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chr20:24,230,055-26,182,690

Best TWAS P=1.87e-12 · Best GWAS P=2.67e-10 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
38	ROSMAP	Brain Pre-frontal Cortex	ENTPD6	0.32	0.10	bslmm	432	0.12	1.8e-15	5.6	7.0	1.9e-12	0.23	0.52	0.48	TRUE
39	YFS	Blood	ABHD12	0.15	0.35	bslmm	390	0.34	2.2e-118	6.2	6.4	1.8e-10	0.83	0.06	0.94	TRUE
42	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PYGB	0.08	0.04	blup	74	0.06	1.0e-03	6.0	-5.9	4.3e-09	-0.69	0.04	0.86	TRUE
19	GTEx	Esophagus Muscularis	ABHD12	0.10	0.10	enet	42	0.09	4.5e-06	6.0	5.4	7.8e-08	0.67	0.08	0.92	TRUE
8	GTEx	Brain Cerebellar Hemisphere	PYGB	0.20	0.16	lasso	5	0.12	5.8e-04	5.4	-5.2	2.5e-07	-0.65	0.09	0.74	TRUE
2	CommonMind	Brain Pre-frontal Cortex	NINL	0.19	0.17	lasso	20	0.23	1.2e-27	6.1	6.9	4.8e-12	0.83	0.08	0.92	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ABHD12	0.10	0.17	blup	405	0.17	1.7e-20	6.0	6.8	1.0e-11	0.77	0.09	0.91	FALSE
29	GTEx	Pituitary	ABHD12	0.27	0.31	enet	25	0.31	1.8e-08	6.0	6.5	6.5e-11	0.77	0.09	0.91	FALSE
5	GTEx	Artery Aorta	NINL	0.17	0.18	lasso	6	0.19	1.5e-10	6.1	6.4	1.7e-10	0.80	0.07	0.93	FALSE
21	GTEx	Heart Left Ventricle	ABHD12	0.15	0.14	lasso	10	0.12	4.0e-07	6.2	6.4	1.7e-10	0.82	0.06	0.94	FALSE
34	GTEx	Thyroid	NINL	0.13	0.18	enet	17	0.20	6.2e-15	-4.0	-6.3	2.8e-10	-0.72	0.38	0.62	FALSE
15	GTEx	Cells Transformed fibroblasts	ABHD12	0.24	0.33	lasso	4	0.35	6.3e-27	6.2	6.3	3.4e-10	0.81	0.06	0.94	FALSE
7	GTEx	Brain Caudate basal ganglia	ABHD12	0.09	0.05	enet	13	0.04	2.9e-02	6.1	6.3	3.5e-10	0.80	0.07	0.78	FALSE
28	GTEx	Pancreas	ENTPD6	0.11	0.05	enet	23	0.05	5.0e-03	5.6	-6.3	3.6e-10	-0.58	0.10	0.84	FALSE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	ABHD12	0.04	0.06	blup	77	0.06	2.2e-07	6.1	6.2	4.3e-10	0.83	0.07	0.93	FALSE
32	GTEx	Testis	ABHD12	0.21	0.18	enet	25	0.23	1.1e-10	6.1	6.2	5.6e-10	0.71	0.07	0.93	FALSE
25	GTEx	Lung	ABHD12	0.06	0.00	lasso	6	0.00	2.7e-01	5.6	6.1	1.2e-09	0.54	0.12	0.66	FALSE
46	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ABHD12	0.04	0.03	blup	77	0.04	4.0e-05	6.2	6.1	1.3e-09	0.86	0.05	0.95	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	ABHD12	0.26	0.35	enet	35	0.42	7.9e-58	6.0	6.1	1.4e-09	0.69	0.08	0.92	FALSE
45	The Cancer Genome Atlas	Glioblastoma Multiforme	ABHD12	0.14	0.10	lasso	5	0.13	1.1e-04	5.9	6.0	1.7e-09	0.77	0.06	0.89	FALSE
20	GTEx	Heart Atrial Appendage	ABHD12	0.07	0.06	enet	16	0.06	1.0e-03	6.1	6.0	1.9e-09	0.81	0.08	0.91	FALSE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	ABHD12	0.03	0.02	lasso	4	0.03	5.8e-04	-5.8	6.0	2.0e-09	0.71	0.06	0.77	FALSE
33	GTEx	Thyroid	ABHD12	0.05	0.04	lasso	5	0.03	3.9e-03	6.0	-6.0	2.1e-09	-0.80	0.09	0.88	FALSE
12	GTEx	Breast Mammary Tissue	ABHD12	0.08	0.09	lasso	5	0.09	3.3e-05	6.1	6.0	2.2e-09	0.69	0.08	0.89	FALSE
3	GTEx	Adipose Visceral Omentum	ABHD12	0.06	0.00	lasso	8	0.00	4.6e-01	6.1	6.0	2.3e-09	0.65	0.08	0.69	FALSE
6	GTEx	Artery Tibial	ABHD12	0.12	0.12	enet	25	0.15	7.1e-12	6.0	6.0	2.4e-09	0.78	0.10	0.90	FALSE
30	GTEx	Skin Sun Exposed Lower leg	ABHD12	0.07	0.03	lasso	10	0.05	7.3e-05	4.7	6.0	2.4e-09	0.72	0.11	0.87	FALSE
23	GTEx	Liver	ABHD12	0.20	0.20	lasso	19	0.15	7.3e-05	6.0	6.0	2.7e-09	0.81	0.09	0.90	FALSE
16	GTEx	Colon Sigmoid	ABHD12	0.17	0.17	lasso	15	0.17	1.0e-06	5.9	5.9	3.7e-09	0.76	0.09	0.90	FALSE
35	ROSMAP	Brain Pre-frontal Cortex	PYGB	0.20	0.10	bslmm	414	0.11	3.2e-14	5.1	-5.9	3.8e-09	-0.66	0.54	0.46	FALSE
27	GTEx	Nerve Tibial	ABHD12	0.24	0.44	lasso	11	0.44	5.1e-34	6.1	-5.8	5.0e-09	-0.81	0.09	0.91	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	NINL	0.08	0.14	lasso	11	0.13	2.9e-12	6.1	-5.8	6.4e-09	-0.80	0.02	0.98	FALSE
40	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ABHD12	0.04	0.00	blup	77	0.02	6.6e-03	6.1	5.8	6.6e-09	0.85	0.04	0.53	FALSE
10	GTEx	Brain Cortex	ABHD12	0.08	0.11	lasso	8	0.09	1.4e-03	6.2	5.8	8.2e-09	0.78	0.07	0.77	FALSE
51	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ABHD12	0.08	0.09	blup	80	0.09	1.7e-06	6.1	5.8	8.8e-09	0.82	0.06	0.94	FALSE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ABHD12	0.03	0.01	blup	77	0.01	8.7e-03	3.6	5.7	9.0e-09	0.67	0.06	0.75	FALSE
31	GTEx	Spleen	PYGB	0.15	0.09	lasso	6	0.04	2.6e-02	6.0	5.7	9.2e-09	0.84	0.09	0.81	FALSE
50	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ABHD12	0.07	0.05	blup	77	0.05	2.4e-03	6.0	5.7	1.2e-08	0.77	0.05	0.83	FALSE
22	GTEx	Heart Left Ventricle	NINL	0.08	0.03	enet	11	0.05	1.1e-03	6.0	5.7	1.3e-08	0.69	0.14	0.78	FALSE
37	ROSMAP	Brain Pre-frontal Cortex	NINL	0.19	0.19	enet	18	0.25	2.1e-32	6.0	5.7	1.4e-08	0.81	0.07	0.93	FALSE
54	The Cancer Genome Atlas	Testicular Germ Cell Tumors	NINL	0.11	0.03	blup	81	0.07	2.1e-03	-5.9	-5.7	1.4e-08	-0.69	0.03	0.70	FALSE
4	GTEx	Artery Aorta	ABHD12	0.06	0.03	enet	6	0.03	5.4e-03	5.8	5.4	5.5e-08	0.76	0.09	0.86	FALSE
9	GTEx	Brain Cerebellar Hemisphere	ENTPD6	0.22	0.26	lasso	3	0.17	3.8e-05	5.4	-5.4	5.7e-08	-0.77	0.14	0.85	FALSE
52	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ENTPD6	0.07	0.07	lasso	1	0.04	9.2e-03	5.4	-5.4	6.4e-08	-0.77	0.04	0.53	FALSE
13	GTEx	Breast Mammary Tissue (Male)	ABHD12	0.06	0.01	lasso	3	0.02	1.3e-01	4.5	5.4	8.1e-08	0.44	0.05	0.17	FALSE
11	GTEx	Breast Mammary Tissue	CST7	0.10	0.00	lasso	4	0.00	7.3e-01	-4.9	5.4	8.5e-08	0.65	0.08	0.65	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	ABHD12	0.15	0.14	lasso	13	0.14	7.0e-06	5.4	5.3	9.2e-08	0.74	0.08	0.92	FALSE
43	The Cancer Genome Atlas	Colon Adenocarcinoma	NINL	0.20	0.06	lasso	4	0.08	2.7e-05	4.2	5.3	1.1e-07	0.76	0.12	0.77	FALSE
55	The Cancer Genome Atlas	Thyroid Carcinoma	ENTPD6	0.16	0.14	lasso	4	0.13	1.2e-12	5.4	-5.3	1.3e-07	-0.76	0.07	0.93	FALSE
44	The Cancer Genome Atlas	Esophageal Carcinoma	LOC100134868	0.14	0.11	lasso	2	0.10	4.6e-04	-5.4	-5.3	1.4e-07	-0.51	0.00	0.89	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	PYGB	0.38	0.08	lasso	5	0.06	7.0e-03	5.4	5.2	2.0e-07	0.65	0.11	0.74	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	PYGB	0.10	0.08	lasso	7	0.07	1.4e-07	4.4	-5.2	2.1e-07	-0.44	0.80	0.19	FALSE
18	GTEx	Esophagus Mucosa	ENTPD6	0.09	0.04	enet	20	0.06	4.2e-05	6.0	-5.2	2.2e-07	-0.55	0.10	0.89	FALSE
26	GTEx	Lung	NINL	0.07	0.05	lasso	4	0.04	5.3e-04	-4.0	-5.2	2.2e-07	-0.72	0.09	0.90	FALSE
41	The Cancer Genome Atlas	Breast Invasive Carcinoma	PYGB	0.08	0.02	enet	7	0.03	1.7e-07	4.9	-5.2	2.2e-07	-0.51	0.87	0.10	FALSE
47	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GINS1	0.03	0.01	enet	13	0.02	4.3e-03	3.0	5.1	2.9e-07	0.87	0.03	0.67	FALSE
24	GTEx	Liver	APMAP	0.20	-0.01	lasso	9	0.00	3.8e-01	6.0	5.1	3.1e-07	0.59	0.08	0.61	FALSE