Hub : Genes

TMOD2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0590	0.0280	2.3e-03	0.011	0.016	0.002	0.019	0.011	1.4e-02	4.6e-03	1.5e-01	1.7e-03	1.6e-02
2	GTEx	Brain Putamen basal ganglia	0.2700	0.1020	8.2e-04	0.126	NA	0.058	NA	0.117	6.9e-04	NA	1.8e-02	NA	1.1e-03
3	GTEx	Cells Transformed fibroblasts	0.0890	0.0300	7.7e-07	0.104	NA	0.105	NA	0.105	3.3e-08	NA	3.0e-08	NA	3.1e-08
4	GTEx	Esophagus Muscularis	0.0650	0.0340	7.0e-03	0.030	NA	0.000	NA	0.001	6.2e-03	NA	3.1e-01	NA	2.8e-01
5	GTEx	Pancreas	0.2330	0.0870	7.4e-04	0.019	NA	0.035	NA	0.008	5.3e-02	NA	1.3e-02	NA	1.4e-01
6	GTEx	Thyroid	0.0430	0.0230	8.2e-03	0.027	NA	0.025	NA	0.026	3.3e-03	NA	4.7e-03	NA	4.1e-03
7	METSIM	Adipose	0.0298	0.0130	2.3e-04	0.026	0.015	0.014	0.015	0.015	6.7e-05	2.4e-03	2.8e-03	2.3e-03	1.9e-03
8	NTR	Blood	0.0688	0.0170	0.0e+00	0.094	0.084	0.092	0.085	0.091	9.8e-29	9.7e-26	3.0e-28	5.3e-26	9.0e-28
9	YFS	Blood	0.1050	0.0218	0.0e+00	0.187	0.182	0.188	0.190	0.188	6.3e-59	2.8e-57	2.6e-59	4.4e-60	4.2e-59
10	TCGA	Head and Neck Squamous Cell Carcinoma	0.0409	0.0259	1.7e-04	-0.001	0.023	0.014	NA	0.011	5.3e-01	1.2e-03	9.6e-03	NA	1.6e-02
11	TCGA	Kidney Renal Clear Cell Carcinoma	0.0404	0.0224	8.7e-06	0.035	0.036	0.033	NA	0.031	8.1e-05	5.4e-05	1.1e-04	NA	1.6e-04
12	TCGA	Lung Adenocarcinoma	0.0234	0.0177	2.5e-03	0.014	0.019	0.011	NA	0.010	7.3e-03	2.3e-03	1.7e-02	NA	1.9e-02
13	TCGA	Pancreatic Adenocarcinoma	0.1250	0.0780	2.4e-03	0.097	0.052	0.065	NA	0.065	7.0e-05	3.2e-03	1.1e-03	NA	1.0e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.7	1.0	3.1	-1.8	-1.6	0.9	1.4	0.8	-0.5	1.0	0.2	0.3	1.3	0.7	0.4	-1.0
Bipolar Disorder or Schizophrenia	0.6	1.3	4.7	-1.4	-2.0	0.5	2.2	0.8	-0.4	1.2	0.1	0.3	1.4	0.4	0.0	-1.5
Depressed Affect (Nagel 2018)	0.9	1.9	6.9	1.0	1.4	-1.7	-2.6	-0.4	-0.6	-0.9	-1.0	-0.7	-2.0	-1.5	-1.5	0.3
Depression (Nagel 2018)	1.7	2.5	5.3	1.0	2.1	-1.4	-0.8	-1.3	-1.8	-1.6	-1.5	-2.0	-2.3	-1.8	-1.5	0.1
Intelligence (Savage-Jansen 2018)	1.5	4.5	13.0	-0.1	0.6	-2.6	-2.5	-0.0	-2.4	-2.4	-1.8	-1.9	-1.7	-2.0	-2.5	-3.6
Neuroticism (Nagel 2018)	0.6	1.5	3.6	0.5	1.1	-1.9	-1.2	0.2	-0.9	-0.9	-1.0	-0.8	-1.7	-1.7	-1.7	-1.1
Schizophrenia (2018)	0.3	0.5	2.8	-0.4	-1.3	-0.1	1.7	0.3	-0.1	0.5	0.0	0.1	0.7	-0.1	-0.2	-1.2
Schizophrenia vs Biploar Disorder	0.1	0.2	1.6	0.2	0.3	-0.1	-0.2	0.3	1.2	-0.0	0.1	0.3	-0.1	-0.2	0.2	0.4
Worry (Nagel 2018)	0.7	1.4	2.7	0.2	1.5	-1.4	-0.1	0.7	-1.2	-1.4	-1.0	-1.2	-1.1	-1.5	-1.3	-1.6
Alzheimer’s Disease (in mother)	0.2	0.2	0.6	-0.7	-0.5	-0.3	0.1	-0.6	0.1	0.3	0.4	0.5	0.2	0.0	-0.2	-0.7
Alzheimer’s Disease (in father)	1.3	1.4	6.0	0.5	0.8	-1.4	-1.2	-2.5	-0.0	-1.2	-0.9	-1.1	-1.1	-1.2	-1.5	0.1
Alzheimer’s Disease (including proxy)	0.8	1.2	4.9	0.2	0.4	-1.2	-1.6	-2.2	-0.4	-1.0	-0.9	-0.9	-1.0	-0.9	-1.3	-0.7
Crohns Disease (2017)	0.2	0.3	1.3	-0.6	1.1	-0.5	-0.0	0.4	-0.3	-0.6	-0.1	-0.4	-0.2	-0.2	-0.4	-1.1
Irritable Bowel Disease (IBD)	0.3	0.7	2.9	-1.0	1.1	-0.6	0.0	-0.5	-1.2	-0.8	-0.6	-0.8	-0.3	-0.6	-0.6	-1.7
Ulcerative Colitis (UC)	0.5	0.9	2.7	-0.8	1.1	-0.5	-0.0	-1.4	-1.6	-0.8	-0.9	-0.9	-0.4	-0.7	-0.6	-1.6
Major Depression (MDD)	2.5	3.1	5.5	1.4	0.8	-2.3	-1.8	-1.3	-2.1	-1.4	-1.5	-1.7	-2.0	-2.2	-2.3	-1.0
Reaction Time	1.0	1.9	4.5	2.1	1.2	-1.3	-1.2	-0.7	-1.6	-1.5	-1.1	-1.2	-1.5	-1.5	-1.3	-1.2
Verbal and Numeric Reasoning (VNR)	1.4	3.4	10.0	-0.2	0.9	-1.9	-3.2	-1.0	-2.4	-1.8	-1.6	-1.9	-2.1	-1.7	-1.8	-1.8
Breast Cancer	0.4	1.0	6.2	-0.7	-1.2	-1.0	-0.9	-0.8	0.4	-0.2	-0.8	-0.1	0.6	-0.1	-0.9	-2.5
Ovarian Cancer	0.2	0.2	0.5	-0.4	0.5	-0.7	-0.3	-0.3	-0.3	-0.3	-0.1	-0.2	-0.5	-0.6	-0.5	-0.7
Prostate Cancer	2.3	3.2	8.7	2.9	2.9	-1.0	-0.8	-0.5	-0.9	-2.1	-1.8	-2.2	-2.4	-1.6	-0.9	-0.1
Age at First Birth	0.4	0.6	3.5	-0.7	-0.5	-0.2	0.9	1.2	-0.2	-0.1	-0.6	-0.2	0.5	-0.1	-0.3	-1.9
Bipolar Disorder (2011)	0.3	0.3	0.9	0.9	-0.6	0.6	0.7	-0.4	-0.4	0.8	0.3	0.2	0.1	0.3	0.6	0.9
Body Mass Index (BMI) (2010)	6.0	8.2	17.0	2.2	2.8	-2.5	-4.1	-2.9	-3.0	-2.5	-3.3	-3.1	-3.3	-2.7	-2.6	-1.4
Coronary Artery Disease (CAD)	0.2	0.2	0.8	0.8	0.2	-0.3	0.1	-0.1	-0.2	-0.9	-0.2	-0.5	-0.5	-0.5	-0.3	0.2
Crohns Disease (2012)	0.5	0.8	4.0	-0.3	2.0	-0.6	-0.8	-0.3	-1.1	-0.8	-0.6	-1.2	-1.0	-0.6	-0.5	-0.7
Mean Putamen Volume	3.2	3.6	5.3	0.7	2.0	-2.1	-1.9	0.0	-2.2	-2.2	-2.3	-2.1	-2.1	-2.1	-1.9	-1.8
Fasting Glucose	0.2	0.3	2.7	-0.1	-0.4	-0.2	-1.6	-0.7	0.4	-0.3	0.2	-0.0	0.1	0.3	-0.1	0.1
HbA1C	1.2	1.3	3.7	-1.1	-1.3	0.2	0.6	-0.2	1.9	1.2	1.4	1.2	1.6	1.0	0.6	-1.0
HDL Cholesterol	2.5	4.2	8.6	1.7	1.9	-2.4	-0.6	0.6	-1.9	-2.9	-2.2	-2.3	-2.1	-2.5	-2.4	-1.9
LDL Cholesterol	0.2	0.4	2.7	0.3	0.3	-0.7	-0.3	-0.7	-0.4	-0.0	-0.6	-0.3	-0.0	-0.4	-0.6	-1.6
Lupus	0.3	0.4	1.0	0.2	0.8	-1.0	0.5	0.6	-0.4	-0.9	-0.2	0.0	-0.5	-0.7	-1.0	-0.8
Neuroticism (2016)	0.3	0.4	2.1	1.2	0.7	-0.4	-0.3	1.4	0.3	-0.2	0.2	0.1	-0.4	-0.3	-0.4	0.2
Primary Biliary Cirrhosis	0.3	0.5	1.5	-0.4	1.2	0.1	-0.7	-1.2	-0.2	0.0	-0.4	-0.7	-0.9	-0.2	0.3	1.0
Rheumatoid Arthritis	0.3	0.4	1.0	0.4	0.3	-0.7	0.4	0.0	-1.0	-1.0	-0.5	-0.8	-0.9	-0.8	-0.6	-0.6
Schizophrenia (2014)	0.3	0.7	4.0	-0.7	-1.3	-0.0	2.0	0.5	0.0	0.5	-0.1	-0.1	0.7	-0.1	-0.1	-1.2
Triglycerides	0.6	1.0	5.1	-1.1	0.5	0.9	-0.2	0.1	2.3	0.9	0.9	0.6	0.8	1.0	1.3	0.6
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.9	0.1	-0.3	0.4	-0.4	-0.4	0.2	0.6	0.5	0.5	-0.3	0.3	0.5	1.4
Ulcerative Colitis	0.2	0.3	0.7	-0.7	-0.7	0.6	0.2	-0.5	-0.3	0.8	0.2	0.3	0.6	0.6	0.6	-0.5
Blood Eosinophil Count	0.4	3.3	5.8	0.8	1.6	-2.1	-1.9	-1.5	-1.5	-2.1	-1.8	-1.9	-1.5	-1.8	-2.1	-2.4
Blood Platelet Count	0.5	5.8	15.1	2.0	1.7	-2.9	-2.8	-3.9	-0.9	-2.2	-2.1	-2.0	-2.0	-2.4	-2.7	-2.4
Blood Red Count	0.0	0.3	1.9	-1.4	0.2	-0.6	0.3	-0.4	-0.6	-0.3	0.3	0.2	-0.3	-0.3	-0.5	0.3
Blood White Count	0.2	1.7	11.5	-0.7	-0.1	-1.6	-1.7	-3.4	-0.2	-0.5	0.2	-0.2	-0.5	-0.6	-1.4	-1.5
Heel T-Score	0.9	6.8	23.7	0.9	2.7	-1.5	0.3	-4.9	-3.1	-2.0	-2.4	-4.3	-1.6	-1.8	-1.6	-2.8
BMI	4.8	28.1	42.4	3.5	4.0	-6.4	-5.4	-4.7	-4.5	-5.5	-5.7	-5.5	-4.8	-5.7	-6.5	-5.9
Height	0.2	4.4	28.7	-2.5	-2.6	0.7	0.2	5.4	0.9	2.0	1.4	1.8	1.7	1.2	0.4	0.0
Waist Hip Ratio (WHR)	0.3	1.2	5.2	0.9	-0.8	-1.4	-2.3	-1.1	0.4	-0.0	0.7	1.6	-0.8	-0.4	-1.0	0.5
Systolic Blood Pressure	0.4	2.0	4.3	-1.6	-0.9	1.5	0.4	2.1	1.6	1.3	1.7	1.3	1.6	1.7	1.5	0.2
Smoking Status	3.3	7.9	21.3	-2.0	-1.8	2.9	1.8	2.2	4.6	2.3	3.2	2.8	3.1	3.1	3.2	2.3
Allergy or Eczema	0.2	0.5	2.4	-0.1	0.4	-1.0	-0.1	-1.6	-0.8	-0.1	-0.4	-0.3	-0.6	-0.9	-1.0	-0.4
Cardiovascular Disease	0.1	0.3	1.3	-1.0	-0.2	-0.1	-1.1	-0.6	0.9	-0.1	0.6	0.6	0.3	0.3	0.2	-0.0
Hypothyroidism (self reported)	0.2	0.5	2.1	0.8	-1.4	-0.3	-0.3	0.3	0.2	0.5	0.1	0.8	0.6	0.4	-0.1	-1.4
Respiratory disease	0.8	1.8	3.2	0.7	1.8	-1.4	-1.4	-1.7	-1.0	-1.1	-1.3	-1.7	-1.7	-1.5	-1.3	-0.1
Type 2 Diabetes (T2D) (2018)	3.0	5.6	12.0	0.4	2.9	-2.6	-3.5	-1.5	-2.0	-2.6	-2.6	-2.4	-2.5	-2.4	-2.5	-1.2
Lung FEV1/FVC ratio	0.4	1.9	5.9	-1.6	-1.1	1.4	0.5	0.2	2.4	1.1	1.3	0.9	1.8	1.7	1.4	0.7
Lung FVC	0.9	4.7	9.7	-0.6	-3.1	2.4	-0.4	0.2	2.7	2.4	2.3	2.3	2.0	2.5	2.4	2.5
Neuroticism	0.4	1.0	2.9	0.0	0.4	-1.7	-1.5	1.0	-0.4	-0.5	-0.5	-0.0	-1.0	-1.2	-1.3	-1.4
Chronotype (morning person)	0.7	1.6	3.7	-1.5	-0.1	1.8	-0.0	-0.5	1.6	1.1	1.0	0.7	1.8	1.7	1.9	0.5
Hair Pigment	0.0	0.5	4.2	-0.4	0.0	0.7	-0.1	-1.0	0.3	-0.0	0.1	-0.4	-0.6	0.4	0.8	2.0
Tanning	0.2	2.9	5.4	-1.0	-1.4	1.5	2.1	2.3	1.6	2.1	1.9	2.0	1.7	1.4	1.6	0.7
Hand grip strength (left)	1.3	3.4	10.5	-2.4	-2.2	2.0	0.8	3.2	0.3	1.9	1.5	1.5	1.7	2.0	1.6	0.5
Number of treatments/medications taken	0.2	0.3	1.3	0.1	1.2	-0.4	0.3	0.2	0.3	-0.8	-0.1	0.0	-0.5	-0.4	-0.2	0.8
Average weekly spirits intake	0.6	0.7	2.1	-0.8	-0.9	1.2	1.4	0.9	0.0	0.4	0.2	0.2	1.2	1.0	1.0	-0.3
Sensitivity / hurt feelings	0.4	0.7	4.1	-0.5	-0.7	-0.0	1.0	2.0	0.8	0.9	0.8	1.0	0.3	0.1	0.0	-0.6
Frequency of depressed mood in last 2 weeks	0.8	1.1	1.8	0.5	1.1	-1.2	-0.3	-0.6	-1.3	-1.0	-1.1	-1.1	-1.0	-1.2	-1.3	-1.0
Hearing difficulty/problems: Yes	6.7	10.2	15.4	2.5	3.4	-3.7	-1.8	-1.3	-3.3	-3.6	-3.5	-3.5	-3.8	-3.9	-3.7	-2.2
Relative age of first facial hair	0.7	1.5	3.0	-0.6	-1.1	1.1	1.2	1.5	1.1	1.5	1.3	1.7	0.9	1.2	1.1	1.1
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	3.0	0.8	0.2	-1.2	-1.7	-0.2	-0.5	-0.5	-0.6	-0.2	-0.5	-0.8	-1.2	-1.0
Ever used hormone-replacement therapy (HRT)	0.4	0.5	3.6	-0.6	0.6	0.4	0.5	-0.3	0.9	0.1	-0.0	-0.2	-0.2	-0.2	0.5	1.9
Ever had hysterectomy (womb removed)	3.0	3.4	6.6	1.2	2.3	-1.9	-2.1	-2.1	-0.1	-2.6	-1.9	-2.2	-1.9	-1.8	-1.6	-0.8
Systolic blood pressure, automated reading	0.3	0.7	2.0	-1.4	-0.4	0.9	0.5	0.3	1.0	1.1	1.1	0.8	0.9	0.9	0.9	0.4
Eye problems/disorders: Diabetes related eye disease	2.0	2.1	5.6	-0.1	2.4	-1.3	-1.8	-1.1	-0.9	-1.5	-1.7	-1.6	-1.5	-1.5	-1.2	-1.2
Angina	1.8	2.4	4.2	2.0	0.7	-1.9	-1.2	-0.4	-1.5	-1.4	-1.8	-0.7	-1.4	-1.9	-1.8	-2.0
Medication for hormone replacement therapy	0.9	1.0	1.9	-0.6	-1.3	1.0	0.3	-0.6	0.7	1.4	1.2	1.1	0.8	1.0	1.0	1.4
Vitamin and mineral supplements	0.3	0.4	1.7	-0.4	-0.8	0.1	0.1	-0.6	0.9	0.5	0.9	1.3	0.3	0.5	0.4	0.4
Supplements: Zinc	0.4	0.4	2.1	-1.1	-0.5	-0.5	0.4	1.5	-0.2	-0.2	0.4	-0.0	0.1	-0.3	-0.6	-0.5
Medication: Co-codamol	2.4	2.8	7.4	2.7	1.0	-1.9	-1.3	-0.9	-2.2	-1.7	-1.6	-0.9	-1.9	-1.8	-1.9	-0.4
Medication: Metformin	3.6	5.0	8.0	0.9	2.6	-2.1	-2.8	-2.1	-2.0	-2.7	-2.4	-2.5	-2.7	-2.4	-2.1	-0.2
Diabetes (father)	0.6	0.7	2.6	-1.6	-1.2	0.3	0.3	0.7	0.7	0.9	0.8	0.8	1.0	0.7	0.3	-0.7
Diabetes (mother)	2.7	3.4	8.0	1.3	2.7	-1.7	-2.5	-1.9	-1.9	-1.1	-1.5	-1.4	-2.8	-1.8	-1.5	0.7
Severe depression (siblings)	0.2	0.3	1.4	0.3	0.4	-0.2	1.0	1.2	-0.1	-0.3	-0.1	-0.5	-0.2	-0.4	-0.4	-0.3
Pack years adult smoking proportion	0.5	0.8	2.7	0.9	-0.6	0.5	0.6	-0.2	1.6	1.2	0.8	1.1	1.3	1.0	0.5	0.0
Impedance of leg (right)	1.9	9.1	13.5	-2.3	-2.1	3.5	2.5	2.6	3.6	3.0	3.3	3.3	3.5	3.5	3.7	1.7
Leg fat-free mass (left)	1.8	9.3	16.6	1.1	2.1	-4.0	-3.3	-2.2	-2.9	-3.0	-3.3	-3.0	-2.8	-3.4	-4.1	-3.3
Trunk fat percentage	1.9	7.8	20.5	0.4	1.4	-3.8	-3.5	-2.3	-1.2	-2.9	-2.7	-2.2	-1.7	-2.8	-3.8	-4.5
Hand grip strength (right)	0.5	1.5	5.6	-2.4	-1.2	1.1	0.6	2.2	-0.5	1.3	0.6	0.6	1.0	1.1	0.8	0.2
Townsend deprivation index at recruitment	0.4	0.5	2.9	1.0	1.7	-0.5	0.4	0.4	-0.0	-0.9	-0.3	-0.9	-0.5	-0.5	-0.3	0.2
Current tobacco smoking	0.3	0.5	3.0	-0.6	0.6	0.4	0.0	-1.7	1.1	0.1	0.4	0.3	0.6	0.3	0.6	0.3
Average weekly fortified wine intake	0.3	0.4	1.0	-0.6	-0.2	0.6	0.2	-0.4	0.5	0.8	0.4	0.7	1.0	0.8	0.7	-0.5
Maternal smoking around birth	0.4	0.6	3.1	0.0	-0.2	0.3	-1.1	0.2	1.4	0.3	0.5	0.2	-0.4	0.2	0.6	1.8
Fed-up feelings	0.7	1.3	10.6	0.3	0.9	-1.1	-3.2	0.0	-0.2	-0.4	-0.5	-0.2	-1.4	-0.7	-0.9	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.7	3.5	6.8	1.0	2.6	-2.1	-1.2	-0.9	-1.4	-2.1	-2.0	-2.3	-2.0	-2.2	-2.1	-1.7
Relative age voice broke	0.4	0.6	2.1	-0.3	-1.1	0.9	1.4	0.1	0.6	0.8	0.4	0.7	1.0	0.8	0.9	0.5
Taking other prescription medications	2.2	3.4	5.9	1.6	2.2	-2.4	-0.7	-1.0	-1.8	-2.0	-1.7	-1.4	-1.7	-2.2	-2.3	-1.9
Age when periods started (menarche)	0.2	0.4	1.8	0.5	0.8	0.1	-0.1	-1.3	0.7	-0.5	-0.3	-0.9	-0.4	-0.0	0.2	0.8
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	2.1	-1.5	0.8	-0.1	1.2	0.2	0.8	-0.3	0.3	-0.1	-0.2	-0.4	0.1	0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	10.0	1.8	1.8	-1.1	-1.4	-3.2	-1.2	-1.1	-1.0	-2.2	-1.1	-1.0	-1.0	-1.1
Tinnitus: Yes, but not now, but have in the past	2.3	2.5	5.7	1.5	2.2	-1.2	-1.4	-1.3	-1.9	-1.5	-1.3	-1.3	-2.4	-1.8	-1.4	0.7
Qualifications: CSEs or equivalent	1.2	1.6	7.0	1.2	0.8	-1.3	-1.8	-2.6	-0.1	-1.0	-1.0	-0.5	-1.3	-1.1	-1.1	-0.7
Serious illness, injury or assault to yourself	0.2	0.3	0.6	-0.1	-0.3	0.6	0.8	0.3	0.8	0.2	0.3	0.3	0.6	0.7	0.6	0.5
High blood pressure	0.1	0.3	1.0	-0.6	0.2	0.1	-1.0	-0.9	0.9	-0.3	0.1	0.1	0.2	0.4	0.3	0.3
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.7	0.6	0.5	-0.5	0.2	-0.8	-0.8	-0.1	-0.4	-0.5	-0.4	-0.6	-0.8	-0.3
Multivitamins +/- minerals	0.1	0.1	0.4	0.6	0.2	0.0	0.0	0.6	-0.0	0.1	-0.2	-0.3	0.3	-0.1	-0.1	-0.3
Stomach or abdominal pain in last month	4.1	5.1	10.4	0.6	1.5	-2.2	-2.8	-3.2	-2.0	-2.3	-2.4	-2.4	-2.5	-2.5	-2.2	-1.6
Supplements: Glucosamine	0.9	1.1	4.2	2.1	-0.5	-0.8	-1.6	-1.8	-0.6	-0.8	-0.9	-0.4	-0.4	-0.7	-1.0	-0.8
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	3.9	1.1	0.8	-1.5	-1.6	-0.9	-1.7	-0.9	-1.4	-0.9	-0.9	-1.3	-1.7	-2.0
Medication: Atenolol	0.5	0.6	3.8	0.1	-1.9	0.6	0.3	1.0	-0.7	0.4	0.1	0.8	0.4	0.7	0.6	0.3
Medication: Levothyroxine sodium	1.3	2.2	4.8	-0.4	-2.2	1.5	1.4	0.7	1.7	1.6	1.2	1.7	2.0	1.8	1.6	0.1
Sitting height	1.7	12.1	20.9	-3.6	-3.8	3.7	2.7	2.9	2.7	4.6	3.7	3.5	3.6	3.6	3.5	2.9
Chronic bronchitis/emphysema (father)	0.3	0.4	2.3	-0.3	0.3	0.2	-0.4	-1.5	0.2	0.1	0.1	0.0	-0.4	0.2	0.2	1.5
High blood pressure (mother)	2.2	3.1	5.2	2.3	1.5	-1.4	-1.1	-1.8	-1.8	-2.1	-2.2	-2.2	-1.3	-1.6	-1.5	-1.7
Body mass index (BMI)	3.9	16.7	27.7	2.8	3.2	-5.3	-4.0	-3.7	-2.9	-4.5	-4.2	-3.9	-3.6	-4.4	-5.2	-4.6
Impedance of leg (left)	2.7	13.0	18.9	-2.8	-3.0	4.2	2.7	3.2	4.0	3.8	3.9	3.8	4.1	4.2	4.3	2.1
Leg predicted mass (left)	1.8	9.6	17.2	1.1	2.2	-4.0	-3.3	-2.1	-2.9	-3.1	-3.3	-3.1	-2.8	-3.5	-4.1	-3.4
Trunk fat mass	2.0	8.6	20.1	0.6	1.6	-4.1	-3.6	-2.2	-1.6	-3.0	-2.9	-2.4	-1.9	-3.0	-4.0	-4.5
Waist circumference	3.9	14.1	26.2	2.1	2.8	-5.1	-4.3	-3.2	-2.5	-4.0	-3.6	-3.2	-3.4	-4.0	-4.9	-4.3
Number of incorrect matches in round	0.3	0.5	3.4	1.0	0.3	0.5	1.8	0.1	0.1	0.4	0.5	0.3	0.4	-0.0	0.4	0.6
Past tobacco smoking	7.6	13.9	26.1	3.1	2.7	-4.0	-2.1	-4.0	-5.1	-3.0	-4.0	-3.4	-3.2	-4.0	-4.3	-4.5
Alcohol usually taken with meals	0.3	0.5	2.7	-1.6	-0.2	0.5	1.5	-0.3	-0.2	0.2	-0.3	-1.1	0.2	0.2	0.5	0.0
Nervous feelings	0.2	0.4	1.4	0.6	0.7	-0.7	0.1	0.5	-0.1	-0.6	-0.5	-0.8	-0.5	-0.7	-0.6	-1.2
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	2.7	0.8	1.6	-1.5	-0.0	-1.0	-0.7	-1.6	-1.6	-1.7	-1.1	-1.4	-1.6	-1.1
Hearing difficulty/problems with background noise	4.2	6.6	10.3	2.6	3.0	-2.9	-1.1	-1.3	-2.2	-3.0	-2.9	-2.9	-2.9	-3.2	-2.9	-1.3
Hair/balding pattern: Pattern 2	0.6	0.7	1.7	1.1	1.3	-0.7	0.0	-1.1	-0.4	-0.8	-0.7	-1.1	-0.6	-0.7	-0.7	-0.7
Had menopause	0.7	0.9	2.5	-0.5	1.6	-0.3	-0.2	-1.6	-0.5	-0.9	-1.1	-1.4	-0.9	-0.7	-0.3	0.7
Had other major operations	0.5	0.6	1.8	-0.3	-0.3	-1.2	-0.4	-1.3	0.1	-0.6	-0.3	-0.0	-0.1	-0.6	-1.2	-1.3
Forced vital capacity (FVC)	0.7	2.6	5.1	-1.1	-2.3	1.2	-1.0	1.2	2.3	2.1	1.8	1.8	1.4	1.7	1.1	1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.9	8.3	2.0	1.9	-1.3	-1.2	-2.9	-1.3	-1.5	-1.2	-2.4	-1.2	-1.3	-1.2	-1.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	1.3	0.3	1.1	-0.2	0.5	0.6	-0.7	0.1	0.2	-0.4	-0.5	-0.4	-0.1	0.2
Qualifications: None of the above	1.0	2.1	6.7	0.9	-0.2	1.9	1.2	-0.7	1.5	1.4	1.3	1.1	1.2	1.5	1.9	2.6
Financial difficulties in last 2 years	1.3	1.7	2.9	0.0	1.6	-1.5	-0.6	-0.6	-1.1	-1.4	-1.7	-1.4	-1.1	-1.6	-1.5	-1.5
Mouth/teeth dental problems	0.3	0.4	4.0	-2.0	-0.0	0.1	0.5	0.3	0.3	0.1	0.3	0.0	0.4	0.2	0.2	-0.7
Heart attack	1.0	1.3	4.5	-0.9	-1.1	0.9	1.6	2.1	1.3	0.8	0.9	1.0	1.1	0.8	0.9	0.8
Allergy	0.1	0.2	0.9	-0.1	-0.9	0.5	-0.4	0.6	0.1	0.2	0.2	0.5	0.3	0.5	0.5	0.2
Pain all over the body in last month	0.3	0.3	1.8	-0.7	0.6	0.0	-0.5	-1.3	0.2	-0.3	0.1	-0.3	-0.5	-0.2	0.0	0.9
Diabetes (self-reported)	1.9	3.0	6.6	0.3	1.8	-2.1	-2.6	-1.3	-1.0	-2.4	-1.9	-1.5	-1.6	-1.7	-1.9	-1.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.3	-0.1	-0.3	-0.3	-0.4	0.1	-0.6	0.2	-0.3	0.1	-0.2	-0.3	-0.5	-0.1
Medication: Ramipril	0.2	0.2	1.1	-0.9	0.1	-0.0	0.7	-0.0	-0.3	-0.4	-0.4	-0.1	0.5	-0.0	-0.2	-1.0
Medication: Simvastatin	2.0	2.9	5.8	-2.4	-0.9	2.1	2.1	2.1	1.2	0.9	1.2	1.4	1.7	1.8	2.1	1.2
Fluid intelligence score	0.6	1.3	5.4	-0.6	-0.3	-1.2	-2.3	-1.2	-1.2	-0.5	-0.7	-0.5	-0.9	-0.8	-1.2	-1.9
Illnesses of siblings	0.5	0.7	3.0	-0.7	-0.3	0.8	1.7	1.3	-0.1	1.0	1.0	0.5	0.4	0.3	0.7	0.6
Neuroticism score	1.0	2.0	5.0	0.8	1.5	-2.2	-1.3	0.4	-1.0	-1.3	-1.0	-0.8	-1.7	-1.9	-2.0	-1.6
Weight	2.4	11.6	21.7	1.4	2.1	-4.6	-3.8	-2.2	-2.5	-3.5	-3.5	-3.2	-2.8	-3.7	-4.7	-4.3
Impedance of arm (right)	0.2	1.1	5.1	-1.9	-0.8	0.4	0.3	2.3	1.1	0.3	0.8	0.8	1.0	0.5	0.4	-0.8
Arm fat percentage (right)	5.7	22.5	38.4	2.6	3.8	-6.2	-4.8	-3.3	-3.2	-5.4	-4.9	-4.5	-4.2	-5.3	-6.1	-5.7
Trunk fat-free mass	0.7	3.7	7.6	0.9	1.0	-2.6	-2.3	-0.8	-1.9	-1.7	-2.2	-1.9	-1.9	-2.2	-2.8	-2.0
Hip circumference	2.7	11.8	21.6	1.4	2.7	-4.4	-3.5	-2.2	-2.4	-3.5	-3.8	-3.5	-2.8	-3.7	-4.4	-4.7
Time employed in main current job	2.1	2.4	4.7	-1.2	-0.7	1.9	1.3	1.2	2.2	1.2	1.6	1.4	1.4	1.7	2.0	1.9
Alcohol intake versus 10 years previously	0.2	0.2	0.9	0.7	-0.9	0.1	0.5	-0.8	-0.2	-0.1	0.5	0.6	0.2	0.3	0.1	-0.0
Father’s age at death	1.4	1.9	5.7	-0.0	0.8	-0.2	-1.5	-2.1	-1.9	-1.1	-1.9	-2.4	-1.5	-0.7	-0.5	0.4
Worrier / anxious feelings	1.5	2.8	7.2	0.8	1.2	-2.1	-0.2	0.9	-1.7	-1.5	-1.7	-1.6	-1.3	-2.0	-2.2	-2.7
Frequency of tiredness / lethargy in last 2 weeks	11.3	18.4	24.2	3.2	4.2	-4.5	-4.2	-3.2	-4.6	-4.6	-4.9	-4.9	-4.6	-4.5	-4.7	-3.2
Falls in the last year	0.3	0.3	0.7	0.8	0.6	-0.3	0.2	-0.8	-0.7	-0.8	-0.3	-0.5	-0.7	-0.6	-0.3	0.6
Hair/balding pattern: Pattern 3	0.1	0.1	1.0	-0.4	-0.2	-0.4	-0.1	1.0	0.1	-0.1	0.2	0.0	-0.3	-0.3	-0.2	-0.1
Number of live births	0.1	0.2	0.8	-0.3	0.7	0.1	0.0	-0.8	0.5	-0.2	-0.2	-0.4	-0.3	-0.3	0.1	0.9
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	3.1	-0.8	-1.8	0.9	-1.0	0.4	1.8	1.8	1.4	1.3	1.1	1.4	0.8	0.6
Pulse rate	1.6	2.6	8.0	1.3	2.8	-1.8	-1.5	-1.0	-0.8	-1.7	-1.3	-1.8	-1.7	-1.8	-1.4	-1.1
Happiness	1.0	1.2	5.0	0.3	0.7	-1.5	-2.2	-0.9	-0.1	-0.7	-0.9	-0.6	-0.5	-0.7	-1.2	-1.8
Noisy workplace	7.4	9.1	12.7	3.3	3.2	-3.2	-2.4	-1.8	-3.0	-3.6	-3.4	-3.0	-3.2	-3.4	-3.5	-1.4
Qualifications: A levels/AS levels or equivalent	0.6	1.4	3.8	-1.2	-2.0	0.7	1.3	1.8	-0.7	1.1	0.9	1.1	1.1	1.0	0.4	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	3.5	-1.1	0.8	0.7	0.3	-0.3	-0.8	0.5	0.6	-0.1	-0.5	0.2	0.5	1.9
Mouth/teeth dental problems: Dentures	0.4	0.7	6.3	2.5	-0.1	-0.0	-0.6	-0.6	1.0	0.3	0.1	0.2	-0.1	-0.0	0.2	1.0
Asthma	0.4	0.8	1.5	-0.0	1.2	-1.2	-0.8	-0.8	-0.3	-0.8	-0.5	-1.0	-1.1	-1.1	-1.2	-0.0
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	3.6	-1.0	-1.0	1.1	1.1	0.7	1.9	1.2	1.2	1.3	1.3	1.3	1.3	1.2
Medication: Cholesterol lowering	1.9	3.0	7.8	-2.3	-1.1	1.7	1.7	2.8	0.6	1.5	1.8	2.2	1.3	1.5	1.9	1.0
Depression (self-reported)	1.8	2.1	4.5	0.4	1.8	-1.8	-0.6	-0.5	-1.1	-2.1	-1.5	-1.7	-1.6	-1.8	-1.8	-1.1
Medication: Lansoprazole	0.7	0.8	1.8	-0.4	1.2	-0.7	-0.1	-1.0	-0.1	-1.2	-1.3	-1.3	-0.8	-1.0	-0.9	-0.2
Prospective memory result	0.5	0.6	1.6	-0.2	-0.0	1.2	1.2	-0.4	0.5	0.4	0.0	0.0	0.6	1.0	1.3	1.3
Lung cancer (father)	0.6	0.7	3.4	0.9	1.6	0.0	-1.8	-0.7	0.6	-0.2	0.1	0.1	-0.7	-0.1	0.4	1.2
Illnesses of mother	1.1	1.3	4.4	-1.1	-0.2	0.8	1.3	2.1	1.3	0.9	1.1	1.3	1.0	0.9	0.8	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	3.7	-0.6	-1.8	0.9	-1.0	-0.1	1.9	1.8	1.2	1.0	1.2	1.4	0.7	0.6
Pulse wave Arterial Stiffness index	1.2	1.4	3.4	-0.2	-0.7	0.8	0.5	1.4	1.4	1.4	1.7	1.9	1.5	1.3	1.0	0.2
Impedance of arm (left)	0.5	2.4	5.9	-2.4	-1.8	1.2	0.7	2.1	1.5	1.4	1.6	1.7	1.8	1.4	1.2	-0.1
Arm fat mass (right)	4.4	18.1	31.7	2.0	3.1	-5.6	-4.3	-3.2	-3.0	-4.6	-4.5	-4.1	-3.7	-4.7	-5.6	-5.3
Trunk predicted mass	0.6	3.4	7.0	0.8	0.9	-2.5	-2.2	-0.6	-1.8	-1.5	-2.0	-1.7	-1.8	-2.1	-2.6	-1.9
Standing height	0.3	2.8	10.2	-3.2	-2.3	0.8	0.2	3.1	0.7	1.8	1.2	1.3	1.5	1.2	0.6	-0.0
Length of working week for main job	1.1	1.2	3.4	0.1	-1.4	0.9	-0.0	0.5	0.8	1.6	1.4	1.8	0.6	0.9	1.0	1.4
Exposure to tobacco smoke at home	0.5	0.6	3.8	-0.1	-0.0	-0.6	0.2	-0.6	-1.9	-0.4	-0.7	-0.6	-0.7	-0.6	-0.8	-0.8
Breastfed as a baby	0.2	0.2	0.6	-0.5	-0.3	-0.4	-0.0	-0.3	-0.6	-0.8	-0.3	-0.6	-0.5	-0.3	-0.3	-0.0
Tense / ‘highly strung’	1.0	1.6	7.8	-0.1	1.1	-1.4	0.5	-0.5	-0.7	-1.5	-1.4	-1.2	-0.2	-1.2	-1.4	-2.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	5.3	0.8	1.8	-2.3	-1.5	-0.3	-0.9	-1.9	-1.5	-1.8	-2.1	-2.1	-2.3	-1.2
Hair/balding pattern: Pattern 4	2.6	6.3	11.0	2.4	2.1	-2.6	-3.3	-1.7	-1.9	-2.7	-2.9	-2.6	-2.8	-2.8	-2.6	-1.5
Birth weight of first child	1.6	2.8	8.8	0.3	0.6	-2.5	-3.0	-2.1	-1.0	-1.0	-1.0	-0.7	-1.3	-1.6	-2.3	-2.0
Peak expiratory flow (PEF)	1.1	2.5	4.3	-0.9	-2.0	1.4	0.9	1.0	1.7	2.1	2.0	1.9	2.0	1.8	1.2	0.5
Pulse wave reflection index	0.9	1.1	3.0	0.1	-0.7	0.6	0.9	1.7	0.9	1.2	1.2	1.4	1.4	1.1	0.7	-0.0
Ever highly irritable/argumentative for 2 days	1.0	1.2	5.2	1.8	0.8	-0.3	1.2	2.3	-1.1	-0.6	-0.7	-1.0	-0.4	-0.7	-0.4	-0.9
Loud music exposure frequency	5.4	5.9	8.5	2.0	2.4	-2.7	-2.0	-1.4	-2.8	-2.2	-2.8	-2.3	-2.9	-2.9	-2.6	-1.9
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	2.8	-0.2	0.5	-1.1	0.0	0.2	-1.7	-0.8	-1.1	-0.8	-1.2	-1.2	-1.3	-0.9
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	1.4	-0.4	0.3	-0.1	-0.5	0.6	-1.2	-0.3	-0.5	-0.4	-0.6	-0.2	-0.3	-0.1
Blood clot in the leg (DVT)	0.3	0.4	1.7	-1.3	-0.5	0.6	0.8	-0.7	-0.2	0.5	0.7	0.5	0.3	0.5	0.6	0.5
Medication: Paracetamol	0.1	0.2	1.1	0.4	0.5	0.1	0.1	0.8	1.1	-0.2	0.5	0.2	0.2	0.4	0.5	0.3
Headache pain in last month	0.8	1.4	3.3	1.0	0.8	-1.2	-1.0	0.6	-1.8	-1.1	-1.3	-1.3	-1.7	-1.3	-1.2	-0.2
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	4.7	1.4	0.7	-1.4	-1.0	-2.2	-0.1	-0.7	-0.7	-1.0	-0.9	-1.1	-1.4	-0.5
Glaucoma (self-reported)	0.1	0.1	0.6	0.0	0.2	0.3	-0.4	-0.6	-0.0	0.1	0.2	0.2	-0.2	0.3	0.3	0.8
Gout (self-reported)	0.3	0.4	1.2	1.0	-0.6	0.7	0.4	0.2	-1.1	0.2	-0.1	-0.1	-0.3	0.2	0.6	1.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.7	0.4	-1.3	-0.0	0.6	0.6	0.6	0.5	0.2	0.7	0.9	0.5	0.0	-1.3
Medication: Amlodipine	1.3	1.9	3.6	-0.4	1.4	-1.5	-1.0	-0.9	-1.1	-1.9	-1.7	-1.4	-1.4	-1.5	-1.5	-1.2
Medication: Ventolin 100micrograms inhaler	1.3	1.7	3.2	0.1	0.8	-1.7	-1.8	-1.4	-0.2	-1.2	-1.6	-1.4	-1.0	-1.3	-1.7	-1.4
Birth weight	1.9	4.2	7.2	2.3	0.4	-2.3	-2.5	-2.4	-2.7	-1.4	-2.1	-1.6	-1.9	-2.0	-2.5	-1.3
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.8	-0.7	-0.2	0.2	0.7	0.9	0.4	0.0	0.5	0.3	0.3	-0.0	0.2	0.2
High blood pressure (siblings)	0.2	0.3	1.2	-0.5	-0.8	0.4	-0.4	-1.1	0.4	0.4	0.3	0.6	0.5	0.6	0.3	0.4
Forced vital capacity (FVC), Best measure	0.6	2.3	5.4	-0.9	-2.3	1.0	-1.3	0.8	2.3	2.1	1.5	1.5	1.4	1.6	0.8	0.9
Body fat percentage	2.5	10.0	21.1	1.3	2.2	-4.2	-3.8	-2.5	-1.7	-3.5	-3.1	-2.7	-2.2	-3.2	-4.1	-4.6
Leg fat percentage (right)	2.3	8.5	13.7	2.4	2.9	-3.7	-3.3	-2.8	-1.4	-3.3	-2.8	-2.5	-2.3	-2.9	-3.4	-3.4
Arm fat-free mass (right)	0.3	1.5	3.4	0.3	0.4	-1.7	-1.8	-1.2	-1.0	-0.8	-1.3	-1.1	-1.0	-1.2	-1.8	-1.3
Exposure to tobacco smoke outside home	0.5	0.7	1.6	1.0	1.2	-0.6	-0.4	-1.0	-0.0	-0.9	-1.3	-0.9	-1.0	-0.7	-0.4	-0.4
Comparative body size at age 10	0.9	2.4	7.0	0.6	0.5	-1.8	-1.4	-0.4	-1.7	-1.7	-2.2	-1.3	-0.9	-1.2	-1.8	-2.6
Number of full brothers	0.4	0.5	2.7	0.2	-0.5	-0.5	-0.4	0.3	1.6	-0.7	0.1	-0.0	0.8	0.1	-0.3	-1.3
Worry too long after embarrassment	0.2	0.3	0.9	-0.9	0.3	-0.7	0.1	0.1	-0.5	-0.0	-0.3	-0.7	-0.7	-0.8	-0.7	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.2	0.3	-0.0	-1.1	0.1	0.5	-0.5	-0.5	-0.2	0.0	-1.0	-1.0	-0.9	-0.5
Wheeze or whistling in the chest in last year	3.0	5.4	9.1	2.2	2.4	-3.0	-2.7	-1.7	-1.2	-2.3	-2.3	-2.1	-2.5	-2.7	-3.0	-1.2
Number of children fathered	0.5	0.6	3.3	-0.7	0.7	0.3	0.8	0.0	1.2	-0.3	0.6	0.0	-0.3	-0.1	0.5	1.8
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.2	3.5	-1.8	-1.1	1.6	0.3	0.5	1.7	1.4	1.6	1.6	1.4	1.9	1.8	1.4
Age at first live birth	0.6	1.0	4.6	0.1	-2.1	0.5	1.4	1.2	-1.1	1.1	0.9	1.0	0.7	0.5	0.3	-0.3
Pulse wave peak to peak time	1.1	1.2	3.2	-0.2	0.6	-0.8	-0.6	-1.1	-1.3	-1.3	-1.6	-1.8	-1.4	-1.2	-1.0	-0.3
Health satisfaction	0.6	0.8	3.0	-0.5	0.4	-1.2	-1.5	-0.4	-0.9	-0.5	-0.3	-0.1	-0.3	-0.5	-1.1	-1.7
Shortness of breath walking on level ground	2.8	3.3	5.9	1.8	1.2	-2.4	-0.7	-0.5	-1.9	-2.0	-2.0	-1.5	-1.7	-2.2	-2.4	-2.2
Qualifications: College or University degree	0.7	2.1	5.1	0.8	-0.1	-1.5	-1.6	-0.1	-2.0	-1.3	-1.9	-1.7	-1.1	-1.1	-1.6	-2.3
Eye problems/disorders: None of the above	3.8	4.4	7.2	-2.1	-2.5	2.1	2.0	0.8	1.7	2.3	2.3	2.4	2.7	2.3	2.0	1.1
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.2	1.6	1.1	-1.1	-1.8	-0.4	-1.1	-1.0	-0.8	-0.2	-1.2	-1.0	-1.0	-0.2
Emphysema/chronic bronchitis	0.6	0.6	1.9	1.4	1.4	-0.2	-1.2	-0.8	-0.5	-0.5	-0.8	-0.9	-0.6	-0.3	-0.2	0.3
Medication for pain relief, constipation, heartburn	0.4	0.7	4.0	-1.0	-2.0	0.6	-0.1	0.5	-0.1	1.1	0.5	0.7	0.9	0.8	0.3	-0.5
Neck or shoulder pain in last month	6.4	9.1	15.4	3.9	3.2	-3.3	-2.1	-3.3	-2.7	-2.5	-2.8	-2.6	-3.7	-3.6	-3.2	-0.7
Medication: Blood pressure	0.1	0.2	0.8	0.0	0.3	0.6	0.1	0.9	-0.3	-0.3	-0.6	-0.4	-0.1	0.2	0.6	0.7
Angina (self-reported)	1.8	2.4	4.3	2.1	0.8	-1.9	-1.4	-0.6	-1.3	-1.4	-1.8	-0.7	-1.4	-1.8	-1.8	-2.0
Migraine (self-reported)	0.7	0.9	2.5	-0.8	-0.3	1.0	1.6	0.8	0.7	1.0	1.0	0.6	0.7	1.0	1.1	1.1
Medication: Ibuprofen	0.6	0.7	3.1	-0.8	-0.3	0.6	0.2	-0.1	1.8	0.7	0.8	0.7	0.5	0.7	0.8	1.2
Medication: Allopurinol	0.5	0.6	1.4	0.2	-0.7	1.2	0.8	0.5	-0.3	0.8	0.7	0.5	0.3	0.9	1.2	1.2
Medication: Omeprazole	1.8	2.2	5.1	0.9	2.3	-1.7	-0.7	-1.6	-1.2	-1.8	-1.1	-1.1	-1.5	-1.7	-1.5	-1.3
Medication: Seretide 50 evohaler	0.1	0.1	0.8	0.9	0.3	-0.2	-0.2	0.0	0.3	-0.0	-0.0	-0.1	-0.2	-0.3	-0.2	-0.3
Mean time to correctly identify matches	1.7	3.3	6.2	2.5	1.5	-1.6	-1.1	-1.2	-2.3	-2.2	-1.8	-2.0	-1.9	-2.0	-1.6	-1.3
Heart disease (mother)	0.3	0.4	2.9	-0.1	-0.5	0.1	-0.6	-1.7	-1.0	-0.1	-0.1	-0.3	-0.6	-0.1	0.1	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	6.8	-1.0	-0.0	1.7	2.6	1.0	1.4	0.8	0.7	0.5	1.2	1.1	1.6	1.6
Whole body fat mass	2.5	10.6	20.6	1.2	2.0	-4.4	-3.7	-2.5	-2.0	-3.4	-3.3	-2.8	-2.4	-3.4	-4.4	-4.5
Leg fat mass (right)	2.7	10.4	18.2	2.0	2.6	-4.3	-3.6	-2.5	-2.2	-3.5	-3.2	-2.8	-2.6	-3.4	-4.1	-4.0
Arm predicted mass (right)	0.3	1.7	3.8	0.5	0.4	-1.8	-1.9	-1.3	-1.0	-0.8	-1.4	-1.2	-1.0	-1.3	-1.9	-1.4
Pulse rate, automated reading	3.3	10.8	23.8	2.6	3.2	-4.2	-4.9	-4.5	-1.9	-2.6	-2.4	-2.3	-3.8	-3.4	-3.6	-1.5
Alcohol intake frequency.	2.0	4.7	8.0	1.2	2.2	-2.4	-0.8	-2.0	-1.9	-2.8	-2.6	-2.3	-2.1	-2.5	-2.4	-2.1
Comparative height size at age 10	0.2	0.9	1.9	-0.2	0.7	-1.1	-0.9	-0.1	-0.7	-1.3	-1.4	-1.4	-0.7	-1.0	-1.1	-0.9
Number of full sisters	1.5	1.8	4.3	-0.4	-1.8	1.1	-0.2	0.8	2.1	1.4	1.4	1.6	1.7	1.5	1.1	1.0
Suffer from ‘nerves’	2.6	4.1	6.7	0.8	2.6	-2.2	-1.3	-1.4	-2.2	-2.4	-2.0	-2.3	-2.3	-2.3	-2.2	-1.5
Overall health rating	4.1	8.8	13.9	2.2	3.2	-3.7	-3.6	-2.7	-1.7	-3.2	-2.8	-2.6	-3.1	-3.3	-3.6	-1.9
Chest pain or discomfort	9.5	13.8	20.4	3.5	3.7	-4.4	-3.0	-2.2	-2.9	-4.3	-3.9	-4.0	-4.5	-4.5	-4.3	-1.6
Had major operations	0.9	1.1	2.5	-0.1	1.1	-1.4	0.8	-0.5	-1.4	-1.1	-0.4	-0.3	-1.3	-1.6	-1.3	-0.8
Age at last live birth	1.7	2.4	7.6	1.6	0.9	-1.7	-0.2	-0.1	-2.8	-1.4	-1.5	-1.3	-1.8	-1.9	-1.9	-1.3
Family relationship satisfaction	5.0	6.2	8.8	1.5	2.2	-3.0	-2.8	-2.9	-2.1	-2.2	-2.8	-2.3	-2.1	-2.4	-2.8	-2.7
Leg pain on walking	2.9	3.6	7.5	2.2	2.7	-1.7	-1.0	-1.2	-1.9	-2.2	-2.2	-2.3	-1.8	-1.9	-1.7	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.8	-1.4	-0.5	0.3	0.2	-0.6	0.4	0.9	1.1	0.9	0.1	0.3	0.4	1.1
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.4	0.8	0.5	-0.8	-1.0	-0.5	-1.2	-0.9	-0.8	-0.9	-1.2	-1.0	-0.9	-0.0
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	3.4	0.9	-1.8	0.5	0.7	1.5	1.2	1.4	1.4	1.8	1.1	0.8	0.5	0.4
Medication: Aspirin	0.1	0.1	0.5	0.3	0.1	-0.4	0.3	-0.3	-0.4	-0.2	0.0	0.4	0.1	-0.3	-0.4	-0.7
Supplements: Vitamin C	0.4	0.4	2.2	0.4	-0.0	-0.7	-0.1	1.2	-0.3	-0.5	-0.5	-0.7	0.1	-0.2	-0.6	-1.5
Knee pain experienced in last month	4.5	7.1	11.0	2.1	2.4	-2.9	-2.3	-3.3	-2.4	-2.8	-2.9	-2.7	-2.2	-2.8	-2.9	-2.6
Hypertension (Self-reported)	0.1	0.4	1.0	-0.8	0.6	0.4	-0.9	-0.7	1.0	-0.3	0.3	0.2	0.2	0.5	0.6	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.9	4.6	7.0	0.8	1.8	-2.4	-1.4	-1.4	-2.4	-2.3	-2.4	-2.3	-2.1	-2.5	-2.5	-2.6
Illnesses of father: Heart disease	0.2	0.3	1.0	-0.5	-0.7	-0.5	0.4	-0.1	0.1	0.4	0.4	1.0	0.3	-0.2	-0.5	-0.8
Illnesses of siblings: Diabetes	1.5	1.8	8.1	0.0	0.7	-1.6	-2.8	-1.0	-0.6	-1.2	-1.5	-1.2	-1.3	-1.1	-1.4	-1.0
Smoking status: Previous	7.7	11.5	25.2	-1.9	-2.3	3.4	2.4	5.0	4.7	2.6	3.6	2.9	2.7	3.3	3.7	4.0
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.9	-0.9	-0.3	-0.2	0.1	0.6	-0.2	0.5	0.2	-0.0	0.4	-0.1	-0.3	-1.0
Whole body fat-free mass	0.9	5.2	10.1	0.9	1.3	-3.0	-2.7	-1.3	-2.2	-2.1	-2.5	-2.2	-2.2	-2.5	-3.2	-2.4
Leg fat-free mass (right)	1.5	8.0	14.5	0.8	1.8	-3.6	-3.3	-1.9	-2.8	-2.7	-3.1	-2.9	-2.6	-3.1	-3.8	-3.1
Arm fat percentage (left)	4.6	18.5	32.3	2.3	3.3	-5.7	-4.6	-3.3	-3.0	-4.7	-4.3	-3.9	-3.7	-4.7	-5.5	-5.3
Average weekly red wine intake	0.9	1.3	7.1	-2.7	-1.0	1.1	0.7	0.3	0.1	1.2	1.1	0.8	0.6	0.9	1.1	1.0
Handedness (chirality/laterality): Left-handed	1.9	2.3	3.9	1.1	0.9	-1.9	-0.6	-0.9	-1.8	-1.6	-1.6	-1.3	-1.4	-1.9	-2.0	-1.9
Mood swings	1.8	3.3	6.0	1.4	1.9	-2.4	-1.6	-1.3	-1.5	-1.8	-1.6	-1.4	-2.1	-2.2	-2.2	-1.4
Loneliness, isolation	0.9	1.3	2.2	0.7	1.5	-1.3	-1.5	-0.7	-0.4	-1.0	-1.3	-1.3	-1.0	-1.1	-1.0	-1.4
Long-standing illness, disability or infirmity	1.7	2.6	6.4	1.1	1.3	-2.5	-1.1	-0.6	-0.7	-1.7	-1.6	-1.3	-1.4	-2.0	-2.4	-2.0
Ever had bowel cancer screening	0.4	0.5	2.2	-1.3	0.5	0.4	0.2	-0.7	-0.6	-0.0	0.2	-0.2	-0.7	-0.1	0.5	1.5
Diabetes diagnosed by doctor	3.2	5.3	10.8	0.4	2.4	-2.6	-3.3	-1.8	-1.9	-2.8	-2.6	-2.1	-2.2	-2.3	-2.5	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	6.1	6.5	10.9	-3.1	-1.1	2.8	2.5	1.6	2.0	2.7	3.1	2.4	2.0	2.6	2.9	3.3
Friendships satisfaction	1.1	1.4	3.6	1.2	0.9	-1.5	-1.6	-0.4	-0.7	-1.0	-1.1	-0.7	-0.8	-1.0	-1.4	-1.9
Qualifications: nursing, teaching	3.2	5.0	15.2	1.4	-0.0	-3.4	-1.6	-1.2	-1.6	-2.1	-2.0	-1.2	-1.5	-2.4	-3.3	-3.9
Commuting to job workplace: Walk	0.9	1.0	3.9	-1.2	-0.5	0.7	0.8	0.4	2.0	0.9	0.7	0.6	1.6	0.9	0.8	-0.7
Eye problems/disorders: Cataract	2.1	2.4	4.8	0.2	2.2	-1.8	-1.2	-0.6	-1.0	-1.9	-1.8	-1.8	-1.9	-1.7	-1.6	-1.1
Mouth/teeth dental problems: Mouth ulcers	1.6	2.5	5.0	-1.3	-1.5	1.7	2.2	0.9	2.1	1.4	1.5	1.3	1.5	1.5	1.6	1.6
Medication for cholesterol	0.3	0.4	1.8	0.4	0.2	-0.3	-0.1	1.3	-0.4	-0.1	-0.8	-0.8	-0.3	-0.6	-0.5	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	5.6	0.2	0.1	-0.9	-0.9	-2.4	-0.3	-0.6	-0.8	-0.5	-0.7	-1.0	-0.8	-0.2
Back pain experienced in last month	2.0	2.9	5.9	1.4	1.3	-2.4	-1.2	-0.6	-1.2	-1.5	-1.9	-1.5	-1.9	-2.3	-2.3	-1.7
Mineral and other dietary supplements	0.2	0.3	1.6	-0.5	0.4	0.4	0.9	1.3	0.0	0.4	0.5	0.2	-0.2	0.4	0.6	0.4
Breast cancer (self-reported)	0.2	0.3	0.6	0.4	0.1	0.4	0.8	0.4	0.3	0.6	0.7	0.6	0.5	0.6	0.4	0.3
Asthma (self-reported)	0.4	0.7	1.5	0.2	1.2	-1.2	-0.9	-0.7	-0.1	-0.8	-0.3	-0.8	-1.1	-1.1	-1.2	0.0
Osteoporosis (self-reported)	0.4	0.5	1.7	-0.1	-0.3	0.6	0.7	1.3	0.7	-0.1	0.7	0.5	0.9	0.7	0.8	-0.3
Osteoarthritis (self-reported)	1.5	2.0	3.3	1.6	1.0	-1.7	-0.5	-0.6	-1.5	-1.3	-1.4	-1.4	-1.3	-1.6	-1.8	-1.7
Medication: Aspirin	0.1	0.1	0.4	0.3	0.0	-0.3	0.2	-0.1	-0.5	-0.4	-0.3	0.2	-0.0	-0.3	-0.3	-0.6
Medication: Gliclazide	1.7	1.9	11.4	0.2	3.4	-1.1	-1.2	0.3	-0.5	-1.4	-1.0	-1.3	-1.6	-1.5	-0.9	0.6
Illnesses of father: None of the above (group 1)	7.0	8.6	13.5	-1.9	-2.1	3.6	2.4	2.4	2.3	3.4	3.6	3.0	2.8	3.3	3.7	3.0
Smoking status: Current	0.4	0.7	4.8	-0.8	0.6	0.4	-0.6	-2.2	1.0	0.1	0.3	0.2	0.5	0.4	0.7	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.8	-0.3	-1.6	1.2	0.1	-0.4	1.7	1.5	1.1	1.0	1.0	1.4	1.1	1.2
Whole body water mass	1.0	5.5	10.3	1.0	1.4	-3.1	-2.7	-1.4	-2.2	-2.1	-2.6	-2.3	-2.2	-2.6	-3.2	-2.5
Leg predicted mass (right)	1.5	8.0	14.4	0.8	1.8	-3.6	-3.3	-1.9	-2.7	-2.7	-3.1	-2.9	-2.6	-3.1	-3.8	-3.0
Arm fat mass (left)	4.0	16.3	29.8	1.8	2.6	-5.5	-4.3	-3.0	-2.8	-4.3	-4.2	-3.7	-3.4	-4.5	-5.4	-5.2
Number of self-reported non-cancer illnesses	0.7	1.1	2.3	1.3	1.5	-0.9	0.1	-0.5	-1.1	-1.5	-1.1	-1.0	-1.1	-1.2	-1.0	-0.2
Average weekly champagne plus white wine intake	0.2	0.3	0.7	-0.3	0.6	-0.7	0.6	-0.5	-0.4	-0.6	-0.6	-0.8	-0.5	-0.5	-0.6	-0.4
Miserableness	1.0	1.7	3.8	1.3	1.7	-1.4	-1.3	-0.2	-1.5	-0.8	-1.1	-0.7	-1.9	-1.6	-1.5	0.2
Guilty feelings	1.6	2.5	4.7	1.0	1.5	-2.0	-1.1	-0.0	-1.3	-1.7	-1.6	-1.8	-2.1	-2.2	-1.9	-0.8
Wears glasses or contact lenses	0.9	1.1	2.1	-0.6	-1.2	1.1	0.9	0.7	1.5	0.7	1.1	0.7	1.1	1.2	1.1	1.1
Ever taken oral contraceptive pill	0.2	0.2	1.4	-0.6	0.1	0.0	-0.9	1.2	0.3	-0.0	0.1	-0.1	-0.2	0.2	0.1	0.1
Hearing aid user	0.1	0.2	0.7	-0.0	0.2	-0.1	0.8	-0.1	-0.8	0.0	-0.1	0.1	-0.5	-0.3	0.0	0.6
Mother’s age at death	0.2	0.3	1.2	0.2	0.0	0.0	-0.6	-1.0	0.0	-0.2	-1.1	-0.9	-0.2	-0.4	0.0	0.3
Financial situation satisfaction	0.4	0.5	1.2	-0.4	0.1	0.9	0.7	1.1	0.3	1.1	0.5	0.5	0.6	0.8	1.0	0.7
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.2	-1.3	-0.6	1.4	1.5	1.0	0.3	1.1	1.3	0.8	1.1	1.2	1.4	0.7
Commuting to job workplace: Public transport	0.3	0.3	1.4	-1.2	-0.7	0.4	0.1	-0.4	0.7	0.2	0.0	-0.1	0.8	0.6	0.4	-0.5
Eye problems/disorders: Glaucoma	0.3	0.4	2.2	0.7	0.6	0.7	0.4	0.4	-0.5	0.2	0.1	-0.1	-0.3	0.3	0.6	1.5
Medication: Blood pressure	0.2	0.4	1.6	-0.7	0.4	-0.7	-1.1	-1.3	0.5	-0.7	-0.1	0.1	-0.0	-0.0	-0.4	-0.5
Pain type(s) experienced in last month: Hip pain	1.0	1.2	3.5	0.9	1.3	-1.1	-1.5	-1.9	-0.5	-0.9	-1.0	-1.0	-1.0	-1.1	-0.9	-0.6
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.5	-0.7	-0.8	0.3	-0.1	-0.6	1.2	0.5	0.6	0.6	0.7	0.3	0.2	0.7
High cholesterol (Self-reported)	3.1	5.4	10.1	-2.2	-2.1	2.4	3.2	3.1	1.9	1.6	2.4	2.4	2.2	2.2	2.4	1.5
Medication: Bendroflumethiazide	0.1	0.1	0.4	-0.1	-0.2	0.1	0.1	-0.5	0.6	-0.1	0.2	0.2	0.6	0.4	0.3	-0.3
Medication: Paracetamol	0.1	0.2	0.8	0.5	0.9	-0.2	-0.6	0.1	0.9	-0.4	0.2	-0.1	-0.3	0.0	0.2	0.3
Medication: Lisinopril	1.2	1.5	5.8	-1.9	-0.6	0.8	0.4	1.6	2.4	0.7	1.1	1.0	1.0	0.8	1.0	1.2
Medication: Atorvastatin	0.1	0.1	0.7	0.7	-0.1	-0.1	0.1	-0.3	-0.9	-0.2	0.4	0.5	-0.1	-0.1	-0.1	-0.0
Illnesses of father: High blood pressure	3.6	4.5	7.0	1.2	1.2	-2.6	-1.9	-2.0	-1.7	-2.6	-2.5	-2.0	-1.8	-2.3	-2.5	-2.3
Alcohol drinker status: Never	0.2	0.2	1.5	0.4	-0.2	-0.5	-0.3	-1.2	-0.6	-0.2	-0.1	0.1	-0.4	-0.2	-0.4	-0.1
Ever smoked	6.1	10.7	21.6	-3.3	-2.3	3.6	1.6	3.2	4.6	2.5	3.2	2.7	3.2	3.7	3.9	3.4
Basal metabolic rate	1.4	7.8	14.5	1.1	1.8	-3.7	-3.2	-1.7	-2.4	-2.7	-3.0	-2.7	-2.5	-3.1	-3.8	-3.2
Leg fat percentage (left)	2.0	7.1	11.6	2.0	2.4	-3.4	-3.3	-2.6	-1.3	-2.9	-2.5	-2.2	-2.1	-2.6	-3.2	-3.2
Arm fat-free mass (left)	1.0	5.1	9.3	1.1	1.5	-2.9	-2.5	-1.6	-1.9	-2.1	-2.6	-2.4	-2.1	-2.5	-3.0	-2.3
Number of operations (self-reported)	2.0	3.0	6.8	0.5	1.0	-2.6	-0.7	-1.3	-1.7	-1.9	-1.4	-1.1	-1.7	-2.3	-2.6	-2.0
Average weekly beer plus cider intake	3.0	4.4	13.1	-1.4	-1.2	2.5	0.3	1.4	3.6	1.9	2.0	1.6	2.1	2.5	2.7	2.0
Irritability	0.2	0.3	2.2	0.3	-0.3	-0.4	0.5	1.5	0.2	0.5	0.4	0.9	0.2	0.1	-0.3	-0.4
Risk taking	0.2	0.3	1.5	-0.7	0.0	0.8	0.2	0.4	0.2	0.1	-0.1	-0.3	-0.1	0.3	0.7	1.2
Ever had prostate specific antigen (PSA) test	0.4	0.5	2.2	0.0	-0.6	-0.6	0.1	1.5	-1.2	-0.3	0.4	0.4	-0.9	-0.6	-0.4	0.2
Fractured/broken bones in last 5 years	0.6	0.8	2.6	1.3	1.3	0.3	-0.1	-0.6	1.1	-1.0	-0.6	-1.1	-0.5	-0.1	0.4	1.6
Age started oral contraceptive pill	2.8	3.5	5.8	0.6	1.2	-2.1	-0.2	-0.6	-2.2	-2.1	-2.3	-2.4	-1.8	-2.2	-2.1	-2.4
Diastolic blood pressure, automated reading	0.4	1.1	3.0	-1.1	0.1	1.0	-0.3	-0.4	1.7	1.3	1.3	1.1	1.2	1.3	1.1	0.4
Ever depressed for a whole week	0.6	0.7	1.6	-0.7	-0.4	0.5	1.1	0.9	0.2	1.2	1.2	0.9	0.3	0.6	0.5	1.3
Unable to work because of sickness or disability	0.3	0.4	1.1	0.8	0.2	-1.0	-0.6	-0.4	0.7	-0.8	-0.2	-0.0	-0.5	-0.6	-0.8	0.3
Commuting to job workplace: Cycle	0.6	0.8	4.6	-0.3	-0.3	0.3	0.4	0.8	2.1	0.8	0.9	0.8	1.2	0.8	0.5	0.1
Myopia	0.3	0.4	2.2	-1.5	-0.7	0.4	0.5	-0.2	-0.4	0.4	0.5	0.7	0.5	0.5	0.4	0.1
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.7	0.5	-0.2	-0.0	0.8	0.8	-0.7	0.5	0.1	0.0	-0.1	-0.2	-0.2	-0.1
Cholesterol lowering medication	0.2	0.2	0.9	-0.1	0.9	-0.1	0.7	-0.4	-0.1	-0.9	-0.4	-0.5	-0.0	-0.2	-0.1	-0.1
Medication: Omeprazole (e.g. Zanprol)	3.0	3.6	8.1	1.4	2.8	-2.2	-0.9	-1.8	-1.4	-2.4	-1.7	-1.8	-1.9	-2.1	-1.9	-1.7
Pain experienced in last month	5.8	9.7	18.3	-2.3	-2.7	3.6	3.3	4.3	2.5	2.9	3.1	3.1	3.5	3.5	3.4	1.7
Supplements: Calcium	1.2	1.4	3.1	1.3	1.6	-1.0	-0.5	-0.0	-1.0	-1.8	-1.6	-1.4	-1.1	-1.1	-0.9	-0.3
Basal cell carcinoma (self-reported)	1.4	1.6	4.8	-1.1	-0.2	1.3	0.7	1.4	2.2	1.0	1.1	1.1	1.3	1.3	1.6	1.2
Heart attack/myocardial infarction (self-reported)	0.7	1.0	3.4	-0.8	-0.9	0.7	1.6	1.8	1.1	0.5	0.8	0.7	0.9	0.6	0.7	0.5
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	2.7	-1.6	-0.4	0.7	1.0	-0.5	-0.1	0.7	0.8	0.6	0.3	0.5	0.6	0.8
Heart disease (siblings)	0.4	0.5	2.1	-0.7	-0.3	0.5	-0.9	-0.5	1.4	0.4	0.3	0.5	0.6	0.8	0.7	0.6
Alcohol drinker status: Previous	0.8	0.9	2.0	-0.3	1.1	-0.8	-0.8	-0.8	-1.0	-0.9	-1.2	-0.9	-1.4	-1.1	-0.8	0.5
Pack years of smoking	0.5	0.7	2.2	1.1	-0.4	0.5	0.9	0.1	1.5	1.0	0.8	0.9	1.1	0.9	0.5	0.3
Impedance of whole body	1.7	8.4	11.2	-3.1	-2.7	3.1	2.0	3.0	3.2	2.9	3.1	3.0	3.4	3.2	3.2	1.2
Leg fat mass (left)	2.4	9.5	16.5	1.6	2.5	-4.1	-3.5	-2.5	-2.2	-3.2	-3.1	-2.8	-2.6	-3.2	-4.0	-3.8
Arm predicted mass (left)	1.0	5.2	9.4	1.1	1.5	-3.0	-2.6	-1.6	-1.9	-2.1	-2.5	-2.3	-2.2	-2.5	-3.1	-2.4