Best TWAS P=2.34e-11 · Best GWAS P=1.19e-12 conditioned to 0.563
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SLC9A3R2 | 0.15 | 0.09 | enet | 7 | 0.10 | 7.8e-12 | -5.2 | 5.8 | 6.9e-09 | -0.58 | 0.26 | 0.74 | FALSE |
| 2 | METSIM | Adipose | PKD1 | 0.06 | 0.02 | bslmm | 370 | 0.03 | 9.5e-06 | -6.3 | 5.1 | 3.1e-07 | -0.77 | 0.01 | 0.99 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | SLC9A3R2 | 0.16 | 0.11 | lasso | 6 | 0.12 | 6.3e-15 | -6.5 | 6.3 | 2.7e-10 | -0.61 | 0.10 | 0.90 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | MLST8 | 0.22 | 0.18 | lasso | 6 | 0.18 | 7.1e-23 | 4.8 | 5.5 | 3.1e-08 | -0.47 | 1.00 | 0.00 | FALSE |
| 5 | YFS | Blood | MLST8 | 0.12 | 0.06 | bslmm | 326 | 0.06 | 4.3e-20 | -3.9 | 5.5 | 2.9e-08 | -0.37 | 1.00 | 0.00 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CASKIN1 | 0.02 | 0.00 | blup | 38 | 0.01 | 4.5e-02 | 4.5 | -6.2 | 4.9e-10 | 0.45 | 0.03 | 0.04 | TRUE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C16orf79 | 0.05 | 0.01 | lasso | 4 | 0.02 | 1.5e-03 | 4.5 | -5.4 | 7.2e-08 | 0.23 | 0.01 | 0.92 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | CASKIN1 | 0.06 | 0.02 | blup | 38 | 0.04 | 1.5e-04 | -7.0 | -6.0 | 2.1e-09 | 0.80 | 0.00 | 0.97 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | MLST8 | 0.09 | 0.07 | enet | 8 | 0.09 | 9.9e-09 | 5.2 | 5.4 | 5.4e-08 | -0.29 | 0.00 | 1.00 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC9A3R2 | 0.06 | 0.03 | lasso | 5 | 0.03 | 3.7e-04 | -5.2 | 6.7 | 2.3e-11 | -0.59 | 0.09 | 0.65 | TRUE |