[Hub]/) : Traits : Leg fat mass (right) : ←

chr22:37,528,576-39,663,066

Best TWAS P=5.25e-11 · Best GWAS P=1.22e-11 conditioned to 0.329

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	BAIAP2L2	0.11	0.03	lasso	5	0.04	1.8e-04	5.1	-6.1	1.4e-09	-0.71	0.02	0.92	FALSE
2	GTEx	Artery Aorta	C22orf23	0.10	0.01	enet	24	0.02	1.6e-02	3.3	5.9	3.3e-09	0.34	0.26	0.08	TRUE
3	GTEx	Artery Aorta	PLA2G6	0.10	0.02	enet	9	0.02	4.5e-02	4.1	6.5	7.3e-11	0.68	0.09	0.50	FALSE
4	GTEx	Artery Aorta	TMEM184B	0.17	0.07	enet	34	0.03	1.2e-02	5.9	-5.8	8.8e-09	-0.68	0.07	0.70	FALSE
5	GTEx	Artery Aorta	AL021977.1	0.13	0.00	enet	17	0.01	8.7e-02	5.9	-6.6	5.2e-11	-0.73	0.04	0.68	TRUE
6	GTEx	Brain Cortex	TMEM184B	0.29	0.12	lasso	7	0.09	1.6e-03	5.9	-6.1	8.3e-10	-0.91	0.01	0.88	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	PLA2G6	0.28	0.17	enet	13	0.18	1.3e-06	-4.8	5.9	4.0e-09	0.69	0.35	0.45	FALSE
8	GTEx	Cells Transformed fibroblasts	PLA2G6	0.23	0.09	lasso	9	0.10	9.9e-08	5.4	5.9	3.8e-09	0.81	0.73	0.27	FALSE
9	GTEx	Esophagus Gastroesophageal Junction	PLA2G6	0.28	0.24	lasso	5	0.23	1.1e-08	-4.8	5.3	1.4e-07	0.64	0.76	0.12	FALSE
10	GTEx	Esophagus Mucosa	PLA2G6	0.22	0.02	lasso	6	0.04	1.9e-03	5.4	5.8	7.4e-09	0.77	0.11	0.86	FALSE
11	GTEx	Esophagus Muscularis	PLA2G6	0.12	0.00	enet	18	0.01	1.4e-01	5.4	5.2	2.6e-07	0.62	0.09	0.25	FALSE
12	GTEx	Esophagus Muscularis	TMEM184B	0.11	0.01	enet	10	0.06	2.7e-04	3.3	-5.3	1.4e-07	-0.60	0.27	0.18	FALSE
13	GTEx	Muscle Skeletal	DMC1	0.13	0.01	enet	17	0.04	3.3e-05	5.1	5.4	7.7e-08	0.59	0.06	0.70	FALSE
14	GTEx	Nerve Tibial	PLA2G6	0.34	0.08	lasso	8	0.11	2.9e-08	-4.8	5.6	2.6e-08	0.72	0.87	0.13	FALSE
15	GTEx	Nerve Tibial	MAFF	0.14	0.06	lasso	3	0.05	1.2e-04	6.6	-6.5	6.6e-11	-0.98	0.01	0.98	FALSE
16	GTEx	Skin Sun Exposed Lower leg	BAIAP2L2	0.09	0.09	lasso	4	0.09	5.5e-08	5.2	-5.6	2.3e-08	-0.74	0.38	0.62	FALSE
17	GTEx	Thyroid	PLA2G6	0.34	0.20	lasso	5	0.18	4.5e-14	-4.8	5.4	8.3e-08	0.67	0.99	0.01	FALSE
18	GTEx	Thyroid	TMEM184B	0.19	0.16	lasso	7	0.18	1.0e-13	4.2	-5.5	5.0e-08	-0.67	0.99	0.01	FALSE
19	GTEx	Thyroid	AL021977.1	0.20	0.11	lasso	6	0.12	2.7e-09	4.1	-5.5	4.0e-08	-0.66	0.97	0.03	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	ANKRD54	0.03	0.00	blup	397	0.01	2.2e-02	2.6	-5.5	4.8e-08	-0.28	0.19	0.06	FALSE
21	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ANKRD54	0.20	0.06	lasso	1	0.06	3.0e-07	-5.2	-5.2	2.2e-07	-0.17	0.00	1.00	FALSE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PLA2G6	0.05	0.01	blup	76	0.01	7.7e-02	6.8	6.5	6.7e-11	0.83	0.01	0.86	TRUE
23	The Cancer Genome Atlas	Thyroid Carcinoma	PLA2G6	0.03	0.02	lasso	2	0.03	6.5e-04	5.7	5.7	1.2e-08	0.81	0.09	0.17	FALSE