Hub : Genes

ATP13A1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellar Hemisphere 0.1890 0.0940 9.5e-03 0.150 NA 0.039 NA 0.070 1.1e-04 NA 3.6e-02 NA 7.3e-03
2 GTEx Brain Cerebellum 0.1680 0.0860 7.0e-03 0.030 NA 0.028 NA 0.017 4.6e-02 NA 5.2e-02 NA 1.0e-01
3 GTEx Cells Transformed fibroblasts 0.1390 0.0630 4.0e-03 0.064 NA 0.028 NA 0.046 1.5e-05 NA 3.4e-03 NA 2.2e-04
4 GTEx Spleen 0.1590 0.0810 8.9e-03 0.007 NA 0.008 NA 0.021 2.0e-01 NA 1.9e-01 NA 9.7e-02
5 NTR Blood 0.0129 0.0065 4.4e-03 0.005 0.010 0.007 0.010 0.002 5.8e-03 1.9e-04 2.5e-03 2.8e-04 4.7e-02
6 ROSMAP Brain Pre-frontal Cortex 0.1014 0.0317 1.2e-06 0.067 0.048 0.042 0.055 0.064 5.4e-09 7.7e-07 4.0e-06 1.3e-07 1.3e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 5.5 8.6 19.4 4.4 4.0 -2.1 2.5 -0.2 2.4
Bipolar Disorder or Schizophrenia 5.6 13.6 26.9 5.2 5.0 0.1 5.1 1.9 0.6
Depressed Affect (Nagel 2018) 0.4 0.8 2.1 -0.1 0.9 0.8 1.1 1.4 -0.3
Depression (Nagel 2018) 0.2 0.3 1.0 -1.0 -0.1 0.5 -0.6 -0.6 -0.3
Intelligence (Savage-Jansen 2018) 2.6 7.9 20.2 1.7 1.5 -3.2 -1.3 -3.2 4.5
Neuroticism (Nagel 2018) 1.8 4.3 10.2 1.4 3.2 1.2 2.3 2.5 -0.5
Schizophrenia (2018) 4.2 8.7 20.3 3.1 3.2 1.8 4.5 2.7 -1.2
Schizophrenia vs Biploar Disorder 1.3 1.8 5.5 -0.3 0.1 1.4 1.4 2.4 -1.1
Worry (Nagel 2018) 1.8 3.8 11.9 1.5 3.5 0.5 2.0 1.9 0.7
Alzheimer’s Disease (in mother) 0.6 0.6 2.6 0.7 0.2 0.4 1.6 0.4 -0.6
Alzheimer’s Disease (in father) 0.4 0.4 0.9 -0.7 -0.0 -1.0 -0.8 0.6 0.3
Alzheimer’s Disease (including proxy) 0.3 0.4 1.1 0.2 0.5 -0.1 1.0 0.9 -0.4
Crohns Disease (2017) 2.0 4.4 6.5 2.6 1.3 1.7 2.4 2.4 -2.0
Irritable Bowel Disease (IBD) 1.8 4.2 9.7 2.3 1.4 1.1 2.2 3.1 -1.5
Ulcerative Colitis (UC) 0.9 1.7 4.8 1.5 1.4 -0.2 1.1 2.2 -0.1
Major Depression (MDD) 1.2 1.5 4.1 0.6 0.7 -1.2 -1.1 -1.1 2.0
Reaction Time 0.6 1.2 3.1 -1.3 -0.6 -1.1 -0.1 -0.8 1.8
Verbal and Numeric Reasoning (VNR) 1.3 3.2 8.8 0.8 0.3 -1.9 -1.5 -2.0 3.0
Breast Cancer 6.0 14.3 43.7 -3.7 -1.7 -1.9 -6.6 -4.6 0.9
Ovarian Cancer 2.5 3.2 6.7 -1.8 -0.8 -2.5 -2.6 -1.6 0.4
Prostate Cancer 4.2 5.9 10.5 3.2 3.1 1.1 3.1 2.1 -0.6
Age at First Birth 0.7 1.0 1.8 0.9 1.1 -0.9 -0.5 -1.0 1.3
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 2.3 3.2 5.5 -1.7 -1.0 -0.8 -2.3 -2.3 1.9
Coronary Artery Disease (CAD) 2.8 3.4 7.7 -0.7 0.4 -2.5 -2.0 -1.3 2.8
Crohns Disease (2012) 0.8 1.2 3.0 1.1 1.1 -0.2 1.1 1.7 -0.8
Mean Putamen Volume 0.9 1.0 2.3 1.5 0.9 0.8 0.9 0.3 -1.3
Fasting Glucose 2.2 2.7 6.5 -0.4 -0.8 0.6 2.1 1.9 -2.5
HbA1C 1.5 1.6 5.2 -1.4 -1.1 0.6 -0.1 2.3 -1.0
HDL Cholesterol 0.1 0.2 0.6 0.8 -0.2 0.4 0.0 -0.6 0.5
LDL Cholesterol 19.0 30.0 83.9 0.6 2.1 -9.2 -3.3 -4.3 7.9
Lupus 0.3 0.5 1.8 1.3 0.4 -0.9 0.2 -0.4 -0.1
Neuroticism (2016) 0.8 1.2 2.3 -1.4 -0.3 0.9 1.3 1.5 -0.5
Primary Biliary Cirrhosis 0.3 0.4 1.2 -0.3 0.4 1.0 -1.1 0.1 -0.4
Rheumatoid Arthritis 3.1 4.3 11.3 2.4 1.5 0.6 3.4 2.4 -0.6
Schizophrenia (2014) 5.5 12.2 24.5 3.8 4.3 2.0 5.0 3.3 -0.9
Triglycerides 25.4 41.7 112.4 0.5 2.5 -10.6 -4.5 -6.2 8.5
Type 2 Diabetes (T2D) (2012) 3.2 3.7 10.6 0.0 0.2 3.3 1.7 2.1 -2.0
Ulcerative Colitis 0.6 0.8 3.8 -0.0 0.8 0.3 -0.2 1.9 -0.4
Blood Eosinophil Count 2.7 20.7 38.7 4.7 4.0 3.2 6.2 5.2 -3.2
Blood Platelet Count 7.3 85.2 166.4 4.9 3.7 9.5 11.6 9.1 -12.9
Blood Red Count 2.5 24.0 51.0 -5.0 -5.2 6.0 -1.7 1.3 -7.1
Blood White Count 1.4 10.3 27.2 1.3 -0.2 3.9 3.4 2.5 -5.2
Heel T-Score 1.4 10.8 18.7 -1.0 -0.5 4.3 3.5 3.8 -4.3
BMI 1.0 5.8 13.7 -3.7 -1.5 -1.9 -2.6 0.2 3.0
Height 3.0 58.3 110.2 10.5 9.7 -8.3 1.8 -5.5 6.6
Waist Hip Ratio (WHR) 2.1 9.4 19.8 -2.0 -3.8 4.0 -1.1 -0.3 -4.5
Systolic Blood Pressure 1.4 6.9 22.2 2.3 1.0 2.9 1.8 1.1 -4.7
Smoking Status 0.4 0.9 2.5 0.3 -0.2 1.6 1.4 0.6 -0.6
Allergy or Eczema 0.5 1.3 3.4 0.7 0.6 -1.8 0.9 0.7 1.6
Cardiovascular Disease 0.6 2.0 7.1 -1.4 -1.6 -0.0 -2.7 -0.2 -0.7
Hypothyroidism (self reported) 1.4 3.1 6.6 2.2 2.6 -0.3 2.3 -1.4 0.4
Respiratory disease 0.4 0.9 1.1 -1.0 0.8 -1.0 -0.9 -0.9 1.1
Type 2 Diabetes (T2D) (2018) 4.3 8.0 20.3 -1.4 -0.7 4.2 1.2 2.5 -4.5
Lung FEV1/FVC ratio 0.6 3.1 6.1 -1.2 -1.8 2.5 0.3 2.4 -1.5
Lung FVC 0.1 0.3 1.0 -0.4 -0.5 0.2 0.0 0.6 1.0
Neuroticism 0.9 2.2 7.7 1.0 2.8 0.1 1.6 1.2 0.5
Chronotype (morning person) 0.3 0.7 2.0 0.1 -1.4 0.5 -1.2 -0.6 -0.4
Hair Pigment 0.1 2.4 6.2 -0.5 -1.3 2.5 -0.2 1.4 -2.0
Tanning 0.0 0.3 1.3 -0.4 -0.0 -0.1 -0.3 0.2 1.1
Hand grip strength (left) 0.4 1.0 3.8 0.9 0.9 -0.3 -0.2 -2.0 0.6
Number of treatments/medications taken 1.5 2.7 9.6 -3.1 -1.7 0.4 -0.2 1.3 -1.4
Average weekly spirits intake 0.5 0.6 2.6 -1.6 0.5 -0.1 0.5 0.6 0.4
Sensitivity / hurt feelings 5.0 8.5 17.1 0.9 2.1 2.5 4.1 3.6 -3.1
Frequency of depressed mood in last 2 weeks 0.9 1.2 2.2 -0.7 -0.5 -1.1 -1.5 -1.4 1.1
Hearing difficulty/problems: Yes 3.1 4.8 12.5 -2.7 -2.5 -0.9 -3.5 -1.0 0.5
Relative age of first facial hair 0.3 0.6 2.5 -0.3 0.3 1.6 0.0 0.5 -0.7
Other serious medical condition/disability diagnosed by doctor 1.1 1.4 4.4 -0.9 -2.1 -1.5 -0.7 -0.2 0.7
Ever used hormone-replacement therapy (HRT) 1.8 2.2 6.5 -0.8 -0.2 2.5 -0.3 -0.2 -2.6
Ever had hysterectomy (womb removed) 1.2 1.4 3.1 1.1 0.2 -1.8 0.8 -0.3 1.8
Systolic blood pressure, automated reading 0.6 1.9 6.3 1.6 1.1 0.9 0.5 0.1 -2.5
Eye problems/disorders: Diabetes related eye disease 1.9 2.0 4.6 -0.9 -1.3 1.9 0.5 1.2 -2.1
Angina 2.8 3.7 6.0 -1.8 -1.4 -2.3 -2.2 -2.5 1.0
Medication for hormone replacement therapy 0.7 0.8 2.1 0.2 -0.6 1.5 0.5 -1.0 -0.8
Vitamin and mineral supplements 2.1 2.8 5.9 -0.4 -0.9 -1.7 -2.1 -1.7 2.4
Supplements: Zinc 0.7 0.8 1.6 0.7 1.3 -0.8 0.4 0.3 1.3
Medication: Co-codamol 0.7 0.8 3.9 0.0 0.4 0.6 2.0 -0.0 -0.6
Medication: Metformin 2.0 2.8 9.4 -0.6 0.1 2.0 0.8 1.6 -3.1
Diabetes (father) 0.9 1.1 2.6 -0.1 -0.7 1.6 1.2 0.9 -1.2
Diabetes (mother) 6.2 7.9 17.0 0.6 0.1 4.1 2.7 3.0 -3.7
Severe depression (siblings) 1.1 1.2 3.8 0.7 1.0 -0.8 2.0 0.9 0.4
Pack years adult smoking proportion 1.2 1.8 3.0 1.1 -0.3 1.6 1.7 1.6 -1.2
Impedance of leg (right) 3.5 16.9 38.5 2.6 2.1 4.2 6.2 3.9 -4.4
Leg fat-free mass (left) 3.1 16.4 32.2 1.2 2.0 -5.5 -3.6 -4.1 5.7
Trunk fat percentage 1.6 6.2 19.9 1.5 2.8 -2.7 0.6 0.6 4.5
Hand grip strength (right) 0.3 0.8 4.2 0.1 0.2 0.1 -0.5 -2.0 -0.5
Townsend deprivation index at recruitment 4.1 5.7 16.2 -3.2 -4.0 -0.5 -2.2 -0.6 1.4
Current tobacco smoking 0.8 1.3 3.5 0.6 -0.6 0.9 1.6 1.9 -0.4
Average weekly fortified wine intake 1.0 1.2 3.2 -1.2 -1.2 1.8 -0.3 0.3 -1.0
Maternal smoking around birth 2.7 4.0 8.1 1.1 1.2 2.8 2.5 1.5 -2.1
Fed-up feelings 0.5 0.9 2.7 -0.2 0.2 0.4 1.6 1.6 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 3.8 -0.2 -0.1 1.6 0.2 0.3 -2.0
Relative age voice broke 1.0 1.5 6.6 1.0 2.6 0.6 0.1 -1.0 0.0
Taking other prescription medications 1.7 2.7 7.4 -0.6 0.4 0.7 2.7 2.7 -0.5
Age when periods started (menarche) 0.5 1.3 2.4 1.0 1.3 0.4 1.6 1.3 -0.7
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.3 1.0 1.5 -0.0 0.4 -0.6 1.0
Heel bone mineral density (BMD) T-score, automated (left) 1.3 3.1 6.7 -0.4 0.1 2.6 1.6 2.5 -1.6
Tinnitus: Yes, but not now, but have in the past 1.0 1.0 4.5 0.7 2.1 0.4 0.4 -0.9 0.1
Qualifications: CSEs or equivalent 0.2 0.3 0.7 -0.2 0.7 0.4 -0.3 0.8 -0.3
Serious illness, injury or assault to yourself 0.8 0.9 3.3 -0.5 0.3 -1.0 -0.7 -0.6 1.8
High blood pressure 0.9 2.6 7.9 -0.3 -1.4 2.0 -0.9 0.9 -2.8
Hayfever, allergic rhinitis or eczema 0.4 0.8 3.8 0.2 0.5 -1.9 0.2 -0.3 0.9
Multivitamins +/- minerals 1.0 1.3 3.4 0.2 -0.3 1.0 1.0 1.5 -1.9
Stomach or abdominal pain in last month 1.7 2.1 4.0 -1.7 0.2 0.9 2.0 1.6 -1.6
Supplements: Glucosamine 0.8 1.0 2.4 0.4 1.5 -1.2 -0.7 -0.9 1.0
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 2.7 -1.6 -0.4 -1.4 -1.0 -0.3 1.3
Medication: Atenolol 1.1 1.4 3.6 0.1 -1.1 1.5 -0.4 -1.1 -1.9
Medication: Levothyroxine sodium 1.6 2.7 7.6 2.3 1.1 1.0 2.8 0.4 -0.9
Sitting height 2.6 18.6 39.3 5.7 6.3 -4.5 1.7 -2.2 3.4
Chronic bronchitis/emphysema (father) 0.3 0.4 1.0 0.5 0.4 -0.0 -0.5 -1.0 0.7
High blood pressure (mother) 1.8 2.5 8.4 2.1 2.9 0.3 1.1 0.9 -0.5
Body mass index (BMI) 0.5 2.1 4.8 -2.2 -1.1 -0.6 -1.7 0.7 1.8
Impedance of leg (left) 3.5 17.2 37.1 2.3 1.9 4.4 6.1 4.1 -4.6
Leg predicted mass (left) 3.1 16.4 32.5 1.2 1.9 -5.5 -3.6 -4.1 5.7
Trunk fat mass 1.8 7.6 23.5 1.5 2.8 -3.4 -0.3 -0.3 4.8
Waist circumference 0.5 1.7 4.2 -1.3 -0.9 -0.8 -2.0 -0.0 1.7
Number of incorrect matches in round 0.6 1.0 3.6 -1.9 -0.2 0.8 0.2 1.1 -0.9
Past tobacco smoking 0.2 0.4 1.1 -0.7 -0.6 -1.1 -0.2 0.7 0.1
Alcohol usually taken with meals 1.0 1.7 4.0 1.3 0.9 2.0 0.8 0.3 -1.7
Nervous feelings 1.1 2.0 5.7 1.0 2.4 -1.1 0.8 1.4 1.3
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.3 2.4 -1.5 -1.1 -0.3 -1.5 -1.3 0.7
Hearing difficulty/problems with background noise 0.8 1.3 3.3 -0.7 -1.8 0.5 -0.8 1.3 -1.2
Hair/balding pattern: Pattern 2 1.7 2.2 7.2 -0.1 0.1 1.5 1.8 2.7 -0.5
Had menopause 1.0 1.3 3.7 -1.0 -1.1 1.9 -0.6 0.2 -1.2
Had other major operations 0.0 0.1 0.1 0.3 0.0 -0.4 -0.2 0.1 0.1
Forced vital capacity (FVC) 1.3 4.8 10.3 1.2 1.4 -3.2 -1.0 -2.4 3.0
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 5.3 -0.7 0.4 2.3 1.1 1.5 -1.3
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 1.4 -1.1 -0.7 -0.6 -1.0 0.8 1.2
Qualifications: None of the above 2.9 6.1 13.3 -0.7 -0.2 2.9 2.3 3.0 -3.6
Financial difficulties in last 2 years 0.8 1.1 2.5 -1.6 -1.1 -0.8 -1.3 0.8 0.2
Mouth/teeth dental problems 1.3 2.0 6.9 2.6 1.5 -0.7 0.3 -1.1 1.1
Heart attack 1.1 1.4 3.6 1.9 0.9 -1.5 1.0 -0.1 0.8
Allergy 1.0 2.3 9.0 -0.2 -0.7 3.0 0.1 0.3 -2.1
Pain all over the body in last month 0.9 1.0 3.3 -0.8 -0.1 0.8 -0.0 1.8 -1.1
Diabetes (self-reported) 4.0 6.2 20.4 -0.4 -1.0 3.8 1.0 0.6 -4.5
Hayfever/allergic rhinitis (self-reported) 2.4 3.2 8.3 -0.6 0.8 -2.9 -0.8 -1.8 2.5
Medication: Ramipril 3.0 3.8 7.7 2.5 -0.3 2.3 1.2 1.5 -2.8
Medication: Simvastatin 7.1 10.5 23.1 0.1 -1.2 -4.8 -4.5 -2.3 3.6
Fluid intelligence score 2.9 6.0 17.0 0.6 -0.4 -2.2 -2.4 -2.8 4.1
Illnesses of siblings 1.0 1.4 3.6 1.5 -0.5 -1.9 0.2 -0.3 1.6
Neuroticism score 0.6 1.2 2.9 0.7 1.2 -1.2 0.9 0.5 1.7
Weight 1.5 7.2 18.2 1.0 1.8 -3.8 -1.9 -1.6 4.3
Impedance of arm (right) 3.3 15.2 32.9 5.7 5.0 -3.5 3.0 -1.3 3.2
Arm fat percentage (right) 0.8 3.3 12.2 0.1 1.1 -2.4 -0.7 0.4 3.5
Trunk fat-free mass 1.4 7.9 12.6 0.6 1.0 -3.5 -3.5 -3.5 3.0
Hip circumference 1.6 6.8 22.7 0.8 2.3 -3.4 -1.1 -0.3 4.8
Time employed in main current job 2.3 2.6 3.8 2.0 -0.2 1.7 1.9 1.9 -1.3
Alcohol intake versus 10 years previously 1.3 2.0 3.8 1.0 0.6 1.3 1.9 1.3 -1.9
Father’s age at death 0.7 1.0 3.0 1.7 1.5 0.1 0.2 -0.2 0.8
Worrier / anxious feelings 0.5 1.0 3.6 -0.4 0.2 0.2 1.9 1.5 0.1
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 2.1 -1.0 -0.6 1.4 1.1 1.1 -0.9
Falls in the last year 1.4 1.9 6.5 1.3 0.4 -0.3 1.7 2.5 0.3
Hair/balding pattern: Pattern 3 1.1 1.6 4.0 -0.7 -0.3 -2.0 -1.4 -1.1 1.3
Number of live births 1.9 2.7 6.8 -0.6 -0.4 2.6 1.2 1.0 -2.6
Forced expiratory volume in 1-second (FEV1) 0.6 2.1 4.5 0.9 1.0 -1.6 -0.6 -1.7 2.1
Pulse rate 2.0 3.4 6.8 1.2 0.0 1.3 2.6 2.6 -1.9
Happiness 2.5 3.1 11.4 0.6 -0.2 -2.3 -0.9 -0.5 3.4
Noisy workplace 0.8 0.9 2.0 1.0 0.9 -1.4 0.1 -0.0 1.3
Qualifications: A levels/AS levels or equivalent 3.0 6.5 13.2 1.1 0.9 -3.6 -1.2 -3.1 3.6
Serious illness, injury or assault of a close relative in last 2 years 3.9 4.4 9.7 0.3 1.3 -3.1 -1.3 -2.1 3.0
Mouth/teeth dental problems: Dentures 1.0 1.7 4.5 -1.4 -1.3 1.4 0.3 0.5 -2.1
Asthma 1.5 2.9 5.9 -0.8 1.1 -2.4 -1.1 -1.7 2.3
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 2.2 -0.0 0.1 -0.5 1.3 1.5 0.6
Medication: Cholesterol lowering 14.1 22.0 55.7 -1.2 -1.0 -7.5 -5.2 -3.1 6.1
Depression (self-reported) 1.2 1.4 3.1 -1.8 0.2 -1.5 -1.4 -0.3 1.1
Medication: Lansoprazole 1.5 1.7 3.6 -1.0 -1.4 1.9 0.8 1.3 -1.2
Prospective memory result 2.9 3.5 7.7 -1.6 -0.1 1.7 1.2 2.5 -2.8
Lung cancer (father) 1.0 1.2 4.2 -0.4 0.1 0.3 0.7 1.4 -2.1
Illnesses of mother 1.5 1.8 5.3 -0.5 -0.3 -1.3 -1.3 -2.3 1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.8 7.4 0.9 0.9 -2.0 -1.2 -1.6 2.7
Pulse wave Arterial Stiffness index 1.7 2.0 3.0 -0.9 -1.7 1.6 0.9 1.4 -1.7
Impedance of arm (left) 2.8 13.1 28.2 5.3 4.7 -2.9 2.8 -1.1 3.2
Arm fat mass (right) 0.9 3.5 11.5 -0.2 1.1 -2.5 -1.4 -0.3 3.4
Trunk predicted mass 1.3 7.7 12.5 0.6 0.9 -3.5 -3.4 -3.5 2.9
Standing height 2.9 29.2 43.3 6.6 6.3 -6.5 -0.6 -5.0 5.0
Length of working week for main job 0.7 0.8 1.5 0.2 0.9 -1.1 1.0 0.5 1.2
Exposure to tobacco smoke at home 1.9 2.1 4.4 0.2 0.7 2.1 1.3 2.1 -1.4
Breastfed as a baby 0.9 1.1 4.6 2.1 -0.1 0.6 0.8 -1.1 -0.0
Tense / ‘highly strung’ 0.2 0.4 0.8 0.1 0.9 -0.4 0.5 0.7 0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 1.9 4.9 -0.3 0.6 -2.1 -1.2 -0.5 2.2
Hair/balding pattern: Pattern 4 0.1 0.3 0.5 -0.3 -0.7 -0.4 -0.7 -0.4 -0.4
Birth weight of first child 4.5 8.1 21.4 2.4 1.6 -4.6 -1.1 -1.9 3.8
Peak expiratory flow (PEF) 2.0 4.6 14.3 0.2 1.6 -2.3 -1.6 -1.7 3.8
Pulse wave reflection index 3.2 4.0 10.7 -3.3 -2.8 1.7 -1.4 0.4 -0.6
Ever highly irritable/argumentative for 2 days 0.7 0.8 3.2 -0.5 0.4 0.0 0.8 1.8 -0.8
Loud music exposure frequency 0.8 0.9 2.2 -0.3 1.5 -1.3 -0.1 -0.3 1.2
Qualifications: O levels/GCSEs or equivalent 1.8 2.8 5.9 2.4 2.3 -1.2 1.0 0.1 1.8
Mouth/teeth dental problems: Bleeding gums 4.1 5.3 19.3 -4.4 -2.6 -0.4 -2.2 -0.5 -0.6
Blood clot in the leg (DVT) 0.2 0.3 1.4 -0.4 -0.2 0.5 0.0 -0.1 -1.2
Medication: Paracetamol 2.9 4.9 9.8 -2.4 -1.0 2.3 1.4 3.1 -2.3
Headache pain in last month 0.9 1.6 8.0 -0.6 0.2 -0.1 2.8 1.1 -0.0
Medication for cholesterol, blood pressure or diabetes 2.3 3.9 7.4 0.6 1.8 2.7 2.7 1.0 -2.0
Glaucoma (self-reported) 0.2 0.2 0.6 -0.3 -0.4 0.2 -0.8 -0.8 -0.0
Gout (self-reported) 2.0 2.8 9.2 -0.6 -0.6 3.0 0.8 0.6 -2.4
Hypothyroidism/myxoedema (self-reported) 1.5 2.9 9.2 1.9 1.9 1.0 3.0 -0.1 -0.1
Medication: Amlodipine 0.8 1.1 3.9 -0.1 -0.7 0.5 -2.0 -1.2 -0.6
Medication: Ventolin 100micrograms inhaler 0.6 0.7 1.4 -1.2 0.4 -0.9 0.6 -0.9 1.0
Birth weight 1.3 2.7 6.0 0.2 1.1 -2.5 -0.9 -2.0 2.0
Chronic bronchitis/emphysema (mother) 0.8 0.9 2.7 -0.7 -1.4 0.4 -0.4 1.6 -0.5
High blood pressure (siblings) 0.4 0.6 1.9 -0.5 0.4 1.1 -0.4 -0.3 -1.4
Forced vital capacity (FVC), Best measure 1.5 5.6 11.2 1.6 1.4 -3.3 -1.3 -2.3 3.3
Body fat percentage 0.7 2.7 9.1 0.3 1.6 -1.4 0.5 1.3 3.0
Leg fat percentage (right) 0.6 2.1 7.9 -1.4 -0.0 1.1 1.2 2.8 0.1
Arm fat-free mass (right) 0.7 3.4 7.8 -0.3 0.6 -2.1 -2.8 -1.8 2.1
Exposure to tobacco smoke outside home 0.1 0.1 0.4 -0.6 0.5 0.1 -0.4 -0.0 0.2
Comparative body size at age 10 3.5 9.6 23.7 -2.5 -2.4 -1.1 -4.3 -4.9 1.5
Number of full brothers 0.4 0.5 1.6 1.3 -0.2 0.3 0.7 -0.7 -0.7
Worry too long after embarrassment 0.5 0.8 1.8 0.8 1.1 1.4 1.0 0.2 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 1.6 -1.3 -0.2 0.9 -0.6 -1.2 -0.2
Wheeze or whistling in the chest in last year 0.5 0.9 4.0 -2.0 -0.4 -0.3 -0.8 -0.5 -0.0
Number of children fathered 0.5 0.5 2.4 -0.2 0.2 -0.6 0.4 1.6 0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 2.7 -0.3 -0.3 1.6 1.3 1.3 -1.6
Age at first live birth 2.7 4.8 9.7 0.1 -0.1 -3.0 -2.7 -3.1 1.5
Pulse wave peak to peak time 2.7 3.2 4.4 1.5 2.1 -2.0 -0.8 -1.9 2.1
Health satisfaction 1.0 1.3 3.7 -1.9 -1.8 0.1 -0.6 0.3 0.4
Shortness of breath walking on level ground 0.1 0.1 0.3 -0.6 -0.2 0.4 -0.1 0.4 -0.2
Qualifications: College or University degree 2.0 6.2 13.3 -1.1 -0.7 -3.1 -2.1 -3.6 2.9
Eye problems/disorders: None of the above 0.9 1.1 2.5 1.4 0.9 -0.9 -0.0 -0.3 1.6
Mouth/teeth dental problems: Loose teeth 0.8 1.0 1.4 1.2 1.0 0.4 1.1 1.1 -1.0
Emphysema/chronic bronchitis 0.3 0.3 1.6 -0.3 -1.3 0.2 -0.4 0.4 -0.2
Medication for pain relief, constipation, heartburn 1.4 2.3 7.4 2.7 1.4 -0.2 0.2 -2.1 0.3
Neck or shoulder pain in last month 1.2 1.7 5.4 0.7 0.2 0.7 2.3 1.7 -0.8
Medication: Blood pressure 0.6 1.0 2.3 0.3 -1.5 1.1 0.1 1.0 -1.1
Angina (self-reported) 3.0 3.9 6.1 -1.8 -1.3 -2.5 -2.3 -2.4 1.0
Migraine (self-reported) 1.0 1.3 2.2 -0.9 -1.5 -1.3 0.7 1.2 1.1
Medication: Ibuprofen 1.1 1.3 3.4 -1.0 -0.8 0.4 1.5 1.8 -0.7
Medication: Allopurinol 1.5 2.0 6.2 0.3 0.6 2.5 1.0 0.4 -2.1
Medication: Omeprazole 1.3 1.6 3.6 -1.7 -1.9 -1.2 -1.0 -0.7 -0.1
Medication: Seretide 50 evohaler 0.6 0.7 2.7 -0.5 0.2 -0.2 -1.1 -1.6 0.5
Mean time to correctly identify matches 0.4 0.7 2.4 -1.5 -0.8 -0.3 -0.4 -0.5 0.8
Heart disease (mother) 0.9 1.1 2.2 -0.8 -1.0 -0.8 -1.0 -1.0 1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.5 3.8 -1.9 -0.3 0.6 -1.7 -1.3 0.5
Whole body fat mass 1.1 4.4 14.9 0.5 1.9 -2.7 -0.8 -0.2 3.9
Leg fat mass (right) 0.3 1.0 3.8 -0.5 0.7 -0.8 -0.2 0.9 1.9
Arm predicted mass (right) 0.6 3.1 6.9 -0.4 0.4 -2.0 -2.6 -1.8 2.1
Pulse rate, automated reading 0.7 2.4 5.2 1.6 0.1 -0.4 2.2 2.3 1.1
Alcohol intake frequency. 0.9 2.1 4.8 1.9 0.6 0.6 2.2 1.9 -0.4
Comparative height size at age 10 2.1 11.7 19.8 2.5 2.6 -4.5 -2.0 -4.3 3.9
Number of full sisters 0.3 0.4 1.1 0.5 1.0 0.6 0.5 0.0 -0.5
Suffer from ‘nerves’ 0.5 0.9 2.3 0.4 1.3 0.0 0.7 0.6 1.5
Overall health rating 0.5 1.0 2.5 -0.9 -1.0 0.6 1.0 1.6 -0.2
Chest pain or discomfort 2.2 3.2 8.2 -2.9 -1.7 1.6 -0.7 -1.3 -1.8
Had major operations 2.1 2.5 7.3 -1.4 -2.7 -0.9 -2.0 -0.7 0.8
Age at last live birth 1.5 2.1 5.4 -0.0 -0.5 -2.3 -1.7 -1.6 1.3
Family relationship satisfaction 0.6 0.7 1.5 -1.2 -1.0 -0.7 -0.1 1.0 -0.1
Leg pain on walking 0.3 0.4 1.9 -0.1 -0.3 -0.2 0.5 1.4 -0.4
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 1.9 0.7 -0.4 1.2 1.4 1.0 -0.2
Commuting to job workplace: Car/motor vehicle 0.8 0.9 2.7 1.2 -0.2 0.4 1.0 1.6 -0.7
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 3.3 0.9 0.6 1.2 1.8 0.3 -1.8
Medication: Aspirin 0.9 1.2 3.4 -0.7 -1.8 -0.4 -1.7 -0.3 -0.6
Supplements: Vitamin C 1.0 1.2 3.6 -1.1 1.9 0.3 0.5 1.3 -0.2
Knee pain experienced in last month 0.7 1.1 5.1 -0.0 0.6 -0.3 -0.1 2.2 1.1
Hypertension (Self-reported) 1.3 3.5 10.9 -0.1 -1.7 2.3 -0.6 1.3 -3.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 2.1 -0.9 -1.2 1.5 -0.3 0.8 -0.5
Illnesses of father: Heart disease 4.6 6.4 17.0 0.7 -1.5 -3.1 -1.8 -2.4 4.1
Illnesses of siblings: Diabetes 5.0 6.2 11.3 -0.3 1.2 3.1 2.2 3.1 -3.4
Smoking status: Previous 0.4 0.5 2.4 -0.0 0.1 1.5 0.1 -0.4 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 2.7 5.5 11.3 2.7 3.4 -2.7 1.2 -1.1 2.2
Whole body fat-free mass 1.9 10.8 18.3 0.7 1.2 -4.3 -3.7 -3.8 4.1
Leg fat-free mass (right) 3.3 17.5 34.9 1.0 1.5 -5.7 -4.0 -4.3 5.9
Arm fat percentage (left) 0.9 3.7 14.4 -0.2 1.1 -2.4 -0.8 0.4 3.8
Average weekly red wine intake 0.5 0.8 2.9 1.7 0.7 0.7 0.3 -0.5 -0.6
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.9 1.0 -0.9 -0.4 -0.2 -1.4 -0.2
Mood swings 0.6 1.0 3.0 0.4 0.2 -1.5 0.5 -0.6 1.7
Loneliness, isolation 0.8 1.1 5.4 -0.2 0.0 0.5 0.3 2.3 -0.9
Long-standing illness, disability or infirmity 1.8 2.7 8.7 -2.4 -2.9 -0.3 -0.8 0.6 0.9
Ever had bowel cancer screening 0.8 0.9 3.9 -0.0 2.0 -1.2 0.4 0.3 -0.1
Diabetes diagnosed by doctor 4.6 7.6 25.6 -0.5 -0.7 4.0 1.1 1.4 -5.1
Ever had stillbirth, spontaneous miscarriage or termination 3.0 3.2 7.0 0.3 0.6 2.3 1.7 1.9 -2.6
Friendships satisfaction 0.8 1.0 2.5 0.1 -0.8 -1.6 -0.8 1.2 1.1
Qualifications: nursing, teaching 2.8 4.4 8.5 -1.0 -1.1 -2.9 -2.3 -1.2 2.9
Commuting to job workplace: Walk 2.6 2.8 6.2 -1.8 -1.3 -1.1 -2.5 -2.1 0.4
Eye problems/disorders: Cataract 0.4 0.5 1.8 -1.4 0.0 -0.5 0.3 0.9 0.2
Mouth/teeth dental problems: Mouth ulcers 1.7 2.7 5.6 1.7 2.2 0.4 2.4 1.7 0.1
Medication for cholesterol 1.2 1.9 5.6 0.1 0.9 -2.0 -0.5 -0.9 2.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.9 6.4 0.8 2.5 -0.2 1.5 1.4 -0.3
Back pain experienced in last month 1.4 2.1 3.8 -0.3 -0.3 -1.9 -1.8 -1.5 1.6
Mineral and other dietary supplements 0.3 0.4 1.5 0.3 -0.2 -0.3 1.2 0.7 0.1
Breast cancer (self-reported) 1.7 2.1 4.4 1.6 1.6 1.0 2.1 1.4 0.4
Asthma (self-reported) 1.2 2.5 4.7 -0.7 1.2 -2.2 -0.9 -1.7 2.1
Osteoporosis (self-reported) 0.5 0.6 1.5 -1.2 -1.2 0.2 0.5 -0.2 -0.7
Osteoarthritis (self-reported) 0.9 1.2 5.6 -1.1 -0.4 -0.4 0.3 2.4 0.3
Medication: Aspirin 1.8 2.3 6.3 -1.3 -2.5 -0.1 -2.2 -0.3 -0.9
Medication: Gliclazide 2.6 3.0 7.7 0.1 -0.6 2.6 1.6 0.6 -2.8
Illnesses of father: None of the above (group 1) 1.8 2.2 8.0 -0.8 0.6 1.6 0.7 1.0 -2.8
Smoking status: Current 0.8 1.3 3.2 0.5 -0.2 1.1 1.7 1.8 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 2.9 -1.7 -1.3 0.9 -1.0 0.3 0.6
Whole body water mass 1.8 10.4 17.4 0.6 1.0 -4.2 -3.7 -3.7 4.0
Leg predicted mass (right) 3.2 17.3 34.8 1.0 1.5 -5.6 -4.0 -4.3 5.9
Arm fat mass (left) 1.0 4.0 13.7 -0.2 1.1 -2.5 -1.5 -0.4 3.7
Number of self-reported non-cancer illnesses 0.9 1.6 5.1 -2.3 -0.6 -1.1 -0.7 1.5 0.0
Average weekly champagne plus white wine intake 1.5 2.0 5.8 -0.5 -1.3 -0.9 -1.6 -2.4 1.1
Miserableness 0.6 1.1 3.6 0.0 -0.8 -1.9 0.0 -0.8 1.3
Guilty feelings 1.1 1.7 3.0 -1.7 -1.7 0.4 -1.4 -1.5 -0.3
Wears glasses or contact lenses 0.7 0.8 2.2 1.0 1.1 -0.5 0.4 1.5 0.3
Ever taken oral contraceptive pill 1.1 1.3 4.6 -2.1 -0.7 -0.5 -1.1 0.1 -1.0
Hearing aid user 1.5 1.7 3.3 -1.6 0.5 -1.7 -1.8 -0.5 0.9
Mother’s age at death 3.2 4.0 7.3 -1.9 -2.7 -1.1 -2.6 -1.5 1.5
Financial situation satisfaction 1.7 2.1 4.1 -1.6 -0.6 -1.6 -2.0 -1.4 1.1
Tinnitus: Yes, now most or all of the time 1.5 1.7 8.4 0.5 0.0 -0.9 0.5 2.9 0.9
Commuting to job workplace: Public transport 1.4 1.7 3.1 -1.8 -0.4 -1.4 -1.1 -1.5 0.9
Eye problems/disorders: Glaucoma 0.7 0.8 2.2 -0.3 -0.8 -0.4 -1.2 -1.5 0.4
Medication: Blood pressure 3.0 5.8 16.8 0.1 -1.4 3.3 0.8 2.0 -4.1
Pain type(s) experienced in last month: Hip pain 1.1 1.3 2.7 -0.1 -0.3 1.4 1.6 1.6 -0.7
Supplements: Fish oil (including cod liver oil) 0.5 0.7 1.5 -0.7 -0.9 0.4 -1.2 -0.3 -0.9
High cholesterol (Self-reported) 14.4 25.5 64.3 -1.5 -1.1 -8.0 -6.4 -2.9 6.0
Medication: Bendroflumethiazide 0.4 0.7 1.3 0.8 -0.5 0.8 0.5 0.9 -1.1
Medication: Paracetamol 2.0 3.1 5.9 -2.4 -1.3 1.4 0.6 2.3 -1.9
Medication: Lisinopril 0.7 1.0 2.4 -1.6 -1.3 0.0 -1.0 -0.6 0.7
Medication: Atorvastatin 5.7 7.1 16.3 -1.6 -1.1 -4.0 -3.5 -0.6 3.1
Illnesses of father: High blood pressure 0.5 0.6 1.3 -0.8 -0.6 1.1 0.4 1.1 -0.3
Alcohol drinker status: Never 0.3 0.3 0.9 0.1 -0.5 0.9 -0.4 -0.5 -0.6
Ever smoked 0.3 0.5 1.5 0.8 0.2 0.6 -0.4 -1.2 0.8
Basal metabolic rate 1.9 10.3 18.8 0.8 1.4 -4.3 -3.3 -3.4 4.3
Leg fat percentage (left) 0.6 2.2 7.6 -1.8 -0.3 1.2 0.9 2.8 -0.1
Arm fat-free mass (left) 0.7 3.4 6.4 0.1 0.8 -2.3 -2.5 -1.9 2.1
Number of operations (self-reported) 1.0 1.5 2.8 -0.7 -1.1 -1.7 -1.1 -0.5 1.7
Average weekly beer plus cider intake 0.5 0.8 2.8 0.3 -0.2 0.9 1.7 0.4 -0.9
Irritability 3.7 6.2 16.9 1.5 2.8 -4.1 0.4 -0.3 3.2
Risk taking 0.9 1.3 3.2 1.2 1.8 0.2 1.0 0.9 -1.2
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.6 -0.7 -0.4 0.2 -0.8 0.1 0.1
Fractured/broken bones in last 5 years 0.6 0.8 2.6 -1.6 -1.0 0.3 -0.8 0.1 -0.6
Age started oral contraceptive pill 1.1 1.3 4.7 0.5 1.5 -2.2 0.6 -0.1 0.7
Diastolic blood pressure, automated reading 1.5 4.8 14.2 -0.4 -0.4 3.1 0.8 2.0 -3.8
Ever depressed for a whole week 0.4 0.5 1.5 -0.8 0.4 -0.5 -0.2 0.8 1.2
Unable to work because of sickness or disability 0.4 0.5 1.7 -0.2 0.4 0.5 0.5 0.7 -1.3
Commuting to job workplace: Cycle 2.9 3.5 10.1 0.2 1.4 -1.9 -1.5 -3.2 1.8
Myopia 4.6 6.6 13.7 3.2 2.6 2.0 3.7 1.6 -1.6
Vascular/heart problems diagnosed by doctor 0.9 2.5 6.5 0.7 1.8 -1.8 1.1 -0.7 2.5
Cholesterol lowering medication 1.2 1.8 6.6 0.4 -0.7 -2.6 -1.6 -0.4 0.8
Medication: Omeprazole (e.g. Zanprol) 1.1 1.3 3.9 -1.6 -2.0 -0.8 -0.9 -0.1 -0.3
Pain experienced in last month 0.5 0.8 2.2 1.0 -0.2 0.1 -0.9 -1.5 -0.7
Supplements: Calcium 1.1 1.2 2.3 0.3 1.1 0.9 1.5 1.5 -0.8
Basal cell carcinoma (self-reported) 0.2 0.2 0.8 -0.4 0.3 -0.3 -0.5 0.9 0.1
Heart attack/myocardial infarction (self-reported) 1.2 1.5 3.5 1.9 1.0 -1.7 0.8 -0.1 1.0
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.9 -0.3 -0.4 0.1 0.1 -0.2 -0.9
Heart disease (siblings) 2.9 3.6 7.2 -0.6 0.6 -1.8 -2.3 -2.2 2.7
Alcohol drinker status: Previous 0.6 0.6 2.0 -1.1 -0.3 -0.5 0.2 1.4 -0.4
Pack years of smoking 0.9 1.3 2.1 1.0 -0.3 1.2 1.4 1.4 -1.1
Impedance of whole body 2.3 11.9 29.1 4.6 4.2 0.6 5.4 1.9 -0.5
Leg fat mass (left) 0.2 0.9 3.0 -0.7 0.6 -0.8 -0.4 0.8 1.7
Arm predicted mass (left) 0.6 3.1 5.6 0.1 0.9 -2.2 -2.4 -1.8 1.9