Hub : Genes

TMOD3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.171	0.067	6.1e-05	0.025	NA	0.053	NA	0.043	1.5e-02	NA	7.1e-04	NA	2.1e-03
2	GTEx	Skin Not Sun Exposed Suprapubic	0.054	0.023	1.6e-03	0.065	NA	0.075	NA	0.066	1.8e-04	NA	6.4e-05	NA	1.7e-04
3	GTEx	Skin Sun Exposed Lower leg	0.070	0.027	4.2e-05	0.067	NA	0.063	NA	0.060	3.1e-06	NA	6.0e-06	NA	9.8e-06
4	GTEx	Testis	0.141	0.051	5.9e-05	0.108	NA	0.159	NA	0.141	1.6e-05	NA	1.5e-07	NA	8.1e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.6	0.9	1.6	0.2	-1.1	-1.0	-1.2
Bipolar Disorder or Schizophrenia	0.7	1.6	5.0	-0.4	-1.0	-0.6	-2.2
Depressed Affect (Nagel 2018)	1.2	2.5	3.5	-0.9	1.6	1.9	1.8
Depression (Nagel 2018)	1.8	2.7	4.5	-1.2	1.6	1.5	2.1
Intelligence (Savage-Jansen 2018)	1.9	5.7	7.6	-2.8	2.5	2.7	1.3
Neuroticism (Nagel 2018)	1.2	2.8	4.3	-1.0	1.7	2.1	1.7
Schizophrenia (2018)	0.5	1.0	3.5	-0.6	-0.3	-0.0	-1.9
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	-0.1	-0.0	0.1	-0.0
Worry (Nagel 2018)	0.9	1.8	2.4	-1.0	1.2	1.6	1.5
Alzheimer’s Disease (in mother)	0.0	0.1	0.2	-0.1	0.2	0.4	-0.0
Alzheimer’s Disease (in father)	1.3	1.4	2.2	-0.4	1.4	1.5	1.1
Alzheimer’s Disease (including proxy)	0.7	1.0	1.7	-0.6	1.2	1.3	0.7
Crohns Disease (2017)	0.1	0.3	0.5	-0.7	0.3	0.7	0.0
Irritable Bowel Disease (IBD)	0.3	0.7	2.3	-1.5	0.3	0.7	0.1
Ulcerative Colitis (UC)	0.4	0.8	2.6	-1.6	0.3	0.5	0.4
Major Depression (MDD)	3.3	4.0	5.8	-1.5	2.3	2.4	1.7
Reaction Time	1.1	2.0	3.1	-1.0	1.5	1.3	1.8
Verbal and Numeric Reasoning (VNR)	1.5	3.5	4.3	-2.1	1.9	2.0	1.5
Breast Cancer	0.1	0.3	0.8	-0.0	0.5	0.9	-0.1
Ovarian Cancer	0.3	0.4	0.5	-0.7	0.6	0.7	0.7
Prostate Cancer	2.1	2.9	5.9	-1.7	1.5	1.0	2.4
Age at First Birth	0.0	0.0	0.1	-0.0	0.1	-0.0	0.3
Bipolar Disorder (2011)	0.3	0.3	0.6	0.3	-0.7	-0.8	-0.1
Body Mass Index (BMI) (2010)	4.6	6.3	7.1	-2.7	2.5	2.4	2.4
Coronary Artery Disease (CAD)	0.2	0.3	0.6	-0.8	0.5	0.4	0.3
Crohns Disease (2012)	0.3	0.5	0.6	-0.8	0.7	0.7	0.6
Mean Putamen Volume	4.2	4.8	6.0	-2.0	2.2	2.1	2.4
Fasting Glucose	0.1	0.1	0.1	0.2	0.2	0.3	-0.3
HbA1C	0.6	0.6	2.0	0.4	-0.6	-0.2	-1.4
HDL Cholesterol	3.6	6.0	8.1	-2.2	2.3	2.4	2.8
LDL Cholesterol	0.3	0.5	0.8	-0.6	0.5	0.7	0.9
Lupus	0.4	0.6	1.2	-0.9	0.7	1.1	0.3
Neuroticism (2016)	0.2	0.3	0.8	0.5	0.3	0.5	0.9
Primary Biliary Cirrhosis	0.4	0.6	2.0	0.4	-0.2	-0.2	1.4
Rheumatoid Arthritis	0.9	1.2	2.8	-1.1	0.6	0.7	1.7
Schizophrenia (2014)	0.3	0.7	2.6	-0.5	-0.4	-0.1	-1.6
Triglycerides	0.5	0.9	1.3	1.1	-1.1	-0.9	-0.3
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	0.4	-0.3	-0.2	-0.2
Ulcerative Colitis	0.3	0.4	0.7	-0.2	-0.8	-0.6	-0.8
Blood Eosinophil Count	0.5	4.0	4.7	-1.8	2.1	2.2	2.0
Blood Platelet Count	0.6	6.6	10.6	-2.0	3.3	2.9	1.7
Blood Red Count	0.0	0.4	0.6	0.4	0.6	0.7	0.8
Blood White Count	0.2	1.6	3.5	-0.6	1.2	1.9	1.0
Heel T-Score	0.4	2.9	6.3	-2.5	1.9	1.3	0.0
BMI	6.0	34.9	41.9	-5.8	6.3	6.5	5.0
Height	0.1	1.4	2.0	1.3	-1.1	-0.9	-1.4
Waist Hip Ratio (WHR)	0.3	1.5	2.9	0.7	1.2	1.7	1.1
Systolic Blood Pressure	0.5	2.3	3.9	1.7	-2.0	-1.4	-0.7
Smoking Status	3.4	8.2	11.7	3.4	-3.1	-2.7	-1.9
Allergy or Eczema	0.2	0.6	1.0	-0.5	0.9	1.0	0.4
Cardiovascular Disease	0.0	0.1	0.2	0.5	-0.1	0.2	0.2
Hypothyroidism (self reported)	0.0	0.1	0.1	-0.3	0.2	0.3	-0.1
Respiratory disease	0.9	2.0	2.8	-1.1	1.4	1.4	1.7
Type 2 Diabetes (T2D) (2018)	3.0	5.7	7.0	-2.2	2.6	2.6	2.0
Lung FEV1/FVC ratio	0.4	2.1	3.0	1.7	-1.5	-1.3	-1.1
Lung FVC	1.0	5.2	6.6	2.6	-2.3	-2.3	-1.9
Neuroticism	0.8	1.9	3.5	-0.9	1.4	1.9	1.1
Chronotype (morning person)	1.0	2.3	3.4	1.5	-1.9	-1.8	-0.2
Hair Pigment	0.0	0.5	0.6	0.7	-0.8	-0.7	0.6
Tanning	0.2	2.0	2.9	1.4	-1.7	-1.5	-1.0
Hand grip strength (left)	1.4	3.8	4.7	1.5	-2.2	-2.0	-2.0
Number of treatments/medications taken	0.3	0.5	1.4	0.0	0.5	0.4	1.2
Average weekly spirits intake	1.1	1.3	2.1	0.4	-1.3	-1.4	-1.2
Sensitivity / hurt feelings	0.0	0.0	0.0	0.1	-0.2	0.1	0.0
Frequency of depressed mood in last 2 weeks	1.0	1.4	1.8	-0.9	1.2	1.2	1.3
Hearing difficulty/problems: Yes	8.9	13.5	15.8	-4.0	3.7	3.7	3.3
Relative age of first facial hair	0.6	1.2	1.3	1.1	-1.1	-1.1	-1.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.4	-0.7	1.0	1.2	0.1
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.4	0.6	-0.5	-0.6	0.5
Ever had hysterectomy (womb removed)	3.6	4.0	5.3	-2.1	1.7	1.9	2.3
Systolic blood pressure, automated reading	0.3	0.8	1.7	0.8	-1.3	-0.8	-0.7
Eye problems/disorders: Diabetes related eye disease	1.9	2.1	3.5	-0.8	1.6	1.3	1.9
Angina	2.6	3.5	4.5	-2.1	2.1	1.9	1.2
Medication for hormone replacement therapy	0.7	0.8	0.9	1.0	-0.9	-1.0	-0.6
Vitamin and mineral supplements	0.2	0.2	0.7	0.1	-0.3	-0.1	-0.9
Supplements: Zinc	0.1	0.1	0.4	-0.0	0.4	0.6	-0.0
Medication: Co-codamol	2.5	2.9	3.8	-1.6	1.9	1.8	1.4
Medication: Metformin	3.2	4.6	6.8	-2.1	2.6	2.2	1.6
Diabetes (father)	0.1	0.1	0.1	0.4	-0.3	-0.2	0.2
Diabetes (mother)	2.5	3.2	4.1	-1.8	1.6	1.7	2.0
Severe depression (siblings)	0.1	0.1	0.4	-0.7	0.0	0.1	-0.2
Pack years adult smoking proportion	0.4	0.6	1.5	1.2	-0.3	-0.5	-0.7
Impedance of leg (right)	2.1	10.4	13.6	3.5	-3.7	-3.5	-1.9
Leg fat-free mass (left)	2.2	11.7	15.3	-3.2	3.9	3.9	2.4
Trunk fat percentage	2.6	10.5	15.1	-3.1	3.5	3.9	2.2
Hand grip strength (right)	0.5	1.3	1.8	0.8	-1.3	-1.2	-1.2
Townsend deprivation index at recruitment	0.4	0.5	1.4	0.3	0.5	0.6	1.2
Current tobacco smoking	0.1	0.2	0.3	0.5	-0.4	-0.5	0.2
Average weekly fortified wine intake	0.9	1.0	3.4	0.0	-0.5	-0.6	-1.9
Maternal smoking around birth	0.5	0.7	2.4	1.6	-0.3	-0.2	0.4
Fed-up feelings	0.8	1.4	2.6	0.0	1.0	1.3	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	3.9	5.2	8.1	-1.8	2.2	2.2	2.9
Relative age voice broke	0.6	0.9	1.5	0.6	-0.8	-1.0	-1.2
Taking other prescription medications	3.5	5.4	6.1	-2.5	2.3	2.5	2.0
Age when periods started (menarche)	0.1	0.3	1.1	0.5	0.1	-0.2	1.0
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.2	-0.1	0.1	0.2	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	1.7	-1.3	1.3	1.1	0.6
Tinnitus: Yes, but not now, but have in the past	1.9	2.1	2.5	-1.5	1.3	1.3	1.6
Qualifications: CSEs or equivalent	1.2	1.7	2.2	-1.0	1.5	1.5	1.1
Serious illness, injury or assault to yourself	0.2	0.3	0.5	0.5	-0.5	-0.7	-0.2
High blood pressure	0.0	0.0	0.1	0.3	-0.0	0.0	0.2
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.4	-0.7	0.6	0.5	0.0
Multivitamins +/- minerals	0.0	0.0	0.1	0.1	-0.0	-0.1	0.2
Stomach or abdominal pain in last month	4.6	5.7	8.4	-2.1	2.3	2.1	2.9
Supplements: Glucosamine	0.2	0.3	0.5	-0.2	0.7	0.7	0.6
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	2.2	-1.3	1.5	1.5	1.2
Medication: Atenolol	0.7	0.9	2.4	-0.3	-0.7	-0.7	-1.5
Medication: Levothyroxine sodium	1.1	1.9	2.2	1.4	-1.4	-1.5	-1.2
Sitting height	1.9	13.7	15.8	3.2	-3.7	-3.9	-4.0
Chronic bronchitis/emphysema (father)	0.1	0.1	0.5	0.7	-0.1	-0.2	0.2
High blood pressure (mother)	1.6	2.2	4.1	-2.0	1.6	1.3	0.6
Body mass index (BMI)	5.3	22.7	28.5	-4.7	5.1	5.3	3.8
Impedance of leg (left)	3.2	15.5	19.0	4.1	-4.4	-4.2	-3.0
Leg predicted mass (left)	2.3	12.0	15.7	-3.3	4.0	4.0	2.4
Trunk fat mass	2.8	11.8	16.8	-3.3	3.8	4.1	2.4
Waist circumference	5.7	20.9	28.4	-4.1	5.0	5.3	3.6
Number of incorrect matches in round	0.2	0.3	0.5	0.7	-0.4	-0.5	-0.5
Past tobacco smoking	8.2	15.1	22.8	-4.8	4.1	3.7	2.6
Alcohol usually taken with meals	0.1	0.1	0.4	-0.2	-0.4	-0.6	0.1
Nervous feelings	0.3	0.6	1.3	-0.5	0.5	0.8	1.1
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	3.5	-1.1	1.5	1.4	1.9
Hearing difficulty/problems with background noise	5.4	8.6	12.2	-3.5	3.1	2.9	2.1
Hair/balding pattern: Pattern 2	0.4	0.6	0.9	-1.0	0.6	0.7	0.7
Had menopause	0.2	0.3	0.6	-0.8	0.3	0.2	0.7
Had other major operations	0.6	0.8	1.5	-0.7	1.1	1.2	0.1
Forced vital capacity (FVC)	0.6	2.4	4.8	2.2	-1.3	-1.0	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	2.4	-1.5	1.6	1.3	1.0
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.9	-0.4	-0.0	0.3	0.9
Qualifications: None of the above	1.3	2.8	3.6	1.7	-1.6	-1.9	-1.4
Financial difficulties in last 2 years	1.3	1.7	2.5	-1.6	1.4	1.4	0.8
Mouth/teeth dental problems	0.0	0.0	0.0	0.1	-0.0	0.0	0.1
Heart attack	0.6	0.8	1.0	0.9	-0.7	-0.9	-1.0
Allergy	0.1	0.3	0.4	0.1	-0.7	-0.7	-0.5
Pain all over the body in last month	0.1	0.1	0.5	0.1	-0.1	0.0	0.7
Diabetes (self-reported)	2.5	3.8	5.1	-1.7	2.3	2.1	1.7
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.1	-0.3	0.4	0.4	-0.4
Medication: Ramipril	0.0	0.0	0.0	0.2	0.1	-0.0	0.0
Medication: Simvastatin	2.4	3.6	5.1	1.8	-1.8	-2.3	-1.6
Fluid intelligence score	0.6	1.2	1.9	-1.2	1.1	1.4	0.3
Illnesses of siblings	0.3	0.5	0.7	0.8	-0.8	-0.7	-0.2
Neuroticism score	2.0	4.1	5.9	-1.5	2.1	2.4	2.1
Weight	3.3	16.1	21.6	-3.8	4.5	4.7	3.0
Impedance of arm (right)	0.1	0.3	0.6	0.7	-0.7	-0.4	-0.3
Arm fat percentage (right)	7.9	31.3	39.2	-5.4	5.9	6.3	4.7
Trunk fat-free mass	0.8	4.9	7.2	-1.9	2.7	2.6	1.5
Hip circumference	3.6	15.6	19.6	-4.2	4.3	4.4	2.6
Time employed in main current job	2.5	2.9	4.0	1.6	-2.0	-1.8	-1.3
Alcohol intake versus 10 years previously	0.1	0.1	0.2	-0.5	-0.1	-0.1	-0.3
Father’s age at death	0.3	0.5	1.0	-0.8	0.5	0.1	1.0
Worrier / anxious feelings	1.7	3.3	4.7	-1.7	1.8	2.2	1.5
Frequency of tiredness / lethargy in last 2 weeks	12.3	20.0	22.8	-4.6	4.8	4.4	4.1
Falls in the last year	0.2	0.3	0.9	-0.1	0.4	0.2	1.0
Hair/balding pattern: Pattern 3	0.1	0.1	0.1	-0.2	0.4	0.4	0.3
Number of live births	0.0	0.1	0.2	0.4	0.1	-0.1	-0.0
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	3.0	1.7	-0.9	-0.7	-1.2
Pulse rate	2.1	3.6	5.1	-1.5	1.8	2.0	2.3
Happiness	1.2	1.4	2.6	-0.7	1.2	1.6	1.1
Noisy workplace	7.3	9.0	10.3	-2.8	3.2	3.1	2.9
Qualifications: A levels/AS levels or equivalent	0.5	1.1	3.5	0.1	-0.6	-0.7	-1.9
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.6	0.2	-0.8	-0.6	-0.3
Mouth/teeth dental problems: Dentures	0.0	0.0	0.0	0.0	0.0	-0.0	-0.0
Asthma	0.6	1.2	1.9	-0.8	1.2	1.4	0.8
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	2.1	1.4	-1.2	-1.1	-1.5
Medication: Cholesterol lowering	1.5	2.3	2.8	1.4	-1.6	-1.7	-1.3
Depression (self-reported)	2.7	3.2	4.2	-1.6	1.8	1.7	2.0
Medication: Lansoprazole	0.9	1.0	2.6	-0.6	0.8	0.7	1.6
Prospective memory result	0.8	1.0	1.8	1.0	-1.0	-1.4	0.2
Lung cancer (father)	0.2	0.2	0.5	0.4	0.4	0.1	0.7
Illnesses of mother	0.6	0.8	1.9	1.4	-0.8	-0.7	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.6	1.6	-0.9	-0.7	-0.8
Pulse wave Arterial Stiffness index	1.2	1.3	2.0	1.4	-1.1	-0.8	-1.2
Impedance of arm (left)	0.4	1.9	2.5	1.5	-1.6	-1.2	-1.1
Arm fat mass (right)	6.1	25.0	31.8	-4.9	5.4	5.6	4.0
Trunk predicted mass	0.8	4.4	6.5	-1.8	2.6	2.5	1.4
Standing height	0.2	1.7	2.6	1.6	-1.0	-1.0	-1.5
Length of working week for main job	0.5	0.6	0.8	0.9	-0.9	-0.7	-0.4
Exposure to tobacco smoke at home	0.5	0.6	1.1	-1.1	0.7	0.7	0.1
Breastfed as a baby	0.2	0.3	0.6	-0.8	0.5	0.5	-0.1
Tense / ‘highly strung’	1.1	1.8	2.0	-1.2	1.4	1.3	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	3.7	5.6	8.8	-1.6	2.1	2.5	3.0
Hair/balding pattern: Pattern 4	2.8	6.9	7.1	-2.5	2.7	2.6	2.7
Birth weight of first child	2.1	3.9	8.1	-1.1	2.3	2.9	1.0
Peak expiratory flow (PEF)	1.0	2.3	3.9	1.4	-1.3	-1.2	-2.0
Pulse wave reflection index	1.2	1.5	3.4	1.0	-1.1	-0.7	-1.8
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	-0.6	0.5	0.2	0.5
Loud music exposure frequency	5.9	6.4	8.7	-3.0	2.6	2.5	2.0
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	3.6	-1.9	1.0	1.0	0.5
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	-0.5	0.1	0.1	-0.2
Blood clot in the leg (DVT)	0.2	0.3	0.7	0.8	-0.4	-0.4	-0.2
Medication: Paracetamol	0.2	0.4	1.1	0.6	-0.3	-0.0	1.1
Headache pain in last month	1.2	2.1	4.4	-1.0	1.2	1.2	2.1
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	1.9	-1.0	1.3	1.4	0.9
Glaucoma (self-reported)	0.1	0.1	0.1	0.3	-0.2	-0.3	-0.2
Gout (self-reported)	0.3	0.4	0.6	-0.5	-0.6	-0.8	-0.7
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.2	0.0	0.0	0.0	-0.4
Medication: Amlodipine	2.2	3.1	5.2	-1.5	1.6	1.5	2.3
Medication: Ventolin 100micrograms inhaler	1.6	2.0	2.9	-1.0	1.6	1.7	1.4
Birth weight	1.4	2.9	4.6	-1.6	2.1	2.2	0.4
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.2	-0.2	-0.3	-0.5
High blood pressure (siblings)	0.2	0.3	0.9	0.2	-0.3	-0.4	-0.9
Forced vital capacity (FVC), Best measure	0.5	1.8	3.9	2.0	-1.2	-0.8	-1.2
Body fat percentage	3.5	13.8	18.7	-3.6	4.0	4.3	2.8
Leg fat percentage (right)	3.2	11.6	14.6	-3.1	3.5	3.8	3.1
Arm fat-free mass (right)	0.4	1.9	3.1	-1.1	1.8	1.7	0.6
Exposure to tobacco smoke outside home	0.7	0.9	2.6	-0.7	0.6	0.5	1.6
Comparative body size at age 10	1.1	3.0	5.9	-2.4	1.8	1.7	-0.2
Number of full brothers	0.2	0.3	0.5	0.4	0.7	0.6	0.2
Worry too long after embarrassment	0.2	0.4	0.7	-0.9	0.7	0.7	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.8	-0.7	1.0	1.2	1.7
Wheeze or whistling in the chest in last year	3.9	7.0	9.7	-1.8	3.1	3.1	2.3
Number of children fathered	0.0	0.1	0.1	-0.0	-0.2	-0.2	0.4
Reason for reducing amount of alcohol drunk: Health precaution	2.4	2.8	3.6	1.9	-1.6	-1.6	-1.5
Age at first live birth	0.5	0.8	2.8	0.1	-0.5	-0.6	-1.7
Pulse wave peak to peak time	1.0	1.2	1.7	-1.3	1.1	0.7	1.2
Health satisfaction	0.9	1.2	1.9	-1.2	1.0	1.4	0.7
Shortness of breath walking on level ground	4.0	4.8	5.8	-2.4	2.3	2.4	1.5
Qualifications: College or University degree	0.6	1.8	2.7	-1.6	1.6	1.4	0.1
Eye problems/disorders: None of the above	4.8	5.5	8.2	1.8	-2.5	-2.2	-2.9
Mouth/teeth dental problems: Loose teeth	0.7	0.9	1.2	-0.8	1.0	1.1	0.8
Emphysema/chronic bronchitis	0.4	0.5	1.8	0.1	0.4	0.2	1.3
Medication for pain relief, constipation, heartburn	0.5	0.8	2.0	0.5	-0.9	-0.6	-1.4
Neck or shoulder pain in last month	7.2	10.2	12.0	-2.6	3.4	3.2	3.5
Medication: Blood pressure	0.1	0.3	0.6	0.4	-0.6	-0.7	-0.0
Angina (self-reported)	2.5	3.3	4.4	-1.9	2.1	1.8	1.3
Migraine (self-reported)	0.8	0.9	1.5	0.5	-1.2	-1.2	-0.8
Medication: Ibuprofen	0.4	0.5	0.9	1.0	-0.6	-0.5	-0.8
Medication: Allopurinol	0.9	1.1	1.5	0.4	-1.2	-1.2	-1.2
Medication: Omeprazole	2.8	3.3	4.1	-1.7	2.0	1.7	1.9
Medication: Seretide 50 evohaler	0.1	0.1	0.1	-0.0	0.3	0.2	0.3
Mean time to correctly identify matches	1.9	3.6	5.6	-1.6	1.9	1.6	2.4
Heart disease (mother)	0.1	0.1	0.3	-0.5	-0.1	-0.2	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.1	3.0	0.9	-1.5	-1.7	-1.5
Whole body fat mass	3.5	14.7	20.1	-3.7	4.2	4.5	2.8
Leg fat mass (right)	3.7	14.3	18.8	-3.6	4.1	4.3	3.0
Arm predicted mass (right)	0.4	2.0	3.2	-1.1	1.8	1.7	0.6
Pulse rate, automated reading	4.2	13.5	20.3	-1.7	4.1	4.5	3.7
Alcohol intake frequency.	2.5	5.8	8.3	-2.9	2.6	2.3	1.8
Comparative height size at age 10	0.1	0.7	1.4	-0.5	1.2	0.9	0.7
Number of full sisters	1.8	2.1	4.7	2.2	-1.3	-1.1	-1.0
Suffer from ‘nerves’	3.2	5.1	6.4	-1.9	2.2	2.3	2.5
Overall health rating	5.7	12.2	14.9	-3.0	3.5	3.9	3.5
Chest pain or discomfort	12.2	17.5	21.3	-3.5	4.6	4.5	4.1
Had major operations	1.8	2.1	2.5	-1.5	1.3	1.3	1.6
Age at last live birth	1.9	2.7	4.2	-2.1	1.9	1.6	0.4
Family relationship satisfaction	6.1	7.6	8.8	-2.2	3.0	3.0	2.8
Leg pain on walking	3.0	3.7	7.5	-1.2	1.8	1.6	2.7
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.1	1.0	-0.4	-0.2	0.1
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.2	-1.5	0.8	0.8	0.3
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.9	0.9	-0.5	-0.3	-0.8
Medication: Aspirin	0.1	0.2	0.3	-0.4	0.5	0.3	-0.4
Supplements: Vitamin C	0.2	0.2	0.5	-0.0	0.6	0.7	0.2
Knee pain experienced in last month	4.8	7.5	9.9	-2.1	2.9	2.7	3.1
Hypertension (Self-reported)	0.1	0.2	0.4	0.6	-0.3	-0.2	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.9	5.7	6.5	-2.4	2.5	2.4	2.3
Illnesses of father: Heart disease	0.2	0.2	0.3	-0.0	0.6	0.5	-0.5
Illnesses of siblings: Diabetes	1.5	1.8	2.7	-1.6	1.4	1.6	0.3
Smoking status: Previous	7.3	10.9	16.2	4.0	-3.6	-3.1	-2.2
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.0	0.0	0.2	-0.0	0.2	-0.2
Whole body fat-free mass	1.2	6.6	9.4	-2.3	3.1	3.0	1.7
Leg fat-free mass (right)	1.8	9.7	13.2	-3.0	3.6	3.6	2.0
Arm fat percentage (left)	6.5	25.7	33.1	-4.9	5.4	5.8	4.1
Average weekly red wine intake	0.8	1.2	1.8	1.3	-1.0	-1.0	-1.0
Handedness (chirality/laterality): Left-handed	2.2	2.7	3.8	-1.9	1.4	1.8	1.2
Mood swings	3.0	5.4	6.4	-2.0	2.3	2.5	2.5
Loneliness, isolation	1.3	1.8	3.2	-0.9	1.3	1.3	1.8
Long-standing illness, disability or infirmity	3.1	4.8	6.5	-1.6	2.4	2.5	2.1
Ever had bowel cancer screening	0.1	0.1	0.1	-0.1	-0.3	-0.3	0.3
Diabetes diagnosed by doctor	3.6	5.8	7.8	-2.4	2.8	2.6	1.8
Ever had stillbirth, spontaneous miscarriage or termination	5.7	6.0	7.4	2.7	-2.7	-2.7	-1.5
Friendships satisfaction	1.5	1.8	2.7	-1.3	1.5	1.6	0.9
Qualifications: nursing, teaching	4.9	7.7	12.1	-2.6	3.2	3.5	1.4
Commuting to job workplace: Walk	1.0	1.1	3.6	1.9	-0.7	-0.6	-0.3
Eye problems/disorders: Cataract	3.5	4.1	6.2	-1.8	1.9	1.9	2.5
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	4.3	2.1	-1.5	-1.7	-1.1
Medication for cholesterol	0.1	0.2	0.4	-0.7	0.3	0.3	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.2	-0.7	1.1	0.9	0.9
Back pain experienced in last month	3.4	5.0	7.5	-1.4	2.1	2.4	2.7
Mineral and other dietary supplements	0.2	0.3	0.5	-0.6	-0.4	-0.4	-0.7
Breast cancer (self-reported)	0.6	0.7	2.6	0.1	-0.5	-0.3	-1.6
Asthma (self-reported)	0.6	1.2	2.1	-0.7	1.2	1.4	0.9
Osteoporosis (self-reported)	0.3	0.3	0.6	0.8	-0.6	-0.6	-0.0
Osteoarthritis (self-reported)	2.2	2.9	3.5	-1.7	1.9	1.5	1.7
Medication: Aspirin	0.1	0.1	0.2	-0.3	0.4	0.1	-0.3
Medication: Gliclazide	1.6	1.8	3.9	-0.7	1.2	1.1	2.0
Illnesses of father: None of the above (group 1)	9.0	11.1	13.1	2.9	-3.6	-3.6	-3.2
Smoking status: Current	0.1	0.2	0.3	0.6	-0.5	-0.5	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.2	1.0	-1.1	-1.0	-0.5
Whole body water mass	1.2	7.0	9.8	-2.4	3.1	3.0	1.8
Leg predicted mass (right)	1.8	9.7	13.2	-2.9	3.6	3.6	2.0
Arm fat mass (left)	5.6	23.0	30.3	-4.6	5.2	5.5	3.7
Number of self-reported non-cancer illnesses	0.9	1.5	3.1	-1.0	1.1	0.8	1.8
Average weekly champagne plus white wine intake	0.4	0.5	1.1	-0.1	0.8	0.7	1.0
Miserableness	1.2	2.0	3.3	-0.6	1.4	1.5	1.8
Guilty feelings	2.7	4.0	5.7	-1.4	2.0	2.1	2.4
Wears glasses or contact lenses	1.1	1.3	1.9	0.9	-1.4	-1.2	-1.0
Ever taken oral contraceptive pill	0.2	0.2	0.4	0.5	-0.3	0.1	0.7
Hearing aid user	0.2	0.3	0.8	-0.9	-0.1	-0.0	-0.5
Mother’s age at death	0.1	0.1	0.3	0.4	-0.1	-0.3	0.5
Financial situation satisfaction	0.4	0.5	0.9	0.6	-0.8	-0.9	-0.0
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.3	0.6	-1.5	-1.4	-0.8
Commuting to job workplace: Public transport	0.1	0.2	0.4	0.6	-0.4	-0.4	-0.0
Eye problems/disorders: Glaucoma	0.2	0.3	0.5	0.5	-0.4	-0.7	-0.4
Medication: Blood pressure	0.2	0.3	0.6	-0.4	0.5	0.8	0.6
Pain type(s) experienced in last month: Hip pain	1.2	1.5	2.9	-0.6	1.2	1.1	1.7
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.9	1.7	-0.4	-0.2	0.1
High cholesterol (Self-reported)	3.2	5.6	7.0	2.0	-2.4	-2.5	-2.6
Medication: Bendroflumethiazide	0.0	0.1	0.1	0.4	-0.3	-0.0	-0.1
Medication: Paracetamol	0.2	0.3	1.0	0.2	0.1	0.3	1.0
Medication: Lisinopril	0.8	1.1	2.3	1.5	-1.0	-0.7	-0.7
Medication: Atorvastatin	0.1	0.1	0.2	-0.3	0.1	0.2	-0.4
Illnesses of father: High blood pressure	4.7	5.8	6.4	-2.0	2.5	2.5	2.5
Alcohol drinker status: Never	0.3	0.3	0.7	-0.8	0.5	0.5	0.3
Ever smoked	7.1	12.5	19.3	4.4	-3.7	-3.4	-2.2
Basal metabolic rate	1.8	10.1	13.5	-2.9	3.7	3.7	2.2
Leg fat percentage (left)	2.7	9.6	12.6	-2.9	3.3	3.5	2.6
Arm fat-free mass (left)	1.3	6.4	8.8	-2.2	3.0	2.9	1.9
Number of operations (self-reported)	3.5	5.2	6.8	-2.3	2.4	2.6	1.7
Average weekly beer plus cider intake	4.0	5.8	8.7	2.9	-2.5	-2.4	-1.5
Irritability	0.1	0.1	0.2	0.0	0.3	0.4	-0.4
Risk taking	0.3	0.4	0.8	0.6	-0.6	-0.9	-0.5
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.1	-1.0	0.4	0.6	-0.3
Fractured/broken bones in last 5 years	0.3	0.4	1.1	0.4	-0.0	-0.3	1.1
Age started oral contraceptive pill	3.6	4.5	6.5	-2.5	2.0	2.0	1.9
Diastolic blood pressure, automated reading	0.3	1.1	1.5	1.2	-1.2	-0.8	-0.8
Ever depressed for a whole week	0.3	0.3	0.6	0.8	-0.7	-0.4	-0.1
Unable to work because of sickness or disability	0.6	0.7	1.5	0.0	0.9	1.2	0.8
Commuting to job workplace: Cycle	0.8	0.9	3.4	1.8	-0.4	-0.3	-0.3
Myopia	0.2	0.3	0.6	-0.2	-0.6	-0.4	-0.8
Vascular/heart problems diagnosed by doctor	0.0	0.0	0.1	-0.0	-0.1	-0.0	-0.4
Cholesterol lowering medication	0.0	0.0	0.1	-0.3	0.2	0.0	-0.3
Medication: Omeprazole (e.g. Zanprol)	4.5	5.5	6.5	-2.1	2.5	2.2	2.5
Pain experienced in last month	7.6	12.7	21.4	2.2	-3.5	-3.6	-4.6
Supplements: Calcium	1.2	1.3	2.4	-1.0	1.0	0.9	1.5
Basal cell carcinoma (self-reported)	1.6	1.9	3.3	1.8	-1.2	-1.3	-1.0
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.8	0.8	-0.4	-0.6	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.9	1.0	-0.5	-0.5	-0.2
Heart disease (siblings)	0.7	0.8	2.6	1.6	-0.6	-0.5	-0.3
Alcohol drinker status: Previous	0.6	0.7	0.9	-0.7	0.9	0.7	1.0
Pack years of smoking	0.3	0.5	1.0	1.0	-0.3	-0.5	-0.7
Impedance of whole body	1.8	9.2	11.7	3.2	-3.4	-3.1	-2.3
Leg fat mass (left)	3.3	13.1	17.3	-3.5	3.9	4.2	2.8
Arm predicted mass (left)	1.4	6.9	9.3	-2.4	3.0	3.0	2.0