Best TWAS P=6.92e-16 · Best GWAS P=1.06e-16 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Testis | PDE4C | 0.39 | 0.44 | lasso | 2 | 0.43 | 5.8e-21 | -5.8 | -5.8 | 5.4e-09 | -0.39 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Testis | AC068499.10 | 0.38 | 0.41 | lasso | 3 | 0.40 | 6.8e-19 | -5.8 | -5.9 | 2.8e-09 | -0.41 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Thyroid | KIAA1683 | 0.11 | 0.07 | enet | 14 | 0.12 | 2.1e-09 | 3.4 | 5.8 | 5.7e-09 | 0.23 | 0.96 | 0.02 | FALSE |
| 4 | GTEx | Vagina | LRRC25 | 0.63 | 0.02 | enet | 2 | 0.04 | 5.3e-02 | 5.7 | -5.6 | 1.7e-08 | -0.20 | 0.05 | 0.07 | FALSE |
| 5 | NTR | Blood | IFI30 | 0.03 | 0.02 | lasso | 6 | 0.02 | 8.8e-08 | 7.0 | 5.3 | 1.1e-07 | 0.31 | 0.87 | 0.12 | FALSE |
| 6 | YFS | Blood | MAST3 | 0.06 | 0.04 | lasso | 5 | 0.04 | 4.2e-12 | 7.1 | -6.7 | 1.7e-11 | -0.56 | 0.90 | 0.10 | FALSE |
| 7 | The Cancer Genome Atlas | Glioblastoma Multiforme | JUND | 0.17 | 0.00 | blup | 57 | 0.03 | 5.4e-02 | 5.7 | 5.8 | 8.9e-09 | 0.25 | 0.01 | 0.59 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | JUND | 0.05 | 0.04 | lasso | 1 | 0.04 | 4.3e-05 | 5.7 | 5.7 | 1.5e-08 | 0.20 | 0.14 | 0.13 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MAST3 | 0.04 | 0.02 | blup | 65 | 0.01 | 7.3e-02 | 7.1 | -5.7 | 1.2e-08 | -0.53 | 0.01 | 0.14 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | JUND | 0.11 | 0.03 | blup | 58 | 0.04 | 1.4e-03 | -3.9 | 6.1 | 8.7e-10 | 0.22 | 0.04 | 0.08 | TRUE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | JUND | 0.04 | 0.03 | lasso | 2 | 0.02 | 7.9e-04 | 5.7 | 5.6 | 2.6e-08 | 0.19 | 0.19 | 0.04 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MAST3 | 0.02 | 0.02 | lasso | 3 | 0.01 | 1.5e-02 | 8.0 | -8.1 | 6.9e-16 | -0.95 | 0.01 | 0.94 | TRUE |
| 13 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IL12RB1 | 0.07 | 0.04 | blup | 58 | 0.06 | 4.9e-07 | 4.3 | -5.2 | 2.5e-07 | -0.57 | 0.88 | 0.10 | FALSE |
| 14 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CRTC1 | 0.33 | 0.08 | lasso | 5 | 0.12 | 3.6e-05 | -3.7 | -5.7 | 1.2e-08 | 0.04 | 0.04 | 0.52 | TRUE |
| 15 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | IL12RB1 | 0.10 | 0.01 | enet | 10 | 0.06 | 2.6e-03 | 1.2 | -6.2 | 7.0e-10 | -0.62 | 0.02 | 0.55 | FALSE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | MAST3 | 0.04 | 0.02 | lasso | 2 | 0.00 | 3.4e-01 | 8.0 | -8.0 | 1.1e-15 | -0.95 | 0.01 | 0.88 | FALSE |