Best TWAS P=6.11e-12 · Best GWAS P=5.05e-13 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DNAJC11 | 0.03 | 0.03 | lasso | 5 | 0.04 | 3.1e-05 | 5.2 | 6.3 | 4.0e-10 | -0.78 | 0.03 | 0.96 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | PLEKHG5 | 0.09 | 0.06 | enet | 28 | 0.05 | 3.1e-07 | 4.3 | 5.2 | 1.6e-07 | -0.62 | 0.75 | 0.24 | FALSE |
| 3 | CommonMind | Brain Pre-frontal Cortex | TNFRSF25 | 0.09 | 0.03 | enet | 22 | 0.06 | 1.1e-07 | 4.3 | 5.4 | 5.6e-08 | -0.29 | 0.14 | 0.76 | FALSE |
| 4 | GTEx | Breast Mammary Tissue | GPR153 | 0.13 | 0.03 | lasso | 5 | 0.01 | 1.3e-01 | 5.2 | -5.5 | 5.0e-08 | 0.50 | 0.12 | 0.10 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Female) | GPR153 | 0.07 | -0.01 | enet | 3 | 0.00 | 4.3e-01 | 5.2 | -5.1 | 3.0e-07 | 0.51 | 0.04 | 0.09 | FALSE |
| 6 | GTEx | Heart Left Ventricle | THAP3 | 0.12 | 0.07 | lasso | 7 | 0.09 | 1.9e-05 | -5.5 | 6.0 | 1.7e-09 | -0.91 | 0.05 | 0.93 | FALSE |
| 7 | GTEx | Testis | THAP3 | 0.22 | 0.19 | lasso | 5 | 0.22 | 3.1e-10 | 5.2 | 6.4 | 1.3e-10 | -0.72 | 0.29 | 0.71 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | THAP3 | 0.06 | 0.02 | blup | 51 | 0.03 | 2.8e-04 | -6.4 | 5.2 | 1.6e-07 | -0.87 | 0.01 | 0.97 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DNAJC11 | 0.02 | 0.00 | blup | 74 | 0.01 | 9.1e-03 | 5.2 | 6.1 | 8.7e-10 | -0.74 | 0.03 | 0.54 | FALSE |
| 10 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | THAP3 | 0.08 | 0.04 | enet | 7 | 0.04 | 3.7e-03 | -6.8 | 5.6 | 1.7e-08 | -0.89 | 0.02 | 0.89 | FALSE |
| 11 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | THAP3 | 0.05 | 0.04 | blup | 51 | 0.05 | 4.4e-06 | -6.4 | 6.9 | 6.1e-12 | -0.96 | 0.01 | 0.99 | TRUE |