[Hub]/) : Traits : Leg fat percentage (left) :

chr20:24,230,055-26,182,690

Best TWAS P=1.87e-12 · Best GWAS P=2.67e-10 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ABHD12 0.10 0.17 blup 405 0.17 1.7e-20 6.0 6.8 1.0e-11 0.77 0.09 0.91 FALSE
2 CommonMind Brain Pre-frontal Cortex NINL 0.19 0.17 lasso 20 0.23 1.2e-27 6.1 6.9 4.8e-12 0.83 0.08 0.92 FALSE
3 GTEx Adipose Visceral Omentum ABHD12 0.06 0.00 lasso 8 0.00 4.6e-01 6.1 6.0 2.3e-09 0.65 0.08 0.69 FALSE
4 GTEx Artery Aorta ABHD12 0.06 0.03 enet 6 0.03 5.4e-03 5.8 5.4 5.5e-08 0.76 0.09 0.86 FALSE
5 GTEx Artery Aorta NINL 0.17 0.18 lasso 6 0.19 1.5e-10 6.1 6.4 1.7e-10 0.80 0.07 0.93 FALSE
6 GTEx Artery Tibial ABHD12 0.12 0.12 enet 25 0.15 7.1e-12 6.0 6.0 2.4e-09 0.78 0.10 0.90 FALSE
7 GTEx Brain Caudate basal ganglia ABHD12 0.09 0.05 enet 13 0.04 2.9e-02 6.1 6.3 3.5e-10 0.80 0.07 0.78 FALSE
8 GTEx Brain Cerebellar Hemisphere PYGB 0.20 0.16 lasso 5 0.12 5.8e-04 5.4 -5.2 2.5e-07 -0.65 0.09 0.74 TRUE
9 GTEx Brain Cerebellar Hemisphere ENTPD6 0.22 0.26 lasso 3 0.17 3.8e-05 5.4 -5.4 5.7e-08 -0.77 0.14 0.85 FALSE
10 GTEx Brain Cortex ABHD12 0.08 0.11 lasso 8 0.09 1.4e-03 6.2 5.8 8.2e-09 0.78 0.07 0.77 FALSE
11 GTEx Breast Mammary Tissue CST7 0.10 0.00 lasso 4 0.00 7.3e-01 -4.9 5.4 8.5e-08 0.65 0.08 0.65 FALSE
12 GTEx Breast Mammary Tissue ABHD12 0.08 0.09 lasso 5 0.09 3.3e-05 6.1 6.0 2.2e-09 0.69 0.08 0.89 FALSE
13 GTEx Breast Mammary Tissue (Male) ABHD12 0.06 0.01 lasso 3 0.02 1.3e-01 4.5 5.4 8.1e-08 0.44 0.05 0.17 FALSE
14 GTEx Cells EBV-transformed lymphocytes PYGB 0.38 0.08 lasso 5 0.06 7.0e-03 5.4 5.2 2.0e-07 0.65 0.11 0.74 FALSE
15 GTEx Cells Transformed fibroblasts ABHD12 0.24 0.33 lasso 4 0.35 6.3e-27 6.2 6.3 3.4e-10 0.81 0.06 0.94 FALSE
16 GTEx Colon Sigmoid ABHD12 0.17 0.17 lasso 15 0.17 1.0e-06 5.9 5.9 3.7e-09 0.76 0.09 0.90 FALSE
17 GTEx Esophagus Gastroesophageal Junction ABHD12 0.15 0.14 lasso 13 0.14 7.0e-06 5.4 5.3 9.2e-08 0.74 0.08 0.92 FALSE
18 GTEx Esophagus Mucosa ENTPD6 0.09 0.04 enet 20 0.06 4.2e-05 6.0 -5.2 2.2e-07 -0.55 0.10 0.89 FALSE
19 GTEx Esophagus Muscularis ABHD12 0.10 0.10 enet 42 0.09 4.5e-06 6.0 5.4 7.8e-08 0.67 0.08 0.92 TRUE
20 GTEx Heart Atrial Appendage ABHD12 0.07 0.06 enet 16 0.06 1.0e-03 6.1 6.0 1.9e-09 0.81 0.08 0.91 FALSE
21 GTEx Heart Left Ventricle ABHD12 0.15 0.14 lasso 10 0.12 4.0e-07 6.2 6.4 1.7e-10 0.82 0.06 0.94 FALSE
22 GTEx Heart Left Ventricle NINL 0.08 0.03 enet 11 0.05 1.1e-03 6.0 5.7 1.3e-08 0.69 0.14 0.78 FALSE
23 GTEx Liver ABHD12 0.20 0.20 lasso 19 0.15 7.3e-05 6.0 6.0 2.7e-09 0.81 0.09 0.90 FALSE
24 GTEx Liver APMAP 0.20 -0.01 lasso 9 0.00 3.8e-01 6.0 5.1 3.1e-07 0.59 0.08 0.61 FALSE
25 GTEx Lung ABHD12 0.06 0.00 lasso 6 0.00 2.7e-01 5.6 6.1 1.2e-09 0.54 0.12 0.66 FALSE
26 GTEx Lung NINL 0.07 0.05 lasso 4 0.04 5.3e-04 -4.0 -5.2 2.2e-07 -0.72 0.09 0.90 FALSE
27 GTEx Nerve Tibial ABHD12 0.24 0.44 lasso 11 0.44 5.1e-34 6.1 -5.8 5.0e-09 -0.81 0.09 0.91 FALSE
28 GTEx Pancreas ENTPD6 0.11 0.05 enet 23 0.05 5.0e-03 5.6 -6.3 3.6e-10 -0.58 0.10 0.84 FALSE
29 GTEx Pituitary ABHD12 0.27 0.31 enet 25 0.31 1.8e-08 6.0 6.5 6.5e-11 0.77 0.09 0.91 FALSE
30 GTEx Skin Sun Exposed Lower leg ABHD12 0.07 0.03 lasso 10 0.05 7.3e-05 4.7 6.0 2.4e-09 0.72 0.11 0.87 FALSE
31 GTEx Spleen PYGB 0.15 0.09 lasso 6 0.04 2.6e-02 6.0 5.7 9.2e-09 0.84 0.09 0.81 FALSE
32 GTEx Testis ABHD12 0.21 0.18 enet 25 0.23 1.1e-10 6.1 6.2 5.6e-10 0.71 0.07 0.93 FALSE
33 GTEx Thyroid ABHD12 0.05 0.04 lasso 5 0.03 3.9e-03 6.0 -6.0 2.1e-09 -0.80 0.09 0.88 FALSE
34 GTEx Thyroid NINL 0.13 0.18 enet 17 0.20 6.2e-15 -4.0 -6.3 2.8e-10 -0.72 0.38 0.62 FALSE
35 ROSMAP Brain Pre-frontal Cortex PYGB 0.20 0.10 bslmm 414 0.11 3.2e-14 5.1 -5.9 3.8e-09 -0.66 0.54 0.46 FALSE
36 ROSMAP Brain Pre-frontal Cortex ABHD12 0.26 0.35 enet 35 0.42 7.9e-58 6.0 6.1 1.4e-09 0.69 0.08 0.92 FALSE
37 ROSMAP Brain Pre-frontal Cortex NINL 0.19 0.19 enet 18 0.25 2.1e-32 6.0 5.7 1.4e-08 0.81 0.07 0.93 FALSE
38 ROSMAP Brain Pre-frontal Cortex ENTPD6 0.32 0.10 bslmm 432 0.12 1.8e-15 5.6 7.0 1.9e-12 0.23 0.52 0.48 TRUE
39 YFS Blood ABHD12 0.15 0.35 bslmm 390 0.34 2.2e-118 6.2 6.4 1.8e-10 0.83 0.06 0.94 TRUE
40 The Cancer Genome Atlas Bladder Urothelial Carcinoma ABHD12 0.04 0.00 blup 77 0.02 6.6e-03 6.1 5.8 6.6e-09 0.85 0.04 0.53 FALSE
41 The Cancer Genome Atlas Breast Invasive Carcinoma PYGB 0.08 0.02 enet 7 0.03 1.7e-07 4.9 -5.2 2.2e-07 -0.51 0.87 0.10 FALSE
42 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma PYGB 0.08 0.04 blup 74 0.06 1.0e-03 6.0 -5.9 4.3e-09 -0.69 0.04 0.86 TRUE
43 The Cancer Genome Atlas Colon Adenocarcinoma NINL 0.20 0.06 lasso 4 0.08 2.7e-05 4.2 5.3 1.1e-07 0.76 0.12 0.77 FALSE
44 The Cancer Genome Atlas Esophageal Carcinoma LOC100134868 0.14 0.11 lasso 2 0.10 4.6e-04 -5.4 -5.3 1.4e-07 -0.51 0.00 0.89 FALSE
45 The Cancer Genome Atlas Glioblastoma Multiforme ABHD12 0.14 0.10 lasso 5 0.13 1.1e-04 5.9 6.0 1.7e-09 0.77 0.06 0.89 FALSE
46 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ABHD12 0.04 0.03 blup 77 0.04 4.0e-05 6.2 6.1 1.3e-09 0.86 0.05 0.95 FALSE
47 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma GINS1 0.03 0.01 enet 13 0.02 4.3e-03 3.0 5.1 2.9e-07 0.87 0.03 0.67 FALSE
48 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ABHD12 0.03 0.01 blup 77 0.01 8.7e-03 3.6 5.7 9.0e-09 0.67 0.06 0.75 FALSE
49 The Cancer Genome Atlas Brain Lower Grade Glioma ABHD12 0.04 0.06 blup 77 0.06 2.2e-07 6.1 6.2 4.3e-10 0.83 0.07 0.93 FALSE
50 The Cancer Genome Atlas Liver Hepatocellular Carcinoma ABHD12 0.07 0.05 blup 77 0.05 2.4e-03 6.0 5.7 1.2e-08 0.77 0.05 0.83 FALSE
51 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma ABHD12 0.08 0.09 blup 80 0.09 1.7e-06 6.1 5.8 8.8e-09 0.82 0.06 0.94 FALSE
52 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma ENTPD6 0.07 0.07 lasso 1 0.04 9.2e-03 5.4 -5.4 6.4e-08 -0.77 0.04 0.53 FALSE
53 The Cancer Genome Atlas Prostate Adenocarcinoma ABHD12 0.03 0.02 lasso 4 0.03 5.8e-04 -5.8 6.0 2.0e-09 0.71 0.06 0.77 FALSE
54 The Cancer Genome Atlas Testicular Germ Cell Tumors NINL 0.11 0.03 blup 81 0.07 2.1e-03 -5.9 -5.7 1.4e-08 -0.69 0.03 0.70 FALSE
55 The Cancer Genome Atlas Thyroid Carcinoma ENTPD6 0.16 0.14 lasso 4 0.13 1.2e-12 5.4 -5.3 1.3e-07 -0.76 0.07 0.93 FALSE
56 The Cancer Genome Atlas Thyroid Carcinoma NINL 0.08 0.14 lasso 11 0.13 2.9e-12 6.1 -5.8 6.4e-09 -0.80 0.02 0.98 FALSE
57 The Cancer Genome Atlas Thyroid Carcinoma PYGB 0.10 0.08 lasso 7 0.07 1.4e-07 4.4 -5.2 2.1e-07 -0.44 0.80 0.19 FALSE