[Hub]/) : Traits : Leg fat mass (left) : ← →

chr1:5,611,729-9,571,422

Best TWAS P=1.16e-09 · Best GWAS P=2.06e-09 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
17	YFS	Blood	RERE	0.09	0.15	lasso	4	0.16	5.7e-49	-6.0	6.1	1.2e-09	-0.98	0.01	0.99	TRUE
12	GTEx	Testis	THAP3	0.22	0.19	lasso	5	0.22	3.1e-10	5.3	6.0	2.1e-09	0.09	0.08	0.92	TRUE
16	ROSMAP	Brain Pre-frontal Cortex	RP11-431K24.1	0.16	0.16	bslmm	384	0.17	3.1e-21	-4.9	-5.4	5.8e-08	0.05	0.73	0.27	TRUE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	RERE	0.02	0.03	lasso	2	0.03	4.7e-07	-6.0	6.0	1.7e-09	-0.98	0.01	0.99	FALSE
7	GTEx	Lung	RERE	0.07	0.05	lasso	4	0.05	2.0e-04	-5.9	5.9	2.7e-09	-0.87	0.02	0.98	FALSE
6	GTEx	Esophagus Mucosa	RP5-1115A15.1	0.06	0.06	lasso	4	0.05	3.0e-04	-5.8	5.9	3.3e-09	-0.95	0.04	0.91	FALSE
13	GTEx	Thyroid	RP5-1115A15.1	0.09	0.12	lasso	2	0.09	1.5e-07	-5.9	5.9	3.9e-09	-0.99	0.01	0.99	FALSE
8	GTEx	Lung	RP5-1115A15.1	0.05	0.08	lasso	1	0.07	1.0e-05	-5.9	5.9	4.4e-09	-1.00	0.02	0.97	FALSE
10	GTEx	Skin Not Sun Exposed Suprapubic	RP5-1115A15.1	0.08	0.04	enet	8	0.04	3.0e-03	-5.8	5.9	4.6e-09	-0.95	0.03	0.94	FALSE
14	GTEx	Whole Blood	RERE	0.19	0.15	lasso	4	0.13	2.7e-12	-5.8	5.8	7.5e-09	-0.98	0.02	0.98	FALSE
5	GTEx	Esophagus Mucosa	RERE	0.13	0.16	lasso	3	0.16	7.2e-11	-5.8	5.7	9.0e-09	-0.98	0.02	0.98	FALSE
9	GTEx	Muscle Skeletal	RP5-1115A15.1	0.09	0.07	enet	10	0.06	1.5e-06	-5.8	5.7	1.0e-08	-0.87	0.02	0.98	FALSE
21	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RERE	0.22	0.04	lasso	10	0.08	4.1e-04	-5.8	5.7	1.0e-08	-0.90	0.04	0.90	FALSE
1	CommonMind	Brain Pre-frontal Cortex	DNAJC11	0.03	0.03	lasso	5	0.04	3.1e-05	5.2	5.7	1.2e-08	0.09	0.03	0.96	FALSE
20	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	THAP3	0.05	0.04	blup	51	0.05	4.4e-06	-5.2	5.6	2.2e-08	0.07	0.01	0.99	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	DNAJC11	0.02	0.00	blup	74	0.01	9.1e-03	5.3	5.6	2.8e-08	0.09	0.03	0.58	FALSE
15	NTR	Blood	RERE	0.04	0.04	lasso	8	0.03	2.0e-11	-5.7	5.5	3.3e-08	-0.88	0.02	0.98	FALSE
3	GTEx	Adipose Visceral Omentum	RERE	0.22	0.17	lasso	5	0.17	5.2e-09	-5.8	5.4	5.5e-08	-0.90	0.04	0.96	FALSE
4	GTEx	Breast Mammary Tissue	GPR153	0.13	0.03	lasso	5	0.01	1.3e-01	5.3	-5.4	7.7e-08	-0.08	0.08	0.34	FALSE
11	GTEx	Skin Sun Exposed Lower leg	RERE	0.14	0.05	lasso	8	0.08	4.3e-07	-5.8	5.2	2.1e-07	-0.90	0.02	0.98	FALSE
2	GTEx	Adipose Subcutaneous	RP5-1115A15.1	0.14	0.07	enet	20	0.10	2.6e-08	-5.9	5.1	2.8e-07	-0.88	0.02	0.98	FALSE