Best TWAS P=8.59e-10 · Best GWAS P=4.1e-10 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Cerebellum | ZNF484 | 0.21 | 0.01 | lasso | 9 | 0.01 | 1.7e-01 | -6.1 | -5.3 | 1.5e-07 | -0.04 | 0.04 | 0.63 | FALSE |
2 | GTEx | Brain Cerebellum | BICD2 | 0.23 | 0.06 | enet | 21 | 0.17 | 8.5e-06 | -6.1 | -5.4 | 6.0e-08 | -0.01 | 0.02 | 0.75 | FALSE |
3 | GTEx | Esophagus Mucosa | CENPP | 0.09 | 0.01 | lasso | 5 | 0.02 | 2.1e-02 | -4.2 | 5.4 | 8.2e-08 | 0.06 | 0.07 | 0.85 | FALSE |
4 | GTEx | Esophagus Muscularis | BICD2 | 0.09 | 0.02 | enet | 26 | 0.07 | 5.0e-05 | -4.5 | -6.1 | 1.0e-09 | -0.02 | 0.06 | 0.74 | TRUE |
5 | GTEx | Heart Left Ventricle | ECM2 | 0.07 | 0.05 | lasso | 3 | 0.02 | 3.1e-02 | -5.8 | -5.8 | 5.8e-09 | 0.00 | 0.04 | 0.87 | FALSE |
6 | GTEx | Skin Sun Exposed Lower leg | IPPK | 0.17 | 0.07 | enet | 8 | 0.07 | 2.7e-06 | -5.7 | 5.2 | 2.5e-07 | 0.03 | 0.03 | 0.97 | FALSE |
7 | GTEx | Testis | NFIL3 | 0.47 | 0.33 | enet | 8 | 0.29 | 3.8e-13 | -6.2 | 6.1 | 8.6e-10 | -0.99 | 0.00 | 1.00 | TRUE |
8 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | IPPK | 0.06 | 0.03 | blup | 49 | 0.04 | 5.8e-03 | -5.3 | 5.4 | 8.1e-08 | 0.05 | 0.01 | 0.62 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | BICD2 | 0.10 | 0.03 | blup | 52 | 0.03 | 1.3e-02 | -6.1 | -5.5 | 3.7e-08 | -0.03 | 0.01 | 0.76 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | BICD2 | 0.06 | 0.02 | blup | 52 | 0.05 | 2.9e-06 | -5.8 | -5.6 | 2.5e-08 | -0.04 | 0.02 | 0.98 | FALSE |
11 | The Cancer Genome Atlas | Lung Adenocarcinoma | ECM2 | 0.10 | 0.04 | lasso | 2 | 0.04 | 4.2e-05 | -5.2 | -5.3 | 1.1e-07 | -0.03 | 0.00 | 0.98 | FALSE |
12 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | IPPK | 0.03 | 0.02 | blup | 51 | 0.01 | 3.2e-02 | -5.2 | 5.5 | 4.5e-08 | 0.06 | 0.03 | 0.64 | FALSE |
13 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CENPP | 0.19 | 0.09 | blup | 158 | 0.08 | 7.1e-04 | -5.4 | 5.3 | 1.1e-07 | 0.09 | 0.02 | 0.78 | FALSE |