[Hub]/) : Traits : Leg fat mass (right) :

chr11:64,501,991-66,919,278

Best TWAS P=3.57e-12 · Best GWAS P=5.92e-16 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CFL1 0.04 0.00 bslmm 350 0.02 3.3e-03 3.1 -5.4 6.5e-08 0.41 0.08 0.28 FALSE
2 CommonMind Brain Pre-frontal Cortex FIBP 0.08 0.11 enet 20 0.12 8.1e-14 5.1 7.0 3.6e-12 -0.34 1.00 0.00 TRUE
3 CommonMind Brain Pre-frontal Cortex SNX32 0.46 0.36 lasso 8 0.39 1.9e-50 5.9 5.9 4.5e-09 -0.16 1.00 0.00 FALSE
4 GTEx Adipose Subcutaneous CTSW 0.30 0.18 lasso 6 0.16 3.9e-13 5.1 -5.2 1.9e-07 0.13 1.00 0.00 FALSE
5 GTEx Adipose Visceral Omentum CTSW 0.22 0.20 lasso 11 0.19 5.1e-10 5.1 -5.2 2.1e-07 0.15 1.00 0.00 FALSE
6 GTEx Adrenal Gland CTSW 0.13 0.08 lasso 12 0.06 3.0e-03 5.5 -6.2 7.7e-10 0.22 0.31 0.18 FALSE
7 GTEx Artery Coronary FIBP 0.13 0.01 lasso 5 0.04 1.3e-02 5.1 5.2 2.5e-07 -0.18 0.16 0.18 FALSE
8 GTEx Brain Cortex PACS1 0.19 0.11 lasso 9 0.08 2.9e-03 4.9 -5.5 4.8e-08 0.60 0.26 0.29 FALSE
9 GTEx Breast Mammary Tissue CTSW 0.25 0.19 lasso 8 0.16 1.3e-08 5.1 -5.4 6.1e-08 0.13 1.00 0.00 FALSE
10 GTEx Breast Mammary Tissue (Male) LTBP3 0.11 -0.01 enet 26 -0.01 5.8e-01 5.3 5.8 8.8e-09 -0.08 0.03 0.25 FALSE
11 GTEx Breast Mammary Tissue (Male) NEAT1 0.27 0.01 enet 29 0.03 6.3e-02 5.1 6.0 2.0e-09 -0.16 0.04 0.26 FALSE
12 GTEx Cells EBV-transformed lymphocytes FIBP 0.40 0.21 enet 26 0.29 4.3e-10 5.1 5.8 6.0e-09 -0.17 0.99 0.00 FALSE
13 GTEx Cells Transformed fibroblasts FIBP 0.20 0.13 lasso 5 0.17 1.7e-12 5.1 5.2 1.8e-07 -0.13 1.00 0.00 FALSE
14 GTEx Cells Transformed fibroblasts EFEMP2 0.06 0.06 lasso 3 0.07 7.8e-06 5.2 5.6 2.1e-08 -0.23 0.81 0.01 FALSE
15 GTEx Colon Transverse CTSW 0.37 0.27 lasso 8 0.26 1.5e-12 5.1 -5.6 2.3e-08 0.17 1.00 0.00 FALSE
16 GTEx Esophagus Muscularis YIF1A 0.11 0.05 enet 11 0.04 2.4e-03 4.6 -5.4 6.7e-08 0.57 0.83 0.15 TRUE
17 GTEx Esophagus Muscularis CNIH2 0.06 0.02 lasso 8 0.02 2.8e-02 4.2 5.4 7.5e-08 -0.53 0.09 0.54 FALSE
18 GTEx Esophagus Muscularis CTD-3074O7.5 0.22 0.02 enet 17 0.09 3.7e-06 -2.6 6.4 1.8e-10 -0.50 0.31 0.44 TRUE
19 GTEx Heart Atrial Appendage KLC2 0.10 0.04 lasso 8 0.09 1.1e-04 4.7 -5.5 3.6e-08 0.56 0.26 0.43 FALSE
20 GTEx Heart Atrial Appendage RP11-867G23.1 0.19 0.13 lasso 5 0.11 1.6e-05 -6.2 -5.8 5.4e-09 0.66 0.12 0.79 FALSE
21 GTEx Heart Left Ventricle FIBP 0.12 0.09 lasso 3 0.07 9.8e-05 5.1 5.6 2.5e-08 -0.17 0.87 0.01 FALSE
22 GTEx Liver CTSW 0.27 0.03 lasso 13 0.02 1.0e-01 5.1 -5.8 8.2e-09 0.23 0.07 0.06 FALSE
23 GTEx Muscle Skeletal FIBP 0.12 0.13 enet 10 0.13 2.6e-12 5.1 5.5 4.3e-08 -0.17 1.00 0.00 FALSE
24 GTEx Nerve Tibial CTSW 0.22 0.19 lasso 7 0.18 1.3e-12 5.1 -5.2 1.9e-07 0.13 1.00 0.00 FALSE
25 GTEx Pancreas CTSW 0.13 0.11 lasso 3 0.08 4.0e-04 5.1 -5.1 2.7e-07 0.12 0.33 0.03 FALSE
26 GTEx Prostate CTSW 0.29 0.26 lasso 8 0.26 2.9e-07 5.1 -5.3 1.3e-07 0.13 0.57 0.03 FALSE
27 GTEx Skin Not Sun Exposed Suprapubic CTSW 0.27 0.22 lasso 12 0.22 1.9e-12 5.1 -5.7 1.5e-08 0.17 1.00 0.00 FALSE
28 GTEx Skin Sun Exposed Lower leg CTSW 0.19 0.19 lasso 6 0.18 1.1e-14 5.1 -5.2 1.7e-07 0.13 1.00 0.00 FALSE
29 GTEx Skin Sun Exposed Lower leg RP11-867G23.1 0.06 0.06 enet 7 0.02 1.3e-02 5.4 -5.7 1.4e-08 0.69 0.25 0.50 FALSE
30 GTEx Spleen CTSW 0.30 0.31 lasso 2 0.26 1.9e-07 5.1 -5.2 2.6e-07 0.13 0.97 0.00 FALSE
31 GTEx Stomach CTSW 0.18 0.20 lasso 7 0.19 1.7e-09 5.1 -5.1 2.7e-07 0.13 1.00 0.00 FALSE
32 GTEx Thyroid CTSW 0.18 0.22 lasso 2 0.21 4.6e-16 5.1 -5.3 9.6e-08 0.14 1.00 0.00 FALSE
33 GTEx Thyroid PACS1 0.09 0.04 enet 16 0.09 2.8e-07 -7.9 -6.1 1.4e-09 0.79 0.03 0.97 TRUE
34 GTEx Uterus PACS1 0.21 -0.01 enet 21 0.05 3.6e-02 4.3 -5.4 7.4e-08 0.42 0.07 0.31 FALSE
35 GTEx Vagina CFL1 0.18 0.09 lasso 9 0.07 9.0e-03 4.4 -5.3 9.3e-08 0.53 0.12 0.11 FALSE
36 METSIM Adipose FIBP 0.05 0.02 blup 344 0.02 1.0e-03 5.1 5.5 3.9e-08 -0.39 0.96 0.01 FALSE
37 METSIM Adipose KLC2 0.06 0.06 blup 323 0.05 1.2e-08 4.7 -5.4 7.7e-08 0.53 1.00 0.00 FALSE
38 ROSMAP Brain Pre-frontal Cortex FIBP 0.13 0.13 lasso 3 0.15 5.8e-19 5.1 5.2 2.2e-07 -0.13 1.00 0.00 FALSE
39 ROSMAP Brain Pre-frontal Cortex CTSW 0.06 0.03 bslmm 328 0.03 3.6e-05 5.4 -5.4 8.3e-08 0.12 0.60 0.02 TRUE
40 ROSMAP Brain Pre-frontal Cortex SNX32 0.50 0.53 lasso 13 0.54 1.1e-81 5.9 5.6 2.0e-08 -0.13 1.00 0.00 FALSE
41 The Cancer Genome Atlas Bladder Urothelial Carcinoma CTSW 0.12 0.16 enet 12 0.17 5.6e-14 5.1 -5.2 1.8e-07 0.18 0.11 0.88 TRUE
42 The Cancer Genome Atlas Bladder Urothelial Carcinoma SNX32 0.05 0.05 blup 60 0.03 1.1e-03 5.9 5.7 1.1e-08 -0.19 0.01 0.98 FALSE
43 The Cancer Genome Atlas Breast Invasive Carcinoma CTSW 0.25 0.39 blup 44 0.41 7.3e-91 5.1 -5.6 2.1e-08 0.17 0.12 0.88 FALSE
44 The Cancer Genome Atlas Breast Invasive Carcinoma PACS1 0.02 0.02 blup 77 0.02 8.5e-05 4.7 -5.2 2.2e-07 0.52 0.50 0.11 FALSE
45 The Cancer Genome Atlas Breast Invasive Carcinoma SNX32 0.15 0.17 blup 60 0.17 2.9e-34 5.9 5.8 5.6e-09 -0.16 0.00 1.00 TRUE
46 The Cancer Genome Atlas Colon Adenocarcinoma SNX32 0.11 0.08 enet 5 0.07 9.7e-05 5.1 5.3 8.8e-08 -0.14 0.01 0.99 FALSE
47 The Cancer Genome Atlas Glioblastoma Multiforme CTSW 0.16 0.18 enet 16 0.19 2.3e-06 5.5 -6.3 2.5e-10 0.23 0.04 0.91 TRUE
48 The Cancer Genome Atlas Glioblastoma Multiforme SNX32 0.13 0.05 blup 60 0.09 1.1e-03 5.9 5.2 2.5e-07 -0.20 0.01 0.90 FALSE
49 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma CTSW 0.31 0.32 lasso 4 0.34 1.8e-39 5.2 -5.3 1.2e-07 0.13 0.11 0.88 FALSE
50 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SNX32 0.15 0.14 enet 8 0.15 2.5e-16 4.0 5.4 6.9e-08 -0.16 0.01 0.99 FALSE
51 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CNIH2 0.03 0.00 enet 4 0.02 6.4e-03 -4.4 5.4 5.7e-08 -0.58 0.06 0.13 FALSE
52 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CTSW 0.23 0.25 lasso 6 0.25 3.2e-28 5.1 -5.1 2.9e-07 0.13 0.14 0.86 FALSE
53 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SNX32 0.15 0.11 blup 60 0.15 6.0e-17 5.9 5.6 2.6e-08 -0.14 0.00 1.00 FALSE
54 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma CTSW 0.32 0.26 lasso 1 0.26 4.3e-15 5.4 -5.4 5.2e-08 0.12 0.08 0.92 FALSE
55 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma FIBP 0.05 0.01 blup 44 0.02 1.5e-02 5.9 5.4 6.2e-08 -0.16 0.01 0.75 FALSE
56 The Cancer Genome Atlas Brain Lower Grade Glioma CTSW 0.13 0.14 blup 44 0.14 7.0e-16 5.1 -5.3 1.3e-07 0.11 0.07 0.93 FALSE
57 The Cancer Genome Atlas Brain Lower Grade Glioma EFEMP2 0.01 0.00 blup 45 0.01 3.0e-02 4.0 5.8 7.9e-09 -0.23 0.02 0.55 FALSE
58 The Cancer Genome Atlas Brain Lower Grade Glioma FIBP 0.04 0.04 lasso 3 0.04 1.2e-05 5.9 5.9 3.0e-09 -0.13 0.01 0.99 FALSE
59 The Cancer Genome Atlas Brain Lower Grade Glioma SNX32 0.15 0.27 enet 23 0.26 6.1e-30 5.9 5.4 7.7e-08 -0.14 0.00 1.00 FALSE
60 The Cancer Genome Atlas Liver Hepatocellular Carcinoma CTSW 0.63 0.41 lasso 8 0.42 1.2e-21 5.4 -5.4 7.3e-08 0.12 0.09 0.91 FALSE
61 The Cancer Genome Atlas Lung Adenocarcinoma CTSW 0.23 0.29 lasso 7 0.29 1.0e-33 5.2 -5.2 1.7e-07 0.13 0.10 0.90 FALSE
62 The Cancer Genome Atlas Lung Adenocarcinoma FIBP 0.02 0.01 blup 45 0.02 1.3e-03 5.4 6.0 2.1e-09 -0.25 0.04 0.62 FALSE
63 The Cancer Genome Atlas Lung Adenocarcinoma SNX32 0.14 0.09 blup 60 0.13 8.8e-15 5.9 6.1 1.3e-09 -0.16 0.01 0.99 FALSE
64 The Cancer Genome Atlas Lung Squamous Cell Carcinoma CTSW 0.25 0.34 enet 14 0.34 4.1e-40 5.2 -5.4 7.5e-08 0.14 0.12 0.88 FALSE
65 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SNX32 0.22 0.21 enet 16 0.24 6.2e-27 5.9 5.6 2.0e-08 -0.17 0.00 1.00 FALSE
66 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma CTSW 0.20 0.23 lasso 9 0.23 1.5e-15 5.1 -5.2 1.5e-07 0.13 0.10 0.90 FALSE
67 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma SNX32 0.08 0.10 blup 60 0.11 6.0e-08 5.9 6.0 2.1e-09 -0.19 0.01 0.99 FALSE
68 The Cancer Genome Atlas Pancreatic Adenocarcinoma CTSW 0.30 0.23 lasso 11 0.24 1.7e-10 5.1 -5.2 1.7e-07 0.14 0.07 0.93 FALSE
69 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma SNX32 0.30 0.19 lasso 1 0.14 3.9e-06 5.9 5.9 3.1e-09 -0.12 0.00 1.00 FALSE
70 The Cancer Genome Atlas Prostate Adenocarcinoma CTSW 0.29 0.49 enet 12 0.49 3.4e-58 5.1 -5.2 2.2e-07 0.13 0.13 0.87 FALSE
71 The Cancer Genome Atlas Prostate Adenocarcinoma SNX32 0.07 0.08 lasso 4 0.10 2.0e-10 5.1 5.1 2.7e-07 -0.14 0.01 0.99 FALSE
72 The Cancer Genome Atlas Rectum Adenocarcinoma CTSW 0.21 0.05 blup 39 0.07 9.1e-03 5.1 -5.1 2.9e-07 0.16 0.04 0.44 FALSE
73 The Cancer Genome Atlas Soft Tissue Sarcoma CTSW 0.18 0.22 lasso 3 0.22 4.1e-13 5.1 -5.1 3.0e-07 0.13 0.13 0.87 FALSE
74 The Cancer Genome Atlas Soft Tissue Sarcoma SNX32 0.08 0.08 lasso 2 0.10 1.5e-06 5.2 5.9 4.0e-09 -0.21 0.04 0.95 FALSE
75 The Cancer Genome Atlas Stomach Adenocarcinoma CTSW 0.24 0.35 lasso 7 0.36 3.0e-27 5.4 -5.3 1.4e-07 0.15 0.07 0.93 FALSE
76 The Cancer Genome Atlas Stomach Adenocarcinoma SNX32 0.12 0.13 blup 60 0.13 1.2e-09 5.1 6.3 3.3e-10 -0.16 0.05 0.95 FALSE
77 The Cancer Genome Atlas Testicular Germ Cell Tumors CTSW 0.26 0.29 lasso 9 0.27 4.7e-10 5.1 -5.4 6.6e-08 0.14 0.12 0.88 FALSE
78 The Cancer Genome Atlas Thyroid Carcinoma CTSW 0.25 0.37 lasso 8 0.37 5.2e-38 5.2 -5.2 2.0e-07 0.14 0.13 0.87 FALSE
79 The Cancer Genome Atlas Thyroid Carcinoma SNX32 0.23 0.26 lasso 7 0.25 6.4e-24 5.9 5.8 5.0e-09 -0.14 0.00 1.00 FALSE
80 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma CTSW 0.24 0.21 enet 21 0.24 2.9e-07 5.1 -5.7 1.3e-08 0.17 0.07 0.93 FALSE