TWAS hub - TMEM11

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.202	0.065	3.2e-04	0.004	NA	0.005	NA	0.008	1.7e-01	NA	1.5e-01	NA	9.3e-02
2	GTEx	Skin Not Sun Exposed Suprapubic	0.191	0.054	2.7e-05	0.179	NA	0.183	NA	0.160	4.2e-10	NA	2.7e-10	NA	4.0e-09
3	GTEx	Skin Sun Exposed Lower leg	0.083	0.031	1.6e-03	0.078	NA	0.033	NA	0.061	5.1e-07	NA	9.4e-04	NA	9.1e-06
4	TCGA	Pheochromocytoma and Paraganglioma	0.107	0.050	1.3e-03	0.133	0.07	0.096	NA	0.116	6.0e-06	0.00098	1.2e-04	NA	2.5e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Overall health rating	8.8	18.9	25.7	4.9	2.8	4.3	5.1
Exposure to tobacco smoke outside home	8.0	10.7	18.7	3.5	2.3	2.6	4.3
Leg fat percentage (left)	7.6	27.6	37.6	6.1	3.4	5.2	5.8
Leg fat percentage (right)	6.2	22.6	32.7	5.7	2.7	4.7	5.3
Body fat percentage	4.4	17.4	25.0	5.0	2.4	3.9	4.9
Leg fat mass (left)	4.4	17.0	24.6	5.0	2.9	3.9	4.4
Body mass index (BMI)	4.1	17.4	29.1	5.4	2.5	4.0	4.3
Medication: Lansoprazole	3.9	4.5	6.6	2.5	1.5	1.7	2.6
Leg fat mass (right)	3.8	14.6	21.9	4.7	2.5	3.6	4.1
Osteoporosis (self-reported)	3.7	4.6	5.7	2.2	2.1	2.4	1.8
Waist circumference	3.4	12.5	18.5	4.3	2.5	3.4	3.7
Trunk fat percentage	3.2	12.8	18.6	4.2	2.1	3.3	4.3
Ever had bowel cancer screening	3.2	3.8	5.4	1.9	1.6	1.9	2.3
Tinnitus: Yes, but not now, but have in the past	3.1	3.3	6.0	1.4	1.4	1.9	2.5
Arm fat percentage (left)	3.1	12.2	19.3	4.4	1.8	3.3	3.9
Type 2 Diabetes (T2D) (2012)	2.9	3.3	5.0	1.9	2.2	2.0	0.8
HDL Cholesterol	2.8	4.6	6.3	-2.5	-2.5	-2.3	-0.8
High blood pressure (siblings)	2.8	4.0	8.8	-1.4	-1.6	-1.6	-3.0
Townsend deprivation index at recruitment	2.7	3.8	6.0	2.0	0.9	2.1	2.5
Age when periods started (menarche)	2.7	6.5	10.4	-3.2	-2.3	-2.8	-1.6
Arm fat percentage (right)	2.7	10.8	17.2	4.1	1.7	3.1	3.7
Whole body fat mass	2.7	11.2	16.2	4.0	2.2	3.0	3.8
Ever depressed for a whole week	2.7	3.3	4.0	-1.9	-2.0	-2.0	-1.3
Ovarian Cancer	2.5	3.3	5.5	2.3	1.4	1.9	1.4
Medication: Omeprazole (e.g. Zanprol)	2.5	3.1	4.4	2.1	1.0	1.9	1.8
BMI	2.3	13.2	22.1	4.7	2.1	3.4	3.8
Arm fat mass (right)	2.3	9.3	14.7	3.8	2.0	2.8	3.3
Trunk fat mass	2.1	9.0	13.0	3.5	1.9	2.6	3.6
Financial difficulties in last 2 years	2.1	2.9	3.6	-1.9	-1.8	-1.1	-1.9
Hip circumference	2.1	8.9	12.8	3.6	2.3	2.5	3.3
Medication: Omeprazole	2.1	2.5	3.7	1.8	0.8	1.7	1.9
Exposure to tobacco smoke at home	2.0	2.3	4.4	2.1	1.1	1.4	1.3
Arm fat mass (left)	2.0	8.4	13.7	3.7	1.8	2.6	3.1
Age at First Birth	1.9	2.8	4.6	-2.1	-0.5	-1.6	-2.0
Sitting height	1.9	13.7	17.7	-4.2	-2.1	-4.0	-4.1
Standing height	1.9	18.6	31.4	-5.6	-1.3	-4.6	-4.5
Mother’s age at death	1.9	2.4	4.9	-1.0	-1.3	-1.4	-2.2
Eye problems/disorders: Glaucoma	1.9	2.2	4.8	-1.5	-2.2	-1.3	-0.6
Pain type(s) experienced in last month: Hip pain	1.9	2.4	5.1	1.5	0.4	1.4	2.3
Leg pain on walking	1.8	2.2	2.5	1.5	1.6	1.4	1.5
Loneliness, isolation	1.8	2.5	5.3	-1.2	-2.3	-1.6	-0.8
Hearing aid user	1.8	2.0	4.2	-0.8	-2.0	-1.3	-1.2
Angina	1.7	2.2	2.9	1.6	0.6	1.7	1.7
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	3.3	1.4	1.4	1.1	1.8
Reaction Time	1.6	3.0	4.2	-2.1	-1.2	-1.5	-1.9
Stomach or abdominal pain in last month	1.6	2.0	3.4	1.8	1.1	1.8	0.7
Prospective memory result	1.6	1.9	4.1	1.4	1.0	0.8	2.0
Glaucoma (self-reported)	1.6	1.9	4.0	-1.5	-2.0	-1.1	-0.2
Number of self-reported non-cancer illnesses	1.6	2.8	6.0	2.5	1.2	2.0	0.5
Myopia	1.6	2.4	4.7	-2.2	-1.0	-1.2	-1.5
Ulcerative Colitis (UC)	1.5	2.8	6.1	1.5	2.5	1.3	1.2
Average weekly fortified wine intake	1.5	1.8	3.9	-1.2	-0.9	-1.0	-2.0
Smoking status: Previous	1.5	2.3	3.3	1.3	1.8	1.5	1.4
Neuroticism (2016)	1.4	2.1	2.8	1.7	1.2	1.6	1.2
Height	1.4	26.3	43.8	-6.6	-2.4	-5.8	-4.7
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	3.6	-1.5	-0.2	-1.9	-1.7
Suffer from ‘nerves’	1.4	2.2	5.3	1.0	1.2	1.0	2.3
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.6	2.0	1.2	1.3	1.2	1.4
Rheumatoid Arthritis	1.3	1.7	4.7	1.2	0.6	0.6	2.2
Lung FVC	1.3	6.5	9.7	2.9	2.5	3.1	1.3
Ever used hormone-replacement therapy (HRT)	1.3	1.7	2.2	1.5	1.2	1.4	1.1
Supplements: Zinc	1.3	1.4	2.0	-1.3	-1.4	-1.3	-0.3
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	2.2	-1.5	-1.2	-1.0	-1.2
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	2.3	-1.2	-1.3	-1.5	-1.0
Chest pain or discomfort	1.3	1.8	6.0	0.7	0.2	0.9	2.5
Medication: Gliclazide	1.3	1.4	2.0	-0.9	-1.4	-1.4	-0.9
Risk taking	1.3	1.9	3.7	-1.9	-1.1	-1.4	-0.7
Cholesterol lowering medication	1.3	1.9	4.2	2.1	0.0	1.6	0.9
Bipolar Disorder (2018)	1.2	1.9	3.8	1.3	2.0	1.3	0.5
Alzheimer’s Disease (in mother)	1.2	1.4	3.0	0.7	1.0	1.0	1.7
Allergy or Eczema	1.2	3.1	3.4	-1.8	-1.6	-1.8	-1.8
Hypothyroidism (self reported)	1.2	2.7	3.5	1.8	1.2	1.9	1.7
Vitamin and mineral supplements	1.2	1.7	3.5	1.9	0.7	1.6	0.4
Illnesses of siblings	1.2	1.7	2.8	0.9	1.7	1.0	1.4
Father’s age at death	1.2	1.6	2.5	-1.5	-1.2	-1.6	-0.6
Number of full sisters	1.2	1.4	2.2	0.8	0.8	1.5	1.5
Long-standing illness, disability or infirmity	1.2	1.8	4.4	2.1	0.3	1.3	0.9
Schizophrenia vs Biploar Disorder	1.1	1.4	2.7	1.6	0.0	1.4	1.0
Prostate Cancer	1.1	1.5	3.0	1.7	1.0	1.4	0.6
Lupus	1.1	1.7	3.9	-2.0	-0.8	-1.5	-0.3
Triglycerides	1.1	1.9	3.4	1.8	1.2	1.4	0.8
Severe depression (siblings)	1.1	1.3	3.1	0.9	1.8	1.0	0.3
High blood pressure (mother)	1.1	1.5	2.0	-1.0	-1.4	-1.3	-1.2
Lung cancer (father)	1.1	1.3	2.2	-1.5	-1.3	-0.9	-0.5
Medication: Blood pressure	1.1	2.0	3.7	1.2	0.5	1.5	1.9
Angina (self-reported)	1.1	1.4	2.0	1.2	0.3	1.4	1.4
Unable to work because of sickness or disability	1.1	1.5	3.3	1.3	0.5	0.9	1.8
Irritable Bowel Disease (IBD)	1.0	2.4	3.4	1.6	1.8	1.3	1.5
Type 2 Diabetes (T2D) (2018)	1.0	1.8	3.6	-0.9	-1.9	-1.6	-0.6
Medication: Atenolol	1.0	1.2	2.3	1.3	-0.2	0.9	1.5
Hair/balding pattern: Pattern 3	1.0	1.5	2.7	-0.5	-1.0	-1.6	-1.4
Peak expiratory flow (PEF)	1.0	2.2	3.9	-1.8	-0.8	-2.0	-1.0
Blood clot in the leg (DVT)	1.0	1.3	1.9	1.4	0.6	1.1	1.3
Neck or shoulder pain in last month	1.0	1.4	3.7	1.0	0.2	0.9	1.9
Mean time to correctly identify matches	1.0	1.8	2.3	-1.5	-1.1	-1.2	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	1.8	-1.3	-0.4	-1.0	-1.4
Comparative height size at age 10	1.0	5.4	7.8	-2.8	-0.5	-2.4	-2.8
Medication: Aspirin	1.0	1.3	1.8	-0.9	-1.4	-1.3	-0.9
Medication: Aspirin	1.0	1.3	1.9	-1.1	-1.4	-1.1	-1.1
Verbal and Numeric Reasoning (VNR)	0.9	2.1	2.9	-1.6	-0.6	-1.6	-1.7
Blood Red Count	0.9	8.7	13.8	-3.4	-2.5	-3.7	-1.9
Blood White Count	0.9	6.9	9.7	-1.9	-2.8	-2.5	-3.1
Smoking Status	0.9	2.1	4.0	1.2	2.0	1.4	1.0
Average weekly spirits intake	0.9	1.1	2.6	1.0	0.6	0.7	1.6
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.6	-0.4	-1.6	-0.9	-1.0
Ever had hysterectomy (womb removed)	0.9	1.1	2.2	1.5	0.7	1.0	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	4.1	-0.8	-1.7	-0.8	-2.0
Hayfever, allergic rhinitis or eczema	0.9	1.9	4.0	-1.0	-1.0	-1.3	-2.0
Diabetes (self-reported)	0.9	1.4	2.8	-0.8	-1.7	-1.5	0.3
Weight	0.9	4.3	6.9	2.6	1.8	1.8	2.0
Impedance of arm (left)	0.9	4.3	8.0	-2.8	-1.8	-2.0	-1.3
Migraine (self-reported)	0.9	1.1	3.2	-0.7	-0.6	-0.4	-1.8
Alcohol intake frequency.	0.9	2.1	3.7	1.6	0.9	1.2	1.9
Knee pain experienced in last month	0.9	1.5	3.3	1.4	0.7	0.4	1.8
Ever taken oral contraceptive pill	0.9	1.0	2.3	0.7	1.5	1.1	-0.1
Bipolar Disorder or Schizophrenia	0.8	2.0	3.5	1.9	1.8	1.0	-0.1
Schizophrenia (2014)	0.8	1.8	3.5	1.9	1.7	0.8	-0.2
Serious illness, injury or assault to yourself	0.8	1.0	1.7	1.3	0.4	0.9	1.1
Hair/balding pattern: Pattern 2	0.8	1.0	2.2	-1.2	0.0	-0.7	-1.5
Medication: Ramipril	0.8	1.1	2.0	1.4	0.6	0.6	1.3
Impedance of arm (right)	0.8	3.9	7.7	-2.8	-1.6	-2.0	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	1.7	1.3	0.7	1.2	0.6
Medication for cholesterol	0.8	1.2	3.1	-1.8	-0.7	-1.2	-0.3
Osteoarthritis (self-reported)	0.8	1.1	1.5	1.0	1.1	1.2	0.8
Average weekly champagne plus white wine intake	0.8	1.1	2.3	1.1	1.5	1.0	0.2
Medication: Blood pressure	0.8	1.4	2.9	1.7	1.0	1.3	-0.3
Basal cell carcinoma (self-reported)	0.8	0.9	2.3	-0.7	-0.4	-0.8	-1.5
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.5	1.2	0.5	1.0	1.1
Hearing difficulty/problems: Yes	0.7	1.0	1.5	-1.0	-1.2	-1.1	-0.8
Taking other prescription medications	0.7	1.1	2.0	1.4	-0.3	1.0	1.1
Multivitamins +/- minerals	0.7	0.8	1.6	-1.2	-0.4	-1.3	0.5
Medication: Levothyroxine sodium	0.7	1.2	2.3	1.0	0.7	1.1	1.5
Heart attack	0.7	0.8	1.7	0.8	0.3	0.9	1.3
Forced expiratory volume in 1-second (FEV1)	0.7	2.2	4.0	-1.6	-0.1	-1.5	-2.0
Pulse rate	0.7	1.1	1.7	1.3	0.9	0.8	1.1
Depression (self-reported)	0.7	0.8	1.3	1.1	0.2	0.9	1.0
Length of working week for main job	0.7	0.8	1.6	0.1	1.3	1.2	-0.1
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	2.1	1.4	0.8	1.4	1.0
Commuting to job workplace: Cycle	0.7	0.9	1.7	-0.8	-0.5	-0.9	-1.3
Major Depression (MDD)	0.6	0.7	1.0	0.9	1.0	0.7	0.8
Primary Biliary Cirrhosis	0.6	0.8	1.4	1.2	0.5	0.7	1.1
Ulcerative Colitis	0.6	0.9	1.8	0.6	1.3	0.7	0.9
Relative age of first facial hair	0.6	1.3	4.0	2.0	0.7	0.9	0.2
Medication: Metformin	0.6	0.8	2.2	-0.3	-1.5	-1.0	-0.1
Had other major operations	0.6	0.7	1.9	-0.6	-1.4	-0.6	0.1
Medication: Simvastatin	0.6	0.9	1.6	1.3	-0.3	1.0	0.9
Time employed in main current job	0.6	0.7	1.9	0.4	-1.4	-0.8	0.3
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.1	-1.2	0.5	-1.2	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	4.2	-1.2	-0.3	-1.2	-2.1
Tense / ‘highly strung’	0.6	1.0	1.4	-1.1	-1.2	-0.8	-0.8
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.2	-0.9	-0.0	-1.1	-1.5
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.4	1.2	0.6	1.1	0.2
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.1	0.3	1.1	0.9	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	1.8	-1.2	0.1	-1.4	-1.2
Average weekly red wine intake	0.6	0.9	1.4	-1.1	-0.7	-0.7	-1.2
Qualifications: nursing, teaching	0.6	0.9	2.1	0.1	1.2	0.0	-1.5
Guilty feelings	0.6	1.0	1.8	-1.4	-0.9	-1.1	-0.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.2	0.5	0.9	0.8	1.1
Illnesses of father: High blood pressure	0.6	0.8	1.7	0.8	1.3	0.9	0.3
Age started oral contraceptive pill	0.6	0.8	1.6	0.8	0.8	0.5	1.3
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.6	0.9	0.4	0.9	1.3
Pack years of smoking	0.6	0.8	2.3	0.8	0.3	0.7	1.5
Crohns Disease (2017)	0.5	1.2	2.4	1.2	0.5	0.9	1.5
Body Mass Index (BMI) (2010)	0.5	0.6	2.1	1.4	-0.4	0.3	0.5
Hand grip strength (left)	0.5	1.4	3.9	-1.0	0.6	-0.6	-2.0
Sensitivity / hurt feelings	0.5	0.9	2.8	0.6	-0.2	0.5	1.7
Pack years adult smoking proportion	0.5	0.8	1.9	0.8	0.3	0.7	1.4
Nervous feelings	0.5	0.9	2.4	0.7	-0.3	0.8	1.6
Hearing difficulty/problems with background noise	0.5	0.9	1.5	1.2	0.2	0.7	1.2
Fluid intelligence score	0.5	1.0	2.1	-1.1	-0.5	-0.8	-1.4
Alcohol intake versus 10 years previously	0.5	0.8	1.5	1.2	0.4	0.4	1.2
Mouth/teeth dental problems: Dentures	0.5	0.9	2.7	0.5	0.3	0.7	1.6
Breastfed as a baby	0.5	0.6	0.9	-0.6	-0.8	-0.9	-0.7
Pulse wave reflection index	0.5	0.6	1.3	-0.5	0.9	-0.3	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.1	1.1	0.4	0.9	0.8
Number of children fathered	0.5	0.6	1.2	0.1	0.8	0.7	-1.1
Age at first live birth	0.5	1.0	1.6	-1.3	-0.7	-0.4	-1.3
Friendships satisfaction	0.5	0.6	1.4	0.7	-0.6	0.1	1.2
Impedance of whole body	0.5	2.5	5.8	-2.4	-1.4	-1.4	-0.6
Schizophrenia (2018)	0.4	0.7	1.9	1.4	0.8	0.3	-0.5
Fasting Glucose	0.4	0.4	1.0	-0.7	-0.4	0.1	-1.0
Cardiovascular Disease	0.4	1.2	2.6	0.3	-1.3	-0.7	-1.6
Medication: Co-codamol	0.4	0.5	0.9	1.0	0.6	0.8	0.2
Supplements: Glucosamine	0.4	0.5	0.9	-0.7	-0.8	-1.0	-0.2
Chronic bronchitis/emphysema (father)	0.4	0.4	0.9	0.1	-0.9	-0.2	0.9
Past tobacco smoking	0.4	0.7	1.6	-0.6	-1.3	-0.8	-0.6
Alcohol usually taken with meals	0.4	0.7	1.9	0.3	1.4	0.5	0.7
Had menopause	0.4	0.4	1.3	0.6	0.3	0.2	1.1
Forced vital capacity (FVC)	0.4	1.7	4.6	-1.1	0.5	-0.8	-2.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.8	0.2	-0.9	0.2	-1.7
Allergy	0.4	0.9	2.5	0.5	0.8	0.6	1.6
Worrier / anxious feelings	0.4	0.8	1.8	0.7	0.4	0.9	1.3
Birth weight of first child	0.4	0.7	1.5	1.2	0.6	1.0	-0.2
Medication: Paracetamol	0.4	0.7	1.5	-0.7	-1.2	-0.8	0.2
Forced vital capacity (FVC), Best measure	0.4	1.4	4.5	-0.8	0.3	-0.6	-2.1
Medication: Allopurinol	0.4	0.5	0.7	0.8	0.0	0.9	-0.8
Had major operations	0.4	0.4	1.3	-0.4	-1.1	-0.5	-0.2
Illnesses of father: Heart disease	0.4	0.6	1.3	-0.6	-0.6	-0.6	-1.2
Diabetes diagnosed by doctor	0.4	0.6	1.5	-0.1	-1.2	-0.9	0.5
Eye problems/disorders: Cataract	0.4	0.5	1.1	0.9	-0.1	0.4	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.7	0.4	-1.3	-0.4	0.0
Commuting to job workplace: Public transport	0.4	0.5	0.6	-0.8	-0.6	-0.8	-0.5
Average weekly beer plus cider intake	0.4	0.6	2.1	0.4	0.1	0.3	1.4
Worry (Nagel 2018)	0.3	0.7	1.0	0.9	0.1	1.0	0.9
Alzheimer’s Disease (in father)	0.3	0.3	0.6	-0.1	-0.8	-0.5	-0.6
Bipolar Disorder (2011)	0.3	0.3	0.7	0.0	0.0	0.7	0.8
LDL Cholesterol	0.3	0.4	1.0	0.7	-0.5	0.3	1.0
Number of treatments/medications taken	0.3	0.5	1.6	0.5	-1.3	-0.0	0.1
Qualifications: CSEs or equivalent	0.3	0.4	1.3	-0.5	-0.4	-0.2	-1.1
Qualifications: None of the above	0.3	0.7	1.1	1.0	0.0	0.9	1.1
Mouth/teeth dental problems	0.3	0.4	1.3	0.3	0.3	0.2	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	0.9	0.9	0.6	1.0	0.4
Noisy workplace	0.3	0.3	1.0	1.0	-0.1	0.5	0.1
Asthma	0.3	0.7	1.0	-0.9	-0.7	-0.7	-1.0
Medication: Cholesterol lowering	0.3	0.5	1.7	0.1	-0.6	0.2	1.3
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.6	0.3	0.6	0.4	0.8
Gout (self-reported)	0.3	0.4	0.8	0.4	0.1	0.8	-0.9
Birth weight	0.3	0.6	0.9	0.9	0.9	0.4	0.9
Shortness of breath walking on level ground	0.3	0.4	0.7	0.1	-0.8	-0.2	0.9
Medication: Seretide 50 evohaler	0.3	0.4	0.6	-0.7	-0.8	-0.7	-0.3
Hypertension (Self-reported)	0.3	0.7	1.4	1.2	0.6	1.1	0.0
Illnesses of siblings: Diabetes	0.3	0.3	1.0	-0.5	-1.0	-0.3	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.7	-0.8	-0.6	-0.7	-0.7
Miserableness	0.3	0.5	1.0	-1.0	-0.9	-0.3	-0.4
Wears glasses or contact lenses	0.3	0.4	0.8	0.3	0.6	0.9	0.6
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.6	-0.6	-0.5	-0.8	0.4
High cholesterol (Self-reported)	0.3	0.5	1.0	0.5	-1.0	0.2	0.7
Number of operations (self-reported)	0.3	0.4	1.0	-0.4	-1.0	-0.5	-0.5
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.9	-1.2	-0.6	-1.4	-0.2
Pain experienced in last month	0.3	0.6	1.7	-0.2	-0.6	-0.2	-1.3
Depressed Affect (Nagel 2018)	0.2	0.4	0.9	-0.5	-0.9	-0.5	-0.4
Depression (Nagel 2018)	0.2	0.2	0.7	-0.4	-0.3	-0.1	-0.9
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.2	-0.5	-0.2	-0.8	-1.1
Crohns Disease (2012)	0.2	0.3	0.7	0.5	0.0	0.4	0.9
Systolic Blood Pressure	0.2	0.9	3.4	-0.3	-0.5	-0.1	-1.8
Lung FEV1/FVC ratio	0.2	1.2	2.4	-1.3	-0.5	-1.6	0.4
Medication for hormone replacement therapy	0.2	0.2	0.6	0.2	0.8	0.4	-0.1
Diabetes (mother)	0.2	0.3	0.8	0.3	-0.9	-0.6	0.3
Impedance of leg (right)	0.2	1.2	2.5	-1.6	-1.3	-0.8	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.9	-0.5	0.1	0.1	1.0
Relative age voice broke	0.2	0.4	0.9	0.9	0.4	0.5	-0.4
High blood pressure	0.2	0.5	1.1	0.8	0.6	1.0	-0.1
Pain all over the body in last month	0.2	0.2	0.4	-0.7	-0.4	-0.4	0.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.8	0.9	0.4	0.2	0.1
Neuroticism score	0.2	0.4	1.3	-0.4	-1.1	-0.1	0.5
Trunk fat-free mass	0.2	1.0	1.6	-0.8	0.5	-1.2	-1.3
Falls in the last year	0.2	0.3	0.6	0.8	-0.1	0.6	0.5
Number of live births	0.2	0.2	0.5	0.5	0.2	0.7	0.3
Happiness	0.2	0.2	0.8	0.0	-0.9	-0.1	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	0.7	0.4	0.5	0.0
Pulse wave Arterial Stiffness index	0.2	0.3	0.6	-0.3	0.8	0.1	-0.6
Trunk predicted mass	0.2	1.0	1.6	-0.8	0.5	-1.3	-1.2
Loud music exposure frequency	0.2	0.2	0.4	-0.6	-0.6	-0.2	0.2
Number of full brothers	0.2	0.3	0.7	0.4	-0.2	-0.4	0.9
Wheeze or whistling in the chest in last year	0.2	0.3	0.7	0.4	0.2	0.8	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	-0.0	0.6	0.2	-0.6
Pulse wave peak to peak time	0.2	0.3	0.8	-0.1	-0.9	-0.4	0.3
Qualifications: College or University degree	0.2	0.6	1.3	-0.1	1.1	0.1	-1.1
Medication for pain relief, constipation, heartburn	0.2	0.4	0.9	-0.5	0.7	-0.2	-0.9
Age at last live birth	0.2	0.3	1.0	-0.5	-0.2	0.1	-1.0
Family relationship satisfaction	0.2	0.2	0.5	0.2	-0.7	-0.1	0.6
Leg fat-free mass (right)	0.2	0.8	2.8	0.7	1.7	0.1	-0.1
Back pain experienced in last month	0.2	0.2	0.9	-0.2	-0.2	-0.1	1.0
Mineral and other dietary supplements	0.2	0.2	0.6	0.4	0.3	0.4	-0.8
Breast cancer (self-reported)	0.2	0.3	0.7	0.4	-0.3	-0.3	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.6	0.8	0.4	0.6	-0.8
Leg predicted mass (right)	0.2	0.8	2.7	0.7	1.6	0.2	-0.1
Financial situation satisfaction	0.2	0.2	0.5	0.1	-0.7	-0.1	-0.5
Ever smoked	0.2	0.3	0.6	-0.4	0.7	-0.1	-0.6
Irritability	0.2	0.3	0.7	0.8	-0.1	0.2	0.6
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.6	0.3	0.6	0.8	-0.2
Fractured/broken bones in last 5 years	0.2	0.2	0.3	0.6	0.4	0.4	0.5
Alzheimer’s Disease (including proxy)	0.1	0.2	0.6	0.1	-0.2	0.1	0.8
Breast Cancer	0.1	0.3	0.8	0.2	0.4	0.9	0.4
Coronary Artery Disease (CAD)	0.1	0.1	0.3	-0.2	0.3	-0.3	0.5
Mean Putamen Volume	0.1	0.2	0.6	-0.1	0.1	-0.1	-0.8
Heel T-Score	0.1	1.0	2.2	1.1	-0.7	0.5	-1.5
Respiratory disease	0.1	0.2	0.5	0.2	0.5	0.2	-0.7
Neuroticism	0.1	0.3	1.1	-0.2	-1.1	-0.0	0.1
Chronotype (morning person)	0.1	0.3	0.7	0.9	-0.5	-0.0	0.3
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	0.2	0.4	0.5	0.0
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.4	-0.4	-0.4	-0.3
Diabetes (father)	0.1	0.1	0.4	0.0	0.7	-0.2	-0.1
Leg fat-free mass (left)	0.1	0.6	1.8	0.8	1.3	0.1	-0.1
Hand grip strength (right)	0.1	0.4	0.6	-0.8	0.6	-0.4	-0.7
Maternal smoking around birth	0.1	0.2	0.6	0.1	0.5	0.1	0.8
Fed-up feelings	0.1	0.2	0.5	-0.6	-0.7	-0.2	-0.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.4	0.2	-0.7	-0.3	0.1
Impedance of leg (left)	0.1	0.5	1.2	-1.1	-0.5	-0.1	0.8
Leg predicted mass (left)	0.1	0.6	1.7	0.8	1.3	0.1	-0.0
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.4	-0.6	-0.2	-0.2	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.6	-0.1	-0.1	0.5
Hair/balding pattern: Pattern 4	0.1	0.1	0.4	-0.4	-0.2	0.0	0.6
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.5	-0.7	-0.2	-0.2	0.4
Headache pain in last month	0.1	0.1	0.5	-0.2	-0.1	-0.2	0.7
Medication: Amlodipine	0.1	0.1	0.3	-0.2	-0.4	0.2	-0.5
Arm fat-free mass (right)	0.1	0.7	1.6	0.9	1.3	0.2	0.4
Comparative body size at age 10	0.1	0.4	0.7	-0.6	-0.2	-0.8	-0.6
Worry too long after embarrassment	0.1	0.2	0.8	-0.3	-0.2	0.3	0.9
Health satisfaction	0.1	0.2	0.5	0.7	-0.1	0.5	0.1
Eye problems/disorders: None of the above	0.1	0.1	0.5	-0.0	0.7	0.0	-0.2
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	-0.4	-0.1	0.0	0.5
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.1	-0.2	0.5	0.1
Medication: Ibuprofen	0.1	0.1	0.2	-0.5	0.2	0.4	0.1
Heart disease (mother)	0.1	0.2	0.3	0.6	-0.2	0.2	0.5
Arm predicted mass (right)	0.1	0.6	1.4	0.8	1.2	0.1	0.3
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	-0.2	-0.3	0.3	0.2
Supplements: Vitamin C	0.1	0.1	0.3	-0.5	-0.1	-0.5	0.2
Whole body fat-free mass	0.1	0.4	0.9	-0.1	0.9	-0.7	-0.6
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.3	-0.4	-0.3	-0.3	-0.5
Mood swings	0.1	0.2	0.4	-0.3	-0.7	-0.3	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.4	-0.6	0.3	0.2	-0.1
Commuting to job workplace: Walk	0.1	0.1	0.2	0.5	0.0	-0.1	0.3
Asthma (self-reported)	0.1	0.2	0.4	-0.6	-0.3	-0.3	-0.7
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	-0.2	0.5	0.1	-0.3
Whole body water mass	0.1	0.4	1.0	0.0	1.0	-0.6	-0.6
Medication: Paracetamol	0.1	0.2	0.6	-0.2	-0.0	0.1	0.8
Alcohol drinker status: Never	0.1	0.1	0.3	0.3	-0.5	-0.0	0.4
Basal metabolic rate	0.1	0.5	1.6	0.7	1.2	-0.0	0.0
Arm fat-free mass (left)	0.1	0.3	1.0	0.6	1.0	-0.2	0.1
Diastolic blood pressure, automated reading	0.1	0.2	0.8	0.4	0.1	0.0	-0.9
Supplements: Calcium	0.1	0.1	0.3	-0.1	0.3	0.4	0.6
Heart disease (siblings)	0.1	0.2	0.6	0.1	-0.8	-0.2	0.3
Alcohol drinker status: Previous	0.1	0.2	0.6	-0.1	0.1	0.2	-0.8
Arm predicted mass (left)	0.1	0.4	1.1	0.7	1.1	-0.0	0.0
Neuroticism (Nagel 2018)	0.0	0.1	0.3	-0.1	-0.6	-0.0	0.2
HbA1C	0.0	0.0	0.0	-0.0	0.2	0.1	0.0
Blood Eosinophil Count	0.0	0.2	0.5	-0.3	0.5	-0.3	-0.7
Blood Platelet Count	0.0	0.5	1.6	1.3	0.1	0.4	-0.3
Waist Hip Ratio (WHR)	0.0	0.2	0.4	-0.3	0.3	0.6	0.4
Hair Pigment	0.0	0.3	0.7	-0.4	-0.6	-0.8	0.2
Tanning	0.0	0.5	1.0	-0.1	1.0	0.5	1.0
Systolic blood pressure, automated reading	0.0	0.1	0.3	0.6	-0.2	0.1	-0.3
Current tobacco smoking	0.0	0.0	0.1	-0.3	0.1	0.2	-0.2
Number of incorrect matches in round	0.0	0.0	0.1	-0.1	0.0	0.4	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	0.1	-0.1	0.2	0.3
Illnesses of mother	0.0	0.0	0.1	-0.1	-0.2	0.0	0.3
Pulse rate, automated reading	0.0	0.1	0.2	0.4	0.2	-0.1	0.1
Smoking status: Current	0.0	0.0	0.2	-0.1	0.0	0.0	-0.4
Medication: Bendroflumethiazide	0.0	0.0	0.0	-0.0	-0.2	0.1	-0.1
Medication: Lisinopril	0.0	0.0	0.0	0.0	-0.0	0.0	0.1
Medication: Atorvastatin	0.0	0.1	0.2	0.2	0.1	0.4	-0.0

Hub : Genes

TMEM11

Models

Trait associations