Hub : Genes

CABLES1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.1055	0.0356	9.1e-06	0.050	0.049	0.068	0.052	0.061	4.3e-07	6.2e-07	4.1e-09	2.7e-07	2.6e-08
2	TCGA	Brain Lower Grade Glioma	0.0576	0.0264	1.8e-03	0.021	0.030	0.035	NA	0.033	1.6e-03	2.1e-04	6.8e-05	NA	9.7e-05
3	TCGA	Prostate Adenocarcinoma	0.1000	0.0420	8.5e-03	-0.003	0.001	0.012	NA	0.001	9.6e-01	2.3e-01	2.0e-02	NA	2.6e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.7	1.1	3.0	-1.7	0.3	0.4
Bipolar Disorder or Schizophrenia	0.7	1.6	2.7	-1.6	-1.2	-0.9
Depressed Affect (Nagel 2018)	0.3	0.6	0.8	-0.8	-0.5	0.9
Depression (Nagel 2018)	1.0	1.5	2.0	-1.4	-1.2	0.9
Intelligence (Savage-Jansen 2018)	0.9	2.7	3.7	-1.9	1.9	-0.8
Neuroticism (Nagel 2018)	1.6	3.7	8.0	-1.6	-2.8	0.7
Schizophrenia (2018)	1.1	2.2	3.3	-0.6	-1.8	-1.7
Schizophrenia vs Biploar Disorder	5.2	6.9	17.9	4.2	-0.8	-1.4
Worry (Nagel 2018)	2.4	5.0	14.6	-0.7	-3.8	0.1
Alzheimer’s Disease (in mother)	1.0	1.1	2.8	0.5	0.6	1.7
Alzheimer’s Disease (in father)	0.3	0.3	0.6	-0.4	-0.8	-0.3
Alzheimer’s Disease (including proxy)	0.5	0.7	2.0	-0.1	0.4	1.4
Crohns Disease (2017)	0.2	0.4	0.9	-0.4	-1.0	0.4
Irritable Bowel Disease (IBD)	0.1	0.3	0.9	0.2	-1.0	-0.3
Ulcerative Colitis (UC)	0.2	0.3	0.6	0.3	-0.5	-0.8
Major Depression (MDD)	0.8	0.9	1.7	0.3	1.3	1.0
Reaction Time	1.0	1.9	5.5	0.6	-0.2	-2.3
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.4	-0.4	1.2	-0.3
Breast Cancer	0.4	1.0	1.9	1.4	-0.0	1.0
Ovarian Cancer	1.0	1.4	3.9	-2.0	-0.4	0.1
Prostate Cancer	0.6	0.8	1.5	-0.3	-1.2	-0.8
Age at First Birth	0.5	0.7	1.7	0.5	1.3	0.4
Bipolar Disorder (2011)	4.2	4.1	12.2	-3.5	0.4	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.2	-0.0	-0.1	1.1
Coronary Artery Disease (CAD)	0.6	0.8	1.5	-1.2	-0.8	-0.5
Crohns Disease (2012)	0.1	0.2	0.4	-0.4	-0.6	-0.4
Mean Putamen Volume	1.3	1.4	3.9	-0.5	-0.5	2.0
Fasting Glucose	0.3	0.4	0.5	0.7	-0.4	0.6
HbA1C	0.5	0.6	1.6	0.0	-1.3	0.2
HDL Cholesterol	3.7	6.1	13.8	0.4	3.7	-2.1
LDL Cholesterol	0.5	0.7	1.5	0.5	-0.6	1.2
Lupus	0.6	1.0	2.0	0.9	-0.3	1.4
Neuroticism (2016)	0.3	0.4	1.1	-0.2	-1.1	0.3
Primary Biliary Cirrhosis	0.3	0.4	0.6	0.6	-0.5	-0.8
Rheumatoid Arthritis	1.6	2.2	4.4	2.1	-1.0	1.1
Schizophrenia (2014)	0.8	1.7	4.2	-0.3	-0.9	-2.0
Triglycerides	0.9	1.4	3.1	0.9	-0.5	1.8
Type 2 Diabetes (T2D) (2012)	1.0	1.1	1.8	-0.4	-1.3	1.2
Ulcerative Colitis	1.0	1.4	4.0	-0.6	-0.1	-2.0
Blood Eosinophil Count	0.4	2.8	6.2	0.0	-2.5	1.5
Blood Platelet Count	2.8	32.8	88.8	-2.9	-1.1	9.4
Blood Red Count	0.0	0.3	0.6	0.2	-0.8	0.6
Blood White Count	0.6	4.7	9.9	-1.9	-0.8	3.1
Heel T-Score	0.6	5.1	8.0	-2.8	2.5	1.0
BMI	1.0	6.0	10.9	-1.3	-3.3	2.3
Height	5.1	98.2	136.9	8.1	-11.7	-9.6
Waist Hip Ratio (WHR)	2.1	9.5	24.8	1.8	-5.0	-0.6
Systolic Blood Pressure	0.1	0.7	1.2	0.3	-1.1	0.8
Smoking Status	2.8	6.8	11.0	-3.3	-3.0	0.8
Allergy or Eczema	0.0	0.1	0.1	-0.2	-0.1	0.3
Cardiovascular Disease	0.3	1.1	2.5	0.1	-1.6	0.9
Hypothyroidism (self reported)	1.8	4.2	8.4	-0.7	-2.9	-1.9
Respiratory disease	0.4	0.9	1.9	1.4	0.1	-0.9
Type 2 Diabetes (T2D) (2018)	0.8	1.4	3.0	-0.2	-1.7	1.1
Lung FEV1/FVC ratio	0.0	0.2	0.3	0.5	0.5	0.3
Lung FVC	1.4	6.9	10.0	-1.7	3.2	2.8
Neuroticism	1.0	2.5	5.9	-0.4	-2.4	1.2
Chronotype (morning person)	0.1	0.2	0.5	0.2	0.7	0.2
Hair Pigment	0.0	0.5	0.6	0.8	0.7	0.6
Tanning	0.3	4.2	6.7	-2.4	-0.5	-2.6
Hand grip strength (left)	1.6	4.1	7.5	1.9	-2.7	-1.1
Number of treatments/medications taken	1.5	2.7	6.2	-1.4	-2.5	0.0
Average weekly spirits intake	0.7	0.8	1.9	-0.6	-0.4	-1.4
Sensitivity / hurt feelings	0.7	1.3	1.6	-1.0	-1.3	1.1
Frequency of depressed mood in last 2 weeks	2.8	3.9	6.1	-1.8	-2.5	1.5
Hearing difficulty/problems: Yes	2.3	3.6	7.7	0.2	-2.8	-1.7
Relative age of first facial hair	1.7	3.5	5.4	1.1	2.3	2.0
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.6	0.4	-1.3	0.2
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.7	-0.7	-0.9	-0.1
Ever had hysterectomy (womb removed)	0.7	0.8	1.4	0.1	-1.0	1.2
Systolic blood pressure, automated reading	0.2	0.5	0.7	-0.7	-0.8	0.5
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	2.2	1.5	-1.2	-1.2
Angina	0.2	0.3	0.4	0.4	-0.6	-0.6
Medication for hormone replacement therapy	1.5	1.7	3.8	-0.6	-1.9	0.9
Vitamin and mineral supplements	1.0	1.3	3.1	0.7	0.7	1.7
Supplements: Zinc	0.5	0.5	1.4	0.1	1.2	-0.4
Medication: Co-codamol	2.0	2.3	6.4	-0.3	-2.5	-0.7
Medication: Metformin	1.4	2.0	4.4	-0.7	-2.1	1.0
Diabetes (father)	0.3	0.4	0.9	0.0	0.5	1.0
Diabetes (mother)	1.4	1.7	3.8	0.7	-1.9	-0.9
Severe depression (siblings)	0.5	0.5	1.5	0.2	-1.2	-0.1
Pack years adult smoking proportion	0.7	1.0	2.3	1.5	-0.4	0.8
Impedance of leg (right)	0.4	2.0	5.7	2.4	0.4	0.4
Leg fat-free mass (left)	2.6	13.8	30.4	1.5	-5.5	-3.0
Trunk fat percentage	1.0	3.8	6.6	2.2	-2.6	0.3
Hand grip strength (right)	1.2	3.3	7.5	1.1	-2.7	-1.1
Townsend deprivation index at recruitment	0.2	0.3	0.7	0.3	-0.8	-0.5
Current tobacco smoking	2.7	4.5	8.2	-2.9	-2.3	-0.3
Average weekly fortified wine intake	0.7	0.8	2.3	0.2	1.5	0.0
Maternal smoking around birth	0.2	0.3	0.6	-0.4	0.5	0.7
Fed-up feelings	1.0	1.8	2.2	-1.4	-1.1	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	4.1	-1.2	-2.0	0.8
Relative age voice broke	0.9	1.4	3.7	-0.7	0.2	1.9
Taking other prescription medications	1.7	2.6	5.7	-1.2	-2.4	0.8
Age when periods started (menarche)	0.1	0.3	0.5	-0.7	0.1	-0.6
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.0	0.8	-1.4	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.5	0.2	-1.2	-0.0
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.4	0.6	-1.6	0.6
Qualifications: CSEs or equivalent	0.8	1.1	3.0	1.7	-0.3	0.4
Serious illness, injury or assault to yourself	2.9	3.5	9.7	0.9	-3.1	0.0
High blood pressure	1.2	3.4	6.0	-1.7	-2.4	1.1
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.8	-0.6	-0.5	1.3
Multivitamins +/- minerals	0.6	0.7	1.9	-0.5	-1.4	-0.3
Stomach or abdominal pain in last month	0.7	0.9	1.6	1.3	-1.0	0.4
Supplements: Glucosamine	0.7	0.9	2.3	0.3	1.5	0.5
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.4	-0.1	-0.7	-0.6
Medication: Atenolol	1.4	1.8	2.4	1.3	1.5	-1.1
Medication: Levothyroxine sodium	2.3	3.9	7.3	-0.2	-2.7	-2.1
Sitting height	0.8	5.8	9.4	1.6	-3.1	-2.3
Chronic bronchitis/emphysema (father)	2.5	3.0	5.9	2.4	-0.7	-1.6
High blood pressure (mother)	0.3	0.4	0.5	-0.7	-0.4	0.7
Body mass index (BMI)	0.7	3.1	8.0	-0.4	-2.8	1.1
Impedance of leg (left)	0.6	2.9	8.3	2.9	0.1	0.6
Leg predicted mass (left)	2.6	13.9	30.5	1.5	-5.5	-3.0
Trunk fat mass	2.0	8.5	18.5	2.6	-4.3	-0.5
Waist circumference	3.7	13.6	36.8	1.9	-6.1	-0.7
Number of incorrect matches in round	0.7	1.1	1.8	1.2	-1.3	0.4
Past tobacco smoking	2.7	5.0	8.6	2.9	2.5	-0.6
Alcohol usually taken with meals	0.1	0.2	0.6	0.3	0.7	-0.0
Nervous feelings	2.2	4.2	11.3	-1.1	-3.4	-0.2
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.1	7.5	-0.7	-2.7	-1.1
Hearing difficulty/problems with background noise	1.4	2.3	6.3	-0.2	-2.5	-0.7
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	0.4	-0.4	0.0
Had menopause	0.9	1.2	2.3	1.5	-0.9	-0.6
Had other major operations	0.3	0.4	1.0	0.0	-0.4	1.0
Forced vital capacity (FVC)	0.1	0.2	0.4	0.1	-0.6	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.3	-0.0	-0.5	-0.1
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.4	0.0	-0.4	0.6
Qualifications: None of the above	0.3	0.7	1.4	0.8	-0.3	1.2
Financial difficulties in last 2 years	1.4	1.9	3.5	-0.9	-1.9	1.2
Mouth/teeth dental problems	1.4	2.2	6.3	-0.4	2.5	-0.3
Heart attack	0.6	0.8	1.1	-0.3	-1.1	1.0
Allergy	0.1	0.3	0.5	0.3	0.4	-0.7
Pain all over the body in last month	2.3	2.5	5.6	-0.6	-2.4	1.2
Diabetes (self-reported)	0.7	1.1	3.3	0.1	-1.8	-0.2
Hayfever/allergic rhinitis (self-reported)	1.7	2.3	3.8	1.6	0.6	1.9
Medication: Ramipril	0.4	0.5	0.7	-0.9	-0.1	0.8
Medication: Simvastatin	1.1	1.6	4.0	-0.9	-0.1	-2.0
Fluid intelligence score	0.1	0.2	0.3	-0.6	0.1	-0.4
Illnesses of siblings	0.4	0.6	0.9	-0.9	0.9	-0.1
Neuroticism score	2.2	4.6	11.0	-1.7	-3.3	-0.1
Weight	2.9	14.4	32.8	2.7	-5.7	-1.7
Impedance of arm (right)	0.9	4.3	11.1	1.2	3.3	-0.5
Arm fat percentage (right)	0.5	1.9	4.4	-0.2	-2.1	1.1
Trunk fat-free mass	4.4	25.5	51.1	3.0	-7.2	-4.1
Hip circumference	1.5	6.7	14.9	2.2	-3.9	-0.2
Time employed in main current job	2.0	2.3	3.9	2.0	-0.7	-1.6
Alcohol intake versus 10 years previously	0.3	0.5	1.0	-1.0	-0.3	0.6
Father’s age at death	1.0	1.4	3.2	0.5	1.8	0.8
Worrier / anxious feelings	2.7	5.0	13.2	-1.4	-3.6	-0.1
Frequency of tiredness / lethargy in last 2 weeks	2.5	4.1	6.5	-2.6	-2.2	1.0
Falls in the last year	3.4	4.6	9.8	0.5	-3.1	-2.0
Hair/balding pattern: Pattern 3	1.0	1.6	4.1	0.8	-0.2	-2.0
Number of live births	0.2	0.3	0.5	-0.7	0.0	0.6
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.2	0.4	-0.1	-0.1
Pulse rate	0.2	0.3	0.8	-0.4	0.9	0.3
Happiness	0.9	1.1	2.1	-0.5	-1.5	-0.9
Noisy workplace	1.1	1.3	2.4	0.9	1.5	-0.9
Qualifications: A levels/AS levels or equivalent	1.5	3.3	7.9	-2.8	1.4	-0.4
Serious illness, injury or assault of a close relative in last 2 years	2.6	3.0	8.8	-0.5	-3.0	-0.2
Mouth/teeth dental problems: Dentures	0.8	1.4	3.2	-0.6	-1.8	-0.7
Asthma	0.3	0.5	1.3	-0.3	0.2	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	1.1	-0.5	-1.0	1.1
Medication: Cholesterol lowering	0.5	0.7	1.2	-0.7	1.1	0.7
Depression (self-reported)	0.4	0.5	1.5	-1.2	-0.3	-0.0
Medication: Lansoprazole	0.8	0.9	1.2	-0.6	-1.0	1.1
Prospective memory result	0.9	1.1	2.3	1.5	0.1	1.0
Lung cancer (father)	4.4	5.1	9.8	1.8	1.5	3.1
Illnesses of mother	0.1	0.1	0.3	-0.6	-0.1	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.4	0.7	-0.6	0.1
Pulse wave Arterial Stiffness index	0.4	0.5	0.6	-0.8	-0.4	0.8
Impedance of arm (left)	1.1	5.2	12.3	1.7	3.5	-0.6
Arm fat mass (right)	1.4	5.8	16.4	1.1	-4.0	-0.1
Trunk predicted mass	4.4	25.2	50.6	3.0	-7.1	-4.0
Standing height	4.8	47.6	53.4	7.3	-6.9	-6.5
Length of working week for main job	0.5	0.5	0.7	0.5	-0.8	0.8
Exposure to tobacco smoke at home	0.4	0.5	1.4	-0.2	0.0	1.2
Breastfed as a baby	0.3	0.4	0.4	-0.7	0.5	-0.6
Tense / ‘highly strung’	0.6	1.0	1.4	1.2	-1.2	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.5	-0.4	-0.7	-0.7
Hair/balding pattern: Pattern 4	0.3	0.7	1.5	-1.2	0.6	0.6
Birth weight of first child	0.6	1.1	2.8	0.0	1.7	-0.6
Peak expiratory flow (PEF)	0.1	0.2	0.7	-0.8	-0.2	0.1
Pulse wave reflection index	0.6	0.7	2.2	-1.5	0.3	0.1
Ever highly irritable/argumentative for 2 days	1.7	2.1	3.6	-0.1	-1.6	-1.9
Loud music exposure frequency	0.6	0.6	1.0	-0.2	-1.0	-0.9
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.5	-1.2	0.1	1.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.7	-0.7	-1.3	0.5
Blood clot in the leg (DVT)	0.3	0.4	1.0	-0.3	-1.0	-0.3
Medication: Paracetamol	1.8	2.9	5.1	-1.8	-2.3	-0.6
Headache pain in last month	0.0	0.0	0.1	-0.1	-0.0	0.3
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.8	0.3	-0.9	-1.7
Glaucoma (self-reported)	2.7	3.1	4.8	2.2	-1.0	1.9
Gout (self-reported)	0.5	0.7	1.7	0.4	-1.3	-0.4
Hypothyroidism/myxoedema (self-reported)	2.3	4.4	6.2	-1.3	-2.5	-2.3
Medication: Amlodipine	1.2	1.7	4.0	-1.1	-2.0	0.2
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.5	0.7	-0.7	0.3
Birth weight	1.5	3.2	4.8	2.1	-0.6	-2.2
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	-0.7	0.0	0.4
High blood pressure (siblings)	0.1	0.2	0.3	0.1	-0.5	0.5
Forced vital capacity (FVC), Best measure	0.2	0.6	1.3	0.4	-1.1	-0.5
Body fat percentage	1.0	4.0	8.3	1.6	-2.9	1.0
Leg fat percentage (right)	1.3	4.8	9.2	0.6	-3.0	2.2
Arm fat-free mass (right)	4.6	23.6	51.1	3.1	-7.2	-3.2
Exposure to tobacco smoke outside home	0.8	1.0	1.7	-0.2	-1.3	1.2
Comparative body size at age 10	0.1	0.3	0.6	-0.4	-0.4	0.7
Number of full brothers	1.2	1.5	3.4	0.9	-1.8	0.6
Worry too long after embarrassment	4.3	7.3	16.2	-2.4	-4.0	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.4	0.7	0.3	-0.6
Wheeze or whistling in the chest in last year	0.7	1.2	1.7	0.9	-1.1	-1.3
Number of children fathered	0.7	0.8	2.3	-1.5	-0.5	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.5	-0.1	0.3
Age at first live birth	0.2	0.3	0.6	-0.5	0.1	-0.7
Pulse wave peak to peak time	1.1	1.3	2.2	1.3	-0.1	-1.5
Health satisfaction	0.2	0.3	0.9	-0.2	0.1	0.9
Shortness of breath walking on level ground	1.6	1.9	3.9	2.0	-0.2	1.3
Qualifications: College or University degree	0.7	2.3	4.5	-2.1	0.1	-1.5
Eye problems/disorders: None of the above	0.6	0.7	1.0	-0.8	-0.6	-1.0
Mouth/teeth dental problems: Loose teeth	0.8	1.0	2.6	0.5	-1.6	-0.1
Emphysema/chronic bronchitis	0.1	0.1	0.4	0.6	-0.0	0.1
Medication for pain relief, constipation, heartburn	0.9	1.6	4.2	0.7	2.1	-0.1
Neck or shoulder pain in last month	1.2	1.7	3.3	1.8	-0.9	0.9
Medication: Blood pressure	0.9	1.7	2.2	-1.4	-1.0	1.5
Angina (self-reported)	0.2	0.3	0.4	0.4	-0.6	-0.4
Migraine (self-reported)	1.8	2.3	4.0	-1.2	-1.1	2.0
Medication: Ibuprofen	1.2	1.5	2.6	-0.5	-1.6	1.2
Medication: Allopurinol	0.2	0.3	0.5	0.1	-0.7	0.7
Medication: Omeprazole	1.0	1.2	1.5	-1.0	-1.2	1.0
Medication: Seretide 50 evohaler	2.8	3.2	7.6	-1.3	-0.6	-2.7
Mean time to correctly identify matches	1.5	2.8	6.8	1.2	-0.5	-2.6
Heart disease (mother)	1.1	1.3	3.2	0.1	-1.8	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.2	-1.1	0.8	-0.5
Whole body fat mass	2.2	9.0	22.5	2.1	-4.7	-0.0
Leg fat mass (right)	2.0	7.6	21.0	1.1	-4.6	0.8
Arm predicted mass (right)	4.5	23.1	49.4	3.3	-7.0	-3.1
Pulse rate, automated reading	0.9	2.8	7.1	-1.1	-2.7	-0.3
Alcohol intake frequency.	0.5	1.3	2.0	1.4	-0.8	1.1
Comparative height size at age 10	6.7	37.0	47.2	5.2	-6.9	-6.1
Number of full sisters	0.6	0.7	0.8	-0.9	-0.9	-0.7
Suffer from ‘nerves’	1.5	2.4	5.3	-1.3	-2.3	0.6
Overall health rating	1.4	3.0	8.4	0.5	-2.9	0.7
Chest pain or discomfort	0.5	0.7	1.9	0.4	-1.4	0.2
Had major operations	2.3	2.7	5.1	1.8	-0.1	-2.2
Age at last live birth	0.4	0.6	1.6	-0.5	1.3	0.3
Family relationship satisfaction	2.0	2.5	4.5	0.1	-2.1	-1.7
Leg pain on walking	1.2	1.5	3.3	1.0	0.2	1.8
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	0.1	0.6	0.4
Commuting to job workplace: Car/motor vehicle	1.3	1.5	3.1	-0.9	0.8	1.8
Illness, injury, bereavement, stress in last 2 years	1.6	1.9	3.8	1.2	2.0	-0.7
Medication: Aspirin	0.7	0.9	2.6	-0.4	-1.6	-0.3
Supplements: Vitamin C	1.2	1.4	2.7	-0.1	1.2	-1.6
Knee pain experienced in last month	0.1	0.2	0.3	0.1	-0.5	0.5
Hypertension (Self-reported)	1.0	2.7	4.2	-1.5	-2.0	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.4	2.9	3.5	-1.6	-1.9	1.6
Illnesses of father: Heart disease	0.5	0.6	1.3	-0.8	-1.1	0.1
Illnesses of siblings: Diabetes	0.1	0.2	0.4	0.6	-0.1	0.3
Smoking status: Previous	1.6	2.4	4.0	-1.8	-2.0	0.4
Forced expiratory volume in 1-second (FEV1), predicted	2.5	5.2	8.6	2.0	-2.9	-1.8
Whole body fat-free mass	4.0	22.7	48.2	2.5	-6.9	-3.7
Leg fat-free mass (right)	2.6	13.7	30.0	1.5	-5.5	-3.0
Arm fat percentage (left)	0.4	1.7	4.1	-0.1	-2.0	1.0
Average weekly red wine intake	0.7	1.0	2.4	-0.5	1.5	-0.6
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.8	0.3	1.3	-0.4
Mood swings	0.3	0.5	1.3	-0.1	-1.1	-0.5
Loneliness, isolation	0.0	0.0	0.1	-0.0	-0.3	0.2
Long-standing illness, disability or infirmity	0.8	1.2	3.2	-0.1	-1.8	0.7
Ever had bowel cancer screening	1.0	1.1	2.6	-0.6	-1.6	-0.7
Diabetes diagnosed by doctor	0.7	1.2	3.4	0.3	-1.8	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	4.1	-2.0	-1.1	-0.0
Friendships satisfaction	1.1	1.4	3.0	0.7	-0.9	-1.7
Qualifications: nursing, teaching	0.1	0.1	0.2	0.4	0.2	-0.5
Commuting to job workplace: Walk	0.3	0.3	0.7	0.1	0.9	-0.3
Eye problems/disorders: Cataract	1.5	1.7	2.7	1.6	1.7	0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	0.0	-0.6	0.8
Medication for cholesterol	1.0	1.5	4.3	-0.1	2.1	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	2.0	-0.4	-1.3	-1.4
Back pain experienced in last month	1.6	2.3	3.8	1.9	-1.7	-0.5
Mineral and other dietary supplements	0.7	0.9	1.3	1.1	-0.6	1.0
Breast cancer (self-reported)	0.1	0.1	0.2	0.4	0.4	-0.2
Asthma (self-reported)	0.3	0.6	1.8	0.1	0.2	-1.3
Osteoporosis (self-reported)	1.6	2.0	3.4	-0.7	-1.4	-1.9
Osteoarthritis (self-reported)	0.6	0.8	1.5	1.2	-0.8	-0.6
Medication: Aspirin	0.6	0.8	2.2	-0.4	-1.5	-0.2
Medication: Gliclazide	0.8	0.9	1.2	0.8	-0.9	1.1
Illnesses of father: None of the above (group 1)	0.2	0.2	0.4	0.3	0.3	-0.7
Smoking status: Current	2.8	4.4	7.9	-2.8	-2.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.4	-0.5	1.5	0.4
Whole body water mass	3.9	22.2	46.6	2.5	-6.8	-3.7
Leg predicted mass (right)	2.6	13.8	30.1	1.4	-5.5	-3.0
Arm fat mass (left)	1.3	5.3	14.7	1.1	-3.8	-0.3
Number of self-reported non-cancer illnesses	0.6	1.1	2.2	-0.4	-1.5	1.0
Average weekly champagne plus white wine intake	1.5	2.0	4.3	-2.1	-1.2	0.4
Miserableness	0.7	1.3	2.3	-1.5	-0.9	0.9
Guilty feelings	4.6	6.9	11.5	-2.8	-3.4	-1.1
Wears glasses or contact lenses	1.0	1.1	1.9	-1.4	-0.8	-0.9
Ever taken oral contraceptive pill	0.8	0.9	1.8	1.3	1.0	0.2
Hearing aid user	0.7	0.8	1.4	1.2	0.9	-0.2
Mother’s age at death	0.7	0.9	1.9	1.4	0.8	0.4
Financial situation satisfaction	0.5	0.6	1.4	0.2	-1.2	0.6
Tinnitus: Yes, now most or all of the time	1.7	1.9	3.9	-0.3	-1.3	-2.0
Commuting to job workplace: Public transport	1.4	1.7	4.0	1.0	-0.2	-2.0
Eye problems/disorders: Glaucoma	1.6	1.9	4.6	2.2	-1.0	0.2
Medication: Blood pressure	0.5	1.0	2.4	0.5	-1.6	0.6
Pain type(s) experienced in last month: Hip pain	1.0	1.3	3.7	0.1	-1.9	0.4
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.6	-1.3	0.3	-0.3
High cholesterol (Self-reported)	1.3	2.3	4.8	-0.8	-1.2	-2.2
Medication: Bendroflumethiazide	1.1	1.6	2.8	-1.7	-0.6	1.3
Medication: Paracetamol	2.9	4.5	7.1	-2.2	-2.7	-1.2
Medication: Lisinopril	0.4	0.5	1.3	0.1	-0.2	1.1
Medication: Atorvastatin	1.4	1.7	2.5	-0.7	-1.6	1.4
Illnesses of father: High blood pressure	0.4	0.5	0.8	0.2	-0.9	0.7
Alcohol drinker status: Never	0.6	0.7	1.4	0.8	-0.3	1.2
Ever smoked	3.3	5.9	12.5	-3.5	-2.1	0.7
Basal metabolic rate	3.9	21.7	47.3	2.5	-6.9	-3.4
Leg fat percentage (left)	1.4	5.1	10.1	0.7	-3.2	2.2
Arm fat-free mass (left)	4.8	24.5	55.1	2.9	-7.4	-3.2
Number of operations (self-reported)	0.9	1.4	3.6	-0.6	-1.9	-0.2
Average weekly beer plus cider intake	0.3	0.4	1.0	-0.2	-1.0	0.3
Irritability	0.2	0.3	0.5	-0.7	-0.5	-0.3
Risk taking	0.6	0.8	1.4	-1.2	-0.5	0.9
Ever had prostate specific antigen (PSA) test	0.0	0.1	0.1	-0.0	-0.2	-0.3
Fractured/broken bones in last 5 years	0.9	1.1	2.9	-0.5	-1.7	-0.5
Age started oral contraceptive pill	0.4	0.6	0.8	0.7	0.9	-0.7
Diastolic blood pressure, automated reading	1.0	3.2	9.5	-0.1	-3.1	0.2
Ever depressed for a whole week	0.1	0.1	0.2	0.4	-0.5	0.2
Unable to work because of sickness or disability	1.2	1.6	4.1	0.7	-2.0	0.4
Commuting to job workplace: Cycle	0.7	0.8	1.3	-1.1	0.7	0.8
Myopia	1.7	2.5	4.0	-1.8	-2.0	0.4
Vascular/heart problems diagnosed by doctor	0.4	1.2	1.8	1.1	1.3	-0.6
Cholesterol lowering medication	2.3	3.4	7.5	0.5	-1.5	-2.7
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.5	-0.8	-0.4	1.6
Pain experienced in last month	1.4	2.3	4.5	-0.2	1.6	-2.1
Supplements: Calcium	1.0	1.1	1.4	-0.7	-1.2	-1.2
Basal cell carcinoma (self-reported)	1.4	1.7	3.8	0.0	1.9	-1.1
Heart attack/myocardial infarction (self-reported)	0.5	0.7	0.9	-0.5	-1.0	0.9
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.4	-0.5	-1.2	-0.6
Heart disease (siblings)	1.3	1.6	3.0	0.9	-1.7	-0.9
Alcohol drinker status: Previous	0.6	0.7	1.9	0.3	-1.4	-0.3
Pack years of smoking	0.9	1.4	3.4	1.8	-0.3	0.8
Impedance of whole body	0.8	4.1	6.5	2.5	2.4	0.1
Leg fat mass (left)	2.1	8.2	22.6	1.2	-4.8	0.8
Arm predicted mass (left)	4.4	22.3	48.8	2.8	-7.0	-3.2