[Hub]/) : Traits : Leg fat-free mass (right) :

chr22:38,787,166-41,004,384

Best TWAS P=9.01e-09 · Best GWAS P=1.61e-09 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous MGAT3 0.08 0.04 lasso 4 0.04 4.3e-04 -5.7 5.2 1.7e-07 0.04 0.01 0.98 FALSE
2 GTEx Heart Atrial Appendage MGAT3 0.14 0.14 lasso 2 0.12 3.5e-06 -5.5 5.6 2.5e-08 0.02 0.01 0.98 FALSE
3 GTEx Nerve Tibial SYNGR1 0.26 0.18 enet 27 0.21 3.6e-15 -4.2 -5.2 1.6e-07 -0.04 0.06 0.94 FALSE
4 GTEx Pituitary APOBEC3G 0.34 0.04 enet 11 0.11 1.2e-03 4.6 5.2 1.8e-07 0.04 0.15 0.10 TRUE
5 GTEx Skin Sun Exposed Lower leg MGAT3 0.13 0.05 lasso 3 0.02 4.7e-03 -5.5 5.6 1.7e-08 0.01 0.01 0.98 TRUE
6 The Cancer Genome Atlas Breast Invasive Carcinoma TNRC6B 0.02 0.01 blup 92 0.01 2.7e-03 -4.0 -5.1 2.9e-07 0.82 0.02 0.77 FALSE
7 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ADSL 0.04 0.03 enet 6 0.03 1.6e-04 -5.9 -5.4 8.3e-08 0.86 0.00 0.94 FALSE
8 The Cancer Genome Atlas Lung Adenocarcinoma ADSL 0.03 0.00 blup 33 0.01 8.9e-03 -5.7 -5.4 8.3e-08 0.82 0.01 0.62 FALSE
9 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma ADSL 0.06 0.02 lasso 2 0.03 6.6e-03 -5.8 -5.8 9.0e-09 0.97 0.00 0.82 TRUE
10 The Cancer Genome Atlas Pancreatic Adenocarcinoma ADSL 0.09 0.03 lasso 3 0.01 7.7e-02 -5.9 -5.7 1.3e-08 0.91 0.00 0.76 FALSE