TWAS hub - DMXL2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.053	0.0230	0.00450	0.041	0.004	0.017	0.008	0.012	7.9e-06	0.088	2.9e-03	0.03	9.9e-03
2	GTEx	Artery Tibial	0.087	0.0372	0.00370	0.102	NA	0.075	NA	0.093	2.2e-08	NA	1.7e-06	NA	9.0e-08
3	GTEx	Cells EBV-transformed lymphocytes	0.167	0.0760	0.00043	0.130	NA	0.013	NA	0.063	5.2e-05	NA	1.1e-01	NA	4.2e-03
4	GTEx	Cells Transformed fibroblasts	0.063	0.0300	0.00940	0.058	NA	0.054	NA	0.055	3.7e-05	NA	7.1e-05	NA	5.9e-05
5	GTEx	Esophagus Mucosa	0.094	0.0440	0.00390	0.012	NA	0.002	NA	0.004	4.9e-02	NA	2.3e-01	NA	1.7e-01
6	GTEx	Esophagus Muscularis	0.130	0.0470	0.00055	0.075	NA	0.076	NA	0.073	2.6e-05	NA	2.2e-05	NA	3.4e-05
7	GTEx	Muscle Skeletal	0.125	0.0425	0.00011	0.043	NA	0.021	NA	0.032	4.6e-05	NA	3.7e-03	NA	3.8e-04
8	GTEx	Nerve Tibial	0.343	0.0578	0.00000	0.301	NA	0.306	NA	0.308	1.3e-21	NA	4.5e-22	NA	3.0e-22
9	GTEx	Pituitary	0.236	0.0890	0.00240	0.193	NA	0.133	NA	0.146	1.4e-05	NA	3.3e-04	NA	1.7e-04
10	TCGA	Kidney Renal Papillary Cell Carcinoma	0.174	0.1070	0.00540	0.009	0.023	0.029	NA	0.024	9.5e-02	0.017	9.0e-03	NA	1.4e-02
11	TCGA	Pheochromocytoma and Paraganglioma	0.121	0.0760	0.00320	0.047	0.032	0.059	NA	0.056	5.8e-03	0.020	2.2e-03	NA	2.8e-03
12	TCGA	Uterine Corpus Endometrial Carcinoma	0.416	0.1850	0.00980	-0.006	0.025	0.039	NA	0.017	5.0e-01	0.067	3.0e-02	NA	1.0e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Neck or shoulder pain in last month	5.5	7.8	13.0	3.6	1.6	0.4	2.7	2.7	3.3	3.6	3.5	3.2	1.2	3.3	1.7
Number of children fathered	5.0	5.7	9.6	2.9	2.7	-0.3	2.5	2.0	2.5	3.1	2.6	2.3	1.4	2.5	2.3
Medication: Gliclazide	5.0	5.7	13.0	3.6	1.9	1.8	1.3	0.8	3.1	2.4	3.1	3.1	0.2	3.2	1.2
Frequency of tiredness / lethargy in last 2 weeks	4.6	7.4	21.4	0.2	-0.7	4.5	-4.0	-4.6	2.0	-2.3	1.5	2.0	-2.1	2.0	-2.7
Qualifications: A levels/AS levels or equivalent	4.4	9.7	17.5	-4.1	-1.6	-2.1	-2.6	-1.3	-4.1	-3.7	-4.2	-3.8	-2.1	-4.1	-0.7
Pain experienced in last month	4.2	7.1	14.5	-3.5	-1.1	-2.5	-1.0	-0.5	-3.8	-2.4	-3.8	-3.8	-1.0	-3.7	-0.5
Pulse rate	3.8	6.3	11.0	2.9	2.0	1.3	1.7	0.3	3.3	2.8	3.3	3.0	2.4	3.3	1.9
Comparative body size at age 10	3.7	10.3	20.8	-3.9	-2.6	1.4	-4.2	-3.2	-2.6	-4.6	-2.9	-2.6	-3.5	-2.6	-3.1
Qualifications: College or University degree	3.7	11.7	23.0	-3.8	-3.6	0.8	-4.5	-3.9	-3.0	-4.8	-3.2	-2.8	-3.4	-2.8	-2.7
Bilateral oophorectomy (both ovaries removed)	3.5	4.0	6.9	2.6	1.5	0.0	2.0	1.8	2.3	2.6	2.4	2.1	2.0	2.2	0.7
Triglycerides	3.4	5.6	13.3	2.8	-0.3	2.6	0.4	-0.5	3.4	1.9	3.1	3.3	-0.3	3.6	1.5
Number of incorrect matches in round	3.4	5.6	16.1	1.2	1.8	-3.2	4.0	3.9	-0.1	2.9	0.2	0.1	2.7	-0.3	2.3
Lung cancer (father)	3.4	4.0	7.8	2.7	1.0	1.4	1.0	0.4	2.7	2.1	2.8	2.6	1.6	2.7	0.5
Current tobacco smoking	3.3	5.4	11.1	2.3	2.8	-0.9	2.5	1.8	1.7	2.6	1.8	1.7	3.3	1.7	3.3
Had major operations	3.3	3.9	6.7	1.7	2.5	-0.9	2.6	2.3	1.6	2.6	1.7	1.5	1.3	1.4	2.5
Intelligence (Savage-Jansen 2018)	3.1	9.5	30.5	-2.2	-2.2	3.3	-5.5	-4.6	-0.1	-4.5	-0.5	-0.1	-4.4	-0.0	-0.7
Body Mass Index (BMI) (2010)	3.1	4.2	13.8	0.4	-0.8	3.7	-2.7	-3.3	1.7	-1.3	1.4	1.8	-0.7	1.6	-2.3
Medication: Atenolol	3.1	3.9	8.6	-2.1	-1.3	-1.6	-0.5	0.3	-2.9	-1.8	-2.7	-2.8	-1.4	-2.9	-0.6
Verbal and Numeric Reasoning (VNR)	3.0	7.1	21.1	-1.4	-2.2	3.7	-4.6	-4.2	0.6	-3.5	0.5	0.3	-3.2	0.7	-1.4
Type 2 Diabetes (T2D) (2018)	3.0	5.6	17.4	1.2	0.6	4.2	-2.2	-2.6	2.7	-0.8	2.5	2.5	-2.7	2.8	0.1
Arm fat percentage (right)	3.0	11.8	31.2	-0.9	-1.3	5.6	-5.5	-4.6	1.4	-3.8	0.8	1.4	-4.5	1.3	-3.8
Overall health rating	3.0	6.4	16.0	2.1	0.9	4.0	-1.5	-1.6	3.6	0.2	3.1	3.7	-1.2	3.5	-0.2
Eye problems/disorders: Diabetes related eye disease	2.9	3.2	7.2	2.1	1.1	1.5	0.5	0.4	2.5	1.4	2.6	2.7	-0.1	2.6	1.1
Waist circumference	2.9	10.6	27.8	-0.5	-1.9	5.3	-4.8	-4.0	1.7	-3.2	1.1	1.8	-5.0	1.5	-3.5
Smoking status: Current	2.9	4.6	8.5	2.3	2.6	-0.2	2.0	1.4	2.0	2.3	2.1	1.9	2.8	1.9	2.9
BMI	2.7	15.4	39.8	-1.2	-2.3	6.2	-6.3	-5.9	1.8	-4.3	1.1	1.7	-4.4	1.7	-4.0
Trunk fat percentage	2.7	10.8	27.4	-1.6	-2.3	4.7	-5.2	-4.0	0.6	-4.0	0.0	0.8	-5.1	0.5	-3.7
Arm fat mass (right)	2.7	11.0	28.8	-1.1	-1.6	4.9	-5.4	-4.5	1.1	-3.9	0.4	1.1	-4.4	0.9	-4.2
Exposure to tobacco smoke at home	2.7	3.1	6.1	-2.1	-2.1	0.6	-1.9	-1.6	-1.6	-2.1	-1.5	-1.7	-0.9	-1.6	-2.5
Body fat percentage	2.7	10.7	26.8	-1.3	-2.2	4.9	-5.2	-4.0	0.9	-3.8	0.3	1.0	-4.9	0.8	-3.6
Medication: Ventolin 100micrograms inhaler	2.6	3.3	11.8	0.1	-0.7	2.8	-2.2	-2.6	1.4	-1.1	1.1	1.1	-0.7	1.4	-3.4
Medication: Omeprazole	2.6	3.1	6.1	2.5	0.8	0.5	1.4	1.1	2.1	2.0	2.2	2.2	1.3	2.0	1.7
Pulse rate, automated reading	2.6	8.5	18.7	3.5	0.5	3.6	0.3	-0.5	4.2	2.1	4.2	4.2	0.2	4.3	0.3
Arm fat percentage (left)	2.6	10.5	27.8	-1.0	-1.3	5.3	-5.3	-4.1	1.3	-3.6	0.8	1.4	-4.4	1.2	-3.6
Trunk fat mass	2.5	10.9	28.1	-1.4	-2.0	4.6	-5.3	-4.1	0.8	-4.0	0.1	1.0	-5.0	0.6	-4.0
Whole body fat mass	2.5	10.5	27.0	-1.2	-2.0	4.6	-5.2	-4.2	0.9	-3.8	0.3	1.0	-4.6	0.8	-4.0
Fed-up feelings	2.4	4.4	9.4	1.5	1.3	2.7	-1.3	-1.4	3.1	0.4	2.9	3.0	-0.1	2.9	-1.4
Stomach or abdominal pain in last month	2.4	3.0	7.6	1.8	1.3	2.8	-0.4	-1.2	2.3	0.7	2.3	2.1	0.3	2.2	-0.8
Arm fat mass (left)	2.4	10.0	27.1	-0.9	-1.4	4.8	-5.2	-4.3	1.2	-3.6	0.6	1.2	-4.1	1.1	-3.9
Leg fat mass (left)	2.4	9.3	22.5	-0.6	-1.9	4.7	-4.7	-4.0	1.4	-3.2	0.8	1.5	-4.0	1.3	-3.8
Diabetes (mother)	2.3	3.0	6.4	2.3	-0.4	1.8	-0.2	-0.6	2.5	1.0	2.5	2.4	1.0	2.5	-0.5
Time employed in main current job	2.3	2.7	7.1	1.6	2.4	-1.3	2.3	2.1	0.4	1.9	0.4	0.5	1.1	0.5	2.7
Medication: Cholesterol lowering	2.3	3.5	10.3	1.8	1.5	-1.3	2.7	2.9	0.7	2.4	0.9	1.0	0.8	0.7	3.2
Leg fat mass (right)	2.3	8.9	22.1	-0.7	-1.5	4.7	-4.6	-3.9	1.4	-3.2	0.8	1.5	-4.2	1.2	-3.4
Family relationship satisfaction	2.3	2.9	8.0	-0.1	-1.6	2.8	-2.2	-1.7	1.1	-1.3	0.9	1.1	-2.7	1.2	-1.5
Leg fat percentage (left)	2.3	8.3	22.1	-0.6	-2.0	4.7	-4.3	-3.4	1.3	-2.9	0.8	1.4	-4.1	1.1	-3.4
Ever had hysterectomy (womb removed)	2.2	2.5	5.0	1.5	1.6	1.3	0.3	-0.9	2.2	1.1	2.0	2.0	1.9	2.1	0.0
Townsend deprivation index at recruitment	2.2	3.2	5.7	1.8	1.8	1.3	0.8	-0.1	2.3	1.7	2.4	2.3	1.7	2.4	1.1
Bipolar Disorder or Schizophrenia	2.1	5.1	9.3	-2.2	-2.9	-2.9	-0.3	0.4	-2.9	-1.4	-2.8	-3.0	0.0	-2.8	-1.9
Breast Cancer	2.0	4.7	9.9	-2.3	-1.4	1.7	-3.0	-2.9	-1.8	-3.1	-2.1	-1.8	-1.9	-1.6	-1.7
Wheeze or whistling in the chest in last year	2.0	3.5	11.2	1.0	-1.1	3.4	-2.2	-2.2	1.7	-1.0	1.4	1.6	-2.1	1.8	-1.5
Loneliness, isolation	2.0	2.7	6.6	1.5	-0.2	2.6	-1.2	-0.9	2.4	0.1	2.1	2.3	-0.1	2.4	-0.7
Medication: Omeprazole (e.g. Zanprol)	2.0	2.4	5.8	2.4	0.8	0.9	0.9	0.7	1.9	1.6	1.9	2.0	1.3	1.8	1.0
Body mass index (BMI)	1.9	8.1	21.8	-1.2	-1.4	4.2	-4.7	-3.9	0.7	-3.4	0.2	0.7	-3.8	0.6	-3.3
Fluid intelligence score	1.9	3.9	11.1	-1.9	-1.9	1.6	-3.3	-2.6	-0.6	-2.9	-0.6	-0.7	-2.7	-0.6	-1.1
Leg fat percentage (right)	1.9	6.9	20.2	-0.4	-1.4	4.5	-3.9	-3.1	1.4	-2.5	0.9	1.4	-4.0	1.3	-2.7
Medication for pain relief, constipation, heartburn	1.9	3.3	5.2	-2.1	-1.4	0.1	-1.8	-1.3	-2.2	-2.1	-2.3	-2.3	-1.5	-2.1	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.2	8.4	0.5	0.9	-2.9	2.2	2.0	-0.7	1.4	-0.3	-0.8	1.7	-0.6	1.4
Leg pain on walking	1.9	2.3	6.3	1.4	0.8	1.4	0.2	-0.4	2.3	1.2	2.1	2.5	0.6	2.2	0.7
Qualifications: nursing, teaching	1.9	3.0	6.9	-2.5	-0.3	-0.1	-1.8	-0.6	-2.0	-2.1	-2.0	-1.9	-2.6	-1.8	-0.2
Basal cell carcinoma (self-reported)	1.9	2.2	9.4	1.2	1.0	-1.5	2.1	1.8	0.5	1.7	0.6	0.9	0.8	0.5	3.1
Smoking Status	1.8	4.2	12.1	1.2	2.3	-2.2	2.8	2.2	1.1	2.6	1.2	1.1	1.7	0.9	3.5
Respiratory disease	1.8	3.9	8.2	2.0	-1.0	2.5	-0.5	-1.0	2.9	0.9	2.7	2.7	0.1	2.8	-1.5
Weight	1.8	8.8	23.9	-1.1	-1.4	3.9	-4.9	-4.2	0.8	-3.6	0.1	0.9	-3.8	0.6	-4.0
Falls in the last year	1.8	2.5	8.3	1.2	2.9	-0.8	1.8	1.2	0.9	1.8	1.1	0.7	2.1	0.8	1.8
Eye problems/disorders: None of the above	1.8	2.1	4.5	-1.7	-0.9	-1.1	-0.8	-0.2	-2.0	-1.5	-2.1	-2.0	-1.2	-2.0	-0.1
Chest pain or discomfort	1.8	2.5	5.9	1.4	0.5	2.4	-1.4	-2.0	2.0	-0.3	1.9	2.1	-0.4	1.9	-0.4
Diabetes diagnosed by doctor	1.8	3.0	8.2	0.8	1.5	2.9	-1.7	-1.9	1.8	-0.8	1.5	1.8	-2.2	1.8	1.0
Schizophrenia (2018)	1.7	3.6	8.6	-1.8	-2.3	-2.9	0.2	0.6	-2.4	-0.9	-2.2	-2.5	0.4	-2.4	-1.5
Schizophrenia vs Biploar Disorder	1.7	2.2	6.3	1.3	0.4	-2.0	2.5	1.9	0.7	2.1	1.0	0.8	1.6	0.5	1.1
Maternal smoking around birth	1.7	2.4	5.5	1.9	1.0	1.7	-0.1	-0.7	2.3	0.8	2.3	2.3	0.1	2.1	-0.4
Father’s age at death	1.7	2.2	5.2	-1.5	-2.2	1.4	-2.3	-2.0	-0.5	-2.1	-0.6	-0.5	-1.0	-0.6	-1.4
Age at first live birth	1.7	3.0	6.2	-1.4	-1.9	-2.1	0.7	1.1	-2.5	-0.6	-2.3	-2.3	-0.9	-2.4	-0.9
Suffer from ‘nerves’	1.7	2.6	5.7	2.1	-0.3	2.4	-0.5	-0.5	2.3	0.7	2.1	2.3	-0.1	2.3	-0.4
Fractured/broken bones in last 5 years	1.7	2.2	4.8	2.0	1.5	0.4	1.8	0.4	1.3	1.9	1.3	1.3	2.2	1.2	1.3
Alzheimer’s Disease (including proxy)	1.6	2.3	10.6	-0.8	-1.3	2.2	-1.9	-1.6	0.2	-1.4	0.0	0.3	-3.3	0.2	-0.9
Number of treatments/medications taken	1.6	2.9	4.3	2.1	1.8	0.4	1.6	1.8	1.8	1.9	1.7	2.0	-0.1	1.7	2.0
Ever used hormone-replacement therapy (HRT)	1.6	2.1	3.5	1.8	0.6	0.1	1.6	1.3	1.8	1.9	1.9	1.6	1.0	1.6	0.6
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	3.8	1.7	1.2	0.4	1.1	0.8	1.9	1.5	1.9	1.9	0.5	1.8	0.7
Hip circumference	1.6	7.0	20.0	-1.4	-1.6	3.1	-4.5	-4.0	0.5	-3.3	-0.0	0.6	-3.1	0.5	-3.5
Happiness	1.6	2.0	4.5	-0.2	-1.4	2.0	-2.1	-1.8	0.5	-1.4	0.3	0.6	-1.9	0.5	-2.1
Illnesses of siblings: Diabetes	1.6	1.9	5.9	0.6	-1.3	2.4	-1.9	-2.0	1.0	-1.0	0.8	0.8	-1.6	1.1	-0.8
Friendships satisfaction	1.6	2.0	7.3	-0.8	-2.2	1.5	-1.8	-1.5	0.1	-1.4	-0.2	0.4	-2.7	0.0	-1.3
Schizophrenia (2014)	1.5	3.2	8.4	-1.6	-2.0	-2.9	0.5	0.8	-2.2	-0.5	-2.0	-2.3	0.7	-2.2	-1.6
Hand grip strength (left)	1.5	4.1	6.3	-2.1	-1.7	-1.0	-1.8	-1.6	-2.5	-2.4	-2.5	-2.4	-1.1	-2.4	-2.1
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	6.1	1.4	1.2	0.5	0.5	-0.1	1.6	1.1	1.5	1.5	2.5	1.6	0.3
Mouth/teeth dental problems: Bleeding gums	1.5	2.0	4.8	-1.6	-1.2	0.9	-2.2	-1.9	-0.8	-2.0	-0.8	-0.7	-1.7	-0.6	-1.4
Supplements: Vitamin C	1.5	1.8	4.4	-1.6	0.1	0.0	-2.1	-1.6	-1.3	-2.0	-1.5	-1.3	-1.0	-1.1	-0.2
Osteoporosis (self-reported)	1.5	1.9	7.4	1.3	2.7	-0.9	1.5	0.9	0.5	1.3	0.5	0.7	0.7	0.5	2.4
Medication: Lisinopril	1.5	1.9	4.4	1.8	1.3	0.3	1.5	0.9	1.3	1.7	1.4	1.4	0.2	1.4	2.1
Average weekly spirits intake	1.4	1.7	4.1	-1.6	0.7	-2.0	0.3	0.4	-1.7	-0.6	-1.7	-1.7	0.6	-1.8	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	4.9	1.3	0.0	2.2	-1.2	-1.2	1.8	-0.1	1.4	1.7	-0.9	1.8	-0.8
Pain all over the body in last month	1.4	1.5	3.4	1.7	0.2	0.4	0.6	0.1	1.8	1.3	1.8	1.7	0.4	1.6	0.3
Medication: Metformin	1.3	1.9	4.2	1.5	1.5	2.0	-0.4	-1.1	1.7	0.3	1.8	1.5	-1.0	1.8	0.6
Diabetes (self-reported)	1.3	2.1	5.9	0.7	2.4	1.8	-1.0	-1.3	1.3	-0.4	1.2	1.3	-1.7	1.3	1.8
Birth weight	1.3	2.8	5.5	-2.0	-1.5	0.6	-2.3	-1.9	-0.9	-2.1	-0.9	-1.0	-2.3	-1.0	-2.1
Osteoarthritis (self-reported)	1.3	1.7	5.0	0.4	-1.3	2.2	-1.3	-1.6	1.3	-0.4	1.0	1.2	-0.7	1.4	-1.5
Alzheimer’s Disease (in father)	1.2	1.3	5.5	-0.4	-0.8	2.1	-1.5	-1.2	0.4	-1.1	0.2	0.5	-2.3	0.3	-0.2
Primary Biliary Cirrhosis	1.2	1.8	3.2	1.8	-0.8	0.9	0.8	0.1	1.8	1.4	1.8	1.6	1.6	1.7	-0.3
Severe depression (siblings)	1.2	1.4	5.8	-0.7	-1.4	0.8	-1.7	-1.6	0.1	-1.3	-0.2	-0.0	-0.5	0.1	-2.4
Noisy workplace	1.2	1.5	5.1	0.2	1.4	2.3	-1.7	-1.7	1.0	-0.9	0.8	1.2	-0.7	1.0	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	11.1	-0.4	-2.2	2.9	-3.0	-3.3	0.6	-1.9	0.1	0.6	-0.9	0.6	-2.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	4.4	0.8	0.2	2.1	-1.5	-1.5	1.8	-0.3	1.5	1.8	-0.1	1.7	-1.2
Pulse wave reflection index	1.2	1.4	7.2	-1.3	-1.1	0.6	-1.4	-0.0	-0.9	-1.5	-1.0	-0.4	-2.7	-0.7	0.1
Health satisfaction	1.2	1.6	4.7	0.1	0.1	2.2	-1.7	-1.1	1.3	-0.9	0.8	1.3	-1.7	1.2	-0.8
Ever had bowel cancer screening	1.2	1.4	2.6	1.2	0.9	-0.5	1.6	1.6	1.1	1.6	1.2	1.0	1.5	0.8	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.5	2.6	1.5	0.5	-0.9	1.6	1.5	1.2	1.6	1.4	0.9	1.1	1.1	0.3
Ever taken oral contraceptive pill	1.2	1.3	3.2	-0.3	1.6	1.8	-1.2	-1.7	1.1	-0.5	0.9	1.2	0.2	1.0	0.6
Bipolar Disorder (2018)	1.1	1.7	3.2	-1.3	-1.8	-1.1	-0.7	-0.1	-1.7	-1.0	-1.7	-1.8	-0.5	-1.5	-1.2
Age at First Birth	1.1	1.5	3.8	-1.0	-0.4	-0.9	-0.4	0.3	-1.9	-1.2	-1.9	-1.7	-1.1	-1.8	0.4
Fasting Glucose	1.1	1.3	5.3	-0.5	-0.4	1.7	-1.7	-2.3	0.4	-1.3	0.2	0.3	-1.0	0.3	-1.1
Waist Hip Ratio (WHR)	1.1	4.9	13.4	2.3	-0.3	3.7	0.1	0.9	2.6	1.1	2.5	2.7	-3.4	2.5	0.6
Chronotype (morning person)	1.1	2.6	6.3	1.9	-0.7	2.5	-0.3	-1.1	2.2	0.6	2.1	2.2	0.0	2.2	0.5
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.4	-0.8	-0.5	1.4	-1.7	-1.8	-0.5	-1.5	-0.7	-0.4	0.2	-0.6	-1.6
Asthma	1.1	2.1	4.4	1.2	-0.3	2.0	-1.0	-1.2	2.1	0.1	1.7	2.0	-0.6	2.1	-1.2
Depression (self-reported)	1.1	1.3	2.9	1.6	1.3	1.1	-0.3	-0.7	1.7	0.5	1.5	1.5	0.3	1.6	0.4
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	3.7	-1.7	0.0	-1.6	-0.1	0.4	-1.9	-0.9	-1.7	-1.8	-0.1	-1.9	0.2
Commuting to job workplace: Public transport	1.1	1.4	2.7	-0.7	-1.6	0.9	-1.6	-1.5	-0.6	-1.4	-0.7	-0.5	-1.1	-0.7	-1.6
Pain type(s) experienced in last month: Hip pain	1.1	1.3	2.6	1.6	-0.4	-0.4	1.0	0.5	1.5	1.5	1.6	1.4	-0.1	1.6	0.5
Medication: Paracetamol	1.1	1.7	4.5	1.0	0.5	1.1	0.1	-0.3	2.1	1.0	2.0	2.1	0.2	2.0	-0.7
Alcohol drinker status: Previous	1.1	1.3	2.9	1.4	0.4	0.8	0.5	0.6	1.6	1.0	1.7	1.5	0.3	1.6	0.1
Depressed Affect (Nagel 2018)	1.0	2.0	4.6	1.4	0.2	1.2	-0.2	-0.6	2.2	0.8	2.1	2.1	-0.0	2.0	-1.5
Medication: Levothyroxine sodium	1.0	1.8	3.5	-1.6	-0.6	-1.8	0.4	0.9	-1.8	-0.4	-1.8	-1.7	0.5	-1.9	0.6
High blood pressure (mother)	1.0	1.4	2.5	-1.3	1.0	0.1	-1.0	-1.5	-1.4	-1.6	-1.6	-1.1	-0.0	-1.6	0.2
Had other major operations	1.0	1.2	2.8	-0.8	-1.0	1.1	-1.6	-1.2	-0.5	-1.7	-0.6	-0.5	-1.6	-0.4	-1.1
Medication: Simvastatin	1.0	1.5	9.1	0.6	1.4	-1.1	1.5	1.2	-0.3	1.0	-0.2	0.1	0.8	-0.2	3.0
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	4.6	-2.1	-0.5	-0.3	-1.2	0.0	-1.8	-1.7	-2.0	-1.7	-0.9	-1.8	-0.4
Knee pain experienced in last month	1.0	1.5	4.3	1.3	-0.4	2.1	-0.6	-1.2	1.6	0.1	1.3	1.9	-0.6	1.5	0.2
Hypertension (Self-reported)	1.0	2.7	4.9	2.2	1.9	2.2	0.6	0.4	1.9	1.2	1.8	2.0	-0.2	1.9	1.8
Breast cancer (self-reported)	1.0	1.2	4.3	-0.8	-1.1	-2.1	1.0	0.9	-1.1	0.3	-1.1	-1.2	1.2	-1.0	0.5
Asthma (self-reported)	1.0	2.1	4.5	1.3	-0.0	1.9	-0.8	-1.0	2.1	0.2	1.8	2.0	-0.9	2.1	-0.9
Illnesses of father: None of the above (group 1)	1.0	1.3	3.6	0.9	0.4	-0.4	1.5	1.3	1.0	1.6	1.1	0.6	1.9	1.1	0.5
Myopia	1.0	1.5	3.0	-1.4	-1.0	-0.5	-0.4	-0.3	-1.7	-1.1	-1.6	-1.7	-1.2	-1.7	-0.5
Prostate Cancer	0.9	1.2	7.2	0.8	1.1	-0.0	0.9	-0.4	0.9	1.1	1.0	0.9	2.7	0.8	0.7
Mean Putamen Volume	0.9	1.0	3.5	0.5	1.9	1.3	-0.8	-0.8	1.0	-0.0	1.0	1.0	0.3	1.0	1.0
Blood White Count	0.9	6.6	18.7	-2.0	-1.3	3.9	-4.0	-3.1	0.3	-2.9	0.1	-0.5	-4.3	0.6	-2.3
Heel T-Score	0.9	7.5	17.1	-4.1	-3.4	-2.4	-3.1	-2.9	-1.9	-3.3	-2.0	-1.9	-0.3	-1.9	-3.5
Sensitivity / hurt feelings	0.9	1.6	6.5	-0.0	0.7	-2.5	1.9	1.5	-0.7	1.3	-0.5	-0.7	1.1	-0.7	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.9	1.9	5.5	-0.8	-1.8	0.8	-2.2	-2.4	0.8	-1.5	0.8	0.8	-0.5	0.8	-1.8
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	2.6	1.3	0.6	0.3	0.6	-0.1	1.2	1.1	1.4	0.8	1.6	1.1	0.0
Birth weight of first child	0.9	1.7	5.8	-0.6	-0.8	1.9	-2.1	-1.4	0.4	-1.6	0.1	0.5	-2.4	0.3	-0.6
Gout (self-reported)	0.9	1.2	3.3	-1.3	-1.8	-0.8	-0.0	0.6	-1.3	-0.6	-1.1	-1.3	-0.8	-1.4	-0.8
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.0	1.3	1.4	0.1	0.5	0.5	1.4	1.1	1.4	1.3	0.4	1.3	-0.0
Forced vital capacity (FVC), Best measure	0.9	3.3	9.4	-0.0	-1.8	2.8	-2.7	-3.1	0.8	-1.6	0.3	0.9	-0.8	0.9	-2.5
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.2	1.5	-0.2	0.6	0.8	1.2	1.3	1.2	1.3	1.4	-0.5	1.2	0.2
Leg fat-free mass (right)	0.9	4.9	13.8	-0.5	-0.6	2.8	-3.7	-3.7	0.8	-2.6	0.3	1.0	-1.7	0.8	-3.4
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.6	1.2	0.6	0.4	1.1	1.0	1.1	1.3	1.1	1.0	-0.3	1.2	1.1
Leg predicted mass (right)	0.9	4.8	13.3	-0.5	-0.6	2.7	-3.6	-3.6	0.8	-2.6	0.3	1.0	-1.7	0.8	-3.3
Hearing aid user	0.9	1.1	3.9	-0.4	0.3	-2.0	1.4	1.7	-0.8	0.7	-0.4	-0.9	1.1	-0.8	-0.0
Basal metabolic rate	0.9	5.1	13.3	-0.3	-0.8	2.9	-3.6	-3.5	0.9	-2.5	0.4	1.1	-2.2	0.9	-3.5
Unable to work because of sickness or disability	0.9	1.2	2.2	1.4	1.5	0.2	1.1	0.5	1.1	1.3	1.2	1.0	1.1	1.1	0.7
Lupus	0.8	1.2	3.7	-0.9	1.4	-1.9	0.7	1.6	-0.8	0.2	-0.8	-0.8	-0.4	-1.0	1.1
Neuroticism (2016)	0.8	1.2	3.1	-0.2	-0.5	1.8	-1.6	-1.7	0.5	-1.0	0.5	0.5	-1.6	0.5	-1.0
Cardiovascular Disease	0.8	2.5	6.1	1.7	1.0	2.5	-0.1	-0.2	2.0	0.8	1.9	2.1	-1.5	2.0	1.2
Relative age of first facial hair	0.8	1.6	3.7	0.1	1.7	-1.4	1.8	1.9	-0.0	1.5	0.2	0.0	1.6	-0.1	1.4
Medication: Co-codamol	0.8	0.9	1.9	-0.7	1.2	-1.3	0.8	0.8	-1.3	0.1	-1.2	-1.1	0.4	-1.4	0.4
Leg fat-free mass (left)	0.8	4.1	11.3	-0.2	-0.2	2.7	-3.4	-3.3	1.1	-2.2	0.6	1.1	-1.8	1.0	-2.8
Average weekly fortified wine intake	0.8	1.0	2.8	-1.0	-1.7	-1.4	-0.0	0.4	-1.1	-0.6	-1.0	-1.2	0.8	-1.0	0.1
Leg predicted mass (left)	0.8	4.1	11.3	-0.2	-0.1	2.7	-3.4	-3.3	1.1	-2.2	0.6	1.2	-1.8	1.0	-2.8
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.4	-1.3	-0.6	0.7	-1.3	-0.8	-0.7	-1.3	-0.7	-0.8	-1.5	-0.6	-1.2
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	7.8	-0.1	-1.6	2.7	-2.3	-2.8	0.7	-1.3	0.3	0.7	-0.8	0.8	-2.2
Breastfed as a baby	0.8	1.0	3.2	-1.8	-0.5	-0.6	-0.7	-0.3	-1.1	-1.1	-1.1	-1.0	-1.3	-1.1	-0.4
Peak expiratory flow (PEF)	0.8	1.9	4.6	-1.2	-2.2	0.6	-1.9	-1.9	-0.8	-1.6	-1.0	-0.8	-1.5	-0.7	-1.4
Eye problems/disorders: Cataract	0.8	0.9	2.0	0.8	0.1	1.4	-0.3	-0.1	1.3	0.3	1.3	1.2	-0.2	1.4	-0.9
Back pain experienced in last month	0.8	1.2	2.5	1.6	1.2	-0.0	1.3	1.1	1.1	1.4	1.2	1.0	0.6	1.1	0.1
Mother’s age at death	0.8	1.0	2.9	0.3	1.1	-1.4	1.4	1.2	-0.6	0.8	-0.4	-0.5	0.9	-0.6	1.7
High cholesterol (Self-reported)	0.8	1.5	5.4	0.3	0.1	-1.8	1.6	1.8	-0.9	0.9	-0.8	-0.7	0.0	-0.8	2.3
Reaction Time	0.7	1.2	2.5	1.1	1.6	0.8	0.9	0.2	1.1	1.2	1.1	1.3	1.2	0.9	1.3
Crohns Disease (2012)	0.7	1.1	4.0	0.0	-1.4	1.4	-1.3	-2.0	0.7	-0.8	0.5	0.6	-0.2	0.6	-1.3
Ulcerative Colitis	0.7	1.0	5.1	0.0	-2.3	0.5	-0.3	-0.8	-0.0	-0.3	-0.1	-0.3	1.2	-0.0	-2.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.5	-0.4	-0.6	1.6	-1.3	-1.1	0.5	-1.0	0.3	0.6	-1.4	0.5	-1.2
Supplements: Zinc	0.7	0.8	2.3	0.1	0.4	1.5	-1.5	-1.1	0.2	-1.1	-0.1	0.4	-1.5	0.3	-0.1
Relative age voice broke	0.7	1.0	2.5	-0.5	0.2	-1.6	1.2	1.5	-1.1	0.3	-1.0	-0.9	0.6	-1.2	0.8
Chronic bronchitis/emphysema (father)	0.7	0.8	1.9	1.1	-0.1	0.9	0.1	-0.5	1.3	0.6	1.1	1.4	1.0	1.3	0.1
Past tobacco smoking	0.7	1.2	3.4	-0.6	-0.8	1.1	-1.3	-0.8	-1.1	-1.4	-1.0	-1.2	0.3	-0.8	-1.8
Qualifications: None of the above	0.7	1.5	3.6	1.5	0.1	-0.8	1.9	1.3	0.9	1.8	1.0	0.8	1.8	0.9	-0.0
Mouth/teeth dental problems: Dentures	0.7	1.2	3.9	1.6	0.4	-0.9	1.7	1.1	0.5	1.4	0.6	0.5	2.0	0.4	-0.3
Illnesses of mother	0.7	0.9	1.9	0.9	0.2	-0.6	1.3	1.2	0.7	1.4	0.8	0.9	0.4	0.9	1.3
Pulse wave Arterial Stiffness index	0.7	0.8	6.1	-0.1	0.7	-0.3	0.8	1.0	0.0	0.4	-0.0	0.5	-0.7	0.1	2.5
Medication: Paracetamol	0.7	1.1	2.8	0.7	0.7	0.5	0.3	-0.1	1.6	1.0	1.5	1.7	1.0	1.5	-0.3
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	5.5	-1.1	-1.3	0.3	-1.4	-1.5	-0.3	-1.2	-0.3	-0.7	-0.2	-0.2	-2.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	3.5	0.8	0.9	-0.6	1.2	1.9	0.7	1.3	0.9	0.7	-0.2	0.6	0.6
Pulse wave peak to peak time	0.7	0.8	6.2	0.1	-0.7	0.4	-0.9	-1.2	0.1	-0.5	0.1	-0.3	0.7	0.1	-2.5
Age at last live birth	0.7	1.0	2.8	-0.7	-1.7	-0.4	0.0	-0.1	-1.2	-0.5	-0.9	-1.0	-1.0	-1.0	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	4.2	0.5	0.1	2.1	-1.1	-0.8	0.7	-0.5	0.6	0.9	-0.2	0.8	-0.5
Wears glasses or contact lenses	0.7	0.8	2.7	-0.4	-1.0	1.0	-1.4	-1.0	-0.1	-1.2	-0.2	-0.1	-1.6	-0.1	-0.7
Financial situation satisfaction	0.7	0.8	2.7	1.1	-1.6	-0.1	0.3	0.6	1.1	0.6	1.1	1.2	0.1	1.1	-0.4
Arm fat-free mass (left)	0.7	3.6	10.1	0.1	-0.9	2.5	-2.9	-2.9	1.1	-1.8	0.5	1.2	-1.7	1.0	-3.2
Supplements: Calcium	0.7	0.8	4.0	-0.1	2.0	-0.3	0.7	0.7	-0.4	0.2	-0.5	-0.0	0.1	-0.5	1.9
Arm predicted mass (left)	0.7	3.5	8.8	0.1	-0.9	2.5	-2.8	-2.8	1.0	-1.8	0.5	1.1	-1.9	0.9	-3.0
Depression (Nagel 2018)	0.6	0.9	2.6	0.8	-0.6	0.7	-0.4	-0.4	1.3	0.3	1.3	1.0	-0.5	1.3	-1.6
Worry (Nagel 2018)	0.6	1.2	3.2	1.8	0.9	0.1	0.8	1.1	1.3	1.2	1.2	1.3	-0.4	1.3	0.7
HbA1C	0.6	0.7	5.6	-0.3	-2.4	-0.2	-0.6	-0.2	-0.6	-0.3	-0.5	-0.4	-0.3	-0.5	-1.0
Hand grip strength (right)	0.6	1.7	3.6	-1.1	-1.4	0.2	-1.7	-1.4	-1.1	-1.7	-1.3	-0.9	-1.1	-1.0	-1.9
Taking other prescription medications	0.6	0.9	1.7	1.3	0.8	0.6	0.7	1.3	1.1	0.9	1.0	1.3	0.0	1.0	0.3
Had menopause	0.6	0.7	1.7	1.1	0.3	0.2	1.1	1.3	0.9	1.0	0.9	0.8	-0.0	0.8	0.5
Neuroticism score	0.6	1.2	2.6	1.2	0.8	0.5	0.4	0.6	1.6	1.1	1.6	1.5	-0.2	1.6	0.1
Length of working week for main job	0.6	0.6	2.3	-0.2	0.9	-1.5	1.0	1.2	-0.4	0.6	-0.0	-0.5	0.8	-0.6	0.8
Headache pain in last month	0.6	1.0	4.1	-0.3	-0.3	1.6	-1.4	-1.2	0.4	-0.9	0.4	0.4	0.6	0.4	-2.0
Exposure to tobacco smoke outside home	0.6	0.9	4.0	0.4	1.2	-1.0	0.9	0.7	0.3	1.0	0.5	0.4	2.0	0.2	1.0
Mean time to correctly identify matches	0.6	1.2	3.0	1.0	1.7	0.6	1.1	0.7	0.8	1.1	0.8	1.0	1.2	0.6	1.7
Number of full sisters	0.6	0.7	2.9	0.2	-0.6	1.2	-1.2	-1.7	0.5	-0.7	0.2	0.5	-0.9	0.5	-0.0
Smoking status: Previous	0.6	1.0	3.0	0.6	0.3	-1.7	1.5	1.0	0.7	1.4	0.7	0.8	-0.1	0.5	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.4	1.5	-1.2	0.7	-0.4	-0.7	1.4	0.4	1.2	1.5	0.7	1.4	-1.4
Whole body fat-free mass	0.6	3.3	9.4	-0.2	-0.6	2.1	-2.9	-2.9	0.7	-2.0	0.2	0.8	-1.5	0.6	-3.1
Long-standing illness, disability or infirmity	0.6	0.9	2.2	1.4	0.2	1.1	0.1	-0.1	1.4	0.7	1.2	1.4	-0.4	1.5	0.0
Whole body water mass	0.6	3.3	9.7	-0.1	-0.5	2.2	-2.9	-2.9	0.8	-1.9	0.3	0.9	-1.5	0.8	-3.1
Illnesses of father: High blood pressure	0.6	0.7	1.5	-0.9	1.2	0.1	-0.6	-0.5	-0.9	-0.7	-1.0	-0.8	-0.8	-1.0	0.9
Ever smoked	0.6	1.0	6.1	0.5	1.2	-0.7	0.9	0.5	0.8	1.0	0.7	0.9	-0.2	0.7	2.5
Blood Eosinophil Count	0.5	4.1	16.7	-0.7	-0.1	4.1	-2.9	-2.9	1.4	-1.8	1.1	1.3	-2.0	1.5	-0.3
Hypothyroidism (self reported)	0.5	1.2	3.4	-1.9	-0.6	-0.1	-1.1	0.2	-1.3	-1.3	-1.3	-1.3	-1.2	-1.2	-0.2
Qualifications: CSEs or equivalent	0.5	0.6	1.5	0.6	0.2	0.4	0.7	0.2	0.9	1.2	1.0	0.8	1.2	0.8	-0.2
Hearing difficulty/problems with background noise	0.5	0.9	4.4	0.5	1.1	-1.3	1.1	0.3	0.3	0.9	0.4	0.3	2.1	0.2	0.4
Hair/balding pattern: Pattern 2	0.5	0.7	2.8	0.2	-1.4	0.9	-0.7	-1.3	0.4	-0.3	0.1	0.5	0.3	0.3	-1.7
Forced vital capacity (FVC)	0.5	1.8	6.2	0.2	-0.8	2.2	-1.9	-2.5	0.8	-0.9	0.5	0.8	-0.5	0.8	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	3.9	-0.4	-1.2	0.4	-1.6	-2.0	0.9	-1.0	0.8	0.8	0.3	0.8	-1.2
Heart attack	0.5	0.6	2.6	0.1	0.5	-0.8	0.9	1.0	-0.4	0.5	-0.3	-0.3	-1.0	-0.2	1.6
Medication: Ramipril	0.5	0.6	1.9	0.5	1.3	1.3	-0.4	0.5	0.2	-0.1	-0.0	0.5	-1.2	0.3	1.4
Prospective memory result	0.5	0.7	2.0	0.5	0.7	-0.9	1.3	1.3	-0.0	1.0	0.0	-0.2	1.4	-0.0	0.1
High blood pressure (siblings)	0.5	0.8	1.7	-1.0	-0.8	-0.9	-0.3	-0.2	-1.1	-0.6	-1.1	-1.3	-0.6	-1.1	-0.7
Worry too long after embarrassment	0.5	0.9	5.2	-0.2	-1.7	0.0	-0.9	-1.0	0.3	-0.6	0.4	0.1	-0.6	0.4	-2.3
Mouth/teeth dental problems: Loose teeth	0.5	0.5	2.2	0.4	0.8	1.2	-0.1	0.3	0.7	0.0	0.7	0.7	-1.5	0.7	0.2
Handedness (chirality/laterality): Left-handed	0.5	0.6	3.1	-0.9	-0.6	0.2	-0.6	0.0	-0.7	-0.8	-0.7	-0.7	-1.8	-0.7	-0.1
Number of self-reported non-cancer illnesses	0.5	0.8	2.1	1.4	0.8	1.4	0.2	0.7	1.0	0.5	0.9	1.1	-0.5	1.0	0.5
Guilty feelings	0.5	0.7	1.4	1.0	0.9	0.5	0.4	0.1	1.2	0.9	1.2	1.1	0.6	1.1	-0.1
Irritability	0.5	0.8	2.5	-0.6	0.1	-1.6	0.5	0.9	-1.2	-0.2	-1.2	-1.0	-0.2	-1.2	0.0
Ever had prostate specific antigen (PSA) test	0.5	0.5	2.0	-0.7	-0.4	-1.4	0.7	0.4	-0.8	0.0	-0.7	-0.6	-0.3	-1.0	0.8
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.9	0.8	1.4	-0.8	0.9	1.2	-0.2	0.6	0.0	-0.4	1.0	-0.1	0.5
Heart disease (siblings)	0.5	0.7	2.5	0.5	-0.1	1.5	-0.9	-0.8	0.6	-0.3	0.4	0.8	-1.6	0.6	-0.1
Alzheimer’s Disease (in mother)	0.4	0.5	2.8	0.1	-0.7	1.1	-0.2	0.2	0.5	0.0	0.5	0.6	-1.7	0.6	-0.3
Major Depression (MDD)	0.4	0.5	1.0	0.5	0.4	0.9	-0.5	-0.1	0.9	0.1	0.9	1.0	-1.0	0.8	-0.4
Ovarian Cancer	0.4	0.6	1.6	1.2	0.8	0.4	0.7	0.0	0.6	0.7	0.7	0.7	1.2	0.6	0.7
Lung FEV1/FVC ratio	0.4	2.2	4.2	-1.5	-1.1	2.0	-2.0	-1.6	-0.8	-2.0	-1.1	-0.9	-1.7	-0.8	-1.6
Hearing difficulty/problems: Yes	0.4	0.6	1.7	0.2	0.4	0.5	-0.7	-1.3	0.9	-0.3	0.9	0.8	-0.0	0.8	-0.9
Impedance of leg (right)	0.4	1.8	5.0	1.3	-0.1	-0.5	2.2	2.1	0.6	2.1	0.7	0.7	0.5	0.7	2.0
Serious illness, injury or assault to yourself	0.4	0.5	2.7	-0.3	1.6	-0.5	0.5	0.4	-0.4	0.2	-0.4	-0.4	0.8	-0.3	0.9
Allergy	0.4	0.9	2.1	-1.1	-0.6	-0.9	-0.3	-0.2	-1.4	-0.7	-1.3	-1.3	0.5	-1.4	-0.2
Illnesses of siblings	0.4	0.5	1.8	0.7	0.1	-0.6	0.9	1.1	0.4	0.9	0.5	0.4	1.4	0.4	0.3
Trunk fat-free mass	0.4	2.3	8.1	0.0	-0.4	1.6	-2.4	-2.5	0.5	-1.7	0.1	0.6	-1.2	0.5	-2.8
Trunk predicted mass	0.4	2.2	7.8	0.1	-0.5	1.5	-2.3	-2.4	0.5	-1.6	0.1	0.6	-1.1	0.5	-2.8
Hair/balding pattern: Pattern 4	0.4	1.1	2.8	1.2	1.6	1.7	-0.4	-0.4	1.2	0.2	1.2	1.2	-0.1	1.2	0.1
Arm fat-free mass (right)	0.4	2.2	7.1	0.0	-0.7	1.7	-2.2	-2.1	0.7	-1.5	0.3	0.9	-1.4	0.7	-2.7
Number of full brothers	0.4	0.5	2.2	-0.1	1.1	0.8	-0.8	-1.5	0.3	-0.4	0.0	0.4	-0.3	0.4	1.0
Emphysema/chronic bronchitis	0.4	0.4	1.4	-0.0	0.1	1.0	-0.5	-1.2	0.5	-0.3	0.5	0.4	0.8	0.3	-1.1
Medication: Blood pressure	0.4	0.7	4.5	0.8	0.7	-0.1	1.0	1.0	0.1	0.8	0.2	0.5	0.0	0.0	2.1
Medication: Ibuprofen	0.4	0.5	1.4	0.5	0.1	0.1	0.7	0.3	1.0	0.8	1.2	1.0	-0.0	1.1	0.2
Medication: Seretide 50 evohaler	0.4	0.4	2.4	0.2	-0.8	-1.0	0.8	0.4	-0.1	0.6	-0.1	-0.2	0.3	-0.1	-1.5
Arm predicted mass (right)	0.4	2.3	7.8	-0.1	-0.8	1.7	-2.3	-2.3	0.7	-1.5	0.2	0.8	-1.3	0.6	-2.8
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.7	-0.4	-1.3	-0.7	0.8	0.9	-0.7	0.3	-0.5	-0.7	-0.9	-0.7	-0.5
Mood swings	0.4	0.7	1.6	0.7	1.0	-0.2	0.6	0.2	1.0	0.8	1.1	1.0	1.2	0.9	-0.4
Commuting to job workplace: Walk	0.4	0.5	2.3	0.5	0.8	-0.9	0.7	0.3	0.1	0.5	-0.1	0.4	0.5	0.1	1.5
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.8	0.8	0.0	-0.7	0.8	0.8	0.6	0.9	0.5	0.7	0.5	0.6	-0.0
Average weekly beer plus cider intake	0.4	0.6	1.2	0.8	-0.6	0.9	-0.2	-1.1	0.9	0.4	0.9	0.8	0.6	1.0	-0.4
Diastolic blood pressure, automated reading	0.4	1.2	6.2	1.0	-0.0	2.5	-0.4	-0.4	1.3	0.3	1.2	1.1	-0.0	1.4	0.1
Neuroticism (Nagel 2018)	0.3	0.7	1.4	1.0	-0.0	-0.2	0.5	0.3	1.0	0.8	1.1	1.0	-0.3	1.0	-1.2
Crohns Disease (2017)	0.3	0.6	1.8	-0.8	-0.6	0.8	-1.3	-1.3	-0.1	-1.1	-0.1	-0.2	-0.6	-0.1	-0.9
Ulcerative Colitis (UC)	0.3	0.5	1.7	0.9	-0.8	0.6	0.6	-0.1	0.6	0.6	0.6	0.4	1.3	0.6	-0.7
Bipolar Disorder (2011)	0.3	0.3	1.1	-0.2	-1.0	-0.6	0.0	0.2	-0.5	-0.1	-0.4	-0.7	0.2	-0.5	-0.7
Coronary Artery Disease (CAD)	0.3	0.3	1.1	-0.1	0.3	-0.1	0.2	0.9	-0.5	0.1	-0.7	0.1	-0.8	-0.5	-1.0
Allergy or Eczema	0.3	0.9	1.6	1.0	0.9	0.2	0.9	1.1	1.1	1.2	1.2	0.8	-0.1	1.3	0.5
Tanning	0.3	4.1	8.4	2.0	0.8	-1.0	2.7	2.7	1.9	2.9	2.0	2.0	1.8	1.9	1.8
Angina	0.3	0.4	1.3	0.3	0.2	-0.5	1.1	1.2	-0.5	0.5	-0.3	-0.4	-0.3	-0.5	0.7
Age when periods started (menarche)	0.3	0.8	2.0	0.9	0.9	-0.1	1.2	0.1	0.8	1.2	0.9	1.0	1.4	0.8	0.3
High blood pressure	0.3	1.0	3.0	1.3	1.2	1.7	0.0	0.1	1.0	0.4	0.9	1.1	-0.5	1.0	0.9
Supplements: Glucosamine	0.3	0.4	0.8	-0.8	0.4	0.6	-0.8	-0.6	-0.4	-0.9	-0.6	-0.2	-0.9	-0.5	-0.2
Sitting height	0.3	1.9	9.9	0.5	-0.4	-3.1	1.9	1.9	-0.4	1.3	-0.5	-0.4	1.3	-0.4	-0.9
Nervous feelings	0.3	0.6	1.9	0.7	1.4	-0.3	0.7	0.9	0.7	0.9	0.7	0.7	0.3	0.6	0.4
Migraine (self-reported)	0.3	0.3	0.8	-0.9	-0.7	-0.9	-0.2	-0.5	-0.3	-0.4	-0.3	-0.6	0.5	-0.4	-0.6
Heart disease (mother)	0.3	0.4	1.8	-0.8	-0.1	-0.4	-0.5	-0.0	-0.6	-0.6	-0.6	-0.6	0.2	-0.8	-1.3
Illnesses of father: Heart disease	0.3	0.5	2.2	-0.5	-0.4	-1.0	-0.0	0.2	-0.8	-0.3	-0.7	-0.5	-1.5	-0.8	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.7	0.4	0.1	-0.8	1.1	1.3	-0.2	0.7	-0.1	-0.2	-0.3	-0.3	-0.6
Eye problems/disorders: Glaucoma	0.3	0.4	1.8	-0.1	-0.0	-1.0	1.0	0.3	-0.3	0.7	-0.1	-0.2	1.3	-0.4	-0.4
Medication: Blood pressure	0.3	0.6	2.4	-0.1	0.4	1.6	-1.0	-0.8	0.1	-0.9	-0.1	0.0	-1.4	0.1	0.0
Supplements: Fish oil (including cod liver oil)	0.3	0.3	1.1	1.1	0.8	-0.1	0.6	0.9	0.2	0.7	0.1	0.1	0.1	0.2	0.7
Medication: Bendroflumethiazide	0.3	0.4	2.8	0.6	0.5	0.3	0.3	0.7	0.3	0.3	0.0	0.6	-0.4	0.2	1.7
Medication: Atorvastatin	0.3	0.3	0.9	0.7	0.4	0.3	0.8	0.9	0.3	0.7	0.3	0.5	-0.6	0.2	0.6
Number of operations (self-reported)	0.3	0.4	1.8	-0.3	1.1	0.5	-0.4	0.1	0.4	-0.3	0.2	0.4	-1.4	0.3	1.0
Risk taking	0.3	0.4	1.2	-0.1	1.1	-1.0	0.6	0.7	-0.3	0.4	-0.2	-0.2	0.4	-0.2	1.0
Ever depressed for a whole week	0.3	0.4	0.8	0.4	-0.5	-0.0	0.2	0.7	0.9	0.5	0.9	0.9	-0.7	0.8	-0.3
Vascular/heart problems diagnosed by doctor	0.3	0.9	3.3	-1.3	-0.7	-1.8	0.1	0.1	-0.9	-0.2	-0.8	-1.1	0.7	-0.9	-0.8
Cholesterol lowering medication	0.3	0.4	1.8	-0.1	-0.1	-0.8	0.5	-0.0	-0.7	0.1	-0.7	-0.5	0.5	-0.7	1.3
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.6	-0.1	0.5	-0.6	0.7	0.8	-0.5	0.3	-0.5	-0.4	-0.9	-0.4	1.3
Irritable Bowel Disease (IBD)	0.2	0.4	1.2	-0.3	-1.0	0.9	-0.7	-1.0	0.1	-0.7	0.0	-0.1	0.3	0.0	-1.1
HDL Cholesterol	0.2	0.3	2.1	0.1	1.5	0.7	-0.2	-0.6	0.1	-0.2	0.3	0.2	0.4	0.1	0.7
Rheumatoid Arthritis	0.2	0.3	0.8	0.1	0.9	-0.4	0.5	0.4	-0.5	0.3	-0.5	-0.4	0.7	-0.6	0.4
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.6	0.8	0.2	0.6	0.0	-0.2	0.7	0.1	0.8	0.4	-0.6	0.6	-0.3
Blood Red Count	0.2	1.8	4.1	0.8	2.0	2.0	0.1	0.3	1.5	0.8	1.5	1.6	-0.5	1.6	1.5
Systolic Blood Pressure	0.2	1.1	5.6	1.2	0.5	2.4	-0.9	-0.7	0.9	-0.2	0.8	0.8	-1.1	1.1	0.1
Lung FVC	0.2	0.9	4.5	0.3	0.2	2.1	-0.9	-1.5	0.9	-0.1	0.8	0.9	-0.1	0.8	0.4
Neuroticism	0.2	0.5	1.1	0.8	-0.3	0.5	-0.1	0.2	0.9	0.3	0.9	0.7	-1.1	0.9	-0.7
Medication for hormone replacement therapy	0.2	0.2	0.8	0.2	-0.9	-0.0	-0.1	-0.1	0.5	0.2	0.5	0.1	0.6	0.5	-0.3
Vitamin and mineral supplements	0.2	0.3	0.8	-0.2	-0.3	-0.1	0.7	0.9	0.4	0.7	0.5	0.2	-0.9	0.4	0.5
Diabetes (father)	0.2	0.3	1.1	0.0	-0.2	1.0	-1.1	-0.3	0.0	-0.8	-0.2	-0.2	-0.8	-0.0	-0.1
Multivitamins +/- minerals	0.2	0.3	1.6	0.4	0.4	-0.5	0.1	-0.1	-0.6	-0.2	-0.7	-0.4	1.3	-0.6	-0.0
Impedance of leg (left)	0.2	0.9	2.6	0.9	-1.2	-0.4	1.6	1.5	0.3	1.5	0.4	0.4	0.4	0.3	0.9
Alcohol usually taken with meals	0.2	0.4	1.8	-0.4	-1.3	0.1	-0.4	-0.4	-0.6	-0.6	-0.8	-0.7	-0.0	-0.6	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.1	0.2	0.4	0.5	-1.1	-0.9	0.4	-0.7	0.1	0.3	0.2	0.3	-0.3
Financial difficulties in last 2 years	0.2	0.2	1.1	-0.4	0.3	-0.9	-0.3	-0.1	-0.2	-0.3	-0.2	-0.0	0.1	-0.3	1.1
Mouth/teeth dental problems	0.2	0.3	1.9	0.3	0.1	0.4	0.0	0.1	0.7	0.5	0.6	0.6	0.1	0.7	1.4
Alcohol intake versus 10 years previously	0.2	0.4	1.1	-0.9	-0.2	-0.1	-0.2	-0.1	-0.7	-0.5	-0.6	-0.8	-0.1	-0.8	-1.1
Number of live births	0.2	0.3	0.8	0.9	0.9	-0.3	0.9	0.8	0.2	0.7	0.3	0.2	-0.1	0.2	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.6	-0.2	0.1	-0.7	0.8	0.8	-0.1	0.4	0.0	-0.2	0.3	-0.1	0.6
Medication: Lansoprazole	0.2	0.2	0.6	0.8	0.5	-0.3	0.5	0.6	0.2	0.6	0.1	0.2	0.3	0.2	0.2
Ever highly irritable/argumentative for 2 days	0.2	0.2	1.1	-0.7	-0.3	-1.0	-0.1	-0.1	-0.5	-0.3	-0.6	-0.4	-0.0	-0.6	-0.2
Blood clot in the leg (DVT)	0.2	0.3	1.1	0.4	1.1	-0.6	0.4	0.7	-0.3	0.2	-0.1	-0.5	0.6	-0.2	0.3
Glaucoma (self-reported)	0.2	0.3	0.5	0.5	0.7	0.1	0.6	0.1	0.6	0.7	0.6	0.7	0.4	0.5	0.3
Medication: Amlodipine	0.2	0.3	1.4	0.4	0.7	1.2	-0.1	-0.4	0.4	0.1	0.2	0.7	0.6	0.3	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	1.0	0.0	0.2	-0.6	0.8	-0.2	-0.2	0.6	-0.2	0.1	0.6	-0.3	1.0
Shortness of breath walking on level ground	0.2	0.2	0.7	-0.8	0.6	0.0	-0.4	-0.3	-0.1	-0.5	-0.4	0.1	-0.8	-0.3	0.3
Angina (self-reported)	0.2	0.3	0.9	0.4	0.2	-0.2	1.0	0.9	-0.4	0.4	-0.2	-0.3	-0.3	-0.4	0.6
Medication: Allopurinol	0.2	0.2	1.1	0.0	-1.0	-0.5	0.5	0.9	-0.3	0.3	-0.2	-0.3	-0.1	-0.3	0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.3	1.2	-0.7	-0.7	-0.0	-0.4	-0.2	-0.1	-0.4	-0.1	-0.0	-1.1	-0.1	-0.7
Medication: Aspirin	0.2	0.3	1.1	0.5	-0.4	-0.7	0.9	0.8	-0.1	0.5	-0.1	0.1	0.2	-0.1	1.0
Average weekly red wine intake	0.2	0.3	1.4	0.7	0.6	-0.0	0.4	1.1	-0.1	0.2	-0.1	0.2	-0.6	-0.1	1.2
Medication for cholesterol	0.2	0.3	2.0	-0.2	-0.7	-0.4	-0.1	-0.3	-0.3	-0.2	-0.3	-0.2	0.3	-0.3	-1.4
Mineral and other dietary supplements	0.2	0.2	0.7	0.0	-0.8	0.1	0.1	-0.2	0.6	0.3	0.7	0.6	0.5	0.7	-0.5
Medication: Aspirin	0.2	0.2	1.3	0.3	0.0	-0.4	0.6	0.5	-0.4	0.1	-0.4	-0.0	-0.2	-0.4	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.3	-0.3	-1.0	1.0	-1.0	-1.2	-0.2	-0.7	-0.4	-0.2	-0.4	-0.1	-0.5
Average weekly champagne plus white wine intake	0.2	0.2	0.7	0.2	0.3	0.9	-0.8	-0.7	0.1	-0.6	-0.1	0.1	-0.4	0.2	0.3
Miserableness	0.2	0.3	0.6	0.5	0.4	0.0	0.5	0.4	0.6	0.7	0.8	0.7	0.4	0.5	-0.8
Alcohol drinker status: Never	0.2	0.2	0.7	-0.4	-0.4	0.8	-0.5	-0.4	0.2	-0.4	0.1	0.3	-0.7	0.0	0.5
Age started oral contraceptive pill	0.2	0.2	1.6	-0.1	0.3	-0.4	0.6	0.4	-0.3	0.3	-0.3	-0.3	1.2	-0.3	0.3
Commuting to job workplace: Cycle	0.2	0.2	0.5	0.7	-0.1	0.2	0.4	-0.7	0.5	0.5	0.4	0.6	-0.1	0.5	-0.1
Impedance of whole body	0.2	0.9	3.0	0.5	-0.0	-0.8	1.6	1.6	0.1	1.3	0.2	0.3	0.5	0.1	1.7
LDL Cholesterol	0.1	0.1	0.5	0.5	-0.7	0.2	-0.1	-0.2	0.2	-0.0	0.2	0.3	0.5	0.3	0.3
Blood Platelet Count	0.1	1.4	4.8	-0.2	-1.1	1.0	-1.2	-2.2	1.1	-0.5	1.0	1.3	-0.9	1.1	-1.6
Frequency of depressed mood in last 2 weeks	0.1	0.2	1.1	-0.2	-0.1	0.1	-0.8	-0.5	0.0	-0.6	-0.2	0.1	0.1	-0.2	-1.1
Systolic blood pressure, automated reading	0.1	0.3	1.3	1.0	-0.3	1.2	-0.2	0.3	0.4	0.2	0.5	0.2	-0.6	0.6	-0.0
Pack years adult smoking proportion	0.1	0.1	0.7	-0.1	-0.8	-0.1	-0.2	0.3	-0.1	-0.1	-0.3	-0.0	-0.0	-0.1	-0.4
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.5	-0.0	0.4	0.5	-0.1	0.3	0.4	-0.0	0.4	0.2	-0.7	0.5	0.2
Worrier / anxious feelings	0.1	0.2	1.0	0.1	0.3	-0.2	-0.1	0.5	-0.3	-0.1	-0.3	-0.3	-1.0	-0.1	0.4
Hair/balding pattern: Pattern 3	0.1	0.2	0.6	0.3	0.2	0.1	0.3	-0.1	0.7	0.5	0.8	0.6	0.2	0.7	0.4
Impedance of arm (left)	0.1	0.3	1.6	-0.1	0.6	-0.5	0.7	1.0	-0.1	0.6	0.0	0.1	0.2	-0.1	1.3
Standing height	0.1	0.6	3.6	0.1	-0.2	-0.1	-1.0	-0.9	0.1	-0.8	-0.4	0.5	-0.8	0.1	-1.9
Tense / ‘highly strung’	0.1	0.2	0.8	0.6	0.6	-0.0	0.5	0.9	-0.0	0.4	-0.2	0.1	-0.4	-0.1	0.8
Loud music exposure frequency	0.1	0.1	0.3	-0.1	0.3	0.3	0.1	0.3	0.4	0.1	0.5	0.6	-0.3	0.3	0.3
Pack years of smoking	0.1	0.1	0.5	0.2	-0.7	0.0	0.1	0.6	0.1	0.1	-0.1	0.1	-0.1	0.1	-0.4
Height	0.0	0.4	1.4	0.1	0.2	-1.1	-0.4	-0.3	-0.4	-0.7	-0.7	0.2	-1.0	-0.4	-1.2
Hair Pigment	0.0	0.8	2.9	0.7	1.2	-1.1	0.8	0.4	0.7	1.0	0.7	0.7	1.7	0.6	0.1
Impedance of arm (right)	0.0	0.1	0.7	-0.0	0.3	0.2	0.2	0.2	0.1	0.1	0.1	0.2	-0.3	0.1	0.8
Alcohol intake frequency.	0.0	0.1	0.3	-0.3	0.6	0.6	-0.4	-0.4	0.0	-0.3	0.1	-0.0	-0.1	-0.1	0.5
Comparative height size at age 10	0.0	0.1	1.0	0.2	1.0	-0.2	-0.2	-0.6	0.1	-0.2	-0.0	0.2	0.0	0.1	0.0

Hub : Genes

DMXL2

Models

Trait associations