Hub : Genes

DMXL2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.053 0.0230 0.00450 0.041 0.004 0.017 0.008 0.012 7.9e-06 0.088 2.9e-03 0.03 9.9e-03
2 GTEx Artery Tibial 0.087 0.0372 0.00370 0.102 NA 0.075 NA 0.093 2.2e-08 NA 1.7e-06 NA 9.0e-08
3 GTEx Cells EBV-transformed lymphocytes 0.167 0.0760 0.00043 0.130 NA 0.013 NA 0.063 5.2e-05 NA 1.1e-01 NA 4.2e-03
4 GTEx Cells Transformed fibroblasts 0.063 0.0300 0.00940 0.058 NA 0.054 NA 0.055 3.7e-05 NA 7.1e-05 NA 5.9e-05
5 GTEx Esophagus Mucosa 0.094 0.0440 0.00390 0.012 NA 0.002 NA 0.004 4.9e-02 NA 2.3e-01 NA 1.7e-01
6 GTEx Esophagus Muscularis 0.130 0.0470 0.00055 0.075 NA 0.076 NA 0.073 2.6e-05 NA 2.2e-05 NA 3.4e-05
7 GTEx Muscle Skeletal 0.125 0.0425 0.00011 0.043 NA 0.021 NA 0.032 4.6e-05 NA 3.7e-03 NA 3.8e-04
8 GTEx Nerve Tibial 0.343 0.0578 0.00000 0.301 NA 0.306 NA 0.308 1.3e-21 NA 4.5e-22 NA 3.0e-22
9 GTEx Pituitary 0.236 0.0890 0.00240 0.193 NA 0.133 NA 0.146 1.4e-05 NA 3.3e-04 NA 1.7e-04
10 TCGA Kidney Renal Papillary Cell Carcinoma 0.174 0.1070 0.00540 0.009 0.023 0.029 NA 0.024 9.5e-02 0.017 9.0e-03 NA 1.4e-02
11 TCGA Pheochromocytoma and Paraganglioma 0.121 0.0760 0.00320 0.047 0.032 0.059 NA 0.056 5.8e-03 0.020 2.2e-03 NA 2.8e-03
12 TCGA Uterine Corpus Endometrial Carcinoma 0.416 0.1850 0.00980 -0.006 0.025 0.039 NA 0.017 5.0e-01 0.067 3.0e-02 NA 1.0e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bipolar Disorder (2018) 1.1 1.7 3.2 -1.3 -1.8 -1.1 -0.7 -0.1 -1.7 -1.0 -1.7 -1.8 -0.5 -1.5 -1.2
Bipolar Disorder or Schizophrenia 2.1 5.1 9.3 -2.2 -2.9 -2.9 -0.3 0.4 -2.9 -1.4 -2.8 -3.0 0.0 -2.8 -1.9
Depressed Affect (Nagel 2018) 1.0 2.0 4.6 1.4 0.2 1.2 -0.2 -0.6 2.2 0.8 2.1 2.1 -0.0 2.0 -1.5
Depression (Nagel 2018) 0.6 0.9 2.6 0.8 -0.6 0.7 -0.4 -0.4 1.3 0.3 1.3 1.0 -0.5 1.3 -1.6
Intelligence (Savage-Jansen 2018) 3.1 9.5 30.5 -2.2 -2.2 3.3 -5.5 -4.6 -0.1 -4.5 -0.5 -0.1 -4.4 -0.0 -0.7
Neuroticism (Nagel 2018) 0.3 0.7 1.4 1.0 -0.0 -0.2 0.5 0.3 1.0 0.8 1.1 1.0 -0.3 1.0 -1.2
Schizophrenia (2018) 1.7 3.6 8.6 -1.8 -2.3 -2.9 0.2 0.6 -2.4 -0.9 -2.2 -2.5 0.4 -2.4 -1.5
Schizophrenia vs Biploar Disorder 1.7 2.2 6.3 1.3 0.4 -2.0 2.5 1.9 0.7 2.1 1.0 0.8 1.6 0.5 1.1
Worry (Nagel 2018) 0.6 1.2 3.2 1.8 0.9 0.1 0.8 1.1 1.3 1.2 1.2 1.3 -0.4 1.3 0.7
Alzheimer’s Disease (in mother) 0.4 0.5 2.8 0.1 -0.7 1.1 -0.2 0.2 0.5 0.0 0.5 0.6 -1.7 0.6 -0.3
Alzheimer’s Disease (in father) 1.2 1.3 5.5 -0.4 -0.8 2.1 -1.5 -1.2 0.4 -1.1 0.2 0.5 -2.3 0.3 -0.2
Alzheimer’s Disease (including proxy) 1.6 2.3 10.6 -0.8 -1.3 2.2 -1.9 -1.6 0.2 -1.4 0.0 0.3 -3.3 0.2 -0.9
Crohns Disease (2017) 0.3 0.6 1.8 -0.8 -0.6 0.8 -1.3 -1.3 -0.1 -1.1 -0.1 -0.2 -0.6 -0.1 -0.9
Irritable Bowel Disease (IBD) 0.2 0.4 1.2 -0.3 -1.0 0.9 -0.7 -1.0 0.1 -0.7 0.0 -0.1 0.3 0.0 -1.1
Ulcerative Colitis (UC) 0.3 0.5 1.7 0.9 -0.8 0.6 0.6 -0.1 0.6 0.6 0.6 0.4 1.3 0.6 -0.7
Major Depression (MDD) 0.4 0.5 1.0 0.5 0.4 0.9 -0.5 -0.1 0.9 0.1 0.9 1.0 -1.0 0.8 -0.4
Reaction Time 0.7 1.2 2.5 1.1 1.6 0.8 0.9 0.2 1.1 1.2 1.1 1.3 1.2 0.9 1.3
Verbal and Numeric Reasoning (VNR) 3.0 7.1 21.1 -1.4 -2.2 3.7 -4.6 -4.2 0.6 -3.5 0.5 0.3 -3.2 0.7 -1.4
Breast Cancer 2.0 4.7 9.9 -2.3 -1.4 1.7 -3.0 -2.9 -1.8 -3.1 -2.1 -1.8 -1.9 -1.6 -1.7
Ovarian Cancer 0.4 0.6 1.6 1.2 0.8 0.4 0.7 0.0 0.6 0.7 0.7 0.7 1.2 0.6 0.7
Prostate Cancer 0.9 1.2 7.2 0.8 1.1 -0.0 0.9 -0.4 0.9 1.1 1.0 0.9 2.7 0.8 0.7
Age at First Birth 1.1 1.5 3.8 -1.0 -0.4 -0.9 -0.4 0.3 -1.9 -1.2 -1.9 -1.7 -1.1 -1.8 0.4
Bipolar Disorder (2011) 0.3 0.3 1.1 -0.2 -1.0 -0.6 0.0 0.2 -0.5 -0.1 -0.4 -0.7 0.2 -0.5 -0.7
Body Mass Index (BMI) (2010) 3.1 4.2 13.8 0.4 -0.8 3.7 -2.7 -3.3 1.7 -1.3 1.4 1.8 -0.7 1.6 -2.3
Coronary Artery Disease (CAD) 0.3 0.3 1.1 -0.1 0.3 -0.1 0.2 0.9 -0.5 0.1 -0.7 0.1 -0.8 -0.5 -1.0
Crohns Disease (2012) 0.7 1.1 4.0 0.0 -1.4 1.4 -1.3 -2.0 0.7 -0.8 0.5 0.6 -0.2 0.6 -1.3
Mean Putamen Volume 0.9 1.0 3.5 0.5 1.9 1.3 -0.8 -0.8 1.0 -0.0 1.0 1.0 0.3 1.0 1.0
Fasting Glucose 1.1 1.3 5.3 -0.5 -0.4 1.7 -1.7 -2.3 0.4 -1.3 0.2 0.3 -1.0 0.3 -1.1
HbA1C 0.6 0.7 5.6 -0.3 -2.4 -0.2 -0.6 -0.2 -0.6 -0.3 -0.5 -0.4 -0.3 -0.5 -1.0
HDL Cholesterol 0.2 0.3 2.1 0.1 1.5 0.7 -0.2 -0.6 0.1 -0.2 0.3 0.2 0.4 0.1 0.7
LDL Cholesterol 0.1 0.1 0.5 0.5 -0.7 0.2 -0.1 -0.2 0.2 -0.0 0.2 0.3 0.5 0.3 0.3
Lupus 0.8 1.2 3.7 -0.9 1.4 -1.9 0.7 1.6 -0.8 0.2 -0.8 -0.8 -0.4 -1.0 1.1
Neuroticism (2016) 0.8 1.2 3.1 -0.2 -0.5 1.8 -1.6 -1.7 0.5 -1.0 0.5 0.5 -1.6 0.5 -1.0
Primary Biliary Cirrhosis 1.2 1.8 3.2 1.8 -0.8 0.9 0.8 0.1 1.8 1.4 1.8 1.6 1.6 1.7 -0.3
Rheumatoid Arthritis 0.2 0.3 0.8 0.1 0.9 -0.4 0.5 0.4 -0.5 0.3 -0.5 -0.4 0.7 -0.6 0.4
Schizophrenia (2014) 1.5 3.2 8.4 -1.6 -2.0 -2.9 0.5 0.8 -2.2 -0.5 -2.0 -2.3 0.7 -2.2 -1.6
Triglycerides 3.4 5.6 13.3 2.8 -0.3 2.6 0.4 -0.5 3.4 1.9 3.1 3.3 -0.3 3.6 1.5
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.6 0.8 0.2 0.6 0.0 -0.2 0.7 0.1 0.8 0.4 -0.6 0.6 -0.3
Ulcerative Colitis 0.7 1.0 5.1 0.0 -2.3 0.5 -0.3 -0.8 -0.0 -0.3 -0.1 -0.3 1.2 -0.0 -2.2
Blood Eosinophil Count 0.5 4.1 16.7 -0.7 -0.1 4.1 -2.9 -2.9 1.4 -1.8 1.1 1.3 -2.0 1.5 -0.3
Blood Platelet Count 0.1 1.4 4.8 -0.2 -1.1 1.0 -1.2 -2.2 1.1 -0.5 1.0 1.3 -0.9 1.1 -1.6
Blood Red Count 0.2 1.8 4.1 0.8 2.0 2.0 0.1 0.3 1.5 0.8 1.5 1.6 -0.5 1.6 1.5
Blood White Count 0.9 6.6 18.7 -2.0 -1.3 3.9 -4.0 -3.1 0.3 -2.9 0.1 -0.5 -4.3 0.6 -2.3
Heel T-Score 0.9 7.5 17.1 -4.1 -3.4 -2.4 -3.1 -2.9 -1.9 -3.3 -2.0 -1.9 -0.3 -1.9 -3.5
BMI 2.7 15.4 39.8 -1.2 -2.3 6.2 -6.3 -5.9 1.8 -4.3 1.1 1.7 -4.4 1.7 -4.0
Height 0.0 0.4 1.4 0.1 0.2 -1.1 -0.4 -0.3 -0.4 -0.7 -0.7 0.2 -1.0 -0.4 -1.2
Waist Hip Ratio (WHR) 1.1 4.9 13.4 2.3 -0.3 3.7 0.1 0.9 2.6 1.1 2.5 2.7 -3.4 2.5 0.6
Systolic Blood Pressure 0.2 1.1 5.6 1.2 0.5 2.4 -0.9 -0.7 0.9 -0.2 0.8 0.8 -1.1 1.1 0.1
Smoking Status 1.8 4.2 12.1 1.2 2.3 -2.2 2.8 2.2 1.1 2.6 1.2 1.1 1.7 0.9 3.5
Allergy or Eczema 0.3 0.9 1.6 1.0 0.9 0.2 0.9 1.1 1.1 1.2 1.2 0.8 -0.1 1.3 0.5
Cardiovascular Disease 0.8 2.5 6.1 1.7 1.0 2.5 -0.1 -0.2 2.0 0.8 1.9 2.1 -1.5 2.0 1.2
Hypothyroidism (self reported) 0.5 1.2 3.4 -1.9 -0.6 -0.1 -1.1 0.2 -1.3 -1.3 -1.3 -1.3 -1.2 -1.2 -0.2
Respiratory disease 1.8 3.9 8.2 2.0 -1.0 2.5 -0.5 -1.0 2.9 0.9 2.7 2.7 0.1 2.8 -1.5
Type 2 Diabetes (T2D) (2018) 3.0 5.6 17.4 1.2 0.6 4.2 -2.2 -2.6 2.7 -0.8 2.5 2.5 -2.7 2.8 0.1
Lung FEV1/FVC ratio 0.4 2.2 4.2 -1.5 -1.1 2.0 -2.0 -1.6 -0.8 -2.0 -1.1 -0.9 -1.7 -0.8 -1.6
Lung FVC 0.2 0.9 4.5 0.3 0.2 2.1 -0.9 -1.5 0.9 -0.1 0.8 0.9 -0.1 0.8 0.4
Neuroticism 0.2 0.5 1.1 0.8 -0.3 0.5 -0.1 0.2 0.9 0.3 0.9 0.7 -1.1 0.9 -0.7
Chronotype (morning person) 1.1 2.6 6.3 1.9 -0.7 2.5 -0.3 -1.1 2.2 0.6 2.1 2.2 0.0 2.2 0.5
Hair Pigment 0.0 0.8 2.9 0.7 1.2 -1.1 0.8 0.4 0.7 1.0 0.7 0.7 1.7 0.6 0.1
Tanning 0.3 4.1 8.4 2.0 0.8 -1.0 2.7 2.7 1.9 2.9 2.0 2.0 1.8 1.9 1.8
Hand grip strength (left) 1.5 4.1 6.3 -2.1 -1.7 -1.0 -1.8 -1.6 -2.5 -2.4 -2.5 -2.4 -1.1 -2.4 -2.1
Number of treatments/medications taken 1.6 2.9 4.3 2.1 1.8 0.4 1.6 1.8 1.8 1.9 1.7 2.0 -0.1 1.7 2.0
Average weekly spirits intake 1.4 1.7 4.1 -1.6 0.7 -2.0 0.3 0.4 -1.7 -0.6 -1.7 -1.7 0.6 -1.8 0.7
Sensitivity / hurt feelings 0.9 1.6 6.5 -0.0 0.7 -2.5 1.9 1.5 -0.7 1.3 -0.5 -0.7 1.1 -0.7 1.2
Frequency of depressed mood in last 2 weeks 0.1 0.2 1.1 -0.2 -0.1 0.1 -0.8 -0.5 0.0 -0.6 -0.2 0.1 0.1 -0.2 -1.1
Hearing difficulty/problems: Yes 0.4 0.6 1.7 0.2 0.4 0.5 -0.7 -1.3 0.9 -0.3 0.9 0.8 -0.0 0.8 -0.9
Relative age of first facial hair 0.8 1.6 3.7 0.1 1.7 -1.4 1.8 1.9 -0.0 1.5 0.2 0.0 1.6 -0.1 1.4
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 2.5 -0.4 -0.6 1.6 -1.3 -1.1 0.5 -1.0 0.3 0.6 -1.4 0.5 -1.2
Ever used hormone-replacement therapy (HRT) 1.6 2.1 3.5 1.8 0.6 0.1 1.6 1.3 1.8 1.9 1.9 1.6 1.0 1.6 0.6
Ever had hysterectomy (womb removed) 2.2 2.5 5.0 1.5 1.6 1.3 0.3 -0.9 2.2 1.1 2.0 2.0 1.9 2.1 0.0
Systolic blood pressure, automated reading 0.1 0.3 1.3 1.0 -0.3 1.2 -0.2 0.3 0.4 0.2 0.5 0.2 -0.6 0.6 -0.0
Eye problems/disorders: Diabetes related eye disease 2.9 3.2 7.2 2.1 1.1 1.5 0.5 0.4 2.5 1.4 2.6 2.7 -0.1 2.6 1.1
Angina 0.3 0.4 1.3 0.3 0.2 -0.5 1.1 1.2 -0.5 0.5 -0.3 -0.4 -0.3 -0.5 0.7
Medication for hormone replacement therapy 0.2 0.2 0.8 0.2 -0.9 -0.0 -0.1 -0.1 0.5 0.2 0.5 0.1 0.6 0.5 -0.3
Vitamin and mineral supplements 0.2 0.3 0.8 -0.2 -0.3 -0.1 0.7 0.9 0.4 0.7 0.5 0.2 -0.9 0.4 0.5
Supplements: Zinc 0.7 0.8 2.3 0.1 0.4 1.5 -1.5 -1.1 0.2 -1.1 -0.1 0.4 -1.5 0.3 -0.1
Medication: Co-codamol 0.8 0.9 1.9 -0.7 1.2 -1.3 0.8 0.8 -1.3 0.1 -1.2 -1.1 0.4 -1.4 0.4
Medication: Metformin 1.3 1.9 4.2 1.5 1.5 2.0 -0.4 -1.1 1.7 0.3 1.8 1.5 -1.0 1.8 0.6
Diabetes (father) 0.2 0.3 1.1 0.0 -0.2 1.0 -1.1 -0.3 0.0 -0.8 -0.2 -0.2 -0.8 -0.0 -0.1
Diabetes (mother) 2.3 3.0 6.4 2.3 -0.4 1.8 -0.2 -0.6 2.5 1.0 2.5 2.4 1.0 2.5 -0.5
Severe depression (siblings) 1.2 1.4 5.8 -0.7 -1.4 0.8 -1.7 -1.6 0.1 -1.3 -0.2 -0.0 -0.5 0.1 -2.4
Pack years adult smoking proportion 0.1 0.1 0.7 -0.1 -0.8 -0.1 -0.2 0.3 -0.1 -0.1 -0.3 -0.0 -0.0 -0.1 -0.4
Impedance of leg (right) 0.4 1.8 5.0 1.3 -0.1 -0.5 2.2 2.1 0.6 2.1 0.7 0.7 0.5 0.7 2.0
Leg fat-free mass (left) 0.8 4.1 11.3 -0.2 -0.2 2.7 -3.4 -3.3 1.1 -2.2 0.6 1.1 -1.8 1.0 -2.8
Trunk fat percentage 2.7 10.8 27.4 -1.6 -2.3 4.7 -5.2 -4.0 0.6 -4.0 0.0 0.8 -5.1 0.5 -3.7
Hand grip strength (right) 0.6 1.7 3.6 -1.1 -1.4 0.2 -1.7 -1.4 -1.1 -1.7 -1.3 -0.9 -1.1 -1.0 -1.9
Townsend deprivation index at recruitment 2.2 3.2 5.7 1.8 1.8 1.3 0.8 -0.1 2.3 1.7 2.4 2.3 1.7 2.4 1.1
Current tobacco smoking 3.3 5.4 11.1 2.3 2.8 -0.9 2.5 1.8 1.7 2.6 1.8 1.7 3.3 1.7 3.3
Average weekly fortified wine intake 0.8 1.0 2.8 -1.0 -1.7 -1.4 -0.0 0.4 -1.1 -0.6 -1.0 -1.2 0.8 -1.0 0.1
Maternal smoking around birth 1.7 2.4 5.5 1.9 1.0 1.7 -0.1 -0.7 2.3 0.8 2.3 2.3 0.1 2.1 -0.4
Fed-up feelings 2.4 4.4 9.4 1.5 1.3 2.7 -1.3 -1.4 3.1 0.4 2.9 3.0 -0.1 2.9 -1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.4 1.9 4.9 1.3 0.0 2.2 -1.2 -1.2 1.8 -0.1 1.4 1.7 -0.9 1.8 -0.8
Relative age voice broke 0.7 1.0 2.5 -0.5 0.2 -1.6 1.2 1.5 -1.1 0.3 -1.0 -0.9 0.6 -1.2 0.8
Taking other prescription medications 0.6 0.9 1.7 1.3 0.8 0.6 0.7 1.3 1.1 0.9 1.0 1.3 0.0 1.0 0.3
Age when periods started (menarche) 0.3 0.8 2.0 0.9 0.9 -0.1 1.2 0.1 0.8 1.2 0.9 1.0 1.4 0.8 0.3
Bilateral oophorectomy (both ovaries removed) 3.5 4.0 6.9 2.6 1.5 0.0 2.0 1.8 2.3 2.6 2.4 2.1 2.0 2.2 0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.9 1.9 5.5 -0.8 -1.8 0.8 -2.2 -2.4 0.8 -1.5 0.8 0.8 -0.5 0.8 -1.8
Tinnitus: Yes, but not now, but have in the past 0.9 0.9 2.6 1.3 0.6 0.3 0.6 -0.1 1.2 1.1 1.4 0.8 1.6 1.1 0.0
Qualifications: CSEs or equivalent 0.5 0.6 1.5 0.6 0.2 0.4 0.7 0.2 0.9 1.2 1.0 0.8 1.2 0.8 -0.2
Serious illness, injury or assault to yourself 0.4 0.5 2.7 -0.3 1.6 -0.5 0.5 0.4 -0.4 0.2 -0.4 -0.4 0.8 -0.3 0.9
High blood pressure 0.3 1.0 3.0 1.3 1.2 1.7 0.0 0.1 1.0 0.4 0.9 1.1 -0.5 1.0 0.9
Hayfever, allergic rhinitis or eczema 0.1 0.1 0.5 -0.0 0.4 0.5 -0.1 0.3 0.4 -0.0 0.4 0.2 -0.7 0.5 0.2
Multivitamins +/- minerals 0.2 0.3 1.6 0.4 0.4 -0.5 0.1 -0.1 -0.6 -0.2 -0.7 -0.4 1.3 -0.6 -0.0
Stomach or abdominal pain in last month 2.4 3.0 7.6 1.8 1.3 2.8 -0.4 -1.2 2.3 0.7 2.3 2.1 0.3 2.2 -0.8
Supplements: Glucosamine 0.3 0.4 0.8 -0.8 0.4 0.6 -0.8 -0.6 -0.4 -0.9 -0.6 -0.2 -0.9 -0.5 -0.2
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 3.4 -0.8 -0.5 1.4 -1.7 -1.8 -0.5 -1.5 -0.7 -0.4 0.2 -0.6 -1.6
Medication: Atenolol 3.1 3.9 8.6 -2.1 -1.3 -1.6 -0.5 0.3 -2.9 -1.8 -2.7 -2.8 -1.4 -2.9 -0.6
Medication: Levothyroxine sodium 1.0 1.8 3.5 -1.6 -0.6 -1.8 0.4 0.9 -1.8 -0.4 -1.8 -1.7 0.5 -1.9 0.6
Sitting height 0.3 1.9 9.9 0.5 -0.4 -3.1 1.9 1.9 -0.4 1.3 -0.5 -0.4 1.3 -0.4 -0.9
Chronic bronchitis/emphysema (father) 0.7 0.8 1.9 1.1 -0.1 0.9 0.1 -0.5 1.3 0.6 1.1 1.4 1.0 1.3 0.1
High blood pressure (mother) 1.0 1.4 2.5 -1.3 1.0 0.1 -1.0 -1.5 -1.4 -1.6 -1.6 -1.1 -0.0 -1.6 0.2
Body mass index (BMI) 1.9 8.1 21.8 -1.2 -1.4 4.2 -4.7 -3.9 0.7 -3.4 0.2 0.7 -3.8 0.6 -3.3
Impedance of leg (left) 0.2 0.9 2.6 0.9 -1.2 -0.4 1.6 1.5 0.3 1.5 0.4 0.4 0.4 0.3 0.9
Leg predicted mass (left) 0.8 4.1 11.3 -0.2 -0.1 2.7 -3.4 -3.3 1.1 -2.2 0.6 1.2 -1.8 1.0 -2.8
Trunk fat mass 2.5 10.9 28.1 -1.4 -2.0 4.6 -5.3 -4.1 0.8 -4.0 0.1 1.0 -5.0 0.6 -4.0
Waist circumference 2.9 10.6 27.8 -0.5 -1.9 5.3 -4.8 -4.0 1.7 -3.2 1.1 1.8 -5.0 1.5 -3.5
Number of incorrect matches in round 3.4 5.6 16.1 1.2 1.8 -3.2 4.0 3.9 -0.1 2.9 0.2 0.1 2.7 -0.3 2.3
Past tobacco smoking 0.7 1.2 3.4 -0.6 -0.8 1.1 -1.3 -0.8 -1.1 -1.4 -1.0 -1.2 0.3 -0.8 -1.8
Alcohol usually taken with meals 0.2 0.4 1.8 -0.4 -1.3 0.1 -0.4 -0.4 -0.6 -0.6 -0.8 -0.7 -0.0 -0.6 -0.2
Nervous feelings 0.3 0.6 1.9 0.7 1.4 -0.3 0.7 0.9 0.7 0.9 0.7 0.7 0.3 0.6 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 1.1 0.2 0.4 0.5 -1.1 -0.9 0.4 -0.7 0.1 0.3 0.2 0.3 -0.3
Hearing difficulty/problems with background noise 0.5 0.9 4.4 0.5 1.1 -1.3 1.1 0.3 0.3 0.9 0.4 0.3 2.1 0.2 0.4
Hair/balding pattern: Pattern 2 0.5 0.7 2.8 0.2 -1.4 0.9 -0.7 -1.3 0.4 -0.3 0.1 0.5 0.3 0.3 -1.7
Had menopause 0.6 0.7 1.7 1.1 0.3 0.2 1.1 1.3 0.9 1.0 0.9 0.8 -0.0 0.8 0.5
Had other major operations 1.0 1.2 2.8 -0.8 -1.0 1.1 -1.6 -1.2 -0.5 -1.7 -0.6 -0.5 -1.6 -0.4 -1.1
Forced vital capacity (FVC) 0.5 1.8 6.2 0.2 -0.8 2.2 -1.9 -2.5 0.8 -0.9 0.5 0.8 -0.5 0.8 -1.7
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 3.9 -0.4 -1.2 0.4 -1.6 -2.0 0.9 -1.0 0.8 0.8 0.3 0.8 -1.2
Ever unenthusiastic/disinterested for a whole week 1.6 2.0 3.8 1.7 1.2 0.4 1.1 0.8 1.9 1.5 1.9 1.9 0.5 1.8 0.7
Qualifications: None of the above 0.7 1.5 3.6 1.5 0.1 -0.8 1.9 1.3 0.9 1.8 1.0 0.8 1.8 0.9 -0.0
Financial difficulties in last 2 years 0.2 0.2 1.1 -0.4 0.3 -0.9 -0.3 -0.1 -0.2 -0.3 -0.2 -0.0 0.1 -0.3 1.1
Mouth/teeth dental problems 0.2 0.3 1.9 0.3 0.1 0.4 0.0 0.1 0.7 0.5 0.6 0.6 0.1 0.7 1.4
Heart attack 0.5 0.6 2.6 0.1 0.5 -0.8 0.9 1.0 -0.4 0.5 -0.3 -0.3 -1.0 -0.2 1.6
Allergy 0.4 0.9 2.1 -1.1 -0.6 -0.9 -0.3 -0.2 -1.4 -0.7 -1.3 -1.3 0.5 -1.4 -0.2
Pain all over the body in last month 1.4 1.5 3.4 1.7 0.2 0.4 0.6 0.1 1.8 1.3 1.8 1.7 0.4 1.6 0.3
Diabetes (self-reported) 1.3 2.1 5.9 0.7 2.4 1.8 -1.0 -1.3 1.3 -0.4 1.2 1.3 -1.7 1.3 1.8
Hayfever/allergic rhinitis (self-reported) 0.8 1.0 2.4 -1.3 -0.6 0.7 -1.3 -0.8 -0.7 -1.3 -0.7 -0.8 -1.5 -0.6 -1.2
Medication: Ramipril 0.5 0.6 1.9 0.5 1.3 1.3 -0.4 0.5 0.2 -0.1 -0.0 0.5 -1.2 0.3 1.4
Medication: Simvastatin 1.0 1.5 9.1 0.6 1.4 -1.1 1.5 1.2 -0.3 1.0 -0.2 0.1 0.8 -0.2 3.0
Fluid intelligence score 1.9 3.9 11.1 -1.9 -1.9 1.6 -3.3 -2.6 -0.6 -2.9 -0.6 -0.7 -2.7 -0.6 -1.1
Illnesses of siblings 0.4 0.5 1.8 0.7 0.1 -0.6 0.9 1.1 0.4 0.9 0.5 0.4 1.4 0.4 0.3
Neuroticism score 0.6 1.2 2.6 1.2 0.8 0.5 0.4 0.6 1.6 1.1 1.6 1.5 -0.2 1.6 0.1
Weight 1.8 8.8 23.9 -1.1 -1.4 3.9 -4.9 -4.2 0.8 -3.6 0.1 0.9 -3.8 0.6 -4.0
Impedance of arm (right) 0.0 0.1 0.7 -0.0 0.3 0.2 0.2 0.2 0.1 0.1 0.1 0.2 -0.3 0.1 0.8
Arm fat percentage (right) 3.0 11.8 31.2 -0.9 -1.3 5.6 -5.5 -4.6 1.4 -3.8 0.8 1.4 -4.5 1.3 -3.8
Trunk fat-free mass 0.4 2.3 8.1 0.0 -0.4 1.6 -2.4 -2.5 0.5 -1.7 0.1 0.6 -1.2 0.5 -2.8
Hip circumference 1.6 7.0 20.0 -1.4 -1.6 3.1 -4.5 -4.0 0.5 -3.3 -0.0 0.6 -3.1 0.5 -3.5
Time employed in main current job 2.3 2.7 7.1 1.6 2.4 -1.3 2.3 2.1 0.4 1.9 0.4 0.5 1.1 0.5 2.7
Alcohol intake versus 10 years previously 0.2 0.4 1.1 -0.9 -0.2 -0.1 -0.2 -0.1 -0.7 -0.5 -0.6 -0.8 -0.1 -0.8 -1.1
Father’s age at death 1.7 2.2 5.2 -1.5 -2.2 1.4 -2.3 -2.0 -0.5 -2.1 -0.6 -0.5 -1.0 -0.6 -1.4
Worrier / anxious feelings 0.1 0.2 1.0 0.1 0.3 -0.2 -0.1 0.5 -0.3 -0.1 -0.3 -0.3 -1.0 -0.1 0.4
Frequency of tiredness / lethargy in last 2 weeks 4.6 7.4 21.4 0.2 -0.7 4.5 -4.0 -4.6 2.0 -2.3 1.5 2.0 -2.1 2.0 -2.7
Falls in the last year 1.8 2.5 8.3 1.2 2.9 -0.8 1.8 1.2 0.9 1.8 1.1 0.7 2.1 0.8 1.8
Hair/balding pattern: Pattern 3 0.1 0.2 0.6 0.3 0.2 0.1 0.3 -0.1 0.7 0.5 0.8 0.6 0.2 0.7 0.4
Number of live births 0.2 0.3 0.8 0.9 0.9 -0.3 0.9 0.8 0.2 0.7 0.3 0.2 -0.1 0.2 0.0
Forced expiratory volume in 1-second (FEV1) 0.8 2.6 7.8 -0.1 -1.6 2.7 -2.3 -2.8 0.7 -1.3 0.3 0.7 -0.8 0.8 -2.2
Pulse rate 3.8 6.3 11.0 2.9 2.0 1.3 1.7 0.3 3.3 2.8 3.3 3.0 2.4 3.3 1.9
Happiness 1.6 2.0 4.5 -0.2 -1.4 2.0 -2.1 -1.8 0.5 -1.4 0.3 0.6 -1.9 0.5 -2.1
Noisy workplace 1.2 1.5 5.1 0.2 1.4 2.3 -1.7 -1.7 1.0 -0.9 0.8 1.2 -0.7 1.0 0.3
Qualifications: A levels/AS levels or equivalent 4.4 9.7 17.5 -4.1 -1.6 -2.1 -2.6 -1.3 -4.1 -3.7 -4.2 -3.8 -2.1 -4.1 -0.7
Serious illness, injury or assault of a close relative in last 2 years 1.5 1.7 6.1 1.4 1.2 0.5 0.5 -0.1 1.6 1.1 1.5 1.5 2.5 1.6 0.3
Mouth/teeth dental problems: Dentures 0.7 1.2 3.9 1.6 0.4 -0.9 1.7 1.1 0.5 1.4 0.6 0.5 2.0 0.4 -0.3
Asthma 1.1 2.1 4.4 1.2 -0.3 2.0 -1.0 -1.2 2.1 0.1 1.7 2.0 -0.6 2.1 -1.2
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.6 -0.2 0.1 -0.7 0.8 0.8 -0.1 0.4 0.0 -0.2 0.3 -0.1 0.6
Medication: Cholesterol lowering 2.3 3.5 10.3 1.8 1.5 -1.3 2.7 2.9 0.7 2.4 0.9 1.0 0.8 0.7 3.2
Depression (self-reported) 1.1 1.3 2.9 1.6 1.3 1.1 -0.3 -0.7 1.7 0.5 1.5 1.5 0.3 1.6 0.4
Medication: Lansoprazole 0.2 0.2 0.6 0.8 0.5 -0.3 0.5 0.6 0.2 0.6 0.1 0.2 0.3 0.2 0.2
Prospective memory result 0.5 0.7 2.0 0.5 0.7 -0.9 1.3 1.3 -0.0 1.0 0.0 -0.2 1.4 -0.0 0.1
Lung cancer (father) 3.4 4.0 7.8 2.7 1.0 1.4 1.0 0.4 2.7 2.1 2.8 2.6 1.6 2.7 0.5
Illnesses of mother 0.7 0.9 1.9 0.9 0.2 -0.6 1.3 1.2 0.7 1.4 0.8 0.9 0.4 0.9 1.3
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 3.9 11.1 -0.4 -2.2 2.9 -3.0 -3.3 0.6 -1.9 0.1 0.6 -0.9 0.6 -2.9
Pulse wave Arterial Stiffness index 0.7 0.8 6.1 -0.1 0.7 -0.3 0.8 1.0 0.0 0.4 -0.0 0.5 -0.7 0.1 2.5
Impedance of arm (left) 0.1 0.3 1.6 -0.1 0.6 -0.5 0.7 1.0 -0.1 0.6 0.0 0.1 0.2 -0.1 1.3
Arm fat mass (right) 2.7 11.0 28.8 -1.1 -1.6 4.9 -5.4 -4.5 1.1 -3.9 0.4 1.1 -4.4 0.9 -4.2
Trunk predicted mass 0.4 2.2 7.8 0.1 -0.5 1.5 -2.3 -2.4 0.5 -1.6 0.1 0.6 -1.1 0.5 -2.8
Standing height 0.1 0.6 3.6 0.1 -0.2 -0.1 -1.0 -0.9 0.1 -0.8 -0.4 0.5 -0.8 0.1 -1.9
Length of working week for main job 0.6 0.6 2.3 -0.2 0.9 -1.5 1.0 1.2 -0.4 0.6 -0.0 -0.5 0.8 -0.6 0.8
Exposure to tobacco smoke at home 2.7 3.1 6.1 -2.1 -2.1 0.6 -1.9 -1.6 -1.6 -2.1 -1.5 -1.7 -0.9 -1.6 -2.5
Breastfed as a baby 0.8 1.0 3.2 -1.8 -0.5 -0.6 -0.7 -0.3 -1.1 -1.1 -1.1 -1.0 -1.3 -1.1 -0.4
Tense / ‘highly strung’ 0.1 0.2 0.8 0.6 0.6 -0.0 0.5 0.9 -0.0 0.4 -0.2 0.1 -0.4 -0.1 0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.9 4.4 0.8 0.2 2.1 -1.5 -1.5 1.8 -0.3 1.5 1.8 -0.1 1.7 -1.2
Hair/balding pattern: Pattern 4 0.4 1.1 2.8 1.2 1.6 1.7 -0.4 -0.4 1.2 0.2 1.2 1.2 -0.1 1.2 0.1
Birth weight of first child 0.9 1.7 5.8 -0.6 -0.8 1.9 -2.1 -1.4 0.4 -1.6 0.1 0.5 -2.4 0.3 -0.6
Peak expiratory flow (PEF) 0.8 1.9 4.6 -1.2 -2.2 0.6 -1.9 -1.9 -0.8 -1.6 -1.0 -0.8 -1.5 -0.7 -1.4
Pulse wave reflection index 1.2 1.4 7.2 -1.3 -1.1 0.6 -1.4 -0.0 -0.9 -1.5 -1.0 -0.4 -2.7 -0.7 0.1
Ever highly irritable/argumentative for 2 days 0.2 0.2 1.1 -0.7 -0.3 -1.0 -0.1 -0.1 -0.5 -0.3 -0.6 -0.4 -0.0 -0.6 -0.2
Loud music exposure frequency 0.1 0.1 0.3 -0.1 0.3 0.3 0.1 0.3 0.4 0.1 0.5 0.6 -0.3 0.3 0.3
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 3.7 -1.7 0.0 -1.6 -0.1 0.4 -1.9 -0.9 -1.7 -1.8 -0.1 -1.9 0.2
Mouth/teeth dental problems: Bleeding gums 1.5 2.0 4.8 -1.6 -1.2 0.9 -2.2 -1.9 -0.8 -2.0 -0.8 -0.7 -1.7 -0.6 -1.4
Blood clot in the leg (DVT) 0.2 0.3 1.1 0.4 1.1 -0.6 0.4 0.7 -0.3 0.2 -0.1 -0.5 0.6 -0.2 0.3
Medication: Paracetamol 0.7 1.1 2.8 0.7 0.7 0.5 0.3 -0.1 1.6 1.0 1.5 1.7 1.0 1.5 -0.3
Headache pain in last month 0.6 1.0 4.1 -0.3 -0.3 1.6 -1.4 -1.2 0.4 -0.9 0.4 0.4 0.6 0.4 -2.0
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 5.5 -1.1 -1.3 0.3 -1.4 -1.5 -0.3 -1.2 -0.3 -0.7 -0.2 -0.2 -2.4
Glaucoma (self-reported) 0.2 0.3 0.5 0.5 0.7 0.1 0.6 0.1 0.6 0.7 0.6 0.7 0.4 0.5 0.3
Gout (self-reported) 0.9 1.2 3.3 -1.3 -1.8 -0.8 -0.0 0.6 -1.3 -0.6 -1.1 -1.3 -0.8 -1.4 -0.8
Hypothyroidism/myxoedema (self-reported) 1.0 2.0 4.6 -2.1 -0.5 -0.3 -1.2 0.0 -1.8 -1.7 -2.0 -1.7 -0.9 -1.8 -0.4
Medication: Amlodipine 0.2 0.3 1.4 0.4 0.7 1.2 -0.1 -0.4 0.4 0.1 0.2 0.7 0.6 0.3 0.7
Medication: Ventolin 100micrograms inhaler 2.6 3.3 11.8 0.1 -0.7 2.8 -2.2 -2.6 1.4 -1.1 1.1 1.1 -0.7 1.4 -3.4
Birth weight 1.3 2.8 5.5 -2.0 -1.5 0.6 -2.3 -1.9 -0.9 -2.1 -0.9 -1.0 -2.3 -1.0 -2.1
Chronic bronchitis/emphysema (mother) 0.9 1.1 2.0 1.3 1.4 0.1 0.5 0.5 1.4 1.1 1.4 1.3 0.4 1.3 -0.0
High blood pressure (siblings) 0.5 0.8 1.7 -1.0 -0.8 -0.9 -0.3 -0.2 -1.1 -0.6 -1.1 -1.3 -0.6 -1.1 -0.7
Forced vital capacity (FVC), Best measure 0.9 3.3 9.4 -0.0 -1.8 2.8 -2.7 -3.1 0.8 -1.6 0.3 0.9 -0.8 0.9 -2.5
Body fat percentage 2.7 10.7 26.8 -1.3 -2.2 4.9 -5.2 -4.0 0.9 -3.8 0.3 1.0 -4.9 0.8 -3.6
Leg fat percentage (right) 1.9 6.9 20.2 -0.4 -1.4 4.5 -3.9 -3.1 1.4 -2.5 0.9 1.4 -4.0 1.3 -2.7
Arm fat-free mass (right) 0.4 2.2 7.1 0.0 -0.7 1.7 -2.2 -2.1 0.7 -1.5 0.3 0.9 -1.4 0.7 -2.7
Exposure to tobacco smoke outside home 0.6 0.9 4.0 0.4 1.2 -1.0 0.9 0.7 0.3 1.0 0.5 0.4 2.0 0.2 1.0
Comparative body size at age 10 3.7 10.3 20.8 -3.9 -2.6 1.4 -4.2 -3.2 -2.6 -4.6 -2.9 -2.6 -3.5 -2.6 -3.1
Number of full brothers 0.4 0.5 2.2 -0.1 1.1 0.8 -0.8 -1.5 0.3 -0.4 0.0 0.4 -0.3 0.4 1.0
Worry too long after embarrassment 0.5 0.9 5.2 -0.2 -1.7 0.0 -0.9 -1.0 0.3 -0.6 0.4 0.1 -0.6 0.4 -2.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 3.5 0.8 0.9 -0.6 1.2 1.9 0.7 1.3 0.9 0.7 -0.2 0.6 0.6
Wheeze or whistling in the chest in last year 2.0 3.5 11.2 1.0 -1.1 3.4 -2.2 -2.2 1.7 -1.0 1.4 1.6 -2.1 1.8 -1.5
Number of children fathered 5.0 5.7 9.6 2.9 2.7 -0.3 2.5 2.0 2.5 3.1 2.6 2.3 1.4 2.5 2.3
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 1.0 0.0 0.2 -0.6 0.8 -0.2 -0.2 0.6 -0.2 0.1 0.6 -0.3 1.0
Age at first live birth 1.7 3.0 6.2 -1.4 -1.9 -2.1 0.7 1.1 -2.5 -0.6 -2.3 -2.3 -0.9 -2.4 -0.9
Pulse wave peak to peak time 0.7 0.8 6.2 0.1 -0.7 0.4 -0.9 -1.2 0.1 -0.5 0.1 -0.3 0.7 0.1 -2.5
Health satisfaction 1.2 1.6 4.7 0.1 0.1 2.2 -1.7 -1.1 1.3 -0.9 0.8 1.3 -1.7 1.2 -0.8
Shortness of breath walking on level ground 0.2 0.2 0.7 -0.8 0.6 0.0 -0.4 -0.3 -0.1 -0.5 -0.4 0.1 -0.8 -0.3 0.3
Qualifications: College or University degree 3.7 11.7 23.0 -3.8 -3.6 0.8 -4.5 -3.9 -3.0 -4.8 -3.2 -2.8 -3.4 -2.8 -2.7
Eye problems/disorders: None of the above 1.8 2.1 4.5 -1.7 -0.9 -1.1 -0.8 -0.2 -2.0 -1.5 -2.1 -2.0 -1.2 -2.0 -0.1
Mouth/teeth dental problems: Loose teeth 0.5 0.5 2.2 0.4 0.8 1.2 -0.1 0.3 0.7 0.0 0.7 0.7 -1.5 0.7 0.2
Emphysema/chronic bronchitis 0.4 0.4 1.4 -0.0 0.1 1.0 -0.5 -1.2 0.5 -0.3 0.5 0.4 0.8 0.3 -1.1
Medication for pain relief, constipation, heartburn 1.9 3.3 5.2 -2.1 -1.4 0.1 -1.8 -1.3 -2.2 -2.1 -2.3 -2.3 -1.5 -2.1 -1.3
Neck or shoulder pain in last month 5.5 7.8 13.0 3.6 1.6 0.4 2.7 2.7 3.3 3.6 3.5 3.2 1.2 3.3 1.7
Medication: Blood pressure 0.4 0.7 4.5 0.8 0.7 -0.1 1.0 1.0 0.1 0.8 0.2 0.5 0.0 0.0 2.1
Angina (self-reported) 0.2 0.3 0.9 0.4 0.2 -0.2 1.0 0.9 -0.4 0.4 -0.2 -0.3 -0.3 -0.4 0.6
Migraine (self-reported) 0.3 0.3 0.8 -0.9 -0.7 -0.9 -0.2 -0.5 -0.3 -0.4 -0.3 -0.6 0.5 -0.4 -0.6
Medication: Ibuprofen 0.4 0.5 1.4 0.5 0.1 0.1 0.7 0.3 1.0 0.8 1.2 1.0 -0.0 1.1 0.2
Medication: Allopurinol 0.2 0.2 1.1 0.0 -1.0 -0.5 0.5 0.9 -0.3 0.3 -0.2 -0.3 -0.1 -0.3 0.4
Medication: Omeprazole 2.6 3.1 6.1 2.5 0.8 0.5 1.4 1.1 2.1 2.0 2.2 2.2 1.3 2.0 1.7
Medication: Seretide 50 evohaler 0.4 0.4 2.4 0.2 -0.8 -1.0 0.8 0.4 -0.1 0.6 -0.1 -0.2 0.3 -0.1 -1.5
Mean time to correctly identify matches 0.6 1.2 3.0 1.0 1.7 0.6 1.1 0.7 0.8 1.1 0.8 1.0 1.2 0.6 1.7
Heart disease (mother) 0.3 0.4 1.8 -0.8 -0.1 -0.4 -0.5 -0.0 -0.6 -0.6 -0.6 -0.6 0.2 -0.8 -1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.9 2.2 8.4 0.5 0.9 -2.9 2.2 2.0 -0.7 1.4 -0.3 -0.8 1.7 -0.6 1.4
Whole body fat mass 2.5 10.5 27.0 -1.2 -2.0 4.6 -5.2 -4.2 0.9 -3.8 0.3 1.0 -4.6 0.8 -4.0
Leg fat mass (right) 2.3 8.9 22.1 -0.7 -1.5 4.7 -4.6 -3.9 1.4 -3.2 0.8 1.5 -4.2 1.2 -3.4
Arm predicted mass (right) 0.4 2.3 7.8 -0.1 -0.8 1.7 -2.3 -2.3 0.7 -1.5 0.2 0.8 -1.3 0.6 -2.8
Pulse rate, automated reading 2.6 8.5 18.7 3.5 0.5 3.6 0.3 -0.5 4.2 2.1 4.2 4.2 0.2 4.3 0.3
Alcohol intake frequency. 0.0 0.1 0.3 -0.3 0.6 0.6 -0.4 -0.4 0.0 -0.3 0.1 -0.0 -0.1 -0.1 0.5
Comparative height size at age 10 0.0 0.1 1.0 0.2 1.0 -0.2 -0.2 -0.6 0.1 -0.2 -0.0 0.2 0.0 0.1 0.0
Number of full sisters 0.6 0.7 2.9 0.2 -0.6 1.2 -1.2 -1.7 0.5 -0.7 0.2 0.5 -0.9 0.5 -0.0
Suffer from ‘nerves’ 1.7 2.6 5.7 2.1 -0.3 2.4 -0.5 -0.5 2.3 0.7 2.1 2.3 -0.1 2.3 -0.4
Overall health rating 3.0 6.4 16.0 2.1 0.9 4.0 -1.5 -1.6 3.6 0.2 3.1 3.7 -1.2 3.5 -0.2
Chest pain or discomfort 1.8 2.5 5.9 1.4 0.5 2.4 -1.4 -2.0 2.0 -0.3 1.9 2.1 -0.4 1.9 -0.4
Had major operations 3.3 3.9 6.7 1.7 2.5 -0.9 2.6 2.3 1.6 2.6 1.7 1.5 1.3 1.4 2.5
Age at last live birth 0.7 1.0 2.8 -0.7 -1.7 -0.4 0.0 -0.1 -1.2 -0.5 -0.9 -1.0 -1.0 -1.0 -1.6
Family relationship satisfaction 2.3 2.9 8.0 -0.1 -1.6 2.8 -2.2 -1.7 1.1 -1.3 0.9 1.1 -2.7 1.2 -1.5
Leg pain on walking 1.9 2.3 6.3 1.4 0.8 1.4 0.2 -0.4 2.3 1.2 2.1 2.5 0.6 2.2 0.7
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 2.2 1.5 -0.2 0.6 0.8 1.2 1.3 1.2 1.3 1.4 -0.5 1.2 0.2
Commuting to job workplace: Car/motor vehicle 0.2 0.3 1.2 -0.7 -0.7 -0.0 -0.4 -0.2 -0.1 -0.4 -0.1 -0.0 -1.1 -0.1 -0.7
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.7 -0.4 -1.3 -0.7 0.8 0.9 -0.7 0.3 -0.5 -0.7 -0.9 -0.7 -0.5
Medication: Aspirin 0.2 0.3 1.1 0.5 -0.4 -0.7 0.9 0.8 -0.1 0.5 -0.1 0.1 0.2 -0.1 1.0
Supplements: Vitamin C 1.5 1.8 4.4 -1.6 0.1 0.0 -2.1 -1.6 -1.3 -2.0 -1.5 -1.3 -1.0 -1.1 -0.2
Knee pain experienced in last month 1.0 1.5 4.3 1.3 -0.4 2.1 -0.6 -1.2 1.6 0.1 1.3 1.9 -0.6 1.5 0.2
Hypertension (Self-reported) 1.0 2.7 4.9 2.2 1.9 2.2 0.6 0.4 1.9 1.2 1.8 2.0 -0.2 1.9 1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 4.2 0.5 0.1 2.1 -1.1 -0.8 0.7 -0.5 0.6 0.9 -0.2 0.8 -0.5
Illnesses of father: Heart disease 0.3 0.5 2.2 -0.5 -0.4 -1.0 -0.0 0.2 -0.8 -0.3 -0.7 -0.5 -1.5 -0.8 -0.1
Illnesses of siblings: Diabetes 1.6 1.9 5.9 0.6 -1.3 2.4 -1.9 -2.0 1.0 -1.0 0.8 0.8 -1.6 1.1 -0.8
Smoking status: Previous 0.6 1.0 3.0 0.6 0.3 -1.7 1.5 1.0 0.7 1.4 0.7 0.8 -0.1 0.5 1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 2.4 1.5 -1.2 0.7 -0.4 -0.7 1.4 0.4 1.2 1.5 0.7 1.4 -1.4
Whole body fat-free mass 0.6 3.3 9.4 -0.2 -0.6 2.1 -2.9 -2.9 0.7 -2.0 0.2 0.8 -1.5 0.6 -3.1
Leg fat-free mass (right) 0.9 4.9 13.8 -0.5 -0.6 2.8 -3.7 -3.7 0.8 -2.6 0.3 1.0 -1.7 0.8 -3.4
Arm fat percentage (left) 2.6 10.5 27.8 -1.0 -1.3 5.3 -5.3 -4.1 1.3 -3.6 0.8 1.4 -4.4 1.2 -3.6
Average weekly red wine intake 0.2 0.3 1.4 0.7 0.6 -0.0 0.4 1.1 -0.1 0.2 -0.1 0.2 -0.6 -0.1 1.2
Handedness (chirality/laterality): Left-handed 0.5 0.6 3.1 -0.9 -0.6 0.2 -0.6 0.0 -0.7 -0.8 -0.7 -0.7 -1.8 -0.7 -0.1
Mood swings 0.4 0.7 1.6 0.7 1.0 -0.2 0.6 0.2 1.0 0.8 1.1 1.0 1.2 0.9 -0.4
Loneliness, isolation 2.0 2.7 6.6 1.5 -0.2 2.6 -1.2 -0.9 2.4 0.1 2.1 2.3 -0.1 2.4 -0.7
Long-standing illness, disability or infirmity 0.6 0.9 2.2 1.4 0.2 1.1 0.1 -0.1 1.4 0.7 1.2 1.4 -0.4 1.5 0.0
Ever had bowel cancer screening 1.2 1.4 2.6 1.2 0.9 -0.5 1.6 1.6 1.1 1.6 1.2 1.0 1.5 0.8 0.8
Diabetes diagnosed by doctor 1.8 3.0 8.2 0.8 1.5 2.9 -1.7 -1.9 1.8 -0.8 1.5 1.8 -2.2 1.8 1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 1.6 1.2 0.6 0.4 1.1 1.0 1.1 1.3 1.1 1.0 -0.3 1.2 1.1
Friendships satisfaction 1.6 2.0 7.3 -0.8 -2.2 1.5 -1.8 -1.5 0.1 -1.4 -0.2 0.4 -2.7 0.0 -1.3
Qualifications: nursing, teaching 1.9 3.0 6.9 -2.5 -0.3 -0.1 -1.8 -0.6 -2.0 -2.1 -2.0 -1.9 -2.6 -1.8 -0.2
Commuting to job workplace: Walk 0.4 0.5 2.3 0.5 0.8 -0.9 0.7 0.3 0.1 0.5 -0.1 0.4 0.5 0.1 1.5
Eye problems/disorders: Cataract 0.8 0.9 2.0 0.8 0.1 1.4 -0.3 -0.1 1.3 0.3 1.3 1.2 -0.2 1.4 -0.9
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 1.7 0.4 0.1 -0.8 1.1 1.3 -0.2 0.7 -0.1 -0.2 -0.3 -0.3 -0.6
Medication for cholesterol 0.2 0.3 2.0 -0.2 -0.7 -0.4 -0.1 -0.3 -0.3 -0.2 -0.3 -0.2 0.3 -0.3 -1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.5 2.6 1.5 0.5 -0.9 1.6 1.5 1.2 1.6 1.4 0.9 1.1 1.1 0.3
Back pain experienced in last month 0.8 1.2 2.5 1.6 1.2 -0.0 1.3 1.1 1.1 1.4 1.2 1.0 0.6 1.1 0.1
Mineral and other dietary supplements 0.2 0.2 0.7 0.0 -0.8 0.1 0.1 -0.2 0.6 0.3 0.7 0.6 0.5 0.7 -0.5
Breast cancer (self-reported) 1.0 1.2 4.3 -0.8 -1.1 -2.1 1.0 0.9 -1.1 0.3 -1.1 -1.2 1.2 -1.0 0.5
Asthma (self-reported) 1.0 2.1 4.5 1.3 -0.0 1.9 -0.8 -1.0 2.1 0.2 1.8 2.0 -0.9 2.1 -0.9
Osteoporosis (self-reported) 1.5 1.9 7.4 1.3 2.7 -0.9 1.5 0.9 0.5 1.3 0.5 0.7 0.7 0.5 2.4
Osteoarthritis (self-reported) 1.3 1.7 5.0 0.4 -1.3 2.2 -1.3 -1.6 1.3 -0.4 1.0 1.2 -0.7 1.4 -1.5
Medication: Aspirin 0.2 0.2 1.3 0.3 0.0 -0.4 0.6 0.5 -0.4 0.1 -0.4 -0.0 -0.2 -0.4 1.1
Medication: Gliclazide 5.0 5.7 13.0 3.6 1.9 1.8 1.3 0.8 3.1 2.4 3.1 3.1 0.2 3.2 1.2
Illnesses of father: None of the above (group 1) 1.0 1.3 3.6 0.9 0.4 -0.4 1.5 1.3 1.0 1.6 1.1 0.6 1.9 1.1 0.5
Smoking status: Current 2.9 4.6 8.5 2.3 2.6 -0.2 2.0 1.4 2.0 2.3 2.1 1.9 2.8 1.9 2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.3 -0.3 -1.0 1.0 -1.0 -1.2 -0.2 -0.7 -0.4 -0.2 -0.4 -0.1 -0.5
Whole body water mass 0.6 3.3 9.7 -0.1 -0.5 2.2 -2.9 -2.9 0.8 -1.9 0.3 0.9 -1.5 0.8 -3.1
Leg predicted mass (right) 0.9 4.8 13.3 -0.5 -0.6 2.7 -3.6 -3.6 0.8 -2.6 0.3 1.0 -1.7 0.8 -3.3
Arm fat mass (left) 2.4 10.0 27.1 -0.9 -1.4 4.8 -5.2 -4.3 1.2 -3.6 0.6 1.2 -4.1 1.1 -3.9
Number of self-reported non-cancer illnesses 0.5 0.8 2.1 1.4 0.8 1.4 0.2 0.7 1.0 0.5 0.9 1.1 -0.5 1.0 0.5
Average weekly champagne plus white wine intake 0.2 0.2 0.7 0.2 0.3 0.9 -0.8 -0.7 0.1 -0.6 -0.1 0.1 -0.4 0.2 0.3
Miserableness 0.2 0.3 0.6 0.5 0.4 0.0 0.5 0.4 0.6 0.7 0.8 0.7 0.4 0.5 -0.8
Guilty feelings 0.5 0.7 1.4 1.0 0.9 0.5 0.4 0.1 1.2 0.9 1.2 1.1 0.6 1.1 -0.1
Wears glasses or contact lenses 0.7 0.8 2.7 -0.4 -1.0 1.0 -1.4 -1.0 -0.1 -1.2 -0.2 -0.1 -1.6 -0.1 -0.7
Ever taken oral contraceptive pill 1.2 1.3 3.2 -0.3 1.6 1.8 -1.2 -1.7 1.1 -0.5 0.9 1.2 0.2 1.0 0.6
Hearing aid user 0.9 1.1 3.9 -0.4 0.3 -2.0 1.4 1.7 -0.8 0.7 -0.4 -0.9 1.1 -0.8 -0.0
Mother’s age at death 0.8 1.0 2.9 0.3 1.1 -1.4 1.4 1.2 -0.6 0.8 -0.4 -0.5 0.9 -0.6 1.7
Financial situation satisfaction 0.7 0.8 2.7 1.1 -1.6 -0.1 0.3 0.6 1.1 0.6 1.1 1.2 0.1 1.1 -0.4
Tinnitus: Yes, now most or all of the time 0.4 0.4 0.8 0.8 0.0 -0.7 0.8 0.8 0.6 0.9 0.5 0.7 0.5 0.6 -0.0
Commuting to job workplace: Public transport 1.1 1.4 2.7 -0.7 -1.6 0.9 -1.6 -1.5 -0.6 -1.4 -0.7 -0.5 -1.1 -0.7 -1.6
Eye problems/disorders: Glaucoma 0.3 0.4 1.8 -0.1 -0.0 -1.0 1.0 0.3 -0.3 0.7 -0.1 -0.2 1.3 -0.4 -0.4
Medication: Blood pressure 0.3 0.6 2.4 -0.1 0.4 1.6 -1.0 -0.8 0.1 -0.9 -0.1 0.0 -1.4 0.1 0.0
Pain type(s) experienced in last month: Hip pain 1.1 1.3 2.6 1.6 -0.4 -0.4 1.0 0.5 1.5 1.5 1.6 1.4 -0.1 1.6 0.5
Supplements: Fish oil (including cod liver oil) 0.3 0.3 1.1 1.1 0.8 -0.1 0.6 0.9 0.2 0.7 0.1 0.1 0.1 0.2 0.7
High cholesterol (Self-reported) 0.8 1.5 5.4 0.3 0.1 -1.8 1.6 1.8 -0.9 0.9 -0.8 -0.7 0.0 -0.8 2.3
Medication: Bendroflumethiazide 0.3 0.4 2.8 0.6 0.5 0.3 0.3 0.7 0.3 0.3 0.0 0.6 -0.4 0.2 1.7
Medication: Paracetamol 1.1 1.7 4.5 1.0 0.5 1.1 0.1 -0.3 2.1 1.0 2.0 2.1 0.2 2.0 -0.7
Medication: Lisinopril 1.5 1.9 4.4 1.8 1.3 0.3 1.5 0.9 1.3 1.7 1.4 1.4 0.2 1.4 2.1
Medication: Atorvastatin 0.3 0.3 0.9 0.7 0.4 0.3 0.8 0.9 0.3 0.7 0.3 0.5 -0.6 0.2 0.6
Illnesses of father: High blood pressure 0.6 0.7 1.5 -0.9 1.2 0.1 -0.6 -0.5 -0.9 -0.7 -1.0 -0.8 -0.8 -1.0 0.9
Alcohol drinker status: Never 0.2 0.2 0.7 -0.4 -0.4 0.8 -0.5 -0.4 0.2 -0.4 0.1 0.3 -0.7 0.0 0.5
Ever smoked 0.6 1.0 6.1 0.5 1.2 -0.7 0.9 0.5 0.8 1.0 0.7 0.9 -0.2 0.7 2.5
Basal metabolic rate 0.9 5.1 13.3 -0.3 -0.8 2.9 -3.6 -3.5 0.9 -2.5 0.4 1.1 -2.2 0.9 -3.5
Leg fat percentage (left) 2.3 8.3 22.1 -0.6 -2.0 4.7 -4.3 -3.4 1.3 -2.9 0.8 1.4 -4.1 1.1 -3.4
Arm fat-free mass (left) 0.7 3.6 10.1 0.1 -0.9 2.5 -2.9 -2.9 1.1 -1.8 0.5 1.2 -1.7 1.0 -3.2
Number of operations (self-reported) 0.3 0.4 1.8 -0.3 1.1 0.5 -0.4 0.1 0.4 -0.3 0.2 0.4 -1.4 0.3 1.0
Average weekly beer plus cider intake 0.4 0.6 1.2 0.8 -0.6 0.9 -0.2 -1.1 0.9 0.4 0.9 0.8 0.6 1.0 -0.4
Irritability 0.5 0.8 2.5 -0.6 0.1 -1.6 0.5 0.9 -1.2 -0.2 -1.2 -1.0 -0.2 -1.2 0.0
Risk taking 0.3 0.4 1.2 -0.1 1.1 -1.0 0.6 0.7 -0.3 0.4 -0.2 -0.2 0.4 -0.2 1.0
Ever had prostate specific antigen (PSA) test 0.5 0.5 2.0 -0.7 -0.4 -1.4 0.7 0.4 -0.8 0.0 -0.7 -0.6 -0.3 -1.0 0.8
Fractured/broken bones in last 5 years 1.7 2.2 4.8 2.0 1.5 0.4 1.8 0.4 1.3 1.9 1.3 1.3 2.2 1.2 1.3
Age started oral contraceptive pill 0.2 0.2 1.6 -0.1 0.3 -0.4 0.6 0.4 -0.3 0.3 -0.3 -0.3 1.2 -0.3 0.3
Diastolic blood pressure, automated reading 0.4 1.2 6.2 1.0 -0.0 2.5 -0.4 -0.4 1.3 0.3 1.2 1.1 -0.0 1.4 0.1
Ever depressed for a whole week 0.3 0.4 0.8 0.4 -0.5 -0.0 0.2 0.7 0.9 0.5 0.9 0.9 -0.7 0.8 -0.3
Unable to work because of sickness or disability 0.9 1.2 2.2 1.4 1.5 0.2 1.1 0.5 1.1 1.3 1.2 1.0 1.1 1.1 0.7
Commuting to job workplace: Cycle 0.2 0.2 0.5 0.7 -0.1 0.2 0.4 -0.7 0.5 0.5 0.4 0.6 -0.1 0.5 -0.1
Myopia 1.0 1.5 3.0 -1.4 -1.0 -0.5 -0.4 -0.3 -1.7 -1.1 -1.6 -1.7 -1.2 -1.7 -0.5
Vascular/heart problems diagnosed by doctor 0.3 0.9 3.3 -1.3 -0.7 -1.8 0.1 0.1 -0.9 -0.2 -0.8 -1.1 0.7 -0.9 -0.8
Cholesterol lowering medication 0.3 0.4 1.8 -0.1 -0.1 -0.8 0.5 -0.0 -0.7 0.1 -0.7 -0.5 0.5 -0.7 1.3
Medication: Omeprazole (e.g. Zanprol) 2.0 2.4 5.8 2.4 0.8 0.9 0.9 0.7 1.9 1.6 1.9 2.0 1.3 1.8 1.0
Pain experienced in last month 4.2 7.1 14.5 -3.5 -1.1 -2.5 -1.0 -0.5 -3.8 -2.4 -3.8 -3.8 -1.0 -3.7 -0.5
Supplements: Calcium 0.7 0.8 4.0 -0.1 2.0 -0.3 0.7 0.7 -0.4 0.2 -0.5 -0.0 0.1 -0.5 1.9
Basal cell carcinoma (self-reported) 1.9 2.2 9.4 1.2 1.0 -1.5 2.1 1.8 0.5 1.7 0.6 0.9 0.8 0.5 3.1
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.6 -0.1 0.5 -0.6 0.7 0.8 -0.5 0.3 -0.5 -0.4 -0.9 -0.4 1.3
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.9 0.8 1.4 -0.8 0.9 1.2 -0.2 0.6 0.0 -0.4 1.0 -0.1 0.5
Heart disease (siblings) 0.5 0.7 2.5 0.5 -0.1 1.5 -0.9 -0.8 0.6 -0.3 0.4 0.8 -1.6 0.6 -0.1
Alcohol drinker status: Previous 1.1 1.3 2.9 1.4 0.4 0.8 0.5 0.6 1.6 1.0 1.7 1.5 0.3 1.6 0.1
Pack years of smoking 0.1 0.1 0.5 0.2 -0.7 0.0 0.1 0.6 0.1 0.1 -0.1 0.1 -0.1 0.1 -0.4
Impedance of whole body 0.2 0.9 3.0 0.5 -0.0 -0.8 1.6 1.6 0.1 1.3 0.2 0.3 0.5 0.1 1.7
Leg fat mass (left) 2.4 9.3 22.5 -0.6 -1.9 4.7 -4.7 -4.0 1.4 -3.2 0.8 1.5 -4.0 1.3 -3.8
Arm predicted mass (left) 0.7 3.5 8.8 0.1 -0.9 2.5 -2.8 -2.8 1.0 -1.8 0.5 1.1 -1.9 0.9 -3.0