TWAS hub - TNFRSF25

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.090	0.0310	4.3e-05	0.032	0.046	0.059	0.047	0.038	8.5e-05	2.3e-06	1.1e-07	1.9e-06	1.9e-05
2	ROSMAP	Brain Pre-frontal Cortex	0.149	0.0426	3.8e-08	0.084	0.061	0.114	0.117	0.128	5.9e-11	2.4e-08	1.7e-14	8.7e-15	4.2e-16

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
High blood pressure (mother)	13.5	18.9	19.0	4.4	4.3
Hearing difficulty/problems with background noise	8.9	14.2	14.4	-3.8	-3.8
Medication: Cholesterol lowering	8.9	13.8	19.8	4.5	2.8
Cardiovascular Disease	8.4	27.6	42.0	6.5	3.6
Bipolar Disorder or Schizophrenia	8.1	19.8	25.2	-3.8	-5.0
Bipolar Disorder (2018)	7.1	11.2	14.0	-2.9	-3.7
Multivitamins +/- minerals	7.0	8.9	10.7	-2.7	-3.3
Medication for cholesterol, blood pressure or diabetes	6.8	11.3	17.1	-4.1	-2.3
Medication: Co-codamol	6.4	7.4	10.8	2.0	3.3
Medication: Simvastatin	6.4	9.4	11.8	3.4	2.7
Overall health rating	6.4	13.6	16.8	4.1	3.2
Leg fat percentage (left)	6.3	22.9	29.5	5.4	4.0
Hypertension (Self-reported)	6.2	17.2	27.1	5.2	2.7
Medication: Blood pressure	6.1	10.8	14.0	3.7	2.8
Leg fat percentage (right)	6.0	21.9	27.6	5.3	4.0
Vascular/heart problems diagnosed by doctor	6.0	16.2	26.1	-5.1	-2.5
Heart disease (siblings)	6.0	7.4	8.9	2.4	3.0
High blood pressure	5.6	15.5	24.5	5.0	2.5
Diabetes (mother)	5.5	7.1	7.4	2.7	2.6
Medication: Atenolol	5.5	6.8	7.3	2.7	2.5
Supplements: Calcium	5.4	6.0	7.7	-2.8	-2.1
Qualifications: College or University degree	5.1	16.1	21.4	-4.6	-3.3
Lung FEV1/FVC ratio	4.8	24.2	24.3	4.9	4.9
High cholesterol (Self-reported)	4.7	8.3	11.3	3.4	2.3
Waist circumference	4.6	16.7	22.8	4.8	3.3
Body fat percentage	4.6	18.3	23.6	4.9	3.6
Illnesses of siblings: Diabetes	4.4	5.4	6.5	2.5	2.1
Lupus	4.2	6.4	7.7	2.2	2.8
Qualifications: None of the above	4.2	9.0	10.5	3.2	2.7
Leg fat mass (left)	4.2	16.5	23.3	4.8	3.1
Leg fat mass (right)	4.1	15.9	21.8	4.7	3.2
Arm fat percentage (left)	4.1	16.3	21.3	4.6	3.4
Trunk fat percentage	4.0	16.1	21.8	4.7	3.2
Supplements: Glucosamine	3.9	5.1	5.6	-2.1	-2.4
Arm fat percentage (right)	3.9	15.2	19.5	4.4	3.3
Schizophrenia (2014)	3.8	8.5	10.3	-2.6	-3.2
Whole body fat mass	3.7	15.4	21.3	4.6	3.1
Hearing difficulty/problems: Yes	3.6	5.4	6.5	-2.1	-2.6
Systolic Blood Pressure	3.5	17.4	28.1	5.3	2.6
Trunk fat mass	3.5	15.1	21.1	4.6	3.0
Illnesses of mother	3.5	4.3	5.7	-2.4	-1.7
Diabetes diagnosed by doctor	3.5	5.8	8.0	2.8	1.9
Arm fat mass (left)	3.5	14.4	20.3	4.5	2.9
Schizophrenia (2018)	3.4	7.1	8.9	-2.3	-3.0
Mother’s age at death	3.4	4.3	7.3	-2.7	-1.1
Loud music exposure frequency	3.3	3.6	4.9	-1.5	-2.2
Diabetes (self-reported)	3.2	4.9	7.3	2.7	1.6
Body mass index (BMI)	3.1	13.0	18.0	4.2	2.8
Number of live births	3.1	4.4	5.6	1.8	2.4
Arm fat mass (right)	3.1	12.9	18.0	4.2	2.8
Exposure to tobacco smoke at home	3.1	3.4	4.4	2.1	1.6
Number of full sisters	3.1	3.8	6.5	2.5	1.0
Body Mass Index (BMI) (2010)	3.0	4.1	4.5	2.1	1.9
BMI	3.0	17.4	22.0	4.7	3.6
Heel bone mineral density (BMD) T-score, automated (left)	2.9	6.6	8.7	3.0	2.1
Mineral and other dietary supplements	2.9	4.0	5.7	1.5	2.4
Ulcerative Colitis	2.8	4.1	5.7	-2.4	-1.6
Chest pain or discomfort	2.8	4.0	5.2	2.3	1.7
Systolic blood pressure, automated reading	2.7	7.9	9.4	3.1	2.5
Supplements: Zinc	2.7	2.9	3.2	-1.8	-1.6
Forced vital capacity (FVC)	2.6	10.0	14.9	-3.9	-2.3
Illnesses of siblings	2.6	3.7	3.8	-1.9	-1.9
Medication: Ibuprofen (e.g. Nurofen)	2.6	3.3	4.2	-1.5	-2.1
Medication: Blood pressure	2.6	4.9	8.9	3.0	0.9
Reason for reducing amount of alcohol drunk: Health precaution	2.5	2.9	3.2	-1.8	-1.6
Major Depression (MDD)	2.4	3.0	5.9	-2.4	0.0
Heel T-Score	2.4	19.4	20.9	4.6	4.2
Type 2 Diabetes (T2D) (2018)	2.4	4.5	5.6	2.4	1.9
Number of self-reported non-cancer illnesses	2.4	4.1	5.9	2.4	1.6
Ever depressed for a whole week	2.4	2.9	3.2	-1.8	-1.6
Time employed in main current job	2.3	2.7	3.2	1.5	1.8
Cholesterol lowering medication	2.3	3.3	4.0	2.0	1.6
Mean Putamen Volume	2.2	2.5	4.0	-1.0	-2.0
Bilateral oophorectomy (both ovaries removed)	2.2	2.6	2.8	1.5	1.7
Medication: Amlodipine	2.2	3.1	5.3	2.3	0.9
Medication: Ibuprofen	2.2	2.7	3.8	-1.3	-1.9
Commuting to job workplace: Cycle	2.2	2.7	4.6	-0.8	-2.1
HbA1C	2.1	2.4	3.0	1.3	1.7
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	3.0	1.2	1.7
Neuroticism (Nagel 2018)	2.0	4.8	6.5	1.8	2.6
Type 2 Diabetes (T2D) (2012)	2.0	2.3	3.1	1.8	1.2
Alcohol intake frequency.	2.0	4.6	5.7	2.4	1.9
Lung FVC	1.9	9.9	17.6	-4.2	-1.5
Supplements: Fish oil (including cod liver oil)	1.9	2.5	3.7	-1.1	-1.9
Depressed Affect (Nagel 2018)	1.8	3.8	4.6	1.7	2.1
Ulcerative Colitis (UC)	1.8	3.4	4.0	-2.0	-1.7
Fed-up feelings	1.8	3.3	3.9	2.0	1.6
Number of full brothers	1.8	2.3	3.0	1.7	1.2
Angina (self-reported)	1.8	2.3	3.9	2.0	0.9
Verbal and Numeric Reasoning (VNR)	1.7	4.1	4.2	2.0	2.0
Vitamin and mineral supplements	1.7	2.4	2.4	1.5	1.6
Medication: Metformin	1.7	2.4	4.2	2.1	0.8
Hip circumference	1.7	7.3	10.4	3.2	2.0
Eye problems/disorders: None of the above	1.7	2.0	3.2	0.9	1.8
Long-standing illness, disability or infirmity	1.7	2.6	3.6	1.9	1.3
Medication: Bendroflumethiazide	1.7	2.6	4.7	2.2	0.7
HDL Cholesterol	1.6	2.7	2.9	-1.7	-1.6
Medication: Ramipril	1.6	2.0	3.2	1.8	0.9
Neck or shoulder pain in last month	1.6	2.2	3.6	1.9	0.9
Irritable Bowel Disease (IBD)	1.5	3.5	5.1	-1.4	-2.3
Nervous feelings	1.5	2.9	5.0	0.9	2.2
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	2.3	-1.1	-1.5
Medication: Gliclazide	1.5	1.7	2.1	1.5	1.1
Irritability	1.5	2.5	3.5	1.9	1.2
Intelligence (Savage-Jansen 2018)	1.4	4.3	5.3	1.8	2.3
Had menopause	1.4	1.8	2.5	-1.6	-1.1
Weight	1.4	7.1	10.3	3.2	2.0
Forced vital capacity (FVC), Best measure	1.4	5.2	9.2	-3.0	-1.1
Medication: Seretide 50 evohaler	1.4	1.6	1.9	1.1	1.4
Pulse rate, automated reading	1.4	4.5	5.5	2.4	1.9
Breast cancer (self-reported)	1.4	1.7	2.6	-1.6	-0.9
Myopia	1.4	2.0	2.3	-1.5	-1.3
Worry (Nagel 2018)	1.3	2.7	3.7	1.3	1.9
Waist Hip Ratio (WHR)	1.3	5.7	7.6	2.8	1.9
Qualifications: nursing, teaching	1.3	2.0	2.2	-1.5	-1.3
Back pain experienced in last month	1.3	1.9	1.9	1.4	1.4
Asthma (self-reported)	1.3	2.6	3.4	1.3	1.8
Ever used hormone-replacement therapy (HRT)	1.2	1.5	2.6	-1.6	-0.7
Angina	1.2	1.5	2.7	1.7	0.6
Taking other prescription medications	1.2	1.9	2.0	1.3	1.4
Comparative body size at age 10	1.2	3.2	4.7	2.2	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	2.3	-1.5	-0.7
Heart attack/myocardial infarction (self-reported)	1.2	1.6	2.9	1.7	0.5
Heart attack	1.1	1.5	2.8	1.7	0.3
Age at first live birth	1.1	1.9	3.0	-0.8	-1.7
Commuting to job workplace: Walk	1.1	1.2	2.0	-1.4	-0.7
Hearing aid user	1.1	1.2	2.1	1.4	0.6
Unable to work because of sickness or disability	1.1	1.5	2.7	1.6	0.5
Pain experienced in last month	1.1	1.9	2.9	-1.7	-0.9
Blood Eosinophil Count	1.0	7.6	9.1	2.5	3.0
Had other major operations	1.0	1.2	2.1	-0.5	-1.4
Prospective memory result	1.0	1.2	2.0	0.7	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.2	2.3	-1.5	-0.4
Migraine (self-reported)	1.0	1.3	2.2	-0.6	-1.5
Pack years adult smoking proportion	0.9	1.4	2.4	1.5	0.7
Current tobacco smoking	0.9	1.5	3.1	1.8	0.1
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	1.7	0.6	1.3
Pain all over the body in last month	0.9	1.0	1.7	1.3	0.5
Asthma	0.9	1.8	2.4	1.0	1.6
Peak expiratory flow (PEF)	0.9	2.1	3.7	0.7	1.9
Glaucoma (self-reported)	0.9	1.0	2.0	1.4	-0.2
Pulse wave peak to peak time	0.9	1.0	1.1	-1.0	-1.0
Osteoarthritis (self-reported)	0.9	1.2	1.8	-0.8	-1.4
Medication: Paracetamol	0.9	1.3	2.4	-0.5	-1.6
Rheumatoid Arthritis	0.8	1.1	1.5	-0.8	-1.2
Average weekly spirits intake	0.8	1.0	1.8	-1.4	-0.3
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	1.2	1.0	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	3.1	1.8	0.8
Mouth/teeth dental problems	0.8	1.3	2.6	-1.6	-0.2
Worrier / anxious feelings	0.8	1.6	2.5	0.8	1.6
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.6	0.4	1.3
Alcohol drinker status: Never	0.8	1.0	1.8	1.3	0.4
Pack years of smoking	0.8	1.2	2.0	1.4	0.6
Depression (Nagel 2018)	0.7	1.1	1.6	1.3	0.7
Alzheimer’s Disease (in mother)	0.7	0.8	1.3	-1.1	-0.6
Neuroticism (2016)	0.7	0.9	1.1	-0.9	1.0
Triglycerides	0.7	1.2	1.2	1.1	1.1
Number of treatments/medications taken	0.7	1.2	2.0	1.4	0.6
Relative age voice broke	0.7	1.1	1.9	1.4	0.5
Medication: Levothyroxine sodium	0.7	1.2	2.3	-1.5	-0.4
Sitting height	0.7	5.1	7.3	-2.7	-1.7
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.1	-1.5	-0.3
Falls in the last year	0.7	1.0	1.3	-1.1	-0.8
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	4.5	-2.1	-0.4
Tense / ‘highly strung’	0.7	1.1	1.3	1.1	1.0
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	2.6	-1.6	-0.3
Medication for cholesterol	0.7	1.1	2.0	-1.4	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.5	0.4	1.2
Medication: Lisinopril	0.7	1.0	1.3	0.8	1.1
Illnesses of father: High blood pressure	0.7	0.9	1.3	1.2	0.7
Prostate Cancer	0.6	0.8	1.4	-1.2	0.4
Coronary Artery Disease (CAD)	0.6	0.7	0.7	-0.8	-0.8
Primary Biliary Cirrhosis	0.6	0.9	1.6	0.5	1.2
Hand grip strength (left)	0.6	1.7	1.9	-1.4	-1.2
Sensitivity / hurt feelings	0.6	1.0	2.0	0.2	1.4
Qualifications: CSEs or equivalent	0.6	0.9	1.7	1.3	0.2
Mouth/teeth dental problems: Dentures	0.6	1.0	1.8	1.4	-0.5
Pulse wave Arterial Stiffness index	0.6	0.7	0.9	0.8	1.0
Length of working week for main job	0.6	0.6	1.1	-1.0	-0.4
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.1	0.6	1.1
Smoking status: Current	0.6	0.9	1.8	1.4	-0.1
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.4	0.2	1.2
Alzheimer’s Disease (including proxy)	0.5	0.8	1.3	-1.2	-0.4
Crohns Disease (2017)	0.5	1.0	1.8	-0.4	-1.4
Fasting Glucose	0.5	0.5	0.8	0.9	0.5
Respiratory disease	0.5	1.1	1.3	0.9	1.1
Neuroticism	0.5	1.1	1.9	0.6	1.4
Medication for hormone replacement therapy	0.5	0.5	1.0	-1.0	-0.3
Hand grip strength (right)	0.5	1.4	1.6	-1.1	-1.3
Serious illness, injury or assault to yourself	0.5	0.6	0.9	1.0	-0.4
Alcohol usually taken with meals	0.5	0.7	1.4	-1.2	-0.3
Hair/balding pattern: Pattern 2	0.5	0.6	1.0	0.5	1.0
Medication: Omeprazole	0.5	0.5	1.0	0.2	1.0
Leg pain on walking	0.5	0.6	0.8	0.6	0.9
Loneliness, isolation	0.5	0.7	1.1	0.5	1.1
Wears glasses or contact lenses	0.5	0.6	0.7	-0.8	-0.7
Risk taking	0.5	0.7	1.3	-0.4	-1.1
Fractured/broken bones in last 5 years	0.5	0.6	0.7	0.7	0.9
Basal cell carcinoma (self-reported)	0.5	0.6	1.3	-1.1	0.0
Crohns Disease (2012)	0.4	0.7	1.0	-0.6	-1.0
Blood Platelet Count	0.4	5.1	7.9	1.5	2.8
Smoking Status	0.4	1.0	1.3	1.2	-0.8
Chronotype (morning person)	0.4	0.9	1.3	1.1	-0.7
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.0	-0.3	-1.0
Financial difficulties in last 2 years	0.4	0.5	1.0	1.0	0.3
Father’s age at death	0.4	0.6	0.8	-0.9	-0.6
Hair/balding pattern: Pattern 3	0.4	0.5	0.9	0.4	1.0
Qualifications: A levels/AS levels or equivalent	0.4	1.0	1.5	-0.7	-1.2
Medication: Lansoprazole	0.4	0.5	0.9	1.0	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.4	-1.5	0.3
Birth weight of first child	0.4	0.7	1.4	-0.0	-1.2
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.9	-0.2	-0.9
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.1	0.2	1.0
Blood clot in the leg (DVT)	0.4	0.5	0.6	-0.8	-0.5
Medication: Paracetamol	0.4	0.6	1.1	-0.3	-1.1
Gout (self-reported)	0.4	0.5	1.0	0.1	1.0
Wheeze or whistling in the chest in last year	0.4	0.8	0.9	1.0	0.8
Family relationship satisfaction	0.4	0.5	0.6	-0.6	-0.8
Smoking status: Previous	0.4	0.6	1.0	-0.4	-1.0
Friendships satisfaction	0.4	0.5	1.0	-1.0	-0.3
Osteoporosis (self-reported)	0.4	0.5	1.0	-0.1	1.0
Medication: Aspirin	0.4	0.6	1.1	1.1	-0.1
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.8	-0.2	-0.9
Average weekly beer plus cider intake	0.4	0.5	0.8	0.5	-0.9
Schizophrenia vs Biploar Disorder	0.3	0.3	0.5	-0.7	-0.4
Ovarian Cancer	0.3	0.5	0.9	-0.9	-0.2
Blood White Count	0.3	2.2	2.2	1.5	1.5
Diabetes (father)	0.3	0.3	0.4	-0.6	0.5
Number of incorrect matches in round	0.3	0.5	0.9	-1.0	-0.0
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.6	-0.8	-0.4
Standing height	0.3	3.0	3.1	-1.8	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.7	0.4	0.8
Exposure to tobacco smoke outside home	0.3	0.4	0.8	-0.9	0.2
Number of children fathered	0.3	0.3	0.6	-0.8	-0.2
Health satisfaction	0.3	0.4	0.8	0.9	0.1
Emphysema/chronic bronchitis	0.3	0.3	0.6	0.1	-0.7
Suffer from ‘nerves’	0.3	0.5	0.6	-0.6	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.5	0.5	-0.7
Medication: Aspirin	0.3	0.4	0.5	0.7	-0.5
Knee pain experienced in last month	0.3	0.4	0.8	-0.3	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.8	-0.9	-0.3
Illnesses of father: None of the above (group 1)	0.3	0.3	0.4	-0.6	-0.6
Commuting to job workplace: Public transport	0.3	0.4	0.7	0.2	-0.8
Eye problems/disorders: Glaucoma	0.3	0.4	0.7	0.8	-0.1
Medication: Atorvastatin	0.3	0.4	0.8	0.9	-0.1
Basal metabolic rate	0.3	1.4	2.5	1.6	0.6
Number of operations (self-reported)	0.3	0.4	0.5	-0.6	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.6	0.7	0.4
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.7	-0.8	-0.3
Alcohol drinker status: Previous	0.3	0.3	0.5	0.7	0.4
Alzheimer’s Disease (in father)	0.2	0.2	0.3	-0.6	-0.0
Height	0.2	3.8	5.3	-2.3	-1.5
Tanning	0.2	2.0	4.0	-0.0	-2.0
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.3	0.5	0.4
Relative age of first facial hair	0.2	0.4	0.6	-0.5	-0.8
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	-0.3	-0.6
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.3	-0.5	-0.6
Severe depression (siblings)	0.2	0.3	0.4	-0.6	0.4
Leg fat-free mass (left)	0.2	1.3	2.3	1.5	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.3	0.5	-0.5
Age when periods started (menarche)	0.2	0.5	0.6	0.8	0.6
Leg predicted mass (left)	0.2	1.3	2.2	1.5	0.6
Past tobacco smoking	0.2	0.4	0.7	0.5	0.8
Neuroticism score	0.2	0.4	0.9	0.1	0.9
Alcohol intake versus 10 years previously	0.2	0.3	0.5	0.3	-0.7
Pulse rate	0.2	0.4	0.7	0.8	-0.4
Hair/balding pattern: Pattern 4	0.2	0.5	0.8	-0.4	-0.9
Arm fat-free mass (right)	0.2	0.9	1.6	1.3	0.3
Shortness of breath walking on level ground	0.2	0.2	0.4	0.7	-0.1
Medication for pain relief, constipation, heartburn	0.2	0.3	0.6	-0.8	0.3
Age at last live birth	0.2	0.3	0.5	0.7	0.4
Eye problems/disorders: Cataract	0.2	0.3	0.5	-0.0	-0.7
Miserableness	0.2	0.4	0.8	-0.3	0.9
Ever taken oral contraceptive pill	0.2	0.3	0.4	0.6	-0.4
Financial situation satisfaction	0.2	0.2	0.4	0.6	0.1
Arm fat-free mass (left)	0.2	0.9	1.7	1.3	0.3
Age started oral contraceptive pill	0.2	0.2	0.3	0.6	-0.2
Arm predicted mass (left)	0.2	0.9	1.7	1.3	0.4
Reaction Time	0.1	0.2	0.3	-0.1	-0.6
Breast Cancer	0.1	0.3	0.5	-0.1	0.7
LDL Cholesterol	0.1	0.2	0.4	0.2	0.6
Allergy or Eczema	0.1	0.2	0.3	0.3	0.6
Hypothyroidism (self reported)	0.1	0.3	0.5	-0.7	0.4
Hair Pigment	0.1	2.6	3.5	-1.9	-1.3
Impedance of leg (right)	0.1	0.4	0.6	0.4	0.8
Average weekly fortified wine intake	0.1	0.1	0.2	0.5	0.0
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.3	-0.5
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.3	-0.4
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.5	-0.2
Impedance of leg (left)	0.1	0.7	0.9	0.7	0.9
Fluid intelligence score	0.1	0.2	0.2	0.5	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.1	0.3	-0.3
Happiness	0.1	0.1	0.1	0.2	0.4
Noisy workplace	0.1	0.1	0.1	-0.4	0.1
Depression (self-reported)	0.1	0.1	0.1	0.3	0.3
Lung cancer (father)	0.1	0.1	0.2	0.2	0.5
Pulse wave reflection index	0.1	0.1	0.1	-0.3	-0.3
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.1	-0.2	-0.4
High blood pressure (siblings)	0.1	0.2	0.4	0.6	0.2
Worry too long after embarrassment	0.1	0.2	0.3	-0.4	0.6
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.2	-0.4
Medication: Allopurinol	0.1	0.2	0.2	-0.4	0.4
Heart disease (mother)	0.1	0.1	0.1	-0.2	-0.3
Arm predicted mass (right)	0.1	0.8	1.5	1.2	0.1
Comparative height size at age 10	0.1	0.5	0.8	-0.5	-0.9
Had major operations	0.1	0.2	0.3	-0.6	0.2
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.1	-0.2	0.3
Supplements: Vitamin C	0.1	0.1	0.1	-0.3	0.4
Illnesses of father: Heart disease	0.1	0.1	0.2	0.1	0.4
Whole body fat-free mass	0.1	0.3	0.7	0.8	0.1
Leg fat-free mass (right)	0.1	0.7	1.2	1.1	0.3
Average weekly red wine intake	0.1	0.2	0.3	-0.6	0.1
Mood swings	0.1	0.1	0.1	-0.3	0.4
Ever had bowel cancer screening	0.1	0.1	0.1	0.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.5	-0.7	0.2
Whole body water mass	0.1	0.3	0.6	0.8	0.1
Leg predicted mass (right)	0.1	0.7	1.3	1.1	0.3
Average weekly champagne plus white wine intake	0.1	0.1	0.1	-0.3	-0.4
Guilty feelings	0.1	0.2	0.3	-0.5	0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	-0.2	0.4
Ever smoked	0.1	0.2	0.3	-0.4	-0.5
Age at First Birth	0.0	0.1	0.1	-0.3	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Blood Red Count	0.0	0.4	0.5	-0.7	-0.4
Townsend deprivation index at recruitment	0.0	0.0	0.1	0.3	-0.1
Maternal smoking around birth	0.0	0.0	0.1	-0.3	-0.1
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.1	0.3	0.1
Allergy	0.0	0.0	0.1	-0.3	-0.0
Impedance of arm (right)	0.0	0.1	0.1	-0.3	0.3
Trunk fat-free mass	0.0	0.1	0.1	0.3	-0.2
Impedance of arm (left)	0.0	0.1	0.1	-0.1	0.3
Trunk predicted mass	0.0	0.1	0.1	0.3	-0.3
Breastfed as a baby	0.0	0.0	0.0	0.1	0.2
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.1	-0.0	0.3
Headache pain in last month	0.0	0.1	0.1	0.0	-0.3
Birth weight	0.0	0.1	0.2	-0.2	-0.4
Mean time to correctly identify matches	0.0	0.0	0.1	0.2	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.0	-0.1	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.1	0.4	0.1
Handedness (chirality/laterality): Left-handed	0.0	0.1	0.1	-0.3	0.1
Diastolic blood pressure, automated reading	0.0	0.1	0.3	0.5	0.0
Impedance of whole body	0.0	0.1	0.2	0.2	0.5

Hub : Genes

TNFRSF25

Models

Trait associations