Hub : Genes

TMOD3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.171 0.067 6.1e-05 0.025 NA 0.053 NA 0.043 1.5e-02 NA 7.1e-04 NA 2.1e-03
2 GTEx Skin Not Sun Exposed Suprapubic 0.054 0.023 1.6e-03 0.065 NA 0.075 NA 0.066 1.8e-04 NA 6.4e-05 NA 1.7e-04
3 GTEx Skin Sun Exposed Lower leg 0.070 0.027 4.2e-05 0.067 NA 0.063 NA 0.060 3.1e-06 NA 6.0e-06 NA 9.8e-06
4 GTEx Testis 0.141 0.051 5.9e-05 0.108 NA 0.159 NA 0.141 1.6e-05 NA 1.5e-07 NA 8.1e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.6 0.9 1.6 0.2 -1.1 -1.0 -1.2
Bipolar Disorder or Schizophrenia 0.7 1.6 5.0 -0.4 -1.0 -0.6 -2.2
Depressed Affect (Nagel 2018) 1.2 2.5 3.5 -0.9 1.6 1.9 1.8
Depression (Nagel 2018) 1.8 2.7 4.5 -1.2 1.6 1.5 2.1
Intelligence (Savage-Jansen 2018) 1.9 5.7 7.6 -2.8 2.5 2.7 1.3
Neuroticism (Nagel 2018) 1.2 2.8 4.3 -1.0 1.7 2.1 1.7
Schizophrenia (2018) 0.5 1.0 3.5 -0.6 -0.3 -0.0 -1.9
Schizophrenia vs Biploar Disorder 0.0 0.0 0.0 -0.1 -0.0 0.1 -0.0
Worry (Nagel 2018) 0.9 1.8 2.4 -1.0 1.2 1.6 1.5
Alzheimer’s Disease (in mother) 0.0 0.1 0.2 -0.1 0.2 0.4 -0.0
Alzheimer’s Disease (in father) 1.3 1.4 2.2 -0.4 1.4 1.5 1.1
Alzheimer’s Disease (including proxy) 0.7 1.0 1.7 -0.6 1.2 1.3 0.7
Crohns Disease (2017) 0.1 0.3 0.5 -0.7 0.3 0.7 0.0
Irritable Bowel Disease (IBD) 0.3 0.7 2.3 -1.5 0.3 0.7 0.1
Ulcerative Colitis (UC) 0.4 0.8 2.6 -1.6 0.3 0.5 0.4
Major Depression (MDD) 3.3 4.0 5.8 -1.5 2.3 2.4 1.7
Reaction Time 1.1 2.0 3.1 -1.0 1.5 1.3 1.8
Verbal and Numeric Reasoning (VNR) 1.5 3.5 4.3 -2.1 1.9 2.0 1.5
Breast Cancer 0.1 0.3 0.8 -0.0 0.5 0.9 -0.1
Ovarian Cancer 0.3 0.4 0.5 -0.7 0.6 0.7 0.7
Prostate Cancer 2.1 2.9 5.9 -1.7 1.5 1.0 2.4
Age at First Birth 0.0 0.0 0.1 -0.0 0.1 -0.0 0.3
Bipolar Disorder (2011) 0.3 0.3 0.6 0.3 -0.7 -0.8 -0.1
Body Mass Index (BMI) (2010) 4.6 6.3 7.1 -2.7 2.5 2.4 2.4
Coronary Artery Disease (CAD) 0.2 0.3 0.6 -0.8 0.5 0.4 0.3
Crohns Disease (2012) 0.3 0.5 0.6 -0.8 0.7 0.7 0.6
Mean Putamen Volume 4.2 4.8 6.0 -2.0 2.2 2.1 2.4
Fasting Glucose 0.1 0.1 0.1 0.2 0.2 0.3 -0.3
HbA1C 0.6 0.6 2.0 0.4 -0.6 -0.2 -1.4
HDL Cholesterol 3.6 6.0 8.1 -2.2 2.3 2.4 2.8
LDL Cholesterol 0.3 0.5 0.8 -0.6 0.5 0.7 0.9
Lupus 0.4 0.6 1.2 -0.9 0.7 1.1 0.3
Neuroticism (2016) 0.2 0.3 0.8 0.5 0.3 0.5 0.9
Primary Biliary Cirrhosis 0.4 0.6 2.0 0.4 -0.2 -0.2 1.4
Rheumatoid Arthritis 0.9 1.2 2.8 -1.1 0.6 0.7 1.7
Schizophrenia (2014) 0.3 0.7 2.6 -0.5 -0.4 -0.1 -1.6
Triglycerides 0.5 0.9 1.3 1.1 -1.1 -0.9 -0.3
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.2 0.4 -0.3 -0.2 -0.2
Ulcerative Colitis 0.3 0.4 0.7 -0.2 -0.8 -0.6 -0.8
Blood Eosinophil Count 0.5 4.0 4.7 -1.8 2.1 2.2 2.0
Blood Platelet Count 0.6 6.6 10.6 -2.0 3.3 2.9 1.7
Blood Red Count 0.0 0.4 0.6 0.4 0.6 0.7 0.8
Blood White Count 0.2 1.6 3.5 -0.6 1.2 1.9 1.0
Heel T-Score 0.4 2.9 6.3 -2.5 1.9 1.3 0.0
BMI 6.0 34.9 41.9 -5.8 6.3 6.5 5.0
Height 0.1 1.4 2.0 1.3 -1.1 -0.9 -1.4
Waist Hip Ratio (WHR) 0.3 1.5 2.9 0.7 1.2 1.7 1.1
Systolic Blood Pressure 0.5 2.3 3.9 1.7 -2.0 -1.4 -0.7
Smoking Status 3.4 8.2 11.7 3.4 -3.1 -2.7 -1.9
Allergy or Eczema 0.2 0.6 1.0 -0.5 0.9 1.0 0.4
Cardiovascular Disease 0.0 0.1 0.2 0.5 -0.1 0.2 0.2
Hypothyroidism (self reported) 0.0 0.1 0.1 -0.3 0.2 0.3 -0.1
Respiratory disease 0.9 2.0 2.8 -1.1 1.4 1.4 1.7
Type 2 Diabetes (T2D) (2018) 3.0 5.7 7.0 -2.2 2.6 2.6 2.0
Lung FEV1/FVC ratio 0.4 2.1 3.0 1.7 -1.5 -1.3 -1.1
Lung FVC 1.0 5.2 6.6 2.6 -2.3 -2.3 -1.9
Neuroticism 0.8 1.9 3.5 -0.9 1.4 1.9 1.1
Chronotype (morning person) 1.0 2.3 3.4 1.5 -1.9 -1.8 -0.2
Hair Pigment 0.0 0.5 0.6 0.7 -0.8 -0.7 0.6
Tanning 0.2 2.0 2.9 1.4 -1.7 -1.5 -1.0
Hand grip strength (left) 1.4 3.8 4.7 1.5 -2.2 -2.0 -2.0
Number of treatments/medications taken 0.3 0.5 1.4 0.0 0.5 0.4 1.2
Average weekly spirits intake 1.1 1.3 2.1 0.4 -1.3 -1.4 -1.2
Sensitivity / hurt feelings 0.0 0.0 0.0 0.1 -0.2 0.1 0.0
Frequency of depressed mood in last 2 weeks 1.0 1.4 1.8 -0.9 1.2 1.2 1.3
Hearing difficulty/problems: Yes 8.9 13.5 15.8 -4.0 3.7 3.7 3.3
Relative age of first facial hair 0.6 1.2 1.3 1.1 -1.1 -1.1 -1.2
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 1.4 -0.7 1.0 1.2 0.1
Ever used hormone-replacement therapy (HRT) 0.2 0.3 0.4 0.6 -0.5 -0.6 0.5
Ever had hysterectomy (womb removed) 3.6 4.0 5.3 -2.1 1.7 1.9 2.3
Systolic blood pressure, automated reading 0.3 0.8 1.7 0.8 -1.3 -0.8 -0.7
Eye problems/disorders: Diabetes related eye disease 1.9 2.1 3.5 -0.8 1.6 1.3 1.9
Angina 2.6 3.5 4.5 -2.1 2.1 1.9 1.2
Medication for hormone replacement therapy 0.7 0.8 0.9 1.0 -0.9 -1.0 -0.6
Vitamin and mineral supplements 0.2 0.2 0.7 0.1 -0.3 -0.1 -0.9
Supplements: Zinc 0.1 0.1 0.4 -0.0 0.4 0.6 -0.0
Medication: Co-codamol 2.5 2.9 3.8 -1.6 1.9 1.8 1.4
Medication: Metformin 3.2 4.6 6.8 -2.1 2.6 2.2 1.6
Diabetes (father) 0.1 0.1 0.1 0.4 -0.3 -0.2 0.2
Diabetes (mother) 2.5 3.2 4.1 -1.8 1.6 1.7 2.0
Severe depression (siblings) 0.1 0.1 0.4 -0.7 0.0 0.1 -0.2
Pack years adult smoking proportion 0.4 0.6 1.5 1.2 -0.3 -0.5 -0.7
Impedance of leg (right) 2.1 10.4 13.6 3.5 -3.7 -3.5 -1.9
Leg fat-free mass (left) 2.2 11.7 15.3 -3.2 3.9 3.9 2.4
Trunk fat percentage 2.6 10.5 15.1 -3.1 3.5 3.9 2.2
Hand grip strength (right) 0.5 1.3 1.8 0.8 -1.3 -1.2 -1.2
Townsend deprivation index at recruitment 0.4 0.5 1.4 0.3 0.5 0.6 1.2
Current tobacco smoking 0.1 0.2 0.3 0.5 -0.4 -0.5 0.2
Average weekly fortified wine intake 0.9 1.0 3.4 0.0 -0.5 -0.6 -1.9
Maternal smoking around birth 0.5 0.7 2.4 1.6 -0.3 -0.2 0.4
Fed-up feelings 0.8 1.4 2.6 0.0 1.0 1.3 1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 3.9 5.2 8.1 -1.8 2.2 2.2 2.9
Relative age voice broke 0.6 0.9 1.5 0.6 -0.8 -1.0 -1.2
Taking other prescription medications 3.5 5.4 6.1 -2.5 2.3 2.5 2.0
Age when periods started (menarche) 0.1 0.3 1.1 0.5 0.1 -0.2 1.0
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 1.2 -0.1 0.1 0.2 1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.2 1.7 -1.3 1.3 1.1 0.6
Tinnitus: Yes, but not now, but have in the past 1.9 2.1 2.5 -1.5 1.3 1.3 1.6
Qualifications: CSEs or equivalent 1.2 1.7 2.2 -1.0 1.5 1.5 1.1
Serious illness, injury or assault to yourself 0.2 0.3 0.5 0.5 -0.5 -0.7 -0.2
High blood pressure 0.0 0.0 0.1 0.3 -0.0 0.0 0.2
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.4 -0.7 0.6 0.5 0.0
Multivitamins +/- minerals 0.0 0.0 0.1 0.1 -0.0 -0.1 0.2
Stomach or abdominal pain in last month 4.6 5.7 8.4 -2.1 2.3 2.1 2.9
Supplements: Glucosamine 0.2 0.3 0.5 -0.2 0.7 0.7 0.6
Diverticular disease/diverticulitis (self-reported) 1.6 1.9 2.2 -1.3 1.5 1.5 1.2
Medication: Atenolol 0.7 0.9 2.4 -0.3 -0.7 -0.7 -1.5
Medication: Levothyroxine sodium 1.1 1.9 2.2 1.4 -1.4 -1.5 -1.2
Sitting height 1.9 13.7 15.8 3.2 -3.7 -3.9 -4.0
Chronic bronchitis/emphysema (father) 0.1 0.1 0.5 0.7 -0.1 -0.2 0.2
High blood pressure (mother) 1.6 2.2 4.1 -2.0 1.6 1.3 0.6
Body mass index (BMI) 5.3 22.7 28.5 -4.7 5.1 5.3 3.8
Impedance of leg (left) 3.2 15.5 19.0 4.1 -4.4 -4.2 -3.0
Leg predicted mass (left) 2.3 12.0 15.7 -3.3 4.0 4.0 2.4
Trunk fat mass 2.8 11.8 16.8 -3.3 3.8 4.1 2.4
Waist circumference 5.7 20.9 28.4 -4.1 5.0 5.3 3.6
Number of incorrect matches in round 0.2 0.3 0.5 0.7 -0.4 -0.5 -0.5
Past tobacco smoking 8.2 15.1 22.8 -4.8 4.1 3.7 2.6
Alcohol usually taken with meals 0.1 0.1 0.4 -0.2 -0.4 -0.6 0.1
Nervous feelings 0.3 0.6 1.3 -0.5 0.5 0.8 1.1
Frequency of tenseness / restlessness in last 2 weeks 1.4 2.2 3.5 -1.1 1.5 1.4 1.9
Hearing difficulty/problems with background noise 5.4 8.6 12.2 -3.5 3.1 2.9 2.1
Hair/balding pattern: Pattern 2 0.4 0.6 0.9 -1.0 0.6 0.7 0.7
Had menopause 0.2 0.3 0.6 -0.8 0.3 0.2 0.7
Had other major operations 0.6 0.8 1.5 -0.7 1.1 1.2 0.1
Forced vital capacity (FVC) 0.6 2.4 4.8 2.2 -1.3 -1.0 -1.5
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.8 2.4 -1.5 1.6 1.3 1.0
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.9 -0.4 -0.0 0.3 0.9
Qualifications: None of the above 1.3 2.8 3.6 1.7 -1.6 -1.9 -1.4
Financial difficulties in last 2 years 1.3 1.7 2.5 -1.6 1.4 1.4 0.8
Mouth/teeth dental problems 0.0 0.0 0.0 0.1 -0.0 0.0 0.1
Heart attack 0.6 0.8 1.0 0.9 -0.7 -0.9 -1.0
Allergy 0.1 0.3 0.4 0.1 -0.7 -0.7 -0.5
Pain all over the body in last month 0.1 0.1 0.5 0.1 -0.1 0.0 0.7
Diabetes (self-reported) 2.5 3.8 5.1 -1.7 2.3 2.1 1.7
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.1 -0.3 0.4 0.4 -0.4
Medication: Ramipril 0.0 0.0 0.0 0.2 0.1 -0.0 0.0
Medication: Simvastatin 2.4 3.6 5.1 1.8 -1.8 -2.3 -1.6
Fluid intelligence score 0.6 1.2 1.9 -1.2 1.1 1.4 0.3
Illnesses of siblings 0.3 0.5 0.7 0.8 -0.8 -0.7 -0.2
Neuroticism score 2.0 4.1 5.9 -1.5 2.1 2.4 2.1
Weight 3.3 16.1 21.6 -3.8 4.5 4.7 3.0
Impedance of arm (right) 0.1 0.3 0.6 0.7 -0.7 -0.4 -0.3
Arm fat percentage (right) 7.9 31.3 39.2 -5.4 5.9 6.3 4.7
Trunk fat-free mass 0.8 4.9 7.2 -1.9 2.7 2.6 1.5
Hip circumference 3.6 15.6 19.6 -4.2 4.3 4.4 2.6
Time employed in main current job 2.5 2.9 4.0 1.6 -2.0 -1.8 -1.3
Alcohol intake versus 10 years previously 0.1 0.1 0.2 -0.5 -0.1 -0.1 -0.3
Father’s age at death 0.3 0.5 1.0 -0.8 0.5 0.1 1.0
Worrier / anxious feelings 1.7 3.3 4.7 -1.7 1.8 2.2 1.5
Frequency of tiredness / lethargy in last 2 weeks 12.3 20.0 22.8 -4.6 4.8 4.4 4.1
Falls in the last year 0.2 0.3 0.9 -0.1 0.4 0.2 1.0
Hair/balding pattern: Pattern 3 0.1 0.1 0.1 -0.2 0.4 0.4 0.3
Number of live births 0.0 0.1 0.2 0.4 0.1 -0.1 -0.0
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 3.0 1.7 -0.9 -0.7 -1.2
Pulse rate 2.1 3.6 5.1 -1.5 1.8 2.0 2.3
Happiness 1.2 1.4 2.6 -0.7 1.2 1.6 1.1
Noisy workplace 7.3 9.0 10.3 -2.8 3.2 3.1 2.9
Qualifications: A levels/AS levels or equivalent 0.5 1.1 3.5 0.1 -0.6 -0.7 -1.9
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 0.6 0.2 -0.8 -0.6 -0.3
Mouth/teeth dental problems: Dentures 0.0 0.0 0.0 0.0 0.0 -0.0 -0.0
Asthma 0.6 1.2 1.9 -0.8 1.2 1.4 0.8
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.7 2.1 1.4 -1.2 -1.1 -1.5
Medication: Cholesterol lowering 1.5 2.3 2.8 1.4 -1.6 -1.7 -1.3
Depression (self-reported) 2.7 3.2 4.2 -1.6 1.8 1.7 2.0
Medication: Lansoprazole 0.9 1.0 2.6 -0.6 0.8 0.7 1.6
Prospective memory result 0.8 1.0 1.8 1.0 -1.0 -1.4 0.2
Lung cancer (father) 0.2 0.2 0.5 0.4 0.4 0.1 0.7
Illnesses of mother 0.6 0.8 1.9 1.4 -0.8 -0.7 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 2.6 1.6 -0.9 -0.7 -0.8
Pulse wave Arterial Stiffness index 1.2 1.3 2.0 1.4 -1.1 -0.8 -1.2
Impedance of arm (left) 0.4 1.9 2.5 1.5 -1.6 -1.2 -1.1
Arm fat mass (right) 6.1 25.0 31.8 -4.9 5.4 5.6 4.0
Trunk predicted mass 0.8 4.4 6.5 -1.8 2.6 2.5 1.4
Standing height 0.2 1.7 2.6 1.6 -1.0 -1.0 -1.5
Length of working week for main job 0.5 0.6 0.8 0.9 -0.9 -0.7 -0.4
Exposure to tobacco smoke at home 0.5 0.6 1.1 -1.1 0.7 0.7 0.1
Breastfed as a baby 0.2 0.3 0.6 -0.8 0.5 0.5 -0.1
Tense / ‘highly strung’ 1.1 1.8 2.0 -1.2 1.4 1.3 1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 3.7 5.6 8.8 -1.6 2.1 2.5 3.0
Hair/balding pattern: Pattern 4 2.8 6.9 7.1 -2.5 2.7 2.6 2.7
Birth weight of first child 2.1 3.9 8.1 -1.1 2.3 2.9 1.0
Peak expiratory flow (PEF) 1.0 2.3 3.9 1.4 -1.3 -1.2 -2.0
Pulse wave reflection index 1.2 1.5 3.4 1.0 -1.1 -0.7 -1.8
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.4 -0.6 0.5 0.2 0.5
Loud music exposure frequency 5.9 6.4 8.7 -3.0 2.6 2.5 2.0
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 3.6 -1.9 1.0 1.0 0.5
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.3 -0.5 0.1 0.1 -0.2
Blood clot in the leg (DVT) 0.2 0.3 0.7 0.8 -0.4 -0.4 -0.2
Medication: Paracetamol 0.2 0.4 1.1 0.6 -0.3 -0.0 1.1
Headache pain in last month 1.2 2.1 4.4 -1.0 1.2 1.2 2.1
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 1.9 -1.0 1.3 1.4 0.9
Glaucoma (self-reported) 0.1 0.1 0.1 0.3 -0.2 -0.3 -0.2
Gout (self-reported) 0.3 0.4 0.6 -0.5 -0.6 -0.8 -0.7
Hypothyroidism/myxoedema (self-reported) 0.0 0.0 0.2 0.0 0.0 0.0 -0.4
Medication: Amlodipine 2.2 3.1 5.2 -1.5 1.6 1.5 2.3
Medication: Ventolin 100micrograms inhaler 1.6 2.0 2.9 -1.0 1.6 1.7 1.4
Birth weight 1.4 2.9 4.6 -1.6 2.1 2.2 0.4
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.2 0.2 -0.2 -0.3 -0.5
High blood pressure (siblings) 0.2 0.3 0.9 0.2 -0.3 -0.4 -0.9
Forced vital capacity (FVC), Best measure 0.5 1.8 3.9 2.0 -1.2 -0.8 -1.2
Body fat percentage 3.5 13.8 18.7 -3.6 4.0 4.3 2.8
Leg fat percentage (right) 3.2 11.6 14.6 -3.1 3.5 3.8 3.1
Arm fat-free mass (right) 0.4 1.9 3.1 -1.1 1.8 1.7 0.6
Exposure to tobacco smoke outside home 0.7 0.9 2.6 -0.7 0.6 0.5 1.6
Comparative body size at age 10 1.1 3.0 5.9 -2.4 1.8 1.7 -0.2
Number of full brothers 0.2 0.3 0.5 0.4 0.7 0.6 0.2
Worry too long after embarrassment 0.2 0.4 0.7 -0.9 0.7 0.7 0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.4 2.8 -0.7 1.0 1.2 1.7
Wheeze or whistling in the chest in last year 3.9 7.0 9.7 -1.8 3.1 3.1 2.3
Number of children fathered 0.0 0.1 0.1 -0.0 -0.2 -0.2 0.4
Reason for reducing amount of alcohol drunk: Health precaution 2.4 2.8 3.6 1.9 -1.6 -1.6 -1.5
Age at first live birth 0.5 0.8 2.8 0.1 -0.5 -0.6 -1.7
Pulse wave peak to peak time 1.0 1.2 1.7 -1.3 1.1 0.7 1.2
Health satisfaction 0.9 1.2 1.9 -1.2 1.0 1.4 0.7
Shortness of breath walking on level ground 4.0 4.8 5.8 -2.4 2.3 2.4 1.5
Qualifications: College or University degree 0.6 1.8 2.7 -1.6 1.6 1.4 0.1
Eye problems/disorders: None of the above 4.8 5.5 8.2 1.8 -2.5 -2.2 -2.9
Mouth/teeth dental problems: Loose teeth 0.7 0.9 1.2 -0.8 1.0 1.1 0.8
Emphysema/chronic bronchitis 0.4 0.5 1.8 0.1 0.4 0.2 1.3
Medication for pain relief, constipation, heartburn 0.5 0.8 2.0 0.5 -0.9 -0.6 -1.4
Neck or shoulder pain in last month 7.2 10.2 12.0 -2.6 3.4 3.2 3.5
Medication: Blood pressure 0.1 0.3 0.6 0.4 -0.6 -0.7 -0.0
Angina (self-reported) 2.5 3.3 4.4 -1.9 2.1 1.8 1.3
Migraine (self-reported) 0.8 0.9 1.5 0.5 -1.2 -1.2 -0.8
Medication: Ibuprofen 0.4 0.5 0.9 1.0 -0.6 -0.5 -0.8
Medication: Allopurinol 0.9 1.1 1.5 0.4 -1.2 -1.2 -1.2
Medication: Omeprazole 2.8 3.3 4.1 -1.7 2.0 1.7 1.9
Medication: Seretide 50 evohaler 0.1 0.1 0.1 -0.0 0.3 0.2 0.3
Mean time to correctly identify matches 1.9 3.6 5.6 -1.6 1.9 1.6 2.4
Heart disease (mother) 0.1 0.1 0.3 -0.5 -0.1 -0.2 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.7 2.1 3.0 0.9 -1.5 -1.7 -1.5
Whole body fat mass 3.5 14.7 20.1 -3.7 4.2 4.5 2.8
Leg fat mass (right) 3.7 14.3 18.8 -3.6 4.1 4.3 3.0
Arm predicted mass (right) 0.4 2.0 3.2 -1.1 1.8 1.7 0.6
Pulse rate, automated reading 4.2 13.5 20.3 -1.7 4.1 4.5 3.7
Alcohol intake frequency. 2.5 5.8 8.3 -2.9 2.6 2.3 1.8
Comparative height size at age 10 0.1 0.7 1.4 -0.5 1.2 0.9 0.7
Number of full sisters 1.8 2.1 4.7 2.2 -1.3 -1.1 -1.0
Suffer from ‘nerves’ 3.2 5.1 6.4 -1.9 2.2 2.3 2.5
Overall health rating 5.7 12.2 14.9 -3.0 3.5 3.9 3.5
Chest pain or discomfort 12.2 17.5 21.3 -3.5 4.6 4.5 4.1
Had major operations 1.8 2.1 2.5 -1.5 1.3 1.3 1.6
Age at last live birth 1.9 2.7 4.2 -2.1 1.9 1.6 0.4
Family relationship satisfaction 6.1 7.6 8.8 -2.2 3.0 3.0 2.8
Leg pain on walking 3.0 3.7 7.5 -1.2 1.8 1.6 2.7
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 1.1 1.0 -0.4 -0.2 0.1
Commuting to job workplace: Car/motor vehicle 0.8 0.9 2.2 -1.5 0.8 0.8 0.3
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 0.9 0.9 -0.5 -0.3 -0.8
Medication: Aspirin 0.1 0.2 0.3 -0.4 0.5 0.3 -0.4
Supplements: Vitamin C 0.2 0.2 0.5 -0.0 0.6 0.7 0.2
Knee pain experienced in last month 4.8 7.5 9.9 -2.1 2.9 2.7 3.1
Hypertension (Self-reported) 0.1 0.2 0.4 0.6 -0.3 -0.2 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 4.9 5.7 6.5 -2.4 2.5 2.4 2.3
Illnesses of father: Heart disease 0.2 0.2 0.3 -0.0 0.6 0.5 -0.5
Illnesses of siblings: Diabetes 1.5 1.8 2.7 -1.6 1.4 1.6 0.3
Smoking status: Previous 7.3 10.9 16.2 4.0 -3.6 -3.1 -2.2
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.0 0.0 0.2 -0.0 0.2 -0.2
Whole body fat-free mass 1.2 6.6 9.4 -2.3 3.1 3.0 1.7
Leg fat-free mass (right) 1.8 9.7 13.2 -3.0 3.6 3.6 2.0
Arm fat percentage (left) 6.5 25.7 33.1 -4.9 5.4 5.8 4.1
Average weekly red wine intake 0.8 1.2 1.8 1.3 -1.0 -1.0 -1.0
Handedness (chirality/laterality): Left-handed 2.2 2.7 3.8 -1.9 1.4 1.8 1.2
Mood swings 3.0 5.4 6.4 -2.0 2.3 2.5 2.5
Loneliness, isolation 1.3 1.8 3.2 -0.9 1.3 1.3 1.8
Long-standing illness, disability or infirmity 3.1 4.8 6.5 -1.6 2.4 2.5 2.1
Ever had bowel cancer screening 0.1 0.1 0.1 -0.1 -0.3 -0.3 0.3
Diabetes diagnosed by doctor 3.6 5.8 7.8 -2.4 2.8 2.6 1.8
Ever had stillbirth, spontaneous miscarriage or termination 5.7 6.0 7.4 2.7 -2.7 -2.7 -1.5
Friendships satisfaction 1.5 1.8 2.7 -1.3 1.5 1.6 0.9
Qualifications: nursing, teaching 4.9 7.7 12.1 -2.6 3.2 3.5 1.4
Commuting to job workplace: Walk 1.0 1.1 3.6 1.9 -0.7 -0.6 -0.3
Eye problems/disorders: Cataract 3.5 4.1 6.2 -1.8 1.9 1.9 2.5
Mouth/teeth dental problems: Mouth ulcers 1.7 2.7 4.3 2.1 -1.5 -1.7 -1.1
Medication for cholesterol 0.1 0.2 0.4 -0.7 0.3 0.3 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 1.2 -0.7 1.1 0.9 0.9
Back pain experienced in last month 3.4 5.0 7.5 -1.4 2.1 2.4 2.7
Mineral and other dietary supplements 0.2 0.3 0.5 -0.6 -0.4 -0.4 -0.7
Breast cancer (self-reported) 0.6 0.7 2.6 0.1 -0.5 -0.3 -1.6
Asthma (self-reported) 0.6 1.2 2.1 -0.7 1.2 1.4 0.9
Osteoporosis (self-reported) 0.3 0.3 0.6 0.8 -0.6 -0.6 -0.0
Osteoarthritis (self-reported) 2.2 2.9 3.5 -1.7 1.9 1.5 1.7
Medication: Aspirin 0.1 0.1 0.2 -0.3 0.4 0.1 -0.3
Medication: Gliclazide 1.6 1.8 3.9 -0.7 1.2 1.1 2.0
Illnesses of father: None of the above (group 1) 9.0 11.1 13.1 2.9 -3.6 -3.6 -3.2
Smoking status: Current 0.1 0.2 0.3 0.6 -0.5 -0.5 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 1.2 1.0 -1.1 -1.0 -0.5
Whole body water mass 1.2 7.0 9.8 -2.4 3.1 3.0 1.8
Leg predicted mass (right) 1.8 9.7 13.2 -2.9 3.6 3.6 2.0
Arm fat mass (left) 5.6 23.0 30.3 -4.6 5.2 5.5 3.7
Number of self-reported non-cancer illnesses 0.9 1.5 3.1 -1.0 1.1 0.8 1.8
Average weekly champagne plus white wine intake 0.4 0.5 1.1 -0.1 0.8 0.7 1.0
Miserableness 1.2 2.0 3.3 -0.6 1.4 1.5 1.8
Guilty feelings 2.7 4.0 5.7 -1.4 2.0 2.1 2.4
Wears glasses or contact lenses 1.1 1.3 1.9 0.9 -1.4 -1.2 -1.0
Ever taken oral contraceptive pill 0.2 0.2 0.4 0.5 -0.3 0.1 0.7
Hearing aid user 0.2 0.3 0.8 -0.9 -0.1 -0.0 -0.5
Mother’s age at death 0.1 0.1 0.3 0.4 -0.1 -0.3 0.5
Financial situation satisfaction 0.4 0.5 0.9 0.6 -0.8 -0.9 -0.0
Tinnitus: Yes, now most or all of the time 1.1 1.3 2.3 0.6 -1.5 -1.4 -0.8
Commuting to job workplace: Public transport 0.1 0.2 0.4 0.6 -0.4 -0.4 -0.0
Eye problems/disorders: Glaucoma 0.2 0.3 0.5 0.5 -0.4 -0.7 -0.4
Medication: Blood pressure 0.2 0.3 0.6 -0.4 0.5 0.8 0.6
Pain type(s) experienced in last month: Hip pain 1.2 1.5 2.9 -0.6 1.2 1.1 1.7
Supplements: Fish oil (including cod liver oil) 0.6 0.8 2.9 1.7 -0.4 -0.2 0.1
High cholesterol (Self-reported) 3.2 5.6 7.0 2.0 -2.4 -2.5 -2.6
Medication: Bendroflumethiazide 0.0 0.1 0.1 0.4 -0.3 -0.0 -0.1
Medication: Paracetamol 0.2 0.3 1.0 0.2 0.1 0.3 1.0
Medication: Lisinopril 0.8 1.1 2.3 1.5 -1.0 -0.7 -0.7
Medication: Atorvastatin 0.1 0.1 0.2 -0.3 0.1 0.2 -0.4
Illnesses of father: High blood pressure 4.7 5.8 6.4 -2.0 2.5 2.5 2.5
Alcohol drinker status: Never 0.3 0.3 0.7 -0.8 0.5 0.5 0.3
Ever smoked 7.1 12.5 19.3 4.4 -3.7 -3.4 -2.2
Basal metabolic rate 1.8 10.1 13.5 -2.9 3.7 3.7 2.2
Leg fat percentage (left) 2.7 9.6 12.6 -2.9 3.3 3.5 2.6
Arm fat-free mass (left) 1.3 6.4 8.8 -2.2 3.0 2.9 1.9
Number of operations (self-reported) 3.5 5.2 6.8 -2.3 2.4 2.6 1.7
Average weekly beer plus cider intake 4.0 5.8 8.7 2.9 -2.5 -2.4 -1.5
Irritability 0.1 0.1 0.2 0.0 0.3 0.4 -0.4
Risk taking 0.3 0.4 0.8 0.6 -0.6 -0.9 -0.5
Ever had prostate specific antigen (PSA) test 0.4 0.4 1.1 -1.0 0.4 0.6 -0.3
Fractured/broken bones in last 5 years 0.3 0.4 1.1 0.4 -0.0 -0.3 1.1
Age started oral contraceptive pill 3.6 4.5 6.5 -2.5 2.0 2.0 1.9
Diastolic blood pressure, automated reading 0.3 1.1 1.5 1.2 -1.2 -0.8 -0.8
Ever depressed for a whole week 0.3 0.3 0.6 0.8 -0.7 -0.4 -0.1
Unable to work because of sickness or disability 0.6 0.7 1.5 0.0 0.9 1.2 0.8
Commuting to job workplace: Cycle 0.8 0.9 3.4 1.8 -0.4 -0.3 -0.3
Myopia 0.2 0.3 0.6 -0.2 -0.6 -0.4 -0.8
Vascular/heart problems diagnosed by doctor 0.0 0.0 0.1 -0.0 -0.1 -0.0 -0.4
Cholesterol lowering medication 0.0 0.0 0.1 -0.3 0.2 0.0 -0.3
Medication: Omeprazole (e.g. Zanprol) 4.5 5.5 6.5 -2.1 2.5 2.2 2.5
Pain experienced in last month 7.6 12.7 21.4 2.2 -3.5 -3.6 -4.6
Supplements: Calcium 1.2 1.3 2.4 -1.0 1.0 0.9 1.5
Basal cell carcinoma (self-reported) 1.6 1.9 3.3 1.8 -1.2 -1.3 -1.0
Heart attack/myocardial infarction (self-reported) 0.4 0.5 0.8 0.8 -0.4 -0.6 -0.9
Deep venous thrombosis (DVT) (self-reported) 0.3 0.3 0.9 1.0 -0.5 -0.5 -0.2
Heart disease (siblings) 0.7 0.8 2.6 1.6 -0.6 -0.5 -0.3
Alcohol drinker status: Previous 0.6 0.7 0.9 -0.7 0.9 0.7 1.0
Pack years of smoking 0.3 0.5 1.0 1.0 -0.3 -0.5 -0.7
Impedance of whole body 1.8 9.2 11.7 3.2 -3.4 -3.1 -2.3
Leg fat mass (left) 3.3 13.1 17.3 -3.5 3.9 4.2 2.8
Arm predicted mass (left) 1.4 6.9 9.3 -2.4 3.0 3.0 2.0