Hub : Genes

CABLES1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 ROSMAP Brain Pre-frontal Cortex 0.1055 0.0356 9.1e-06 0.050 0.049 0.068 0.052 0.061 4.3e-07 6.2e-07 4.1e-09 2.7e-07 2.6e-08
2 TCGA Brain Lower Grade Glioma 0.0576 0.0264 1.8e-03 0.021 0.030 0.035 NA 0.033 1.6e-03 2.1e-04 6.8e-05 NA 9.7e-05
3 TCGA Prostate Adenocarcinoma 0.1000 0.0420 8.5e-03 -0.003 0.001 0.012 NA 0.001 9.6e-01 2.3e-01 2.0e-02 NA 2.6e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.7 1.1 3.0 -1.7 0.3 0.4
Bipolar Disorder or Schizophrenia 0.7 1.6 2.7 -1.6 -1.2 -0.9
Depressed Affect (Nagel 2018) 0.3 0.6 0.8 -0.8 -0.5 0.9
Depression (Nagel 2018) 1.0 1.5 2.0 -1.4 -1.2 0.9
Intelligence (Savage-Jansen 2018) 0.9 2.7 3.7 -1.9 1.9 -0.8
Neuroticism (Nagel 2018) 1.6 3.7 8.0 -1.6 -2.8 0.7
Schizophrenia (2018) 1.1 2.2 3.3 -0.6 -1.8 -1.7
Schizophrenia vs Biploar Disorder 5.2 6.9 17.9 4.2 -0.8 -1.4
Worry (Nagel 2018) 2.4 5.0 14.6 -0.7 -3.8 0.1
Alzheimer’s Disease (in mother) 1.0 1.1 2.8 0.5 0.6 1.7
Alzheimer’s Disease (in father) 0.3 0.3 0.6 -0.4 -0.8 -0.3
Alzheimer’s Disease (including proxy) 0.5 0.7 2.0 -0.1 0.4 1.4
Crohns Disease (2017) 0.2 0.4 0.9 -0.4 -1.0 0.4
Irritable Bowel Disease (IBD) 0.1 0.3 0.9 0.2 -1.0 -0.3
Ulcerative Colitis (UC) 0.2 0.3 0.6 0.3 -0.5 -0.8
Major Depression (MDD) 0.8 0.9 1.7 0.3 1.3 1.0
Reaction Time 1.0 1.9 5.5 0.6 -0.2 -2.3
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.4 -0.4 1.2 -0.3
Breast Cancer 0.4 1.0 1.9 1.4 -0.0 1.0
Ovarian Cancer 1.0 1.4 3.9 -2.0 -0.4 0.1
Prostate Cancer 0.6 0.8 1.5 -0.3 -1.2 -0.8
Age at First Birth 0.5 0.7 1.7 0.5 1.3 0.4
Bipolar Disorder (2011) 4.2 4.1 12.2 -3.5 0.4 0.0
Body Mass Index (BMI) (2010) 0.3 0.4 1.2 -0.0 -0.1 1.1
Coronary Artery Disease (CAD) 0.6 0.8 1.5 -1.2 -0.8 -0.5
Crohns Disease (2012) 0.1 0.2 0.4 -0.4 -0.6 -0.4
Mean Putamen Volume 1.3 1.4 3.9 -0.5 -0.5 2.0
Fasting Glucose 0.3 0.4 0.5 0.7 -0.4 0.6
HbA1C 0.5 0.6 1.6 0.0 -1.3 0.2
HDL Cholesterol 3.7 6.1 13.8 0.4 3.7 -2.1
LDL Cholesterol 0.5 0.7 1.5 0.5 -0.6 1.2
Lupus 0.6 1.0 2.0 0.9 -0.3 1.4
Neuroticism (2016) 0.3 0.4 1.1 -0.2 -1.1 0.3
Primary Biliary Cirrhosis 0.3 0.4 0.6 0.6 -0.5 -0.8
Rheumatoid Arthritis 1.6 2.2 4.4 2.1 -1.0 1.1
Schizophrenia (2014) 0.8 1.7 4.2 -0.3 -0.9 -2.0
Triglycerides 0.9 1.4 3.1 0.9 -0.5 1.8
Type 2 Diabetes (T2D) (2012) 1.0 1.1 1.8 -0.4 -1.3 1.2
Ulcerative Colitis 1.0 1.4 4.0 -0.6 -0.1 -2.0
Blood Eosinophil Count 0.4 2.8 6.2 0.0 -2.5 1.5
Blood Platelet Count 2.8 32.8 88.8 -2.9 -1.1 9.4
Blood Red Count 0.0 0.3 0.6 0.2 -0.8 0.6
Blood White Count 0.6 4.7 9.9 -1.9 -0.8 3.1
Heel T-Score 0.6 5.1 8.0 -2.8 2.5 1.0
BMI 1.0 6.0 10.9 -1.3 -3.3 2.3
Height 5.1 98.2 136.9 8.1 -11.7 -9.6
Waist Hip Ratio (WHR) 2.1 9.5 24.8 1.8 -5.0 -0.6
Systolic Blood Pressure 0.1 0.7 1.2 0.3 -1.1 0.8
Smoking Status 2.8 6.8 11.0 -3.3 -3.0 0.8
Allergy or Eczema 0.0 0.1 0.1 -0.2 -0.1 0.3
Cardiovascular Disease 0.3 1.1 2.5 0.1 -1.6 0.9
Hypothyroidism (self reported) 1.8 4.2 8.4 -0.7 -2.9 -1.9
Respiratory disease 0.4 0.9 1.9 1.4 0.1 -0.9
Type 2 Diabetes (T2D) (2018) 0.8 1.4 3.0 -0.2 -1.7 1.1
Lung FEV1/FVC ratio 0.0 0.2 0.3 0.5 0.5 0.3
Lung FVC 1.4 6.9 10.0 -1.7 3.2 2.8
Neuroticism 1.0 2.5 5.9 -0.4 -2.4 1.2
Chronotype (morning person) 0.1 0.2 0.5 0.2 0.7 0.2
Hair Pigment 0.0 0.5 0.6 0.8 0.7 0.6
Tanning 0.3 4.2 6.7 -2.4 -0.5 -2.6
Hand grip strength (left) 1.6 4.1 7.5 1.9 -2.7 -1.1
Number of treatments/medications taken 1.5 2.7 6.2 -1.4 -2.5 0.0
Average weekly spirits intake 0.7 0.8 1.9 -0.6 -0.4 -1.4
Sensitivity / hurt feelings 0.7 1.3 1.6 -1.0 -1.3 1.1
Frequency of depressed mood in last 2 weeks 2.8 3.9 6.1 -1.8 -2.5 1.5
Hearing difficulty/problems: Yes 2.3 3.6 7.7 0.2 -2.8 -1.7
Relative age of first facial hair 1.7 3.5 5.4 1.1 2.3 2.0
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.6 0.4 -1.3 0.2
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.7 -0.7 -0.9 -0.1
Ever had hysterectomy (womb removed) 0.7 0.8 1.4 0.1 -1.0 1.2
Systolic blood pressure, automated reading 0.2 0.5 0.7 -0.7 -0.8 0.5
Eye problems/disorders: Diabetes related eye disease 1.5 1.7 2.2 1.5 -1.2 -1.2
Angina 0.2 0.3 0.4 0.4 -0.6 -0.6
Medication for hormone replacement therapy 1.5 1.7 3.8 -0.6 -1.9 0.9
Vitamin and mineral supplements 1.0 1.3 3.1 0.7 0.7 1.7
Supplements: Zinc 0.5 0.5 1.4 0.1 1.2 -0.4
Medication: Co-codamol 2.0 2.3 6.4 -0.3 -2.5 -0.7
Medication: Metformin 1.4 2.0 4.4 -0.7 -2.1 1.0
Diabetes (father) 0.3 0.4 0.9 0.0 0.5 1.0
Diabetes (mother) 1.4 1.7 3.8 0.7 -1.9 -0.9
Severe depression (siblings) 0.5 0.5 1.5 0.2 -1.2 -0.1
Pack years adult smoking proportion 0.7 1.0 2.3 1.5 -0.4 0.8
Impedance of leg (right) 0.4 2.0 5.7 2.4 0.4 0.4
Leg fat-free mass (left) 2.6 13.8 30.4 1.5 -5.5 -3.0
Trunk fat percentage 1.0 3.8 6.6 2.2 -2.6 0.3
Hand grip strength (right) 1.2 3.3 7.5 1.1 -2.7 -1.1
Townsend deprivation index at recruitment 0.2 0.3 0.7 0.3 -0.8 -0.5
Current tobacco smoking 2.7 4.5 8.2 -2.9 -2.3 -0.3
Average weekly fortified wine intake 0.7 0.8 2.3 0.2 1.5 0.0
Maternal smoking around birth 0.2 0.3 0.6 -0.4 0.5 0.7
Fed-up feelings 1.0 1.8 2.2 -1.4 -1.1 1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.0 4.1 -1.2 -2.0 0.8
Relative age voice broke 0.9 1.4 3.7 -0.7 0.2 1.9
Taking other prescription medications 1.7 2.6 5.7 -1.2 -2.4 0.8
Age when periods started (menarche) 0.1 0.3 0.5 -0.7 0.1 -0.6
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.0 0.8 -1.4 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 1.5 0.2 -1.2 -0.0
Tinnitus: Yes, but not now, but have in the past 1.0 1.1 2.4 0.6 -1.6 0.6
Qualifications: CSEs or equivalent 0.8 1.1 3.0 1.7 -0.3 0.4
Serious illness, injury or assault to yourself 2.9 3.5 9.7 0.9 -3.1 0.0
High blood pressure 1.2 3.4 6.0 -1.7 -2.4 1.1
Hayfever, allergic rhinitis or eczema 0.4 0.8 1.8 -0.6 -0.5 1.3
Multivitamins +/- minerals 0.6 0.7 1.9 -0.5 -1.4 -0.3
Stomach or abdominal pain in last month 0.7 0.9 1.6 1.3 -1.0 0.4
Supplements: Glucosamine 0.7 0.9 2.3 0.3 1.5 0.5
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 0.4 -0.1 -0.7 -0.6
Medication: Atenolol 1.4 1.8 2.4 1.3 1.5 -1.1
Medication: Levothyroxine sodium 2.3 3.9 7.3 -0.2 -2.7 -2.1
Sitting height 0.8 5.8 9.4 1.6 -3.1 -2.3
Chronic bronchitis/emphysema (father) 2.5 3.0 5.9 2.4 -0.7 -1.6
High blood pressure (mother) 0.3 0.4 0.5 -0.7 -0.4 0.7
Body mass index (BMI) 0.7 3.1 8.0 -0.4 -2.8 1.1
Impedance of leg (left) 0.6 2.9 8.3 2.9 0.1 0.6
Leg predicted mass (left) 2.6 13.9 30.5 1.5 -5.5 -3.0
Trunk fat mass 2.0 8.5 18.5 2.6 -4.3 -0.5
Waist circumference 3.7 13.6 36.8 1.9 -6.1 -0.7
Number of incorrect matches in round 0.7 1.1 1.8 1.2 -1.3 0.4
Past tobacco smoking 2.7 5.0 8.6 2.9 2.5 -0.6
Alcohol usually taken with meals 0.1 0.2 0.6 0.3 0.7 -0.0
Nervous feelings 2.2 4.2 11.3 -1.1 -3.4 -0.2
Frequency of tenseness / restlessness in last 2 weeks 2.0 3.1 7.5 -0.7 -2.7 -1.1
Hearing difficulty/problems with background noise 1.4 2.3 6.3 -0.2 -2.5 -0.7
Hair/balding pattern: Pattern 2 0.1 0.1 0.2 0.4 -0.4 0.0
Had menopause 0.9 1.2 2.3 1.5 -0.9 -0.6
Had other major operations 0.3 0.4 1.0 0.0 -0.4 1.0
Forced vital capacity (FVC) 0.1 0.2 0.4 0.1 -0.6 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.1 0.3 -0.0 -0.5 -0.1
Ever unenthusiastic/disinterested for a whole week 0.1 0.2 0.4 0.0 -0.4 0.6
Qualifications: None of the above 0.3 0.7 1.4 0.8 -0.3 1.2
Financial difficulties in last 2 years 1.4 1.9 3.5 -0.9 -1.9 1.2
Mouth/teeth dental problems 1.4 2.2 6.3 -0.4 2.5 -0.3
Heart attack 0.6 0.8 1.1 -0.3 -1.1 1.0
Allergy 0.1 0.3 0.5 0.3 0.4 -0.7
Pain all over the body in last month 2.3 2.5 5.6 -0.6 -2.4 1.2
Diabetes (self-reported) 0.7 1.1 3.3 0.1 -1.8 -0.2
Hayfever/allergic rhinitis (self-reported) 1.7 2.3 3.8 1.6 0.6 1.9
Medication: Ramipril 0.4 0.5 0.7 -0.9 -0.1 0.8
Medication: Simvastatin 1.1 1.6 4.0 -0.9 -0.1 -2.0
Fluid intelligence score 0.1 0.2 0.3 -0.6 0.1 -0.4
Illnesses of siblings 0.4 0.6 0.9 -0.9 0.9 -0.1
Neuroticism score 2.2 4.6 11.0 -1.7 -3.3 -0.1
Weight 2.9 14.4 32.8 2.7 -5.7 -1.7
Impedance of arm (right) 0.9 4.3 11.1 1.2 3.3 -0.5
Arm fat percentage (right) 0.5 1.9 4.4 -0.2 -2.1 1.1
Trunk fat-free mass 4.4 25.5 51.1 3.0 -7.2 -4.1
Hip circumference 1.5 6.7 14.9 2.2 -3.9 -0.2
Time employed in main current job 2.0 2.3 3.9 2.0 -0.7 -1.6
Alcohol intake versus 10 years previously 0.3 0.5 1.0 -1.0 -0.3 0.6
Father’s age at death 1.0 1.4 3.2 0.5 1.8 0.8
Worrier / anxious feelings 2.7 5.0 13.2 -1.4 -3.6 -0.1
Frequency of tiredness / lethargy in last 2 weeks 2.5 4.1 6.5 -2.6 -2.2 1.0
Falls in the last year 3.4 4.6 9.8 0.5 -3.1 -2.0
Hair/balding pattern: Pattern 3 1.0 1.6 4.1 0.8 -0.2 -2.0
Number of live births 0.2 0.3 0.5 -0.7 0.0 0.6
Forced expiratory volume in 1-second (FEV1) 0.0 0.1 0.2 0.4 -0.1 -0.1
Pulse rate 0.2 0.3 0.8 -0.4 0.9 0.3
Happiness 0.9 1.1 2.1 -0.5 -1.5 -0.9
Noisy workplace 1.1 1.3 2.4 0.9 1.5 -0.9
Qualifications: A levels/AS levels or equivalent 1.5 3.3 7.9 -2.8 1.4 -0.4
Serious illness, injury or assault of a close relative in last 2 years 2.6 3.0 8.8 -0.5 -3.0 -0.2
Mouth/teeth dental problems: Dentures 0.8 1.4 3.2 -0.6 -1.8 -0.7
Asthma 0.3 0.5 1.3 -0.3 0.2 -1.1
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.8 1.1 -0.5 -1.0 1.1
Medication: Cholesterol lowering 0.5 0.7 1.2 -0.7 1.1 0.7
Depression (self-reported) 0.4 0.5 1.5 -1.2 -0.3 -0.0
Medication: Lansoprazole 0.8 0.9 1.2 -0.6 -1.0 1.1
Prospective memory result 0.9 1.1 2.3 1.5 0.1 1.0
Lung cancer (father) 4.4 5.1 9.8 1.8 1.5 3.1
Illnesses of mother 0.1 0.1 0.3 -0.6 -0.1 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 0.4 0.7 -0.6 0.1
Pulse wave Arterial Stiffness index 0.4 0.5 0.6 -0.8 -0.4 0.8
Impedance of arm (left) 1.1 5.2 12.3 1.7 3.5 -0.6
Arm fat mass (right) 1.4 5.8 16.4 1.1 -4.0 -0.1
Trunk predicted mass 4.4 25.2 50.6 3.0 -7.1 -4.0
Standing height 4.8 47.6 53.4 7.3 -6.9 -6.5
Length of working week for main job 0.5 0.5 0.7 0.5 -0.8 0.8
Exposure to tobacco smoke at home 0.4 0.5 1.4 -0.2 0.0 1.2
Breastfed as a baby 0.3 0.4 0.4 -0.7 0.5 -0.6
Tense / ‘highly strung’ 0.6 1.0 1.4 1.2 -1.2 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 0.5 -0.4 -0.7 -0.7
Hair/balding pattern: Pattern 4 0.3 0.7 1.5 -1.2 0.6 0.6
Birth weight of first child 0.6 1.1 2.8 0.0 1.7 -0.6
Peak expiratory flow (PEF) 0.1 0.2 0.7 -0.8 -0.2 0.1
Pulse wave reflection index 0.6 0.7 2.2 -1.5 0.3 0.1
Ever highly irritable/argumentative for 2 days 1.7 2.1 3.6 -0.1 -1.6 -1.9
Loud music exposure frequency 0.6 0.6 1.0 -0.2 -1.0 -0.9
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 1.5 -1.2 0.1 1.2
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.7 -0.7 -1.3 0.5
Blood clot in the leg (DVT) 0.3 0.4 1.0 -0.3 -1.0 -0.3
Medication: Paracetamol 1.8 2.9 5.1 -1.8 -2.3 -0.6
Headache pain in last month 0.0 0.0 0.1 -0.1 -0.0 0.3
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 2.8 0.3 -0.9 -1.7
Glaucoma (self-reported) 2.7 3.1 4.8 2.2 -1.0 1.9
Gout (self-reported) 0.5 0.7 1.7 0.4 -1.3 -0.4
Hypothyroidism/myxoedema (self-reported) 2.3 4.4 6.2 -1.3 -2.5 -2.3
Medication: Amlodipine 1.2 1.7 4.0 -1.1 -2.0 0.2
Medication: Ventolin 100micrograms inhaler 0.3 0.3 0.5 0.7 -0.7 0.3
Birth weight 1.5 3.2 4.8 2.1 -0.6 -2.2
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.4 -0.7 0.0 0.4
High blood pressure (siblings) 0.1 0.2 0.3 0.1 -0.5 0.5
Forced vital capacity (FVC), Best measure 0.2 0.6 1.3 0.4 -1.1 -0.5
Body fat percentage 1.0 4.0 8.3 1.6 -2.9 1.0
Leg fat percentage (right) 1.3 4.8 9.2 0.6 -3.0 2.2
Arm fat-free mass (right) 4.6 23.6 51.1 3.1 -7.2 -3.2
Exposure to tobacco smoke outside home 0.8 1.0 1.7 -0.2 -1.3 1.2
Comparative body size at age 10 0.1 0.3 0.6 -0.4 -0.4 0.7
Number of full brothers 1.2 1.5 3.4 0.9 -1.8 0.6
Worry too long after embarrassment 4.3 7.3 16.2 -2.4 -4.0 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.4 0.7 0.3 -0.6
Wheeze or whistling in the chest in last year 0.7 1.2 1.7 0.9 -1.1 -1.3
Number of children fathered 0.7 0.8 2.3 -1.5 -0.5 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.2 -0.5 -0.1 0.3
Age at first live birth 0.2 0.3 0.6 -0.5 0.1 -0.7
Pulse wave peak to peak time 1.1 1.3 2.2 1.3 -0.1 -1.5
Health satisfaction 0.2 0.3 0.9 -0.2 0.1 0.9
Shortness of breath walking on level ground 1.6 1.9 3.9 2.0 -0.2 1.3
Qualifications: College or University degree 0.7 2.3 4.5 -2.1 0.1 -1.5
Eye problems/disorders: None of the above 0.6 0.7 1.0 -0.8 -0.6 -1.0
Mouth/teeth dental problems: Loose teeth 0.8 1.0 2.6 0.5 -1.6 -0.1
Emphysema/chronic bronchitis 0.1 0.1 0.4 0.6 -0.0 0.1
Medication for pain relief, constipation, heartburn 0.9 1.6 4.2 0.7 2.1 -0.1
Neck or shoulder pain in last month 1.2 1.7 3.3 1.8 -0.9 0.9
Medication: Blood pressure 0.9 1.7 2.2 -1.4 -1.0 1.5
Angina (self-reported) 0.2 0.3 0.4 0.4 -0.6 -0.4
Migraine (self-reported) 1.8 2.3 4.0 -1.2 -1.1 2.0
Medication: Ibuprofen 1.2 1.5 2.6 -0.5 -1.6 1.2
Medication: Allopurinol 0.2 0.3 0.5 0.1 -0.7 0.7
Medication: Omeprazole 1.0 1.2 1.5 -1.0 -1.2 1.0
Medication: Seretide 50 evohaler 2.8 3.2 7.6 -1.3 -0.6 -2.7
Mean time to correctly identify matches 1.5 2.8 6.8 1.2 -0.5 -2.6
Heart disease (mother) 1.1 1.3 3.2 0.1 -1.8 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.2 -1.1 0.8 -0.5
Whole body fat mass 2.2 9.0 22.5 2.1 -4.7 -0.0
Leg fat mass (right) 2.0 7.6 21.0 1.1 -4.6 0.8
Arm predicted mass (right) 4.5 23.1 49.4 3.3 -7.0 -3.1
Pulse rate, automated reading 0.9 2.8 7.1 -1.1 -2.7 -0.3
Alcohol intake frequency. 0.5 1.3 2.0 1.4 -0.8 1.1
Comparative height size at age 10 6.7 37.0 47.2 5.2 -6.9 -6.1
Number of full sisters 0.6 0.7 0.8 -0.9 -0.9 -0.7
Suffer from ‘nerves’ 1.5 2.4 5.3 -1.3 -2.3 0.6
Overall health rating 1.4 3.0 8.4 0.5 -2.9 0.7
Chest pain or discomfort 0.5 0.7 1.9 0.4 -1.4 0.2
Had major operations 2.3 2.7 5.1 1.8 -0.1 -2.2
Age at last live birth 0.4 0.6 1.6 -0.5 1.3 0.3
Family relationship satisfaction 2.0 2.5 4.5 0.1 -2.1 -1.7
Leg pain on walking 1.2 1.5 3.3 1.0 0.2 1.8
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.4 0.1 0.6 0.4
Commuting to job workplace: Car/motor vehicle 1.3 1.5 3.1 -0.9 0.8 1.8
Illness, injury, bereavement, stress in last 2 years 1.6 1.9 3.8 1.2 2.0 -0.7
Medication: Aspirin 0.7 0.9 2.6 -0.4 -1.6 -0.3
Supplements: Vitamin C 1.2 1.4 2.7 -0.1 1.2 -1.6
Knee pain experienced in last month 0.1 0.2 0.3 0.1 -0.5 0.5
Hypertension (Self-reported) 1.0 2.7 4.2 -1.5 -2.0 1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.4 2.9 3.5 -1.6 -1.9 1.6
Illnesses of father: Heart disease 0.5 0.6 1.3 -0.8 -1.1 0.1
Illnesses of siblings: Diabetes 0.1 0.2 0.4 0.6 -0.1 0.3
Smoking status: Previous 1.6 2.4 4.0 -1.8 -2.0 0.4
Forced expiratory volume in 1-second (FEV1), predicted 2.5 5.2 8.6 2.0 -2.9 -1.8
Whole body fat-free mass 4.0 22.7 48.2 2.5 -6.9 -3.7
Leg fat-free mass (right) 2.6 13.7 30.0 1.5 -5.5 -3.0
Arm fat percentage (left) 0.4 1.7 4.1 -0.1 -2.0 1.0
Average weekly red wine intake 0.7 1.0 2.4 -0.5 1.5 -0.6
Handedness (chirality/laterality): Left-handed 0.6 0.7 1.8 0.3 1.3 -0.4
Mood swings 0.3 0.5 1.3 -0.1 -1.1 -0.5
Loneliness, isolation 0.0 0.0 0.1 -0.0 -0.3 0.2
Long-standing illness, disability or infirmity 0.8 1.2 3.2 -0.1 -1.8 0.7
Ever had bowel cancer screening 1.0 1.1 2.6 -0.6 -1.6 -0.7
Diabetes diagnosed by doctor 0.7 1.2 3.4 0.3 -1.8 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 1.7 1.8 4.1 -2.0 -1.1 -0.0
Friendships satisfaction 1.1 1.4 3.0 0.7 -0.9 -1.7
Qualifications: nursing, teaching 0.1 0.1 0.2 0.4 0.2 -0.5
Commuting to job workplace: Walk 0.3 0.3 0.7 0.1 0.9 -0.3
Eye problems/disorders: Cataract 1.5 1.7 2.7 1.6 1.7 0.1
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.6 0.0 -0.6 0.8
Medication for cholesterol 1.0 1.5 4.3 -0.1 2.1 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 2.0 -0.4 -1.3 -1.4
Back pain experienced in last month 1.6 2.3 3.8 1.9 -1.7 -0.5
Mineral and other dietary supplements 0.7 0.9 1.3 1.1 -0.6 1.0
Breast cancer (self-reported) 0.1 0.1 0.2 0.4 0.4 -0.2
Asthma (self-reported) 0.3 0.6 1.8 0.1 0.2 -1.3
Osteoporosis (self-reported) 1.6 2.0 3.4 -0.7 -1.4 -1.9
Osteoarthritis (self-reported) 0.6 0.8 1.5 1.2 -0.8 -0.6
Medication: Aspirin 0.6 0.8 2.2 -0.4 -1.5 -0.2
Medication: Gliclazide 0.8 0.9 1.2 0.8 -0.9 1.1
Illnesses of father: None of the above (group 1) 0.2 0.2 0.4 0.3 0.3 -0.7
Smoking status: Current 2.8 4.4 7.9 -2.8 -2.3 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 2.4 -0.5 1.5 0.4
Whole body water mass 3.9 22.2 46.6 2.5 -6.8 -3.7
Leg predicted mass (right) 2.6 13.8 30.1 1.4 -5.5 -3.0
Arm fat mass (left) 1.3 5.3 14.7 1.1 -3.8 -0.3
Number of self-reported non-cancer illnesses 0.6 1.1 2.2 -0.4 -1.5 1.0
Average weekly champagne plus white wine intake 1.5 2.0 4.3 -2.1 -1.2 0.4
Miserableness 0.7 1.3 2.3 -1.5 -0.9 0.9
Guilty feelings 4.6 6.9 11.5 -2.8 -3.4 -1.1
Wears glasses or contact lenses 1.0 1.1 1.9 -1.4 -0.8 -0.9
Ever taken oral contraceptive pill 0.8 0.9 1.8 1.3 1.0 0.2
Hearing aid user 0.7 0.8 1.4 1.2 0.9 -0.2
Mother’s age at death 0.7 0.9 1.9 1.4 0.8 0.4
Financial situation satisfaction 0.5 0.6 1.4 0.2 -1.2 0.6
Tinnitus: Yes, now most or all of the time 1.7 1.9 3.9 -0.3 -1.3 -2.0
Commuting to job workplace: Public transport 1.4 1.7 4.0 1.0 -0.2 -2.0
Eye problems/disorders: Glaucoma 1.6 1.9 4.6 2.2 -1.0 0.2
Medication: Blood pressure 0.5 1.0 2.4 0.5 -1.6 0.6
Pain type(s) experienced in last month: Hip pain 1.0 1.3 3.7 0.1 -1.9 0.4
Supplements: Fish oil (including cod liver oil) 0.5 0.6 1.6 -1.3 0.3 -0.3
High cholesterol (Self-reported) 1.3 2.3 4.8 -0.8 -1.2 -2.2
Medication: Bendroflumethiazide 1.1 1.6 2.8 -1.7 -0.6 1.3
Medication: Paracetamol 2.9 4.5 7.1 -2.2 -2.7 -1.2
Medication: Lisinopril 0.4 0.5 1.3 0.1 -0.2 1.1
Medication: Atorvastatin 1.4 1.7 2.5 -0.7 -1.6 1.4
Illnesses of father: High blood pressure 0.4 0.5 0.8 0.2 -0.9 0.7
Alcohol drinker status: Never 0.6 0.7 1.4 0.8 -0.3 1.2
Ever smoked 3.3 5.9 12.5 -3.5 -2.1 0.7
Basal metabolic rate 3.9 21.7 47.3 2.5 -6.9 -3.4
Leg fat percentage (left) 1.4 5.1 10.1 0.7 -3.2 2.2
Arm fat-free mass (left) 4.8 24.5 55.1 2.9 -7.4 -3.2
Number of operations (self-reported) 0.9 1.4 3.6 -0.6 -1.9 -0.2
Average weekly beer plus cider intake 0.3 0.4 1.0 -0.2 -1.0 0.3
Irritability 0.2 0.3 0.5 -0.7 -0.5 -0.3
Risk taking 0.6 0.8 1.4 -1.2 -0.5 0.9
Ever had prostate specific antigen (PSA) test 0.0 0.1 0.1 -0.0 -0.2 -0.3
Fractured/broken bones in last 5 years 0.9 1.1 2.9 -0.5 -1.7 -0.5
Age started oral contraceptive pill 0.4 0.6 0.8 0.7 0.9 -0.7
Diastolic blood pressure, automated reading 1.0 3.2 9.5 -0.1 -3.1 0.2
Ever depressed for a whole week 0.1 0.1 0.2 0.4 -0.5 0.2
Unable to work because of sickness or disability 1.2 1.6 4.1 0.7 -2.0 0.4
Commuting to job workplace: Cycle 0.7 0.8 1.3 -1.1 0.7 0.8
Myopia 1.7 2.5 4.0 -1.8 -2.0 0.4
Vascular/heart problems diagnosed by doctor 0.4 1.2 1.8 1.1 1.3 -0.6
Cholesterol lowering medication 2.3 3.4 7.5 0.5 -1.5 -2.7
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 2.5 -0.8 -0.4 1.6
Pain experienced in last month 1.4 2.3 4.5 -0.2 1.6 -2.1
Supplements: Calcium 1.0 1.1 1.4 -0.7 -1.2 -1.2
Basal cell carcinoma (self-reported) 1.4 1.7 3.8 0.0 1.9 -1.1
Heart attack/myocardial infarction (self-reported) 0.5 0.7 0.9 -0.5 -1.0 0.9
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.4 -0.5 -1.2 -0.6
Heart disease (siblings) 1.3 1.6 3.0 0.9 -1.7 -0.9
Alcohol drinker status: Previous 0.6 0.7 1.9 0.3 -1.4 -0.3
Pack years of smoking 0.9 1.4 3.4 1.8 -0.3 0.8
Impedance of whole body 0.8 4.1 6.5 2.5 2.4 0.1
Leg fat mass (left) 2.1 8.2 22.6 1.2 -4.8 0.8
Arm predicted mass (left) 4.4 22.3 48.8 2.8 -7.0 -3.2