Best TWAS P=1.07e-12 · Best GWAS P=1.67e-16 conditioned to 1.47e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Transverse | DHRS7B | 0.10 | 0.09 | lasso | 3 | 0.07 | 2.3e-04 | -5.9 | -6.0 | 1.6e-09 | -0.15 | 0.23 | 0.46 | FALSE |
| 2 | GTEx | Esophagus Mucosa | TMEM11 | 0.20 | 0.00 | lasso | 7 | 0.01 | 9.3e-02 | 5.2 | 6.1 | 8.6e-10 | 0.10 | 0.08 | 0.12 | TRUE |
| 3 | GTEx | Esophagus Muscularis | DHRS7B | 0.12 | 0.10 | lasso | 3 | 0.09 | 6.8e-06 | -5.5 | -5.4 | 7.7e-08 | -0.06 | 0.83 | 0.02 | FALSE |
| 4 | GTEx | Lung | C17orf103 | 0.08 | 0.01 | enet | 11 | 0.04 | 6.6e-04 | 5.1 | 5.6 | 2.0e-08 | 0.43 | 0.16 | 0.48 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | C17orf103 | 0.11 | 0.02 | enet | 15 | 0.07 | 1.0e-06 | 2.4 | 5.8 | 5.5e-09 | 0.30 | 0.38 | 0.08 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | TMEM11 | 0.08 | 0.08 | lasso | 3 | 0.06 | 9.1e-06 | 5.2 | 5.2 | 2.1e-07 | 0.06 | 0.85 | 0.02 | FALSE |
| 7 | GTEx | Thyroid | DHRS7B | 0.17 | 0.02 | enet | 22 | 0.11 | 1.2e-08 | -5.9 | -6.7 | 1.9e-11 | -0.17 | 0.84 | 0.02 | FALSE |
| 8 | GTEx | Thyroid | KCNJ12 | 0.36 | 0.23 | lasso | 5 | 0.25 | 2.9e-19 | -6.1 | -7.1 | 1.1e-12 | -0.48 | 1.00 | 0.00 | TRUE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | DHRS7B | 0.02 | 0.02 | lasso | 3 | 0.02 | 1.3e-03 | 4.2 | -5.8 | 6.4e-09 | -0.07 | 0.01 | 0.82 | FALSE |
| 10 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | TMEM11 | 0.11 | 0.13 | lasso | 2 | 0.12 | 2.5e-05 | -6.0 | 5.8 | 5.1e-09 | 0.06 | 0.00 | 0.97 | FALSE |