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chr18:20,082,830-21,863,589

Best TWAS P=5.87e-22 · Best GWAS P=4.41e-25 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
34	GTEx	Testis	C18orf8	0.12	0.07	lasso	6	0.08	1.9e-04	-7.7	-9.6	5.9e-22	0.43	0.18	0.44	TRUE
21	GTEx	Esophagus Mucosa	NPC1	0.09	0.04	lasso	3	0.05	1.5e-04	-7.4	-8.0	1.9e-15	0.30	0.57	0.02	TRUE
26	GTEx	Nerve Tibial	TMEM241	0.16	0.04	enet	10	0.07	1.8e-05	-6.0	-7.2	8.7e-13	0.48	0.70	0.02	TRUE
9	GTEx	Artery Tibial	C18orf8	0.18	0.12	lasso	3	0.10	1.5e-08	6.6	-6.5	7.5e-11	0.14	1.00	0.00	TRUE
2	CommonMind	Brain Pre-frontal Cortex	NPC1	0.08	0.07	lasso	3	0.08	5.2e-10	6.6	-5.9	3.1e-09	0.12	1.00	0.00	TRUE
45	The Cancer Genome Atlas	Brain Lower Grade Glioma	CABLES1	0.06	0.02	enet	12	0.04	6.8e-05	3.4	-5.5	4.3e-08	0.26	0.07	0.03	TRUE
23	GTEx	Esophagus Muscularis	NPC1	0.11	0.07	enet	4	0.09	7.3e-06	-8.0	-8.2	3.2e-16	0.25	0.76	0.01	FALSE
13	GTEx	Brain Cerebellum	C18orf8	0.23	0.18	enet	13	0.21	9.9e-07	-7.7	-8.2	3.3e-16	0.26	0.82	0.04	FALSE
5	GTEx	Adipose Subcutaneous	C18orf8	0.17	0.16	enet	13	0.16	2.6e-13	-7.7	-8.1	5.5e-16	0.23	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	RIOK3	0.02	0.01	bslmm	348	0.00	1.8e-01	-6.5	-8.1	6.2e-16	0.44	0.14	0.05	FALSE
12	GTEx	Brain Cerebellar Hemisphere	C18orf8	0.27	0.34	enet	19	0.34	1.3e-09	-7.7	-8.0	1.1e-15	0.24	0.96	0.00	FALSE
11	GTEx	Brain Caudate basal ganglia	C18orf8	0.15	0.16	enet	11	0.11	5.9e-04	-7.8	-8.0	1.8e-15	0.22	0.44	0.04	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C18orf8	0.26	0.35	lasso	6	0.40	1.9e-52	-7.8	-7.9	2.2e-15	0.22	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NPC1	0.03	0.04	lasso	2	0.05	4.2e-06	-7.6	-7.9	2.5e-15	0.27	0.02	0.98	FALSE
31	GTEx	Skin Not Sun Exposed Suprapubic	NPC1	0.15	0.08	lasso	4	0.12	2.3e-07	-7.7	-7.9	2.7e-15	0.23	0.99	0.00	FALSE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	NPC1	0.07	0.08	lasso	3	0.10	1.6e-11	6.6	-7.9	3.4e-15	0.20	0.04	0.96	FALSE
16	GTEx	Brain Cortex	C18orf8	0.19	0.18	lasso	5	0.13	1.8e-04	-7.8	-7.8	4.6e-15	0.23	0.48	0.03	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	C18orf8	0.21	0.27	enet	6	0.23	6.9e-13	-7.7	-7.8	4.8e-15	0.24	1.00	0.00	FALSE
32	GTEx	Skin Sun Exposed Lower leg	C18orf8	0.35	0.33	enet	23	0.36	1.7e-30	-7.8	-7.8	7.4e-15	0.24	1.00	0.00	FALSE
24	GTEx	Heart Left Ventricle	NPC1	0.19	0.15	enet	12	0.17	1.6e-09	-7.7	-7.8	8.3e-15	0.26	1.00	0.00	FALSE
19	GTEx	Breast Mammary Tissue	NPC1	0.27	0.13	enet	27	0.19	5.0e-10	-7.4	-7.8	8.6e-15	0.22	1.00	0.00	FALSE
7	GTEx	Adipose Visceral Omentum	C18orf8	0.18	0.11	enet	10	0.04	4.5e-03	-8.0	-7.7	1.5e-14	0.30	0.85	0.01	FALSE
20	GTEx	Breast Mammary Tissue (Female)	NPC1	0.43	0.24	lasso	3	0.27	1.1e-08	-7.3	-7.7	1.5e-14	0.26	0.98	0.00	FALSE
28	GTEx	Nerve Tibial	NPC1	0.19	0.12	lasso	6	0.16	1.1e-11	6.6	-7.7	1.6e-14	0.21	1.00	0.00	FALSE
33	GTEx	Skin Sun Exposed Lower leg	NPC1	0.23	0.18	lasso	3	0.27	1.8e-22	-7.4	-7.6	2.3e-14	0.23	1.00	0.00	FALSE
29	GTEx	Pancreas	NPC1	0.33	0.14	lasso	7	0.12	1.1e-05	-7.7	-7.5	9.1e-14	0.24	0.81	0.01	FALSE
8	GTEx	Adipose Visceral Omentum	NPC1	0.20	0.19	lasso	3	0.17	2.9e-09	-7.4	-7.4	1.0e-13	0.24	1.00	0.00	FALSE
6	GTEx	Adipose Subcutaneous	NPC1	0.27	0.27	enet	12	0.30	2.4e-25	-7.4	-7.4	1.1e-13	0.25	1.00	0.00	FALSE
25	GTEx	Lung	NPC1	0.11	0.06	enet	11	0.04	2.3e-04	-7.8	-7.4	1.8e-13	0.21	0.99	0.00	FALSE
22	GTEx	Esophagus Muscularis	C18orf8	0.14	0.13	lasso	3	0.10	8.0e-07	6.6	-7.3	2.0e-13	0.17	0.96	0.00	FALSE
40	The Cancer Genome Atlas	Esophageal Carcinoma	NPC1	0.16	0.10	lasso	3	0.10	3.7e-04	6.6	-7.3	2.0e-13	0.19	0.05	0.65	FALSE
17	GTEx	Brain Frontal Cortex BA9	C18orf8	0.42	0.30	enet	12	0.08	3.4e-03	-7.7	-7.3	3.6e-13	0.22	0.90	0.01	FALSE
27	GTEx	Nerve Tibial	C18orf8	0.16	0.07	enet	21	0.09	3.9e-07	-7.3	-7.2	4.8e-13	0.12	1.00	0.00	FALSE
39	The Cancer Genome Atlas	Breast Invasive Carcinoma	NPC1	0.03	0.03	blup	69	0.04	2.9e-09	-7.7	-7.2	6.9e-13	0.24	0.03	0.97	FALSE
38	METSIM	Adipose	NPC1	0.06	0.05	enet	18	0.05	6.4e-08	-7.9	-6.8	8.7e-12	0.22	1.00	0.00	FALSE
14	GTEx	Brain Cerebellum	NPC1	0.20	0.10	enet	9	0.12	1.9e-04	-7.7	-6.8	8.8e-12	0.23	0.42	0.05	FALSE
37	METSIM	Adipose	C18orf8	0.08	0.02	enet	23	0.04	1.0e-06	6.6	-6.8	1.2e-11	0.26	0.80	0.01	FALSE
47	The Cancer Genome Atlas	Prostate Adenocarcinoma	NPC1	0.05	0.02	blup	65	0.03	9.9e-04	-7.6	-6.8	1.3e-11	0.25	0.02	0.73	FALSE
48	The Cancer Genome Atlas	Thyroid Carcinoma	NPC1	0.04	0.03	blup	70	0.05	9.4e-06	-7.7	-6.7	2.7e-11	0.21	0.03	0.97	FALSE
44	The Cancer Genome Atlas	Brain Lower Grade Glioma	C18orf8	0.07	0.05	lasso	5	0.03	9.5e-05	6.6	-6.5	6.2e-11	0.15	0.27	0.70	FALSE
35	GTEx	Thyroid	NPC1	0.20	0.10	enet	25	0.13	2.3e-10	-7.8	-6.2	6.3e-10	0.10	1.00	0.00	FALSE
10	GTEx	Artery Tibial	NPC1	0.26	0.07	enet	31	0.11	3.7e-09	6.6	-6.2	6.8e-10	0.02	1.00	0.00	FALSE
36	GTEx	Vagina	NPC1	0.27	0.09	lasso	7	0.14	4.9e-04	-5.1	-6.2	7.0e-10	0.37	0.23	0.10	FALSE
4	GTEx	Adipose Subcutaneous	TMEM241	0.07	0.00	enet	12	0.01	4.1e-02	-5.5	-5.7	1.2e-08	0.33	0.32	0.11	FALSE
18	GTEx	Brain Nucleus accumbens basal ganglia	TMEM241	0.17	0.02	lasso	6	-0.01	5.6e-01	-7.7	-5.6	1.7e-08	0.24	0.10	0.06	FALSE
41	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NPC1	0.05	0.02	blup	66	0.03	1.4e-04	-7.6	-5.6	1.7e-08	0.24	0.10	0.76	FALSE
15	GTEx	Brain Cortex	TMEM241	0.37	0.12	enet	19	0.22	1.3e-06	2.0	-5.6	2.4e-08	0.26	0.67	0.04	FALSE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	C18orf45	0.04	0.02	lasso	3	0.03	2.7e-04	4.7	-5.4	6.7e-08	0.34	0.70	0.02	FALSE