Best TWAS P=2.68e-16 · Best GWAS P=9.81e-20 conditioned to 0.0509
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LOC441454 | 0.05 | 0.01 | lasso | 3 | 0.02 | 1.5e-03 | 5.48 | 5.4 | 5.2e-08 | -0.01 | 0.04 | 0.55 | FALSE |
| 2 | GTEx | Artery Tibial | RP11-435O5.5 | 0.09 | 0.04 | lasso | 2 | 0.02 | 7.3e-03 | 8.36 | -8.2 | 2.7e-16 | -0.44 | 0.07 | 0.73 | TRUE |
| 3 | GTEx | Breast Mammary Tissue | CDC14B | 0.16 | 0.02 | enet | 21 | 0.02 | 3.7e-02 | 6.59 | -5.7 | 1.4e-08 | -0.01 | 0.08 | 0.84 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | AAED1 | 0.17 | 0.02 | lasso | 3 | 0.04 | 2.4e-02 | 6.60 | 6.0 | 2.6e-09 | 0.00 | 0.05 | 0.48 | FALSE |
| 5 | GTEx | Liver | PTCH1 | 0.25 | 0.06 | enet | 11 | 0.03 | 4.9e-02 | 9.05 | 6.2 | 6.9e-10 | 0.91 | 0.01 | 0.93 | FALSE |
| 6 | GTEx | Nerve Tibial | HSD17B3 | 0.14 | 0.00 | enet | 20 | 0.00 | 2.4e-01 | 6.42 | 5.5 | 3.7e-08 | 0.04 | 0.08 | 0.38 | FALSE |
| 7 | GTEx | Nerve Tibial | ZNF367 | 0.10 | 0.05 | lasso | 3 | 0.02 | 7.9e-03 | 6.97 | 6.2 | 7.3e-10 | 0.04 | 0.03 | 0.96 | FALSE |
| 8 | GTEx | Spleen | PTCH1 | 0.33 | 0.08 | lasso | 8 | 0.18 | 1.9e-05 | -0.51 | 5.5 | 4.9e-08 | 0.64 | 0.05 | 0.74 | TRUE |
| 9 | GTEx | Testis | HABP4 | 0.19 | 0.22 | lasso | 9 | 0.21 | 1.1e-09 | 6.69 | 6.7 | 2.2e-11 | 0.02 | 0.08 | 0.92 | FALSE |
| 10 | GTEx | Thyroid | CDC14B | 0.15 | 0.10 | lasso | 5 | 0.08 | 5.3e-07 | 6.40 | -6.5 | 6.1e-11 | -0.03 | 0.21 | 0.79 | FALSE |
| 11 | NTR | Blood | PTCH1 | 0.04 | 0.02 | blup | 433 | 0.02 | 4.1e-08 | 6.61 | 5.9 | 3.3e-09 | 0.64 | 0.02 | 0.98 | TRUE |
| 12 | YFS | Blood | ANP32B | 0.03 | 0.02 | lasso | 9 | 0.02 | 1.9e-08 | -4.99 | 5.6 | 1.9e-08 | -0.03 | 0.00 | 0.99 | TRUE |
| 13 | YFS | Blood | HABP4 | 0.08 | 0.09 | enet | 24 | 0.11 | 5.9e-34 | 6.92 | -6.3 | 2.6e-10 | -0.04 | 0.02 | 0.98 | FALSE |
| 14 | YFS | Blood | PTCH1 | 0.09 | 0.05 | lasso | 8 | 0.05 | 1.2e-15 | 6.58 | 7.1 | 1.3e-12 | 0.95 | 0.03 | 0.97 | FALSE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CDC14B | 0.02 | 0.01 | lasso | 1 | 0.01 | 3.0e-03 | 6.82 | -6.8 | 8.9e-12 | -0.03 | 0.03 | 0.58 | FALSE |
| 16 | The Cancer Genome Atlas | Glioblastoma Multiforme | CDC14B | 0.16 | 0.17 | blup | 41 | 0.19 | 2.6e-06 | 6.60 | -6.0 | 2.0e-09 | 0.00 | 0.05 | 0.92 | FALSE |
| 17 | The Cancer Genome Atlas | Glioblastoma Multiforme | HABP4 | 0.08 | 0.06 | blup | 44 | 0.05 | 1.6e-02 | 6.29 | -6.9 | 4.3e-12 | -0.05 | 0.03 | 0.51 | FALSE |
| 18 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HABP4 | 0.02 | 0.02 | blup | 44 | 0.02 | 7.1e-03 | 6.60 | 6.9 | 3.9e-12 | 0.02 | 0.03 | 0.65 | FALSE |
| 19 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CDC14B | 0.03 | 0.02 | blup | 42 | 0.02 | 2.1e-03 | 6.60 | -6.9 | 4.0e-12 | -0.03 | 0.04 | 0.64 | FALSE |
| 20 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CDC14B | 0.05 | 0.06 | lasso | 5 | 0.06 | 6.5e-07 | 6.57 | -5.9 | 4.7e-09 | -0.01 | 0.07 | 0.93 | FALSE |
| 21 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HABP4 | 0.05 | 0.08 | lasso | 5 | 0.08 | 6.9e-09 | 6.21 | -6.4 | 2.0e-10 | -0.04 | 0.10 | 0.90 | FALSE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PTCH1 | 0.02 | 0.01 | blup | 54 | 0.02 | 1.1e-03 | 7.09 | -7.0 | 2.3e-12 | -0.19 | 0.04 | 0.33 | FALSE |
| 23 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CDC14B | 0.08 | 0.02 | blup | 41 | 0.04 | 1.0e-03 | 5.48 | -7.2 | 4.6e-13 | -0.05 | 0.02 | 0.60 | TRUE |
| 24 | The Cancer Genome Atlas | Thyroid Carcinoma | CDC14B | 0.05 | 0.07 | blup | 42 | 0.08 | 4.8e-08 | 6.64 | -6.7 | 2.7e-11 | -0.02 | 0.05 | 0.95 | FALSE |