[Hub]/) : Traits : Leg fat-free mass (right) : ← →

chr4:122,028,784-124,538,705

Best TWAS P=9.24e-19 · Best GWAS P=2.41e-13 conditioned to 0.13

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
26	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CCNA2	0.03	0.01	blup	34	0.02	1.5e-03	-7.03	8.8	9.2e-19	0.02	0.00	0.97	TRUE
13	GTEx	Muscle Skeletal	NUDT6	0.15	0.12	lasso	3	0.11	1.1e-10	5.87	5.9	3.2e-09	0.74	0.96	0.04	TRUE
12	GTEx	Colon Transverse	BBS12	0.12	0.05	enet	29	0.12	3.2e-06	0.49	5.4	6.2e-08	0.48	0.04	0.59	TRUE
3	GTEx	Artery Tibial	FGF2	0.18	0.05	lasso	3	0.02	1.3e-02	5.22	5.4	7.6e-08	0.36	0.08	0.11	TRUE
31	The Cancer Genome Atlas	Thyroid Carcinoma	EXOSC9	0.04	0.05	lasso	2	0.04	7.1e-05	6.81	7.6	2.9e-14	0.03	0.02	0.96	FALSE
11	GTEx	Cells Transformed fibroblasts	BBS7	0.16	0.09	lasso	7	0.16	2.9e-12	-7.16	-7.5	4.3e-14	-0.03	0.00	1.00	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	EXOSC9	0.03	0.04	enet	9	0.04	2.8e-08	6.81	7.5	8.2e-14	0.02	0.06	0.94	FALSE
1	CommonMind	Brain Pre-frontal Cortex	BBS7	0.19	0.21	bslmm	423	0.23	1.8e-27	-7.06	-7.5	9.2e-14	-0.01	0.00	1.00	FALSE
18	GTEx	Testis	EXOSC9	0.17	0.07	lasso	8	0.10	2.5e-05	-5.43	7.2	8.3e-13	0.04	0.02	0.98	FALSE
27	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	BBS7	0.04	0.04	lasso	2	0.03	6.1e-04	-7.06	-7.1	1.5e-12	-0.03	0.00	0.99	FALSE
25	The Cancer Genome Atlas	Colon Adenocarcinoma	BBS7	0.05	0.00	blup	47	0.02	1.9e-02	6.86	-7.0	2.0e-12	-0.03	0.02	0.26	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	EXOSC9	0.29	0.17	lasso	7	0.16	6.6e-06	6.38	7.0	2.3e-12	0.01	0.18	0.80	FALSE
21	YFS	Blood	EXOSC9	0.06	0.09	bslmm	401	0.09	7.0e-28	6.37	6.9	5.7e-12	0.00	0.27	0.73	FALSE
29	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EXOSC9	0.03	0.02	lasso	2	0.02	1.0e-03	6.34	6.8	8.2e-12	0.01	0.06	0.50	FALSE
14	GTEx	Muscle Skeletal	RP11-170N16.3	0.07	0.07	lasso	3	0.06	8.8e-07	5.28	5.9	3.2e-09	0.74	0.24	0.75	FALSE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FGF2	0.06	0.04	blup	65	0.05	4.4e-06	6.21	5.9	4.1e-09	0.85	0.01	0.98	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NUDT6	0.04	0.04	lasso	3	0.02	6.5e-04	5.87	5.9	4.8e-09	0.74	0.70	0.05	FALSE
17	GTEx	Skin Sun Exposed Lower leg	NUDT6	0.11	0.08	lasso	3	0.08	6.2e-07	5.76	5.8	7.4e-09	0.70	0.93	0.04	FALSE
7	GTEx	Breast Mammary Tissue	NUDT6	0.25	0.10	lasso	3	0.08	4.2e-05	5.72	5.8	9.1e-09	0.83	0.08	0.88	FALSE
8	GTEx	Breast Mammary Tissue (Male)	NUDT6	0.29	0.00	lasso	6	0.00	3.5e-01	5.76	5.7	1.0e-08	0.74	0.04	0.43	FALSE
4	GTEx	Artery Tibial	NUDT6	0.08	0.08	lasso	5	0.05	5.6e-05	5.71	5.7	1.2e-08	0.73	0.64	0.10	FALSE
6	GTEx	Brain Cerebellum	BBS7	0.20	-0.01	enet	24	0.01	2.2e-01	-5.37	-5.7	1.2e-08	-0.03	0.07	0.72	FALSE
23	The Cancer Genome Atlas	Breast Invasive Carcinoma	NUDT6	0.02	0.02	lasso	4	0.01	5.4e-03	5.71	5.7	1.3e-08	0.72	0.13	0.15	FALSE
24	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CCNA2	0.11	-0.01	enet	14	0.02	4.4e-02	0.52	5.6	2.6e-08	0.09	0.00	0.26	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	EXOSC9	0.05	0.02	lasso	7	0.02	5.3e-04	4.81	5.5	3.0e-08	-0.03	0.18	0.70	FALSE
15	GTEx	Nerve Tibial	NUDT6	0.11	0.08	lasso	3	0.05	2.1e-04	5.51	5.5	3.6e-08	0.69	0.78	0.03	FALSE
30	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUDT6	0.10	0.07	lasso	6	0.07	1.0e-07	5.71	5.5	3.8e-08	0.71	0.94	0.06	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	NUDT6	0.04	0.04	enet	9	0.03	2.0e-04	5.78	5.4	6.4e-08	0.64	0.59	0.19	FALSE
16	GTEx	Skin Not Sun Exposed Suprapubic	NUDT6	0.07	0.02	lasso	6	0.03	1.5e-02	4.43	5.4	7.4e-08	0.71	0.19	0.61	FALSE
9	GTEx	Breast Mammary Tissue (Female)	NUDT6	0.30	-0.01	enet	30	0.00	2.6e-01	5.81	5.4	8.3e-08	0.62	0.03	0.33	FALSE
5	GTEx	Brain Cerebellar Hemisphere	BBS7	0.27	0.05	lasso	3	0.08	4.7e-03	-5.43	-5.3	1.1e-07	-0.01	0.08	0.32	FALSE