Best TWAS P=1.16e-09 · Best GWAS P=2.06e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DNAJC11 | 0.03 | 0.03 | lasso | 5 | 0.04 | 3.1e-05 | 5.2 | 5.7 | 1.2e-08 | 0.09 | 0.03 | 0.96 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | RP5-1115A15.1 | 0.14 | 0.07 | enet | 20 | 0.10 | 2.6e-08 | -5.9 | 5.1 | 2.8e-07 | -0.88 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | RERE | 0.22 | 0.17 | lasso | 5 | 0.17 | 5.2e-09 | -5.8 | 5.4 | 5.5e-08 | -0.90 | 0.04 | 0.96 | FALSE |
| 4 | GTEx | Breast Mammary Tissue | GPR153 | 0.13 | 0.03 | lasso | 5 | 0.01 | 1.3e-01 | 5.3 | -5.4 | 7.7e-08 | -0.08 | 0.08 | 0.34 | FALSE |
| 5 | GTEx | Esophagus Mucosa | RERE | 0.13 | 0.16 | lasso | 3 | 0.16 | 7.2e-11 | -5.8 | 5.7 | 9.0e-09 | -0.98 | 0.02 | 0.98 | FALSE |
| 6 | GTEx | Esophagus Mucosa | RP5-1115A15.1 | 0.06 | 0.06 | lasso | 4 | 0.05 | 3.0e-04 | -5.8 | 5.9 | 3.3e-09 | -0.95 | 0.04 | 0.91 | FALSE |
| 7 | GTEx | Lung | RERE | 0.07 | 0.05 | lasso | 4 | 0.05 | 2.0e-04 | -5.9 | 5.9 | 2.7e-09 | -0.87 | 0.02 | 0.98 | FALSE |
| 8 | GTEx | Lung | RP5-1115A15.1 | 0.05 | 0.08 | lasso | 1 | 0.07 | 1.0e-05 | -5.9 | 5.9 | 4.4e-09 | -1.00 | 0.02 | 0.97 | FALSE |
| 9 | GTEx | Muscle Skeletal | RP5-1115A15.1 | 0.09 | 0.07 | enet | 10 | 0.06 | 1.5e-06 | -5.8 | 5.7 | 1.0e-08 | -0.87 | 0.02 | 0.98 | FALSE |
| 10 | GTEx | Skin Not Sun Exposed Suprapubic | RP5-1115A15.1 | 0.08 | 0.04 | enet | 8 | 0.04 | 3.0e-03 | -5.8 | 5.9 | 4.6e-09 | -0.95 | 0.03 | 0.94 | FALSE |
| 11 | GTEx | Skin Sun Exposed Lower leg | RERE | 0.14 | 0.05 | lasso | 8 | 0.08 | 4.3e-07 | -5.8 | 5.2 | 2.1e-07 | -0.90 | 0.02 | 0.98 | FALSE |
| 12 | GTEx | Testis | THAP3 | 0.22 | 0.19 | lasso | 5 | 0.22 | 3.1e-10 | 5.3 | 6.0 | 2.1e-09 | 0.09 | 0.08 | 0.92 | TRUE |
| 13 | GTEx | Thyroid | RP5-1115A15.1 | 0.09 | 0.12 | lasso | 2 | 0.09 | 1.5e-07 | -5.9 | 5.9 | 3.9e-09 | -0.99 | 0.01 | 0.99 | FALSE |
| 14 | GTEx | Whole Blood | RERE | 0.19 | 0.15 | lasso | 4 | 0.13 | 2.7e-12 | -5.8 | 5.8 | 7.5e-09 | -0.98 | 0.02 | 0.98 | FALSE |
| 15 | NTR | Blood | RERE | 0.04 | 0.04 | lasso | 8 | 0.03 | 2.0e-11 | -5.7 | 5.5 | 3.3e-08 | -0.88 | 0.02 | 0.98 | FALSE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | RP11-431K24.1 | 0.16 | 0.16 | bslmm | 384 | 0.17 | 3.1e-21 | -4.9 | -5.4 | 5.8e-08 | 0.05 | 0.73 | 0.27 | TRUE |
| 17 | YFS | Blood | RERE | 0.09 | 0.15 | lasso | 4 | 0.16 | 5.7e-49 | -6.0 | 6.1 | 1.2e-09 | -0.98 | 0.01 | 0.99 | TRUE |
| 18 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RERE | 0.02 | 0.03 | lasso | 2 | 0.03 | 4.7e-07 | -6.0 | 6.0 | 1.7e-09 | -0.98 | 0.01 | 0.99 | FALSE |
| 19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DNAJC11 | 0.02 | 0.00 | blup | 74 | 0.01 | 9.1e-03 | 5.3 | 5.6 | 2.8e-08 | 0.09 | 0.03 | 0.58 | FALSE |
| 20 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | THAP3 | 0.05 | 0.04 | blup | 51 | 0.05 | 4.4e-06 | -5.2 | 5.6 | 2.2e-08 | 0.07 | 0.01 | 0.99 | FALSE |
| 21 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | RERE | 0.22 | 0.04 | lasso | 10 | 0.08 | 4.1e-04 | -5.8 | 5.7 | 1.0e-08 | -0.90 | 0.04 | 0.90 | FALSE |