Hub : Genes

PLEKHG5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0870	0.0280	1.9e-05	0.055	0.047	0.055	0.047	0.054	2.5e-07	2.0e-06	3.1e-07	1.9e-06	3.1e-07
2	GTEx	Cells Transformed fibroblasts	0.1490	0.0650	6.5e-03	0.134	NA	0.092	NA	0.119	2.9e-10	NA	2.1e-07	NA	3.2e-09
3	ROSMAP	Brain Pre-frontal Cortex	0.0943	0.0410	6.1e-04	0.102	0.031	0.100	0.095	0.095	5.0e-13	6.4e-05	8.2e-13	2.8e-12	2.9e-12
4	TCGA	Pheochromocytoma and Paraganglioma	0.1410	0.0750	1.3e-03	0.075	0.042	0.042	NA	0.070	6.3e-04	8.9e-03	9.0e-03	NA	9.3e-04
5	TCGA	Prostate Adenocarcinoma	0.1409	0.0641	5.5e-07	0.032	0.082	0.075	NA	0.068	2.4e-04	6.1e-09	2.7e-08	NA	1.3e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	2.5	4.0	11.5	-3.4	0.0	-2.9	0.0	0.2
Bipolar Disorder or Schizophrenia	3.9	9.6	21.9	-4.7	2.1	-4.3	0.0	1.7
Depressed Affect (Nagel 2018)	0.4	0.8	3.0	0.3	-0.2	1.7	0.0	-1.0
Depression (Nagel 2018)	0.5	0.7	1.7	-1.3	-0.9	0.3	0.0	-1.1
Intelligence (Savage-Jansen 2018)	1.0	2.9	7.8	2.8	-1.6	2.0	0.0	-0.4
Neuroticism (Nagel 2018)	0.5	1.2	3.7	0.8	-0.6	1.9	0.0	-1.1
Schizophrenia (2018)	1.8	3.8	8.6	-2.9	0.4	-2.7	0.0	1.7
Schizophrenia vs Biploar Disorder	0.0	0.0	0.2	-0.1	0.0	-0.4	0.0	0.2
Worry (Nagel 2018)	0.7	1.5	3.2	1.3	-1.1	1.3	0.0	-1.8
Alzheimer’s Disease (in mother)	0.9	1.0	3.7	-1.9	0.5	-0.9	-0.1	-0.7
Alzheimer’s Disease (in father)	0.1	0.1	0.3	-0.3	-0.1	-0.3	0.0	-0.5
Alzheimer’s Disease (including proxy)	0.8	1.1	5.1	-2.3	0.1	-0.6	0.2	-0.3
Crohns Disease (2017)	0.5	1.1	4.0	-0.0	1.2	-0.1	0.0	2.0
Irritable Bowel Disease (IBD)	0.5	1.1	3.3	-0.2	1.4	-0.5	0.0	1.8
Ulcerative Colitis (UC)	0.3	0.5	1.5	-0.1	1.0	-0.1	0.0	1.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	1.2	2.2	6.3	-1.1	0.5	0.1	2.5	1.9
Verbal and Numeric Reasoning (VNR)	0.9	2.1	5.2	2.3	-1.3	1.7	-0.8	-0.2
Breast Cancer	0.3	0.7	1.9	0.6	-1.1	1.4	0.1	0.5
Ovarian Cancer	0.4	0.6	1.5	-1.2	0.9	-0.1	0.6	-0.1
Prostate Cancer	0.3	0.4	1.7	0.6	-1.3	-0.0	-0.2	0.1
Age at First Birth	1.2	1.8	4.5	-0.8	-2.1	-0.9	-0.5	-1.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.3	1.8	3.5	1.6	0.0	1.9	0.0	-1.7
Coronary Artery Disease (CAD)	0.2	0.3	0.7	-0.2	0.0	-0.7	0.0	0.8
Crohns Disease (2012)	0.2	0.4	1.9	-0.0	0.0	0.1	0.0	1.4
Mean Putamen Volume	1.8	2.1	3.6	-1.8	1.8	-1.9	0.0	0.5
Fasting Glucose	0.4	0.5	1.9	0.2	-1.4	0.2	0.6	-0.4
HbA1C	2.7	3.0	4.6	1.8	-1.5	1.6	-1.5	-2.2
HDL Cholesterol	0.5	0.9	2.2	-1.5	0.6	-1.2	0.0	0.7
LDL Cholesterol	0.9	1.4	3.9	0.8	-1.4	0.8	0.0	-2.0
Lupus	2.5	3.8	11.3	1.2	-3.4	1.6	-1.5	-1.2
Neuroticism (2016)	0.7	1.1	3.6	-1.0	0.9	-0.1	0.2	-1.9
Primary Biliary Cirrhosis	0.6	0.9	1.7	1.0	0.0	1.3	0.0	-1.3
Rheumatoid Arthritis	0.2	0.2	0.6	-0.6	0.0	-0.8	0.0	0.5
Schizophrenia (2014)	1.2	2.7	5.0	-2.2	0.5	-2.2	0.0	1.8
Triglycerides	0.7	1.1	1.9	1.4	-0.6	1.4	0.0	-1.1
Type 2 Diabetes (T2D) (2012)	2.1	2.4	5.8	2.4	0.0	2.3	0.0	-1.0
Ulcerative Colitis	0.1	0.1	0.3	-0.5	0.0	-0.3	0.0	-0.2
Blood Eosinophil Count	1.0	7.4	18.2	1.5	-1.1	2.1	-4.3	-3.3
Blood Platelet Count	0.9	10.5	17.0	3.5	-1.1	3.4	-4.1	-3.2
Blood Red Count	0.1	1.2	4.4	-0.7	0.8	-0.3	2.1	0.5
Blood White Count	0.3	2.5	6.3	0.8	-1.4	1.6	-2.5	-0.9
Heel T-Score	3.0	23.9	63.7	8.0	-0.6	5.1	-4.3	-3.3
BMI	1.9	11.2	23.9	4.9	-0.7	4.1	-3.3	-1.9
Height	0.6	11.8	26.6	-3.6	-0.6	-1.9	5.2	3.9
Waist Hip Ratio (WHR)	0.6	2.5	5.6	1.1	-2.4	1.7	1.7	-0.1
Systolic Blood Pressure	1.6	8.3	24.8	5.0	1.9	2.8	-1.9	-1.2
Smoking Status	1.8	4.4	10.6	-1.5	0.2	-1.2	2.8	3.2
Allergy or Eczema	0.8	2.0	4.9	-1.1	1.0	0.3	-2.2	-1.6
Cardiovascular Disease	2.4	7.8	24.6	5.0	-0.7	3.1	-1.7	-1.2
Hypothyroidism (self reported)	0.1	0.3	0.5	0.2	-0.7	0.2	0.5	0.7
Respiratory disease	0.4	0.9	2.1	-1.2	-0.6	0.4	-0.6	-1.5
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.5	0.9	-0.3	1.5	-0.8	-1.6
Lung FEV1/FVC ratio	4.8	24.4	69.7	8.3	-2.8	5.4	-3.3	-2.2
Lung FVC	0.2	0.9	2.5	-1.1	0.4	-1.6	0.7	0.2
Neuroticism	0.2	0.5	1.7	-0.0	0.1	1.3	0.7	-0.2
Chronotype (morning person)	0.3	0.8	1.6	0.5	1.3	-0.2	1.0	1.0
Hair Pigment	0.1	2.4	5.1	-2.2	-0.3	-1.1	1.8	1.6
Tanning	0.2	2.0	6.4	-1.6	1.1	-2.5	-0.0	0.3
Hand grip strength (left)	0.1	0.3	0.5	-0.3	-0.6	-0.6	-0.3	0.7
Number of treatments/medications taken	0.3	0.6	2.3	-0.1	1.5	0.6	0.1	-0.6
Average weekly spirits intake	0.1	0.1	0.4	-0.6	-0.1	-0.3	-0.4	0.0
Sensitivity / hurt feelings	0.7	1.1	2.7	1.1	0.6	1.6	0.2	-1.1
Frequency of depressed mood in last 2 weeks	0.9	1.2	2.5	-1.4	-0.3	0.1	-1.6	-1.3
Hearing difficulty/problems: Yes	1.8	2.7	5.4	-2.3	0.5	-2.1	1.2	1.4
Relative age of first facial hair	0.8	1.6	3.9	-0.7	1.1	-0.3	2.0	1.5
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.9	-1.0	-1.4	0.7	0.7	0.4
Ever used hormone-replacement therapy (HRT)	0.4	0.6	1.2	-0.8	0.6	-0.6	-1.1	-0.5
Ever had hysterectomy (womb removed)	1.6	1.8	7.4	-0.4	2.7	0.6	-1.0	-0.5
Systolic blood pressure, automated reading	2.0	5.8	15.0	3.9	1.5	3.1	-1.3	-0.6
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	-0.6	0.2	-0.7	-0.3	-0.6
Angina	1.3	1.7	3.4	1.1	1.1	0.9	-1.4	-1.8
Medication for hormone replacement therapy	0.3	0.3	0.6	-0.8	-0.5	0.3	-0.6	-0.6
Vitamin and mineral supplements	0.9	1.3	3.9	2.0	-0.6	1.4	0.1	-0.4
Supplements: Zinc	2.7	3.0	8.3	-2.9	-1.5	-1.8	0.8	0.7
Medication: Co-codamol	4.3	4.9	14.3	2.7	-0.3	3.8	-1.1	-1.4
Medication: Metformin	0.2	0.3	0.8	0.4	-0.2	0.9	-0.5	-0.5
Diabetes (father)	0.9	1.1	2.2	1.1	1.3	1.5	0.3	-0.7
Diabetes (mother)	2.8	3.6	8.4	2.9	-1.6	1.6	-1.7	-1.2
Severe depression (siblings)	1.5	1.7	4.5	0.4	-1.8	-0.4	-2.1	-0.6
Pack years adult smoking proportion	0.6	0.9	1.7	0.7	-0.7	0.4	1.2	1.3
Impedance of leg (right)	0.2	1.0	2.3	1.5	0.4	1.0	0.9	0.8
Leg fat-free mass (left)	0.1	0.8	1.6	1.0	-0.0	0.9	0.7	1.3
Trunk fat percentage	1.5	6.0	17.7	4.2	0.2	3.4	-0.7	-0.1
Hand grip strength (right)	0.2	0.6	1.1	-1.1	-0.5	-1.1	-0.4	0.6
Townsend deprivation index at recruitment	1.6	2.2	4.7	-1.8	-1.2	-0.9	2.2	0.9
Current tobacco smoking	0.3	0.6	1.5	0.4	0.2	-0.2	1.0	1.2
Average weekly fortified wine intake	0.5	0.6	1.7	0.5	0.2	-0.6	0.7	-1.3
Maternal smoking around birth	0.4	0.6	1.2	-0.7	0.6	-1.1	-0.1	-1.0
Fed-up feelings	0.8	1.4	2.8	1.0	0.0	1.7	1.2	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.8	-0.9	-0.2	-0.3	-1.3	-0.1
Relative age voice broke	0.9	1.4	4.7	-0.0	1.1	0.7	2.2	0.6
Taking other prescription medications	0.6	0.9	1.7	-1.3	-0.8	0.6	1.1	-0.8
Age when periods started (menarche)	0.4	0.9	2.9	-1.1	0.4	0.1	1.7	-0.4
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	2.2	1.5	-0.4	1.4	-0.8	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	2.5	5.7	16.6	4.1	0.3	2.5	-2.3	-0.5
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.4	-0.4	0.3	-1.2	0.9	0.2
Qualifications: CSEs or equivalent	1.4	1.8	5.3	-0.2	-0.1	-0.5	-2.3	-1.9
Serious illness, injury or assault to yourself	0.8	1.0	1.7	-1.3	-0.2	-1.1	0.9	1.1
High blood pressure	1.7	4.7	14.1	3.8	0.2	2.5	-1.5	-0.7
Hayfever, allergic rhinitis or eczema	0.5	1.2	3.1	-0.6	1.2	0.2	-1.8	-1.0
Multivitamins +/- minerals	3.3	4.2	10.7	-3.3	1.3	-2.8	0.3	0.7
Stomach or abdominal pain in last month	0.4	0.5	1.2	-0.6	-0.4	-0.7	1.1	0.0
Supplements: Glucosamine	0.7	0.9	2.2	-1.0	1.5	-1.1	-0.5	0.1
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	4.3	1.7	-0.0	0.7	-1.2	-2.1
Medication: Atenolol	4.2	5.3	12.5	3.5	0.9	2.8	-1.4	-1.8
Medication: Levothyroxine sodium	0.7	1.2	2.3	-0.9	-1.5	-0.3	0.8	1.4
Sitting height	0.8	5.6	11.6	-3.1	1.0	-1.8	3.4	1.6
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.2	0.4	-0.3	0.5	0.1
High blood pressure (mother)	4.4	6.1	15.2	3.8	-0.1	3.9	-0.4	-1.0
Body mass index (BMI)	1.3	5.4	13.7	3.7	-0.5	2.9	-1.9	-0.9
Impedance of leg (left)	0.2	0.9	1.7	1.3	0.4	1.1	1.0	0.4
Leg predicted mass (left)	0.1	0.8	1.6	1.0	-0.1	1.0	0.6	1.2
Trunk fat mass	1.3	5.4	15.5	3.9	0.0	3.3	-0.5	0.2
Waist circumference	1.4	5.0	12.5	3.4	-1.0	3.5	-0.2	-0.3
Number of incorrect matches in round	0.3	0.6	1.8	-0.2	-1.3	0.4	-0.8	-0.5
Past tobacco smoking	1.5	2.7	6.7	1.1	-0.3	0.4	-2.6	-2.3
Alcohol usually taken with meals	0.1	0.2	0.6	0.4	-0.1	0.2	0.5	-0.8
Nervous feelings	1.4	2.6	5.6	1.2	-1.7	1.3	-1.1	-2.4
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	3.0	-1.7	-0.7	-0.3	-0.4	-1.0
Hearing difficulty/problems with background noise	4.8	7.7	13.9	-3.7	1.1	-3.2	2.2	2.9
Hair/balding pattern: Pattern 2	0.4	0.5	1.0	0.3	-1.0	0.7	0.7	0.4
Had menopause	0.9	1.1	3.0	-1.7	0.9	-0.9	0.6	0.6
Had other major operations	0.9	1.1	1.6	-1.0	0.8	-1.1	0.9	1.3
Forced vital capacity (FVC)	0.7	2.8	4.6	-2.0	0.0	-2.1	2.1	1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.7	11.5	3.4	1.0	1.4	-2.0	0.1
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	3.8	-1.1	1.9	-0.9	-1.4	-0.4
Qualifications: None of the above	0.9	1.9	3.3	1.6	-1.8	1.7	0.0	-1.0
Financial difficulties in last 2 years	0.1	0.1	0.4	0.7	0.0	0.5	0.1	-0.1
Mouth/teeth dental problems	0.1	0.2	0.8	0.9	-0.2	-0.3	0.2	-0.5
Heart attack	0.3	0.3	1.0	0.6	1.0	0.4	0.3	-0.2
Allergy	0.6	1.3	2.5	1.1	-0.5	0.4	1.6	1.5
Pain all over the body in last month	1.0	1.1	2.5	1.1	0.5	1.2	-0.1	1.6
Diabetes (self-reported)	0.4	0.6	1.7	0.6	-1.0	1.3	0.2	-0.4
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.6	-1.2	1.6	-0.8	0.8	0.6
Medication: Ramipril	1.0	1.3	5.2	2.3	0.4	0.9	-0.2	-0.3
Medication: Simvastatin	1.4	2.1	3.8	1.9	-0.6	1.9	-0.5	-1.5
Fluid intelligence score	0.4	0.8	2.6	1.6	-0.4	0.3	-0.9	0.3
Illnesses of siblings	2.0	2.9	6.5	-2.5	-0.0	-2.2	1.5	1.0
Neuroticism score	0.2	0.4	1.3	0.0	0.4	1.2	0.5	-0.3
Weight	0.5	2.6	7.0	2.7	-0.2	2.4	0.1	0.8
Impedance of arm (right)	0.1	0.7	1.8	1.4	0.2	0.6	0.8	0.6
Arm fat percentage (right)	1.9	7.5	21.6	4.7	-0.4	3.7	-1.4	-0.7
Trunk fat-free mass	0.2	1.2	3.6	-0.4	0.0	0.3	1.4	1.9
Hip circumference	0.6	2.5	6.7	2.6	0.3	2.3	0.1	0.3
Time employed in main current job	1.6	1.8	6.2	0.3	-0.6	1.5	-0.6	-2.5
Alcohol intake versus 10 years previously	0.4	0.6	1.1	-0.9	-0.8	-1.0	0.6	0.2
Father’s age at death	1.0	1.3	4.5	-2.1	-0.5	-0.8	0.7	-0.7
Worrier / anxious feelings	0.6	1.1	2.5	0.9	0.8	1.6	-0.2	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.7	2.7	-1.6	0.5	-0.1	0.5	0.8
Falls in the last year	1.4	1.9	4.3	-2.1	1.1	-1.2	0.4	1.5
Hair/balding pattern: Pattern 3	0.2	0.3	0.4	-0.6	-0.6	0.5	0.4	-0.5
Number of live births	1.8	2.6	7.6	2.1	-0.3	2.7	-0.7	0.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.8	0.4	-0.9	-0.3	0.9	-0.0
Pulse rate	1.2	2.1	9.0	-0.2	-0.4	0.1	1.1	3.0
Happiness	0.6	0.8	1.7	-0.1	0.9	0.5	-1.1	-1.3
Noisy workplace	0.8	0.9	1.5	-1.2	-0.6	0.3	1.2	1.2
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.9	-0.1	0.2	-0.4	1.0	0.7
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	4.7	-1.5	2.2	-1.9	1.0	0.6
Mouth/teeth dental problems: Dentures	1.4	2.4	4.6	-1.3	1.1	0.2	2.1	2.1
Asthma	0.6	1.2	2.2	0.4	-1.0	1.1	-1.2	-1.5
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	2.8	-1.6	1.0	-1.7	1.2	1.3
Medication: Cholesterol lowering	2.3	3.6	9.1	3.0	-0.3	2.5	-1.1	-1.1
Depression (self-reported)	0.7	0.8	3.3	-0.0	-1.8	0.1	-0.2	-0.8
Medication: Lansoprazole	0.5	0.6	1.4	-0.7	0.4	0.1	1.0	1.2
Prospective memory result	0.7	0.9	3.5	0.6	0.5	1.9	0.5	-0.3
Lung cancer (father)	1.4	1.7	3.3	-1.3	-1.8	-0.8	-1.2	-1.1
Illnesses of mother	0.3	0.4	0.9	-0.7	-0.5	-0.9	-0.1	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	3.1	1.0	-1.8	0.1	0.2	-0.3
Pulse wave Arterial Stiffness index	0.8	1.0	4.4	0.4	0.4	0.0	0.0	-2.1
Impedance of arm (left)	0.1	0.6	1.2	0.9	0.4	0.7	1.1	0.4
Arm fat mass (right)	1.3	5.5	15.9	4.0	-0.2	3.3	-0.8	-0.0
Trunk predicted mass	0.2	1.3	3.6	-0.5	0.3	0.3	1.5	1.9
Standing height	0.7	6.9	17.0	-1.9	0.8	-0.9	4.1	3.5
Length of working week for main job	0.5	0.6	1.1	1.0	0.7	0.2	-0.5	-1.0
Exposure to tobacco smoke at home	0.5	0.5	1.7	0.7	-0.6	1.3	0.3	0.0
Breastfed as a baby	0.2	0.2	0.4	-0.5	0.6	0.3	0.5	-0.0
Tense / ‘highly strung’	0.3	0.6	1.9	0.1	-1.4	-0.3	-0.9	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.0	0.2	0.4	1.0	0.4	-0.1
Hair/balding pattern: Pattern 4	0.6	1.5	5.6	0.3	2.4	-0.9	-0.7	-0.7
Birth weight of first child	0.9	1.6	4.4	-2.1	0.8	-0.7	1.0	1.2
Peak expiratory flow (PEF)	1.9	4.3	6.7	2.6	-2.4	1.5	-1.9	-1.9
Pulse wave reflection index	1.1	1.3	3.7	-0.7	0.0	-1.4	-0.8	-1.9
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.2	-0.7	1.4	-0.8	0.5	1.5
Loud music exposure frequency	2.7	2.9	5.1	-1.1	-1.9	-2.2	0.9	2.0
Qualifications: O levels/GCSEs or equivalent	0.7	1.0	2.1	1.3	1.4	1.2	0.3	0.1
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.3	0.7	-1.0	0.4	-1.8	-1.4
Blood clot in the leg (DVT)	1.0	1.3	1.8	-1.1	-0.4	-1.4	-1.3	-1.3
Medication: Paracetamol	0.5	0.9	2.6	-0.8	1.6	-0.6	0.7	0.4
Headache pain in last month	0.6	1.0	3.0	-1.7	0.1	-1.0	-0.0	-1.0
Medication for cholesterol, blood pressure or diabetes	2.0	3.3	6.7	-2.6	-0.3	-1.8	1.5	2.0
Glaucoma (self-reported)	2.2	2.6	6.0	-0.9	2.4	0.3	2.2	1.2
Gout (self-reported)	1.1	1.5	4.0	0.7	-0.6	0.3	-1.7	-2.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.6	-0.3	-0.7	-0.1	0.7	1.3
Medication: Amlodipine	0.9	1.3	3.8	0.5	-0.7	0.6	-2.0	-1.3
Medication: Ventolin 100micrograms inhaler	0.9	1.1	3.5	0.1	-1.9	0.5	-0.8	-1.1
Birth weight	1.1	2.4	6.6	-2.6	-0.3	-0.9	1.9	0.9
Chronic bronchitis/emphysema (mother)	0.7	0.8	3.8	0.3	1.9	-0.3	0.1	-0.2
High blood pressure (siblings)	0.6	0.8	3.3	0.3	0.7	0.0	-1.8	-0.4
Forced vital capacity (FVC), Best measure	0.4	1.5	2.2	-1.0	-1.4	-1.5	1.2	0.8
Body fat percentage	1.9	7.6	21.9	4.7	-0.2	3.9	-1.0	-0.4
Leg fat percentage (right)	2.7	9.9	30.0	5.5	-0.9	3.9	-1.8	-0.5
Arm fat-free mass (right)	0.2	0.8	2.1	0.0	0.4	0.7	1.1	1.4
Exposure to tobacco smoke outside home	0.5	0.7	2.0	-0.9	-0.5	0.6	1.4	0.2
Comparative body size at age 10	2.2	6.0	13.1	3.1	-0.8	1.6	-3.6	-2.1
Number of full brothers	1.5	1.8	4.4	2.1	0.9	1.4	1.2	0.6
Worry too long after embarrassment	0.3	0.5	1.6	0.1	0.6	1.3	0.6	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.9	-1.7	0.6	-0.5	0.8	-0.4
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	-0.5	-0.5	-0.2	-0.4	-0.1
Number of children fathered	0.7	0.8	1.2	-0.6	-1.1	-0.5	1.1	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	3.2	-0.7	0.5	-1.8	0.4	0.9
Age at first live birth	0.4	0.7	1.8	-1.1	-0.1	-1.3	-0.2	0.5
Pulse wave peak to peak time	0.9	1.1	4.9	-0.5	-0.5	-0.2	0.2	2.2
Health satisfaction	0.5	0.7	2.2	-0.6	0.3	0.5	1.5	0.7
Shortness of breath walking on level ground	1.6	1.9	6.1	-0.4	1.4	0.4	2.5	1.1
Qualifications: College or University degree	0.7	2.2	4.3	-1.7	2.1	-1.7	0.4	0.9
Eye problems/disorders: None of the above	2.0	2.3	7.2	1.6	-2.7	0.6	-0.8	-0.9
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.5	-0.4	1.6	-0.2	-0.3	-0.5
Emphysema/chronic bronchitis	0.7	0.8	1.5	-1.2	1.2	-0.5	0.7	0.8
Medication for pain relief, constipation, heartburn	0.2	0.3	0.8	0.3	-0.9	0.2	-0.6	-0.5
Neck or shoulder pain in last month	0.5	0.8	2.0	-0.6	-1.4	1.2	0.1	-0.2
Medication: Blood pressure	3.0	5.4	9.8	3.1	0.8	2.5	-2.1	-2.4
Angina (self-reported)	1.8	2.3	5.1	1.3	0.9	1.0	-1.7	-2.3
Migraine (self-reported)	1.6	2.0	3.9	-1.7	2.0	-1.6	0.7	0.5
Medication: Ibuprofen	1.8	2.2	2.6	-1.6	1.5	-1.5	1.3	1.5
Medication: Allopurinol	0.2	0.3	1.0	0.1	0.2	0.3	-1.0	-0.3
Medication: Omeprazole	0.6	0.8	1.5	0.1	-0.7	1.0	-0.9	-1.2
Medication: Seretide 50 evohaler	0.9	1.0	1.9	0.9	-0.2	1.3	-0.8	-1.4
Mean time to correctly identify matches	0.7	1.4	3.6	-1.0	0.3	0.6	1.9	1.4
Heart disease (mother)	0.5	0.6	2.0	0.2	0.3	0.6	0.6	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.3	2.7	6.4	1.0	-1.0	-0.5	-2.2	-2.5
Whole body fat mass	1.4	5.8	16.7	4.1	-0.1	3.5	-0.4	0.2
Leg fat mass (right)	1.7	6.6	20.2	4.5	-0.3	3.4	-0.9	0.1
Arm predicted mass (right)	0.2	0.8	2.3	-0.0	0.4	0.6	1.2	1.5
Pulse rate, automated reading	0.8	2.6	6.8	1.6	-0.8	2.6	0.4	1.6
Alcohol intake frequency.	0.8	1.9	3.2	1.4	-0.0	1.8	-1.7	-1.2
Comparative height size at age 10	0.6	3.4	9.1	-0.7	1.6	0.1	3.0	2.2
Number of full sisters	1.4	1.7	3.7	-0.2	0.1	1.3	1.7	1.9
Suffer from ‘nerves’	0.2	0.4	1.3	-0.2	-0.6	0.2	0.1	-1.1
Overall health rating	1.3	2.9	11.1	1.6	-0.6	3.3	-0.2	-0.5
Chest pain or discomfort	1.4	2.0	5.0	2.2	0.5	1.9	-0.4	-0.9
Had major operations	0.7	0.8	2.5	-0.4	1.6	0.7	0.6	-0.6
Age at last live birth	0.8	1.1	4.0	0.6	-1.0	0.5	-2.0	0.1
Family relationship satisfaction	0.3	0.3	1.0	-1.0	-0.1	-0.5	-0.7	0.2
Leg pain on walking	0.9	1.1	1.9	-1.4	-0.3	0.9	1.1	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.2	-1.1	0.7	-0.2	-0.3	0.6
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.6	1.1	-0.8	1.3	-0.7	-1.1
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.3	1.3	-0.8	0.8	-1.5	-0.1
Medication: Aspirin	0.3	0.4	0.6	-0.8	0.8	-0.7	0.4	0.5
Supplements: Vitamin C	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.2	-0.1
Knee pain experienced in last month	0.2	0.4	1.0	-0.3	0.4	-0.7	-1.0	0.1
Hypertension (Self-reported)	1.7	4.8	14.4	3.8	-0.3	2.6	-1.5	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.3	-0.5	1.5	0.0	1.1	-0.0
Illnesses of father: Heart disease	1.8	2.5	4.8	2.2	0.7	1.0	-2.2	-1.3
Illnesses of siblings: Diabetes	1.4	1.7	3.9	1.9	-0.4	2.0	0.7	-0.4
Smoking status: Previous	1.4	2.1	4.9	-1.0	1.2	-0.4	2.2	1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.4	-0.2	0.1	-0.1	0.8	1.2
Whole body fat-free mass	0.1	0.8	2.5	0.1	-0.0	0.5	1.0	1.6
Leg fat-free mass (right)	0.1	0.5	1.2	0.4	0.0	0.8	0.8	1.1
Arm fat percentage (left)	1.9	7.5	21.1	4.6	-0.4	3.8	-1.4	-0.7
Average weekly red wine intake	0.2	0.3	0.7	-0.8	0.6	0.6	0.4	0.3
Handedness (chirality/laterality): Left-handed	0.4	0.5	2.3	0.3	1.5	-0.0	0.3	0.2
Mood swings	0.2	0.3	0.9	-0.9	0.4	0.5	0.5	-0.1
Loneliness, isolation	0.4	0.5	0.8	0.3	-0.6	0.8	-0.9	-0.8
Long-standing illness, disability or infirmity	0.2	0.3	1.0	-0.1	-0.4	1.0	0.7	-0.1
Ever had bowel cancer screening	0.4	0.5	0.8	0.4	-0.9	-0.0	-0.9	-0.9
Diabetes diagnosed by doctor	0.5	0.8	1.8	0.8	-0.9	1.4	-0.1	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.3	0.3	-1.5	1.0	-0.7	-1.0
Friendships satisfaction	0.4	0.5	1.3	-1.1	-0.8	-0.6	-0.3	0.3
Qualifications: nursing, teaching	0.3	0.4	0.8	-0.7	0.9	-0.7	-0.3	0.4
Commuting to job workplace: Walk	3.3	3.6	7.4	-2.7	0.3	-0.5	2.6	1.9
Eye problems/disorders: Cataract	0.3	0.3	0.9	-0.3	0.7	0.2	-0.9	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.8	0.4	0.6	0.8	-1.7	-0.4
Medication for cholesterol	0.3	0.5	2.0	-1.4	0.1	-0.7	0.3	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.7	5.4	1.6	-0.3	2.3	-0.7	0.3
Back pain experienced in last month	1.5	2.1	5.6	-1.4	-1.3	1.1	2.4	-0.4
Mineral and other dietary supplements	1.5	2.1	5.3	2.3	-1.3	1.8	0.2	-0.2
Breast cancer (self-reported)	0.9	1.1	2.3	-1.5	-0.7	-1.4	0.8	-0.5
Asthma (self-reported)	0.7	1.3	2.3	0.7	-1.0	1.3	-1.1	-1.5
Osteoporosis (self-reported)	0.3	0.4	0.9	-0.7	-0.2	0.6	-0.3	-0.9
Osteoarthritis (self-reported)	1.1	1.5	3.1	-1.8	0.9	-1.5	0.2	1.0
Medication: Aspirin	0.1	0.2	0.3	-0.4	0.6	-0.5	-0.4	0.2
Medication: Gliclazide	1.4	1.5	2.6	1.3	0.2	1.3	-1.3	-1.6
Illnesses of father: None of the above (group 1)	1.5	1.9	6.0	-1.2	-2.5	-1.2	-0.6	0.3
Smoking status: Current	0.6	0.9	3.1	0.0	-0.0	-0.4	1.2	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	4.5	0.7	-2.1	-0.0	-1.4	-0.6
Whole body water mass	0.1	0.7	2.3	0.0	-0.0	0.6	1.0	1.5
Leg predicted mass (right)	0.1	0.5	1.2	0.4	0.0	0.7	0.8	1.1
Arm fat mass (left)	1.4	5.6	15.9	4.0	-0.2	3.4	-0.9	-0.1
Number of self-reported non-cancer illnesses	0.4	0.7	1.7	1.2	-0.4	1.3	-0.2	-0.4
Average weekly champagne plus white wine intake	0.3	0.3	1.2	-0.5	-0.2	-0.3	1.1	-0.2
Miserableness	0.3	0.5	1.6	-1.3	0.0	0.4	-0.2	-0.8
Guilty feelings	1.2	1.8	4.8	-1.3	0.6	0.5	2.2	1.4
Wears glasses or contact lenses	1.3	1.5	2.8	-1.6	1.7	-0.2	1.5	0.3
Ever taken oral contraceptive pill	0.2	0.3	0.9	-0.2	-0.1	-0.2	-0.9	0.7
Hearing aid user	0.5	0.6	1.0	0.8	0.6	0.9	-0.4	1.0
Mother’s age at death	2.1	2.6	4.6	-2.1	1.1	-1.7	-0.3	-2.0
Financial situation satisfaction	1.3	1.6	3.3	-1.8	-1.1	0.0	1.3	1.3
Tinnitus: Yes, now most or all of the time	1.7	2.0	2.6	-1.6	1.6	-0.6	1.5	1.6
Commuting to job workplace: Public transport	0.7	0.8	1.9	-0.2	0.5	-0.7	1.4	1.1
Eye problems/disorders: Glaucoma	3.1	3.7	7.6	-1.0	2.8	1.0	2.4	1.8
Medication: Blood pressure	0.6	1.2	4.7	2.2	0.3	0.8	0.1	0.8
Pain type(s) experienced in last month: Hip pain	1.2	1.5	4.7	-1.3	-2.2	-0.5	0.8	0.6
Supplements: Fish oil (including cod liver oil)	1.4	1.8	4.0	-2.0	1.2	-1.6	0.9	0.5
High cholesterol (Self-reported)	1.1	2.0	4.5	2.1	-1.2	1.7	-0.4	-1.1
Medication: Bendroflumethiazide	0.6	1.0	3.5	1.9	0.5	0.5	-0.9	0.2
Medication: Paracetamol	0.5	0.8	1.3	-0.9	1.2	-1.0	0.5	0.7
Medication: Lisinopril	0.3	0.4	1.0	0.4	-0.1	1.0	0.7	-0.3
Medication: Atorvastatin	1.5	1.8	5.0	2.2	-0.0	0.9	-1.6	0.8
Illnesses of father: High blood pressure	0.5	0.7	1.8	1.1	0.5	1.4	-0.0	0.0
Alcohol drinker status: Never	1.1	1.4	2.3	0.7	1.0	1.2	1.5	1.2
Ever smoked	0.7	1.2	2.4	-0.6	-1.0	-0.2	1.6	1.5
Basal metabolic rate	0.2	1.0	2.2	0.8	0.0	1.1	0.9	1.5
Leg fat percentage (left)	2.6	9.6	27.5	5.2	-0.8	4.0	-1.7	-0.9
Arm fat-free mass (left)	0.2	0.8	2.2	0.4	0.4	0.8	1.0	1.5
Number of operations (self-reported)	0.7	1.0	2.8	-1.7	-0.2	-0.9	0.5	1.0
Average weekly beer plus cider intake	0.6	0.9	2.2	-0.6	-0.8	-1.5	0.0	1.2
Irritability	0.8	1.3	4.3	1.0	-0.0	0.6	-2.1	-0.9
Risk taking	0.8	1.1	2.4	-1.6	-0.2	-1.2	1.1	0.8
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.3	-0.8	-1.8	0.5	0.1	-1.8
Fractured/broken bones in last 5 years	0.2	0.3	1.0	-0.2	-1.0	0.6	0.0	0.2
Age started oral contraceptive pill	0.6	0.7	3.0	1.7	0.4	0.4	-0.5	0.2
Diastolic blood pressure, automated reading	0.9	2.7	4.9	1.7	2.2	1.5	0.9	1.6
Ever depressed for a whole week	1.0	1.2	1.9	-1.4	1.4	-1.4	-0.7	-0.1
Unable to work because of sickness or disability	1.4	1.9	4.9	-0.4	0.1	1.0	1.8	2.2
Commuting to job workplace: Cycle	2.7	3.2	7.8	-0.4	2.8	-1.1	2.0	1.8
Myopia	0.6	0.8	1.7	-1.3	0.2	-1.3	0.7	0.5
Vascular/heart problems diagnosed by doctor	2.1	5.7	17.1	-4.1	-0.3	-2.6	1.8	1.2
Cholesterol lowering medication	1.5	2.3	5.6	2.4	-0.9	1.7	-1.0	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.4	-0.4	0.5	0.6	0.7	0.5
Pain experienced in last month	1.0	1.7	4.7	1.2	2.2	-0.5	-1.5	0.1
Supplements: Calcium	3.6	4.0	9.0	-3.0	-0.6	-2.5	1.6	1.4
Basal cell carcinoma (self-reported)	1.3	1.6	4.7	0.0	-2.2	-0.5	-1.5	-0.6
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.8	0.7	0.9	0.5	0.1	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.8	-0.9	-0.6	-0.9	-1.3	-1.2
Heart disease (siblings)	3.9	4.7	9.2	3.0	-1.3	2.9	-1.1	-1.8
Alcohol drinker status: Previous	0.8	0.9	3.6	0.4	-0.8	0.3	-1.9	0.3
Pack years of smoking	0.6	0.9	2.1	0.5	-0.4	0.6	1.3	1.5
Impedance of whole body	0.1	0.7	1.6	0.9	0.8	0.6	1.3	0.5
Leg fat mass (left)	1.7	6.6	19.8	4.5	-0.1	3.5	-0.9	-0.0
Arm predicted mass (left)	0.2	0.9	2.2	0.4	0.4	0.9	0.9	1.5