[Hub]/) : Traits : Leg fat-free mass (right) :

chr4:122,028,784-124,538,705

Best TWAS P=9.24e-19 · Best GWAS P=2.41e-13 conditioned to 0.13

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex BBS7 0.19 0.21 bslmm 423 0.23 1.8e-27 -7.06 -7.5 9.2e-14 -0.01 0.00 1.00 FALSE
2 CommonMind Brain Pre-frontal Cortex NUDT6 0.04 0.04 lasso 3 0.02 6.5e-04 5.87 5.9 4.8e-09 0.74 0.70 0.05 FALSE
3 GTEx Artery Tibial FGF2 0.18 0.05 lasso 3 0.02 1.3e-02 5.22 5.4 7.6e-08 0.36 0.08 0.11 TRUE
4 GTEx Artery Tibial NUDT6 0.08 0.08 lasso 5 0.05 5.6e-05 5.71 5.7 1.2e-08 0.73 0.64 0.10 FALSE
5 GTEx Brain Cerebellar Hemisphere BBS7 0.27 0.05 lasso 3 0.08 4.7e-03 -5.43 -5.3 1.1e-07 -0.01 0.08 0.32 FALSE
6 GTEx Brain Cerebellum BBS7 0.20 -0.01 enet 24 0.01 2.2e-01 -5.37 -5.7 1.2e-08 -0.03 0.07 0.72 FALSE
7 GTEx Breast Mammary Tissue NUDT6 0.25 0.10 lasso 3 0.08 4.2e-05 5.72 5.8 9.1e-09 0.83 0.08 0.88 FALSE
8 GTEx Breast Mammary Tissue (Male) NUDT6 0.29 0.00 lasso 6 0.00 3.5e-01 5.76 5.7 1.0e-08 0.74 0.04 0.43 FALSE
9 GTEx Breast Mammary Tissue (Female) NUDT6 0.30 -0.01 enet 30 0.00 2.6e-01 5.81 5.4 8.3e-08 0.62 0.03 0.33 FALSE
10 GTEx Cells EBV-transformed lymphocytes EXOSC9 0.29 0.17 lasso 7 0.16 6.6e-06 6.38 7.0 2.3e-12 0.01 0.18 0.80 FALSE
11 GTEx Cells Transformed fibroblasts BBS7 0.16 0.09 lasso 7 0.16 2.9e-12 -7.16 -7.5 4.3e-14 -0.03 0.00 1.00 FALSE
12 GTEx Colon Transverse BBS12 0.12 0.05 enet 29 0.12 3.2e-06 0.49 5.4 6.2e-08 0.48 0.04 0.59 TRUE
13 GTEx Muscle Skeletal NUDT6 0.15 0.12 lasso 3 0.11 1.1e-10 5.87 5.9 3.2e-09 0.74 0.96 0.04 TRUE
14 GTEx Muscle Skeletal RP11-170N16.3 0.07 0.07 lasso 3 0.06 8.8e-07 5.28 5.9 3.2e-09 0.74 0.24 0.75 FALSE
15 GTEx Nerve Tibial NUDT6 0.11 0.08 lasso 3 0.05 2.1e-04 5.51 5.5 3.6e-08 0.69 0.78 0.03 FALSE
16 GTEx Skin Not Sun Exposed Suprapubic NUDT6 0.07 0.02 lasso 6 0.03 1.5e-02 4.43 5.4 7.4e-08 0.71 0.19 0.61 FALSE
17 GTEx Skin Sun Exposed Lower leg NUDT6 0.11 0.08 lasso 3 0.08 6.2e-07 5.76 5.8 7.4e-09 0.70 0.93 0.04 FALSE
18 GTEx Testis EXOSC9 0.17 0.07 lasso 8 0.10 2.5e-05 -5.43 7.2 8.3e-13 0.04 0.02 0.98 FALSE
19 ROSMAP Brain Pre-frontal Cortex EXOSC9 0.05 0.02 lasso 7 0.02 5.3e-04 4.81 5.5 3.0e-08 -0.03 0.18 0.70 FALSE
20 ROSMAP Brain Pre-frontal Cortex NUDT6 0.04 0.04 enet 9 0.03 2.0e-04 5.78 5.4 6.4e-08 0.64 0.59 0.19 FALSE
21 YFS Blood EXOSC9 0.06 0.09 bslmm 401 0.09 7.0e-28 6.37 6.9 5.7e-12 0.00 0.27 0.73 FALSE
22 The Cancer Genome Atlas Breast Invasive Carcinoma EXOSC9 0.03 0.04 enet 9 0.04 2.8e-08 6.81 7.5 8.2e-14 0.02 0.06 0.94 FALSE
23 The Cancer Genome Atlas Breast Invasive Carcinoma NUDT6 0.02 0.02 lasso 4 0.01 5.4e-03 5.71 5.7 1.3e-08 0.72 0.13 0.15 FALSE
24 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma CCNA2 0.11 -0.01 enet 14 0.02 4.4e-02 0.52 5.6 2.6e-08 0.09 0.00 0.26 FALSE
25 The Cancer Genome Atlas Colon Adenocarcinoma BBS7 0.05 0.00 blup 47 0.02 1.9e-02 6.86 -7.0 2.0e-12 -0.03 0.02 0.26 FALSE
26 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma CCNA2 0.03 0.01 blup 34 0.02 1.5e-03 -7.03 8.8 9.2e-19 0.02 0.00 0.97 TRUE
27 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma BBS7 0.04 0.04 lasso 2 0.03 6.1e-04 -7.06 -7.1 1.5e-12 -0.03 0.00 0.99 FALSE
28 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma FGF2 0.06 0.04 blup 65 0.05 4.4e-06 6.21 5.9 4.1e-09 0.85 0.01 0.98 FALSE
29 The Cancer Genome Atlas Lung Squamous Cell Carcinoma EXOSC9 0.03 0.02 lasso 2 0.02 1.0e-03 6.34 6.8 8.2e-12 0.01 0.06 0.50 FALSE
30 The Cancer Genome Atlas Prostate Adenocarcinoma NUDT6 0.10 0.07 lasso 6 0.07 1.0e-07 5.71 5.5 3.8e-08 0.71 0.94 0.06 FALSE
31 The Cancer Genome Atlas Thyroid Carcinoma EXOSC9 0.04 0.05 lasso 2 0.04 7.1e-05 6.81 7.6 2.9e-14 0.03 0.02 0.96 FALSE