[Hub]/) : Traits : Leg fat-free mass (right) :

chr19:18,333,894-20,451,172

Best TWAS P=5.28e-11 · Best GWAS P=6.36e-11 conditioned to 0.0141

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Brain Hippocampus DDX49 0.23 -0.01 lasso 4 -0.01 6.6e-01 -5.2 5.5 4.6e-08 -0.53 0.02 0.56 FALSE
2 GTEx Cells Transformed fibroblasts ATP13A1 0.14 0.06 lasso 5 0.05 2.2e-04 -5.4 -5.7 1.5e-08 0.89 0.04 0.90 FALSE
3 GTEx Cells Transformed fibroblasts GATAD2A 0.07 0.00 lasso 4 0.00 8.1e-01 -5.0 -6.6 5.3e-11 0.75 0.03 0.73 TRUE
4 GTEx Muscle Skeletal MAU2 0.09 0.04 lasso 4 0.05 5.1e-06 -5.4 5.9 4.8e-09 -0.52 0.70 0.30 FALSE
5 GTEx Whole Blood GATAD2A 0.06 0.02 lasso 9 0.03 1.7e-03 -5.3 -5.8 5.5e-09 0.56 0.45 0.41 FALSE
6 ROSMAP Brain Pre-frontal Cortex ATP13A1 0.10 0.07 lasso 5 0.06 1.3e-08 -5.9 5.9 3.4e-09 -0.82 0.06 0.94 FALSE
7 YFS Blood GATAD2A 0.09 0.14 blup 365 0.14 7.5e-44 -5.0 -5.2 2.4e-07 0.34 0.91 0.09 FALSE
8 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma HAPLN4 0.05 0.07 lasso 2 0.06 1.1e-07 -5.4 -5.7 9.2e-09 0.41 0.07 0.93 FALSE
9 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SF4 0.03 0.01 enet 7 0.02 1.1e-03 -5.0 -5.3 1.5e-07 0.31 0.10 0.63 FALSE
10 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TM6SF2 0.04 0.03 blup 35 0.03 2.5e-04 -5.4 -6.0 1.5e-09 0.66 0.06 0.84 FALSE
11 The Cancer Genome Atlas Brain Lower Grade Glioma KIAA0892 0.03 0.01 lasso 7 0.02 6.3e-03 -5.4 5.4 6.2e-08 -0.35 0.04 0.48 FALSE
12 The Cancer Genome Atlas Prostate Adenocarcinoma GATAD2A 0.04 0.03 lasso 2 0.03 2.9e-04 -4.9 -5.7 1.4e-08 0.45 0.05 0.87 FALSE
13 The Cancer Genome Atlas Thyroid Carcinoma KIAA0892 0.04 0.04 blup 43 0.02 4.1e-03 -5.4 5.4 5.5e-08 -0.36 0.08 0.85 FALSE
14 The Cancer Genome Atlas Thyroid Carcinoma TM6SF2 0.05 0.04 blup 34 0.05 2.8e-05 -5.4 -5.3 1.1e-07 0.61 0.06 0.90 FALSE