Best TWAS P=3.97e-10 · Best GWAS P=2.34e-10 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | TMOD3 | 0.17 | 0.02 | enet | 11 | 0.05 | 7.1e-04 | -5.2 | -5.4 | 5.9e-08 | 0.90 | 0.08 | 0.90 | FALSE |
2 | GTEx | Cells EBV-transformed lymphocytes | DMXL2 | 0.17 | 0.13 | lasso | 3 | 0.06 | 4.2e-03 | 5.7 | 5.6 | 2.3e-08 | -0.45 | 0.29 | 0.42 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | DMXL2 | 0.06 | 0.06 | lasso | 3 | 0.05 | 5.9e-05 | 5.6 | -5.5 | 3.2e-08 | 0.27 | 0.59 | 0.26 | TRUE |
4 | GTEx | Cells Transformed fibroblasts | TMOD2 | 0.09 | 0.10 | enet | 8 | 0.10 | 3.0e-08 | -6.1 | -6.2 | 5.5e-10 | 1.00 | 0.03 | 0.97 | FALSE |
5 | GTEx | Muscle Skeletal | LYSMD2 | 0.23 | 0.23 | lasso | 4 | 0.21 | 1.6e-20 | -6.2 | 6.2 | 5.3e-10 | -0.98 | 0.04 | 0.96 | FALSE |
6 | GTEx | Skin Not Sun Exposed Suprapubic | TMOD3 | 0.05 | 0.07 | enet | 13 | 0.07 | 6.4e-05 | -6.3 | 5.9 | 4.0e-09 | -0.98 | 0.05 | 0.94 | FALSE |
7 | GTEx | Skin Sun Exposed Lower leg | TMOD3 | 0.07 | 0.07 | enet | 22 | 0.06 | 6.0e-06 | -6.1 | 6.3 | 4.0e-10 | -0.99 | 0.03 | 0.97 | TRUE |
8 | GTEx | Thyroid | MAPK6 | 0.04 | 0.02 | lasso | 4 | 0.01 | 8.8e-02 | -5.1 | 5.8 | 9.1e-09 | -0.92 | 0.13 | 0.74 | FALSE |
9 | GTEx | Thyroid | LEO1 | 0.05 | 0.05 | lasso | 3 | 0.04 | 3.7e-04 | -5.3 | 5.2 | 1.6e-07 | -0.91 | 0.22 | 0.73 | FALSE |
10 | METSIM | Adipose | TMOD2 | 0.03 | 0.03 | lasso | 10 | 0.02 | 1.9e-03 | -5.1 | -5.4 | 8.2e-08 | 0.89 | 0.54 | 0.45 | FALSE |
11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TMOD2 | 0.04 | 0.03 | blup | 76 | 0.04 | 5.5e-05 | -5.4 | -5.3 | 1.1e-07 | 0.96 | 0.10 | 0.89 | FALSE |
12 | The Cancer Genome Atlas | Lung Adenocarcinoma | TMOD2 | 0.02 | 0.01 | blup | 78 | 0.02 | 2.3e-03 | -5.4 | -6.1 | 1.4e-09 | 0.98 | 0.03 | 0.85 | FALSE |
13 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | TMOD2 | 0.13 | 0.10 | lasso | 2 | 0.07 | 1.0e-03 | 5.7 | -5.7 | 1.0e-08 | 0.73 | 0.03 | 0.71 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | LEO1 | 0.14 | 0.12 | enet | 7 | 0.13 | 9.2e-13 | -6.3 | 5.3 | 8.7e-08 | -0.93 | 0.00 | 1.00 | FALSE |