Best TWAS P=2.84e-16 · Best GWAS P=1.44e-19 conditioned to 0.0503
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LOC441454 | 0.05 | 0.01 | lasso | 3 | 0.02 | 1.5e-03 | 5.37 | 5.3 | 1.1e-07 | -0.01 | 0.04 | 0.56 | FALSE |
| 2 | GTEx | Artery Tibial | RP11-435O5.5 | 0.09 | 0.04 | lasso | 2 | 0.02 | 7.3e-03 | 8.35 | -8.2 | 2.8e-16 | -0.44 | 0.06 | 0.77 | TRUE |
| 3 | GTEx | Breast Mammary Tissue | CDC14B | 0.16 | 0.02 | enet | 21 | 0.02 | 3.7e-02 | 6.52 | -5.6 | 1.9e-08 | -0.01 | 0.07 | 0.85 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | AAED1 | 0.17 | 0.02 | lasso | 3 | 0.04 | 2.4e-02 | 6.52 | 5.9 | 3.8e-09 | 0.00 | 0.05 | 0.49 | FALSE |
| 5 | GTEx | Liver | PTCH1 | 0.25 | 0.06 | enet | 11 | 0.03 | 4.9e-02 | 9.00 | 6.1 | 1.1e-09 | 0.91 | 0.01 | 0.93 | FALSE |
| 6 | GTEx | Nerve Tibial | HSD17B3 | 0.14 | 0.00 | enet | 20 | 0.00 | 2.4e-01 | 6.33 | 5.4 | 6.5e-08 | 0.04 | 0.08 | 0.40 | FALSE |
| 7 | GTEx | Nerve Tibial | ZNF367 | 0.10 | 0.05 | lasso | 3 | 0.02 | 7.9e-03 | 6.91 | 6.1 | 1.2e-09 | 0.04 | 0.02 | 0.96 | FALSE |
| 8 | GTEx | Spleen | PTCH1 | 0.33 | 0.08 | lasso | 8 | 0.18 | 1.9e-05 | -0.46 | 5.4 | 6.8e-08 | 0.64 | 0.05 | 0.73 | TRUE |
| 9 | GTEx | Testis | HABP4 | 0.19 | 0.22 | lasso | 9 | 0.21 | 1.1e-09 | 6.63 | 6.6 | 3.5e-11 | 0.02 | 0.07 | 0.93 | FALSE |
| 10 | GTEx | Thyroid | CDC14B | 0.15 | 0.10 | lasso | 5 | 0.08 | 5.3e-07 | 6.32 | -6.5 | 9.0e-11 | -0.03 | 0.20 | 0.79 | FALSE |
| 11 | NTR | Blood | PTCH1 | 0.04 | 0.02 | blup | 433 | 0.02 | 4.1e-08 | 6.55 | 5.9 | 4.8e-09 | 0.64 | 0.02 | 0.98 | TRUE |
| 12 | YFS | Blood | ANP32B | 0.03 | 0.02 | lasso | 9 | 0.02 | 1.9e-08 | -4.96 | 5.6 | 2.8e-08 | -0.03 | 0.00 | 0.99 | TRUE |
| 13 | YFS | Blood | HABP4 | 0.08 | 0.09 | enet | 24 | 0.11 | 5.9e-34 | 6.83 | -6.2 | 5.3e-10 | -0.04 | 0.02 | 0.98 | FALSE |
| 14 | YFS | Blood | PTCH1 | 0.09 | 0.05 | lasso | 8 | 0.05 | 1.2e-15 | 6.53 | 7.1 | 1.7e-12 | 0.95 | 0.03 | 0.97 | FALSE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CDC14B | 0.02 | 0.01 | lasso | 1 | 0.01 | 3.0e-03 | 6.76 | -6.8 | 1.4e-11 | -0.03 | 0.02 | 0.60 | FALSE |
| 16 | The Cancer Genome Atlas | Glioblastoma Multiforme | CDC14B | 0.16 | 0.17 | blup | 41 | 0.19 | 2.6e-06 | 6.52 | -5.9 | 2.7e-09 | 0.00 | 0.04 | 0.93 | FALSE |
| 17 | The Cancer Genome Atlas | Glioblastoma Multiforme | HABP4 | 0.08 | 0.06 | blup | 44 | 0.05 | 1.6e-02 | 6.21 | -6.8 | 7.5e-12 | -0.05 | 0.03 | 0.51 | FALSE |
| 18 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HABP4 | 0.02 | 0.02 | blup | 44 | 0.02 | 7.1e-03 | 6.52 | 6.9 | 6.0e-12 | 0.02 | 0.03 | 0.66 | FALSE |
| 19 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CDC14B | 0.03 | 0.02 | blup | 42 | 0.02 | 2.1e-03 | 6.52 | -6.9 | 5.5e-12 | -0.03 | 0.03 | 0.65 | FALSE |
| 20 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CDC14B | 0.05 | 0.06 | lasso | 5 | 0.06 | 6.5e-07 | 6.49 | -5.8 | 6.9e-09 | -0.01 | 0.07 | 0.93 | FALSE |
| 21 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HABP4 | 0.05 | 0.08 | lasso | 5 | 0.08 | 6.9e-09 | 6.14 | -6.3 | 3.0e-10 | -0.04 | 0.10 | 0.90 | FALSE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PTCH1 | 0.02 | 0.01 | blup | 54 | 0.02 | 1.1e-03 | 7.05 | -7.0 | 2.7e-12 | -0.19 | 0.04 | 0.37 | FALSE |
| 23 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CDC14B | 0.08 | 0.02 | blup | 41 | 0.04 | 1.0e-03 | 5.37 | -7.2 | 7.6e-13 | -0.05 | 0.02 | 0.60 | TRUE |
| 24 | The Cancer Genome Atlas | Thyroid Carcinoma | CDC14B | 0.05 | 0.07 | blup | 42 | 0.08 | 4.8e-08 | 6.58 | -6.6 | 3.4e-11 | -0.02 | 0.04 | 0.96 | FALSE |