TWAS hub - ANKRD54

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1410	0.0470	1.3e-03	0.020	NA	0.064	NA	0.038	8.7e-03	NA	5.9e-06	NA	4.4e-04
2	GTEx	Cells Transformed fibroblasts	0.1100	0.0400	5.1e-04	0.091	NA	0.065	NA	0.086	2.6e-07	NA	1.4e-05	NA	5.3e-07
3	GTEx	Muscle Skeletal	0.1451	0.0400	1.5e-05	0.017	NA	0.038	NA	0.035	7.9e-03	NA	1.1e-04	NA	2.2e-04
4	GTEx	Skin Sun Exposed Lower leg	0.0740	0.0280	6.9e-04	0.038	NA	0.043	NA	0.031	3.9e-04	NA	1.6e-04	NA	1.2e-03
5	ROSMAP	Brain Pre-frontal Cortex	0.0268	0.0136	7.2e-03	0.002	0.009	-0.002	0.008	-0.002	1.6e-01	2.2e-02	9.4e-01	0.032	9.4e-01
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.1970	0.0719	3.8e-04	0.062	0.048	0.053	NA	0.059	1.6e-07	3.6e-06	1.2e-06	NA	3.0e-07
7	TCGA	Brain Lower Grade Glioma	0.0495	0.0292	1.1e-03	0.008	0.022	0.009	NA	0.010	3.4e-02	1.3e-03	2.7e-02	NA	2.3e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Fluid intelligence score	7.5	15.5	23.8	3.5	4.4	4.1	3.3	3.1	4.1	4.9
Body fat percentage	7.2	28.3	37.7	-4.5	-5.9	-5.3	-5.4	-6.1	-5.7	-3.8
Arm fat percentage (left)	7.0	27.8	34.5	-5.0	-5.9	-5.6	-5.6	-5.6	-5.7	-2.9
Arm fat percentage (right)	6.8	26.7	33.1	-4.9	-5.8	-5.4	-5.5	-5.5	-5.5	-3.1
Trunk fat percentage	6.7	26.9	35.2	-4.3	-5.7	-5.4	-5.5	-5.9	-5.6	-3.3
Noisy workplace	6.3	7.8	10.6	-2.8	-2.9	-3.3	-3.1	-2.2	-3.0	-2.1
Leg fat percentage (right)	6.0	21.7	32.7	-3.6	-5.1	-4.0	-4.5	-5.7	-5.0	-4.3
Leg fat percentage (left)	5.8	20.8	27.2	-3.8	-5.2	-4.2	-4.3	-5.1	-5.1	-3.9
Intelligence (Savage-Jansen 2018)	5.6	17.1	31.0	1.6	4.4	3.5	3.3	4.8	4.5	5.6
Medication: Ibuprofen	5.6	6.7	13.1	2.9	2.8	3.6	2.9	0.5	2.5	-1.5
Whole body fat mass	5.6	23.4	30.4	-4.1	-5.3	-4.8	-5.1	-5.5	-5.4	-3.3
Medication: Ibuprofen (e.g. Nurofen)	5.3	6.7	14.0	2.7	2.9	3.7	3.0	0.4	2.6	-1.0
Leg fat mass (right)	5.3	20.6	29.8	-3.5	-4.9	-3.9	-4.6	-5.5	-5.2	-3.8
Verbal and Numeric Reasoning (VNR)	5.2	12.6	23.3	2.2	3.7	3.5	3.0	3.5	3.6	4.8
Leg fat mass (left)	5.2	20.3	28.2	-3.7	-5.0	-4.1	-4.5	-5.1	-5.3	-3.6
BMI	5.0	28.8	31.7	-5.6	-5.6	-5.5	-5.5	-5.5	-4.9	-4.9
Trunk fat mass	5.0	21.5	28.6	-3.8	-5.1	-4.6	-5.0	-5.3	-5.4	-2.8
Arm fat mass (right)	4.9	20.2	25.7	-4.2	-4.9	-4.5	-4.8	-4.7	-5.1	-2.7
Loud music exposure frequency	4.9	5.4	8.6	-2.9	-2.5	-2.7	-2.3	-2.1	-2.3	-0.3
Arm fat mass (left)	4.7	19.3	24.4	-4.1	-4.9	-4.6	-4.7	-4.5	-4.9	-2.6
Body mass index (BMI)	4.5	19.3	23.5	-4.8	-4.8	-4.6	-4.5	-4.0	-4.8	-2.6
Waist circumference	3.9	14.4	17.0	-3.5	-4.1	-3.7	-4.1	-4.0	-4.1	-2.9
Reaction Time	3.8	7.3	18.2	2.0	2.5	2.5	2.7	4.3	1.9	2.3
Mean time to correctly identify matches	3.8	7.2	17.9	1.5	2.3	1.8	2.8	4.2	2.3	2.9
Eye problems/disorders: Glaucoma	3.8	4.4	11.2	-1.4	-1.9	-0.8	-1.3	-2.9	-2.0	-3.4
Breast Cancer	3.3	7.9	24.0	-0.8	-2.0	-2.3	-2.7	-4.9	-1.1	-3.7
Ever unenthusiastic/disinterested for a whole week	3.2	3.9	6.3	-1.4	-2.3	-2.1	-2.5	-1.7	-2.2	-1.5
Medication: Lansoprazole	3.2	3.6	6.2	-2.5	-2.3	-2.2	-2.0	-0.5	-2.0	-0.3
Lung cancer (father)	2.9	3.4	7.5	1.0	1.9	0.9	2.0	2.7	1.8	1.9
Pack years adult smoking proportion	2.8	4.3	7.3	-2.1	-2.5	-2.7	-2.7	-1.3	-1.8	-0.2
Prospective memory result	2.7	3.3	7.5	-1.2	-2.0	-1.3	-1.1	-1.3	-2.7	-2.4
Qualifications: O levels/GCSEs or equivalent	2.7	4.4	10.6	0.0	1.9	0.7	1.0	3.2	2.6	2.8
Exposure to tobacco smoke outside home	2.7	3.6	6.9	-2.3	-2.5	-2.1	-1.2	0.2	-2.6	0.6
Pack years of smoking	2.7	4.0	6.9	-1.9	-2.4	-2.5	-2.6	-1.7	-1.6	-0.5
Falls in the last year	2.5	3.4	7.8	-2.8	-1.5	-2.3	-2.0	-1.2	-1.7	-0.3
Ever highly irritable/argumentative for 2 days	2.4	2.9	5.2	-1.0	-1.3	-2.2	-1.9	-1.9	-0.8	-2.3
Number of incorrect matches in round	2.3	3.8	7.3	-1.6	-1.7	-1.3	-2.2	-2.2	-1.7	-2.7
Illness, injury, bereavement, stress in last 2 years	2.3	2.8	6.9	-0.9	-1.7	-2.0	-1.2	-2.6	-1.4	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	2.3	4.7	7.8	2.8	2.6	2.7	1.9	1.7	2.0	0.7
Heel bone mineral density (BMD) T-score, automated (left)	2.2	4.9	13.2	-0.8	-1.7	-0.5	-1.9	-2.9	-2.4	-3.6
Hip circumference	2.2	9.6	15.1	-3.0	-3.3	-3.1	-3.3	-3.3	-3.9	-1.0
Glaucoma (self-reported)	2.2	2.6	6.2	-1.1	-1.5	-0.1	-0.6	-2.1	-1.9	-2.5
Mouth/teeth dental problems: Loose teeth	2.2	2.6	7.0	0.9	1.6	1.1	1.4	2.6	1.5	1.5
Age when periods started (menarche)	2.1	4.9	7.4	2.0	2.4	2.3	2.7	2.7	1.9	1.3
Weight	2.1	10.1	14.5	-3.0	-3.4	-3.2	-3.5	-3.2	-3.8	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.5	11.1	-1.2	-1.7	-0.4	-1.9	-2.5	-2.4	-3.3
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	6.1	-1.0	-1.8	-1.4	-2.0	-1.3	-1.9	-2.5
Prostate Cancer	1.8	2.5	6.6	1.0	1.6	0.8	1.3	2.1	0.6	2.6
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	3.3	1.8	1.2	1.8	1.8	1.7	1.4	0.5
Qualifications: College or University degree	1.8	5.8	9.8	1.2	3.0	2.3	2.7	2.3	3.1	1.5
Migraine (self-reported)	1.8	2.2	3.9	2.0	1.6	1.9	1.5	0.4	1.4	1.1
Alcohol drinker status: Previous	1.8	2.0	4.2	-1.7	-1.6	-2.1	-1.9	-0.4	-0.4	-0.5
Heel T-Score	1.7	13.4	47.2	0.1	-2.0	-0.3	-1.9	-5.9	-2.1	-6.9
Hand grip strength (left)	1.7	4.4	10.9	2.9	1.1	2.6	0.7	-1.8	0.2	-3.3
High blood pressure (mother)	1.7	2.3	5.3	2.3	1.9	1.1	0.9	0.6	1.9	-1.3
Past tobacco smoking	1.7	3.1	14.8	-0.0	-0.6	-0.4	-1.5	-3.8	-0.2	-1.9
Pulse wave reflection index	1.7	2.1	7.7	-0.7	0.5	-0.2	0.7	2.3	0.1	2.8
Knee pain experienced in last month	1.7	2.7	5.9	-1.7	-1.6	-1.7	-1.2	0.0	-2.4	-1.9
Systolic Blood Pressure	1.6	7.8	28.1	3.1	0.0	1.3	0.4	-3.9	0.4	-5.3
Smoking Status	1.6	3.8	15.8	0.6	0.2	0.4	1.4	4.0	0.0	2.9
Respiratory disease	1.6	3.5	6.1	0.6	2.3	2.5	2.0	2.2	2.0	0.4
Breastfed as a baby	1.6	2.0	3.9	0.8	2.0	1.5	1.8	0.7	1.9	0.1
Alcohol intake frequency.	1.6	3.7	6.7	-2.6	-1.6	-2.2	-2.2	-1.3	-1.0	-2.1
Ever had prostate specific antigen (PSA) test	1.6	1.9	4.8	2.2	1.0	1.3	1.0	-1.2	1.1	-1.4
LDL Cholesterol	1.5	2.4	6.2	0.6	1.7	0.7	1.2	2.5	1.8	1.5
Systolic blood pressure, automated reading	1.5	4.4	14.4	2.2	-0.2	0.8	0.3	-3.2	-0.3	-3.8
Townsend deprivation index at recruitment	1.5	2.1	3.4	-1.6	-1.9	-1.7	-1.1	0.3	-1.5	1.5
Maternal smoking around birth	1.5	2.1	6.1	0.2	0.5	-0.5	1.4	2.5	0.6	2.4
Tense / ‘highly strung’	1.5	2.6	7.8	0.3	-1.2	-0.7	-1.1	-2.1	-1.6	-2.8
Overall health rating	1.5	3.2	4.7	-1.7	-1.8	-1.9	-2.2	-0.7	-2.0	-1.8
Mood swings	1.5	2.8	5.3	-0.7	-1.7	-0.9	-2.0	-2.2	-1.2	-2.3
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	3.9	-0.0	-1.5	-0.8	-1.5	-1.6	-2.0	-0.2
Average weekly beer plus cider intake	1.5	2.2	4.7	-1.3	-0.9	-1.3	-1.1	2.0	-1.0	2.2
Deep venous thrombosis (DVT) (self-reported)	1.5	2.0	3.9	-0.4	-1.6	-1.0	-1.1	-1.7	-2.0	-1.3
Hand grip strength (right)	1.4	3.7	8.6	2.9	1.2	2.6	0.6	-2.0	0.4	-2.1
Qualifications: None of the above	1.4	3.1	6.8	-0.6	-2.3	-1.5	-1.6	-1.5	-2.6	-1.4
Alcohol intake versus 10 years previously	1.4	2.1	5.4	-2.3	-1.2	-1.4	-2.0	-1.3	-0.4	-0.6
Blood clot in the leg (DVT)	1.4	1.8	4.3	-0.2	-1.6	-0.8	-1.0	-1.5	-2.1	-1.3
Number of full sisters	1.4	1.7	2.7	-1.4	-1.5	-1.4	-1.6	-1.3	-0.8	-0.4
Breast cancer (self-reported)	1.4	1.6	2.8	-1.2	-1.7	-0.9	-0.7	1.6	-1.7	0.8
Alcohol drinker status: Never	1.4	1.7	4.8	-1.6	-0.9	-1.2	-0.7	-1.0	-0.9	-2.2
Unable to work because of sickness or disability	1.4	1.8	3.1	-1.7	-1.8	-1.6	-1.5	0.4	-0.9	0.9
Ulcerative Colitis (UC)	1.3	2.5	7.7	-0.7	-0.7	-0.5	-1.3	-2.6	0.0	-2.8
Ovarian Cancer	1.2	1.6	6.2	2.5	0.7	1.7	0.7	0.9	0.2	-0.8
Ulcerative Colitis	1.2	1.8	4.6	-1.1	-0.7	-0.9	-2.1	-1.4	-0.2	-1.8
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	3.4	-0.4	-1.0	-0.9	-1.4	-1.8	-1.4	-0.6
Forced vital capacity (FVC)	1.2	4.6	10.9	1.8	1.9	1.9	1.5	2.6	1.3	3.3
Happiness	1.2	1.5	8.9	0.6	0.6	-0.3	-0.0	-0.3	0.7	-3.0
Birth weight of first child	1.2	2.1	3.9	-0.9	-1.6	-2.0	-1.8	-1.1	-1.8	-0.3
High blood pressure (siblings)	1.2	1.8	4.6	-0.6	-1.3	-0.8	-2.1	-1.0	-2.1	-0.3
Forced vital capacity (FVC), Best measure	1.2	4.3	9.3	2.0	1.9	2.0	1.7	2.0	1.6	3.1
Number of full brothers	1.2	1.5	7.1	-1.3	-0.0	-0.5	0.0	1.0	0.6	2.7
Medication: Bendroflumethiazide	1.2	1.8	4.5	2.1	1.5	1.6	1.1	0.1	0.7	-1.4
Ever smoked	1.2	2.0	10.9	-0.1	0.0	0.1	0.9	3.3	-0.1	1.6
Irritability	1.2	2.1	5.0	-0.8	-1.6	-1.9	-0.9	-1.2	-2.2	-0.5
Lupus	1.1	1.7	4.7	-1.1	-1.9	-1.2	-0.8	0.3	-2.2	0.6
Leg fat-free mass (left)	1.1	5.7	10.2	-2.3	-2.5	-2.5	-2.9	-2.0	-3.2	-0.1
Sitting height	1.1	7.5	13.9	2.5	2.7	1.8	2.0	3.5	2.4	3.7
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	6.4	2.5	1.8	2.4	1.7	1.4	1.1	1.9
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	3.0	0.6	1.4	1.7	0.9	1.6	0.4	0.2
Smoking status: Previous	1.1	1.7	8.6	0.3	0.6	0.7	1.5	2.9	0.1	0.2
Friendships satisfaction	1.1	1.4	4.3	-0.8	1.2	0.4	-0.1	-0.1	1.8	-2.1
Mother’s age at death	1.1	1.4	3.0	0.7	1.3	1.5	1.7	1.1	1.2	-0.2
Myopia	1.1	1.5	3.1	1.2	1.7	1.8	1.4	-0.1	1.1	0.3
Fasting Glucose	1.0	1.2	2.9	-1.3	-1.7	-0.1	-1.1	-0.3	-1.6	0.0
Current tobacco smoking	1.0	1.6	5.4	1.0	0.2	0.8	0.6	1.7	0.8	2.3
Leg predicted mass (left)	1.0	5.3	9.7	-2.1	-2.4	-2.4	-2.8	-2.0	-3.1	-0.2
Had menopause	1.0	1.2	4.3	-1.4	-0.9	-2.1	-0.9	0.3	-0.6	-0.3
Pulse rate	1.0	1.6	5.5	0.4	-1.1	0.8	-0.1	-1.8	-0.8	-2.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	6.4	2.5	1.7	2.3	1.8	0.7	1.1	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.3	-0.4	-1.5	-0.9	-0.7	-1.3	-1.3	-1.3
Shortness of breath walking on level ground	1.0	1.1	2.5	-0.8	-1.3	-1.0	-0.6	-1.0	-1.6	-0.9
Leg pain on walking	1.0	1.2	2.7	-1.0	-1.2	-1.0	-1.2	-0.4	-1.7	-0.6
Medication: Atorvastatin	1.0	1.2	2.7	-1.6	-0.9	-0.9	-1.4	0.5	-0.7	1.1
Worry (Nagel 2018)	0.9	1.9	6.8	-0.1	-1.3	-0.7	-1.1	-1.6	-0.8	-2.6
Mean Putamen Volume	0.9	1.0	2.8	-1.0	-0.9	-0.8	-0.5	0.5	-1.2	1.7
Lung FEV1/FVC ratio	0.9	4.4	14.3	1.9	-0.0	0.8	0.1	-3.5	-0.4	-3.8
Medication: Metformin	0.9	1.2	3.0	-1.7	-0.7	-0.9	-1.0	1.3	-0.6	1.1
Impedance of leg (right)	0.9	4.1	9.3	3.0	1.6	2.3	1.4	-1.0	2.1	-2.1
Chronic bronchitis/emphysema (father)	0.9	1.0	1.7	0.8	1.1	0.9	1.1	1.1	1.3	0.7
Impedance of leg (left)	0.9	4.1	8.8	3.0	1.7	2.4	1.8	-0.4	2.2	-1.8
Alcohol usually taken with meals	0.9	1.4	2.3	1.2	1.5	1.5	1.4	-1.5	0.4	-0.2
Mouth/teeth dental problems	0.9	1.3	2.8	-1.7	-0.9	-0.9	-1.5	-1.3	-0.2	-0.7
Depression (self-reported)	0.9	1.0	2.0	-1.1	-1.4	-0.8	-0.8	1.4	-0.9	0.1
Exposure to tobacco smoke at home	0.9	1.0	1.7	1.3	1.0	1.1	1.3	0.2	1.0	-0.4
Peak expiratory flow (PEF)	0.9	2.1	6.0	2.5	0.8	2.3	0.8	-1.3	0.1	-0.4
Medication: Amlodipine	0.9	1.3	5.7	1.3	0.5	0.6	0.6	-0.6	0.1	-2.4
Chronic bronchitis/emphysema (mother)	0.9	1.1	3.2	-1.0	0.5	-0.4	0.5	1.6	0.5	1.8
Commuting to job workplace: Public transport	0.9	1.1	4.0	-1.3	-0.8	-0.7	-0.6	-0.5	-0.3	2.0
Cholesterol lowering medication	0.9	1.4	2.4	-0.8	-1.5	-1.4	-1.5	0.4	-0.7	1.4
Depressed Affect (Nagel 2018)	0.8	1.6	5.9	0.3	-0.8	-0.5	-0.6	-1.9	-0.4	-2.4
Age at First Birth	0.8	1.2	2.3	0.6	1.1	1.0	1.5	1.2	0.9	1.1
Body Mass Index (BMI) (2010)	0.8	1.0	2.0	-0.3	-1.4	-0.5	-0.9	-1.4	-1.4	0.4
Blood Platelet Count	0.8	8.7	26.4	-0.6	-3.0	-2.2	-3.0	-5.1	-3.3	0.8
Lung FVC	0.8	4.2	13.3	0.6	0.5	1.0	1.7	3.4	0.5	3.6
Diabetes (father)	0.8	1.0	2.3	0.6	1.1	0.7	0.1	1.5	0.6	1.5
Nervous feelings	0.8	1.5	7.4	0.5	-0.3	-0.1	-0.6	-1.4	0.3	-2.7
Hearing difficulty/problems with background noise	0.8	1.3	3.1	-0.9	-0.4	-1.3	-1.8	-1.0	-0.6	1.4
Pain all over the body in last month	0.8	0.9	1.8	-1.2	-0.8	-0.7	-1.3	-0.4	-1.3	0.3
Diabetes (self-reported)	0.8	1.2	4.8	-0.6	0.4	-0.2	0.3	2.2	1.0	1.3
Illnesses of siblings	0.8	1.2	3.5	0.3	1.2	0.3	1.8	0.4	1.9	-0.1
Qualifications: A levels/AS levels or equivalent	0.8	1.8	4.4	0.1	1.6	0.4	0.6	2.1	2.0	1.0
Number of children fathered	0.8	0.9	2.0	1.4	0.9	1.1	1.1	-0.2	0.5	0.9
Leg fat-free mass (right)	0.8	4.0	7.9	-2.2	-2.0	-2.1	-2.3	-1.3	-2.8	0.5
Average weekly champagne plus white wine intake	0.8	1.2	2.7	1.3	1.2	0.8	1.6	-1.1	0.6	0.3
Schizophrenia vs Biploar Disorder	0.7	0.9	2.6	-0.6	-0.7	-0.8	-1.2	-1.0	0.0	-1.6
Rheumatoid Arthritis	0.7	1.0	2.7	-0.2	-1.4	-0.9	-1.1	0.1	-1.7	0.3
Waist Hip Ratio (WHR)	0.7	3.2	17.7	0.1	-0.7	-0.2	-1.4	-1.5	0.3	-4.2
Hypothyroidism (self reported)	0.7	1.7	9.0	-0.1	-0.8	-0.9	-0.6	-0.4	-1.0	-3.0
Number of treatments/medications taken	0.7	1.2	5.0	1.3	0.3	0.5	0.6	1.0	-0.2	-2.2
Relative age of first facial hair	0.7	1.5	7.1	-1.1	-0.0	-1.1	-0.9	0.5	-0.0	2.7
Supplements: Glucosamine	0.7	0.9	4.1	-0.4	-0.7	-0.7	0.1	-0.9	-0.2	-2.0
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	2.1	1.0	1.0	0.8	1.0	1.4	0.2	0.8
Length of working week for main job	0.7	0.8	4.8	0.4	-0.1	-0.0	0.6	0.5	0.2	2.2
Wheeze or whistling in the chest in last year	0.7	1.2	3.7	-1.4	-0.4	-1.3	0.1	1.9	-0.2	0.9
Smoking status: Current	0.7	1.1	5.0	0.8	-0.0	0.3	0.2	1.4	0.5	2.2
Leg predicted mass (right)	0.7	3.7	7.4	-2.1	-1.9	-2.0	-2.2	-1.2	-2.7	0.5
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.2	0.8	1.0	1.0	1.0	0.9	0.9	-1.1
Risk taking	0.7	1.1	3.8	-0.4	0.7	-0.2	0.3	1.1	1.3	1.9
Diastolic blood pressure, automated reading	0.7	2.3	5.3	1.8	0.6	1.8	0.8	-1.8	0.2	-2.3
Heart attack/myocardial infarction (self-reported)	0.7	0.8	1.9	-0.7	1.0	-0.2	0.6	1.1	0.9	1.4
Height	0.6	11.7	24.4	3.1	3.6	2.6	2.1	4.4	2.1	4.9
Cardiovascular Disease	0.6	2.0	6.1	1.9	0.9	1.0	0.5	-1.0	1.2	-2.5
Severe depression (siblings)	0.6	0.6	3.0	-0.1	-0.1	0.2	0.0	0.3	1.1	1.7
Father’s age at death	0.6	0.8	2.0	1.0	1.0	1.1	0.7	0.4	1.4	0.3
Standing height	0.6	5.7	12.3	3.5	2.8	2.8	1.9	1.5	1.6	1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.8	2.6	1.6	-0.6	0.8	0.3	-1.1	-0.5	-0.5
Emphysema/chronic bronchitis	0.6	0.7	2.7	0.2	1.2	0.4	0.8	-0.1	1.6	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.6	-1.1	-0.6	-0.8	-1.3	-0.2	-0.5	-1.1
Commuting to job workplace: Car/motor vehicle	0.6	0.6	1.4	-0.0	1.0	1.0	0.5	1.2	0.9	0.1
Medication: Aspirin	0.6	0.8	2.0	-1.4	-0.6	-0.5	-1.3	-0.3	-1.0	-0.2
Average weekly red wine intake	0.6	0.9	2.6	1.2	0.1	0.8	0.6	-1.6	-0.5	-0.9
Loneliness, isolation	0.6	0.9	4.1	-0.1	-0.2	-0.8	-0.1	-1.1	-0.3	-2.0
Diabetes diagnosed by doctor	0.6	1.0	4.1	-1.1	-0.0	-0.5	-0.5	2.0	0.4	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.3	0.1	-1.2	-0.4	-0.8	-0.3	-1.5	-0.2
Asthma (self-reported)	0.6	1.2	3.4	-0.6	0.9	1.5	0.8	1.8	0.5	0.7
Osteoarthritis (self-reported)	0.6	0.7	2.3	0.7	0.3	0.9	0.9	0.1	-0.8	-1.5
Illnesses of father: None of the above (group 1)	0.6	0.7	2.6	-0.3	-0.8	-1.0	-0.3	-0.8	0.2	-1.6
Ever taken oral contraceptive pill	0.6	0.7	2.5	-0.6	0.4	0.6	0.2	1.6	1.0	0.8
Depression (Nagel 2018)	0.5	0.7	2.4	0.8	0.0	1.0	0.3	-0.7	-0.4	-1.6
Alzheimer’s Disease (in mother)	0.5	0.5	1.4	-0.5	0.4	0.4	0.8	1.2	-0.3	-1.1
Alzheimer’s Disease (including proxy)	0.5	0.7	2.2	-0.9	-0.3	0.7	0.2	0.5	-1.0	-1.5
Coronary Artery Disease (CAD)	0.5	0.6	2.0	0.0	-0.5	-0.1	-0.7	-0.8	-1.0	-1.4
Type 2 Diabetes (T2D) (2018)	0.5	0.9	3.5	-1.3	-0.3	-0.9	-0.4	1.9	0.1	0.0
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.2	0.7	0.6	1.5	1.0	0.4	0.5	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.2	-0.2	-1.0	-0.7	-1.0	-0.6	-1.1	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	3.2	-0.2	-0.4	-0.2	-0.1	-1.3	0.3	-1.8
Hair/balding pattern: Pattern 2	0.5	0.6	1.7	0.6	0.8	0.5	0.6	0.6	0.9	1.3
Had other major operations	0.5	0.6	2.2	0.4	0.3	-0.0	1.2	1.5	-0.0	0.0
Heart attack	0.5	0.6	1.3	-0.5	0.9	-0.2	0.6	0.9	0.9	1.2
Mouth/teeth dental problems: Dentures	0.5	0.9	1.6	1.0	0.7	0.2	1.1	1.3	-0.2	1.3
Asthma	0.5	1.1	3.5	-0.8	0.8	1.3	0.7	1.9	0.4	0.6
Pulse wave Arterial Stiffness index	0.5	0.6	2.2	0.5	0.3	0.1	0.5	1.2	-0.2	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.6	1.2	-0.8	-0.0	-0.9	-1.0	-1.1	-0.6
Health satisfaction	0.5	0.7	2.5	-0.4	-0.1	-0.3	-1.2	-0.7	0.4	-1.6
Angina (self-reported)	0.5	0.6	1.1	-0.6	-1.1	-0.6	-0.7	0.6	-1.0	0.7
Pulse rate, automated reading	0.5	1.5	5.2	-0.1	-1.0	0.0	-0.7	-1.9	-0.6	-2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.8	-0.0	-0.6	-0.9	-0.4	-1.3	-0.9	0.7
Illnesses of father: Heart disease	0.5	0.6	1.8	-1.2	-0.6	-0.0	-0.4	0.7	-1.3	0.5
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.2	0.7	-0.6	0.1	-0.4	-1.0	0.1	-1.5
Long-standing illness, disability or infirmity	0.5	0.8	2.1	-0.6	0.8	0.5	0.2	1.5	0.7	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.0	-0.3	-1.0	-0.6	-0.7	-1.1	-1.4	-0.4
Hearing aid user	0.5	0.5	0.9	0.5	1.0	0.1	0.3	0.8	0.9	0.9
Basal cell carcinoma (self-reported)	0.5	0.6	1.5	0.9	0.7	1.2	0.6	-0.5	0.9	0.1
Heart disease (siblings)	0.5	0.6	2.3	0.0	-0.8	-0.2	-0.9	-0.5	-1.5	-0.5
Bipolar Disorder (2018)	0.4	0.6	1.5	-1.0	-0.7	-1.2	-0.8	-0.8	0.0	0.3
Bipolar Disorder or Schizophrenia	0.4	0.9	2.1	-1.0	-1.2	-1.4	-1.2	-0.2	-0.3	0.5
Neuroticism (Nagel 2018)	0.4	1.0	4.8	0.5	-0.6	0.0	-0.2	-1.2	-0.4	-2.2
Schizophrenia (2018)	0.4	0.8	1.5	-0.7	-1.2	-1.0	-1.2	0.5	-0.8	0.0
Crohns Disease (2012)	0.4	0.6	1.1	0.6	1.0	0.5	1.0	0.6	0.0	1.1
Triglycerides	0.4	0.7	1.6	-1.2	-0.5	-1.3	-1.0	0.6	0.0	0.4
Type 2 Diabetes (T2D) (2012)	0.4	0.5	2.4	-0.3	0.3	0.0	0.3	1.5	-0.0	0.9
Blood Red Count	0.4	4.1	13.0	-1.4	-1.1	-0.8	-2.2	-3.6	-0.4	-2.7
Chronotype (morning person)	0.4	1.0	2.5	1.3	0.7	1.6	0.8	-0.0	0.6	-1.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.4	-0.9	1.0	0.2	0.3	0.0	1.2	-0.1
Angina	0.4	0.6	0.8	-0.8	-0.8	-0.6	-0.5	0.9	-0.8	0.8
Medication: Co-codamol	0.4	0.4	0.9	-0.8	-0.8	-0.2	-0.8	-0.3	-0.9	-0.0
Average weekly fortified wine intake	0.4	0.4	2.3	-0.1	0.2	0.3	0.7	-0.4	1.5	-0.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.2	-0.6	-1.1	0.0	-0.7	0.6	-0.3	-1.0
Neuroticism score	0.4	0.8	1.9	-0.1	-0.8	-0.9	-0.9	-1.2	-0.4	-1.4
Time employed in main current job	0.4	0.5	0.9	-0.5	-0.5	-0.5	-1.0	-0.5	-0.9	-0.7
Worrier / anxious feelings	0.4	0.7	1.9	0.7	-0.5	-0.1	-0.5	-1.4	-0.3	-1.4
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	3.1	-0.6	-0.5	-0.5	-0.6	0.3	-0.8	-1.8
Medication: Ventolin 100micrograms inhaler	0.4	0.5	2.8	-0.8	0.3	0.1	-0.2	-0.0	-0.0	-1.7
Comparative body size at age 10	0.4	1.1	5.5	-1.0	-0.4	-1.0	-0.5	0.2	-0.2	2.3
Worry too long after embarrassment	0.4	0.6	1.1	0.7	1.0	0.5	0.6	0.6	1.0	1.1
Pulse wave peak to peak time	0.4	0.4	1.8	-0.0	0.1	0.2	-0.2	-1.0	0.4	-1.3
Medication for pain relief, constipation, heartburn	0.4	0.6	2.2	-0.7	-0.8	-1.5	-0.7	-0.0	0.1	0.6
Medication: Blood pressure	0.4	0.7	2.4	1.2	0.3	0.6	0.3	-0.4	-0.3	-1.6
Had major operations	0.4	0.5	1.4	-1.2	-0.4	-0.8	-0.6	0.5	0.0	0.7
Supplements: Vitamin C	0.4	0.5	1.6	1.2	0.1	0.7	-0.0	-0.5	-0.1	-0.9
Ever had bowel cancer screening	0.4	0.5	1.4	0.1	0.6	-0.2	1.1	1.2	0.6	0.4
Back pain experienced in last month	0.4	0.5	1.4	-0.2	-0.5	-0.3	0.2	1.1	-1.2	0.8
Osteoporosis (self-reported)	0.4	0.5	1.0	-0.7	0.2	-0.7	-0.2	0.9	0.7	1.0
Medication: Gliclazide	0.4	0.4	1.5	-0.5	0.3	0.1	0.9	1.2	0.4	0.4
Number of self-reported non-cancer illnesses	0.4	0.7	2.2	1.5	0.7	1.2	0.6	0.2	0.4	-0.5
Financial situation satisfaction	0.4	0.5	1.4	-1.1	-0.6	-0.7	-0.6	-0.1	0.1	-1.2
Supplements: Fish oil (including cod liver oil)	0.4	0.6	2.1	-0.6	-0.8	-1.4	-0.7	-0.2	0.1	-0.6
Basal metabolic rate	0.4	2.4	5.7	-1.5	-1.5	-1.3	-1.9	-1.2	-2.4	-0.3
Number of operations (self-reported)	0.4	0.7	2.5	-0.8	-0.0	-1.0	-0.2	0.6	0.2	1.6
Irritable Bowel Disease (IBD)	0.3	0.8	3.1	-0.2	-0.3	-0.4	-0.3	-1.7	0.1	-1.3
Blood White Count	0.3	2.4	6.1	-0.2	-1.3	-0.5	-1.2	-2.4	-1.3	-2.5
Hearing difficulty/problems: Yes	0.3	0.5	0.9	0.6	0.9	0.7	-0.7	-0.1	0.2	1.0
Medication for hormone replacement therapy	0.3	0.3	1.1	0.3	0.5	0.6	0.1	-0.2	0.7	1.0
Supplements: Zinc	0.3	0.3	1.2	-0.8	-0.5	-1.1	-0.4	-0.4	0.1	0.2
Fed-up feelings	0.3	0.6	1.2	-0.3	-0.9	-0.6	-1.1	-0.6	-0.7	-1.0
Relative age voice broke	0.3	0.4	1.8	-0.1	-0.5	-0.3	-0.9	-1.4	-0.3	0.2
Taking other prescription medications	0.3	0.4	1.7	0.1	0.4	0.1	-0.4	0.6	0.5	-1.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.9	0.2	0.3	0.5	0.1	1.0	0.1	1.0
Qualifications: CSEs or equivalent	0.3	0.4	0.8	-0.9	-0.7	-0.7	-0.5	0.4	-0.5	0.3
Financial difficulties in last 2 years	0.3	0.3	1.2	0.2	-0.2	0.5	0.2	0.8	-0.5	1.1
Number of live births	0.3	0.5	1.1	-0.8	-0.8	-1.1	-0.2	-0.1	-0.9	0.2
Illnesses of mother	0.3	0.3	2.3	-0.0	-0.2	-0.1	0.3	-0.2	0.1	1.5
Hair/balding pattern: Pattern 4	0.3	0.8	1.7	-0.6	-0.8	-1.0	-0.2	0.9	-1.0	-1.3
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	2.1	-1.4	-0.7	-0.9	-0.5	-0.1	-0.3	0.5
Gout (self-reported)	0.3	0.5	1.9	1.4	0.4	0.5	0.4	-0.2	0.8	0.4
Birth weight	0.3	0.6	1.9	-0.6	-0.2	-1.1	-0.6	-0.6	0.5	1.4
Medication: Allopurinol	0.3	0.3	0.9	0.9	0.4	0.1	0.2	-0.3	0.7	0.8
Heart disease (mother)	0.3	0.4	1.2	0.1	0.1	0.6	-0.2	1.1	0.3	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.3	-0.9	-0.6	-0.3	-0.3	1.1	0.1	0.3
Suffer from ‘nerves’	0.3	0.5	2.0	0.8	-0.0	0.9	0.2	0.5	0.2	-1.4
Family relationship satisfaction	0.3	0.4	1.6	-1.2	0.1	-0.2	-0.4	0.5	-0.2	0.8
Hypertension (Self-reported)	0.3	0.8	2.8	1.7	0.5	0.6	0.4	-0.5	0.4	-1.4
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.7	-0.5	0.0	0.2	-0.2	0.3	0.6	1.3
Ever depressed for a whole week	0.3	0.3	1.3	1.1	0.6	0.6	-0.3	-0.3	-0.2	-0.0
Pain experienced in last month	0.3	0.5	0.7	0.8	0.8	0.8	0.5	-0.4	0.9	0.7
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.6	-0.0	0.6	0.0	0.6	-0.5	0.6
Bipolar Disorder (2011)	0.2	0.2	1.4	0.0	0.0	0.0	0.0	0.0	0.0	1.2
Neuroticism (2016)	0.2	0.3	1.0	-0.1	0.4	-0.6	0.6	0.3	1.0	0.0
Primary Biliary Cirrhosis	0.2	0.2	0.6	0.4	0.3	0.5	0.7	-0.8	0.0	0.0
Schizophrenia (2014)	0.2	0.5	1.8	-0.6	-0.8	-0.7	-1.4	-0.1	-0.3	-0.3
Allergy or Eczema	0.2	0.6	2.6	-0.7	0.3	0.5	0.3	1.6	0.4	-0.5
Neuroticism	0.2	0.4	0.8	-0.4	-0.8	-0.9	-0.8	-0.5	-0.1	-0.7
Tanning	0.2	2.3	5.7	1.6	1.5	0.7	2.4	1.2	1.5	1.1
Average weekly spirits intake	0.2	0.3	1.1	0.6	-0.2	-0.2	-0.4	-0.5	0.0	1.0
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	-0.5	0.6	-0.3	-0.5	-0.5	0.3	-0.4
Diabetes (mother)	0.2	0.2	0.4	0.1	0.0	-0.5	-0.7	-0.5	-0.6	0.1
Serious illness, injury or assault to yourself	0.2	0.2	0.8	0.1	0.3	0.1	0.1	0.5	0.4	-0.9
High blood pressure	0.2	0.7	1.8	1.3	0.4	0.3	0.1	-0.7	0.5	-1.3
Multivitamins +/- minerals	0.2	0.3	1.0	-0.4	-0.3	-0.3	0.1	0.2	1.0	-0.6
Medication: Simvastatin	0.2	0.3	0.9	1.0	-0.4	0.3	-0.5	-0.6	-0.5	-0.4
Impedance of arm (right)	0.2	0.8	3.7	0.7	-0.6	-0.7	-0.7	-1.9	0.0	-0.1
Impedance of arm (left)	0.2	0.7	2.4	0.9	-0.4	-0.9	-0.6	-1.5	0.1	0.6
Medication: Paracetamol	0.2	0.3	0.8	-0.3	0.3	0.5	0.3	0.9	0.1	0.7
Headache pain in last month	0.2	0.4	1.5	0.2	-0.2	0.6	-0.0	-0.9	0.1	-1.2
Age at first live birth	0.2	0.4	1.3	-0.2	0.5	0.1	0.4	0.5	1.1	0.9
Neck or shoulder pain in last month	0.2	0.3	0.8	-0.2	0.4	0.2	0.4	0.8	0.9	-0.1
Medication: Seretide 50 evohaler	0.2	0.2	1.1	-0.2	-0.3	0.0	-0.5	0.1	0.0	-1.0
Chest pain or discomfort	0.2	0.3	0.7	-0.7	-0.5	-0.8	-0.3	0.1	0.5	0.4
Age at last live birth	0.2	0.2	1.2	-0.2	0.2	-0.0	0.3	-0.5	1.1	-0.2
Whole body fat-free mass	0.2	0.9	3.0	-0.9	-0.7	-0.5	-1.2	-0.4	-1.7	0.3
Commuting to job workplace: Walk	0.2	0.2	0.8	0.3	-0.0	0.9	0.1	-0.3	-0.4	-0.3
Eye problems/disorders: Cataract	0.2	0.2	0.7	0.2	0.2	0.3	-0.4	-0.9	0.3	0.5
Medication: Aspirin	0.2	0.2	0.6	-0.6	-0.1	-0.0	-0.7	0.0	-0.7	-0.0
Whole body water mass	0.2	0.9	2.8	-0.9	-0.7	-0.5	-1.2	-0.4	-1.7	0.2
Miserableness	0.2	0.3	1.2	0.5	-0.5	-0.5	-0.4	-0.6	-0.1	-1.1
Guilty feelings	0.2	0.3	0.8	-0.8	-0.9	-0.3	-0.5	-0.2	-0.2	-0.7
Wears glasses or contact lenses	0.2	0.2	0.6	0.0	-0.3	-0.2	-0.3	-0.8	-0.5	-0.7
High cholesterol (Self-reported)	0.2	0.3	0.8	0.4	-0.6	0.5	-0.4	0.3	-0.9	0.7
Fractured/broken bones in last 5 years	0.2	0.3	0.7	-0.4	-0.5	-0.8	-0.7	-0.4	-0.1	0.6
Age started oral contraceptive pill	0.2	0.3	1.0	-0.5	-0.3	-0.7	-0.3	-0.3	-0.3	-1.0
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.6	-1.2	-0.4	-0.3	0.0	0.6	-0.6	1.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.6	-0.2	-0.7	-0.8	-0.3	-0.2	-0.5	0.2
Supplements: Calcium	0.2	0.2	0.8	0.9	-0.4	-0.5	-0.2	0.5	0.1	0.3
Impedance of whole body	0.2	1.2	4.0	2.0	0.7	0.8	0.7	-1.0	1.2	-0.3
Crohns Disease (2017)	0.1	0.3	1.0	0.2	0.3	-0.1	1.0	0.1	0.2	1.0
Major Depression (MDD)	0.1	0.1	0.9	0.0	0.0	0.0	0.3	-1.0	0.0	-0.1
HbA1C	0.1	0.1	0.2	0.2	0.3	-0.3	0.5	0.4	-0.4	0.3
HDL Cholesterol	0.1	0.2	0.4	0.1	0.2	0.4	0.3	-0.3	0.6	-0.6
Sensitivity / hurt feelings	0.1	0.2	1.1	1.1	-0.3	0.4	0.1	-0.0	-0.1	0.5
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.4	0.3	-0.0	0.0	0.0	-0.5	-0.7	-0.6
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.1	0.1	-0.2	-0.4	0.1	0.4	0.4
Vitamin and mineral supplements	0.1	0.1	0.3	-0.5	0.3	-0.0	0.0	0.1	-0.5	0.4
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.6	-0.8	0.4	0.6	-0.2	0.6	0.3	-0.3
Stomach or abdominal pain in last month	0.1	0.1	0.6	0.0	-0.4	-0.1	0.1	0.0	-0.8	0.0
Medication: Atenolol	0.1	0.1	0.4	0.0	0.1	-0.1	-0.0	-0.2	0.3	-0.6
Medication: Levothyroxine sodium	0.1	0.2	0.5	0.5	-0.3	0.1	0.1	0.6	-0.7	-0.7
Allergy	0.1	0.3	0.8	0.9	-0.2	-0.7	0.2	-0.5	0.5	0.3
Medication: Ramipril	0.1	0.2	0.5	0.5	0.0	0.5	-0.4	-0.2	0.1	-0.7
Medication: Cholesterol lowering	0.1	0.1	0.3	0.2	-0.2	0.2	-0.2	0.5	-0.5	0.1
Arm fat-free mass (right)	0.1	0.6	2.5	-0.8	-0.4	-0.4	-1.0	-0.2	-1.6	-0.0
Eye problems/disorders: None of the above	0.1	0.1	0.3	-0.4	-0.1	-0.3	-0.3	0.6	0.1	0.2
Medication: Omeprazole	0.1	0.2	0.3	0.1	-0.6	-0.6	-0.1	-0.2	-0.3	-0.5
Arm predicted mass (right)	0.1	0.6	2.4	-0.8	-0.4	-0.4	-0.9	-0.3	-1.5	-0.3
Comparative height size at age 10	0.1	0.4	1.1	0.8	0.1	-0.4	-0.7	-1.1	-0.3	-0.3
Illnesses of siblings: Diabetes	0.1	0.2	0.4	0.1	-0.6	0.1	-0.3	0.2	-0.7	0.4
Qualifications: nursing, teaching	0.1	0.1	0.4	-0.1	0.4	0.7	0.4	0.0	0.0	-0.2
Mineral and other dietary supplements	0.1	0.2	0.5	0.1	0.3	0.7	0.1	-0.6	-0.5	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.5	0.7	0.4	0.2	0.3	-0.1	-0.2	0.3
Medication: Blood pressure	0.1	0.1	0.6	0.7	0.3	-0.2	-0.2	0.4	0.1	0.2
Medication: Lisinopril	0.1	0.2	0.6	-0.5	-0.2	-0.2	0.1	-0.0	-0.6	0.8
Illnesses of father: High blood pressure	0.1	0.1	0.6	0.8	0.2	0.2	0.3	-0.2	-0.1	0.2
Arm fat-free mass (left)	0.1	0.3	1.4	-0.5	-0.1	0.1	-0.5	-0.1	-1.2	-0.4
Commuting to job workplace: Cycle	0.1	0.2	0.8	-0.2	0.0	-0.3	-0.4	0.2	0.4	-0.9
Arm predicted mass (left)	0.1	0.4	1.5	-0.6	-0.2	0.1	-0.6	-0.2	-1.2	-0.5
Blood Eosinophil Count	0.0	0.3	1.6	-0.6	0.1	-0.3	0.2	1.3	-0.2	-0.2
Hair Pigment	0.0	0.2	0.7	-0.8	-0.2	-0.2	0.3	0.7	-0.3	-0.4
Trunk fat-free mass	0.0	0.3	0.7	0.0	0.4	0.6	-0.2	0.6	-0.8	0.5
Hair/balding pattern: Pattern 3	0.0	0.1	0.3	0.1	0.2	0.3	0.6	0.2	-0.2	-0.1
Trunk predicted mass	0.0	0.3	0.6	0.0	0.4	0.7	-0.2	0.6	-0.8	0.5
Medication for cholesterol	0.0	0.1	0.1	-0.2	-0.3	0.0	0.3	0.0	-0.3	0.3
Medication: Paracetamol	0.0	0.1	0.3	-0.3	-0.2	0.1	-0.3	0.0	-0.5	-0.1

Hub : Genes

ANKRD54

Models

Trait associations