TWAS hub - C22orf23

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1030	0.0430	6.5e-04	0.011	NA	0.025	NA	0.015	7.2e-02	NA	0.01600	NA	4.7e-02
2	GTEx	Artery Tibial	0.0846	0.0311	4.2e-05	0.050	NA	0.040	NA	0.055	8.2e-05	NA	0.00039	NA	4.2e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Breast Cancer	9.3	22.4	33.3	5.8	3.4
Past tobacco smoking	9.2	16.9	20.1	4.5	3.7
Lung cancer (father)	8.9	10.4	12.3	-2.9	-3.5
Mean time to correctly identify matches	8.5	16.1	20.0	-4.5	-3.5
Intelligence (Savage-Jansen 2018)	7.0	21.4	26.5	-5.1	-4.0
Number of incorrect matches in round	6.6	11.0	12.9	3.6	3.0
Ever smoked	6.5	11.4	13.5	-3.7	-3.1
Body fat percentage	6.4	25.4	40.7	6.4	3.2
Reaction Time	6.3	12.0	15.5	-3.9	-2.9
Leg fat percentage (right)	6.3	22.7	32.8	5.7	3.5
Smoking status: Previous	6.3	9.5	11.4	-3.4	-2.7
Smoking Status	6.2	14.7	16.4	-4.1	-3.6
Diabetes (father)	6.2	7.7	10.3	-3.2	-2.2
Leg fat mass (right)	6.0	23.3	35.0	5.9	3.4
Age when periods started (menarche)	5.9	14.2	17.9	-4.2	-3.2
Arm fat percentage (left)	5.7	22.7	34.4	5.9	3.3
Verbal and Numeric Reasoning (VNR)	5.6	13.4	17.0	-4.1	-3.1
Trunk fat percentage	5.6	22.5	38.4	6.2	2.6
Arm fat percentage (right)	5.6	22.2	33.7	5.8	3.3
Whole body fat mass	5.4	22.7	36.3	6.0	3.0
Leg fat percentage (left)	5.3	19.2	28.7	5.4	3.1
BMI	5.2	30.0	40.4	6.4	4.4
Leg fat mass (left)	5.2	20.3	31.1	5.6	3.1
Fluid intelligence score	4.8	10.0	12.9	-3.6	-2.7
Heel T-Score	4.7	37.5	45.4	5.4	6.7
Loud music exposure frequency	4.6	5.1	7.4	1.6	2.7
Qualifications: O levels/GCSEs or equivalent	4.6	7.4	10.9	-2.0	-3.3
Maternal smoking around birth	4.5	6.6	8.6	-2.9	-2.1
Trunk fat mass	4.5	19.3	32.7	5.7	2.4
Arm fat mass (right)	4.5	18.5	28.0	5.3	3.0
LDL Cholesterol	4.4	7.0	7.4	-2.7	-2.5
Heel bone mineral density (BMD) T-score, automated (left)	4.4	9.9	15.6	2.1	4.0
Heel bone mineral density (BMD) T-score, automated (right)	4.3	9.9	16.1	1.9	4.0
Hayfever/allergic rhinitis (self-reported)	4.2	5.6	5.9	-2.4	-2.3
Arm fat mass (left)	4.1	16.8	25.6	5.1	2.8
Eye problems/disorders: Glaucoma	4.1	4.9	5.9	2.4	2.0
Prostate Cancer	4.0	5.7	6.9	-2.6	-2.1
Noisy workplace	3.9	4.9	6.7	2.6	1.7
Mouth/teeth dental problems: Loose teeth	3.9	4.6	6.5	-2.6	-1.6
Illness, injury, bereavement, stress in last 2 years	3.7	4.5	6.6	2.6	1.6
Diabetes (self-reported)	3.6	5.6	8.2	-2.9	-1.7
Ulcerative Colitis (UC)	3.5	6.6	9.7	3.1	1.9
Body mass index (BMI)	3.5	14.7	19.2	4.4	3.2
Waist circumference	3.3	12.1	17.6	4.2	2.6
Lung FEV1/FVC ratio	3.2	16.1	24.1	4.9	2.8
Serious illness, injury or assault of a close relative in last 2 years	3.2	3.7	5.3	-2.3	-1.4
Pulse wave reflection index	3.2	3.9	4.0	-1.9	-2.0
Chronic bronchitis/emphysema (mother)	2.9	3.3	4.3	-1.5	-2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.9	3.5	4.8	-2.2	-1.5
Alzheimer’s Disease (in mother)	2.8	3.3	4.2	-1.5	-2.1
Pulse rate	2.8	4.8	4.9	2.2	2.1
Medication: Gliclazide	2.8	3.2	5.2	-2.3	-1.1
Blood Platelet Count	2.6	29.9	30.4	5.4	5.5
Mood swings	2.6	4.8	6.7	2.6	1.7
Lung FVC	2.5	12.9	16.6	-4.1	-3.0
Ever highly irritable/argumentative for 2 days	2.5	3.0	4.4	1.3	2.1
Diabetes diagnosed by doctor	2.4	3.9	5.0	-2.2	-1.7
Breast cancer (self-reported)	2.4	2.8	4.3	-2.1	-1.2
Blood Red Count	2.2	21.6	32.5	3.3	5.7
Systolic blood pressure, automated reading	2.2	6.4	7.8	2.2	2.8
Sitting height	2.2	15.9	26.9	-2.2	-5.2
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.5	3.4	1.3	1.9
Systolic Blood Pressure	2.1	10.6	14.9	2.5	3.9
Hand grip strength (left)	2.1	5.5	6.6	2.6	2.1
Ever unenthusiastic/disinterested for a whole week	2.1	2.5	3.8	2.0	1.1
Hearing difficulty/problems with background noise	2.0	3.2	3.8	1.6	2.0
Weight	2.0	9.9	17.0	4.1	1.7
Qualifications: A levels/AS levels or equivalent	2.0	4.4	6.8	-1.4	-2.6
Hip circumference	1.9	8.1	12.9	3.6	1.8
Alcohol intake versus 10 years previously	1.9	2.8	4.2	1.2	2.1
Pulse rate, automated reading	1.9	6.1	7.2	2.2	2.7
Illnesses of father: None of the above (group 1)	1.9	2.4	3.8	1.9	1.0
Type 2 Diabetes (T2D) (2012)	1.8	2.1	2.9	-1.7	-1.1
Tense / ‘highly strung’	1.8	3.1	4.3	2.1	1.4
Pack years of smoking	1.8	2.6	3.2	1.8	1.4
Mouth/teeth dental problems: Dentures	1.7	2.8	3.5	-1.5	-1.9
Bipolar Disorder (2018)	1.6	2.5	3.7	1.9	1.2
Peak expiratory flow (PEF)	1.6	3.7	5.1	2.3	1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	2.1	1.2	1.5
Average weekly beer plus cider intake	1.6	2.3	2.7	-1.6	-1.4
Major Depression (MDD)	1.5	1.8	2.4	1.6	1.1
Type 2 Diabetes (T2D) (2018)	1.5	2.8	3.2	-1.8	-1.5
Hand grip strength (right)	1.5	4.1	4.5	1.9	2.1
Falls in the last year	1.5	2.1	3.1	1.8	1.0
Number of live births	1.5	2.1	3.1	-1.8	-1.0
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	3.4	1.2	1.9
Depressed Affect (Nagel 2018)	1.4	3.0	4.7	2.2	1.2
Ulcerative Colitis	1.4	2.1	3.3	1.8	0.9
Allergy or Eczema	1.4	3.6	4.0	-2.0	-1.8
Respiratory disease	1.4	3.0	4.8	-2.2	-1.1
Number of treatments/medications taken	1.4	2.4	3.3	-1.2	-1.8
Pack years adult smoking proportion	1.4	2.1	2.7	1.6	1.2
Forced vital capacity (FVC)	1.4	5.5	6.1	-2.2	-2.5
Number of full brothers	1.4	1.8	2.1	-1.4	-1.2
Ever had bowel cancer screening	1.4	1.6	2.6	-1.6	-0.8
Ever taken oral contraceptive pill	1.4	1.6	1.7	-1.3	-1.2
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	2.0	1.4	1.3
Had menopause	1.3	1.6	3.1	-0.5	-1.8
Had other major operations	1.3	1.6	1.8	-1.3	-1.2
Headache pain in last month	1.3	2.2	3.8	0.7	1.9
Glaucoma (self-reported)	1.3	1.5	1.6	1.2	1.2
Qualifications: College or University degree	1.3	4.2	5.7	-2.4	-1.6
Height	1.2	23.0	37.6	-2.9	-6.1
Diabetes (mother)	1.2	1.6	2.9	0.5	1.7
Current tobacco smoking	1.2	2.0	2.6	-1.2	-1.6
Qualifications: None of the above	1.2	2.5	2.9	1.7	1.4
Medication: Paracetamol	1.2	2.0	3.2	-1.8	0.9
Medication: Aspirin	1.2	1.5	2.6	0.7	1.6
Number of self-reported non-cancer illnesses	1.2	2.1	3.1	-1.8	-1.0
Leg fat-free mass (left)	1.1	5.7	9.9	3.1	1.2
Leg predicted mass (left)	1.1	5.6	9.8	3.1	1.2
Osteoporosis (self-reported)	1.1	1.4	2.0	-0.8	-1.4
Mother’s age at death	1.1	1.4	1.9	-1.4	-0.9
Diastolic blood pressure, automated reading	1.1	3.4	5.0	1.3	2.2
Irritable Bowel Disease (IBD)	1.0	2.3	3.8	1.9	0.9
Hearing difficulty/problems: Yes	1.0	1.5	1.6	1.3	1.1
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	1.5	1.2	1.0
Chronic bronchitis/emphysema (father)	1.0	1.2	1.7	-1.3	-0.8
Depression (self-reported)	1.0	1.3	1.5	-1.2	-1.0
Smoking status: Current	1.0	1.5	2.0	-1.0	-1.4
Age at First Birth	0.9	1.3	1.5	-1.1	-1.2
Prospective memory result	0.9	1.1	1.7	0.7	1.3
Long-standing illness, disability or infirmity	0.9	1.3	2.2	-0.6	-1.5
Medication: Blood pressure	0.9	1.8	2.7	-0.9	-1.6
Alcohol drinker status: Never	0.9	1.1	1.4	1.2	0.9
Ever had prostate specific antigen (PSA) test	0.9	1.1	1.9	0.5	1.4
Myopia	0.9	1.2	2.5	-0.2	1.6
Basal cell carcinoma (self-reported)	0.9	1.1	2.0	-0.4	1.4
Medication for hormone replacement therapy	0.8	0.9	1.0	0.9	1.0
Pulse wave Arterial Stiffness index	0.8	0.9	1.6	-0.4	-1.3
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	1.5	-1.2	-0.8
Blood clot in the leg (DVT)	0.8	1.1	1.3	1.1	0.9
Forced vital capacity (FVC), Best measure	0.8	2.8	3.2	-1.6	-1.8
Shortness of breath walking on level ground	0.8	0.9	1.6	1.2	-0.5
Migraine (self-reported)	0.8	1.0	2.0	-1.4	-0.4
Illnesses of father: Heart disease	0.8	1.1	1.9	-0.6	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	3.0	-0.6	-1.7
Average weekly champagne plus white wine intake	0.8	1.1	1.2	1.0	1.1
Crohns Disease (2012)	0.7	1.1	1.2	-1.1	-1.0
Neuroticism (2016)	0.7	1.1	1.2	-1.0	-1.1
Medication: Levothyroxine sodium	0.7	1.2	2.1	-0.6	-1.4
Nervous feelings	0.7	1.2	2.1	1.4	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.2	1.0	1.1
Birth weight of first child	0.7	1.3	2.5	1.6	-0.0
High blood pressure (siblings)	0.7	1.1	2.2	0.0	1.5
Wheeze or whistling in the chest in last year	0.7	1.3	1.6	-1.3	-1.0
Health satisfaction	0.7	0.9	1.7	1.3	0.4
Family relationship satisfaction	0.7	0.9	1.6	-1.3	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	0.9	1.0	0.8
Leg fat-free mass (right)	0.7	3.5	6.4	2.5	0.8
Average weekly red wine intake	0.7	1.1	1.2	1.0	1.1
Asthma (self-reported)	0.7	1.4	2.6	-1.6	-0.4
Medication: Paracetamol	0.7	1.1	1.4	-1.2	0.9
Supplements: Calcium	0.7	0.7	1.1	-0.6	-1.0
Bipolar Disorder or Schizophrenia	0.6	1.5	2.9	1.7	0.1
Ovarian Cancer	0.6	0.8	1.6	-0.2	-1.3
HbA1C	0.6	0.7	0.8	-0.8	-0.9
Medication: Metformin	0.6	0.8	1.2	-1.1	-0.7
Serious illness, injury or assault to yourself	0.6	0.7	0.8	-0.8	-0.9
Mouth/teeth dental problems	0.6	0.9	1.0	1.0	0.9
Hair/balding pattern: Pattern 3	0.6	0.9	1.6	-0.4	-1.3
Asthma	0.6	1.2	2.2	-1.5	-0.4
Hair/balding pattern: Pattern 4	0.6	1.4	2.5	-0.5	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	0.8	0.9	0.8
Number of full sisters	0.6	0.7	0.9	1.0	0.7
Leg predicted mass (right)	0.6	3.4	6.2	2.5	0.8
Miserableness	0.6	1.0	1.1	0.9	1.1
Basal metabolic rate	0.6	3.5	6.0	2.4	1.0
Blood White Count	0.5	3.7	6.1	1.2	2.5
Tanning	0.5	6.6	12.7	-0.7	-3.6
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.3	-1.1	-0.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.5	-0.7	-0.7
Townsend deprivation index at recruitment	0.5	0.7	1.0	-1.0	-0.7
Average weekly fortified wine intake	0.5	0.6	0.8	0.7	0.9
Taking other prescription medications	0.5	0.8	0.9	-0.8	-1.0
Hayfever, allergic rhinitis or eczema	0.5	1.0	1.4	-1.2	-0.8
Multivitamins +/- minerals	0.5	0.6	1.1	1.0	0.4
Father’s age at death	0.5	0.7	0.9	-0.9	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.0	1.0	0.7
Standing height	0.5	4.8	9.4	-0.4	-3.1
Pulse wave peak to peak time	0.5	0.6	1.0	0.5	1.0
Medication for pain relief, constipation, heartburn	0.5	0.9	1.5	0.6	-1.2
Comparative height size at age 10	0.5	2.8	5.5	2.4	0.2
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.0	1.0	0.5
Wears glasses or contact lenses	0.5	0.6	1.1	-1.0	-0.3
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.0	1.0	0.5
Medication: Bendroflumethiazide	0.5	0.7	1.3	0.3	-1.1
Irritability	0.5	0.8	1.6	0.0	1.3
Alzheimer’s Disease (in father)	0.4	0.4	0.9	-0.9	0.1
Alzheimer’s Disease (including proxy)	0.4	0.6	1.0	-1.0	-0.5
Mean Putamen Volume	0.4	0.5	0.8	-0.3	-0.9
Waist Hip Ratio (WHR)	0.4	1.8	2.2	1.5	1.2
Cardiovascular Disease	0.4	1.3	2.1	0.7	1.5
Vitamin and mineral supplements	0.4	0.5	0.8	-0.9	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	0.8	0.9	0.6
Relative age voice broke	0.4	0.6	1.0	1.0	0.6
Supplements: Glucosamine	0.4	0.5	0.8	0.9	0.5
Alcohol usually taken with meals	0.4	0.7	0.9	1.0	0.6
Neuroticism score	0.4	0.8	1.0	0.8	1.0
Impedance of arm (right)	0.4	1.7	2.3	1.5	-1.0
Impedance of arm (left)	0.4	1.7	2.0	1.2	-1.4
Length of working week for main job	0.4	0.4	0.6	-0.5	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.1	0.4	1.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.6	-0.2	-1.3
Eye problems/disorders: None of the above	0.4	0.4	0.5	0.7	0.6
Age at last live birth	0.4	0.6	0.8	0.6	0.9
Medication: Aspirin	0.4	0.5	1.1	0.1	1.0
Financial situation satisfaction	0.4	0.5	0.5	-0.7	-0.7
Commuting to job workplace: Public transport	0.4	0.5	0.5	-0.6	0.7
Risk taking	0.4	0.5	0.9	-0.9	-0.4
Schizophrenia (2018)	0.3	0.6	0.7	0.7	-0.8
Worry (Nagel 2018)	0.3	0.7	0.7	0.8	0.8
Crohns Disease (2017)	0.3	0.7	0.9	-0.6	-1.0
Schizophrenia (2014)	0.3	0.6	1.1	1.1	0.1
Triglycerides	0.3	0.5	1.0	-1.0	0.1
Hypothyroidism (self reported)	0.3	0.8	1.0	0.8	-1.0
Relative age of first facial hair	0.3	0.7	1.3	-0.3	-1.1
Ever had hysterectomy (womb removed)	0.3	0.4	0.7	0.8	-0.2
Supplements: Zinc	0.3	0.3	0.4	0.5	0.7
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.6	-0.8	-0.1
Qualifications: CSEs or equivalent	0.3	0.5	0.6	-0.8	-0.5
Financial difficulties in last 2 years	0.3	0.4	0.6	-0.7	-0.6
Allergy	0.3	0.7	1.3	1.2	0.4
Medication: Ramipril	0.3	0.4	0.7	0.8	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.7	-0.2	0.8
Medication: Lansoprazole	0.3	0.4	0.6	0.8	-0.4
Illnesses of mother	0.3	0.4	0.6	-0.3	-0.8
Gout (self-reported)	0.3	0.4	0.7	-0.8	0.1
Birth weight	0.3	0.6	1.1	1.0	-0.4
Number of children fathered	0.3	0.3	0.4	-0.6	0.5
Medication: Allopurinol	0.3	0.4	0.6	-0.7	0.5
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.4	-0.4	-0.6
Whole body fat-free mass	0.3	1.5	2.6	1.6	0.6
Eye problems/disorders: Cataract	0.3	0.4	0.5	-0.5	0.7
Back pain experienced in last month	0.3	0.4	0.7	-0.8	-0.2
Whole body water mass	0.3	1.5	2.6	1.6	0.6
High cholesterol (Self-reported)	0.3	0.5	0.9	-0.9	-0.3
Fractured/broken bones in last 5 years	0.3	0.4	0.5	0.6	0.7
Unable to work because of sickness or disability	0.3	0.4	0.6	-0.3	-0.8
Commuting to job workplace: Cycle	0.3	0.3	0.5	0.7	-0.3
Alcohol drinker status: Previous	0.3	0.3	0.4	0.7	-0.4
Impedance of whole body	0.3	1.3	2.1	0.7	-1.4
Depression (Nagel 2018)	0.2	0.3	0.4	0.6	0.5
Neuroticism (Nagel 2018)	0.2	0.4	0.6	0.8	0.5
Schizophrenia vs Biploar Disorder	0.2	0.3	0.5	0.4	0.7
Body Mass Index (BMI) (2010)	0.2	0.2	0.4	0.6	0.3
Fasting Glucose	0.2	0.2	0.3	0.5	0.3
Lupus	0.2	0.3	0.6	-0.8	0.2
Chronotype (morning person)	0.2	0.4	0.7	0.8	-0.3
Fed-up feelings	0.2	0.4	0.5	0.5	0.7
Medication: Atenolol	0.2	0.2	0.4	0.1	-0.7
Hair/balding pattern: Pattern 2	0.2	0.2	0.4	0.0	-0.6
Pain all over the body in last month	0.2	0.2	0.4	-0.6	-0.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.2	-0.4	-1.1
Happiness	0.2	0.2	0.4	-0.6	-0.0
Medication: Cholesterol lowering	0.2	0.2	0.4	-0.6	-0.2
Arm fat-free mass (right)	0.2	1.1	1.8	1.3	0.6
Worry too long after embarrassment	0.2	0.4	0.7	-0.2	-0.8
Medication: Ibuprofen	0.2	0.2	0.2	-0.5	0.5
Arm predicted mass (right)	0.2	1.2	1.9	1.4	0.7
Alcohol intake frequency.	0.2	0.5	0.5	0.7	0.7
Knee pain experienced in last month	0.2	0.2	0.4	0.6	0.3
Loneliness, isolation	0.2	0.3	0.6	0.3	0.7
Qualifications: nursing, teaching	0.2	0.3	0.3	-0.5	-0.5
Medication for cholesterol	0.2	0.3	0.5	-0.7	0.3
Arm fat-free mass (left)	0.2	0.8	1.5	1.2	0.5
Cholesterol lowering medication	0.2	0.2	0.4	-0.6	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	-0.2	-0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.5	-0.3	-0.7
Heart disease (siblings)	0.2	0.2	0.5	0.7	-0.1
Arm predicted mass (left)	0.2	1.1	1.8	1.3	0.7
Coronary Artery Disease (CAD)	0.1	0.2	0.3	0.6	0.1
HDL Cholesterol	0.1	0.2	0.3	0.5	-0.3
Rheumatoid Arthritis	0.1	0.2	0.3	-0.5	-0.2
Blood Eosinophil Count	0.1	0.7	1.0	-0.7	-1.0
Average weekly spirits intake	0.1	0.1	0.2	0.0	-0.5
Sensitivity / hurt feelings	0.1	0.1	0.2	0.3	0.4
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	0.1	0.5
Medication: Co-codamol	0.1	0.1	0.3	-0.1	-0.5
Severe depression (siblings)	0.1	0.1	0.1	0.1	-0.3
Impedance of leg (right)	0.1	0.3	0.3	0.5	-0.6
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.5	0.3
Impedance of leg (left)	0.1	0.4	0.7	0.2	-0.9
Heart attack	0.1	0.2	0.3	-0.2	-0.5
Medication: Simvastatin	0.1	0.1	0.3	-0.5	0.1
Illnesses of siblings	0.1	0.1	0.2	-0.1	-0.5
Time employed in main current job	0.1	0.1	0.2	0.2	0.5
Worrier / anxious feelings	0.1	0.3	0.4	0.3	0.6
Breastfed as a baby	0.1	0.1	0.2	-0.5	-0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	0.7	0.1
Exposure to tobacco smoke outside home	0.1	0.1	0.1	-0.0	-0.4
Comparative body size at age 10	0.1	0.2	0.2	-0.4	-0.4
Age at first live birth	0.1	0.1	0.1	0.4	-0.4
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.4	-0.2
Neck or shoulder pain in last month	0.1	0.2	0.2	-0.3	-0.5
Medication: Omeprazole	0.1	0.1	0.2	-0.1	-0.4
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.4	0.3
Heart disease (mother)	0.1	0.2	0.3	-0.6	0.0
Chest pain or discomfort	0.1	0.1	0.3	-0.5	0.1
Had major operations	0.1	0.2	0.2	-0.3	-0.5
Supplements: Vitamin C	0.1	0.1	0.1	-0.1	0.4
Commuting to job workplace: Walk	0.1	0.2	0.2	0.4	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.1	-0.3	-0.3
Osteoarthritis (self-reported)	0.1	0.2	0.3	-0.5	-0.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.1	-0.1	-0.3
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	-0.4	-0.4
Medication: Lisinopril	0.1	0.1	0.1	-0.3	0.3
Medication: Atorvastatin	0.1	0.1	0.2	0.5	0.2
Illnesses of father: High blood pressure	0.1	0.1	0.1	-0.4	0.0
Age started oral contraceptive pill	0.1	0.1	0.2	-0.5	-0.2
Ever depressed for a whole week	0.1	0.1	0.1	0.2	0.3
Pain experienced in last month	0.1	0.2	0.3	0.3	-0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Primary Biliary Cirrhosis	0.0	0.0	0.0	0.1	0.2
Neuroticism	0.0	0.1	0.1	0.0	0.3
Hair Pigment	0.0	0.5	1.1	0.1	-1.0
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.1	0.1	-0.3
Angina	0.0	0.0	0.0	-0.2	-0.2
High blood pressure	0.0	0.1	0.1	0.3	0.3
Stomach or abdominal pain in last month	0.0	0.0	0.0	-0.2	0.2
High blood pressure (mother)	0.0	0.0	0.0	0.1	0.1
Trunk fat-free mass	0.0	0.2	0.4	0.6	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.1	0.1	-0.3
Trunk predicted mass	0.0	0.2	0.5	0.7	0.1
Exposure to tobacco smoke at home	0.0	0.0	0.0	-0.2	0.0
Medication: Amlodipine	0.0	0.0	0.0	-0.1	-0.2
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.1	0.2	0.3
Medication: Blood pressure	0.0	0.0	0.1	-0.1	0.3
Angina (self-reported)	0.0	0.0	0.0	-0.0	0.0
Suffer from ‘nerves’	0.0	0.0	0.0	-0.0	-0.2
Overall health rating	0.0	0.1	0.2	0.0	-0.4
Leg pain on walking	0.0	0.0	0.0	0.1	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.0	0.1	0.1
Hypertension (Self-reported)	0.0	0.0	0.0	0.1	0.0
Illnesses of siblings: Diabetes	0.0	0.1	0.1	-0.1	0.3
Friendships satisfaction	0.0	0.0	0.0	-0.2	0.1
Mineral and other dietary supplements	0.0	0.0	0.0	0.0	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.0	0.0	0.1	0.1
Guilty feelings	0.0	0.0	0.0	-0.0	-0.0
Hearing aid user	0.0	0.0	0.0	-0.0	0.2
Number of operations (self-reported)	0.0	0.0	0.0	-0.1	-0.2
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.1	-0.4	-0.4

Hub : Genes

C22orf23

Models

Trait associations