0.9	0.6	0.7	0.1	0.7	0.9	0.7	0.8	0.5	0.9	0.9	1.0	1.1	-0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.8	-0.3	0.2	-0.1	0.3	0.2	0.1	-0.1	-0.4	-0.1	0.0	-0.9	0.3	0.2	-0.2	0.7
Qualifications: None of the above	1.3	2.8	5.7	2.2	1.8	1.7	1.7	1.4	1.1	1.1	1.6	1.6	2.4	1.4	1.4	2.1	1.2	-1.9
Financial difficulties in last 2 years	1.1	1.5	2.9	1.2	1.4	0.9	1.2	1.7	1.1	0.6	1.6	0.9	1.7	1.0	1.3	1.2	0.7	-1.2
Mouth/teeth dental problems	0.2	0.2	1.0	1.0	0.2	0.3	0.3	0.7	0.4	0.2	0.3	0.2	-0.1	0.9	0.3	0.3	0.7	-0.2
Heart attack	0.1	0.2	0.5	-0.3	0.3	0.3	0.5	0.6	0.5	-0.0	0.3	0.5	0.7	0.4	0.3	0.2	-0.2	-0.6
Allergy	9.3	21.4	29.7	-4.2	-4.6	-4.8	-4.3	-3.9	-5.2	-5.1	-5.4	-4.8	-4.2	-5.4	-4.6	-3.8	-3.6	4.9
Pain all over the body in last month	1.3	1.4	2.5	1.1	1.1	1.2	1.1	1.1	1.6	1.2	0.6	1.2	1.2	1.6	1.5	0.7	0.8	-1.4
Diabetes (self-reported)	2.3	3.5	7.0	1.5	2.0	1.9	2.1	2.6	1.4	1.4	1.9	1.9	2.6	1.3	1.5	2.1	0.8	-1.9
Hayfever/allergic rhinitis (self-reported)	6.3	8.3	10.9	3.0	3.1	3.0	2.8	2.6	2.9	2.8	3.3	2.8	2.8	3.3	2.9	2.6	2.3	-3.0
Medication: Ramipril	2.7	3.5	4.9	1.7	1.7	1.9	1.7	2.0	2.1	1.9	1.8	2.0	2.1	2.2	2.1	1.4	0.7	-2.2
Medication: Simvastatin	4.1	6.0	8.8	2.1	2.5	2.9	2.5	2.5	2.5	2.2	2.1	2.9	2.8	2.3	2.5	2.4	0.8	-3.0
Fluid intelligence score	0.0	0.1	0.2	-0.5	-0.0	0.1	-0.1	-0.3	0.0	0.1	0.5	0.1	-0.4	-0.1	0.2	-0.4	0.2	-0.4
Illnesses of siblings	4.8	6.7	9.0	-2.9	-2.6	-2.4	-2.4	-2.3	-2.8	-2.6	-3.0	-2.6	-2.6	-2.9	-2.7	-2.3	-2.0	2.7
Neuroticism score	0.3	0.6	1.4	0.4	0.8	0.7	0.7	0.5	0.7	0.8	0.9	0.7	1.2	0.9	1.0	0.5	0.5	-0.6
Weight	0.1	0.3	2.4	0.0	0.6	-0.3	0.3	0.2	0.3	-0.4	1.6	0.2	0.5	0.6	0.4	0.2	0.6	-0.3
Impedance of arm (right)	0.4	1.9	3.5	0.9	1.3	1.7	1.4	1.8	1.5	1.9	0.9	1.5	1.1	1.0	1.4	1.2	1.1	-1.4
Arm fat percentage (right)	6.2	24.6	29.2	4.7	5.3	4.9	5.0	4.7	4.8	4.5	5.2	5.2	5.2	5.4	5.0	5.0	4.5	-5.0
Trunk fat-free mass	2.7	15.3	22.4	-4.0	-3.7	-4.7	-4.0	-3.6	-3.8	-4.6	-2.4	-4.4	-3.9	-4.0	-3.8	-4.0	-3.1	4.0
Hip circumference	0.2	0.9	3.9	0.7	1.1	0.3	0.7	0.4	0.8	0.3	2.0	0.9	0.8	1.5	1.0	0.6	0.9	-0.9
Time employed in main current job	4.5	5.2	7.6	-2.2	-2.3	-2.4	-2.4	-1.9	-2.7	-2.8	-1.5	-2.3	-1.8	-2.7	-2.3	-2.5	-2.2	1.7
Alcohol intake versus 10 years previously	0.2	0.2	1.4	-0.5	-0.5	0.0	-0.2	-0.2	0.1	-0.3	-1.1	-0.2	-0.2	-0.2	-0.3	-0.4	-1.2	0.1
Father’s age at death	0.6	0.8	2.2	-0.7	-0.4	-0.8	-0.7	-1.5	-1.3	-1.3	-0.7	-0.9	-0.6	-1.4	-0.7	-0.4	-0.2	0.8
Worrier / anxious feelings	1.4	2.6	3.4	1.5	1.5	1.6	1.5	1.6	1.8	1.8	1.6	1.7	1.8	1.7	1.6	1.3	1.5	-1.5
Frequency of tiredness / lethargy in last 2 weeks	3.1	5.1	7.7	2.2	2.5	2.3	2.6	2.2	2.1	2.3	1.5	2.4	2.8	2.0	2.6	2.6	1.5	-1.8
Falls in the last year	0.9	1.2	2.1	0.7	1.2	1.3	1.3	1.4	0.9	0.7	1.0	1.2	1.4	0.9	1.0	1.2	0.8	-1.2
Hair/balding pattern: Pattern 3	0.1	0.2	0.8	0.8	0.2	0.4	0.3	0.3	0.1	-0.0	0.5	0.3	0.9	0.8	0.0	0.2	-0.1	-0.6
Number of live births	3.5	5.0	7.0	2.0	2.3	2.5	2.1	2.2	2.0	1.8	2.3	2.2	2.6	2.4	2.1	2.3	2.0	-2.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.8	-0.3	-0.4	-0.7	-0.4	0.5	0.4	-0.3	0.8	-0.5	-0.9	0.5	-0.1	-0.7	0.0	0.1
Pulse rate	0.2	0.3	1.2	-0.7	-0.5	-0.4	-0.3	0.1	-0.6	-0.7	-0.3	-0.2	-0.1	-0.7	-0.6	-0.6	-1.1	-0.2
Happiness	0.6	0.7	1.9	-1.3	-0.6	-0.7	-0.6	-0.6	-1.0	-0.6	-1.0	-0.8	-0.8	-1.4	-0.9	-0.4	-0.5	1.2
Noisy workplace	0.4	0.4	1.0	-0.4	-0.7	-0.8	-0.7	-0.7	-0.2	-0.3	-0.6	-0.7	-0.7	-0.3	-0.2	-0.9	-1.0	0.8
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.4	0.4	1.2	1.2	1.2	1.0	1.4	1.2	1.1	1.5	0.2	1.2	1.5	0.6	1.2	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.6	-1.1	-0.7	-0.7	-0.7	-0.8	-0.5	-0.0	-1.3	-0.5	-0.7	-0.8	-0.3	-0.9	-0.8	0.9
Mouth/teeth dental problems: Dentures	0.5	0.8	3.0	0.5	1.0	0.5	0.7	0.9	0.6	0.2	1.7	0.6	1.7	0.1	1.0	0.7	-0.1	-1.0
Asthma	8.5	16.8	21.2	3.5	4.2	4.4	4.2	3.9	4.6	4.6	4.1	4.5	3.6	4.1	4.1	3.8	3.2	-4.3
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.1	-1.5	-0.7	-1.0	-1.0	-0.5	-1.1	-1.4	0.1	-1.1	-0.5	-1.1	-1.2	-1.0	-1.3	0.6
Medication: Cholesterol lowering	6.8	10.6	13.0	2.5	3.3	3.6	3.3	3.3	3.6	3.1	3.5	3.4	3.4	3.6	3.3	3.1	2.1	-3.5
Depression (self-reported)	0.0	0.1	0.3	0.0	0.0	-0.1	-0.2	-0.4	-0.1	0.1	-0.1	-0.2	0.1	0.0	-0.3	0.2	-0.0	0.6
Medication: Lansoprazole	1.3	1.5	2.3	0.6	1.2	1.4	1.4	1.4	1.5	1.4	0.4	1.4	1.1	1.3	1.4	1.1	0.8	-1.2
Prospective memory result	0.8	1.0	3.0	1.3	1.0	0.8	1.0	1.1	0.4	0.8	0.6	0.8	1.0	1.0	0.8	1.3	1.7	-0.6
Lung cancer (father)	1.8	2.1	3.5	-1.4	-1.4	-1.5	-1.4	-1.0	-1.6	-1.5	-1.3	-1.7	-1.1	-1.7	-1.8	-1.4	-0.8	1.9
Illnesses of mother	0.3	0.4	1.3	-0.4	-0.3	-0.2	-0.6	-1.0	-0.8	-0.6	-0.7	-0.6	-0.2	-1.2	-0.7	-0.1	-0.3	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.1	0.0	-0.0	-0.2	0.0	0.8	0.7	0.2	1.1	-0.1	-0.5	0.9	0.3	-0.4	0.2	-0.2
Pulse wave Arterial Stiffness index	0.8	1.0	1.9	1.1	1.0	0.9	1.0	0.9	0.7	0.6	0.7	1.1	1.4	1.3	0.9	0.7	0.7	-1.4
Impedance of arm (left)	0.4	1.7	3.3	1.2	1.2	1.6	1.4	1.8	1.4	1.8	0.7	1.4	0.8	1.1	1.2	1.2	0.9	-1.4
Arm fat mass (right)	2.8	11.6	16.1	3.1	3.7	3.1	3.4	3.3	3.3	2.8	4.0	3.5	3.6	3.8	3.4	3.3	3.2	-3.4
Trunk predicted mass	2.5	14.5	21.3	-4.0	-3.6	-4.6	-3.9	-3.5	-3.7	-4.5	-2.2	-4.3	-3.7	-3.9	-3.7	-3.9	-2.9	3.9
Standing height	4.8	47.8	60.5	-7.4	-6.9	-7.8	-7.1	-6.0	-6.7	-7.3	-5.1	-7.5	-7.1	-7.4	-6.8	-7.3	-6.0	6.8
Length of working week for main job	0.9	1.0	1.8	-1.1	-1.1	-1.3	-1.1	-0.7	-0.9	-1.1	-0.4	-1.0	-0.9	-0.9	-1.3	-1.2	-0.6	0.8
Exposure to tobacco smoke at home	3.4	3.9	5.0	1.8	2.1	1.9	2.0	2.0	2.0	1.7	2.2	1.8	2.2	2.2	2.0	1.8	1.5	-2.0
Breastfed as a baby	0.6	0.8	1.8	-1.4	-0.7	-0.6	-0.9	-1.3	-0.7	-0.7	-0.6	-0.7	-0.4	-1.2	-0.7	-0.8	-1.0	0.8
Tense / ‘highly strung’	0.1	0.1	0.4	0.2	0.2	0.3	-0.1	-0.2	0.1	0.3	0.5	0.1	0.6	0.6	0.4	0.1	0.5	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.7	0.9	1.1	1.2	1.1	1.1	1.1	1.2	0.7	1.2	1.0	1.0	1.3	1.1	0.5	-1.1
Hair/balding pattern: Pattern 4	0.1	0.3	1.1	0.1	-0.3	-0.5	-0.5	-1.0	-0.6	-0.5	-0.5	-0.4	-0.7	-0.5	-0.6	-0.0	0.1	0.8
Birth weight of first child	4.7	8.6	13.2	-3.2	-2.9	-3.2	-2.8	-2.0	-3.0	-3.2	-2.5	-3.0	-2.7	-3.6	-3.2	-2.8	-2.3	3.0
Peak expiratory flow (PEF)	0.6	1.3	3.9	-1.3	-1.3	-1.4	-1.2	-0.5	-0.8	-1.0	-0.5	-1.2	-2.0	-0.8	-0.9	-1.5	-0.7	1.0
Pulse wave reflection index	4.6	5.6	7.1	2.6	2.3	2.1	2.4	2.7	2.5	2.4	1.8	2.3	2.2	2.6	2.4	2.1	2.5	-2.3
Ever highly irritable/argumentative for 2 days	2.3	2.7	3.9	1.3	1.8	1.7	1.8	1.8	2.0	1.8	1.7	1.6	1.4	1.6	1.7	1.7	1.5	-1.3
Loud music exposure frequency	0.2	0.2	1.6	-0.1	-0.2	0.0	0.3	0.2	0.4	0.4	-1.2	0.1	-0.5	-0.2	0.5	0.1	0.2	-0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.2	0.6	0.3	0.8	0.7	0.9	0.9	0.8	0.7	0.9	0.4	1.1	0.4	0.3	0.8	-1.0
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.4	-0.2	0.1	0.6	0.1	-0.6	0.2	0.7	-0.6	0.6	0.1	0.2	0.1	0.3	0.3	-0.2
Blood clot in the leg (DVT)	0.6	0.8	1.4	0.7	1.1	1.2	0.8	0.6	0.9	0.8	1.1	0.8	1.2	1.2	0.8	0.7	0.3	-0.6
Medication: Paracetamol	0.7	1.2	3.0	1.0	1.2	1.1	0.9	1.5	0.8	0.6	1.7	1.0	1.2	0.5	1.1	1.2	0.2	-1.3
Headache pain in last month	3.5	5.9	9.2	1.8	2.5	2.3	2.6	3.0	2.5	2.4	2.0	2.6	2.2	2.5	2.4	2.2	3.0	-2.3
Medication for cholesterol, blood pressure or diabetes	3.8	6.3	9.9	-2.2	-2.3	-2.6	-2.4	-2.7	-2.9	-2.3	-3.2	-2.4	-2.4	-3.1	-2.5	-2.0	-1.0	2.9
Glaucoma (self-reported)	1.2	1.4	3.3	-0.9	-1.6	-1.1	-1.3	-1.4	-0.7	-0.7	-1.2	-1.0	-1.8	-0.1	-1.4	-1.3	-1.3	0.9
Gout (self-reported)	0.3	0.4	1.3	-0.3	-0.6	-0.8	-0.5	-0.6	-0.8	-0.7	-0.7	-0.6	-0.2	-1.1	-0.5	-0.5	-0.8	0.7
Hypothyroidism/myxoedema (self-reported)	1.9	3.7	6.0	1.7	1.8	1.8	1.9	2.2	1.8	1.7	2.0	1.9	2.5	1.9	1.8	2.0	1.8	-1.8
Medication: Amlodipine	1.7	2.5	4.4	1.4	1.3	1.7	1.4	1.8	1.8	1.3	1.7	1.7	1.7	1.9	1.5	1.0	0.5	-2.1
Medication: Ventolin 100micrograms inhaler	4.7	6.0	9.9	2.5	2.5	2.6	2.1	1.9	2.4	2.2	2.7	2.4	2.5	3.1	2.4	2.1	2.1	-2.8
Birth weight	1.3	2.8	5.3	-1.8	-1.5	-2.1	-1.4	-0.9	-1.6	-1.9	-1.2	-1.9	-1.7	-1.7	-1.5	-1.5	-1.6	2.3
Chronic bronchitis/emphysema (mother)	0.7	0.9	1.9	0.8	0.9	1.0	0.9	1.3	1.1	0.8	0.8	0.8	0.9	1.4	0.6	0.8	0.9	-0.7
High blood pressure (siblings)	5.5	7.9	10.6	3.1	2.9	2.7	2.5	2.4	2.9	2.8	3.3	2.6	3.1	3.1	2.7	2.6	2.4	-2.9
Forced vital capacity (FVC), Best measure	0.1	0.5	1.9	-0.4	-0.8	-0.9	-0.7	-0.3	0.3	-0.2	0.3	-0.8	-1.4	0.5	-0.3	-1.2	-0.5	0.5
Body fat percentage	6.6	25.9	30.5	4.8	5.5	5.0	5.2	5.0	4.8	4.5	5.5	5.3	5.3	5.3	5.0	5.2	4.8	-5.1
Leg fat percentage (right)	8.1	29.5	34.2	5.3	5.8	5.4	5.5	5.3	5.1	4.8	5.7	5.6	5.5	5.8	5.2	5.6	5.2	-5.4
Arm fat-free mass (right)	1.7	8.7	13.8	-3.0	-2.7	-3.7	-3.0	-2.8	-3.0	-3.6	-1.4	-3.4	-2.8	-3.0	-2.9	-3.0	-2.2	3.1
Exposure to tobacco smoke outside home	1.1	1.5	2.1	-1.5	-1.3	-1.2	-1.2	-1.3	-0.7	-1.0	-1.4	-1.1	-1.3	-1.1	-1.3	-1.4	-1.1	1.1
Comparative body size at age 10	4.4	12.1	15.5	3.9	3.7	3.4	3.3	2.8	3.5	3.4	3.6	3.3	3.8	3.9	3.7	3.4	3.4	-2.9
Number of full brothers	1.5	1.8	4.8	1.1	1.5	1.2	1.2	1.7	1.4	1.2	2.2	1.1	1.6	0.7	1.2	1.2	1.1	-1.3
Worry too long after embarrassment	0.1	0.1	0.6	0.6	0.2	0.2	0.1	0.2	0.3	0.2	0.5	0.3	0.4	0.8	0.3	-0.0	-0.3	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.6	-1.0	-0.6	-0.6	-0.9	-0.9	-0.9	-1.0	-0.3	-0.7	-0.9	-0.6	-0.9	-0.7	-1.3	0.4
Wheeze or whistling in the chest in last year	1.8	3.2	6.1	1.5	1.8	1.9	1.7	1.8	1.6	1.5	2.1	2.1	2.0	1.5	1.8	1.4	1.1	-2.5
Number of children fathered	0.1	0.1	0.8	-0.4	-0.2	-0.3	-0.1	-0.1	0.1	-0.0	-0.2	-0.1	-0.4	-0.9	-0.1	-0.3	0.3	0.2
Reason for reducing amount of alcohol drunk: Health precaution	2.5	2.9	4.2	-1.6	-1.8	-1.7	-1.9	-2.0	-1.8	-1.8	-1.7	-1.7	-2.0	-1.0	-1.6	-2.1	-1.4	1.4
Age at first live birth	1.6	2.8	5.1	-1.5	-1.9	-1.8	-1.4	-1.3	-1.5	-1.6	-2.0	-1.6	-2.3	-1.1	-1.7	-1.6	-1.8	1.5
Pulse wave peak to peak time	1.7	2.0	3.3	-1.6	-1.4	-1.4	-1.5	-1.3	-1.1	-1.0	-1.0	-1.5	-1.8	-1.7	-1.3	-1.2	-1.1	1.8
Health satisfaction	1.8	2.4	3.9	1.2	1.5	1.7	1.8	2.0	1.8	1.9	1.0	1.6	1.3	1.7	1.5	1.5	1.2	-1.4
Shortness of breath walking on level ground	2.2	2.6	4.6	1.5	1.4	1.6	1.5	1.7	2.0	1.9	1.2	1.7	1.3	2.1	1.6	1.3	1.5	-1.4
Qualifications: College or University degree	0.1	0.2	2.0	-0.8	-0.3	-0.3	0.0	-0.0	0.1	0.1	-0.5	0.1	-1.4	-0.0	-0.2	-0.5	0.5	0.0
Eye problems/disorders: None of the above	0.1	0.1	0.4	0.5	0.7	0.3	0.3	0.3	0.3	0.2	0.5	0.2	0.4	-0.1	0.3	0.3	0.1	0.0
Mouth/teeth dental problems: Loose teeth	2.6	3.1	5.5	-2.0	-1.5	-1.8	-1.7	-2.0	-1.9	-1.6	-1.7	-1.7	-1.3	-2.3	-1.6	-1.6	-1.3	2.1
Emphysema/chronic bronchitis	0.1	0.1	0.3	0.6	0.3	0.3	0.2	0.0	-0.1	0.0	0.3	0.1	0.3	0.2	0.1	0.5	0.4	-0.0
Medication for pain relief, constipation, heartburn	3.8	6.5	10.7	-2.0	-2.7	-2.6	-2.7	-3.3	-2.4	-1.9	-3.1	-2.6	-2.7	-2.2	-2.3	-2.8	-1.5	2.9
Neck or shoulder pain in last month	1.9	2.8	4.7	1.4	1.8	1.8	1.8	1.8	1.8	1.8	1.2	1.6	1.4	1.6	1.8	1.4	2.2	-1.4
Medication: Blood pressure	2.0	3.5	5.5	1.6	1.7	1.9	1.9	2.1	2.2	1.8	2.4	1.9	1.9	1.8	2.0	1.5	0.4	-2.2
Angina (self-reported)	5.3	7.0	9.9	2.0	2.6	2.6	2.8	2.5	3.1	2.7	2.1	3.0	2.8	2.8	2.6	2.6	2.2	-2.9
Migraine (self-reported)	0.4	0.5	1.9	-1.4	-0.6	-0.6	-0.5	-0.2	-0.6	-0.5	-0.7	-0.6	-1.2	-0.6	-0.7	-0.7	-0.2	0.9
Medication: Ibuprofen	1.1	1.4	2.5	-1.6	-0.9	-1.2	-1.3	-0.7	-1.2	-1.5	-0.2	-1.4	-0.7	-1.1	-1.5	-1.2	-1.3	0.8
Medication: Allopurinol	0.1	0.1	0.3	0.6	-0.0	-0.1	0.1	-0.1	-0.0	0.4	-0.3	-0.0	-0.0	-0.4	0.2	0.2	-0.1	0.6
Medication: Omeprazole	2.1	2.5	3.6	1.4	1.5	1.7	1.7	1.9	1.6	1.3	1.2	1.5	1.5	1.9	1.6	1.8	1.2	-1.6
Medication: Seretide 50 evohaler	2.0	2.3	4.0	1.0	1.4	1.7	1.5	1.4	1.5	1.7	0.9	1.9	1.3	2.0	1.4	1.3	1.2	-1.7
Mean time to correctly identify matches	0.4	0.7	1.8	0.9	1.0	1.1	1.2	1.2	0.6	0.5	0.1	0.8	1.1	0.2	0.7	1.4	0.4	-0.3
Heart disease (mother)	1.5	1.9	3.0	0.8	1.1	1.2	1.6	1.6	1.6	1.3	1.3	1.5	1.1	1.7	1.3	1.2	1.2	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	0.2	0.6	0.4	0.5	0.7	0.2	0.1	0.7	0.3	0.7	0.3	0.4	0.4	-0.0	-0.2
Whole body fat mass	2.7	11.2	17.7	3.1	3.7	2.9	3.4	3.3	3.1	2.6	4.2	3.3	3.6	3.6	3.2	3.3	3.3	-3.3
Leg fat mass (right)	3.4	13.2	19.3	3.6	3.9	3.3	3.7	3.6	3.4	2.8	4.4	3.6	3.8	4.1	3.4	3.7	3.5	-3.6
Arm predicted mass (right)	1.9	9.9	15.4	-3.3	-2.9	-3.9	-3.1	-2.9	-3.2	-3.8	-1.8	-3.6	-3.0	-3.2	-3.1	-3.2	-2.3	3.3
Pulse rate, automated reading	0.3	1.0	2.0	-1.1	-1.0	-1.0	-0.7	-0.2	-1.2	-1.4	-1.0	-0.9	-0.9	-1.2	-1.4	-0.7	-1.1	0.9
Alcohol intake frequency.	4.6	10.6	13.0	2.9	3.2	3.3	3.4	3.6	3.5	3.1	3.0	3.2	3.6	3.3	3.2	3.4	2.6	-3.3
Comparative height size at age 10	1.0	5.6	8.0	-2.3	-2.3	-2.8	-2.4	-1.6	-2.6	-2.7	-1.4	-2.6	-2.4	-2.8	-2.2	-2.5	-2.1	2.3
Number of full sisters	0.6	0.8	2.3	0.6	0.9	0.9	0.7	1.2	0.7	0.7	1.5	0.6	1.4	0.1	0.7	1.0	0.7	-0.6
Suffer from ‘nerves’	0.1	0.1	0.4	0.1	0.1	0.4	-0.2	-0.6	-0.2	0.4	-0.2	0.1	0.4	0.3	0.2	0.3	0.2	0.2
Overall health rating	2.6	5.6	9.0	2.2	2.5	2.5	2.5	2.5	2.4	2.2	2.5	2.3	3.0	2.3	2.4	2.4	1.2	-2.2
Chest pain or discomfort	1.2	1.7	3.6	0.9	1.1	1.4	1.2	1.3	1.6	1.3	0.8	1.5	1.0	1.9	1.3	1.0	1.2	-1.6
Had major operations	1.7	1.9	3.6	0.9	1.6	1.4	1.5	1.1	1.6	1.7	1.2	1.5	1.5	1.2	1.9	1.4	1.0	-1.0
Age at last live birth	1.7	2.5	3.4	-1.5	-1.6	-1.6	-1.3	-1.4	-1.7	-1.8	-1.8	-1.6	-1.6	-1.5	-1.6	-1.5	-1.8	1.4
Family relationship satisfaction	0.5	0.7	1.2	0.1	0.9	1.0	1.1	1.0	0.9	1.1	0.0	1.0	0.6	0.4	0.7	0.9	0.9	-0.5
Leg pain on walking	2.9	3.6	5.7	1.5	1.9	1.6	1.9	2.4	2.1	2.0	2.0	1.6	2.1	1.9	1.9	1.8	2.2	-1.3
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.8	6.2	-2.0	-1.5	-1.8	-1.7	-1.1	-1.6	-1.5	-0.6	-1.6	-1.2	-2.5	-1.3	-1.7	-2.2	1.9
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.4	0.0	-0.1	0.0	-0.0	-0.1	0.2	-0.1	0.6	0.0	-0.0	0.5	0.0	-0.2	-0.1	-0.4
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	0.3	-0.2	0.0	-0.1	-0.4	-0.2	-0.2	-0.2	-0.1	-0.4	0.4	-0.5	-0.1	0.4	-0.1
Medication: Aspirin	4.1	5.4	8.1	1.7	2.3	2.5	2.7	2.8	2.7	2.3	1.8	2.6	2.1	2.2	2.2	2.5	1.6	-2.4
Supplements: Vitamin C	0.9	1.1	2.3	-1.3	-1.1	-0.9	-1.1	-0.7	-0.7	-1.1	-0.3	-0.9	-1.0	-0.6	-1.4	-1.4	-1.5	0.4
Knee pain experienced in last month	2.2	3.5	6.9	1.4	2.0	2.0	2.2	2.6	1.7	1.6	1.4	2.0	1.9	1.2	1.6	2.2	1.7	-1.8
Hypertension (Self-reported)	4.7	13.1	20.8	3.7	3.2	3.6	3.3	3.8	3.9	3.2	4.0	3.6	4.0	4.6	3.8	2.7	1.5	-4.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.6	-0.2	-0.4	-0.4	-0.3	-0.1	-0.3	-0.2	-0.7	-0.3	-0.3	-0.3	-0.2	-0.4	-0.8	0.2
Illnesses of father: Heart disease	5.9	8.2	11.4	2.6	2.8	3.2	3.0	2.3	3.1	3.1	2.1	3.2	2.6	3.4	3.1	2.9	2.3	-2.8
Illnesses of siblings: Diabetes	0.1	0.2	0.6	0.0	0.4	0.3	0.5	0.7	0.5	0.6	0.4	0.3	0.3	0.2	0.6	0.3	0.3	0.1
Smoking status: Previous	0.6	1.0	2.7	-0.9	-0.8	-1.0	-0.9	-0.6	-1.2	-1.6	-0.3	-0.9	-0.3	-1.2	-1.1	-0.9	-1.3	0.7
Forced expiratory volume in 1-second (FEV1), predicted	2.7	5.7	7.5	-2.7	-2.5	-2.7	-2.5	-2.0	-2.1	-2.2	-2.0	-2.7	-2.6	-2.3	-2.1	-2.4	-1.9	2.7
Whole body fat-free mass	2.0	11.5	18.0	-3.5	-3.2	-4.2	-3.5	-3.2	-3.4	-4.0	-1.9	-3.8	-3.2	-3.4	-3.2	-3.5	-2.6	3.5
Leg fat-free mass (right)	1.4	7.5	12.7	-2.6	-2.6	-3.6	-2.9	-2.9	-2.7	-3.2	-1.5	-3.0	-2.5	-2.7	-2.5	-2.9	-2.1	2.8
Arm fat percentage (left)	5.9	23.6	28.4	4.8	5.1	4.8	4.9	4.6	4.7	4.4	5.1	5.1	5.0	5.3	4.8	4.9	4.4	-4.9
Average weekly red wine intake	1.7	2.4	5.0	-2.1	-1.4	-1.6	-1.7	-2.0	-1.3	-1.1	-1.5	-1.2	-2.2	-1.6	-1.4	-1.7	-0.7	1.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.5	-0.0	0.3	0.1	-0.2	-0.7	-0.0	-0.3	0.6	-0.2	0.1	0.0	0.0	-0.1	0.0	0.2
Mood swings	0.0	0.1	0.5	-0.1	0.2	-0.0	0.1	-0.0	-0.0	-0.1	0.5	-0.0	0.5	0.1	0.3	-0.0	-0.7	0.2
Loneliness, isolation	0.0	0.1	0.5	-0.7	0.1	0.2	0.1	0.1	-0.1	-0.2	0.2	-0.2	0.3	0.0	-0.3	-0.2	-0.0	0.2
Long-standing illness, disability or infirmity	5.0	7.6	10.2	2.5	2.6	3.0	2.9	3.0	3.0	2.8	2.3	2.9	3.1	3.2	2.6	2.8	1.3	-2.9
Ever had bowel cancer screening	0.1	0.1	0.7	0.2	0.0	0.0	0.0	0.2	-0.6	-0.9	-0.3	-0.1	-0.1	-0.3	-0.7	0.2	-0.1	-0.2
Diabetes diagnosed by doctor	3.7	6.0	11.3	2.1	2.6	2.5	2.8	3.4	2.0	1.8	2.5	2.5	3.3	2.0	2.1	2.6	1.1	-2.6
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.3	3.3	1.8	1.5	1.5	1.3	1.4	1.5	1.5	1.5	1.5	1.5	1.7	1.7	1.3	1.0	-1.8
Friendships satisfaction	2.2	2.7	4.4	1.2	1.7	1.8	2.1	2.0	1.8	2.0	1.0	1.9	1.3	1.1	1.8	1.8	1.5	-1.2
Qualifications: nursing, teaching	0.4	0.7	2.0	-0.9	-0.8	-1.0	-0.6	-0.5	-0.5	-0.5	-1.2	-0.6	-1.4	-0.7	-0.5	-0.8	-0.7	0.7
Commuting to job workplace: Walk	0.2	0.2	1.3	-0.5	0.1	0.1	-0.1	-0.7	-0.6	0.1	-1.0	0.0	0.1	-1.2	0.0	0.2	0.1	0.5
Eye problems/disorders: Cataract	0.2	0.2	0.4	0.5	0.2	0.4	0.6	0.5	0.2	0.4	0.1	0.6	0.3	0.6	0.5	0.6	0.5	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.8	-1.2	-0.5	-0.6	-0.5	-0.6	-0.5	-0.2	-0.8	-0.5	-1.3	-1.1	-0.9	-0.6	-0.5	0.9
Medication for cholesterol	3.1	4.6	6.6	-1.9	-2.0	-2.1	-2.1	-2.1	-2.4	-2.0	-2.1	-2.4	-2.4	-2.5	-2.6	-1.7	-1.0	2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	10.6	12.5	15.5	3.9	3.7	3.7	3.4	3.2	3.3	3.2	3.9	3.4	3.9	3.5	3.4	3.8	2.8	-3.7
Back pain experienced in last month	0.6	0.8	1.6	0.4	1.1	0.9	0.9	1.0	0.7	0.1	1.2	0.8	1.0	0.7	0.9	0.7	0.8	-1.2
Mineral and other dietary supplements	1.0	1.4	3.0	1.4	1.1	1.2	1.3	0.7	1.1	1.4	0.8	1.0	1.7	1.2	1.4	1.2	0.9	-0.9
Breast cancer (self-reported)	0.1	0.2	0.6	0.8	-0.0	0.1	-0.3	-0.8	-0.3	0.1	-0.0	-0.1	0.5	0.7	-0.1	0.2	0.4	-0.0
Asthma (self-reported)	8.0	16.0	19.6	3.4	4.1	4.3	4.0	3.7	4.4	4.4	4.1	4.4	3.6	4.1	4.0	3.7	3.2	-4.3
Osteoporosis (self-reported)	0.6	0.8	3.2	1.3	0.7	1.0	0.6	-0.0	0.9	0.7	0.5	0.7	1.1	1.8	0.3	0.8	0.4	-0.8
Osteoarthritis (self-reported)	2.3	3.0	4.4	1.0	2.0	1.9	2.1	2.0	1.8	1.5	1.8	1.6	1.8	1.1	1.5	2.0	1.7	-1.5
Medication: Aspirin	3.4	4.5	5.9	1.6	2.1	2.4	2.4	2.4	2.4	2.2	1.6	2.4	1.9	2.0	2.0	2.3	1.6	-2.1
Medication: Gliclazide	1.0	1.2	2.6	0.7	1.3	1.1	1.3	1.6	0.9	0.7	0.7	1.1	1.6	0.7	1.2	1.2	-0.2	-0.9
Illnesses of father: None of the above (group 1)	5.4	6.6	8.7	-2.3	-2.6	-2.9	-2.6	-2.0	-2.8	-2.8	-1.9	-2.9	-2.5	-2.9	-2.9	-2.4	-1.9	2.8
Smoking status: Current	0.1	0.2	0.7	-0.3	0.1	-0.2	-0.2	0.0	-0.1	-0.0	0.7	0.0	0.8	-0.9	0.3	0.0	-0.6	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.6	5.4	9.1	2.7	2.1	2.2	2.4	2.6	2.7	2.4	1.7	2.2	1.5	3.0	2.5	2.1	2.1	-2.1
Whole body water mass	1.9	11.1	17.4	-3.4	-3.1	-4.2	-3.4	-3.2	-3.3	-4.0	-1.8	-3.7	-3.2	-3.4	-3.2	-3.4	-2.6	3.4
Leg predicted mass (right)	1.4	7.3	12.5	-2.6	-2.5	-3.5	-2.8	-2.8	-2.7	-3.2	-1.4	-3.0	-2.5	-2.7	-2.4	-2.8	-2.1	2.7
Arm fat mass (left)	2.6	10.7	14.9	3.1	3.6	3.0	3.3	3.1	3.1	2.7	3.9	3.4	3.4	3.7	3.3	3.2	3.0	-3.3
Number of self-reported non-cancer illnesses	4.1	7.1	9.3	2.5	2.6	2.7	2.7	3.0	3.0	2.7	2.7	2.8	2.7	3.0	2.5	2.3	1.4	-2.9
Average weekly champagne plus white wine intake	0.9	1.2	1.9	-1.2	-0.9	-1.0	-0.6	-1.0	-1.3	-1.3	-1.3	-0.9	-1.1	-1.4	-0.9	-0.9	-1.3	1.2
Miserableness	0.0	0.1	0.5	-0.5	0.1	0.0	0.1	-0.1	0.3	0.3	-0.0	0.3	-0.0	0.2	0.3	-0.2	-0.7	0.1
Guilty feelings	0.0	0.1	0.3	-0.4	0.2	0.1	0.1	0.2	0.2	0.0	0.2	0.1	0.6	0.1	0.1	0.2	-0.5	-0.1
Wears glasses or contact lenses	0.2	0.2	0.8	0.8	0.4	0.6	0.4	-0.1	0.5	0.0	-0.0	0.5	0.3	0.6	0.1	0.4	-0.1	-0.9
Ever taken oral contraceptive pill	1.3	1.4	1.9	-1.1	-1.2	-1.1	-1.3	-1.1	-1.3	-0.9	-0.2	-1.3	-1.4	-1.2	-1.4	-1.3	-1.2	1.2
Hearing aid user	2.2	2.4	4.4	1.1	1.8	1.8	2.0	2.1	1.5	1.4	1.6	1.7	1.1	1.5	1.6	1.5	1.3	-1.3
Mother’s age at death	0.4	0.5	1.8	-0.2	-0.9	-0.8	-0.6	-0.7	-0.7	-1.0	-0.5	-0.6	-1.3	0.0	-1.2	-0.9	-0.1	0.1
Financial situation satisfaction	1.7	2.1	3.0	1.1	1.6	1.6	1.6	1.7	1.3	1.7	0.5	1.6	1.2	1.1	1.6	1.7	1.6	-1.1
Tinnitus: Yes, now most or all of the time	1.6	1.9	3.0	1.0	1.3	1.6	1.4	1.4	1.7	1.7	1.0	1.5	1.0	1.7	1.4	1.1	1.0	-1.2
Commuting to job workplace: Public transport	4.2	5.0	6.9	2.4	2.3	2.4	2.5	2.6	2.4	2.4	1.2	2.4	2.0	2.0	2.4	2.3	1.8	-2.1
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	-0.2	-0.7	-0.2	-0.5	-0.4	-0.0	0.1	-0.6	-0.2	-0.8	0.6	-0.7	-0.6	-0.2	0.0
Medication: Blood pressure	4.4	8.3	12.7	2.7	2.7	2.9	2.7	2.8	3.0	2.5	2.9	3.1	3.3	3.5	3.1	2.3	1.7	-3.6
Pain type(s) experienced in last month: Hip pain	8.1	10.2	11.8	2.9	3.4	3.4	3.4	3.4	3.2	3.0	3.0	3.1	3.4	2.8	3.1	3.4	3.1	-3.2
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.0	-1.3	-1.1	-1.1	-1.1	-0.5	-0.9	-1.1	-0.8	-0.8	-1.4	-1.0	-1.4	-1.1	-0.6	0.5
High cholesterol (Self-reported)	4.0	7.1	9.4	2.3	2.6	3.0	2.8	2.8	2.8	2.6	2.2	3.1	2.7	2.9	2.9	2.6	1.6	-2.9
Medication: Bendroflumethiazide	1.5	2.3	3.5	1.5	1.5	1.4	1.5	1.7	1.6	1.1	1.7	1.6	1.7	1.5	1.9	1.2	0.0	-1.8
Medication: Paracetamol	0.3	0.5	1.6	0.4	0.9	0.8	0.4	1.0	0.2	0.0	1.3	0.6	0.9	0.2	0.5	0.9	0.1	-1.0
Medication: Lisinopril	0.4	0.5	1.3	0.6	0.7	0.7	0.8	0.9	0.7	0.7	1.1	0.7	0.7	0.9	0.6	0.3	-0.1	-0.9
Medication: Atorvastatin	6.2	7.6	11.5	1.9	2.8	3.1	2.8	2.8	2.7	2.6	2.9	2.8	2.9	3.4	2.5	2.8	2.5	-2.6
Illnesses of father: High blood pressure	1.7	2.1	3.7	0.9	1.4	1.4	1.2	1.1	1.6	1.5	1.6	1.3	1.7	1.9	1.7	1.1	1.6	-1.3
Alcohol drinker status: Never	3.4	4.1	6.7	1.4	2.0	2.4	1.9	2.2	2.1	1.7	1.8	2.1	2.2	2.6	1.9	1.9	1.7	-2.3
Ever smoked	2.6	4.6	7.5	-2.2	-2.0	-2.3	-2.3	-2.4	-2.2	-2.6	-1.2	-2.2	-1.3	-2.7	-2.1	-2.1	-2.4	1.8
Basal metabolic rate	1.1	6.2	10.8	-2.6	-2.2	-3.3	-2.5	-2.4	-2.5	-3.1	-1.0	-2.8	-2.3	-2.4	-2.3	-2.6	-1.8	2.5
Leg fat percentage (left)	7.1	25.7	29.7	4.9	5.4	5.1	5.2	4.8	4.8	4.6	5.2	5.4	5.2	5.5	5.0	5.2	4.9	-5.0
Arm fat-free mass (left)	1.2	6.3	10.3	-2.9	-2.2	-3.2	-2.5	-2.4	-2.5	-3.2	-1.1	-2.8	-2.2	-2.5	-2.4	-2.6	-1.7	2.6
Number of operations (self-reported)	4.4	6.5	8.9	2.3	2.8	2.6	3.0	2.9	2.7	2.5	2.0	2.6	2.5	2.4	2.7	2.7	2.1	-2.0
Average weekly beer plus cider intake	0.2	0.3	0.9	-0.3	-0.6	-0.7	-0.8	-0.4	-0.6	-0.3	0.3	-0.5	-0.1	-0.9	-0.8	-0.8	-0.1	0.5
Irritability	0.4	0.7	1.9	-1.4	-0.7	-1.0	-0.6	-0.8	-0.7	-0.8	-0.3	-0.9	-0.7	-0.7	-0.7	-1.1	-0.4	0.9
Risk taking	2.2	3.2	4.9	-2.2	-1.7	-1.8	-1.7	-1.5	-1.7	-1.9	-1.5	-1.8	-1.7	-1.9	-2.1	-1.6	-1.8	1.9
Ever had prostate specific antigen (PSA) test	4.5	5.2	7.7	-2.5	-2.4	-2.1	-2.2	-1.8	-2.4	-2.5	-2.4	-2.5	-2.4	-2.1	-2.8	-2.2	-1.9	2.1
Fractured/broken bones in last 5 years	0.0	0.1	0.2	-0.3	0.1	-0.2	-0.3	-0.2	-0.3	-0.4	0.4	-0.2	0.2	-0.4	-0.1	0.1	0.1	0.1
Age started oral contraceptive pill	0.1	0.1	0.6	0.3	0.2	0.2	0.3	0.4	0.3	-0.3	0.7	-0.0	-0.4	0.7	-0.0	0.0	0.5	-0.3
Diastolic blood pressure, automated reading	7.1	22.0	35.9	4.6	4.2	4.8	4.3	5.5	4.6	4.0	4.7	4.9	4.5	6.0	4.5	4.1	3.5	-5.5
Ever depressed for a whole week	0.2	0.3	1.1	0.2	0.4	0.4	0.8	1.1	0.9	0.6	-0.4	0.4	-0.1	-0.1	0.5	0.6	-0.0	0.0
Unable to work because of sickness or disability	0.1	0.1	0.5	0.3	0.3	0.2	0.3	0.7	0.0	-0.0	0.3	0.1	0.6	0.1	-0.1	0.4	0.3	-0.0
Commuting to job workplace: Cycle	4.5	5.5	7.4	-2.4	-2.3	-2.2	-2.1	-2.4	-2.4	-2.3	-2.3	-2.2	-2.5	-2.7	-2.3	-1.8	-2.6	2.3
Myopia	0.3	0.4	1.0	-0.2	-0.4	-0.4	-0.6	-0.3	-0.5	-0.9	0.0	-0.6	-0.5	-0.8	-0.8	-1.0	-1.0	-0.0
Vascular/heart problems diagnosed by doctor	4.9	13.5	22.1	-3.7	-3.3	-3.6	-3.4	-3.7	-4.0	-3.2	-3.7	-3.8	-4.0	-4.7	-3.9	-2.8	-1.6	4.5
Cholesterol lowering medication	2.9	4.2	6.2	1.6	2.2	2.3	2.2	2.0	2.0	1.8	1.5	2.5	2.4	1.9	2.4	2.1	1.1	-2.3
Medication: Omeprazole (e.g. Zanprol)	2.7	3.3	4.4	1.6	1.8	1.9	1.9	2.1	1.8	1.6	1.6	1.8	1.8	2.0	1.9	1.9	1.3	-2.0
Pain experienced in last month	3.9	6.5	10.4	-1.9	-2.5	-2.7	-2.9	-3.2	-2.7	-2.5	-1.8	-2.5	-2.3	-2.5	-2.5	-2.5	-2.9	2.4
Supplements: Calcium	1.0	1.1	2.3	-1.3	-1.0	-0.6	-0.8	-0.8	-0.9	-1.0	-1.1	-0.9	-1.5	-0.8	-1.2	-0.9	-1.3	0.9
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	-0.3	0.1	0.0	0.2	0.3	-0.1	-0.2	0.5	0.2	0.1	-0.2	-0.5	0.1	0.4	0.0
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.4	-0.3	0.2	0.3	0.4	0.5	0.4	-0.0	0.2	0.5	0.7	0.4	0.2	0.1	-0.2	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.7	0.9	1.2	1.3	0.9	0.7	1.0	0.9	1.2	0.9	1.3	1.3	0.9	0.8	0.5	-0.7
Heart disease (siblings)	6.7	8.2	11.6	2.7	2.7	2.8	2.9	2.8	3.4	3.0	2.6	3.1	2.8	2.9	3.2	2.6	2.3	-3.0
Alcohol drinker status: Previous	0.1	0.1	0.4	-0.1	-0.0	-0.1	0.1	-0.1	0.2	0.6	-0.3	0.0	-0.5	-0.6	0.1	0.3	-0.4	0.6
Pack years of smoking	4.4	6.4	9.1	2.4	2.7	2.4	2.3	2.5	2.5	2.4	2.7	2.2	3.0	2.2	2.6	2.4	3.0	-2.5
Impedance of whole body	0.4	2.0	4.5	0.9	1.4	1.8	1.5	2.1	1.4	1.9	0.8	1.5	1.0	0.9	1.3	1.3	1.1	-1.3
Leg fat mass (left)	3.1	12.0	16.3	3.3	3.8	3.1	3.5	3.4	3.2	2.8	4.0	3.5	3.6	3.9	3.4	3.5	3.4	-3.4
Arm predicted mass (left)	1.1	5.4	9.3	-2.7	-2.0	-3.1	-2.3	-2.1	-2.3	-3.0	-0.7	-2.7	-2.0	-2.3	-2.2	-2.4	-1.5	2.4