TWAS hub - ATP13A1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.1890	0.0940	9.5e-03	0.150	NA	0.039	NA	0.070	1.1e-04	NA	3.6e-02	NA	7.3e-03
2	GTEx	Brain Cerebellum	0.1680	0.0860	7.0e-03	0.030	NA	0.028	NA	0.017	4.6e-02	NA	5.2e-02	NA	1.0e-01
3	GTEx	Cells Transformed fibroblasts	0.1390	0.0630	4.0e-03	0.064	NA	0.028	NA	0.046	1.5e-05	NA	3.4e-03	NA	2.2e-04
4	GTEx	Spleen	0.1590	0.0810	8.9e-03	0.007	NA	0.008	NA	0.021	2.0e-01	NA	1.9e-01	NA	9.7e-02
5	NTR	Blood	0.0129	0.0065	4.4e-03	0.005	0.010	0.007	0.010	0.002	5.8e-03	1.9e-04	2.5e-03	2.8e-04	4.7e-02
6	ROSMAP	Brain Pre-frontal Cortex	0.1014	0.0317	1.2e-06	0.067	0.048	0.042	0.055	0.064	5.4e-09	7.7e-07	4.0e-06	1.3e-07	1.3e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Triglycerides	25.4	41.7	112.4	0.5	2.5	-10.6	-4.5	-6.2	8.5
LDL Cholesterol	19.0	30.0	83.9	0.6	2.1	-9.2	-3.3	-4.3	7.9
High cholesterol (Self-reported)	14.4	25.5	64.3	-1.5	-1.1	-8.0	-6.4	-2.9	6.0
Medication: Cholesterol lowering	14.1	22.0	55.7	-1.2	-1.0	-7.5	-5.2	-3.1	6.1
Blood Platelet Count	7.3	85.2	166.4	4.9	3.7	9.5	11.6	9.1	-12.9
Medication: Simvastatin	7.1	10.5	23.1	0.1	-1.2	-4.8	-4.5	-2.3	3.6
Diabetes (mother)	6.2	7.9	17.0	0.6	0.1	4.1	2.7	3.0	-3.7
Breast Cancer	6.0	14.3	43.7	-3.7	-1.7	-1.9	-6.6	-4.6	0.9
Medication: Atorvastatin	5.7	7.1	16.3	-1.6	-1.1	-4.0	-3.5	-0.6	3.1
Bipolar Disorder or Schizophrenia	5.6	13.6	26.9	5.2	5.0	0.1	5.1	1.9	0.6
Bipolar Disorder (2018)	5.5	8.6	19.4	4.4	4.0	-2.1	2.5	-0.2	2.4
Schizophrenia (2014)	5.5	12.2	24.5	3.8	4.3	2.0	5.0	3.3	-0.9
Sensitivity / hurt feelings	5.0	8.5	17.1	0.9	2.1	2.5	4.1	3.6	-3.1
Illnesses of siblings: Diabetes	5.0	6.2	11.3	-0.3	1.2	3.1	2.2	3.1	-3.4
Illnesses of father: Heart disease	4.6	6.4	17.0	0.7	-1.5	-3.1	-1.8	-2.4	4.1
Diabetes diagnosed by doctor	4.6	7.6	25.6	-0.5	-0.7	4.0	1.1	1.4	-5.1
Myopia	4.6	6.6	13.7	3.2	2.6	2.0	3.7	1.6	-1.6
Birth weight of first child	4.5	8.1	21.4	2.4	1.6	-4.6	-1.1	-1.9	3.8
Type 2 Diabetes (T2D) (2018)	4.3	8.0	20.3	-1.4	-0.7	4.2	1.2	2.5	-4.5
Schizophrenia (2018)	4.2	8.7	20.3	3.1	3.2	1.8	4.5	2.7	-1.2
Prostate Cancer	4.2	5.9	10.5	3.2	3.1	1.1	3.1	2.1	-0.6
Townsend deprivation index at recruitment	4.1	5.7	16.2	-3.2	-4.0	-0.5	-2.2	-0.6	1.4
Mouth/teeth dental problems: Bleeding gums	4.1	5.3	19.3	-4.4	-2.6	-0.4	-2.2	-0.5	-0.6
Diabetes (self-reported)	4.0	6.2	20.4	-0.4	-1.0	3.8	1.0	0.6	-4.5
Serious illness, injury or assault of a close relative in last 2 years	3.9	4.4	9.7	0.3	1.3	-3.1	-1.3	-2.1	3.0
Irritability	3.7	6.2	16.9	1.5	2.8	-4.1	0.4	-0.3	3.2
Impedance of leg (right)	3.5	16.9	38.5	2.6	2.1	4.2	6.2	3.9	-4.4
Impedance of leg (left)	3.5	17.2	37.1	2.3	1.9	4.4	6.1	4.1	-4.6
Comparative body size at age 10	3.5	9.6	23.7	-2.5	-2.4	-1.1	-4.3	-4.9	1.5
Impedance of arm (right)	3.3	15.2	32.9	5.7	5.0	-3.5	3.0	-1.3	3.2
Leg fat-free mass (right)	3.3	17.5	34.9	1.0	1.5	-5.7	-4.0	-4.3	5.9
Type 2 Diabetes (T2D) (2012)	3.2	3.7	10.6	0.0	0.2	3.3	1.7	2.1	-2.0
Pulse wave reflection index	3.2	4.0	10.7	-3.3	-2.8	1.7	-1.4	0.4	-0.6
Leg predicted mass (right)	3.2	17.3	34.8	1.0	1.5	-5.6	-4.0	-4.3	5.9
Mother’s age at death	3.2	4.0	7.3	-1.9	-2.7	-1.1	-2.6	-1.5	1.5
Rheumatoid Arthritis	3.1	4.3	11.3	2.4	1.5	0.6	3.4	2.4	-0.6
Hearing difficulty/problems: Yes	3.1	4.8	12.5	-2.7	-2.5	-0.9	-3.5	-1.0	0.5
Leg fat-free mass (left)	3.1	16.4	32.2	1.2	2.0	-5.5	-3.6	-4.1	5.7
Leg predicted mass (left)	3.1	16.4	32.5	1.2	1.9	-5.5	-3.6	-4.1	5.7
Height	3.0	58.3	110.2	10.5	9.7	-8.3	1.8	-5.5	6.6
Medication: Ramipril	3.0	3.8	7.7	2.5	-0.3	2.3	1.2	1.5	-2.8
Qualifications: A levels/AS levels or equivalent	3.0	6.5	13.2	1.1	0.9	-3.6	-1.2	-3.1	3.6
Angina (self-reported)	3.0	3.9	6.1	-1.8	-1.3	-2.5	-2.3	-2.4	1.0
Ever had stillbirth, spontaneous miscarriage or termination	3.0	3.2	7.0	0.3	0.6	2.3	1.7	1.9	-2.6
Medication: Blood pressure	3.0	5.8	16.8	0.1	-1.4	3.3	0.8	2.0	-4.1
Qualifications: None of the above	2.9	6.1	13.3	-0.7	-0.2	2.9	2.3	3.0	-3.6
Fluid intelligence score	2.9	6.0	17.0	0.6	-0.4	-2.2	-2.4	-2.8	4.1
Prospective memory result	2.9	3.5	7.7	-1.6	-0.1	1.7	1.2	2.5	-2.8
Standing height	2.9	29.2	43.3	6.6	6.3	-6.5	-0.6	-5.0	5.0
Medication: Paracetamol	2.9	4.9	9.8	-2.4	-1.0	2.3	1.4	3.1	-2.3
Commuting to job workplace: Cycle	2.9	3.5	10.1	0.2	1.4	-1.9	-1.5	-3.2	1.8
Heart disease (siblings)	2.9	3.6	7.2	-0.6	0.6	-1.8	-2.3	-2.2	2.7
Coronary Artery Disease (CAD)	2.8	3.4	7.7	-0.7	0.4	-2.5	-2.0	-1.3	2.8
Angina	2.8	3.7	6.0	-1.8	-1.4	-2.3	-2.2	-2.5	1.0
Impedance of arm (left)	2.8	13.1	28.2	5.3	4.7	-2.9	2.8	-1.1	3.2
Qualifications: nursing, teaching	2.8	4.4	8.5	-1.0	-1.1	-2.9	-2.3	-1.2	2.9
Blood Eosinophil Count	2.7	20.7	38.7	4.7	4.0	3.2	6.2	5.2	-3.2
Maternal smoking around birth	2.7	4.0	8.1	1.1	1.2	2.8	2.5	1.5	-2.1
Age at first live birth	2.7	4.8	9.7	0.1	-0.1	-3.0	-2.7	-3.1	1.5
Pulse wave peak to peak time	2.7	3.2	4.4	1.5	2.1	-2.0	-0.8	-1.9	2.1
Forced expiratory volume in 1-second (FEV1), predicted	2.7	5.5	11.3	2.7	3.4	-2.7	1.2	-1.1	2.2
Intelligence (Savage-Jansen 2018)	2.6	7.9	20.2	1.7	1.5	-3.2	-1.3	-3.2	4.5
Sitting height	2.6	18.6	39.3	5.7	6.3	-4.5	1.7	-2.2	3.4
Commuting to job workplace: Walk	2.6	2.8	6.2	-1.8	-1.3	-1.1	-2.5	-2.1	0.4
Medication: Gliclazide	2.6	3.0	7.7	0.1	-0.6	2.6	1.6	0.6	-2.8
Ovarian Cancer	2.5	3.2	6.7	-1.8	-0.8	-2.5	-2.6	-1.6	0.4
Blood Red Count	2.5	24.0	51.0	-5.0	-5.2	6.0	-1.7	1.3	-7.1
Happiness	2.5	3.1	11.4	0.6	-0.2	-2.3	-0.9	-0.5	3.4
Hayfever/allergic rhinitis (self-reported)	2.4	3.2	8.3	-0.6	0.8	-2.9	-0.8	-1.8	2.5
Body Mass Index (BMI) (2010)	2.3	3.2	5.5	-1.7	-1.0	-0.8	-2.3	-2.3	1.9
Time employed in main current job	2.3	2.6	3.8	2.0	-0.2	1.7	1.9	1.9	-1.3
Medication for cholesterol, blood pressure or diabetes	2.3	3.9	7.4	0.6	1.8	2.7	2.7	1.0	-2.0
Impedance of whole body	2.3	11.9	29.1	4.6	4.2	0.6	5.4	1.9	-0.5
Fasting Glucose	2.2	2.7	6.5	-0.4	-0.8	0.6	2.1	1.9	-2.5
Chest pain or discomfort	2.2	3.2	8.2	-2.9	-1.7	1.6	-0.7	-1.3	-1.8
Waist Hip Ratio (WHR)	2.1	9.4	19.8	-2.0	-3.8	4.0	-1.1	-0.3	-4.5
Vitamin and mineral supplements	2.1	2.8	5.9	-0.4	-0.9	-1.7	-2.1	-1.7	2.4
Comparative height size at age 10	2.1	11.7	19.8	2.5	2.6	-4.5	-2.0	-4.3	3.9
Had major operations	2.1	2.5	7.3	-1.4	-2.7	-0.9	-2.0	-0.7	0.8
Crohns Disease (2017)	2.0	4.4	6.5	2.6	1.3	1.7	2.4	2.4	-2.0
Medication: Metformin	2.0	2.8	9.4	-0.6	0.1	2.0	0.8	1.6	-3.1
Pulse rate	2.0	3.4	6.8	1.2	0.0	1.3	2.6	2.6	-1.9
Peak expiratory flow (PEF)	2.0	4.6	14.3	0.2	1.6	-2.3	-1.6	-1.7	3.8
Gout (self-reported)	2.0	2.8	9.2	-0.6	-0.6	3.0	0.8	0.6	-2.4
Qualifications: College or University degree	2.0	6.2	13.3	-1.1	-0.7	-3.1	-2.1	-3.6	2.9
Medication: Paracetamol	2.0	3.1	5.9	-2.4	-1.3	1.4	0.6	2.3	-1.9
Eye problems/disorders: Diabetes related eye disease	1.9	2.0	4.6	-0.9	-1.3	1.9	0.5	1.2	-2.1
Number of live births	1.9	2.7	6.8	-0.6	-0.4	2.6	1.2	1.0	-2.6
Exposure to tobacco smoke at home	1.9	2.1	4.4	0.2	0.7	2.1	1.3	2.1	-1.4
Whole body fat-free mass	1.9	10.8	18.3	0.7	1.2	-4.3	-3.7	-3.8	4.1
Basal metabolic rate	1.9	10.3	18.8	0.8	1.4	-4.3	-3.3	-3.4	4.3
Neuroticism (Nagel 2018)	1.8	4.3	10.2	1.4	3.2	1.2	2.3	2.5	-0.5
Worry (Nagel 2018)	1.8	3.8	11.9	1.5	3.5	0.5	2.0	1.9	0.7
Irritable Bowel Disease (IBD)	1.8	4.2	9.7	2.3	1.4	1.1	2.2	3.1	-1.5
Ever used hormone-replacement therapy (HRT)	1.8	2.2	6.5	-0.8	-0.2	2.5	-0.3	-0.2	-2.6
High blood pressure (mother)	1.8	2.5	8.4	2.1	2.9	0.3	1.1	0.9	-0.5
Trunk fat mass	1.8	7.6	23.5	1.5	2.8	-3.4	-0.3	-0.3	4.8
Qualifications: O levels/GCSEs or equivalent	1.8	2.8	5.9	2.4	2.3	-1.2	1.0	0.1	1.8
Long-standing illness, disability or infirmity	1.8	2.7	8.7	-2.4	-2.9	-0.3	-0.8	0.6	0.9
Medication: Aspirin	1.8	2.3	6.3	-1.3	-2.5	-0.1	-2.2	-0.3	-0.9
Illnesses of father: None of the above (group 1)	1.8	2.2	8.0	-0.8	0.6	1.6	0.7	1.0	-2.8
Whole body water mass	1.8	10.4	17.4	0.6	1.0	-4.2	-3.7	-3.7	4.0
Taking other prescription medications	1.7	2.7	7.4	-0.6	0.4	0.7	2.7	2.7	-0.5
Stomach or abdominal pain in last month	1.7	2.1	4.0	-1.7	0.2	0.9	2.0	1.6	-1.6
Hair/balding pattern: Pattern 2	1.7	2.2	7.2	-0.1	0.1	1.5	1.8	2.7	-0.5
Pulse wave Arterial Stiffness index	1.7	2.0	3.0	-0.9	-1.7	1.6	0.9	1.4	-1.7
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	5.6	1.7	2.2	0.4	2.4	1.7	0.1
Breast cancer (self-reported)	1.7	2.1	4.4	1.6	1.6	1.0	2.1	1.4	0.4
Financial situation satisfaction	1.7	2.1	4.1	-1.6	-0.6	-1.6	-2.0	-1.4	1.1
Trunk fat percentage	1.6	6.2	19.9	1.5	2.8	-2.7	0.6	0.6	4.5
Medication: Levothyroxine sodium	1.6	2.7	7.6	2.3	1.1	1.0	2.8	0.4	-0.9
Hip circumference	1.6	6.8	22.7	0.8	2.3	-3.4	-1.1	-0.3	4.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	6.4	0.8	2.5	-0.2	1.5	1.4	-0.3
HbA1C	1.5	1.6	5.2	-1.4	-1.1	0.6	-0.1	2.3	-1.0
Number of treatments/medications taken	1.5	2.7	9.6	-3.1	-1.7	0.4	-0.2	1.3	-1.4
Weight	1.5	7.2	18.2	1.0	1.8	-3.8	-1.9	-1.6	4.3
Asthma	1.5	2.9	5.9	-0.8	1.1	-2.4	-1.1	-1.7	2.3
Medication: Lansoprazole	1.5	1.7	3.6	-1.0	-1.4	1.9	0.8	1.3	-1.2
Illnesses of mother	1.5	1.8	5.3	-0.5	-0.3	-1.3	-1.3	-2.3	1.4
Hypothyroidism/myxoedema (self-reported)	1.5	2.9	9.2	1.9	1.9	1.0	3.0	-0.1	-0.1
Forced vital capacity (FVC), Best measure	1.5	5.6	11.2	1.6	1.4	-3.3	-1.3	-2.3	3.3
Medication: Allopurinol	1.5	2.0	6.2	0.3	0.6	2.5	1.0	0.4	-2.1
Age at last live birth	1.5	2.1	5.4	-0.0	-0.5	-2.3	-1.7	-1.6	1.3
Average weekly champagne plus white wine intake	1.5	2.0	5.8	-0.5	-1.3	-0.9	-1.6	-2.4	1.1
Hearing aid user	1.5	1.7	3.3	-1.6	0.5	-1.7	-1.8	-0.5	0.9
Tinnitus: Yes, now most or all of the time	1.5	1.7	8.4	0.5	0.0	-0.9	0.5	2.9	0.9
Diastolic blood pressure, automated reading	1.5	4.8	14.2	-0.4	-0.4	3.1	0.8	2.0	-3.8
Blood White Count	1.4	10.3	27.2	1.3	-0.2	3.9	3.4	2.5	-5.2
Heel T-Score	1.4	10.8	18.7	-1.0	-0.5	4.3	3.5	3.8	-4.3
Systolic Blood Pressure	1.4	6.9	22.2	2.3	1.0	2.9	1.8	1.1	-4.7
Hypothyroidism (self reported)	1.4	3.1	6.6	2.2	2.6	-0.3	2.3	-1.4	0.4
Trunk fat-free mass	1.4	7.9	12.6	0.6	1.0	-3.5	-3.5	-3.5	3.0
Falls in the last year	1.4	1.9	6.5	1.3	0.4	-0.3	1.7	2.5	0.3
Medication for pain relief, constipation, heartburn	1.4	2.3	7.4	2.7	1.4	-0.2	0.2	-2.1	0.3
Back pain experienced in last month	1.4	2.1	3.8	-0.3	-0.3	-1.9	-1.8	-1.5	1.6
Commuting to job workplace: Public transport	1.4	1.7	3.1	-1.8	-0.4	-1.4	-1.1	-1.5	0.9
Schizophrenia vs Biploar Disorder	1.3	1.8	5.5	-0.3	0.1	1.4	1.4	2.4	-1.1
Verbal and Numeric Reasoning (VNR)	1.3	3.2	8.8	0.8	0.3	-1.9	-1.5	-2.0	3.0
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.1	6.7	-0.4	0.1	2.6	1.6	2.5	-1.6
Forced vital capacity (FVC)	1.3	4.8	10.3	1.2	1.4	-3.2	-1.0	-2.4	3.0
Mouth/teeth dental problems	1.3	2.0	6.9	2.6	1.5	-0.7	0.3	-1.1	1.1
Alcohol intake versus 10 years previously	1.3	2.0	3.8	1.0	0.6	1.3	1.9	1.3	-1.9
Trunk predicted mass	1.3	7.7	12.5	0.6	0.9	-3.5	-3.4	-3.5	2.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	1.9	4.9	-0.3	0.6	-2.1	-1.2	-0.5	2.2
Birth weight	1.3	2.7	6.0	0.2	1.1	-2.5	-0.9	-2.0	2.0
Medication: Omeprazole	1.3	1.6	3.6	-1.7	-1.9	-1.2	-1.0	-0.7	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	3.8	-1.9	-0.3	0.6	-1.7	-1.3	0.5
Hypertension (Self-reported)	1.3	3.5	10.9	-0.1	-1.7	2.3	-0.6	1.3	-3.3
Major Depression (MDD)	1.2	1.5	4.1	0.6	0.7	-1.2	-1.1	-1.1	2.0
Ever had hysterectomy (womb removed)	1.2	1.4	3.1	1.1	0.2	-1.8	0.8	-0.3	1.8
Pack years adult smoking proportion	1.2	1.8	3.0	1.1	-0.3	1.6	1.7	1.6	-1.2
Depression (self-reported)	1.2	1.4	3.1	-1.8	0.2	-1.5	-1.4	-0.3	1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.7	-0.3	-0.3	1.6	1.3	1.3	-1.6
Neck or shoulder pain in last month	1.2	1.7	5.4	0.7	0.2	0.7	2.3	1.7	-0.8
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	3.3	0.9	0.6	1.2	1.8	0.3	-1.8
Medication for cholesterol	1.2	1.9	5.6	0.1	0.9	-2.0	-0.5	-0.9	2.4
Asthma (self-reported)	1.2	2.5	4.7	-0.7	1.2	-2.2	-0.9	-1.7	2.1
Cholesterol lowering medication	1.2	1.8	6.6	0.4	-0.7	-2.6	-1.6	-0.4	0.8
Heart attack/myocardial infarction (self-reported)	1.2	1.5	3.5	1.9	1.0	-1.7	0.8	-0.1	1.0
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	4.4	-0.9	-2.1	-1.5	-0.7	-0.2	0.7
Severe depression (siblings)	1.1	1.2	3.8	0.7	1.0	-0.8	2.0	0.9	0.4
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.7	-1.6	-0.4	-1.4	-1.0	-0.3	1.3
Medication: Atenolol	1.1	1.4	3.6	0.1	-1.1	1.5	-0.4	-1.1	-1.9
Nervous feelings	1.1	2.0	5.7	1.0	2.4	-1.1	0.8	1.4	1.3
Heart attack	1.1	1.4	3.6	1.9	0.9	-1.5	1.0	-0.1	0.8
Hair/balding pattern: Pattern 3	1.1	1.6	4.0	-0.7	-0.3	-2.0	-1.4	-1.1	1.3
Medication: Ibuprofen	1.1	1.3	3.4	-1.0	-0.8	0.4	1.5	1.8	-0.7
Whole body fat mass	1.1	4.4	14.9	0.5	1.9	-2.7	-0.8	-0.2	3.9
Guilty feelings	1.1	1.7	3.0	-1.7	-1.7	0.4	-1.4	-1.5	-0.3
Ever taken oral contraceptive pill	1.1	1.3	4.6	-2.1	-0.7	-0.5	-1.1	0.1	-1.0
Pain type(s) experienced in last month: Hip pain	1.1	1.3	2.7	-0.1	-0.3	1.4	1.6	1.6	-0.7
Age started oral contraceptive pill	1.1	1.3	4.7	0.5	1.5	-2.2	0.6	-0.1	0.7
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.9	-1.6	-2.0	-0.8	-0.9	-0.1	-0.3
Supplements: Calcium	1.1	1.2	2.3	0.3	1.1	0.9	1.5	1.5	-0.8
BMI	1.0	5.8	13.7	-3.7	-1.5	-1.9	-2.6	0.2	3.0
Average weekly fortified wine intake	1.0	1.2	3.2	-1.2	-1.2	1.8	-0.3	0.3	-1.0
Relative age voice broke	1.0	1.5	6.6	1.0	2.6	0.6	0.1	-1.0	0.0
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	4.5	0.7	2.1	0.4	0.4	-0.9	0.1
Multivitamins +/- minerals	1.0	1.3	3.4	0.2	-0.3	1.0	1.0	1.5	-1.9
Alcohol usually taken with meals	1.0	1.7	4.0	1.3	0.9	2.0	0.8	0.3	-1.7
Had menopause	1.0	1.3	3.7	-1.0	-1.1	1.9	-0.6	0.2	-1.2
Allergy	1.0	2.3	9.0	-0.2	-0.7	3.0	0.1	0.3	-2.1
Illnesses of siblings	1.0	1.4	3.6	1.5	-0.5	-1.9	0.2	-0.3	1.6
Mouth/teeth dental problems: Dentures	1.0	1.7	4.5	-1.4	-1.3	1.4	0.3	0.5	-2.1
Lung cancer (father)	1.0	1.2	4.2	-0.4	0.1	0.3	0.7	1.4	-2.1
Health satisfaction	1.0	1.3	3.7	-1.9	-1.8	0.1	-0.6	0.3	0.4
Migraine (self-reported)	1.0	1.3	2.2	-0.9	-1.5	-1.3	0.7	1.2	1.1
Supplements: Vitamin C	1.0	1.2	3.6	-1.1	1.9	0.3	0.5	1.3	-0.2
Arm fat mass (left)	1.0	4.0	13.7	-0.2	1.1	-2.5	-1.5	-0.4	3.7
Number of operations (self-reported)	1.0	1.5	2.8	-0.7	-1.1	-1.7	-1.1	-0.5	1.7
Ulcerative Colitis (UC)	0.9	1.7	4.8	1.5	1.4	-0.2	1.1	2.2	-0.1
Mean Putamen Volume	0.9	1.0	2.3	1.5	0.9	0.8	0.9	0.3	-1.3
Neuroticism	0.9	2.2	7.7	1.0	2.8	0.1	1.6	1.2	0.5
Frequency of depressed mood in last 2 weeks	0.9	1.2	2.2	-0.7	-0.5	-1.1	-1.5	-1.4	1.1
Diabetes (father)	0.9	1.1	2.6	-0.1	-0.7	1.6	1.2	0.9	-1.2
High blood pressure	0.9	2.6	7.9	-0.3	-1.4	2.0	-0.9	0.9	-2.8
Pain all over the body in last month	0.9	1.0	3.3	-0.8	-0.1	0.8	-0.0	1.8	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	7.4	0.9	0.9	-2.0	-1.2	-1.6	2.7
Arm fat mass (right)	0.9	3.5	11.5	-0.2	1.1	-2.5	-1.4	-0.3	3.4
Breastfed as a baby	0.9	1.1	4.6	2.1	-0.1	0.6	0.8	-1.1	-0.0
Headache pain in last month	0.9	1.6	8.0	-0.6	0.2	-0.1	2.8	1.1	-0.0
Eye problems/disorders: None of the above	0.9	1.1	2.5	1.4	0.9	-0.9	-0.0	-0.3	1.6
Heart disease (mother)	0.9	1.1	2.2	-0.8	-1.0	-0.8	-1.0	-1.0	1.5
Alcohol intake frequency.	0.9	2.1	4.8	1.9	0.6	0.6	2.2	1.9	-0.4
Medication: Aspirin	0.9	1.2	3.4	-0.7	-1.8	-0.4	-1.7	-0.3	-0.6
Arm fat percentage (left)	0.9	3.7	14.4	-0.2	1.1	-2.4	-0.8	0.4	3.8
Osteoarthritis (self-reported)	0.9	1.2	5.6	-1.1	-0.4	-0.4	0.3	2.4	0.3
Number of self-reported non-cancer illnesses	0.9	1.6	5.1	-2.3	-0.6	-1.1	-0.7	1.5	0.0
Risk taking	0.9	1.3	3.2	1.2	1.8	0.2	1.0	0.9	-1.2
Vascular/heart problems diagnosed by doctor	0.9	2.5	6.5	0.7	1.8	-1.8	1.1	-0.7	2.5
Pack years of smoking	0.9	1.3	2.1	1.0	-0.3	1.2	1.4	1.4	-1.1
Crohns Disease (2012)	0.8	1.2	3.0	1.1	1.1	-0.2	1.1	1.7	-0.8
Neuroticism (2016)	0.8	1.2	2.3	-1.4	-0.3	0.9	1.3	1.5	-0.5
Current tobacco smoking	0.8	1.3	3.5	0.6	-0.6	0.9	1.6	1.9	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	3.8	-0.2	-0.1	1.6	0.2	0.3	-2.0
Serious illness, injury or assault to yourself	0.8	0.9	3.3	-0.5	0.3	-1.0	-0.7	-0.6	1.8
Supplements: Glucosamine	0.8	1.0	2.4	0.4	1.5	-1.2	-0.7	-0.9	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.4	-1.5	-1.1	-0.3	-1.5	-1.3	0.7
Hearing difficulty/problems with background noise	0.8	1.3	3.3	-0.7	-1.8	0.5	-0.8	1.3	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	5.3	-0.7	0.4	2.3	1.1	1.5	-1.3
Financial difficulties in last 2 years	0.8	1.1	2.5	-1.6	-1.1	-0.8	-1.3	0.8	0.2
Arm fat percentage (right)	0.8	3.3	12.2	0.1	1.1	-2.4	-0.7	0.4	3.5
Noisy workplace	0.8	0.9	2.0	1.0	0.9	-1.4	0.1	-0.0	1.3
Loud music exposure frequency	0.8	0.9	2.2	-0.3	1.5	-1.3	-0.1	-0.3	1.2
Medication: Amlodipine	0.8	1.1	3.9	-0.1	-0.7	0.5	-2.0	-1.2	-0.6
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.7	-0.7	-1.4	0.4	-0.4	1.6	-0.5
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.4	1.2	1.0	0.4	1.1	1.1	-1.0
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.7	1.2	-0.2	0.4	1.0	1.6	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.1	-0.9	-1.2	1.5	-0.3	0.8	-0.5
Loneliness, isolation	0.8	1.1	5.4	-0.2	0.0	0.5	0.3	2.3	-0.9
Ever had bowel cancer screening	0.8	0.9	3.9	-0.0	2.0	-1.2	0.4	0.3	-0.1
Friendships satisfaction	0.8	1.0	2.5	0.1	-0.8	-1.6	-0.8	1.2	1.1
Smoking status: Current	0.8	1.3	3.2	0.5	-0.2	1.1	1.7	1.8	-0.4
Age at First Birth	0.7	1.0	1.8	0.9	1.1	-0.9	-0.5	-1.0	1.3
Medication for hormone replacement therapy	0.7	0.8	2.1	0.2	-0.6	1.5	0.5	-1.0	-0.8
Supplements: Zinc	0.7	0.8	1.6	0.7	1.3	-0.8	0.4	0.3	1.3
Medication: Co-codamol	0.7	0.8	3.9	0.0	0.4	0.6	2.0	-0.0	-0.6
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.3	1.0	1.5	-0.0	0.4	-0.6	1.0
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.4	-1.1	-0.7	-0.6	-1.0	0.8	1.2
Father’s age at death	0.7	1.0	3.0	1.7	1.5	0.1	0.2	-0.2	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.1	-1.0	-0.6	1.4	1.1	1.1	-0.9
Length of working week for main job	0.7	0.8	1.5	0.2	0.9	-1.1	1.0	0.5	1.2
Ever highly irritable/argumentative for 2 days	0.7	0.8	3.2	-0.5	0.4	0.0	0.8	1.8	-0.8
Body fat percentage	0.7	2.7	9.1	0.3	1.6	-1.4	0.5	1.3	3.0
Arm fat-free mass (right)	0.7	3.4	7.8	-0.3	0.6	-2.1	-2.8	-1.8	2.1
Pulse rate, automated reading	0.7	2.4	5.2	1.6	0.1	-0.4	2.2	2.3	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.9	0.7	-0.4	1.2	1.4	1.0	-0.2
Knee pain experienced in last month	0.7	1.1	5.1	-0.0	0.6	-0.3	-0.1	2.2	1.1
Wears glasses or contact lenses	0.7	0.8	2.2	1.0	1.1	-0.5	0.4	1.5	0.3
Eye problems/disorders: Glaucoma	0.7	0.8	2.2	-0.3	-0.8	-0.4	-1.2	-1.5	0.4
Medication: Lisinopril	0.7	1.0	2.4	-1.6	-1.3	0.0	-1.0	-0.6	0.7
Arm fat-free mass (left)	0.7	3.4	6.4	0.1	0.8	-2.3	-2.5	-1.9	2.1
Alzheimer’s Disease (in mother)	0.6	0.6	2.6	0.7	0.2	0.4	1.6	0.4	-0.6
Reaction Time	0.6	1.2	3.1	-1.3	-0.6	-1.1	-0.1	-0.8	1.8
Ulcerative Colitis	0.6	0.8	3.8	-0.0	0.8	0.3	-0.2	1.9	-0.4
Cardiovascular Disease	0.6	2.0	7.1	-1.4	-1.6	-0.0	-2.7	-0.2	-0.7
Lung FEV1/FVC ratio	0.6	3.1	6.1	-1.2	-1.8	2.5	0.3	2.4	-1.5
Systolic blood pressure, automated reading	0.6	1.9	6.3	1.6	1.1	0.9	0.5	0.1	-2.5
Number of incorrect matches in round	0.6	1.0	3.6	-1.9	-0.2	0.8	0.2	1.1	-0.9
Neuroticism score	0.6	1.2	2.9	0.7	1.2	-1.2	0.9	0.5	1.7
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	4.5	0.9	1.0	-1.6	-0.6	-1.7	2.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.2	-0.0	0.1	-0.5	1.3	1.5	0.6
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.4	-1.2	0.4	-0.9	0.6	-0.9	1.0
Leg fat percentage (right)	0.6	2.1	7.9	-1.4	-0.0	1.1	1.2	2.8	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.6	-1.3	-0.2	0.9	-0.6	-1.2	-0.2
Medication: Blood pressure	0.6	1.0	2.3	0.3	-1.5	1.1	0.1	1.0	-1.1
Medication: Seretide 50 evohaler	0.6	0.7	2.7	-0.5	0.2	-0.2	-1.1	-1.6	0.5
Arm predicted mass (right)	0.6	3.1	6.9	-0.4	0.4	-2.0	-2.6	-1.8	2.1
Family relationship satisfaction	0.6	0.7	1.5	-1.2	-1.0	-0.7	-0.1	1.0	-0.1
Mood swings	0.6	1.0	3.0	0.4	0.2	-1.5	0.5	-0.6	1.7
Miserableness	0.6	1.1	3.6	0.0	-0.8	-1.9	0.0	-0.8	1.3
Leg fat percentage (left)	0.6	2.2	7.6	-1.8	-0.3	1.2	0.9	2.8	-0.1
Fractured/broken bones in last 5 years	0.6	0.8	2.6	-1.6	-1.0	0.3	-0.8	0.1	-0.6
Alcohol drinker status: Previous	0.6	0.6	2.0	-1.1	-0.3	-0.5	0.2	1.4	-0.4
Arm predicted mass (left)	0.6	3.1	5.6	0.1	0.9	-2.2	-2.4	-1.8	1.9
Allergy or Eczema	0.5	1.3	3.4	0.7	0.6	-1.8	0.9	0.7	1.6
Average weekly spirits intake	0.5	0.6	2.6	-1.6	0.5	-0.1	0.5	0.6	0.4
Fed-up feelings	0.5	0.9	2.7	-0.2	0.2	0.4	1.6	1.6	-0.1
Age when periods started (menarche)	0.5	1.3	2.4	1.0	1.3	0.4	1.6	1.3	-0.7
Body mass index (BMI)	0.5	2.1	4.8	-2.2	-1.1	-0.6	-1.7	0.7	1.8
Waist circumference	0.5	1.7	4.2	-1.3	-0.9	-0.8	-2.0	-0.0	1.7
Worrier / anxious feelings	0.5	1.0	3.6	-0.4	0.2	0.2	1.9	1.5	0.1
Worry too long after embarrassment	0.5	0.8	1.8	0.8	1.1	1.4	1.0	0.2	-0.3
Wheeze or whistling in the chest in last year	0.5	0.9	4.0	-2.0	-0.4	-0.3	-0.8	-0.5	-0.0
Number of children fathered	0.5	0.5	2.4	-0.2	0.2	-0.6	0.4	1.6	0.3
Suffer from ‘nerves’	0.5	0.9	2.3	0.4	1.3	0.0	0.7	0.6	1.5
Overall health rating	0.5	1.0	2.5	-0.9	-1.0	0.6	1.0	1.6	-0.2
Average weekly red wine intake	0.5	0.8	2.9	1.7	0.7	0.7	0.3	-0.5	-0.6
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.9	1.0	-0.9	-0.4	-0.2	-1.4	-0.2
Osteoporosis (self-reported)	0.5	0.6	1.5	-1.2	-1.2	0.2	0.5	-0.2	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.9	-1.7	-1.3	0.9	-1.0	0.3	0.6
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.5	-0.7	-0.9	0.4	-1.2	-0.3	-0.9
Illnesses of father: High blood pressure	0.5	0.6	1.3	-0.8	-0.6	1.1	0.4	1.1	-0.3
Average weekly beer plus cider intake	0.5	0.8	2.8	0.3	-0.2	0.9	1.7	0.4	-0.9
Pain experienced in last month	0.5	0.8	2.2	1.0	-0.2	0.1	-0.9	-1.5	-0.7
Depressed Affect (Nagel 2018)	0.4	0.8	2.1	-0.1	0.9	0.8	1.1	1.4	-0.3
Alzheimer’s Disease (in father)	0.4	0.4	0.9	-0.7	-0.0	-1.0	-0.8	0.6	0.3
Smoking Status	0.4	0.9	2.5	0.3	-0.2	1.6	1.4	0.6	-0.6
Respiratory disease	0.4	0.9	1.1	-1.0	0.8	-1.0	-0.9	-0.9	1.1
Hand grip strength (left)	0.4	1.0	3.8	0.9	0.9	-0.3	-0.2	-2.0	0.6
Hayfever, allergic rhinitis or eczema	0.4	0.8	3.8	0.2	0.5	-1.9	0.2	-0.3	0.9
High blood pressure (siblings)	0.4	0.6	1.9	-0.5	0.4	1.1	-0.4	-0.3	-1.4
Number of full brothers	0.4	0.5	1.6	1.3	-0.2	0.3	0.7	-0.7	-0.7
Mean time to correctly identify matches	0.4	0.7	2.4	-1.5	-0.8	-0.3	-0.4	-0.5	0.8
Smoking status: Previous	0.4	0.5	2.4	-0.0	0.1	1.5	0.1	-0.4	-0.9
Eye problems/disorders: Cataract	0.4	0.5	1.8	-1.4	0.0	-0.5	0.3	0.9	0.2
Medication: Bendroflumethiazide	0.4	0.7	1.3	0.8	-0.5	0.8	0.5	0.9	-1.1
Ever depressed for a whole week	0.4	0.5	1.5	-0.8	0.4	-0.5	-0.2	0.8	1.2
Unable to work because of sickness or disability	0.4	0.5	1.7	-0.2	0.4	0.5	0.5	0.7	-1.3
Alzheimer’s Disease (including proxy)	0.3	0.4	1.1	0.2	0.5	-0.1	1.0	0.9	-0.4
Lupus	0.3	0.5	1.8	1.3	0.4	-0.9	0.2	-0.4	-0.1
Primary Biliary Cirrhosis	0.3	0.4	1.2	-0.3	0.4	1.0	-1.1	0.1	-0.4
Chronotype (morning person)	0.3	0.7	2.0	0.1	-1.4	0.5	-1.2	-0.6	-0.4
Relative age of first facial hair	0.3	0.6	2.5	-0.3	0.3	1.6	0.0	0.5	-0.7
Hand grip strength (right)	0.3	0.8	4.2	0.1	0.2	0.1	-0.5	-2.0	-0.5
Chronic bronchitis/emphysema (father)	0.3	0.4	1.0	0.5	0.4	-0.0	-0.5	-1.0	0.7
Emphysema/chronic bronchitis	0.3	0.3	1.6	-0.3	-1.3	0.2	-0.4	0.4	-0.2
Leg fat mass (right)	0.3	1.0	3.8	-0.5	0.7	-0.8	-0.2	0.9	1.9
Number of full sisters	0.3	0.4	1.1	0.5	1.0	0.6	0.5	0.0	-0.5
Leg pain on walking	0.3	0.4	1.9	-0.1	-0.3	-0.2	0.5	1.4	-0.4
Mineral and other dietary supplements	0.3	0.4	1.5	0.3	-0.2	-0.3	1.2	0.7	0.1
Alcohol drinker status: Never	0.3	0.3	0.9	0.1	-0.5	0.9	-0.4	-0.5	-0.6
Ever smoked	0.3	0.5	1.5	0.8	0.2	0.6	-0.4	-1.2	0.8
Depression (Nagel 2018)	0.2	0.3	1.0	-1.0	-0.1	0.5	-0.6	-0.6	-0.3
Qualifications: CSEs or equivalent	0.2	0.3	0.7	-0.2	0.7	0.4	-0.3	0.8	-0.3
Past tobacco smoking	0.2	0.4	1.1	-0.7	-0.6	-1.1	-0.2	0.7	0.1
Tense / ‘highly strung’	0.2	0.4	0.8	0.1	0.9	-0.4	0.5	0.7	0.8
Blood clot in the leg (DVT)	0.2	0.3	1.4	-0.4	-0.2	0.5	0.0	-0.1	-1.2
Glaucoma (self-reported)	0.2	0.2	0.6	-0.3	-0.4	0.2	-0.8	-0.8	-0.0
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	-0.7	-0.4	0.2	-0.8	0.1	0.1
Basal cell carcinoma (self-reported)	0.2	0.2	0.8	-0.4	0.3	-0.3	-0.5	0.9	0.1
Leg fat mass (left)	0.2	0.9	3.0	-0.7	0.6	-0.8	-0.4	0.8	1.7
HDL Cholesterol	0.1	0.2	0.6	0.8	-0.2	0.4	0.0	-0.6	0.5
Lung FVC	0.1	0.3	1.0	-0.4	-0.5	0.2	0.0	0.6	1.0
Hair Pigment	0.1	2.4	6.2	-0.5	-1.3	2.5	-0.2	1.4	-2.0
Hair/balding pattern: Pattern 4	0.1	0.3	0.5	-0.3	-0.7	-0.4	-0.7	-0.4	-0.4
Exposure to tobacco smoke outside home	0.1	0.1	0.4	-0.6	0.5	0.1	-0.4	-0.0	0.2
Shortness of breath walking on level ground	0.1	0.1	0.3	-0.6	-0.2	0.4	-0.1	0.4	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.9	-0.3	-0.4	0.1	0.1	-0.2	-0.9
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Tanning	0.0	0.3	1.3	-0.4	-0.0	-0.1	-0.3	0.2	1.1
Had other major operations	0.0	0.1	0.1	0.3	0.0	-0.4	-0.2	0.1	0.1

Hub : Genes

ATP13A1

Models

Trait associations