Best TWAS P=6.12e-52 · Best GWAS P=7.06e-48 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CDK6 | 0.12 | 0.10 | lasso | 2 | 0.10 | 1.9e-12 | 14.103 | 14.1 | 3.3e-45 | 0.89 | 0.11 | 0.89 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | KRIT1 | 0.04 | 0.01 | blup | 318 | 0.02 | 1.2e-03 | 3.631 | -5.1 | 2.7e-07 | -0.20 | 0.60 | 0.01 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | GATAD1 | 0.21 | 0.14 | enet | 10 | 0.16 | 3.4e-13 | 7.172 | -5.1 | 3.0e-07 | -0.44 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Adipose Visceral Omentum | GATAD1 | 0.12 | 0.08 | lasso | 5 | 0.06 | 7.5e-04 | 7.172 | -7.0 | 2.5e-12 | -0.51 | 0.80 | 0.08 | FALSE |
| 5 | GTEx | Adrenal Gland | GATAD1 | 0.40 | 0.22 | lasso | 7 | 0.25 | 2.0e-09 | 7.172 | -8.0 | 1.4e-15 | -0.57 | 0.59 | 0.18 | FALSE |
| 6 | GTEx | Artery Aorta | KRIT1 | 0.15 | 0.00 | enet | 24 | 0.03 | 1.3e-02 | 0.097 | -6.7 | 2.0e-11 | -0.27 | 0.12 | 0.05 | FALSE |
| 7 | GTEx | Artery Aorta | GATAD1 | 0.09 | 0.08 | enet | 4 | 0.07 | 7.4e-05 | 7.172 | -7.0 | 2.8e-12 | -0.49 | 0.48 | 0.12 | FALSE |
| 8 | GTEx | Artery Coronary | GATAD1 | 0.12 | 0.15 | lasso | 3 | 0.12 | 8.0e-05 | 7.118 | -7.4 | 1.2e-13 | -0.54 | 0.16 | 0.30 | FALSE |
| 9 | GTEx | Artery Tibial | GATAD1 | 0.14 | 0.04 | enet | 17 | 0.04 | 4.1e-04 | 7.172 | -6.9 | 5.2e-12 | -0.45 | 0.69 | 0.13 | FALSE |
| 10 | GTEx | Artery Tibial | AC007566.10 | 0.13 | 0.04 | lasso | 5 | 0.00 | 3.1e-01 | 4.492 | -5.2 | 1.6e-07 | -0.10 | 0.08 | 0.05 | FALSE |
| 11 | GTEx | Brain Caudate basal ganglia | GATAD1 | 0.21 | 0.09 | lasso | 4 | 0.08 | 2.3e-03 | 5.778 | -8.2 | 1.8e-16 | -0.56 | 0.05 | 0.55 | FALSE |
| 12 | GTEx | Breast Mammary Tissue (Female) | AC007566.10 | 0.04 | -0.01 | lasso | 2 | 0.01 | 2.0e-01 | 0.734 | -6.5 | 1.1e-10 | -0.32 | 0.03 | 0.14 | FALSE |
| 13 | GTEx | Cells Transformed fibroblasts | GATAD1 | 0.23 | 0.20 | lasso | 4 | 0.22 | 1.4e-16 | 7.172 | -9.5 | 1.4e-21 | -0.69 | 0.90 | 0.10 | FALSE |
| 14 | GTEx | Colon Transverse | GATAD1 | 0.13 | 0.00 | enet | 16 | 0.05 | 3.0e-03 | 7.172 | -8.0 | 1.4e-15 | -0.52 | 0.16 | 0.33 | FALSE |
| 15 | GTEx | Esophagus Mucosa | GATAD1 | 0.16 | 0.05 | enet | 16 | 0.08 | 7.3e-06 | 7.172 | -7.4 | 1.3e-13 | -0.46 | 0.65 | 0.24 | FALSE |
| 16 | GTEx | Esophagus Muscularis | GATAD1 | 0.18 | 0.10 | enet | 33 | 0.13 | 1.6e-08 | 7.172 | -5.9 | 4.2e-09 | -0.38 | 0.97 | 0.01 | FALSE |
| 17 | GTEx | Esophagus Muscularis | FAM133B | 0.07 | 0.01 | enet | 2 | 0.01 | 1.2e-01 | -9.951 | -9.9 | 3.3e-23 | -0.55 | 0.09 | 0.20 | FALSE |
| 18 | GTEx | Lung | GATAD1 | 0.15 | 0.12 | lasso | 2 | 0.11 | 1.1e-08 | 7.172 | -7.2 | 8.8e-13 | -0.53 | 0.99 | 0.00 | FALSE |
| 19 | GTEx | Muscle Skeletal | PEX1 | 0.06 | 0.03 | lasso | 5 | 0.02 | 2.7e-03 | 6.070 | 6.5 | 7.8e-11 | 0.42 | 0.38 | 0.38 | FALSE |
| 20 | GTEx | Muscle Skeletal | GATAD1 | 0.05 | 0.00 | enet | 13 | 0.01 | 2.4e-02 | 3.284 | -6.8 | 1.0e-11 | -0.44 | 0.45 | 0.08 | FALSE |
| 21 | GTEx | Nerve Tibial | GATAD1 | 0.30 | 0.19 | lasso | 5 | 0.23 | 1.8e-16 | 7.172 | -5.5 | 5.0e-08 | -0.44 | 1.00 | 0.00 | FALSE |
| 22 | GTEx | Pancreas | GATAD1 | 0.12 | 0.13 | lasso | 2 | 0.14 | 2.0e-06 | 7.172 | -6.3 | 2.7e-10 | -0.49 | 0.08 | 0.76 | FALSE |
| 23 | GTEx | Pituitary | KRIT1 | 0.21 | -0.01 | enet | 14 | 0.20 | 1.1e-05 | -0.138 | -5.7 | 9.5e-09 | -0.05 | 0.29 | 0.06 | TRUE |
| 24 | GTEx | Skin Not Sun Exposed Suprapubic | GATAD1 | 0.22 | 0.27 | lasso | 4 | 0.26 | 1.1e-14 | 7.172 | -7.3 | 2.2e-13 | -0.53 | 1.00 | 0.00 | FALSE |
| 25 | GTEx | Skin Sun Exposed Lower leg | PEX1 | 0.18 | 0.06 | enet | 41 | 0.03 | 1.5e-03 | -7.900 | -7.7 | 1.8e-14 | -0.44 | 0.21 | 0.13 | FALSE |
| 26 | GTEx | Skin Sun Exposed Lower leg | GATAD1 | 0.30 | 0.10 | enet | 14 | 0.16 | 7.0e-13 | 7.172 | -7.0 | 3.2e-12 | -0.44 | 1.00 | 0.00 | FALSE |
| 27 | GTEx | Spleen | PEX1 | 0.18 | 0.00 | enet | 38 | 0.05 | 2.4e-02 | 3.265 | -6.7 | 1.6e-11 | -0.38 | 0.08 | 0.14 | FALSE |
| 28 | GTEx | Stomach | GATAD1 | 0.30 | 0.13 | lasso | 5 | 0.15 | 8.6e-08 | 7.172 | -7.1 | 1.6e-12 | -0.52 | 0.97 | 0.00 | FALSE |
| 29 | GTEx | Testis | CDK6 | 0.10 | 0.10 | lasso | 3 | 0.09 | 8.0e-05 | 14.537 | -15.2 | 6.1e-52 | -0.96 | 0.00 | 0.99 | TRUE |
| 30 | GTEx | Thyroid | GATAD1 | 0.18 | 0.06 | lasso | 4 | 0.06 | 3.3e-05 | 7.172 | -6.8 | 8.9e-12 | -0.48 | 0.97 | 0.01 | FALSE |
| 31 | METSIM | Adipose | GATAD1 | 0.10 | 0.05 | lasso | 7 | 0.06 | 9.4e-10 | 3.284 | -5.4 | 7.2e-08 | -0.40 | 1.00 | 0.00 | FALSE |
| 32 | ROSMAP | Brain Pre-frontal Cortex | KRIT1 | 0.04 | 0.03 | bslmm | 311 | 0.01 | 9.0e-03 | 3.260 | 6.6 | 5.0e-11 | 0.51 | 0.73 | 0.06 | FALSE |
| 33 | ROSMAP | Brain Pre-frontal Cortex | GATAD1 | 0.17 | 0.15 | lasso | 4 | 0.16 | 6.0e-20 | 7.200 | -7.2 | 8.2e-13 | -0.51 | 1.00 | 0.00 | FALSE |
| 34 | YFS | Blood | CYP51A1 | 0.03 | 0.06 | blup | 288 | 0.05 | 1.2e-16 | 3.593 | -5.2 | 2.6e-07 | -0.32 | 1.00 | 0.00 | FALSE |
| 35 | YFS | Blood | GATAD1 | 0.01 | 0.01 | blup | 297 | 0.01 | 5.1e-04 | 7.172 | -8.8 | 1.1e-18 | -0.53 | 0.74 | 0.09 | FALSE |
| 36 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GATAD1 | 0.06 | 0.04 | lasso | 6 | 0.04 | 2.2e-09 | 6.979 | -6.7 | 2.9e-11 | -0.40 | 0.18 | 0.82 | FALSE |
| 37 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GATAD1 | 0.04 | 0.04 | lasso | 2 | 0.03 | 2.8e-04 | 6.979 | -6.7 | 1.8e-11 | -0.47 | 0.08 | 0.54 | FALSE |
| 38 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C7orf64 | 0.06 | 0.02 | blup | 36 | 0.02 | 6.0e-02 | 6.170 | 5.6 | 2.2e-08 | 0.42 | 0.04 | 0.06 | FALSE |