[Hub]/) : Traits : Leg predicted mass (right) :

chr5:136,723,696-140,767,031

Best TWAS P=3.14e-14 · Best GWAS P=1.18e-19 conditioned to 2.85e-08

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FAM53C 0.05 0.02 bslmm 291 0.03 4.1e-04 7.4 5.5 4.4e-08 -0.06 0.02 0.94 FALSE
2 GTEx Cells EBV-transformed lymphocytes DNAJC18 0.26 0.09 lasso 2 0.12 9.7e-05 3.4 5.2 2.0e-07 0.49 0.18 0.30 FALSE
3 GTEx Colon Transverse TMCO6 0.15 0.06 enet 16 0.05 1.4e-03 4.7 -5.5 4.7e-08 -0.07 0.09 0.69 FALSE
4 GTEx Esophagus Gastroesophageal Junction DNAJC18 0.17 0.01 lasso 10 0.04 2.0e-02 3.3 6.9 4.5e-12 0.77 0.03 0.85 FALSE
5 GTEx Esophagus Mucosa TMEM173 0.10 0.03 enet 20 0.10 1.8e-07 9.1 -6.3 2.9e-10 -0.60 0.01 0.97 FALSE
6 GTEx Esophagus Muscularis DNAJC18 0.22 0.10 lasso 6 0.13 3.2e-08 3.4 5.2 2.3e-07 0.40 0.56 0.10 FALSE
7 GTEx Nerve Tibial HARS 0.07 0.01 enet 16 0.04 1.1e-03 -4.5 5.5 3.1e-08 -0.03 0.06 0.89 TRUE
8 GTEx Skin Sun Exposed Lower leg WDR55 0.04 0.01 enet 10 0.01 2.8e-02 -4.8 -5.5 3.1e-08 -0.02 0.03 0.92 FALSE
9 GTEx Vagina PURA 0.52 0.05 enet 51 0.09 3.6e-03 5.7 -6.6 4.8e-11 -0.44 0.06 0.10 FALSE
10 ROSMAP Brain Pre-frontal Cortex WNT8A 0.05 0.01 blup 300 0.03 1.0e-04 -1.8 -6.7 2.7e-11 0.05 0.08 0.88 TRUE
11 ROSMAP Brain Pre-frontal Cortex FAM53C 0.13 0.06 lasso 4 0.05 4.6e-07 6.1 6.0 1.5e-09 0.05 0.99 0.00 FALSE
12 ROSMAP Brain Pre-frontal Cortex KDM3B 0.07 0.01 blup 307 0.03 1.0e-04 6.1 -6.2 4.0e-10 -0.03 0.08 0.88 TRUE
13 YFS Blood CXXC5 0.01 0.00 bslmm 244 0.01 2.6e-03 9.1 -6.5 6.0e-11 -0.67 0.00 0.95 FALSE
14 YFS Blood TMCO6 0.01 0.00 blup 329 0.01 4.1e-03 -4.4 -5.2 1.7e-07 -0.03 0.06 0.91 FALSE
15 The Cancer Genome Atlas Breast Invasive Carcinoma KIF20A 0.01 0.00 blup 27 0.01 1.4e-02 -2.6 5.4 7.4e-08 -0.01 0.01 0.39 FALSE
16 The Cancer Genome Atlas Breast Invasive Carcinoma TMEM173 0.02 0.03 blup 7 0.03 4.6e-07 4.6 -5.3 1.1e-07 -0.40 0.07 0.93 FALSE
17 The Cancer Genome Atlas Breast Invasive Carcinoma WDR55 0.10 0.03 enet 8 0.04 3.3e-09 -4.8 -5.3 9.2e-08 0.01 0.02 0.97 FALSE
18 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma UBE2D2 0.05 0.02 enet 6 0.03 4.4e-04 5.0 7.6 3.1e-14 0.76 0.01 0.97 TRUE
19 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma BRD8 0.12 0.07 lasso 4 0.05 1.2e-03 6.8 -6.6 3.4e-11 0.03 0.00 0.98 FALSE