Best TWAS P=1.64e-18 · Best GWAS P=8.37e-19 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | KIAA1683 | 0.09 | 0.06 | enet | 14 | 0.10 | 6.6e-12 | -3.3 | 5.4 | 6.0e-08 | 0.13 | 0.99 | 0.01 | FALSE |
| 2 | GTEx | Colon Transverse | SSBP4 | 0.18 | 0.01 | enet | 21 | 0.00 | 3.6e-01 | 4.6 | -6.2 | 5.8e-10 | -0.25 | 0.07 | 0.08 | TRUE |
| 3 | GTEx | Colon Transverse | KIAA1683 | 0.15 | 0.02 | lasso | 3 | 0.02 | 3.3e-02 | -3.6 | 6.2 | 4.5e-10 | 0.15 | 0.36 | 0.09 | FALSE |
| 4 | GTEx | Nerve Tibial | KIAA1683 | 0.25 | 0.22 | lasso | 9 | 0.28 | 5.2e-20 | 7.7 | 5.6 | 2.4e-08 | 0.08 | 0.81 | 0.19 | FALSE |
| 5 | GTEx | Pancreas | AC007192.6 | 0.19 | 0.00 | enet | 28 | 0.01 | 1.3e-01 | 7.8 | -5.4 | 5.4e-08 | -0.29 | 0.07 | 0.16 | FALSE |
| 6 | GTEx | Pituitary | KIAA1683 | 0.43 | 0.25 | lasso | 3 | 0.17 | 3.9e-05 | 5.2 | 5.2 | 2.0e-07 | 0.12 | 0.19 | 0.06 | FALSE |
| 7 | GTEx | Testis | PDE4C | 0.39 | 0.44 | lasso | 2 | 0.43 | 5.8e-21 | -5.9 | -5.9 | 4.1e-09 | -0.39 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Testis | AC068499.10 | 0.38 | 0.41 | lasso | 3 | 0.40 | 6.8e-19 | -5.9 | -6.0 | 2.1e-09 | -0.41 | 1.00 | 0.00 | TRUE |
| 9 | GTEx | Thyroid | KIAA1683 | 0.11 | 0.07 | enet | 14 | 0.12 | 2.1e-09 | 5.2 | 7.3 | 2.0e-13 | 0.23 | 0.94 | 0.04 | FALSE |
| 10 | GTEx | Vagina | LRRC25 | 0.63 | 0.02 | enet | 2 | 0.04 | 5.3e-02 | 7.7 | -7.7 | 1.1e-14 | -0.20 | 0.05 | 0.08 | FALSE |
| 11 | NTR | Blood | IFI30 | 0.03 | 0.02 | lasso | 6 | 0.02 | 8.8e-08 | 7.7 | 6.1 | 9.3e-10 | 0.31 | 0.90 | 0.09 | FALSE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | JUND | 0.17 | 0.17 | lasso | 5 | 0.20 | 2.7e-25 | 7.7 | 6.4 | 1.3e-10 | 0.13 | 0.93 | 0.07 | TRUE |
| 13 | YFS | Blood | KIAA1683 | 0.51 | 0.40 | enet | 65 | 0.46 | 9.9e-171 | 7.7 | 5.3 | 1.1e-07 | 0.05 | 0.96 | 0.04 | TRUE |
| 14 | YFS | Blood | MAST3 | 0.06 | 0.04 | lasso | 5 | 0.04 | 4.2e-12 | 7.8 | -7.3 | 2.0e-13 | -0.56 | 0.83 | 0.17 | TRUE |
| 15 | The Cancer Genome Atlas | Glioblastoma Multiforme | JUND | 0.17 | 0.00 | blup | 57 | 0.03 | 5.4e-02 | 7.7 | 6.9 | 7.0e-12 | 0.25 | 0.01 | 0.60 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | JUND | 0.05 | 0.04 | lasso | 1 | 0.04 | 4.3e-05 | 7.7 | 7.8 | 9.3e-15 | 0.20 | 0.02 | 0.91 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MAST3 | 0.04 | 0.02 | blup | 65 | 0.01 | 7.3e-02 | 7.8 | -5.5 | 3.4e-08 | -0.53 | 0.01 | 0.14 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | JUND | 0.11 | 0.03 | blup | 58 | 0.04 | 1.4e-03 | -3.6 | 7.2 | 8.7e-13 | 0.22 | 0.04 | 0.12 | FALSE |
| 19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | JUND | 0.04 | 0.03 | lasso | 2 | 0.02 | 7.9e-04 | 7.7 | 7.7 | 1.9e-14 | 0.19 | 0.02 | 0.90 | FALSE |
| 20 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MAST3 | 0.02 | 0.02 | lasso | 3 | 0.01 | 1.5e-02 | 8.6 | -8.8 | 1.6e-18 | -0.95 | 0.01 | 0.96 | TRUE |
| 21 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IL12RB1 | 0.07 | 0.04 | blup | 58 | 0.06 | 4.9e-07 | 4.4 | -6.0 | 2.7e-09 | -0.57 | 0.88 | 0.10 | TRUE |
| 22 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CRTC1 | 0.33 | 0.08 | lasso | 5 | 0.12 | 3.6e-05 | -4.5 | -6.1 | 1.4e-09 | 0.04 | 0.04 | 0.52 | TRUE |
| 23 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | IL12RB1 | 0.10 | 0.01 | enet | 10 | 0.06 | 2.6e-03 | 1.4 | -6.2 | 5.8e-10 | -0.62 | 0.02 | 0.57 | FALSE |
| 24 | The Cancer Genome Atlas | Thyroid Carcinoma | MAST3 | 0.04 | 0.02 | lasso | 2 | 0.00 | 3.4e-01 | 8.6 | -8.7 | 3.5e-18 | -0.95 | 0.01 | 0.91 | FALSE |