Best TWAS P=8.1e-12 · Best GWAS P=4.15e-12 conditioned to 0.513
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CHST10 | 0.05 | 0.02 | blup | 474 | 0.04 | 1.0e-05 | 5.0 | -5.2 | 1.6e-07 | 0.60 | 0.51 | 0.48 | FALSE |
| 2 | GTEx | Adrenal Gland | CHST10 | 0.18 | 0.04 | lasso | 4 | 0.05 | 5.6e-03 | -5.5 | 5.6 | 2.2e-08 | -0.69 | 0.30 | 0.22 | FALSE |
| 3 | GTEx | Artery Aorta | AFF3 | 0.14 | 0.06 | lasso | 5 | 0.07 | 1.2e-04 | -6.9 | -6.8 | 8.1e-12 | 0.84 | 0.01 | 0.99 | TRUE |
| 4 | GTEx | Muscle Skeletal | LONRF2 | 0.07 | 0.08 | lasso | 4 | 0.08 | 2.5e-08 | -5.6 | -5.6 | 2.4e-08 | 0.54 | 0.96 | 0.04 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | LONRF2 | 0.05 | 0.03 | lasso | 2 | 0.02 | 9.3e-03 | 5.7 | -6.0 | 1.8e-09 | 0.56 | 0.32 | 0.10 | TRUE |
| 6 | GTEx | Thyroid | CHST10 | 0.05 | 0.05 | lasso | 5 | 0.03 | 2.6e-03 | -5.5 | -6.1 | 1.4e-09 | 0.60 | 0.38 | 0.41 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LONRF2 | 0.06 | 0.04 | blup | 69 | 0.04 | 3.4e-05 | 5.2 | -6.0 | 2.7e-09 | 0.68 | 0.28 | 0.71 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LONRF2 | 0.05 | 0.08 | lasso | 2 | 0.08 | 2.9e-05 | 5.5 | -5.4 | 5.9e-08 | 0.65 | 0.16 | 0.37 | FALSE |