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chr19:18,333,894-20,451,172

Best TWAS P=5.28e-11 · Best GWAS P=6.36e-11 conditioned to 0.0141

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Cells Transformed fibroblasts	GATAD2A	0.07	0.00	lasso	4	0.00	8.1e-01	-5.0	-6.6	5.3e-11	0.75	0.03	0.73	TRUE
10	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TM6SF2	0.04	0.03	blup	35	0.03	2.5e-04	-5.4	-6.0	1.5e-09	0.66	0.06	0.84	FALSE
6	ROSMAP	Brain Pre-frontal Cortex	ATP13A1	0.10	0.07	lasso	5	0.06	1.3e-08	-5.9	5.9	3.4e-09	-0.82	0.06	0.94	FALSE
4	GTEx	Muscle Skeletal	MAU2	0.09	0.04	lasso	4	0.05	5.1e-06	-5.4	5.9	4.8e-09	-0.52	0.70	0.30	FALSE
5	GTEx	Whole Blood	GATAD2A	0.06	0.02	lasso	9	0.03	1.7e-03	-5.3	-5.8	5.5e-09	0.56	0.45	0.41	FALSE
8	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HAPLN4	0.05	0.07	lasso	2	0.06	1.1e-07	-5.4	-5.7	9.2e-09	0.41	0.07	0.93	FALSE
12	The Cancer Genome Atlas	Prostate Adenocarcinoma	GATAD2A	0.04	0.03	lasso	2	0.03	2.9e-04	-4.9	-5.7	1.4e-08	0.45	0.05	0.87	FALSE
2	GTEx	Cells Transformed fibroblasts	ATP13A1	0.14	0.06	lasso	5	0.05	2.2e-04	-5.4	-5.7	1.5e-08	0.89	0.04	0.90	FALSE
1	GTEx	Brain Hippocampus	DDX49	0.23	-0.01	lasso	4	-0.01	6.6e-01	-5.2	5.5	4.6e-08	-0.53	0.02	0.56	FALSE
13	The Cancer Genome Atlas	Thyroid Carcinoma	KIAA0892	0.04	0.04	blup	43	0.02	4.1e-03	-5.4	5.4	5.5e-08	-0.36	0.08	0.85	FALSE
11	The Cancer Genome Atlas	Brain Lower Grade Glioma	KIAA0892	0.03	0.01	lasso	7	0.02	6.3e-03	-5.4	5.4	6.2e-08	-0.35	0.04	0.48	FALSE
14	The Cancer Genome Atlas	Thyroid Carcinoma	TM6SF2	0.05	0.04	blup	34	0.05	2.8e-05	-5.4	-5.3	1.1e-07	0.61	0.06	0.90	FALSE
9	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SF4	0.03	0.01	enet	7	0.02	1.1e-03	-5.0	-5.3	1.5e-07	0.31	0.10	0.63	FALSE
7	YFS	Blood	GATAD2A	0.09	0.14	blup	365	0.14	7.5e-44	-5.0	-5.2	2.4e-07	0.34	0.91	0.09	FALSE