Hub : Genes

MAPK6

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Testis 0.1990 0.096 0.00027 0.003 NA 0.002 NA 0.046 0.220 NA 0.27 NA 0.0042
2 GTEx Thyroid 0.0440 0.026 0.00560 0.017 NA -0.002 NA 0.007 0.016 NA 0.54 NA 0.0880
3 YFS Blood 0.0148 0.008 0.00980 0.000 0.004 0.001 0.005 0.000 0.430 0.0099 0.11 0.0086 0.2600

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.3 2.1 3.5 -1.9 -0.6 1.5
Bipolar Disorder or Schizophrenia 0.7 1.8 4.2 -2.1 -0.1 1.0
Depressed Affect (Nagel 2018) 1.4 3.0 5.6 2.4 1.1 -1.5
Depression (Nagel 2018) 2.1 3.2 5.0 2.2 1.7 -1.3
Intelligence (Savage-Jansen 2018) 0.8 2.4 6.9 0.4 2.6 -0.3
Neuroticism (Nagel 2018) 0.8 1.9 2.4 1.5 1.1 -1.5
Schizophrenia (2018) 0.2 0.4 1.2 -1.1 0.3 0.0
Schizophrenia vs Biploar Disorder 0.1 0.2 0.3 0.5 -0.1 -0.6
Worry (Nagel 2018) 0.7 1.5 2.5 0.8 1.2 -1.6
Alzheimer’s Disease (in mother) 0.1 0.1 0.3 -0.6 -0.2 0.1
Alzheimer’s Disease (in father) 2.2 2.4 5.0 2.2 1.3 -0.8
Alzheimer’s Disease (including proxy) 0.8 1.2 1.8 1.3 0.9 -1.0
Crohns Disease (2017) 0.1 0.3 0.4 -0.3 0.6 -0.5
Irritable Bowel Disease (IBD) 0.2 0.5 1.0 -0.6 1.0 -0.3
Ulcerative Colitis (UC) 0.2 0.5 1.0 -0.6 1.0 -0.1
Major Depression (MDD) 2.6 3.1 4.8 2.2 1.7 -1.3
Reaction Time 1.5 2.8 6.8 0.7 1.0 -2.6
Verbal and Numeric Reasoning (VNR) 0.8 1.9 4.2 0.9 2.1 -0.7
Breast Cancer 0.2 0.5 1.1 -1.1 0.2 0.5
Ovarian Cancer 0.1 0.1 0.3 0.2 0.3 -0.5
Prostate Cancer 1.6 2.3 3.6 1.8 1.9 0.2
Age at First Birth 1.5 2.1 5.0 -1.2 -0.0 2.2
Bipolar Disorder (2011) 0.4 0.4 1.1 -0.0 -0.3 1.1
Body Mass Index (BMI) (2010) 4.1 5.6 7.1 2.7 2.6 -1.8
Coronary Artery Disease (CAD) 0.3 0.4 0.6 0.7 0.4 -0.8
Crohns Disease (2012) 0.2 0.4 0.9 0.1 1.0 -0.5
Mean Putamen Volume 2.6 3.0 6.5 1.4 2.5 -0.8
Fasting Glucose 0.6 0.8 2.1 0.4 0.2 -1.5
HbA1C 1.8 2.0 4.7 -2.2 -1.0 -0.7
HDL Cholesterol 2.3 3.8 7.9 1.7 2.8 -0.8
LDL Cholesterol 0.4 0.6 1.3 -0.6 0.4 -1.1
Lupus 0.5 0.8 1.6 0.7 0.6 1.3
Neuroticism (2016) 0.8 1.1 2.8 0.7 0.3 -1.7
Primary Biliary Cirrhosis 0.4 0.5 0.8 0.8 0.1 -0.9
Rheumatoid Arthritis 0.2 0.3 0.6 0.6 0.7 -0.2
Schizophrenia (2014) 0.2 0.5 1.4 -1.2 0.2 0.3
Triglycerides 1.1 1.9 3.5 -0.7 -1.3 -1.9
Type 2 Diabetes (T2D) (2012) 0.3 0.4 0.5 0.7 -0.6 -0.6
Ulcerative Colitis 0.5 0.8 2.3 -1.5 -0.2 0.2
Blood Eosinophil Count 0.3 2.1 5.4 0.8 2.3 -0.3
Blood Platelet Count 0.3 3.3 6.4 1.8 2.5 -0.6
Blood Red Count 0.0 0.3 0.7 0.3 0.2 -0.8
Blood White Count 0.2 1.1 2.4 0.3 0.9 -1.6
Heel T-Score 0.4 3.5 10.4 0.2 3.2 0.3
BMI 3.8 22.0 40.5 3.8 6.4 -3.3
Height 0.2 3.0 3.6 -1.7 -1.9 1.6
Waist Hip Ratio (WHR) 0.6 2.9 5.0 1.9 -0.4 -2.2
Systolic Blood Pressure 0.9 4.6 5.9 -2.0 -1.9 -2.4
Smoking Status 2.0 4.8 9.8 -2.1 -3.1 -0.3
Allergy or Eczema 0.2 0.4 0.9 0.9 0.6 0.2
Cardiovascular Disease 0.6 1.9 5.2 -0.2 -0.6 -2.3
Hypothyroidism (self reported) 0.7 1.6 2.9 -1.4 0.1 1.7
Respiratory disease 1.3 2.8 4.2 2.0 1.5 -1.4
Type 2 Diabetes (T2D) (2018) 3.7 6.9 7.6 2.5 2.6 -2.8
Lung FEV1/FVC ratio 0.4 1.8 2.2 -1.4 -1.1 -1.5
Lung FVC 0.6 2.9 6.9 -1.3 -2.6 -0.4
Neuroticism 0.3 0.8 1.8 0.6 0.5 -1.3
Chronotype (morning person) 1.2 2.7 3.7 -1.9 -1.3 -1.7
Hair Pigment 0.0 0.9 1.4 1.0 -0.4 -1.2
Tanning 0.2 2.2 3.6 -1.8 -1.9 -0.2
Hand grip strength (left) 1.9 5.0 5.6 -2.4 -2.1 2.2
Number of treatments/medications taken 0.4 0.6 1.5 1.2 0.6 -0.2
Average weekly spirits intake 2.9 3.6 7.2 -1.8 -0.7 2.7
Sensitivity / hurt feelings 0.3 0.6 0.9 -0.7 -1.0 0.5
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.3 0.8 1.1 -0.0
Hearing difficulty/problems: Yes 5.6 8.6 13.4 3.5 3.7 -0.6
Relative age of first facial hair 0.8 1.6 3.1 -0.8 -1.8 1.0
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 0.9 0.6 0.9 -0.8
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.8 1.3 -0.0 -0.4
Ever had hysterectomy (womb removed) 3.3 3.8 4.9 2.2 2.0 -1.6
Systolic blood pressure, automated reading 0.6 1.7 2.7 -1.0 -1.1 -1.6
Eye problems/disorders: Diabetes related eye disease 2.1 2.3 4.5 0.9 1.3 -2.1
Angina 0.9 1.2 2.8 0.8 1.7 -0.5
Medication for hormone replacement therapy 0.3 0.3 0.7 -0.3 -0.9 -0.2
Vitamin and mineral supplements 0.3 0.3 0.9 -0.3 -1.0 0.1
Supplements: Zinc 0.9 1.0 2.9 0.2 0.3 -1.7
Medication: Co-codamol 2.7 3.2 5.6 2.4 1.8 0.8
Medication: Metformin 4.8 6.8 8.5 2.9 2.5 -2.4
Diabetes (father) 0.6 0.8 1.5 -1.2 -0.6 -0.6
Diabetes (mother) 4.2 5.4 8.1 2.8 1.3 -2.5
Severe depression (siblings) 0.5 0.5 1.3 0.3 0.4 -1.1
Pack years adult smoking proportion 0.5 0.8 1.2 -0.9 -0.7 1.1
Impedance of leg (right) 1.7 8.4 12.8 -3.5 -3.6 0.7
Leg fat-free mass (left) 1.1 5.8 11.2 2.3 3.4 -1.0
Trunk fat percentage 1.5 6.0 11.3 0.9 3.4 -2.4
Hand grip strength (right) 0.9 2.4 4.0 -1.4 -1.0 2.0
Townsend deprivation index at recruitment 0.9 1.2 1.9 1.2 0.6 -1.4
Current tobacco smoking 0.1 0.1 0.3 -0.2 -0.3 0.5
Average weekly fortified wine intake 1.2 1.4 2.6 -1.6 -0.2 1.3
Maternal smoking around birth 1.8 2.6 6.6 1.1 -0.4 -2.6
Fed-up feelings 1.7 3.1 6.5 1.7 0.3 -2.5
Frequency of unenthusiasm / disinterest in last 2 weeks 2.5 3.4 4.9 1.6 2.2 -1.6
Relative age voice broke 0.9 1.4 2.8 -0.8 -0.8 1.7
Taking other prescription medications 1.8 2.8 5.0 1.5 2.2 -1.0
Age when periods started (menarche) 0.1 0.3 0.6 0.8 -0.1 -0.6
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.2 0.5 0.1 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.6 2.7 0.7 1.6 -1.3
Tinnitus: Yes, but not now, but have in the past 3.1 3.3 6.7 2.6 1.2 -1.4
Qualifications: CSEs or equivalent 1.2 1.6 3.1 1.2 0.5 -1.8
Serious illness, injury or assault to yourself 1.0 1.2 3.0 -0.3 -0.6 1.7
High blood pressure 0.4 1.2 3.6 -0.1 -0.2 -1.9
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.4 0.6 0.7 0.0
Multivitamins +/- minerals 0.0 0.0 0.1 0.0 0.2 0.2
Stomach or abdominal pain in last month 3.8 4.7 6.5 1.9 2.0 -2.5
Supplements: Glucosamine 0.4 0.5 0.7 0.5 0.8 0.8
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.6 0.4 1.3 0.6
Medication: Atenolol 0.3 0.4 0.6 -0.7 -0.3 0.8
Medication: Levothyroxine sodium 2.4 4.1 6.2 -2.2 -1.1 2.5
Sitting height 1.7 11.8 19.2 -3.1 -4.4 2.6
Chronic bronchitis/emphysema (father) 1.4 1.6 3.8 1.1 -0.2 1.9
High blood pressure (mother) 1.1 1.5 4.1 0.8 2.0 -0.0
Body mass index (BMI) 3.4 14.5 25.1 3.1 5.0 -3.0
Impedance of leg (left) 2.4 11.9 17.8 -4.2 -4.2 0.8
Leg predicted mass (left) 1.1 6.1 11.5 2.4 3.4 -1.0
Trunk fat mass 1.4 6.0 12.0 1.2 3.5 -2.1
Waist circumference 3.7 13.6 19.8 2.9 4.4 -3.6
Number of incorrect matches in round 0.1 0.2 0.5 -0.2 -0.3 0.7
Past tobacco smoking 3.4 6.3 15.3 1.7 3.9 0.7
Alcohol usually taken with meals 0.5 0.8 2.1 -0.5 0.3 1.4
Nervous feelings 0.6 1.2 3.3 0.1 0.4 -1.8
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 2.2 1.3 1.5 -0.5
Hearing difficulty/problems with background noise 4.0 6.4 9.8 3.1 3.1 -0.2
Hair/balding pattern: Pattern 2 1.1 1.4 3.3 0.4 0.8 -1.8
Had menopause 0.9 1.1 1.4 1.2 1.2 -0.7
Had other major operations 0.3 0.3 0.8 0.2 0.9 -0.3
Forced vital capacity (FVC) 0.5 2.0 5.1 -1.0 -2.2 -0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.8 3.8 0.5 1.9 -1.1
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 2.8 0.5 -0.2 -1.7
Qualifications: None of the above 0.3 0.7 1.3 -0.0 -1.1 -0.9
Financial difficulties in last 2 years 0.9 1.2 2.2 1.1 1.5 -0.5
Mouth/teeth dental problems 0.3 0.4 1.1 -1.1 -0.3 0.2
Heart attack 0.4 0.5 0.5 -0.7 -0.7 0.7
Allergy 0.2 0.4 0.4 -0.6 -0.7 0.6
Pain all over the body in last month 0.7 0.7 1.1 1.1 -0.2 -1.0
Diabetes (self-reported) 2.5 3.8 4.8 1.7 1.9 -2.2
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 3.3 0.4 0.6 1.8
Medication: Ramipril 0.3 0.4 0.8 -0.9 0.5 0.5
Medication: Simvastatin 2.4 3.5 4.8 -1.9 -1.4 2.2
Fluid intelligence score 0.1 0.3 0.8 -0.3 0.9 -0.1
Illnesses of siblings 0.1 0.2 0.3 -0.4 -0.6 0.3
Neuroticism score 1.0 2.2 2.8 1.5 1.2 -1.7
Weight 1.7 8.2 15.9 2.2 4.0 -1.9
Impedance of arm (right) 0.2 0.8 1.6 -1.3 -0.7 0.5
Arm fat percentage (right) 4.7 18.5 33.1 3.4 5.8 -3.3
Trunk fat-free mass 0.4 2.0 3.6 1.6 1.9 -0.2
Hip circumference 1.8 7.8 16.7 1.8 4.1 -1.9
Time employed in main current job 1.2 1.3 3.3 -0.8 -1.8 0.4
Alcohol intake versus 10 years previously 0.2 0.3 0.6 -0.3 -0.0 -0.8
Father’s age at death 0.9 1.2 2.3 1.2 1.5 0.2
Worrier / anxious feelings 0.6 1.2 2.9 0.7 1.7 -0.4
Frequency of tiredness / lethargy in last 2 weeks 8.9 14.5 23.3 3.9 4.8 -2.2
Falls in the last year 0.4 0.5 1.4 1.2 0.2 -0.4
Hair/balding pattern: Pattern 3 0.1 0.2 0.4 0.3 -0.0 -0.6
Number of live births 0.5 0.7 1.4 0.9 0.1 1.2
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 2.9 -0.9 -1.7 -0.4
Pulse rate 1.9 3.1 4.1 1.5 1.8 -2.0
Happiness 1.8 2.2 5.9 0.3 0.7 -2.4
Noisy workplace 7.5 9.3 13.6 3.7 3.6 -1.1
Qualifications: A levels/AS levels or equivalent 2.7 6.1 13.3 -2.0 -1.0 3.7
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.9 1.7 0.8 -0.5 -1.3
Mouth/teeth dental problems: Dentures 0.3 0.6 1.0 1.0 -0.2 -0.9
Asthma 1.2 2.3 3.0 1.7 1.1 -1.7
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.2 1.9 -0.7 -1.4 1.2
Medication: Cholesterol lowering 2.6 4.1 4.8 -1.9 -2.0 2.2
Depression (self-reported) 2.2 2.6 3.3 1.6 1.8 -1.5
Medication: Lansoprazole 1.3 1.5 1.7 1.1 1.3 -1.3
Prospective memory result 0.2 0.2 0.3 -0.5 -0.2 0.6
Lung cancer (father) 0.8 0.9 1.8 0.9 -0.3 -1.4
Illnesses of mother 0.4 0.5 1.0 -0.1 -1.0 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.1 2.4 -0.9 -1.5 -0.5
Pulse wave Arterial Stiffness index 1.8 2.2 2.4 -1.5 -1.6 1.4
Impedance of arm (left) 0.5 2.4 3.8 -1.9 -1.7 0.7
Arm fat mass (right) 3.3 13.7 25.9 2.9 5.1 -2.6
Trunk predicted mass 0.3 1.8 3.1 1.5 1.8 -0.1
Standing height 0.4 3.7 4.8 -1.7 -1.8 2.2
Length of working week for main job 1.4 1.6 2.4 -0.4 -1.5 1.5
Exposure to tobacco smoke at home 0.5 0.6 1.5 0.3 1.2 0.4
Breastfed as a baby 0.3 0.4 1.0 0.4 1.0 -0.3
Tense / ‘highly strung’ 0.4 0.6 1.6 -0.4 1.3 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 4.1 6.2 10.4 2.1 1.9 -3.2
Hair/balding pattern: Pattern 4 2.5 6.0 7.8 2.7 2.8 -1.8
Birth weight of first child 1.1 1.9 2.5 1.2 1.6 -1.4
Peak expiratory flow (PEF) 0.8 1.9 3.2 -1.8 -1.6 -0.2
Pulse wave reflection index 0.9 1.1 1.6 -1.3 -1.0 1.0
Ever highly irritable/argumentative for 2 days 0.1 0.2 0.3 -0.0 0.5 -0.5
Loud music exposure frequency 3.3 3.6 6.0 2.2 2.5 0.0
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 1.5 0.6 1.0 1.2
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.3 0.3 0.5 0.6
Blood clot in the leg (DVT) 0.3 0.4 1.0 -0.1 -0.6 1.0
Medication: Paracetamol 0.9 1.5 4.3 0.0 -0.4 -2.1
Headache pain in last month 0.9 1.5 3.1 1.8 1.1 -0.7
Medication for cholesterol, blood pressure or diabetes 1.1 1.8 2.4 1.5 1.1 -1.4
Glaucoma (self-reported) 0.1 0.1 0.2 0.1 -0.5 -0.1
Gout (self-reported) 0.2 0.2 0.7 0.2 -0.1 0.8
Hypothyroidism/myxoedema (self-reported) 1.0 2.0 3.9 -1.5 0.2 2.0
Medication: Amlodipine 0.9 1.3 2.7 1.1 1.6 0.3
Medication: Ventolin 100micrograms inhaler 1.0 1.3 2.2 1.2 1.5 -0.4
Birth weight 1.2 2.6 4.0 2.0 2.0 0.2
Chronic bronchitis/emphysema (mother) 0.0 0.0 0.1 -0.1 -0.1 -0.3
High blood pressure (siblings) 0.3 0.4 0.7 -0.3 -0.5 0.9
Forced vital capacity (FVC), Best measure 0.4 1.6 3.9 -0.8 -2.0 -0.3
Body fat percentage 2.1 8.3 15.0 1.5 3.9 -2.8
Leg fat percentage (right) 2.2 8.1 12.8 1.8 3.6 -2.9
Arm fat-free mass (right) 0.1 0.7 1.2 0.9 1.1 -0.3
Exposure to tobacco smoke outside home 0.3 0.4 0.6 0.8 0.7 0.1
Comparative body size at age 10 0.9 2.4 4.7 -0.1 2.2 1.5
Number of full brothers 0.9 1.2 3.2 -0.6 0.2 -1.8
Worry too long after embarrassment 0.1 0.2 0.4 0.7 0.4 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 1.1 0.9 0.2 -1.0
Wheeze or whistling in the chest in last year 3.9 7.0 10.3 3.2 2.7 -1.9
Number of children fathered 0.5 0.5 1.4 1.2 -0.1 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 2.0 2.3 3.1 -1.2 -1.8 -1.6
Age at first live birth 2.1 3.7 8.5 -1.4 -0.7 2.9
Pulse wave peak to peak time 1.6 1.9 2.1 1.3 1.5 -1.4
Health satisfaction 0.6 0.8 1.9 -0.3 0.6 -1.4
Shortness of breath walking on level ground 2.0 2.3 4.6 1.4 2.1 0.7
Qualifications: College or University degree 0.7 2.3 3.8 0.0 1.7 1.9
Eye problems/disorders: None of the above 2.6 3.0 4.5 -2.1 -2.1 0.4
Mouth/teeth dental problems: Loose teeth 0.8 1.0 1.9 1.4 1.0 -0.3
Emphysema/chronic bronchitis 0.5 0.6 0.8 0.6 0.9 -0.7
Medication for pain relief, constipation, heartburn 0.8 1.3 2.2 -1.5 -0.6 1.2
Neck or shoulder pain in last month 6.4 9.0 18.1 4.3 2.6 -1.5
Medication: Blood pressure 0.2 0.3 1.0 0.0 -0.1 1.0
Angina (self-reported) 0.9 1.2 2.8 0.8 1.7 -0.6
Migraine (self-reported) 0.5 0.7 1.4 -0.5 -1.2 0.6
Medication: Ibuprofen 0.3 0.3 0.8 0.2 -0.9 0.4
Medication: Allopurinol 0.5 0.7 1.1 -0.6 -0.8 1.0
Medication: Omeprazole 1.3 1.6 1.8 1.3 1.3 -1.1
Medication: Seretide 50 evohaler 0.1 0.1 0.3 0.1 -0.0 -0.5
Mean time to correctly identify matches 1.5 2.9 4.1 1.2 1.8 -2.0
Heart disease (mother) 0.1 0.1 0.3 -0.1 -0.1 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 2.5 -0.6 -0.6 1.6
Whole body fat mass 1.9 8.0 15.2 1.8 3.9 -2.4
Leg fat mass (right) 2.2 8.7 14.6 2.0 3.8 -2.7
Arm predicted mass (right) 0.2 0.8 1.4 0.8 1.2 -0.6
Pulse rate, automated reading 3.6 11.7 16.8 4.1 2.8 -3.2
Alcohol intake frequency. 1.4 3.3 6.7 1.7 2.6 -0.6
Comparative height size at age 10 0.2 1.3 1.9 0.6 1.3 1.4
Number of full sisters 1.0 1.2 2.7 -0.7 -1.7 -0.5
Suffer from ‘nerves’ 3.0 4.7 5.4 2.0 2.2 -2.3
Overall health rating 5.0 10.8 12.1 3.5 3.3 -3.1
Chest pain or discomfort 10.9 15.7 25.9 5.1 4.3 -1.5
Had major operations 0.7 0.8 1.0 1.0 0.8 0.9
Age at last live birth 1.4 2.0 2.7 1.1 1.6 1.4
Family relationship satisfaction 3.9 4.8 6.9 1.7 2.6 -2.1
Leg pain on walking 2.4 3.0 4.9 1.9 2.2 -0.7
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 0.9 0.2 -0.9 -0.7
Commuting to job workplace: Car/motor vehicle 0.7 0.9 1.8 1.3 0.6 0.6
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 0.8 -0.7 -0.9 -0.0
Medication: Aspirin 0.5 0.7 1.9 -0.3 0.2 1.4
Supplements: Vitamin C 0.3 0.3 0.6 -0.4 0.8 -0.3
Knee pain experienced in last month 2.9 4.5 8.9 2.0 3.0 -0.8
Hypertension (Self-reported) 0.6 1.6 4.5 0.1 -0.4 -2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.7 3.2 6.2 1.3 2.5 -1.3
Illnesses of father: Heart disease 0.4 0.5 1.2 -0.4 -0.3 1.1
Illnesses of siblings: Diabetes 1.4 1.8 2.3 1.2 1.2 -1.5
Smoking status: Previous 3.6 5.4 11.7 -1.2 -3.4 -1.7
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 0.5 -0.6 -0.6 -0.7
Whole body fat-free mass 0.5 3.0 5.6 1.8 2.4 -0.4
Leg fat-free mass (right) 0.9 5.0 9.6 2.1 3.1 -1.0
Arm fat percentage (left) 3.8 15.1 26.3 3.0 5.1 -3.2
Average weekly red wine intake 0.5 0.8 1.5 -0.7 -1.2 0.6
Handedness (chirality/laterality): Left-handed 1.8 2.2 3.0 1.1 1.5 -1.7
Mood swings 1.4 2.6 4.1 2.0 1.7 -0.8
Loneliness, isolation 0.7 1.0 1.6 0.5 1.2 -1.0
Long-standing illness, disability or infirmity 1.4 2.1 3.0 1.5 1.7 -1.0
Ever had bowel cancer screening 0.2 0.2 0.6 0.8 -0.1 0.2
Diabetes diagnosed by doctor 3.3 5.5 7.2 1.9 2.7 -2.4
Ever had stillbirth, spontaneous miscarriage or termination 2.8 3.0 6.9 -1.3 -2.6 -0.6
Friendships satisfaction 0.7 0.8 1.3 0.2 1.1 -1.1
Qualifications: nursing, teaching 1.6 2.6 3.5 0.9 1.9 1.8
Commuting to job workplace: Walk 1.2 1.3 2.8 -1.7 -0.7 -0.9
Eye problems/disorders: Cataract 1.7 1.9 3.7 1.4 1.9 0.1
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 2.5 -0.8 -1.6 0.3
Medication for cholesterol 0.1 0.2 0.3 -0.4 0.2 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.8 1.0 1.0 1.0 -0.5
Back pain experienced in last month 1.5 2.2 3.4 1.8 1.6 -0.7
Mineral and other dietary supplements 0.1 0.2 0.4 -0.3 -0.6 0.2
Breast cancer (self-reported) 0.4 0.5 1.1 -0.5 -0.5 1.0
Asthma (self-reported) 1.2 2.3 3.2 1.7 0.9 -1.8
Osteoporosis (self-reported) 0.5 0.6 1.2 -1.1 -0.7 0.6
Osteoarthritis (self-reported) 1.4 1.8 3.1 0.9 1.7 -1.2
Medication: Aspirin 0.7 0.9 2.7 -0.2 0.3 1.6
Medication: Gliclazide 4.0 4.5 7.1 2.2 1.2 -2.7
Illnesses of father: None of the above (group 1) 5.0 6.2 11.8 -2.6 -3.4 -0.4
Smoking status: Current 0.0 0.1 0.1 -0.2 -0.3 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 1.8 -0.7 -1.3 -0.6
Whole body water mass 0.6 3.2 5.9 1.8 2.4 -0.5
Leg predicted mass (right) 0.9 5.0 9.5 2.1 3.1 -1.0
Arm fat mass (left) 3.1 12.7 22.9 2.6 4.8 -2.9
Number of self-reported non-cancer illnesses 0.8 1.5 2.5 1.4 1.6 -0.2
Average weekly champagne plus white wine intake 1.0 1.4 3.4 0.4 0.9 1.8
Miserableness 1.2 2.1 5.3 2.3 0.9 -0.1
Guilty feelings 3.3 4.9 6.7 2.3 1.7 -2.6
Wears glasses or contact lenses 0.3 0.4 0.8 -0.5 -0.9 0.4
Ever taken oral contraceptive pill 0.5 0.5 1.4 0.1 -0.3 -1.2
Hearing aid user 1.6 1.8 5.0 0.5 -0.0 2.2
Mother’s age at death 0.3 0.3 0.6 0.6 0.2 0.8
Financial situation satisfaction 0.1 0.2 0.4 -0.7 -0.2 -0.2
Tinnitus: Yes, now most or all of the time 0.9 1.1 2.0 -1.4 -1.1 -0.2
Commuting to job workplace: Public transport 0.3 0.4 1.0 -1.0 0.0 -0.2
Eye problems/disorders: Glaucoma 0.3 0.3 0.6 0.5 -0.4 0.8
Medication: Blood pressure 0.8 1.6 4.5 0.1 0.5 -2.1
Pain type(s) experienced in last month: Hip pain 1.1 1.4 2.3 1.0 0.9 -1.5
Supplements: Fish oil (including cod liver oil) 0.3 0.3 0.8 0.2 -0.5 -0.9
High cholesterol (Self-reported) 2.4 4.3 4.8 -2.2 -2.2 1.8
Medication: Bendroflumethiazide 0.1 0.2 0.3 -0.6 -0.0 -0.4
Medication: Paracetamol 1.1 1.7 5.0 0.5 -0.1 -2.2
Medication: Lisinopril 0.6 0.8 1.2 -0.1 -1.1 -1.1
Medication: Atorvastatin 0.1 0.2 0.5 0.0 -0.0 -0.7
Illnesses of father: High blood pressure 2.5 3.1 6.7 1.5 2.6 -0.4
Alcohol drinker status: Never 0.0 0.1 0.1 0.3 0.1 -0.3
Ever smoked 3.0 5.2 11.5 -2.0 -3.4 -0.0
Basal metabolic rate 0.9 4.8 9.2 2.0 3.0 -1.0
Leg fat percentage (left) 2.0 7.2 11.0 1.6 3.3 -2.8
Arm fat-free mass (left) 0.7 3.4 6.0 1.8 2.4 -1.0
Number of operations (self-reported) 1.8 2.7 4.7 1.6 2.2 0.9
Average weekly beer plus cider intake 2.3 3.4 5.6 -1.6 -2.4 -1.4
Irritability 0.0 0.1 0.1 -0.1 -0.3 0.3
Risk taking 0.5 0.7 1.9 0.3 -0.1 1.4
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.4 0.6 0.1 0.5
Fractured/broken bones in last 5 years 0.7 0.9 2.4 1.6 0.4 -0.2
Age started oral contraceptive pill 1.6 2.0 4.9 1.0 2.2 0.3
Diastolic blood pressure, automated reading 0.6 1.9 2.2 -1.2 -1.4 -1.5
Ever depressed for a whole week 0.8 1.0 2.0 0.2 -1.0 -1.4
Unable to work because of sickness or disability 0.9 1.2 2.9 1.7 0.7 -0.5
Commuting to job workplace: Cycle 0.5 0.6 0.7 -0.6 -0.8 -0.9
Myopia 0.5 0.7 1.3 -0.7 -0.6 1.2
Vascular/heart problems diagnosed by doctor 0.3 0.9 2.8 0.1 -0.1 1.7
Cholesterol lowering medication 0.3 0.4 0.8 0.2 0.9 -0.7
Medication: Omeprazole (e.g. Zanprol) 2.1 2.6 3.8 1.6 1.9 -1.2
Pain experienced in last month 5.6 9.3 12.5 -3.5 -2.8 2.8
Supplements: Calcium 1.6 1.8 2.1 1.4 1.4 1.2
Basal cell carcinoma (self-reported) 1.0 1.2 2.0 -1.0 -1.4 0.8
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.6 -0.6 -0.4 0.8
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 1.8 -0.1 -0.7 1.3
Heart disease (siblings) 0.4 0.5 0.9 -0.2 -0.7 -1.0
Alcohol drinker status: Previous 1.3 1.4 3.2 1.8 0.8 0.7
Pack years of smoking 0.4 0.6 1.2 -0.6 -0.6 1.1
Impedance of whole body 1.5 7.9 11.8 -3.4 -3.3 0.8
Leg fat mass (left) 2.0 8.0 13.5 1.9 3.7 -2.6
Arm predicted mass (left) 0.7 3.6 6.2 1.8 2.5 -1.1