Best TWAS P=2.8e-10 · Best GWAS P=1.88e-09 conditioned to 0.116
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Nerve Tibial | PDIA2 | 0.12 | 0.01 | enet | 13 | 0.06 | 4.4e-05 | -5.5 | 5.7 | 1.1e-08 | -0.77 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Nerve Tibial | ARHGDIG | 0.13 | 0.07 | lasso | 2 | 0.07 | 8.0e-06 | -5.8 | 5.6 | 1.7e-08 | -0.74 | 0.01 | 0.97 | FALSE |
| 3 | GTEx | Testis | AXIN1 | 0.36 | 0.29 | lasso | 3 | 0.28 | 4.3e-13 | -5.8 | -5.5 | 5.1e-08 | 0.81 | 0.01 | 0.99 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | PDIA2 | 0.15 | 0.07 | lasso | 8 | 0.10 | 5.2e-13 | -4.8 | -5.7 | 9.6e-09 | 0.77 | 0.04 | 0.96 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AXIN1 | 0.03 | 0.01 | blup | 88 | 0.01 | 7.7e-03 | -5.6 | 6.3 | 2.8e-10 | -0.80 | 0.01 | 0.80 | TRUE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LOC100134368 | 0.03 | 0.00 | enet | 5 | 0.01 | 2.8e-02 | -3.0 | -5.6 | 2.6e-08 | 0.58 | 0.01 | 0.60 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC100134368 | 0.05 | 0.00 | blup | 48 | 0.04 | 2.5e-05 | -4.0 | -5.8 | 7.4e-09 | 0.65 | 0.02 | 0.86 | FALSE |