[Hub]/) : Traits : Leg fat-free mass (left) :

chr18:20,082,830-21,863,589

Best TWAS P=1.45e-24 · Best GWAS P=2.43e-27 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex C18orf8 0.26 0.35 lasso 6 0.40 1.9e-52 -8.3 -8.5 2.8e-17 0.22 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex NPC1 0.08 0.07 lasso 3 0.08 5.2e-10 7.1 -6.4 1.6e-10 0.12 1.00 0.00 FALSE
3 CommonMind Brain Pre-frontal Cortex RIOK3 0.02 0.01 bslmm 348 0.00 1.8e-01 -6.7 -8.4 3.8e-17 0.44 0.14 0.05 FALSE
4 GTEx Adipose Subcutaneous TMEM241 0.07 0.00 enet 12 0.01 4.1e-02 -5.8 -5.9 4.2e-09 0.33 0.32 0.11 FALSE
5 GTEx Adipose Subcutaneous C18orf8 0.17 0.16 enet 13 0.16 2.6e-13 -8.2 -8.6 6.1e-18 0.23 1.00 0.00 FALSE
6 GTEx Adipose Subcutaneous NPC1 0.27 0.27 enet 12 0.30 2.4e-25 -7.7 -7.9 3.8e-15 0.25 1.00 0.00 FALSE
7 GTEx Adipose Visceral Omentum C18orf8 0.18 0.11 enet 10 0.04 4.5e-03 -8.6 -8.1 5.5e-16 0.30 0.85 0.01 FALSE
8 GTEx Adipose Visceral Omentum NPC1 0.20 0.19 lasso 3 0.17 2.9e-09 -7.7 -7.8 6.0e-15 0.24 1.00 0.00 FALSE
9 GTEx Artery Tibial C18orf8 0.18 0.12 lasso 3 0.10 1.5e-08 7.0 -7.0 3.4e-12 0.14 1.00 0.00 TRUE
10 GTEx Artery Tibial NPC1 0.26 0.07 enet 31 0.11 3.7e-09 7.0 -6.5 7.9e-11 0.02 1.00 0.00 FALSE
11 GTEx Brain Caudate basal ganglia C18orf8 0.15 0.16 enet 11 0.11 5.9e-04 -8.4 -8.5 2.1e-17 0.22 0.44 0.04 FALSE
12 GTEx Brain Cerebellar Hemisphere C18orf8 0.27 0.34 enet 19 0.34 1.3e-09 -8.2 -8.5 1.5e-17 0.24 0.96 0.00 FALSE
13 GTEx Brain Cerebellum C18orf8 0.23 0.18 enet 13 0.21 9.9e-07 -8.2 -8.7 2.3e-18 0.26 0.82 0.04 TRUE
14 GTEx Brain Cerebellum NPC1 0.20 0.10 enet 9 0.12 1.9e-04 -8.2 -7.4 1.7e-13 0.23 0.42 0.05 FALSE
15 GTEx Brain Cortex TMEM241 0.37 0.12 enet 19 0.22 1.3e-06 2.2 -5.8 5.8e-09 0.26 0.67 0.04 FALSE
16 GTEx Brain Cortex C18orf8 0.19 0.18 lasso 5 0.13 1.8e-04 -8.3 -8.3 7.4e-17 0.23 0.48 0.03 TRUE
17 GTEx Brain Frontal Cortex BA9 C18orf8 0.42 0.30 enet 12 0.08 3.4e-03 -8.2 -7.7 1.0e-14 0.22 0.90 0.01 FALSE
18 GTEx Brain Nucleus accumbens basal ganglia TMEM241 0.17 0.02 lasso 6 -0.01 5.6e-01 -8.2 -6.2 7.6e-10 0.24 0.10 0.06 FALSE
19 GTEx Breast Mammary Tissue NPC1 0.27 0.13 enet 27 0.19 5.0e-10 -7.7 -8.1 3.7e-16 0.22 1.00 0.00 FALSE
20 GTEx Breast Mammary Tissue (Female) NPC1 0.43 0.24 lasso 3 0.27 1.1e-08 -7.8 -8.1 4.6e-16 0.26 0.98 0.00 FALSE
21 GTEx Esophagus Gastroesophageal Junction NPC1 0.19 0.13 lasso 5 0.11 1.1e-04 -4.1 -5.4 6.8e-08 0.13 0.45 0.09 FALSE
22 GTEx Esophagus Mucosa NPC1 0.09 0.04 lasso 3 0.05 1.5e-04 -7.7 -8.3 7.8e-17 0.30 0.57 0.02 TRUE
23 GTEx Esophagus Muscularis C18orf8 0.14 0.13 lasso 3 0.10 8.0e-07 7.1 -7.9 3.7e-15 0.17 0.96 0.00 FALSE
24 GTEx Esophagus Muscularis NPC1 0.11 0.07 enet 4 0.09 7.3e-06 -8.6 -8.7 3.2e-18 0.25 0.76 0.01 FALSE
25 GTEx Heart Left Ventricle NPC1 0.19 0.15 enet 12 0.17 1.6e-09 -8.2 -8.2 1.9e-16 0.26 1.00 0.00 FALSE
26 GTEx Lung NPC1 0.11 0.06 enet 11 0.04 2.3e-04 -8.3 -7.9 4.1e-15 0.21 0.99 0.00 FALSE
27 GTEx Nerve Tibial TMEM241 0.16 0.04 enet 10 0.07 1.8e-05 -6.3 -7.5 4.8e-14 0.48 0.70 0.02 FALSE
28 GTEx Nerve Tibial C18orf8 0.16 0.07 enet 21 0.09 3.9e-07 -7.8 -7.6 2.9e-14 0.12 1.00 0.00 FALSE
29 GTEx Nerve Tibial NPC1 0.19 0.12 lasso 6 0.16 1.1e-11 7.1 -8.2 2.6e-16 0.21 1.00 0.00 FALSE
30 GTEx Pancreas NPC1 0.33 0.14 lasso 7 0.12 1.1e-05 -8.2 -7.9 2.3e-15 0.24 0.81 0.01 FALSE
31 GTEx Skin Not Sun Exposed Suprapubic C18orf8 0.21 0.27 enet 6 0.23 6.9e-13 -8.2 -8.3 7.0e-17 0.24 1.00 0.00 FALSE
32 GTEx Skin Not Sun Exposed Suprapubic NPC1 0.15 0.08 lasso 4 0.12 2.3e-07 -8.2 -8.4 4.2e-17 0.23 0.99 0.00 FALSE
33 GTEx Skin Sun Exposed Lower leg C18orf8 0.35 0.33 enet 23 0.36 1.7e-30 -8.4 -8.3 9.1e-17 0.24 1.00 0.00 FALSE
34 GTEx Skin Sun Exposed Lower leg NPC1 0.23 0.18 lasso 3 0.27 1.8e-22 -7.7 -8.1 6.3e-16 0.23 1.00 0.00 FALSE
35 GTEx Testis C18orf8 0.12 0.07 lasso 6 0.08 1.9e-04 -8.2 -10.2 1.4e-24 0.43 0.17 0.45 TRUE
36 GTEx Thyroid NPC1 0.20 0.10 enet 25 0.13 2.3e-10 -8.3 -6.6 3.5e-11 0.10 1.00 0.00 FALSE
37 GTEx Vagina NPC1 0.27 0.09 lasso 7 0.14 4.9e-04 -5.5 -6.4 1.3e-10 0.37 0.23 0.10 FALSE
38 METSIM Adipose C18orf8 0.08 0.02 enet 23 0.04 1.0e-06 7.1 -7.2 5.2e-13 0.26 0.80 0.01 FALSE
39 METSIM Adipose NPC1 0.06 0.05 enet 18 0.05 6.4e-08 -8.4 -7.2 5.3e-13 0.22 1.00 0.00 FALSE
40 The Cancer Genome Atlas Breast Invasive Carcinoma NPC1 0.03 0.03 blup 69 0.04 2.9e-09 -8.2 -7.7 1.4e-14 0.24 0.03 0.97 FALSE
41 The Cancer Genome Atlas Esophageal Carcinoma NPC1 0.16 0.10 lasso 3 0.10 3.7e-04 7.1 -7.9 3.9e-15 0.19 0.05 0.64 FALSE
42 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma NPC1 0.05 0.02 blup 66 0.03 1.4e-04 -8.0 -6.0 1.6e-09 0.24 0.14 0.67 FALSE
43 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma NPC1 0.03 0.04 lasso 2 0.05 4.2e-06 -8.0 -8.4 4.7e-17 0.27 0.02 0.98 FALSE
44 The Cancer Genome Atlas Brain Lower Grade Glioma C18orf45 0.04 0.02 lasso 3 0.03 2.7e-04 5.1 -5.7 1.0e-08 0.34 0.70 0.02 FALSE
45 The Cancer Genome Atlas Brain Lower Grade Glioma C18orf8 0.07 0.05 lasso 5 0.03 9.5e-05 7.0 -7.0 2.5e-12 0.15 0.27 0.71 FALSE
46 The Cancer Genome Atlas Brain Lower Grade Glioma CABLES1 0.06 0.02 enet 12 0.04 6.8e-05 3.2 -5.5 3.5e-08 0.26 0.07 0.03 TRUE
47 The Cancer Genome Atlas Brain Lower Grade Glioma NPC1 0.07 0.08 lasso 3 0.10 1.6e-11 7.0 -8.4 3.1e-17 0.20 0.03 0.97 TRUE
48 The Cancer Genome Atlas Prostate Adenocarcinoma NPC1 0.05 0.02 blup 65 0.03 9.9e-04 -8.0 -7.3 3.6e-13 0.25 0.02 0.77 FALSE
49 The Cancer Genome Atlas Thyroid Carcinoma NPC1 0.04 0.03 blup 70 0.05 9.4e-06 -8.2 -7.2 8.1e-13 0.21 0.03 0.96 TRUE