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chr9:97,520,168-101,477,500

Best TWAS P=2.68e-16 · Best GWAS P=9.81e-20 conditioned to 0.0509

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	GTEx	Artery Tibial	RP11-435O5.5	0.09	0.04	lasso	2	0.02	7.3e-03	8.36	-8.2	2.7e-16	-0.44	0.07	0.73	TRUE
23	The Cancer Genome Atlas	Stomach Adenocarcinoma	CDC14B	0.08	0.02	blup	41	0.04	1.0e-03	5.48	-7.2	4.6e-13	-0.05	0.02	0.60	TRUE
11	NTR	Blood	PTCH1	0.04	0.02	blup	433	0.02	4.1e-08	6.61	5.9	3.3e-09	0.64	0.02	0.98	TRUE
12	YFS	Blood	ANP32B	0.03	0.02	lasso	9	0.02	1.9e-08	-4.99	5.6	1.9e-08	-0.03	0.00	0.99	TRUE
8	GTEx	Spleen	PTCH1	0.33	0.08	lasso	8	0.18	1.9e-05	-0.51	5.5	4.9e-08	0.64	0.05	0.74	TRUE
14	YFS	Blood	PTCH1	0.09	0.05	lasso	8	0.05	1.2e-15	6.58	7.1	1.3e-12	0.95	0.03	0.97	FALSE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	PTCH1	0.02	0.01	blup	54	0.02	1.1e-03	7.09	-7.0	2.3e-12	-0.19	0.04	0.33	FALSE
18	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HABP4	0.02	0.02	blup	44	0.02	7.1e-03	6.60	6.9	3.9e-12	0.02	0.03	0.65	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CDC14B	0.03	0.02	blup	42	0.02	2.1e-03	6.60	-6.9	4.0e-12	-0.03	0.04	0.64	FALSE
17	The Cancer Genome Atlas	Glioblastoma Multiforme	HABP4	0.08	0.06	blup	44	0.05	1.6e-02	6.29	-6.9	4.3e-12	-0.05	0.03	0.51	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	CDC14B	0.02	0.01	lasso	1	0.01	3.0e-03	6.82	-6.8	8.9e-12	-0.03	0.03	0.58	FALSE
9	GTEx	Testis	HABP4	0.19	0.22	lasso	9	0.21	1.1e-09	6.69	6.7	2.2e-11	0.02	0.08	0.92	FALSE
24	The Cancer Genome Atlas	Thyroid Carcinoma	CDC14B	0.05	0.07	blup	42	0.08	4.8e-08	6.64	-6.7	2.7e-11	-0.02	0.05	0.95	FALSE
10	GTEx	Thyroid	CDC14B	0.15	0.10	lasso	5	0.08	5.3e-07	6.40	-6.5	6.1e-11	-0.03	0.21	0.79	FALSE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	HABP4	0.05	0.08	lasso	5	0.08	6.9e-09	6.21	-6.4	2.0e-10	-0.04	0.10	0.90	FALSE
13	YFS	Blood	HABP4	0.08	0.09	enet	24	0.11	5.9e-34	6.92	-6.3	2.6e-10	-0.04	0.02	0.98	FALSE
5	GTEx	Liver	PTCH1	0.25	0.06	enet	11	0.03	4.9e-02	9.05	6.2	6.9e-10	0.91	0.01	0.93	FALSE
7	GTEx	Nerve Tibial	ZNF367	0.10	0.05	lasso	3	0.02	7.9e-03	6.97	6.2	7.3e-10	0.04	0.03	0.96	FALSE
16	The Cancer Genome Atlas	Glioblastoma Multiforme	CDC14B	0.16	0.17	blup	41	0.19	2.6e-06	6.60	-6.0	2.0e-09	0.00	0.05	0.92	FALSE
4	GTEx	Cells EBV-transformed lymphocytes	AAED1	0.17	0.02	lasso	3	0.04	2.4e-02	6.60	6.0	2.6e-09	0.00	0.05	0.48	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	CDC14B	0.05	0.06	lasso	5	0.06	6.5e-07	6.57	-5.9	4.7e-09	-0.01	0.07	0.93	FALSE
3	GTEx	Breast Mammary Tissue	CDC14B	0.16	0.02	enet	21	0.02	3.7e-02	6.59	-5.7	1.4e-08	-0.01	0.08	0.84	FALSE
6	GTEx	Nerve Tibial	HSD17B3	0.14	0.00	enet	20	0.00	2.4e-01	6.42	5.5	3.7e-08	0.04	0.08	0.38	FALSE
1	CommonMind	Brain Pre-frontal Cortex	LOC441454	0.05	0.01	lasso	3	0.02	1.5e-03	5.48	5.4	5.2e-08	-0.01	0.04	0.55	FALSE