TWAS hub - PLEKHG5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0870	0.0280	1.9e-05	0.055	0.047	0.055	0.047	0.054	2.5e-07	2.0e-06	3.1e-07	1.9e-06	3.1e-07
2	GTEx	Cells Transformed fibroblasts	0.1490	0.0650	6.5e-03	0.134	NA	0.092	NA	0.119	2.9e-10	NA	2.1e-07	NA	3.2e-09
3	ROSMAP	Brain Pre-frontal Cortex	0.0943	0.0410	6.1e-04	0.102	0.031	0.100	0.095	0.095	5.0e-13	6.4e-05	8.2e-13	2.8e-12	2.9e-12
4	TCGA	Pheochromocytoma and Paraganglioma	0.1410	0.0750	1.3e-03	0.075	0.042	0.042	NA	0.070	6.3e-04	8.9e-03	9.0e-03	NA	9.3e-04
5	TCGA	Prostate Adenocarcinoma	0.1409	0.0641	5.5e-07	0.032	0.082	0.075	NA	0.068	2.4e-04	6.1e-09	2.7e-08	NA	1.3e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Lung FEV1/FVC ratio	4.8	24.4	69.7	8.3	-2.8	5.4	-3.3	-2.2
Hearing difficulty/problems with background noise	4.8	7.7	13.9	-3.7	1.1	-3.2	2.2	2.9
High blood pressure (mother)	4.4	6.1	15.2	3.8	-0.1	3.9	-0.4	-1.0
Medication: Co-codamol	4.3	4.9	14.3	2.7	-0.3	3.8	-1.1	-1.4
Medication: Atenolol	4.2	5.3	12.5	3.5	0.9	2.8	-1.4	-1.8
Bipolar Disorder or Schizophrenia	3.9	9.6	21.9	-4.7	2.1	-4.3	0.0	1.7
Heart disease (siblings)	3.9	4.7	9.2	3.0	-1.3	2.9	-1.1	-1.8
Supplements: Calcium	3.6	4.0	9.0	-3.0	-0.6	-2.5	1.6	1.4
Multivitamins +/- minerals	3.3	4.2	10.7	-3.3	1.3	-2.8	0.3	0.7
Commuting to job workplace: Walk	3.3	3.6	7.4	-2.7	0.3	-0.5	2.6	1.9
Eye problems/disorders: Glaucoma	3.1	3.7	7.6	-1.0	2.8	1.0	2.4	1.8
Heel T-Score	3.0	23.9	63.7	8.0	-0.6	5.1	-4.3	-3.3
Medication: Blood pressure	3.0	5.4	9.8	3.1	0.8	2.5	-2.1	-2.4
Diabetes (mother)	2.8	3.6	8.4	2.9	-1.6	1.6	-1.7	-1.2
HbA1C	2.7	3.0	4.6	1.8	-1.5	1.6	-1.5	-2.2
Supplements: Zinc	2.7	3.0	8.3	-2.9	-1.5	-1.8	0.8	0.7
Loud music exposure frequency	2.7	2.9	5.1	-1.1	-1.9	-2.2	0.9	2.0
Leg fat percentage (right)	2.7	9.9	30.0	5.5	-0.9	3.9	-1.8	-0.5
Commuting to job workplace: Cycle	2.7	3.2	7.8	-0.4	2.8	-1.1	2.0	1.8
Leg fat percentage (left)	2.6	9.6	27.5	5.2	-0.8	4.0	-1.7	-0.9
Bipolar Disorder (2018)	2.5	4.0	11.5	-3.4	0.0	-2.9	0.0	0.2
Lupus	2.5	3.8	11.3	1.2	-3.4	1.6	-1.5	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	2.5	5.7	16.6	4.1	0.3	2.5	-2.3	-0.5
Cardiovascular Disease	2.4	7.8	24.6	5.0	-0.7	3.1	-1.7	-1.2
Medication: Cholesterol lowering	2.3	3.6	9.1	3.0	-0.3	2.5	-1.1	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.3	2.7	6.4	1.0	-1.0	-0.5	-2.2	-2.5
Glaucoma (self-reported)	2.2	2.6	6.0	-0.9	2.4	0.3	2.2	1.2
Comparative body size at age 10	2.2	6.0	13.1	3.1	-0.8	1.6	-3.6	-2.1
Type 2 Diabetes (T2D) (2012)	2.1	2.4	5.8	2.4	0.0	2.3	0.0	-1.0
Mother’s age at death	2.1	2.6	4.6	-2.1	1.1	-1.7	-0.3	-2.0
Vascular/heart problems diagnosed by doctor	2.1	5.7	17.1	-4.1	-0.3	-2.6	1.8	1.2
Systolic blood pressure, automated reading	2.0	5.8	15.0	3.9	1.5	3.1	-1.3	-0.6
Illnesses of siblings	2.0	2.9	6.5	-2.5	-0.0	-2.2	1.5	1.0
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	4.7	-1.5	2.2	-1.9	1.0	0.6
Medication for cholesterol, blood pressure or diabetes	2.0	3.3	6.7	-2.6	-0.3	-1.8	1.5	2.0
Eye problems/disorders: None of the above	2.0	2.3	7.2	1.6	-2.7	0.6	-0.8	-0.9
BMI	1.9	11.2	23.9	4.9	-0.7	4.1	-3.3	-1.9
Arm fat percentage (right)	1.9	7.5	21.6	4.7	-0.4	3.7	-1.4	-0.7
Peak expiratory flow (PEF)	1.9	4.3	6.7	2.6	-2.4	1.5	-1.9	-1.9
Body fat percentage	1.9	7.6	21.9	4.7	-0.2	3.9	-1.0	-0.4
Arm fat percentage (left)	1.9	7.5	21.1	4.6	-0.4	3.8	-1.4	-0.7
Schizophrenia (2018)	1.8	3.8	8.6	-2.9	0.4	-2.7	0.0	1.7
Mean Putamen Volume	1.8	2.1	3.6	-1.8	1.8	-1.9	0.0	0.5
Smoking Status	1.8	4.4	10.6	-1.5	0.2	-1.2	2.8	3.2
Hearing difficulty/problems: Yes	1.8	2.7	5.4	-2.3	0.5	-2.1	1.2	1.4
Number of live births	1.8	2.6	7.6	2.1	-0.3	2.7	-0.7	0.5
Angina (self-reported)	1.8	2.3	5.1	1.3	0.9	1.0	-1.7	-2.3
Medication: Ibuprofen	1.8	2.2	2.6	-1.6	1.5	-1.5	1.3	1.5
Illnesses of father: Heart disease	1.8	2.5	4.8	2.2	0.7	1.0	-2.2	-1.3
High blood pressure	1.7	4.7	14.1	3.8	0.2	2.5	-1.5	-0.7
Leg fat mass (right)	1.7	6.6	20.2	4.5	-0.3	3.4	-0.9	0.1
Hypertension (Self-reported)	1.7	4.8	14.4	3.8	-0.3	2.6	-1.5	-0.6
Tinnitus: Yes, now most or all of the time	1.7	2.0	2.6	-1.6	1.6	-0.6	1.5	1.6
Leg fat mass (left)	1.7	6.6	19.8	4.5	-0.1	3.5	-0.9	-0.0
Systolic Blood Pressure	1.6	8.3	24.8	5.0	1.9	2.8	-1.9	-1.2
Ever had hysterectomy (womb removed)	1.6	1.8	7.4	-0.4	2.7	0.6	-1.0	-0.5
Townsend deprivation index at recruitment	1.6	2.2	4.7	-1.8	-1.2	-0.9	2.2	0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.7	11.5	3.4	1.0	1.4	-2.0	0.1
Time employed in main current job	1.6	1.8	6.2	0.3	-0.6	1.5	-0.6	-2.5
Shortness of breath walking on level ground	1.6	1.9	6.1	-0.4	1.4	0.4	2.5	1.1
Migraine (self-reported)	1.6	2.0	3.9	-1.7	2.0	-1.6	0.7	0.5
Severe depression (siblings)	1.5	1.7	4.5	0.4	-1.8	-0.4	-2.1	-0.6
Trunk fat percentage	1.5	6.0	17.7	4.2	0.2	3.4	-0.7	-0.1
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	4.3	1.7	-0.0	0.7	-1.2	-2.1
Past tobacco smoking	1.5	2.7	6.7	1.1	-0.3	0.4	-2.6	-2.3
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	2.8	-1.6	1.0	-1.7	1.2	1.3
Number of full brothers	1.5	1.8	4.4	2.1	0.9	1.4	1.2	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.7	5.4	1.6	-0.3	2.3	-0.7	0.3
Back pain experienced in last month	1.5	2.1	5.6	-1.4	-1.3	1.1	2.4	-0.4
Mineral and other dietary supplements	1.5	2.1	5.3	2.3	-1.3	1.8	0.2	-0.2
Illnesses of father: None of the above (group 1)	1.5	1.9	6.0	-1.2	-2.5	-1.2	-0.6	0.3
Medication: Atorvastatin	1.5	1.8	5.0	2.2	-0.0	0.9	-1.6	0.8
Cholesterol lowering medication	1.5	2.3	5.6	2.4	-0.9	1.7	-1.0	-1.0
Qualifications: CSEs or equivalent	1.4	1.8	5.3	-0.2	-0.1	-0.5	-2.3	-1.9
Waist circumference	1.4	5.0	12.5	3.4	-1.0	3.5	-0.2	-0.3
Nervous feelings	1.4	2.6	5.6	1.2	-1.7	1.3	-1.1	-2.4
Medication: Simvastatin	1.4	2.1	3.8	1.9	-0.6	1.9	-0.5	-1.5
Falls in the last year	1.4	1.9	4.3	-2.1	1.1	-1.2	0.4	1.5
Mouth/teeth dental problems: Dentures	1.4	2.4	4.6	-1.3	1.1	0.2	2.1	2.1
Lung cancer (father)	1.4	1.7	3.3	-1.3	-1.8	-0.8	-1.2	-1.1
Whole body fat mass	1.4	5.8	16.7	4.1	-0.1	3.5	-0.4	0.2
Number of full sisters	1.4	1.7	3.7	-0.2	0.1	1.3	1.7	1.9
Chest pain or discomfort	1.4	2.0	5.0	2.2	0.5	1.9	-0.4	-0.9
Illnesses of siblings: Diabetes	1.4	1.7	3.9	1.9	-0.4	2.0	0.7	-0.4
Smoking status: Previous	1.4	2.1	4.9	-1.0	1.2	-0.4	2.2	1.7
Medication: Gliclazide	1.4	1.5	2.6	1.3	0.2	1.3	-1.3	-1.6
Arm fat mass (left)	1.4	5.6	15.9	4.0	-0.2	3.4	-0.9	-0.1
Supplements: Fish oil (including cod liver oil)	1.4	1.8	4.0	-2.0	1.2	-1.6	0.9	0.5
Unable to work because of sickness or disability	1.4	1.9	4.9	-0.4	0.1	1.0	1.8	2.2
Body Mass Index (BMI) (2010)	1.3	1.8	3.5	1.6	0.0	1.9	0.0	-1.7
Angina	1.3	1.7	3.4	1.1	1.1	0.9	-1.4	-1.8
Body mass index (BMI)	1.3	5.4	13.7	3.7	-0.5	2.9	-1.9	-0.9
Trunk fat mass	1.3	5.4	15.5	3.9	0.0	3.3	-0.5	0.2
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	3.8	-1.1	1.9	-0.9	-1.4	-0.4
Arm fat mass (right)	1.3	5.5	15.9	4.0	-0.2	3.3	-0.8	-0.0
Overall health rating	1.3	2.9	11.1	1.6	-0.6	3.3	-0.2	-0.5
Wears glasses or contact lenses	1.3	1.5	2.8	-1.6	1.7	-0.2	1.5	0.3
Financial situation satisfaction	1.3	1.6	3.3	-1.8	-1.1	0.0	1.3	1.3
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.3	-0.8	-1.8	0.5	0.1	-1.8
Basal cell carcinoma (self-reported)	1.3	1.6	4.7	0.0	-2.2	-0.5	-1.5	-0.6
Reaction Time	1.2	2.2	6.3	-1.1	0.5	0.1	2.5	1.9
Age at First Birth	1.2	1.8	4.5	-0.8	-2.1	-0.9	-0.5	-1.6
Schizophrenia (2014)	1.2	2.7	5.0	-2.2	0.5	-2.2	0.0	1.8
Pulse rate	1.2	2.1	9.0	-0.2	-0.4	0.1	1.1	3.0
Guilty feelings	1.2	1.8	4.8	-1.3	0.6	0.5	2.2	1.4
Pain type(s) experienced in last month: Hip pain	1.2	1.5	4.7	-1.3	-2.2	-0.5	0.8	0.6
Pulse wave reflection index	1.1	1.3	3.7	-0.7	0.0	-1.4	-0.8	-1.9
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.3	0.7	-1.0	0.4	-1.8	-1.4
Gout (self-reported)	1.1	1.5	4.0	0.7	-0.6	0.3	-1.7	-2.0
Birth weight	1.1	2.4	6.6	-2.6	-0.3	-0.9	1.9	0.9
Osteoarthritis (self-reported)	1.1	1.5	3.1	-1.8	0.9	-1.5	0.2	1.0
High cholesterol (Self-reported)	1.1	2.0	4.5	2.1	-1.2	1.7	-0.4	-1.1
Alcohol drinker status: Never	1.1	1.4	2.3	0.7	1.0	1.2	1.5	1.2
Intelligence (Savage-Jansen 2018)	1.0	2.9	7.8	2.8	-1.6	2.0	0.0	-0.4
Blood Eosinophil Count	1.0	7.4	18.2	1.5	-1.1	2.1	-4.3	-3.3
Pain all over the body in last month	1.0	1.1	2.5	1.1	0.5	1.2	-0.1	1.6
Medication: Ramipril	1.0	1.3	5.2	2.3	0.4	0.9	-0.2	-0.3
Father’s age at death	1.0	1.3	4.5	-2.1	-0.5	-0.8	0.7	-0.7
Blood clot in the leg (DVT)	1.0	1.3	1.8	-1.1	-0.4	-1.4	-1.3	-1.3
Ever depressed for a whole week	1.0	1.2	1.9	-1.4	1.4	-1.4	-0.7	-0.1
Pain experienced in last month	1.0	1.7	4.7	1.2	2.2	-0.5	-1.5	0.1
Alzheimer’s Disease (in mother)	0.9	1.0	3.7	-1.9	0.5	-0.9	-0.1	-0.7
Verbal and Numeric Reasoning (VNR)	0.9	2.1	5.2	2.3	-1.3	1.7	-0.8	-0.2
LDL Cholesterol	0.9	1.4	3.9	0.8	-1.4	0.8	0.0	-2.0
Blood Platelet Count	0.9	10.5	17.0	3.5	-1.1	3.4	-4.1	-3.2
Frequency of depressed mood in last 2 weeks	0.9	1.2	2.5	-1.4	-0.3	0.1	-1.6	-1.3
Vitamin and mineral supplements	0.9	1.3	3.9	2.0	-0.6	1.4	0.1	-0.4
Diabetes (father)	0.9	1.1	2.2	1.1	1.3	1.5	0.3	-0.7
Relative age voice broke	0.9	1.4	4.7	-0.0	1.1	0.7	2.2	0.6
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	2.2	1.5	-0.4	1.4	-0.8	-0.6
Had menopause	0.9	1.1	3.0	-1.7	0.9	-0.9	0.6	0.6
Had other major operations	0.9	1.1	1.6	-1.0	0.8	-1.1	0.9	1.3
Qualifications: None of the above	0.9	1.9	3.3	1.6	-1.8	1.7	0.0	-1.0
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.6	-1.2	1.6	-0.8	0.8	0.6
Birth weight of first child	0.9	1.6	4.4	-2.1	0.8	-0.7	1.0	1.2
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.2	-0.7	1.4	-0.8	0.5	1.5
Medication: Amlodipine	0.9	1.3	3.8	0.5	-0.7	0.6	-2.0	-1.3
Medication: Ventolin 100micrograms inhaler	0.9	1.1	3.5	0.1	-1.9	0.5	-0.8	-1.1
Pulse wave peak to peak time	0.9	1.1	4.9	-0.5	-0.5	-0.2	0.2	2.2
Medication: Seretide 50 evohaler	0.9	1.0	1.9	0.9	-0.2	1.3	-0.8	-1.4
Leg pain on walking	0.9	1.1	1.9	-1.4	-0.3	0.9	1.1	1.1
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.6	1.1	-0.8	1.3	-0.7	-1.1
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.3	1.3	-0.8	0.8	-1.5	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.3	0.3	-1.5	1.0	-0.7	-1.0
Breast cancer (self-reported)	0.9	1.1	2.3	-1.5	-0.7	-1.4	0.8	-0.5
Diastolic blood pressure, automated reading	0.9	2.7	4.9	1.7	2.2	1.5	0.9	1.6
Alzheimer’s Disease (including proxy)	0.8	1.1	5.1	-2.3	0.1	-0.6	0.2	-0.3
Allergy or Eczema	0.8	2.0	4.9	-1.1	1.0	0.3	-2.2	-1.6
Relative age of first facial hair	0.8	1.6	3.9	-0.7	1.1	-0.3	2.0	1.5
Fed-up feelings	0.8	1.4	2.8	1.0	0.0	1.7	1.2	1.4
Serious illness, injury or assault to yourself	0.8	1.0	1.7	-1.3	-0.2	-1.1	0.9	1.1
Sitting height	0.8	5.6	11.6	-3.1	1.0	-1.8	3.4	1.6
Noisy workplace	0.8	0.9	1.5	-1.2	-0.6	0.3	1.2	1.2
Pulse wave Arterial Stiffness index	0.8	1.0	4.4	0.4	0.4	0.0	0.0	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	3.2	-0.7	0.5	-1.8	0.4	0.9
Pulse rate, automated reading	0.8	2.6	6.8	1.6	-0.8	2.6	0.4	1.6
Alcohol intake frequency.	0.8	1.9	3.2	1.4	-0.0	1.8	-1.7	-1.2
Age at last live birth	0.8	1.1	4.0	0.6	-1.0	0.5	-2.0	0.1
Irritability	0.8	1.3	4.3	1.0	-0.0	0.6	-2.1	-0.9
Risk taking	0.8	1.1	2.4	-1.6	-0.2	-1.2	1.1	0.8
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.8	-0.9	-0.6	-0.9	-1.3	-1.2
Alcohol drinker status: Previous	0.8	0.9	3.6	0.4	-0.8	0.3	-1.9	0.3
Worry (Nagel 2018)	0.7	1.5	3.2	1.3	-1.1	1.3	0.0	-1.8
Neuroticism (2016)	0.7	1.1	3.6	-1.0	0.9	-0.1	0.2	-1.9
Triglycerides	0.7	1.1	1.9	1.4	-0.6	1.4	0.0	-1.1
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.5	0.9	-0.3	1.5	-0.8	-1.6
Sensitivity / hurt feelings	0.7	1.1	2.7	1.1	0.6	1.6	0.2	-1.1
Supplements: Glucosamine	0.7	0.9	2.2	-1.0	1.5	-1.1	-0.5	0.1
Medication: Levothyroxine sodium	0.7	1.2	2.3	-0.9	-1.5	-0.3	0.8	1.4
Forced vital capacity (FVC)	0.7	2.8	4.6	-2.0	0.0	-2.1	2.1	1.1
Depression (self-reported)	0.7	0.8	3.3	-0.0	-1.8	0.1	-0.2	-0.8
Prospective memory result	0.7	0.9	3.5	0.6	0.5	1.9	0.5	-0.3
Standing height	0.7	6.9	17.0	-1.9	0.8	-0.9	4.1	3.5
Qualifications: O levels/GCSEs or equivalent	0.7	1.0	2.1	1.3	1.4	1.2	0.3	0.1
Chronic bronchitis/emphysema (mother)	0.7	0.8	3.8	0.3	1.9	-0.3	0.1	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.9	-1.7	0.6	-0.5	0.8	-0.4
Number of children fathered	0.7	0.8	1.2	-0.6	-1.1	-0.5	1.1	1.1
Qualifications: College or University degree	0.7	2.2	4.3	-1.7	2.1	-1.7	0.4	0.9
Emphysema/chronic bronchitis	0.7	0.8	1.5	-1.2	1.2	-0.5	0.7	0.8
Mean time to correctly identify matches	0.7	1.4	3.6	-1.0	0.3	0.6	1.9	1.4
Had major operations	0.7	0.8	2.5	-0.4	1.6	0.7	0.6	-0.6
Asthma (self-reported)	0.7	1.3	2.3	0.7	-1.0	1.3	-1.1	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	4.5	0.7	-2.1	-0.0	-1.4	-0.6
Commuting to job workplace: Public transport	0.7	0.8	1.9	-0.2	0.5	-0.7	1.4	1.1
Ever smoked	0.7	1.2	2.4	-0.6	-1.0	-0.2	1.6	1.5
Number of operations (self-reported)	0.7	1.0	2.8	-1.7	-0.2	-0.9	0.5	1.0
Primary Biliary Cirrhosis	0.6	0.9	1.7	1.0	0.0	1.3	0.0	-1.3
Height	0.6	11.8	26.6	-3.6	-0.6	-1.9	5.2	3.9
Waist Hip Ratio (WHR)	0.6	2.5	5.6	1.1	-2.4	1.7	1.7	-0.1
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.9	-1.0	-1.4	0.7	0.7	0.4
Pack years adult smoking proportion	0.6	0.9	1.7	0.7	-0.7	0.4	1.2	1.3
Taking other prescription medications	0.6	0.9	1.7	-1.3	-0.8	0.6	1.1	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	3.0	-1.7	-0.7	-0.3	-0.4	-1.0
Allergy	0.6	1.3	2.5	1.1	-0.5	0.4	1.6	1.5
Hip circumference	0.6	2.5	6.7	2.6	0.3	2.3	0.1	0.3
Worrier / anxious feelings	0.6	1.1	2.5	0.9	0.8	1.6	-0.2	-1.2
Happiness	0.6	0.8	1.7	-0.1	0.9	0.5	-1.1	-1.3
Asthma	0.6	1.2	2.2	0.4	-1.0	1.1	-1.2	-1.5
Hair/balding pattern: Pattern 4	0.6	1.5	5.6	0.3	2.4	-0.9	-0.7	-0.7
Headache pain in last month	0.6	1.0	3.0	-1.7	0.1	-1.0	-0.0	-1.0
High blood pressure (siblings)	0.6	0.8	3.3	0.3	0.7	0.0	-1.8	-0.4
Medication: Omeprazole	0.6	0.8	1.5	0.1	-0.7	1.0	-0.9	-1.2
Comparative height size at age 10	0.6	3.4	9.1	-0.7	1.6	0.1	3.0	2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.3	-0.5	1.5	0.0	1.1	-0.0
Smoking status: Current	0.6	0.9	3.1	0.0	-0.0	-0.4	1.2	1.8
Medication: Blood pressure	0.6	1.2	4.7	2.2	0.3	0.8	0.1	0.8
Medication: Bendroflumethiazide	0.6	1.0	3.5	1.9	0.5	0.5	-0.9	0.2
Average weekly beer plus cider intake	0.6	0.9	2.2	-0.6	-0.8	-1.5	0.0	1.2
Age started oral contraceptive pill	0.6	0.7	3.0	1.7	0.4	0.4	-0.5	0.2
Myopia	0.6	0.8	1.7	-1.3	0.2	-1.3	0.7	0.5
Pack years of smoking	0.6	0.9	2.1	0.5	-0.4	0.6	1.3	1.5
Depression (Nagel 2018)	0.5	0.7	1.7	-1.3	-0.9	0.3	0.0	-1.1
Neuroticism (Nagel 2018)	0.5	1.2	3.7	0.8	-0.6	1.9	0.0	-1.1
Crohns Disease (2017)	0.5	1.1	4.0	-0.0	1.2	-0.1	0.0	2.0
Irritable Bowel Disease (IBD)	0.5	1.1	3.3	-0.2	1.4	-0.5	0.0	1.8
HDL Cholesterol	0.5	0.9	2.2	-1.5	0.6	-1.2	0.0	0.7
Average weekly fortified wine intake	0.5	0.6	1.7	0.5	0.2	-0.6	0.7	-1.3
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.4	-0.4	0.3	-1.2	0.9	0.2
Hayfever, allergic rhinitis or eczema	0.5	1.2	3.1	-0.6	1.2	0.2	-1.8	-1.0
Weight	0.5	2.6	7.0	2.7	-0.2	2.4	0.1	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.7	2.7	-1.6	0.5	-0.1	0.5	0.8
Medication: Lansoprazole	0.5	0.6	1.4	-0.7	0.4	0.1	1.0	1.2
Length of working week for main job	0.5	0.6	1.1	1.0	0.7	0.2	-0.5	-1.0
Exposure to tobacco smoke at home	0.5	0.5	1.7	0.7	-0.6	1.3	0.3	0.0
Medication: Paracetamol	0.5	0.9	2.6	-0.8	1.6	-0.6	0.7	0.4
Exposure to tobacco smoke outside home	0.5	0.7	2.0	-0.9	-0.5	0.6	1.4	0.2
Health satisfaction	0.5	0.7	2.2	-0.6	0.3	0.5	1.5	0.7
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.5	-0.4	1.6	-0.2	-0.3	-0.5
Neck or shoulder pain in last month	0.5	0.8	2.0	-0.6	-1.4	1.2	0.1	-0.2
Heart disease (mother)	0.5	0.6	2.0	0.2	0.3	0.6	0.6	1.4
Diabetes diagnosed by doctor	0.5	0.8	1.8	0.8	-0.9	1.4	-0.1	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.8	0.4	0.6	0.8	-1.7	-0.4
Hearing aid user	0.5	0.6	1.0	0.8	0.6	0.9	-0.4	1.0
Medication: Paracetamol	0.5	0.8	1.3	-0.9	1.2	-1.0	0.5	0.7
Illnesses of father: High blood pressure	0.5	0.7	1.8	1.1	0.5	1.4	-0.0	0.0
Depressed Affect (Nagel 2018)	0.4	0.8	3.0	0.3	-0.2	1.7	0.0	-1.0
Ovarian Cancer	0.4	0.6	1.5	-1.2	0.9	-0.1	0.6	-0.1
Fasting Glucose	0.4	0.5	1.9	0.2	-1.4	0.2	0.6	-0.4
Respiratory disease	0.4	0.9	2.1	-1.2	-0.6	0.4	-0.6	-1.5
Ever used hormone-replacement therapy (HRT)	0.4	0.6	1.2	-0.8	0.6	-0.6	-1.1	-0.5
Maternal smoking around birth	0.4	0.6	1.2	-0.7	0.6	-1.1	-0.1	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.8	-0.9	-0.2	-0.3	-1.3	-0.1
Age when periods started (menarche)	0.4	0.9	2.9	-1.1	0.4	0.1	1.7	-0.4
Stomach or abdominal pain in last month	0.4	0.5	1.2	-0.6	-0.4	-0.7	1.1	0.0
Hair/balding pattern: Pattern 2	0.4	0.5	1.0	0.3	-1.0	0.7	0.7	0.4
Diabetes (self-reported)	0.4	0.6	1.7	0.6	-1.0	1.3	0.2	-0.4
Fluid intelligence score	0.4	0.8	2.6	1.6	-0.4	0.3	-0.9	0.3
Alcohol intake versus 10 years previously	0.4	0.6	1.1	-0.9	-0.8	-1.0	0.6	0.2
Forced vital capacity (FVC), Best measure	0.4	1.5	2.2	-1.0	-1.4	-1.5	1.2	0.8
Age at first live birth	0.4	0.7	1.8	-1.1	-0.1	-1.3	-0.2	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.2	-1.1	0.7	-0.2	-0.3	0.6
Handedness (chirality/laterality): Left-handed	0.4	0.5	2.3	0.3	1.5	-0.0	0.3	0.2
Loneliness, isolation	0.4	0.5	0.8	0.3	-0.6	0.8	-0.9	-0.8
Ever had bowel cancer screening	0.4	0.5	0.8	0.4	-0.9	-0.0	-0.9	-0.9
Friendships satisfaction	0.4	0.5	1.3	-1.1	-0.8	-0.6	-0.3	0.3
Number of self-reported non-cancer illnesses	0.4	0.7	1.7	1.2	-0.4	1.3	-0.2	-0.4
Ulcerative Colitis (UC)	0.3	0.5	1.5	-0.1	1.0	-0.1	0.0	1.2
Breast Cancer	0.3	0.7	1.9	0.6	-1.1	1.4	0.1	0.5
Prostate Cancer	0.3	0.4	1.7	0.6	-1.3	-0.0	-0.2	0.1
Blood White Count	0.3	2.5	6.3	0.8	-1.4	1.6	-2.5	-0.9
Chronotype (morning person)	0.3	0.8	1.6	0.5	1.3	-0.2	1.0	1.0
Number of treatments/medications taken	0.3	0.6	2.3	-0.1	1.5	0.6	0.1	-0.6
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	-0.6	0.2	-0.7	-0.3	-0.6
Medication for hormone replacement therapy	0.3	0.3	0.6	-0.8	-0.5	0.3	-0.6	-0.6
Current tobacco smoking	0.3	0.6	1.5	0.4	0.2	-0.2	1.0	1.2
Number of incorrect matches in round	0.3	0.6	1.8	-0.2	-1.3	0.4	-0.8	-0.5
Heart attack	0.3	0.3	1.0	0.6	1.0	0.4	0.3	-0.2
Illnesses of mother	0.3	0.4	0.9	-0.7	-0.5	-0.9	-0.1	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	3.1	1.0	-1.8	0.1	0.2	-0.3
Tense / ‘highly strung’	0.3	0.6	1.9	0.1	-1.4	-0.3	-0.9	-0.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.6	-0.3	-0.7	-0.1	0.7	1.3
Worry too long after embarrassment	0.3	0.5	1.6	0.1	0.6	1.3	0.6	0.2
Family relationship satisfaction	0.3	0.3	1.0	-1.0	-0.1	-0.5	-0.7	0.2
Medication: Aspirin	0.3	0.4	0.6	-0.8	0.8	-0.7	0.4	0.5
Qualifications: nursing, teaching	0.3	0.4	0.8	-0.7	0.9	-0.7	-0.3	0.4
Eye problems/disorders: Cataract	0.3	0.3	0.9	-0.3	0.7	0.2	-0.9	-0.2
Medication for cholesterol	0.3	0.5	2.0	-1.4	0.1	-0.7	0.3	-0.1
Osteoporosis (self-reported)	0.3	0.4	0.9	-0.7	-0.2	0.6	-0.3	-0.9
Average weekly champagne plus white wine intake	0.3	0.3	1.2	-0.5	-0.2	-0.3	1.1	-0.2
Miserableness	0.3	0.5	1.6	-1.3	0.0	0.4	-0.2	-0.8
Medication: Lisinopril	0.3	0.4	1.0	0.4	-0.1	1.0	0.7	-0.3
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.8	0.7	0.9	0.5	0.1	-0.4
Coronary Artery Disease (CAD)	0.2	0.3	0.7	-0.2	0.0	-0.7	0.0	0.8
Crohns Disease (2012)	0.2	0.4	1.9	-0.0	0.0	0.1	0.0	1.4
Rheumatoid Arthritis	0.2	0.2	0.6	-0.6	0.0	-0.8	0.0	0.5
Lung FVC	0.2	0.9	2.5	-1.1	0.4	-1.6	0.7	0.2
Neuroticism	0.2	0.5	1.7	-0.0	0.1	1.3	0.7	-0.2
Tanning	0.2	2.0	6.4	-1.6	1.1	-2.5	-0.0	0.3
Medication: Metformin	0.2	0.3	0.8	0.4	-0.2	0.9	-0.5	-0.5
Impedance of leg (right)	0.2	1.0	2.3	1.5	0.4	1.0	0.9	0.8
Hand grip strength (right)	0.2	0.6	1.1	-1.1	-0.5	-1.1	-0.4	0.6
Impedance of leg (left)	0.2	0.9	1.7	1.3	0.4	1.1	1.0	0.4
Neuroticism score	0.2	0.4	1.3	0.0	0.4	1.2	0.5	-0.3
Trunk fat-free mass	0.2	1.2	3.6	-0.4	0.0	0.3	1.4	1.9
Hair/balding pattern: Pattern 3	0.2	0.3	0.4	-0.6	-0.6	0.5	0.4	-0.5
Trunk predicted mass	0.2	1.3	3.6	-0.5	0.3	0.3	1.5	1.9
Breastfed as a baby	0.2	0.2	0.4	-0.5	0.6	0.3	0.5	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.0	0.2	0.4	1.0	0.4	-0.1
Arm fat-free mass (right)	0.2	0.8	2.1	0.0	0.4	0.7	1.1	1.4
Medication for pain relief, constipation, heartburn	0.2	0.3	0.8	0.3	-0.9	0.2	-0.6	-0.5
Medication: Allopurinol	0.2	0.3	1.0	0.1	0.2	0.3	-1.0	-0.3
Arm predicted mass (right)	0.2	0.8	2.3	-0.0	0.4	0.6	1.2	1.5
Suffer from ‘nerves’	0.2	0.4	1.3	-0.2	-0.6	0.2	0.1	-1.1
Knee pain experienced in last month	0.2	0.4	1.0	-0.3	0.4	-0.7	-1.0	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.4	-0.2	0.1	-0.1	0.8	1.2
Average weekly red wine intake	0.2	0.3	0.7	-0.8	0.6	0.6	0.4	0.3
Mood swings	0.2	0.3	0.9	-0.9	0.4	0.5	0.5	-0.1
Long-standing illness, disability or infirmity	0.2	0.3	1.0	-0.1	-0.4	1.0	0.7	-0.1
Ever taken oral contraceptive pill	0.2	0.3	0.9	-0.2	-0.1	-0.2	-0.9	0.7
Basal metabolic rate	0.2	1.0	2.2	0.8	0.0	1.1	0.9	1.5
Arm fat-free mass (left)	0.2	0.8	2.2	0.4	0.4	0.8	1.0	1.5
Fractured/broken bones in last 5 years	0.2	0.3	1.0	-0.2	-1.0	0.6	0.0	0.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.4	-0.4	0.5	0.6	0.7	0.5
Arm predicted mass (left)	0.2	0.9	2.2	0.4	0.4	0.9	0.9	1.5
Alzheimer’s Disease (in father)	0.1	0.1	0.3	-0.3	-0.1	-0.3	0.0	-0.5
Ulcerative Colitis	0.1	0.1	0.3	-0.5	0.0	-0.3	0.0	-0.2
Blood Red Count	0.1	1.2	4.4	-0.7	0.8	-0.3	2.1	0.5
Hypothyroidism (self reported)	0.1	0.3	0.5	0.2	-0.7	0.2	0.5	0.7
Hair Pigment	0.1	2.4	5.1	-2.2	-0.3	-1.1	1.8	1.6
Hand grip strength (left)	0.1	0.3	0.5	-0.3	-0.6	-0.6	-0.3	0.7
Average weekly spirits intake	0.1	0.1	0.4	-0.6	-0.1	-0.3	-0.4	0.0
Leg fat-free mass (left)	0.1	0.8	1.6	1.0	-0.0	0.9	0.7	1.3
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.2	0.4	-0.3	0.5	0.1
Leg predicted mass (left)	0.1	0.8	1.6	1.0	-0.1	1.0	0.6	1.2
Alcohol usually taken with meals	0.1	0.2	0.6	0.4	-0.1	0.2	0.5	-0.8
Financial difficulties in last 2 years	0.1	0.1	0.4	0.7	0.0	0.5	0.1	-0.1
Mouth/teeth dental problems	0.1	0.2	0.8	0.9	-0.2	-0.3	0.2	-0.5
Impedance of arm (right)	0.1	0.7	1.8	1.4	0.2	0.6	0.8	0.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.8	0.4	-0.9	-0.3	0.9	-0.0
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.9	-0.1	0.2	-0.4	1.0	0.7
Impedance of arm (left)	0.1	0.6	1.2	0.9	0.4	0.7	1.1	0.4
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	-0.5	-0.5	-0.2	-0.4	-0.1
Whole body fat-free mass	0.1	0.8	2.5	0.1	-0.0	0.5	1.0	1.6
Leg fat-free mass (right)	0.1	0.5	1.2	0.4	0.0	0.8	0.8	1.1
Medication: Aspirin	0.1	0.2	0.3	-0.4	0.6	-0.5	-0.4	0.2
Whole body water mass	0.1	0.7	2.3	0.0	-0.0	0.6	1.0	1.5
Leg predicted mass (right)	0.1	0.5	1.2	0.4	0.0	0.7	0.8	1.1
Impedance of whole body	0.1	0.7	1.6	0.9	0.8	0.6	1.3	0.5
Schizophrenia vs Biploar Disorder	0.0	0.0	0.2	-0.1	0.0	-0.4	0.0	0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Supplements: Vitamin C	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.2	-0.1

Hub : Genes

PLEKHG5

Models

Trait associations