Best TWAS P=8.15e-22 · Best GWAS P=1.56e-22 conditioned to 0.111
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 | GTEx | Skin Sun Exposed Lower leg | MLLT10 | 0.06 | 0.02 | lasso | 4 | 0.03 | 8.0e-04 | 9.4 | -9.6 | 8.1e-22 | -0.94 | 0.02 | 0.98 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | NEBL | 0.07 | 0.01 | blup | 662 | 0.03 | 9.7e-05 | -4.5 | -5.8 | 5.1e-09 | -0.03 | 0.76 | 0.01 | TRUE |
| 5 | GTEx | Skin Sun Exposed Lower leg | CASC10 | 0.08 | 0.02 | lasso | 5 | 0.01 | 6.1e-02 | 8.0 | 9.0 | 2.9e-19 | 0.90 | 0.08 | 0.83 | FALSE |
| 6 | GTEx | Spleen | MLLT10 | 0.16 | 0.02 | lasso | 7 | 0.02 | 1.0e-01 | 8.0 | -8.9 | 5.1e-19 | -0.92 | 0.03 | 0.54 | FALSE |
| 3 | GTEx | Artery Tibial | CASC10 | 0.05 | 0.06 | lasso | 4 | 0.02 | 1.3e-02 | 3.7 | 6.0 | 1.6e-09 | 0.52 | 0.24 | 0.51 | FALSE |
| 1 | CommonMind | Brain Pre-frontal Cortex | LOC100499489 | 0.06 | 0.00 | bslmm | 297 | 0.02 | 1.2e-03 | 0.9 | -5.1 | 2.9e-07 | -0.49 | 0.02 | 0.75 | FALSE |