TWAS hub - TM6SF2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Clear Cell Carcinoma	0.038	0.0195	0.00061	0.034	0.030	0.022	NA	0.029	9.5e-05	2.5e-04	0.00150	NA	0.00031
2	TCGA	Thyroid Carcinoma	0.051	0.0290	0.00011	0.043	0.046	0.040	NA	0.038	4.9e-05	2.8e-05	0.00009	NA	0.00014

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Triglycerides	38.7	63.4	69.4	-8.3	-7.6
LDL Cholesterol	24.1	38.2	40.8	-6.4	-6.0
High cholesterol (Self-reported)	21.1	37.5	40.8	-6.4	-5.8
Illnesses of siblings: Diabetes	18.2	22.4	26.0	4.3	5.1
Medication: Cholesterol lowering	15.6	24.2	27.2	-5.2	-4.6
Medication: Atorvastatin	13.0	16.1	18.7	-4.3	-3.7
Type 2 Diabetes (T2D) (2018)	11.6	21.6	22.3	4.7	4.6
Diabetes (mother)	11.5	14.6	15.0	3.8	3.9
Age at first live birth	11.4	20.1	20.3	-4.5	-4.5
Maternal smoking around birth	11.0	16.0	18.5	3.7	4.3
Serious illness, injury or assault of a close relative in last 2 years	10.9	12.5	15.2	-3.9	-3.1
Diabetes diagnosed by doctor	10.8	17.7	19.4	4.0	4.4
Medication: Simvastatin	10.3	15.1	15.6	-4.0	-3.8
Standing height	10.2	101.4	110.2	-10.5	-9.6
Coronary Artery Disease (CAD)	9.9	11.8	11.8	-3.4	-3.4
Illnesses of father: Heart disease	9.7	13.5	13.8	-3.7	-3.6
Hair/balding pattern: Pattern 2	9.6	12.3	12.8	3.6	3.4
Qualifications: None of the above	9.2	19.7	20.9	4.6	4.3
Fasting Glucose	9.1	10.9	13.1	3.6	3.0
Eye problems/disorders: Diabetes related eye disease	9.1	10.0	11.9	2.9	3.4
Medication: Gliclazide	9.0	10.2	10.5	3.1	3.2
Leg fat percentage (left)	8.9	32.2	34.0	5.8	5.5
Leg fat percentage (right)	8.7	31.5	34.5	5.9	5.3
Taking other prescription medications	8.5	13.2	13.2	3.6	3.6
Comparative height size at age 10	8.0	44.0	46.3	-6.8	-6.5
Medication: Paracetamol	7.9	13.2	13.3	3.6	3.6
Number of live births	7.7	10.8	10.9	3.3	3.3
Qualifications: A levels/AS levels or equivalent	7.7	17.1	17.2	-4.1	-4.1
Diabetes (self-reported)	7.6	11.7	11.7	3.4	3.4
Birth weight of first child	7.2	13.0	15.0	-3.9	-3.3
Height	7.0	134.9	148.8	-12.2	-11.0
Diastolic blood pressure, automated reading	6.9	21.5	21.6	4.6	4.6
Pulse wave peak to peak time	6.7	7.9	8.2	-2.9	-2.7
Medication: Metformin	6.6	9.3	10.4	2.9	3.2
Loneliness, isolation	6.5	9.0	9.5	3.1	2.9
Number of treatments/medications taken	6.3	11.4	11.9	3.3	3.5
Medication: Lansoprazole	6.2	7.0	7.5	2.7	2.6
Overall health rating	6.2	13.2	15.4	3.9	3.3
Age at last live birth	6.2	9.0	10.4	-3.2	-2.7
Impedance of arm (right)	6.1	28.3	29.8	-5.2	-5.5
Forced vital capacity (FVC), Best measure	6.1	22.2	25.3	-5.0	-4.4
Leg fat-free mass (right)	6.1	32.4	36.5	-6.0	-5.3
Sensitivity / hurt feelings	6.0	10.3	12.1	3.5	2.9
Leg predicted mass (right)	6.0	32.3	36.4	-6.0	-5.3
Stomach or abdominal pain in last month	5.9	7.3	9.1	2.4	3.0
Impedance of arm (left)	5.6	26.1	26.8	-5.0	-5.2
Bipolar Disorder (2018)	5.5	8.7	10.1	-3.2	-2.7
Qualifications: College or University degree	5.3	16.6	18.4	-3.8	-4.3
Average weekly spirits intake	5.2	6.5	7.5	2.4	2.7
Vitamin and mineral supplements	5.2	7.1	7.8	-2.8	-2.5
Leg fat-free mass (left)	5.1	27.0	30.1	-5.5	-4.9
Leg predicted mass (left)	5.1	27.0	29.9	-5.5	-4.9
Age at First Birth	5.0	7.3	9.2	-2.3	-3.0
Commuting to job workplace: Cycle	5.0	6.1	7.6	-2.8	-2.1
Medication for pain relief, constipation, heartburn	4.8	8.3	8.7	-3.0	-2.8
Illnesses of father: None of the above (group 1)	4.8	6.0	6.0	2.5	2.4
Pain all over the body in last month	4.7	5.0	5.3	2.3	2.2
Sitting height	4.6	32.8	40.4	-6.4	-5.0
Illnesses of siblings	4.6	6.4	7.5	-2.3	-2.7
Frequency of tiredness / lethargy in last 2 weeks	4.6	7.5	7.7	2.8	2.7
Qualifications: O levels/GCSEs or equivalent	4.6	7.3	10.4	-3.2	-2.0
Forced expiratory volume in 1-second (FEV1), predicted	4.6	9.6	11.1	-3.3	-2.8
Unable to work because of sickness or disability	4.6	6.0	7.9	2.0	2.8
Cholesterol lowering medication	4.6	6.7	6.9	-2.6	-2.6
Medication: Paracetamol	4.4	6.8	7.6	2.5	2.8
Type 2 Diabetes (T2D) (2012)	4.3	4.9	6.2	2.5	1.9
Heel T-Score	4.3	34.2	34.9	5.9	5.8
Birth weight	4.3	9.3	10.5	-3.2	-2.9
Depressed Affect (Nagel 2018)	4.2	8.8	9.2	3.0	2.9
Forced vital capacity (FVC)	4.2	16.3	19.4	-4.4	-3.6
Qualifications: nursing, teaching	4.2	6.5	7.2	-2.4	-2.7
Blood Platelet Count	4.1	47.3	48.0	6.9	6.8
Medication: Ramipril	4.1	5.2	5.3	2.3	2.2
Schizophrenia vs Biploar Disorder	4.0	5.2	5.3	2.3	2.3
Medication: Co-codamol	3.9	4.5	5.7	2.4	1.8
Pulse wave Arterial Stiffness index	3.9	4.6	4.6	2.1	2.1
Pulse wave reflection index	3.9	4.8	5.3	2.3	2.1
Medication: Ibuprofen	3.9	4.6	4.8	2.2	2.1
Ever had stillbirth, spontaneous miscarriage or termination	3.7	3.9	4.7	1.8	2.2
Chronic bronchitis/emphysema (mother)	3.6	4.2	5.1	2.2	1.8
Whole body fat-free mass	3.6	20.5	23.5	-4.8	-4.2
Pain type(s) experienced in last month: Hip pain	3.6	4.5	4.6	2.1	2.1
Neuroticism (Nagel 2018)	3.5	8.3	8.9	2.8	3.0
Breast Cancer	3.5	8.4	11.0	-2.4	-3.3
Fed-up feelings	3.5	6.4	6.9	2.6	2.4
Whole body water mass	3.5	19.8	22.6	-4.8	-4.1
Exposure to tobacco smoke at home	3.4	3.8	4.6	1.8	2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.4	4.0	4.9	1.8	2.2
Handedness (chirality/laterality): Left-handed	3.3	3.9	4.3	-2.1	-1.9
Pain experienced in last month	3.3	5.5	5.9	-2.4	-2.3
Impedance of leg (left)	3.1	15.3	15.8	4.0	3.8
Fluid intelligence score	3.1	6.4	6.6	-2.6	-2.5
Headache pain in last month	3.1	5.3	7.5	2.7	1.8
Average weekly champagne plus white wine intake	3.1	4.2	4.7	-2.2	-1.9
Trunk fat-free mass	3.0	17.2	19.9	-4.5	-3.8
Alcohol intake versus 10 years previously	3.0	4.4	4.7	2.0	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	3.0	9.7	12.0	-3.5	-2.7
Impedance of leg (right)	2.9	14.2	15.9	4.0	3.5
Hayfever, allergic rhinitis or eczema	2.9	6.3	8.1	-2.1	-2.8
Mouth/teeth dental problems	2.9	4.5	5.0	-2.2	-2.0
Trunk predicted mass	2.9	16.6	19.3	-4.4	-3.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.9	3.4	3.8	1.7	1.9
Lung FEV1/FVC ratio	2.8	14.1	15.3	3.6	3.9
Basal metabolic rate	2.8	15.3	17.6	-4.2	-3.6
Supplements: Calcium	2.8	3.0	3.7	1.9	1.6
Schizophrenia (2014)	2.7	5.9	7.6	2.0	2.8
Number of self-reported non-cancer illnesses	2.7	4.6	4.6	2.1	2.1
Mother’s age at death	2.7	3.4	4.9	-1.4	-2.2
Multivitamins +/- minerals	2.5	3.2	3.2	1.8	1.8
Supplements: Glucosamine	2.5	3.3	3.9	-1.7	-2.0
Breastfed as a baby	2.5	3.1	3.2	-1.8	-1.8
Smoking status: Current	2.5	4.0	4.4	2.1	1.9
Schizophrenia (2018)	2.4	4.9	6.4	1.9	2.5
Allergy or Eczema	2.4	6.4	8.6	-2.1	-2.9
Current tobacco smoking	2.4	3.9	4.4	2.1	1.9
Pulse rate	2.4	4.0	4.3	1.9	2.1
Mouth/teeth dental problems: Mouth ulcers	2.4	3.8	4.3	2.1	1.8
Waist Hip Ratio (WHR)	2.3	10.2	11.6	3.4	3.0
Allergy	2.3	5.3	7.7	1.7	2.8
Body mass index (BMI)	2.2	9.4	10.0	3.2	3.0
Lung cancer (father)	2.2	2.5	2.8	1.7	1.5
Wheeze or whistling in the chest in last year	2.2	3.9	4.0	2.0	1.9
Osteoporosis (self-reported)	2.1	2.7	2.7	1.6	1.6
Alcohol drinker status: Previous	2.1	2.4	3.5	1.1	1.9
Hypertension (Self-reported)	2.0	5.6	5.9	2.4	2.3
Intelligence (Savage-Jansen 2018)	1.9	5.9	6.6	-2.3	-2.6
Lupus	1.9	2.9	3.1	-1.7	-1.7
BMI	1.9	10.8	11.4	3.4	3.2
Prospective memory result	1.9	2.4	2.8	1.7	1.4
Leg fat mass (right)	1.9	7.2	7.6	2.8	2.6
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	3.1	1.8	1.2
Irritability	1.9	3.2	3.9	-2.0	-1.6
Ever used hormone-replacement therapy (HRT)	1.8	2.2	2.3	1.5	1.5
Father’s age at death	1.8	2.4	3.0	-1.7	-1.3
Illnesses of mother	1.8	2.2	3.0	-1.7	-1.2
Comparative body size at age 10	1.8	4.9	6.4	-1.9	-2.5
Medication: Allopurinol	1.8	2.4	3.2	1.3	1.8
Heart disease (mother)	1.8	2.2	3.3	-1.0	-1.8
Guilty feelings	1.8	2.6	3.3	1.8	1.4
Leg fat mass (left)	1.8	7.2	7.3	2.7	2.6
Neck or shoulder pain in last month	1.7	2.4	2.9	1.4	1.7
Had major operations	1.7	2.0	2.2	-1.3	-1.5
Long-standing illness, disability or infirmity	1.7	2.7	3.0	1.7	1.5
Blood Red Count	1.6	15.1	19.9	4.5	3.2
Chronotype (morning person)	1.6	3.8	4.6	-1.7	-2.1
Hand grip strength (left)	1.6	4.2	6.0	-2.5	-1.6
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	2.5	-1.6	-1.3
Forced expiratory volume in 1-second (FEV1)	1.6	5.4	7.5	-2.7	-1.8
Happiness	1.6	2.0	2.6	-1.2	-1.6
Depression (self-reported)	1.6	1.9	2.7	1.0	1.7
Osteoarthritis (self-reported)	1.6	2.1	2.6	1.3	1.6
Medication: Blood pressure	1.6	3.1	3.3	1.8	1.7
HbA1C	1.5	1.7	2.3	1.5	1.1
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	2.3	1.5	1.3
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	2.3	1.1	1.5
Eye problems/disorders: None of the above	1.5	1.8	1.9	-1.4	-1.3
Number of full sisters	1.5	1.8	2.8	0.9	1.7
Alzheimer’s Disease (including proxy)	1.4	2.0	2.6	1.6	1.1
Number of incorrect matches in round	1.4	2.3	2.6	1.6	1.4
Had menopause	1.4	1.8	2.2	1.5	1.2
Gout (self-reported)	1.4	1.9	1.9	1.4	1.4
Vascular/heart problems diagnosed by doctor	1.4	3.7	4.1	-1.8	-2.0
Worry too long after embarrassment	1.3	2.2	3.0	1.1	1.7
Chest pain or discomfort	1.3	1.9	2.0	1.4	1.4
Heart disease (siblings)	1.3	1.6	2.4	-1.6	-0.9
Prostate Cancer	1.2	1.7	2.4	1.0	1.5
Body Mass Index (BMI) (2010)	1.2	1.6	1.7	-1.2	-1.3
Neuroticism (2016)	1.2	1.8	1.8	1.3	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	2.1	1.1	1.5
Qualifications: CSEs or equivalent	1.2	1.6	1.6	1.3	1.2
Hair/balding pattern: Pattern 3	1.2	1.8	1.9	-1.4	-1.3
Peak expiratory flow (PEF)	1.2	2.8	3.7	-1.9	-1.4
Financial situation satisfaction	1.2	1.5	1.9	-1.1	-1.4
Alzheimer’s Disease (in father)	1.1	1.2	1.4	1.0	1.2
Major Depression (MDD)	1.1	1.3	1.6	-1.3	-1.0
Crohns Disease (2012)	1.1	1.8	2.2	1.5	1.2
Medication for hormone replacement therapy	1.1	1.2	1.4	1.2	1.0
High blood pressure	1.1	2.9	3.0	1.7	1.7
Asthma	1.1	2.2	2.7	-1.3	-1.6
Shortness of breath walking on level ground	1.1	1.4	1.6	1.3	1.1
Emphysema/chronic bronchitis	1.1	1.2	1.9	1.4	0.7
Bipolar Disorder (2011)	1.0	0.9	1.0	-0.9	-1.0
Blood Eosinophil Count	1.0	7.7	8.2	2.7	2.9
Severe depression (siblings)	1.0	1.2	1.3	1.1	1.0
Pack years adult smoking proportion	1.0	1.5	2.1	1.4	0.9
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	1.2	1.0	1.1
Body fat percentage	1.0	4.0	4.7	2.2	1.8
Health satisfaction	1.0	1.3	2.2	1.5	0.6
Family relationship satisfaction	1.0	1.3	2.1	1.5	0.7
Average weekly beer plus cider intake	1.0	1.4	1.5	1.2	1.2
Smoking Status	0.9	2.1	2.6	1.6	1.2
Average weekly fortified wine intake	0.9	1.0	1.5	1.2	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	2.6	1.2	1.6
Falls in the last year	0.9	1.2	1.3	1.1	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	1.7	1.3	0.7
Medication: Blood pressure	0.9	1.5	1.7	1.2	1.3
Age started oral contraceptive pill	0.9	1.2	1.4	-1.2	-1.0
Depression (Nagel 2018)	0.8	1.2	1.6	0.9	1.3
Ulcerative Colitis	0.8	1.1	1.6	0.8	1.3
Diabetes (father)	0.8	1.0	1.2	1.1	0.9
Waist circumference	0.8	3.0	3.8	1.9	1.5
Time employed in main current job	0.8	1.0	1.0	0.9	1.0
Worrier / anxious feelings	0.8	1.6	1.8	1.2	1.3
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	1.8	1.3	1.0
Ever had bowel cancer screening	0.8	0.9	1.0	1.0	1.0
Medication for cholesterol	0.8	1.2	1.2	-1.1	-1.1
Alcohol drinker status: Never	0.8	1.0	1.7	-1.3	-0.5
Crohns Disease (2017)	0.7	1.4	1.9	1.4	1.0
Hand grip strength (right)	0.7	1.8	2.7	-1.6	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	1.4	-1.2	-0.8
Financial difficulties in last 2 years	0.7	0.9	1.4	1.2	0.7
Ever highly irritable/argumentative for 2 days	0.7	0.8	0.9	0.9	0.9
Number of children fathered	0.7	0.8	1.5	1.2	0.4
Knee pain experienced in last month	0.7	1.0	1.6	1.2	0.7
Asthma (self-reported)	0.7	1.5	2.0	-1.0	-1.4
Commuting to job workplace: Public transport	0.7	0.8	0.8	-0.9	-0.9
Eye problems/disorders: Glaucoma	0.7	0.9	1.3	-0.6	-1.2
Ever smoked	0.7	1.2	1.8	-0.7	-1.3
Neuroticism	0.6	1.5	1.8	1.1	1.3
Relative age of first facial hair	0.6	1.3	1.5	1.2	1.0
Weight	0.6	2.8	3.2	-1.8	-1.6
Noisy workplace	0.6	0.8	0.8	-0.9	-0.9
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	1.9	0.7	1.4
Arm fat-free mass (right)	0.6	2.9	4.2	-2.0	-1.3
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.0	1.0	0.6
Tinnitus: Yes, now most or all of the time	0.6	0.7	0.8	0.9	0.8
Medication: Bendroflumethiazide	0.6	0.9	1.1	0.9	1.0
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.3	1.1	0.2
Verbal and Numeric Reasoning (VNR)	0.5	1.2	1.6	-0.9	-1.3
Mean Putamen Volume	0.5	0.5	0.9	-0.9	-0.5
Blood White Count	0.5	3.8	5.0	2.2	1.6
Relative age voice broke	0.5	0.7	0.9	-1.0	-0.8
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	0.9	-0.9	-0.6
Medication: Levothyroxine sodium	0.5	0.9	1.3	0.7	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	1.7	0.7	1.3
Mouth/teeth dental problems: Dentures	0.5	0.8	1.0	0.9	1.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.3	1.1	0.4
Mouth/teeth dental problems: Loose teeth	0.5	0.6	0.7	0.7	0.9
Migraine (self-reported)	0.5	0.6	0.8	0.9	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.7	0.9	-0.6	-1.0
Arm predicted mass (right)	0.5	2.5	3.6	-1.9	-1.1
Supplements: Vitamin C	0.5	0.6	0.7	0.8	0.8
Ever taken oral contraceptive pill	0.5	0.5	1.0	1.0	0.4
Arm fat-free mass (left)	0.5	2.6	3.4	-1.8	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	0.6	0.7	0.8
Arm predicted mass (left)	0.5	2.4	3.3	-1.8	-1.2
Irritable Bowel Disease (IBD)	0.4	0.9	1.1	0.9	1.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.6	-0.8	-0.6
Supplements: Zinc	0.4	0.5	0.7	-0.5	-0.8
Hearing difficulty/problems with background noise	0.4	0.6	1.1	1.1	0.1
Medication: Amlodipine	0.4	0.5	0.6	-0.8	-0.6
Medication: Omeprazole	0.4	0.5	0.7	0.8	0.5
Alcohol intake frequency.	0.4	1.0	1.0	1.0	1.0
Commuting to job workplace: Walk	0.4	0.4	0.8	-0.9	-0.1
Risk taking	0.4	0.6	0.9	0.9	0.6
Heart attack/myocardial infarction (self-reported)	0.4	0.6	0.7	-0.8	-0.7
Pack years of smoking	0.4	0.7	1.1	1.0	0.5
Ovarian Cancer	0.3	0.4	0.6	-0.8	-0.4
Primary Biliary Cirrhosis	0.3	0.4	0.6	0.4	0.8
Rheumatoid Arthritis	0.3	0.4	0.6	0.4	0.8
Chronic bronchitis/emphysema (father)	0.3	0.3	0.6	-0.8	-0.2
Blood clot in the leg (DVT)	0.3	0.4	0.7	0.9	-0.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.4	0.7	0.6
High blood pressure (siblings)	0.3	0.4	0.6	0.4	0.8
Exposure to tobacco smoke outside home	0.3	0.4	0.5	-0.7	-0.5
Leg pain on walking	0.3	0.4	0.6	0.4	0.8
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.7	0.8	0.3
Mineral and other dietary supplements	0.3	0.4	0.6	0.4	0.8
Medication: Aspirin	0.3	0.3	0.4	0.6	0.5
Ever depressed for a whole week	0.3	0.3	0.6	0.2	-0.8
Alzheimer’s Disease (in mother)	0.2	0.3	0.6	0.7	0.1
Hypothyroidism (self reported)	0.2	0.5	0.9	0.1	1.0
Hearing difficulty/problems: Yes	0.2	0.2	0.4	0.3	-0.6
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	0.6	-0.3
Trunk fat mass	0.2	0.7	0.8	-0.8	-0.9
Had other major operations	0.2	0.2	0.3	0.5	-0.5
Heart attack	0.2	0.3	0.4	-0.6	-0.5
Arm fat percentage (right)	0.2	0.6	0.8	0.9	0.6
Hip circumference	0.2	0.7	0.9	-0.9	-0.7
Loud music exposure frequency	0.2	0.2	0.2	-0.5	-0.5
Pulse rate, automated reading	0.2	0.5	0.8	0.9	0.5
Arm fat percentage (left)	0.2	0.6	0.8	0.9	0.7
Average weekly red wine intake	0.2	0.3	0.4	-0.6	-0.5
Eye problems/disorders: Cataract	0.2	0.2	0.2	0.5	0.5
Miserableness	0.2	0.4	0.8	0.9	0.1
Illnesses of father: High blood pressure	0.2	0.3	0.5	0.7	0.3
Number of operations (self-reported)	0.2	0.2	0.3	-0.4	-0.6
Fractured/broken bones in last 5 years	0.2	0.2	0.4	-0.1	0.7
Myopia	0.2	0.2	0.3	0.6	0.4
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	0.0	0.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.3	0.5	-0.4
Impedance of whole body	0.2	0.8	0.8	-0.9	-0.9
Bipolar Disorder or Schizophrenia	0.1	0.2	0.3	-0.5	0.3
Ulcerative Colitis (UC)	0.1	0.1	0.2	-0.4	0.3
Reaction Time	0.1	0.1	0.2	-0.4	-0.3
HDL Cholesterol	0.1	0.2	0.3	-0.5	-0.2
Hair Pigment	0.1	2.3	2.7	1.6	1.4
Tanning	0.1	0.7	0.7	0.8	0.8
Systolic blood pressure, automated reading	0.1	0.3	0.4	0.6	0.5
Townsend deprivation index at recruitment	0.1	0.2	0.3	0.3	-0.6
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.3	-0.2	-0.5
Alcohol usually taken with meals	0.1	0.1	0.2	-0.3	-0.4
Nervous feelings	0.1	0.2	0.4	-0.6	-0.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.2	0.5	-0.4
Neuroticism score	0.1	0.2	0.3	0.5	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.5	0.2
Hair/balding pattern: Pattern 4	0.1	0.2	0.3	0.6	0.2
Glaucoma (self-reported)	0.1	0.1	0.1	0.1	-0.3
Number of full brothers	0.1	0.1	0.2	0.5	0.1
Suffer from ‘nerves’	0.1	0.2	0.4	-0.1	-0.6
Medication: Aspirin	0.1	0.1	0.2	0.4	0.2
Back pain experienced in last month	0.1	0.1	0.2	-0.2	0.5
Breast cancer (self-reported)	0.1	0.1	0.1	-0.2	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	0.1	0.5
Hearing aid user	0.1	0.1	0.1	0.3	0.3
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	-0.3	-0.4
Medication: Lisinopril	0.1	0.1	0.1	-0.4	-0.2
Worry (Nagel 2018)	0.0	0.1	0.2	0.0	0.4
Systolic Blood Pressure	0.0	0.2	0.2	0.4	0.4
Cardiovascular Disease	0.0	0.1	0.1	-0.2	0.3
Respiratory disease	0.0	0.1	0.2	-0.0	-0.4
Lung FVC	0.0	0.0	0.0	0.0	0.0
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.0	-0.1	0.1
Angina	0.0	0.0	0.0	0.0	0.0
Trunk fat percentage	0.0	0.0	0.1	0.2	0.0
Age when periods started (menarche)	0.0	0.1	0.2	0.2	0.4
Serious illness, injury or assault to yourself	0.0	0.0	0.0	0.1	-0.1
Medication: Atenolol	0.0	0.0	0.1	0.3	0.0
High blood pressure (mother)	0.0	0.0	0.1	0.2	0.2
Past tobacco smoking	0.0	0.0	0.0	-0.1	0.2
Arm fat mass (right)	0.0	0.1	0.1	0.3	0.2
Length of working week for main job	0.0	0.0	0.1	-0.2	-0.0
Tense / ‘highly strung’	0.0	0.0	0.0	-0.2	-0.1
Angina (self-reported)	0.0	0.0	0.0	-0.1	-0.0
Medication: Seretide 50 evohaler	0.0	0.0	0.0	-0.1	-0.0
Mean time to correctly identify matches	0.0	0.1	0.1	0.3	0.2
Whole body fat mass	0.0	0.0	0.1	0.3	0.1
Smoking status: Previous	0.0	0.1	0.1	0.3	-0.1
Mood swings	0.0	0.0	0.0	-0.0	0.2
Friendships satisfaction	0.0	0.0	0.0	0.2	-0.0
Arm fat mass (left)	0.0	0.0	0.0	0.2	0.1
Wears glasses or contact lenses	0.0	0.0	0.0	0.0	0.1

Hub : Genes

TM6SF2

Models

Trait associations