Hub : Genes

DMXL2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.053	0.0230	0.00450	0.041	0.004	0.017	0.008	0.012	7.9e-06	0.088	2.9e-03	0.03	9.9e-03
2	GTEx	Artery Tibial	0.087	0.0372	0.00370	0.102	NA	0.075	NA	0.093	2.2e-08	NA	1.7e-06	NA	9.0e-08
3	GTEx	Cells EBV-transformed lymphocytes	0.167	0.0760	0.00043	0.130	NA	0.013	NA	0.063	5.2e-05	NA	1.1e-01	NA	4.2e-03
4	GTEx	Cells Transformed fibroblasts	0.063	0.0300	0.00940	0.058	NA	0.054	NA	0.055	3.7e-05	NA	7.1e-05	NA	5.9e-05
5	GTEx	Esophagus Mucosa	0.094	0.0440	0.00390	0.012	NA	0.002	NA	0.004	4.9e-02	NA	2.3e-01	NA	1.7e-01
6	GTEx	Esophagus Muscularis	0.130	0.0470	0.00055	0.075	NA	0.076	NA	0.073	2.6e-05	NA	2.2e-05	NA	3.4e-05
7	GTEx	Muscle Skeletal	0.125	0.0425	0.00011	0.043	NA	0.021	NA	0.032	4.6e-05	NA	3.7e-03	NA	3.8e-04
8	GTEx	Nerve Tibial	0.343	0.0578	0.00000	0.301	NA	0.306	NA	0.308	1.3e-21	NA	4.5e-22	NA	3.0e-22
9	GTEx	Pituitary	0.236	0.0890	0.00240	0.193	NA	0.133	NA	0.146	1.4e-05	NA	3.3e-04	NA	1.7e-04
10	TCGA	Kidney Renal Papillary Cell Carcinoma	0.174	0.1070	0.00540	0.009	0.023	0.029	NA	0.024	9.5e-02	0.017	9.0e-03	NA	1.4e-02
11	TCGA	Pheochromocytoma and Paraganglioma	0.121	0.0760	0.00320	0.047	0.032	0.059	NA	0.056	5.8e-03	0.020	2.2e-03	NA	2.8e-03
12	TCGA	Uterine Corpus Endometrial Carcinoma	0.416	0.1850	0.00980	-0.006	0.025	0.039	NA	0.017	5.0e-01	0.067	3.0e-02	NA	1.0e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	1.1	1.7	3.2	-1.3	-1.8	-1.1	-0.7	-0.1	-1.7	-1.0	-1.7	-1.8	-0.5	-1.5	-1.2
Bipolar Disorder or Schizophrenia	2.1	5.1	9.3	-2.2	-2.9	-2.9	-0.3	0.4	-2.9	-1.4	-2.8	-3.0	0.0	-2.8	-1.9
Depressed Affect (Nagel 2018)	1.0	2.0	4.6	1.4	0.2	1.2	-0.2	-0.6	2.2	0.8	2.1	2.1	-0.0	2.0	-1.5
Depression (Nagel 2018)	0.6	0.9	2.6	0.8	-0.6	0.7	-0.4	-0.4	1.3	0.3	1.3	1.0	-0.5	1.3	-1.6
Intelligence (Savage-Jansen 2018)	3.1	9.5	30.5	-2.2	-2.2	3.3	-5.5	-4.6	-0.1	-4.5	-0.5	-0.1	-4.4	-0.0	-0.7
Neuroticism (Nagel 2018)	0.3	0.7	1.4	1.0	-0.0	-0.2	0.5	0.3	1.0	0.8	1.1	1.0	-0.3	1.0	-1.2
Schizophrenia (2018)	1.7	3.6	8.6	-1.8	-2.3	-2.9	0.2	0.6	-2.4	-0.9	-2.2	-2.5	0.4	-2.4	-1.5
Schizophrenia vs Biploar Disorder	1.7	2.2	6.3	1.3	0.4	-2.0	2.5	1.9	0.7	2.1	1.0	0.8	1.6	0.5	1.1
Worry (Nagel 2018)	0.6	1.2	3.2	1.8	0.9	0.1	0.8	1.1	1.3	1.2	1.2	1.3	-0.4	1.3	0.7
Alzheimer’s Disease (in mother)	0.4	0.5	2.8	0.1	-0.7	1.1	-0.2	0.2	0.5	0.0	0.5	0.6	-1.7	0.6	-0.3
Alzheimer’s Disease (in father)	1.2	1.3	5.5	-0.4	-0.8	2.1	-1.5	-1.2	0.4	-1.1	0.2	0.5	-2.3	0.3	-0.2
Alzheimer’s Disease (including proxy)	1.6	2.3	10.6	-0.8	-1.3	2.2	-1.9	-1.6	0.2	-1.4	0.0	0.3	-3.3	0.2	-0.9
Crohns Disease (2017)	0.3	0.6	1.8	-0.8	-0.6	0.8	-1.3	-1.3	-0.1	-1.1	-0.1	-0.2	-0.6	-0.1	-0.9
Irritable Bowel Disease (IBD)	0.2	0.4	1.2	-0.3	-1.0	0.9	-0.7	-1.0	0.1	-0.7	0.0	-0.1	0.3	0.0	-1.1
Ulcerative Colitis (UC)	0.3	0.5	1.7	0.9	-0.8	0.6	0.6	-0.1	0.6	0.6	0.6	0.4	1.3	0.6	-0.7
Major Depression (MDD)	0.4	0.5	1.0	0.5	0.4	0.9	-0.5	-0.1	0.9	0.1	0.9	1.0	-1.0	0.8	-0.4
Reaction Time	0.7	1.2	2.5	1.1	1.6	0.8	0.9	0.2	1.1	1.2	1.1	1.3	1.2	0.9	1.3
Verbal and Numeric Reasoning (VNR)	3.0	7.1	21.1	-1.4	-2.2	3.7	-4.6	-4.2	0.6	-3.5	0.5	0.3	-3.2	0.7	-1.4
Breast Cancer	2.0	4.7	9.9	-2.3	-1.4	1.7	-3.0	-2.9	-1.8	-3.1	-2.1	-1.8	-1.9	-1.6	-1.7
Ovarian Cancer	0.4	0.6	1.6	1.2	0.8	0.4	0.7	0.0	0.6	0.7	0.7	0.7	1.2	0.6	0.7
Prostate Cancer	0.9	1.2	7.2	0.8	1.1	-0.0	0.9	-0.4	0.9	1.1	1.0	0.9	2.7	0.8	0.7
Age at First Birth	1.1	1.5	3.8	-1.0	-0.4	-0.9	-0.4	0.3	-1.9	-1.2	-1.9	-1.7	-1.1	-1.8	0.4
Bipolar Disorder (2011)	0.3	0.3	1.1	-0.2	-1.0	-0.6	0.0	0.2	-0.5	-0.1	-0.4	-0.7	0.2	-0.5	-0.7
Body Mass Index (BMI) (2010)	3.1	4.2	13.8	0.4	-0.8	3.7	-2.7	-3.3	1.7	-1.3	1.4	1.8	-0.7	1.6	-2.3
Coronary Artery Disease (CAD)	0.3	0.3	1.1	-0.1	0.3	-0.1	0.2	0.9	-0.5	0.1	-0.7	0.1	-0.8	-0.5	-1.0
Crohns Disease (2012)	0.7	1.1	4.0	0.0	-1.4	1.4	-1.3	-2.0	0.7	-0.8	0.5	0.6	-0.2	0.6	-1.3
Mean Putamen Volume	0.9	1.0	3.5	0.5	1.9	1.3	-0.8	-0.8	1.0	-0.0	1.0	1.0	0.3	1.0	1.0
Fasting Glucose	1.1	1.3	5.3	-0.5	-0.4	1.7	-1.7	-2.3	0.4	-1.3	0.2	0.3	-1.0	0.3	-1.1
HbA1C	0.6	0.7	5.6	-0.3	-2.4	-0.2	-0.6	-0.2	-0.6	-0.3	-0.5	-0.4	-0.3	-0.5	-1.0
HDL Cholesterol	0.2	0.3	2.1	0.1	1.5	0.7	-0.2	-0.6	0.1	-0.2	0.3	0.2	0.4	0.1	0.7
LDL Cholesterol	0.1	0.1	0.5	0.5	-0.7	0.2	-0.1	-0.2	0.2	-0.0	0.2	0.3	0.5	0.3	0.3
Lupus	0.8	1.2	3.7	-0.9	1.4	-1.9	0.7	1.6	-0.8	0.2	-0.8	-0.8	-0.4	-1.0	1.1
Neuroticism (2016)	0.8	1.2	3.1	-0.2	-0.5	1.8	-1.6	-1.7	0.5	-1.0	0.5	0.5	-1.6	0.5	-1.0
Primary Biliary Cirrhosis	1.2	1.8	3.2	1.8	-0.8	0.9	0.8	0.1	1.8	1.4	1.8	1.6	1.6	1.7	-0.3
Rheumatoid Arthritis	0.2	0.3	0.8	0.1	0.9	-0.4	0.5	0.4	-0.5	0.3	-0.5	-0.4	0.7	-0.6	0.4
Schizophrenia (2014)	1.5	3.2	8.4	-1.6	-2.0	-2.9	0.5	0.8	-2.2	-0.5	-2.0	-2.3	0.7	-2.2	-1.6
Triglycerides	3.4	5.6	13.3	2.8	-0.3	2.6	0.4	-0.5	3.4	1.9	3.1	3.3	-0.3	3.6	1.5
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.6	0.8	0.2	0.6	0.0	-0.2	0.7	0.1	0.8	0.4	-0.6	0.6	-0.3
Ulcerative Colitis	0.7	1.0	5.1	0.0	-2.3	0.5	-0.3	-0.8	-0.0	-0.3	-0.1	-0.3	1.2	-0.0	-2.2
Blood Eosinophil Count	0.5	4.1	16.7	-0.7	-0.1	4.1	-2.9	-2.9	1.4	-1.8	1.1	1.3	-2.0	1.5	-0.3
Blood Platelet Count	0.1	1.4	4.8	-0.2	-1.1	1.0	-1.2	-2.2	1.1	-0.5	1.0	1.3	-0.9	1.1	-1.6
Blood Red Count	0.2	1.8	4.1	0.8	2.0	2.0	0.1	0.3	1.5	0.8	1.5	1.6	-0.5	1.6	1.5
Blood White Count	0.9	6.6	18.7	-2.0	-1.3	3.9	-4.0	-3.1	0.3	-2.9	0.1	-0.5	-4.3	0.6	-2.3
Heel T-Score	0.9	7.5	17.1	-4.1	-3.4	-2.4	-3.1	-2.9	-1.9	-3.3	-2.0	-1.9	-0.3	-1.9	-3.5
BMI	2.7	15.4	39.8	-1.2	-2.3	6.2	-6.3	-5.9	1.8	-4.3	1.1	1.7	-4.4	1.7	-4.0
Height	0.0	0.4	1.4	0.1	0.2	-1.1	-0.4	-0.3	-0.4	-0.7	-0.7	0.2	-1.0	-0.4	-1.2
Waist Hip Ratio (WHR)	1.1	4.9	13.4	2.3	-0.3	3.7	0.1	0.9	2.6	1.1	2.5	2.7	-3.4	2.5	0.6
Systolic Blood Pressure	0.2	1.1	5.6	1.2	0.5	2.4	-0.9	-0.7	0.9	-0.2	0.8	0.8	-1.1	1.1	0.1
Smoking Status	1.8	4.2	12.1	1.2	2.3	-2.2	2.8	2.2	1.1	2.6	1.2	1.1	1.7	0.9	3.5
Allergy or Eczema	0.3	0.9	1.6	1.0	0.9	0.2	0.9	1.1	1.1	1.2	1.2	0.8	-0.1	1.3	0.5
Cardiovascular Disease	0.8	2.5	6.1	1.7	1.0	2.5	-0.1	-0.2	2.0	0.8	1.9	2.1	-1.5	2.0	1.2
Hypothyroidism (self reported)	0.5	1.2	3.4	-1.9	-0.6	-0.1	-1.1	0.2	-1.3	-1.3	-1.3	-1.3	-1.2	-1.2	-0.2
Respiratory disease	1.8	3.9	8.2	2.0	-1.0	2.5	-0.5	-1.0	2.9	0.9	2.7	2.7	0.1	2.8	-1.5
Type 2 Diabetes (T2D) (2018)	3.0	5.6	17.4	1.2	0.6	4.2	-2.2	-2.6	2.7	-0.8	2.5	2.5	-2.7	2.8	0.1
Lung FEV1/FVC ratio	0.4	2.2	4.2	-1.5	-1.1	2.0	-2.0	-1.6	-0.8	-2.0	-1.1	-0.9	-1.7	-0.8	-1.6
Lung FVC	0.2	0.9	4.5	0.3	0.2	2.1	-0.9	-1.5	0.9	-0.1	0.8	0.9	-0.1	0.8	0.4
Neuroticism	0.2	0.5	1.1	0.8	-0.3	0.5	-0.1	0.2	0.9	0.3	0.9	0.7	-1.1	0.9	-0.7
Chronotype (morning person)	1.1	2.6	6.3	1.9	-0.7	2.5	-0.3	-1.1	2.2	0.6	2.1	2.2	0.0	2.2	0.5
Hair Pigment	0.0	0.8	2.9	0.7	1.2	-1.1	0.8	0.4	0.7	1.0	0.7	0.7	1.7	0.6	0.1
Tanning	0.3	4.1	8.4	2.0	0.8	-1.0	2.7	2.7	1.9	2.9	2.0	2.0	1.8	1.9	1.8
Hand grip strength (left)	1.5	4.1	6.3	-2.1	-1.7	-1.0	-1.8	-1.6	-2.5	-2.4	-2.5	-2.4	-1.1	-2.4	-2.1
Number of treatments/medications taken	1.6	2.9	4.3	2.1	1.8	0.4	1.6	1.8	1.8	1.9	1.7	2.0	-0.1	1.7	2.0
Average weekly spirits intake	1.4	1.7	4.1	-1.6	0.7	-2.0	0.3	0.4	-1.7	-0.6	-1.7	-1.7	0.6	-1.8	0.7
Sensitivity / hurt feelings	0.9	1.6	6.5	-0.0	0.7	-2.5	1.9	1.5	-0.7	1.3	-0.5	-0.7	1.1	-0.7	1.2
Frequency of depressed mood in last 2 weeks	0.1	0.2	1.1	-0.2	-0.1	0.1	-0.8	-0.5	0.0	-0.6	-0.2	0.1	0.1	-0.2	-1.1
Hearing difficulty/problems: Yes	0.4	0.6	1.7	0.2	0.4	0.5	-0.7	-1.3	0.9	-0.3	0.9	0.8	-0.0	0.8	-0.9
Relative age of first facial hair	0.8	1.6	3.7	0.1	1.7	-1.4	1.8	1.9	-0.0	1.5	0.2	0.0	1.6	-0.1	1.4
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.5	-0.4	-0.6	1.6	-1.3	-1.1	0.5	-1.0	0.3	0.6	-1.4	0.5	-1.2
Ever used hormone-replacement therapy (HRT)	1.6	2.1	3.5	1.8	0.6	0.1	1.6	1.3	1.8	1.9	1.9	1.6	1.0	1.6	0.6
Ever had hysterectomy (womb removed)	2.2	2.5	5.0	1.5	1.6	1.3	0.3	-0.9	2.2	1.1	2.0	2.0	1.9	2.1	0.0
Systolic blood pressure, automated reading	0.1	0.3	1.3	1.0	-0.3	1.2	-0.2	0.3	0.4	0.2	0.5	0.2	-0.6	0.6	-0.0
Eye problems/disorders: Diabetes related eye disease	2.9	3.2	7.2	2.1	1.1	1.5	0.5	0.4	2.5	1.4	2.6	2.7	-0.1	2.6	1.1
Angina	0.3	0.4	1.3	0.3	0.2	-0.5	1.1	1.2	-0.5	0.5	-0.3	-0.4	-0.3	-0.5	0.7
Medication for hormone replacement therapy	0.2	0.2	0.8	0.2	-0.9	-0.0	-0.1	-0.1	0.5	0.2	0.5	0.1	0.6	0.5	-0.3
Vitamin and mineral supplements	0.2	0.3	0.8	-0.2	-0.3	-0.1	0.7	0.9	0.4	0.7	0.5	0.2	-0.9	0.4	0.5
Supplements: Zinc	0.7	0.8	2.3	0.1	0.4	1.5	-1.5	-1.1	0.2	-1.1	-0.1	0.4	-1.5	0.3	-0.1
Medication: Co-codamol	0.8	0.9	1.9	-0.7	1.2	-1.3	0.8	0.8	-1.3	0.1	-1.2	-1.1	0.4	-1.4	0.4
Medication: Metformin	1.3	1.9	4.2	1.5	1.5	2.0	-0.4	-1.1	1.7	0.3	1.8	1.5	-1.0	1.8	0.6
Diabetes (father)	0.2	0.3	1.1	0.0	-0.2	1.0	-1.1	-0.3	0.0	-0.8	-0.2	-0.2	-0.8	-0.0	-0.1
Diabetes (mother)	2.3	3.0	6.4	2.3	-0.4	1.8	-0.2	-0.6	2.5	1.0	2.5	2.4	1.0	2.5	-0.5
Severe depression (siblings)	1.2	1.4	5.8	-0.7	-1.4	0.8	-1.7	-1.6	0.1	-1.3	-0.2	-0.0	-0.5	0.1	-2.4
Pack years adult smoking proportion	0.1	0.1	0.7	-0.1	-0.8	-0.1	-0.2	0.3	-0.1	-0.1	-0.3	-0.0	-0.0	-0.1	-0.4
Impedance of leg (right)	0.4	1.8	5.0	1.3	-0.1	-0.5	2.2	2.1	0.6	2.1	0.7	0.7	0.5	0.7	2.0
Leg fat-free mass (left)	0.8	4.1	11.3	-0.2	-0.2	2.7	-3.4	-3.3	1.1	-2.2	0.6	1.1	-1.8	1.0	-2.8
Trunk fat percentage	2.7	10.8	27.4	-1.6	-2.3	4.7	-5.2	-4.0	0.6	-4.0	0.0	0.8	-5.1	0.5	-3.7
Hand grip strength (right)	0.6	1.7	3.6	-1.1	-1.4	0.2	-1.7	-1.4	-1.1	-1.7	-1.3	-0.9	-1.1	-1.0	-1.9
Townsend deprivation index at recruitment	2.2	3.2	5.7	1.8	1.8	1.3	0.8	-0.1	2.3	1.7	2.4	2.3	1.7	2.4	1.1
Current tobacco smoking	3.3	5.4	11.1	2.3	2.8	-0.9	2.5	1.8	1.7	2.6	1.8	1.7	3.3	1.7	3.3
Average weekly fortified wine intake	0.8	1.0	2.8	-1.0	-1.7	-1.4	-0.0	0.4	-1.1	-0.6	-1.0	-1.2	0.8	-1.0	0.1
Maternal smoking around birth	1.7	2.4	5.5	1.9	1.0	1.7	-0.1	-0.7	2.3	0.8	2.3	2.3	0.1	2.1	-0.4
Fed-up feelings	2.4	4.4	9.4	1.5	1.3	2.7	-1.3	-1.4	3.1	0.4	2.9	3.0	-0.1	2.9	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	4.9	1.3	0.0	2.2	-1.2	-1.2	1.8	-0.1	1.4	1.7	-0.9	1.8	-0.8
Relative age voice broke	0.7	1.0	2.5	-0.5	0.2	-1.6	1.2	1.5	-1.1	0.3	-1.0	-0.9	0.6	-1.2	0.8
Taking other prescription medications	0.6	0.9	1.7	1.3	0.8	0.6	0.7	1.3	1.1	0.9	1.0	1.3	0.0	1.0	0.3
Age when periods started (menarche)	0.3	0.8	2.0	0.9	0.9	-0.1	1.2	0.1	0.8	1.2	0.9	1.0	1.4	0.8	0.3
Bilateral oophorectomy (both ovaries removed)	3.5	4.0	6.9	2.6	1.5	0.0	2.0	1.8	2.3	2.6	2.4	2.1	2.0	2.2	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.9	1.9	5.5	-0.8	-1.8	0.8	-2.2	-2.4	0.8	-1.5	0.8	0.8	-0.5	0.8	-1.8
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	2.6	1.3	0.6	0.3	0.6	-0.1	1.2	1.1	1.4	0.8	1.6	1.1	0.0
Qualifications: CSEs or equivalent	0.5	0.6	1.5	0.6	0.2	0.4	0.7	0.2	0.9	1.2	1.0	0.8	1.2	0.8	-0.2
Serious illness, injury or assault to yourself	0.4	0.5	2.7	-0.3	1.6	-0.5	0.5	0.4	-0.4	0.2	-0.4	-0.4	0.8	-0.3	0.9
High blood pressure	0.3	1.0	3.0	1.3	1.2	1.7	0.0	0.1	1.0	0.4	0.9	1.1	-0.5	1.0	0.9
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.5	-0.0	0.4	0.5	-0.1	0.3	0.4	-0.0	0.4	0.2	-0.7	0.5	0.2
Multivitamins +/- minerals	0.2	0.3	1.6	0.4	0.4	-0.5	0.1	-0.1	-0.6	-0.2	-0.7	-0.4	1.3	-0.6	-0.0
Stomach or abdominal pain in last month	2.4	3.0	7.6	1.8	1.3	2.8	-0.4	-1.2	2.3	0.7	2.3	2.1	0.3	2.2	-0.8
Supplements: Glucosamine	0.3	0.4	0.8	-0.8	0.4	0.6	-0.8	-0.6	-0.4	-0.9	-0.6	-0.2	-0.9	-0.5	-0.2
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.4	-0.8	-0.5	1.4	-1.7	-1.8	-0.5	-1.5	-0.7	-0.4	0.2	-0.6	-1.6
Medication: Atenolol	3.1	3.9	8.6	-2.1	-1.3	-1.6	-0.5	0.3	-2.9	-1.8	-2.7	-2.8	-1.4	-2.9	-0.6
Medication: Levothyroxine sodium	1.0	1.8	3.5	-1.6	-0.6	-1.8	0.4	0.9	-1.8	-0.4	-1.8	-1.7	0.5	-1.9	0.6
Sitting height	0.3	1.9	9.9	0.5	-0.4	-3.1	1.9	1.9	-0.4	1.3	-0.5	-0.4	1.3	-0.4	-0.9
Chronic bronchitis/emphysema (father)	0.7	0.8	1.9	1.1	-0.1	0.9	0.1	-0.5	1.3	0.6	1.1	1.4	1.0	1.3	0.1
High blood pressure (mother)	1.0	1.4	2.5	-1.3	1.0	0.1	-1.0	-1.5	-1.4	-1.6	-1.6	-1.1	-0.0	-1.6	0.2
Body mass index (BMI)	1.9	8.1	21.8	-1.2	-1.4	4.2	-4.7	-3.9	0.7	-3.4	0.2	0.7	-3.8	0.6	-3.3
Impedance of leg (left)	0.2	0.9	2.6	0.9	-1.2	-0.4	1.6	1.5	0.3	1.5	0.4	0.4	0.4	0.3	0.9
Leg predicted mass (left)	0.8	4.1	11.3	-0.2	-0.1	2.7	-3.4	-3.3	1.1	-2.2	0.6	1.2	-1.8	1.0	-2.8
Trunk fat mass	2.5	10.9	28.1	-1.4	-2.0	4.6	-5.3	-4.1	0.8	-4.0	0.1	1.0	-5.0	0.6	-4.0
Waist circumference	2.9	10.6	27.8	-0.5	-1.9	5.3	-4.8	-4.0	1.7	-3.2	1.1	1.8	-5.0	1.5	-3.5
Number of incorrect matches in round	3.4	5.6	16.1	1.2	1.8	-3.2	4.0	3.9	-0.1	2.9	0.2	0.1	2.7	-0.3	2.3
Past tobacco smoking	0.7	1.2	3.4	-0.6	-0.8	1.1	-1.3	-0.8	-1.1	-1.4	-1.0	-1.2	0.3	-0.8	-1.8
Alcohol usually taken with meals	0.2	0.4	1.8	-0.4	-1.3	0.1	-0.4	-0.4	-0.6	-0.6	-0.8	-0.7	-0.0	-0.6	-0.2
Nervous feelings	0.3	0.6	1.9	0.7	1.4	-0.3	0.7	0.9	0.7	0.9	0.7	0.7	0.3	0.6	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.1	0.2	0.4	0.5	-1.1	-0.9	0.4	-0.7	0.1	0.3	0.2	0.3	-0.3
Hearing difficulty/problems with background noise	0.5	0.9	4.4	0.5	1.1	-1.3	1.1	0.3	0.3	0.9	0.4	0.3	2.1	0.2	0.4
Hair/balding pattern: Pattern 2	0.5	0.7	2.8	0.2	-1.4	0.9	-0.7	-1.3	0.4	-0.3	0.1	0.5	0.3	0.3	-1.7
Had menopause	0.6	0.7	1.7	1.1	0.3	0.2	1.1	1.3	0.9	1.0	0.9	0.8	-0.0	0.8	0.5
Had other major operations	1.0	1.2	2.8	-0.8	-1.0	1.1	-1.6	-1.2	-0.5	-1.7	-0.6	-0.5	-1.6	-0.4	-1.1
Forced vital capacity (FVC)	0.5	1.8	6.2	0.2	-0.8	2.2	-1.9	-2.5	0.8	-0.9	0.5	0.8	-0.5	0.8	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	3.9	-0.4	-1.2	0.4	-1.6	-2.0	0.9	-1.0	0.8	0.8	0.3	0.8	-1.2
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	3.8	1.7	1.2	0.4	1.1	0.8	1.9	1.5	1.9	1.9	0.5	1.8	0.7
Qualifications: None of the above	0.7	1.5	3.6	1.5	0.1	-0.8	1.9	1.3	0.9	1.8	1.0	0.8	1.8	0.9	-0.0
Financial difficulties in last 2 years	0.2	0.2	1.1	-0.4	0.3	-0.9	-0.3	-0.1	-0.2	-0.3	-0.2	-0.0	0.1	-0.3	1.1
Mouth/teeth dental problems	0.2	0.3	1.9	0.3	0.1	0.4	0.0	0.1	0.7	0.5	0.6	0.6	0.1	0.7	1.4
Heart attack	0.5	0.6	2.6	0.1	0.5	-0.8	0.9	1.0	-0.4	0.5	-0.3	-0.3	-1.0	-0.2	1.6
Allergy	0.4	0.9	2.1	-1.1	-0.6	-0.9	-0.3	-0.2	-1.4	-0.7	-1.3	-1.3	0.5	-1.4	-0.2
Pain all over the body in last month	1.4	1.5	3.4	1.7	0.2	0.4	0.6	0.1	1.8	1.3	1.8	1.7	0.4	1.6	0.3
Diabetes (self-reported)	1.3	2.1	5.9	0.7	2.4	1.8	-1.0	-1.3	1.3	-0.4	1.2	1.3	-1.7	1.3	1.8
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.4	-1.3	-0.6	0.7	-1.3	-0.8	-0.7	-1.3	-0.7	-0.8	-1.5	-0.6	-1.2
Medication: Ramipril	0.5	0.6	1.9	0.5	1.3	1.3	-0.4	0.5	0.2	-0.1	-0.0	0.5	-1.2	0.3	1.4
Medication: Simvastatin	1.0	1.5	9.1	0.6	1.4	-1.1	1.5	1.2	-0.3	1.0	-0.2	0.1	0.8	-0.2	3.0
Fluid intelligence score	1.9	3.9	11.1	-1.9	-1.9	1.6	-3.3	-2.6	-0.6	-2.9	-0.6	-0.7	-2.7	-0.6	-1.1
Illnesses of siblings	0.4	0.5	1.8	0.7	0.1	-0.6	0.9	1.1	0.4	0.9	0.5	0.4	1.4	0.4	0.3
Neuroticism score	0.6	1.2	2.6	1.2	0.8	0.5	0.4	0.6	1.6	1.1	1.6	1.5	-0.2	1.6	0.1
Weight	1.8	8.8	23.9	-1.1	-1.4	3.9	-4.9	-4.2	0.8	-3.6	0.1	0.9	-3.8	0.6	-4.0
Impedance of arm (right)	0.0	0.1	0.7	-0.0	0.3	0.2	0.2	0.2	0.1	0.1	0.1	0.2	-0.3	0.1	0.8
Arm fat percentage (right)	3.0	11.8	31.2	-0.9	-1.3	5.6	-5.5	-4.6	1.4	-3.8	0.8	1.4	-4.5	1.3	-3.8
Trunk fat-free mass	0.4	2.3	8.1	0.0	-0.4	1.6	-2.4	-2.5	0.5	-1.7	0.1	0.6	-1.2	0.5	-2.8
Hip circumference	1.6	7.0	20.0	-1.4	-1.6	3.1	-4.5	-4.0	0.5	-3.3	-0.0	0.6	-3.1	0.5	-3.5
Time employed in main current job	2.3	2.7	7.1	1.6	2.4	-1.3	2.3	2.1	0.4	1.9	0.4	0.5	1.1	0.5	2.7
Alcohol intake versus 10 years previously	0.2	0.4	1.1	-0.9	-0.2	-0.1	-0.2	-0.1	-0.7	-0.5	-0.6	-0.8	-0.1	-0.8	-1.1
Father’s age at death	1.7	2.2	5.2	-1.5	-2.2	1.4	-2.3	-2.0	-0.5	-2.1	-0.6	-0.5	-1.0	-0.6	-1.4
Worrier / anxious feelings	0.1	0.2	1.0	0.1	0.3	-0.2	-0.1	0.5	-0.3	-0.1	-0.3	-0.3	-1.0	-0.1	0.4
Frequency of tiredness / lethargy in last 2 weeks	4.6	7.4	21.4	0.2	-0.7	4.5	-4.0	-4.6	2.0	-2.3	1.5	2.0	-2.1	2.0	-2.7
Falls in the last year	1.8	2.5	8.3	1.2	2.9	-0.8	1.8	1.2	0.9	1.8	1.1	0.7	2.1	0.8	1.8
Hair/balding pattern: Pattern 3	0.1	0.2	0.6	0.3	0.2	0.1	0.3	-0.1	0.7	0.5	0.8	0.6	0.2	0.7	0.4
Number of live births	0.2	0.3	0.8	0.9	0.9	-0.3	0.9	0.8	0.2	0.7	0.3	0.2	-0.1	0.2	0.0
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	7.8	-0.1	-1.6	2.7	-2.3	-2.8	0.7	-1.3	0.3	0.7	-0.8	0.8	-2.2
Pulse rate	3.8	6.3	11.0	2.9	2.0	1.3	1.7	0.3	3.3	2.8	3.3	3.0	2.4	3.3	1.9
Happiness	1.6	2.0	4.5	-0.2	-1.4	2.0	-2.1	-1.8	0.5	-1.4	0.3	0.6	-1.9	0.5	-2.1
Noisy workplace	1.2	1.5	5.1	0.2	1.4	2.3	-1.7	-1.7	1.0	-0.9	0.8	1.2	-0.7	1.0	0.3
Qualifications: A levels/AS levels or equivalent	4.4	9.7	17.5	-4.1	-1.6	-2.1	-2.6	-1.3	-4.1	-3.7	-4.2	-3.8	-2.1	-4.1	-0.7
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	6.1	1.4	1.2	0.5	0.5	-0.1	1.6	1.1	1.5	1.5	2.5	1.6	0.3
Mouth/teeth dental problems: Dentures	0.7	1.2	3.9	1.6	0.4	-0.9	1.7	1.1	0.5	1.4	0.6	0.5	2.0	0.4	-0.3
Asthma	1.1	2.1	4.4	1.2	-0.3	2.0	-1.0	-1.2	2.1	0.1	1.7	2.0	-0.6	2.1	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.6	-0.2	0.1	-0.7	0.8	0.8	-0.1	0.4	0.0	-0.2	0.3	-0.1	0.6
Medication: Cholesterol lowering	2.3	3.5	10.3	1.8	1.5	-1.3	2.7	2.9	0.7	2.4	0.9	1.0	0.8	0.7	3.2
Depression (self-reported)	1.1	1.3	2.9	1.6	1.3	1.1	-0.3	-0.7	1.7	0.5	1.5	1.5	0.3	1.6	0.4
Medication: Lansoprazole	0.2	0.2	0.6	0.8	0.5	-0.3	0.5	0.6	0.2	0.6	0.1	0.2	0.3	0.2	0.2
Prospective memory result	0.5	0.7	2.0	0.5	0.7	-0.9	1.3	1.3	-0.0	1.0	0.0	-0.2	1.4	-0.0	0.1
Lung cancer (father)	3.4	4.0	7.8	2.7	1.0	1.4	1.0	0.4	2.7	2.1	2.8	2.6	1.6	2.7	0.5
Illnesses of mother	0.7	0.9	1.9	0.9	0.2	-0.6	1.3	1.2	0.7	1.4	0.8	0.9	0.4	0.9	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	11.1	-0.4	-2.2	2.9	-3.0	-3.3	0.6	-1.9	0.1	0.6	-0.9	0.6	-2.9
Pulse wave Arterial Stiffness index	0.7	0.8	6.1	-0.1	0.7	-0.3	0.8	1.0	0.0	0.4	-0.0	0.5	-0.7	0.1	2.5
Impedance of arm (left)	0.1	0.3	1.6	-0.1	0.6	-0.5	0.7	1.0	-0.1	0.6	0.0	0.1	0.2	-0.1	1.3
Arm fat mass (right)	2.7	11.0	28.8	-1.1	-1.6	4.9	-5.4	-4.5	1.1	-3.9	0.4	1.1	-4.4	0.9	-4.2
Trunk predicted mass	0.4	2.2	7.8	0.1	-0.5	1.5	-2.3	-2.4	0.5	-1.6	0.1	0.6	-1.1	0.5	-2.8
Standing height	0.1	0.6	3.6	0.1	-0.2	-0.1	-1.0	-0.9	0.1	-0.8	-0.4	0.5	-0.8	0.1	-1.9
Length of working week for main job	0.6	0.6	2.3	-0.2	0.9	-1.5	1.0	1.2	-0.4	0.6	-0.0	-0.5	0.8	-0.6	0.8
Exposure to tobacco smoke at home	2.7	3.1	6.1	-2.1	-2.1	0.6	-1.9	-1.6	-1.6	-2.1	-1.5	-1.7	-0.9	-1.6	-2.5
Breastfed as a baby	0.8	1.0	3.2	-1.8	-0.5	-0.6	-0.7	-0.3	-1.1	-1.1	-1.1	-1.0	-1.3	-1.1	-0.4
Tense / ‘highly strung’	0.1	0.2	0.8	0.6	0.6	-0.0	0.5	0.9	-0.0	0.4	-0.2	0.1	-0.4	-0.1	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	4.4	0.8	0.2	2.1	-1.5	-1.5	1.8	-0.3	1.5	1.8	-0.1	1.7	-1.2
Hair/balding pattern: Pattern 4	0.4	1.1	2.8	1.2	1.6	1.7	-0.4	-0.4	1.2	0.2	1.2	1.2	-0.1	1.2	0.1
Birth weight of first child	0.9	1.7	5.8	-0.6	-0.8	1.9	-2.1	-1.4	0.4	-1.6	0.1	0.5	-2.4	0.3	-0.6
Peak expiratory flow (PEF)	0.8	1.9	4.6	-1.2	-2.2	0.6	-1.9	-1.9	-0.8	-1.6	-1.0	-0.8	-1.5	-0.7	-1.4
Pulse wave reflection index	1.2	1.4	7.2	-1.3	-1.1	0.6	-1.4	-0.0	-0.9	-1.5	-1.0	-0.4	-2.7	-0.7	0.1
Ever highly irritable/argumentative for 2 days	0.2	0.2	1.1	-0.7	-0.3	-1.0	-0.1	-0.1	-0.5	-0.3	-0.6	-0.4	-0.0	-0.6	-0.2
Loud music exposure frequency	0.1	0.1	0.3	-0.1	0.3	0.3	0.1	0.3	0.4	0.1	0.5	0.6	-0.3	0.3	0.3
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	3.7	-1.7	0.0	-1.6	-0.1	0.4	-1.9	-0.9	-1.7	-1.8	-0.1	-1.9	0.2
Mouth/teeth dental problems: Bleeding gums	1.5	2.0	4.8	-1.6	-1.2	0.9	-2.2	-1.9	-0.8	-2.0	-0.8	-0.7	-1.7	-0.6	-1.4
Blood clot in the leg (DVT)	0.2	0.3	1.1	0.4	1.1	-0.6	0.4	0.7	-0.3	0.2	-0.1	-0.5	0.6	-0.2	0.3
Medication: Paracetamol	0.7	1.1	2.8	0.7	0.7	0.5	0.3	-0.1	1.6	1.0	1.5	1.7	1.0	1.5	-0.3
Headache pain in last month	0.6	1.0	4.1	-0.3	-0.3	1.6	-1.4	-1.2	0.4	-0.9	0.4	0.4	0.6	0.4	-2.0
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	5.5	-1.1	-1.3	0.3	-1.4	-1.5	-0.3	-1.2	-0.3	-0.7	-0.2	-0.2	-2.4
Glaucoma (self-reported)	0.2	0.3	0.5	0.5	0.7	0.1	0.6	0.1	0.6	0.7	0.6	0.7	0.4	0.5	0.3
Gout (self-reported)	0.9	1.2	3.3	-1.3	-1.8	-0.8	-0.0	0.6	-1.3	-0.6	-1.1	-1.3	-0.8	-1.4	-0.8
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	4.6	-2.1	-0.5	-0.3	-1.2	0.0	-1.8	-1.7	-2.0	-1.7	-0.9	-1.8	-0.4
Medication: Amlodipine	0.2	0.3	1.4	0.4	0.7	1.2	-0.1	-0.4	0.4	0.1	0.2	0.7	0.6	0.3	0.7
Medication: Ventolin 100micrograms inhaler	2.6	3.3	11.8	0.1	-0.7	2.8	-2.2	-2.6	1.4	-1.1	1.1	1.1	-0.7	1.4	-3.4
Birth weight	1.3	2.8	5.5	-2.0	-1.5	0.6	-2.3	-1.9	-0.9	-2.1	-0.9	-1.0	-2.3	-1.0	-2.1
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.0	1.3	1.4	0.1	0.5	0.5	1.4	1.1	1.4	1.3	0.4	1.3	-0.0
High blood pressure (siblings)	0.5	0.8	1.7	-1.0	-0.8	-0.9	-0.3	-0.2	-1.1	-0.6	-1.1	-1.3	-0.6	-1.1	-0.7
Forced vital capacity (FVC), Best measure	0.9	3.3	9.4	-0.0	-1.8	2.8	-2.7	-3.1	0.8	-1.6	0.3	0.9	-0.8	0.9	-2.5
Body fat percentage	2.7	10.7	26.8	-1.3	-2.2	4.9	-5.2	-4.0	0.9	-3.8	0.3	1.0	-4.9	0.8	-3.6
Leg fat percentage (right)	1.9	6.9	20.2	-0.4	-1.4	4.5	-3.9	-3.1	1.4	-2.5	0.9	1.4	-4.0	1.3	-2.7
Arm fat-free mass (right)	0.4	2.2	7.1	0.0	-0.7	1.7	-2.2	-2.1	0.7	-1.5	0.3	0.9	-1.4	0.7	-2.7
Exposure to tobacco smoke outside home	0.6	0.9	4.0	0.4	1.2	-1.0	0.9	0.7	0.3	1.0	0.5	0.4	2.0	0.2	1.0
Comparative body size at age 10	3.7	10.3	20.8	-3.9	-2.6	1.4	-4.2	-3.2	-2.6	-4.6	-2.9	-2.6	-3.5	-2.6	-3.1
Number of full brothers	0.4	0.5	2.2	-0.1	1.1	0.8	-0.8	-1.5	0.3	-0.4	0.0	0.4	-0.3	0.4	1.0
Worry too long after embarrassment	0.5	0.9	5.2	-0.2	-1.7	0.0	-0.9	-1.0	0.3	-0.6	0.4	0.1	-0.6	0.4	-2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	3.5	0.8	0.9	-0.6	1.2	1.9	0.7	1.3	0.9	0.7	-0.2	0.6	0.6
Wheeze or whistling in the chest in last year	2.0	3.5	11.2	1.0	-1.1	3.4	-2.2	-2.2	1.7	-1.0	1.4	1.6	-2.1	1.8	-1.5
Number of children fathered	5.0	5.7	9.6	2.9	2.7	-0.3	2.5	2.0	2.5	3.1	2.6	2.3	1.4	2.5	2.3
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	1.0	0.0	0.2	-0.6	0.8	-0.2	-0.2	0.6	-0.2	0.1	0.6	-0.3	1.0
Age at first live birth	1.7	3.0	6.2	-1.4	-1.9	-2.1	0.7	1.1	-2.5	-0.6	-2.3	-2.3	-0.9	-2.4	-0.9
Pulse wave peak to peak time	0.7	0.8	6.2	0.1	-0.7	0.4	-0.9	-1.2	0.1	-0.5	0.1	-0.3	0.7	0.1	-2.5
Health satisfaction	1.2	1.6	4.7	0.1	0.1	2.2	-1.7	-1.1	1.3	-0.9	0.8	1.3	-1.7	1.2	-0.8
Shortness of breath walking on level ground	0.2	0.2	0.7	-0.8	0.6	0.0	-0.4	-0.3	-0.1	-0.5	-0.4	0.1	-0.8	-0.3	0.3
Qualifications: College or University degree	3.7	11.7	23.0	-3.8	-3.6	0.8	-4.5	-3.9	-3.0	-4.8	-3.2	-2.8	-3.4	-2.8	-2.7
Eye problems/disorders: None of the above	1.8	2.1	4.5	-1.7	-0.9	-1.1	-0.8	-0.2	-2.0	-1.5	-2.1	-2.0	-1.2	-2.0	-0.1
Mouth/teeth dental problems: Loose teeth	0.5	0.5	2.2	0.4	0.8	1.2	-0.1	0.3	0.7	0.0	0.7	0.7	-1.5	0.7	0.2
Emphysema/chronic bronchitis	0.4	0.4	1.4	-0.0	0.1	1.0	-0.5	-1.2	0.5	-0.3	0.5	0.4	0.8	0.3	-1.1
Medication for pain relief, constipation, heartburn	1.9	3.3	5.2	-2.1	-1.4	0.1	-1.8	-1.3	-2.2	-2.1	-2.3	-2.3	-1.5	-2.1	-1.3
Neck or shoulder pain in last month	5.5	7.8	13.0	3.6	1.6	0.4	2.7	2.7	3.3	3.6	3.5	3.2	1.2	3.3	1.7
Medication: Blood pressure	0.4	0.7	4.5	0.8	0.7	-0.1	1.0	1.0	0.1	0.8	0.2	0.5	0.0	0.0	2.1
Angina (self-reported)	0.2	0.3	0.9	0.4	0.2	-0.2	1.0	0.9	-0.4	0.4	-0.2	-0.3	-0.3	-0.4	0.6
Migraine (self-reported)	0.3	0.3	0.8	-0.9	-0.7	-0.9	-0.2	-0.5	-0.3	-0.4	-0.3	-0.6	0.5	-0.4	-0.6
Medication: Ibuprofen	0.4	0.5	1.4	0.5	0.1	0.1	0.7	0.3	1.0	0.8	1.2	1.0	-0.0	1.1	0.2
Medication: Allopurinol	0.2	0.2	1.1	0.0	-1.0	-0.5	0.5	0.9	-0.3	0.3	-0.2	-0.3	-0.1	-0.3	0.4
Medication: Omeprazole	2.6	3.1	6.1	2.5	0.8	0.5	1.4	1.1	2.1	2.0	2.2	2.2	1.3	2.0	1.7
Medication: Seretide 50 evohaler	0.4	0.4	2.4	0.2	-0.8	-1.0	0.8	0.4	-0.1	0.6	-0.1	-0.2	0.3	-0.1	-1.5
Mean time to correctly identify matches	0.6	1.2	3.0	1.0	1.7	0.6	1.1	0.7	0.8	1.1	0.8	1.0	1.2	0.6	1.7
Heart disease (mother)	0.3	0.4	1.8	-0.8	-0.1	-0.4	-0.5	-0.0	-0.6	-0.6	-0.6	-0.6	0.2	-0.8	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.2	8.4	0.5	0.9	-2.9	2.2	2.0	-0.7	1.4	-0.3	-0.8	1.7	-0.6	1.4
Whole body fat mass	2.5	10.5	27.0	-1.2	-2.0	4.6	-5.2	-4.2	0.9	-3.8	0.3	1.0	-4.6	0.8	-4.0
Leg fat mass (right)	2.3	8.9	22.1	-0.7	-1.5	4.7	-4.6	-3.9	1.4	-3.2	0.8	1.5	-4.2	1.2	-3.4
Arm predicted mass (right)	0.4	2.3	7.8	-0.1	-0.8	1.7	-2.3	-2.3	0.7	-1.5	0.2	0.8	-1.3	0.6	-2.8
Pulse rate, automated reading	2.6	8.5	18.7	3.5	0.5	3.6	0.3	-0.5	4.2	2.1	4.2	4.2	0.2	4.3	0.3
Alcohol intake frequency.	0.0	0.1	0.3	-0.3	0.6	0.6	-0.4	-0.4	0.0	-0.3	0.1	-0.0	-0.1	-0.1	0.5
Comparative height size at age 10	0.0	0.1	1.0	0.2	1.0	-0.2	-0.2	-0.6	0.1	-0.2	-0.0	0.2	0.0	0.1	0.0
Number of full sisters	0.6	0.7	2.9	0.2	-0.6	1.2	-1.2	-1.7	0.5	-0.7	0.2	0.5	-0.9	0.5	-0.0
Suffer from ‘nerves’	1.7	2.6	5.7	2.1	-0.3	2.4	-0.5	-0.5	2.3	0.7	2.1	2.3	-0.1	2.3	-0.4
Overall health rating	3.0	6.4	16.0	2.1	0.9	4.0	-1.5	-1.6	3.6	0.2	3.1	3.7	-1.2	3.5	-0.2
Chest pain or discomfort	1.8	2.5	5.9	1.4	0.5	2.4	-1.4	-2.0	2.0	-0.3	1.9	2.1	-0.4	1.9	-0.4
Had major operations	3.3	3.9	6.7	1.7	2.5	-0.9	2.6	2.3	1.6	2.6	1.7	1.5	1.3	1.4	2.5
Age at last live birth	0.7	1.0	2.8	-0.7	-1.7	-0.4	0.0	-0.1	-1.2	-0.5	-0.9	-1.0	-1.0	-1.0	-1.6
Family relationship satisfaction	2.3	2.9	8.0	-0.1	-1.6	2.8	-2.2	-1.7	1.1	-1.3	0.9	1.1	-2.7	1.2	-1.5
Leg pain on walking	1.9	2.3	6.3	1.4	0.8	1.4	0.2	-0.4	2.3	1.2	2.1	2.5	0.6	2.2	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.2	1.5	-0.2	0.6	0.8	1.2	1.3	1.2	1.3	1.4	-0.5	1.2	0.2
Commuting to job workplace: Car/motor vehicle	0.2	0.3	1.2	-0.7	-0.7	-0.0	-0.4	-0.2	-0.1	-0.4	-0.1	-0.0	-1.1	-0.1	-0.7
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.7	-0.4	-1.3	-0.7	0.8	0.9	-0.7	0.3	-0.5	-0.7	-0.9	-0.7	-0.5
Medication: Aspirin	0.2	0.3	1.1	0.5	-0.4	-0.7	0.9	0.8	-0.1	0.5	-0.1	0.1	0.2	-0.1	1.0
Supplements: Vitamin C	1.5	1.8	4.4	-1.6	0.1	0.0	-2.1	-1.6	-1.3	-2.0	-1.5	-1.3	-1.0	-1.1	-0.2
Knee pain experienced in last month	1.0	1.5	4.3	1.3	-0.4	2.1	-0.6	-1.2	1.6	0.1	1.3	1.9	-0.6	1.5	0.2
Hypertension (Self-reported)	1.0	2.7	4.9	2.2	1.9	2.2	0.6	0.4	1.9	1.2	1.8	2.0	-0.2	1.9	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	4.2	0.5	0.1	2.1	-1.1	-0.8	0.7	-0.5	0.6	0.9	-0.2	0.8	-0.5
Illnesses of father: Heart disease	0.3	0.5	2.2	-0.5	-0.4	-1.0	-0.0	0.2	-0.8	-0.3	-0.7	-0.5	-1.5	-0.8	-0.1
Illnesses of siblings: Diabetes	1.6	1.9	5.9	0.6	-1.3	2.4	-1.9	-2.0	1.0	-1.0	0.8	0.8	-1.6	1.1	-0.8
Smoking status: Previous	0.6	1.0	3.0	0.6	0.3	-1.7	1.5	1.0	0.7	1.4	0.7	0.8	-0.1	0.5	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.4	1.5	-1.2	0.7	-0.4	-0.7	1.4	0.4	1.2	1.5	0.7	1.4	-1.4
Whole body fat-free mass	0.6	3.3	9.4	-0.2	-0.6	2.1	-2.9	-2.9	0.7	-2.0	0.2	0.8	-1.5	0.6	-3.1
Leg fat-free mass (right)	0.9	4.9	13.8	-0.5	-0.6	2.8	-3.7	-3.7	0.8	-2.6	0.3	1.0	-1.7	0.8	-3.4
Arm fat percentage (left)	2.6	10.5	27.8	-1.0	-1.3	5.3	-5.3	-4.1	1.3	-3.6	0.8	1.4	-4.4	1.2	-3.6
Average weekly red wine intake	0.2	0.3	1.4	0.7	0.6	-0.0	0.4	1.1	-0.1	0.2	-0.1	0.2	-0.6	-0.1	1.2
Handedness (chirality/laterality): Left-handed	0.5	0.6	3.1	-0.9	-0.6	0.2	-0.6	0.0	-0.7	-0.8	-0.7	-0.7	-1.8	-0.7	-0.1
Mood swings	0.4	0.7	1.6	0.7	1.0	-0.2	0.6	0.2	1.0	0.8	1.1	1.0	1.2	0.9	-0.4
Loneliness, isolation	2.0	2.7	6.6	1.5	-0.2	2.6	-1.2	-0.9	2.4	0.1	2.1	2.3	-0.1	2.4	-0.7
Long-standing illness, disability or infirmity	0.6	0.9	2.2	1.4	0.2	1.1	0.1	-0.1	1.4	0.7	1.2	1.4	-0.4	1.5	0.0
Ever had bowel cancer screening	1.2	1.4	2.6	1.2	0.9	-0.5	1.6	1.6	1.1	1.6	1.2	1.0	1.5	0.8	0.8
Diabetes diagnosed by doctor	1.8	3.0	8.2	0.8	1.5	2.9	-1.7	-1.9	1.8	-0.8	1.5	1.8	-2.2	1.8	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.6	1.2	0.6	0.4	1.1	1.0	1.1	1.3	1.1	1.0	-0.3	1.2	1.1
Friendships satisfaction	1.6	2.0	7.3	-0.8	-2.2	1.5	-1.8	-1.5	0.1	-1.4	-0.2	0.4	-2.7	0.0	-1.3
Qualifications: nursing, teaching	1.9	3.0	6.9	-2.5	-0.3	-0.1	-1.8	-0.6	-2.0	-2.1	-2.0	-1.9	-2.6	-1.8	-0.2
Commuting to job workplace: Walk	0.4	0.5	2.3	0.5	0.8	-0.9	0.7	0.3	0.1	0.5	-0.1	0.4	0.5	0.1	1.5
Eye problems/disorders: Cataract	0.8	0.9	2.0	0.8	0.1	1.4	-0.3	-0.1	1.3	0.3	1.3	1.2	-0.2	1.4	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.7	0.4	0.1	-0.8	1.1	1.3	-0.2	0.7	-0.1	-0.2	-0.3	-0.3	-0.6
Medication for cholesterol	0.2	0.3	2.0	-0.2	-0.7	-0.4	-0.1	-0.3	-0.3	-0.2	-0.3	-0.2	0.3	-0.3	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.5	2.6	1.5	0.5	-0.9	1.6	1.5	1.2	1.6	1.4	0.9	1.1	1.1	0.3
Back pain experienced in last month	0.8	1.2	2.5	1.6	1.2	-0.0	1.3	1.1	1.1	1.4	1.2	1.0	0.6	1.1	0.1
Mineral and other dietary supplements	0.2	0.2	0.7	0.0	-0.8	0.1	0.1	-0.2	0.6	0.3	0.7	0.6	0.5	0.7	-0.5
Breast cancer (self-reported)	1.0	1.2	4.3	-0.8	-1.1	-2.1	1.0	0.9	-1.1	0.3	-1.1	-1.2	1.2	-1.0	0.5
Asthma (self-reported)	1.0	2.1	4.5	1.3	-0.0	1.9	-0.8	-1.0	2.1	0.2	1.8	2.0	-0.9	2.1	-0.9
Osteoporosis (self-reported)	1.5	1.9	7.4	1.3	2.7	-0.9	1.5	0.9	0.5	1.3	0.5	0.7	0.7	0.5	2.4
Osteoarthritis (self-reported)	1.3	1.7	5.0	0.4	-1.3	2.2	-1.3	-1.6	1.3	-0.4	1.0	1.2	-0.7	1.4	-1.5
Medication: Aspirin	0.2	0.2	1.3	0.3	0.0	-0.4	0.6	0.5	-0.4	0.1	-0.4	-0.0	-0.2	-0.4	1.1
Medication: Gliclazide	5.0	5.7	13.0	3.6	1.9	1.8	1.3	0.8	3.1	2.4	3.1	3.1	0.2	3.2	1.2
Illnesses of father: None of the above (group 1)	1.0	1.3	3.6	0.9	0.4	-0.4	1.5	1.3	1.0	1.6	1.1	0.6	1.9	1.1	0.5
Smoking status: Current	2.9	4.6	8.5	2.3	2.6	-0.2	2.0	1.4	2.0	2.3	2.1	1.9	2.8	1.9	2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.3	-0.3	-1.0	1.0	-1.0	-1.2	-0.2	-0.7	-0.4	-0.2	-0.4	-0.1	-0.5
Whole body water mass	0.6	3.3	9.7	-0.1	-0.5	2.2	-2.9	-2.9	0.8	-1.9	0.3	0.9	-1.5	0.8	-3.1
Leg predicted mass (right)	0.9	4.8	13.3	-0.5	-0.6	2.7	-3.6	-3.6	0.8	-2.6	0.3	1.0	-1.7	0.8	-3.3
Arm fat mass (left)	2.4	10.0	27.1	-0.9	-1.4	4.8	-5.2	-4.3	1.2	-3.6	0.6	1.2	-4.1	1.1	-3.9
Number of self-reported non-cancer illnesses	0.5	0.8	2.1	1.4	0.8	1.4	0.2	0.7	1.0	0.5	0.9	1.1	-0.5	1.0	0.5
Average weekly champagne plus white wine intake	0.2	0.2	0.7	0.2	0.3	0.9	-0.8	-0.7	0.1	-0.6	-0.1	0.1	-0.4	0.2	0.3
Miserableness	0.2	0.3	0.6	0.5	0.4	0.0	0.5	0.4	0.6	0.7	0.8	0.7	0.4	0.5	-0.8
Guilty feelings	0.5	0.7	1.4	1.0	0.9	0.5	0.4	0.1	1.2	0.9	1.2	1.1	0.6	1.1	-0.1
Wears glasses or contact lenses	0.7	0.8	2.7	-0.4	-1.0	1.0	-1.4	-1.0	-0.1	-1.2	-0.2	-0.1	-1.6	-0.1	-0.7
Ever taken oral contraceptive pill	1.2	1.3	3.2	-0.3	1.6	1.8	-1.2	-1.7	1.1	-0.5	0.9	1.2	0.2	1.0	0.6
Hearing aid user	0.9	1.1	3.9	-0.4	0.3	-2.0	1.4	1.7	-0.8	0.7	-0.4	-0.9	1.1	-0.8	-0.0
Mother’s age at death	0.8	1.0	2.9	0.3	1.1	-1.4	1.4	1.2	-0.6	0.8	-0.4	-0.5	0.9	-0.6	1.7
Financial situation satisfaction	0.7	0.8	2.7	1.1	-1.6	-0.1	0.3	0.6	1.1	0.6	1.1	1.2	0.1	1.1	-0.4
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.8	0.8	0.0	-0.7	0.8	0.8	0.6	0.9	0.5	0.7	0.5	0.6	-0.0
Commuting to job workplace: Public transport	1.1	1.4	2.7	-0.7	-1.6	0.9	-1.6	-1.5	-0.6	-1.4	-0.7	-0.5	-1.1	-0.7	-1.6
Eye problems/disorders: Glaucoma	0.3	0.4	1.8	-0.1	-0.0	-1.0	1.0	0.3	-0.3	0.7	-0.1	-0.2	1.3	-0.4	-0.4
Medication: Blood pressure	0.3	0.6	2.4	-0.1	0.4	1.6	-1.0	-0.8	0.1	-0.9	-0.1	0.0	-1.4	0.1	0.0
Pain type(s) experienced in last month: Hip pain	1.1	1.3	2.6	1.6	-0.4	-0.4	1.0	0.5	1.5	1.5	1.6	1.4	-0.1	1.6	0.5
Supplements: Fish oil (including cod liver oil)	0.3	0.3	1.1	1.1	0.8	-0.1	0.6	0.9	0.2	0.7	0.1	0.1	0.1	0.2	0.7
High cholesterol (Self-reported)	0.8	1.5	5.4	0.3	0.1	-1.8	1.6	1.8	-0.9	0.9	-0.8	-0.7	0.0	-0.8	2.3
Medication: Bendroflumethiazide	0.3	0.4	2.8	0.6	0.5	0.3	0.3	0.7	0.3	0.3	0.0	0.6	-0.4	0.2	1.7
Medication: Paracetamol	1.1	1.7	4.5	1.0	0.5	1.1	0.1	-0.3	2.1	1.0	2.0	2.1	0.2	2.0	-0.7
Medication: Lisinopril	1.5	1.9	4.4	1.8	1.3	0.3	1.5	0.9	1.3	1.7	1.4	1.4	0.2	1.4	2.1
Medication: Atorvastatin	0.3	0.3	0.9	0.7	0.4	0.3	0.8	0.9	0.3	0.7	0.3	0.5	-0.6	0.2	0.6
Illnesses of father: High blood pressure	0.6	0.7	1.5	-0.9	1.2	0.1	-0.6	-0.5	-0.9	-0.7	-1.0	-0.8	-0.8	-1.0	0.9
Alcohol drinker status: Never	0.2	0.2	0.7	-0.4	-0.4	0.8	-0.5	-0.4	0.2	-0.4	0.1	0.3	-0.7	0.0	0.5
Ever smoked	0.6	1.0	6.1	0.5	1.2	-0.7	0.9	0.5	0.8	1.0	0.7	0.9	-0.2	0.7	2.5
Basal metabolic rate	0.9	5.1	13.3	-0.3	-0.8	2.9	-3.6	-3.5	0.9	-2.5	0.4	1.1	-2.2	0.9	-3.5
Leg fat percentage (left)	2.3	8.3	22.1	-0.6	-2.0	4.7	-4.3	-3.4	1.3	-2.9	0.8	1.4	-4.1	1.1	-3.4
Arm fat-free mass (left)	0.7	3.6	10.1	0.1	-0.9	2.5	-2.9	-2.9	1.1	-1.8	0.5	1.2	-1.7	1.0	-3.2
Number of operations (self-reported)	0.3	0.4	1.8	-0.3	1.1	0.5	-0.4	0.1	0.4	-0.3	0.2	0.4	-1.4	0.3	1.0
Average weekly beer plus cider intake	0.4	0.6	1.2	0.8	-0.6	0.9	-0.2	-1.1	0.9	0.4	0.9	0.8	0.6	1.0	-0.4
Irritability	0.5	0.8	2.5	-0.6	0.1	-1.6	0.5	0.9	-1.2	-0.2	-1.2	-1.0	-0.2	-1.2	0.0
Risk taking	0.3	0.4	1.2	-0.1	1.1	-1.0	0.6	0.7	-0.3	0.4	-0.2	-0.2	0.4	-0.2	1.0
Ever had prostate specific antigen (PSA) test	0.5	0.5	2.0	-0.7	-0.4	-1.4	0.7	0.4	-0.8	0.0	-0.7	-0.6	-0.3	-1.0	0.8
Fractured/broken bones in last 5 years	1.7	2.2	4.8	2.0	1.5	0.4	1.8	0.4	1.3	1.9	1.3	1.3	2.2	1.2	1.3
Age started oral contraceptive pill	0.2	0.2	1.6	-0.1	0.3	-0.4	0.6	0.4	-0.3	0.3	-0.3	-0.3	1.2	-0.3	0.3
Diastolic blood pressure, automated reading	0.4	1.2	6.2	1.0	-0.0	2.5	-0.4	-0.4	1.3	0.3	1.2	1.1	-0.0	1.4	0.1
Ever depressed for a whole week	0.3	0.4	0.8	0.4	-0.5	-0.0	0.2	0.7	0.9	0.5	0.9	0.9	-0.7	0.8	-0.3
Unable to work because of sickness or disability	0.9	1.2	2.2	1.4	1.5	0.2	1.1	0.5	1.1	1.3	1.2	1.0	1.1	1.1	0.7
Commuting to job workplace: Cycle	0.2	0.2	0.5	0.7	-0.1	0.2	0.4	-0.7	0.5	0.5	0.4	0.6	-0.1	0.5	-0.1
Myopia	1.0	1.5	3.0	-1.4	-1.0	-0.5	-0.4	-0.3	-1.7	-1.1	-1.6	-1.7	-1.2	-1.7	-0.5
Vascular/heart problems diagnosed by doctor	0.3	0.9	3.3	-1.3	-0.7	-1.8	0.1	0.1	-0.9	-0.2	-0.8	-1.1	0.7	-0.9	-0.8
Cholesterol lowering medication	0.3	0.4	1.8	-0.1	-0.1	-0.8	0.5	-0.0	-0.7	0.1	-0.7	-0.5	0.5	-0.7	1.3
Medication: Omeprazole (e.g. Zanprol)	2.0	2.4	5.8	2.4	0.8	0.9	0.9	0.7	1.9	1.6	1.9	2.0	1.3	1.8	1.0
Pain experienced in last month	4.2	7.1	14.5	-3.5	-1.1	-2.5	-1.0	-0.5	-3.8	-2.4	-3.8	-3.8	-1.0	-3.7	-0.5
Supplements: Calcium	0.7	0.8	4.0	-0.1	2.0	-0.3	0.7	0.7	-0.4	0.2	-0.5	-0.0	0.1	-0.5	1.9
Basal cell carcinoma (self-reported)	1.9	2.2	9.4	1.2	1.0	-1.5	2.1	1.8	0.5	1.7	0.6	0.9	0.8	0.5	3.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.6	-0.1	0.5	-0.6	0.7	0.8	-0.5	0.3	-0.5	-0.4	-0.9	-0.4	1.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.9	0.8	1.4	-0.8	0.9	1.2	-0.2	0.6	0.0	-0.4	1.0	-0.1	0.5
Heart disease (siblings)	0.5	0.7	2.5	0.5	-0.1	1.5	-0.9	-0.8	0.6	-0.3	0.4	0.8	-1.6	0.6	-0.1
Alcohol drinker status: Previous	1.1	1.3	2.9	1.4	0.4	0.8	0.5	0.6	1.6	1.0	1.7	1.5	0.3	1.6	0.1
Pack years of smoking	0.1	0.1	0.5	0.2	-0.7	0.0	0.1	0.6	0.1	0.1	-0.1	0.1	-0.1	0.1	-0.4
Impedance of whole body	0.2	0.9	3.0	0.5	-0.0	-0.8	1.6	1.6	0.1	1.3	0.2	0.3	0.5	0.1	1.7
Leg fat mass (left)	2.4	9.3	22.5	-0.6	-1.9	4.7	-4.7	-4.0	1.4	-3.2	0.8	1.5	-4.0	1.3	-3.8
Arm predicted mass (left)	0.7	3.5	8.8	0.1	-0.9	2.5	-2.8	-2.8	1.0	-1.8	0.5	1.1	-1.9	0.9	-3.0