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chr19:17,512,412-19,237,273

Best TWAS P=1.64e-18 · Best GWAS P=8.37e-19 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	MAST3	0.02	0.02	lasso	3	0.01	1.5e-02	8.6	-8.8	1.6e-18	-0.95	0.01	0.96	TRUE
14	YFS	Blood	MAST3	0.06	0.04	lasso	5	0.04	4.2e-12	7.8	-7.3	2.0e-13	-0.56	0.83	0.17	TRUE
12	ROSMAP	Brain Pre-frontal Cortex	JUND	0.17	0.17	lasso	5	0.20	2.7e-25	7.7	6.4	1.3e-10	0.13	0.93	0.07	TRUE
2	GTEx	Colon Transverse	SSBP4	0.18	0.01	enet	21	0.00	3.6e-01	4.6	-6.2	5.8e-10	-0.25	0.07	0.08	TRUE
22	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CRTC1	0.33	0.08	lasso	5	0.12	3.6e-05	-4.5	-6.1	1.4e-09	0.04	0.04	0.52	TRUE
8	GTEx	Testis	AC068499.10	0.38	0.41	lasso	3	0.40	6.8e-19	-5.9	-6.0	2.1e-09	-0.41	1.00	0.00	TRUE
21	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IL12RB1	0.07	0.04	blup	58	0.06	4.9e-07	4.4	-6.0	2.7e-09	-0.57	0.88	0.10	TRUE
13	YFS	Blood	KIAA1683	0.51	0.40	enet	65	0.46	9.9e-171	7.7	5.3	1.1e-07	0.05	0.96	0.04	TRUE
24	The Cancer Genome Atlas	Thyroid Carcinoma	MAST3	0.04	0.02	lasso	2	0.00	3.4e-01	8.6	-8.7	3.5e-18	-0.95	0.01	0.91	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	JUND	0.05	0.04	lasso	1	0.04	4.3e-05	7.7	7.8	9.3e-15	0.20	0.02	0.91	FALSE
10	GTEx	Vagina	LRRC25	0.63	0.02	enet	2	0.04	5.3e-02	7.7	-7.7	1.1e-14	-0.20	0.05	0.08	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	JUND	0.04	0.03	lasso	2	0.02	7.9e-04	7.7	7.7	1.9e-14	0.19	0.02	0.90	FALSE
9	GTEx	Thyroid	KIAA1683	0.11	0.07	enet	14	0.12	2.1e-09	5.2	7.3	2.0e-13	0.23	0.94	0.04	FALSE
18	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	JUND	0.11	0.03	blup	58	0.04	1.4e-03	-3.6	7.2	8.7e-13	0.22	0.04	0.12	FALSE
15	The Cancer Genome Atlas	Glioblastoma Multiforme	JUND	0.17	0.00	blup	57	0.03	5.4e-02	7.7	6.9	7.0e-12	0.25	0.01	0.60	FALSE
3	GTEx	Colon Transverse	KIAA1683	0.15	0.02	lasso	3	0.02	3.3e-02	-3.6	6.2	4.5e-10	0.15	0.36	0.09	FALSE
23	The Cancer Genome Atlas	Testicular Germ Cell Tumors	IL12RB1	0.10	0.01	enet	10	0.06	2.6e-03	1.4	-6.2	5.8e-10	-0.62	0.02	0.57	FALSE
11	NTR	Blood	IFI30	0.03	0.02	lasso	6	0.02	8.8e-08	7.7	6.1	9.3e-10	0.31	0.90	0.09	FALSE
7	GTEx	Testis	PDE4C	0.39	0.44	lasso	2	0.43	5.8e-21	-5.9	-5.9	4.1e-09	-0.39	1.00	0.00	FALSE
4	GTEx	Nerve Tibial	KIAA1683	0.25	0.22	lasso	9	0.28	5.2e-20	7.7	5.6	2.4e-08	0.08	0.81	0.19	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAST3	0.04	0.02	blup	65	0.01	7.3e-02	7.8	-5.5	3.4e-08	-0.53	0.01	0.14	FALSE
5	GTEx	Pancreas	AC007192.6	0.19	0.00	enet	28	0.01	1.3e-01	7.8	-5.4	5.4e-08	-0.29	0.07	0.16	FALSE
1	CommonMind	Brain Pre-frontal Cortex	KIAA1683	0.09	0.06	enet	14	0.10	6.6e-12	-3.3	5.4	6.0e-08	0.13	0.99	0.01	FALSE
6	GTEx	Pituitary	KIAA1683	0.43	0.25	lasso	3	0.17	3.9e-05	5.2	5.2	2.0e-07	0.12	0.19	0.06	FALSE