[Hub]/) : Traits : Arm fat-free mass (right) :

chr8:144,201,664-145,818,782

Best TWAS P=4.3e-15 · Best GWAS P=1.41e-13 conditioned to 0.702

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PLEC 0.05 0.07 enet 9 0.07 8.5e-09 -7.3 7.8 4.3e-15 -0.94 0.01 0.99 TRUE
2 GTEx Adipose Subcutaneous PLEC 0.14 0.14 enet 13 0.16 6.2e-13 -7.0 6.6 4.3e-11 -0.94 0.04 0.96 FALSE
3 GTEx Adipose Visceral Omentum PLEC 0.17 0.15 lasso 5 0.18 9.2e-10 -7.2 7.1 1.2e-12 -0.97 0.03 0.97 FALSE
4 GTEx Adipose Visceral Omentum PARP10 0.07 0.03 lasso 4 0.01 6.7e-02 -5.6 6.2 7.7e-10 -0.87 0.06 0.68 FALSE
5 GTEx Adrenal Gland PLEC 0.28 0.16 enet 14 0.19 1.6e-07 -7.1 6.2 5.1e-10 -0.85 0.02 0.97 FALSE
6 GTEx Artery Aorta PLEC 0.18 0.16 lasso 3 0.16 2.6e-09 -7.1 7.2 8.6e-13 -0.94 0.02 0.98 FALSE
7 GTEx Artery Coronary PLEC 0.20 0.03 enet 19 0.07 2.6e-03 -7.1 6.2 6.7e-10 -0.77 0.02 0.68 FALSE
8 GTEx Artery Tibial PLEC 0.19 0.17 lasso 2 0.20 2.2e-15 -7.1 7.2 8.0e-13 -0.95 0.03 0.97 FALSE
9 GTEx Brain Cerebellar Hemisphere PLEC 0.20 0.21 enet 12 0.22 2.2e-06 -6.8 7.6 2.2e-14 -0.94 0.02 0.96 FALSE
10 GTEx Brain Cerebellum PLEC 0.33 0.15 enet 16 0.15 2.6e-05 -7.3 6.7 2.5e-11 -0.95 0.02 0.98 FALSE
11 GTEx Breast Mammary Tissue PLEC 0.17 0.20 lasso 4 0.22 1.3e-11 -7.2 7.2 6.6e-13 -0.97 0.02 0.98 FALSE
12 GTEx Breast Mammary Tissue (Male) PLEC 0.24 0.19 lasso 4 0.18 5.3e-05 -7.0 7.2 6.9e-13 -0.97 0.02 0.94 FALSE
13 GTEx Breast Mammary Tissue (Female) PLEC 0.19 0.17 lasso 2 0.17 7.9e-06 -6.8 7.1 1.1e-12 -0.96 0.03 0.94 FALSE
14 GTEx Cells Transformed fibroblasts PLEC 0.30 0.30 lasso 4 0.40 4.0e-32 -7.2 7.2 6.2e-13 -0.95 0.03 0.97 FALSE
15 GTEx Colon Sigmoid PLEC 0.36 0.06 lasso 2 0.02 5.1e-02 -5.6 6.4 1.4e-10 -0.89 0.10 0.84 FALSE
16 GTEx Colon Sigmoid GPAA1 0.15 0.07 enet 17 0.05 1.0e-02 -7.2 -5.6 1.8e-08 0.83 0.02 0.83 FALSE
17 GTEx Colon Transverse PARP10 0.10 0.04 lasso 8 0.06 9.0e-04 -5.6 6.7 1.9e-11 -0.88 0.10 0.79 FALSE
18 GTEx Esophagus Mucosa PLEC 0.11 0.04 lasso 4 0.05 2.7e-04 -6.6 6.5 6.9e-11 -0.93 0.04 0.94 FALSE
19 GTEx Esophagus Mucosa PARP10 0.08 0.03 enet 17 0.04 1.0e-03 -7.1 7.3 2.3e-13 -0.81 0.04 0.92 FALSE
20 GTEx Esophagus Muscularis PLEC 0.20 0.11 enet 18 0.13 2.3e-08 -7.2 6.7 2.2e-11 -0.86 0.02 0.98 FALSE
21 GTEx Lung PLEC 0.26 0.29 lasso 6 0.30 2.6e-23 -7.1 7.1 1.2e-12 -0.94 0.04 0.96 FALSE
22 GTEx Muscle Skeletal GRINA 0.08 0.06 lasso 5 0.06 3.8e-06 -5.6 -6.6 3.6e-11 0.87 0.15 0.85 FALSE
23 GTEx Nerve Tibial PLEC 0.27 0.30 enet 27 0.38 2.4e-28 -7.0 7.0 3.0e-12 -0.94 0.04 0.96 FALSE
24 GTEx Nerve Tibial PARP10 0.08 0.06 enet 7 0.07 2.2e-05 -6.4 7.4 1.9e-13 -0.85 0.25 0.73 FALSE
25 GTEx Ovary PARP10 0.22 0.05 lasso 4 0.07 6.8e-03 -6.8 7.2 5.6e-13 -0.86 0.03 0.41 FALSE
26 GTEx Pancreas PLEC 0.15 0.10 lasso 3 0.13 3.5e-06 3.9 6.4 2.0e-10 -0.69 0.04 0.93 FALSE
27 GTEx Pituitary PLEC 0.31 0.39 lasso 4 0.44 2.7e-12 -6.8 7.2 7.0e-13 -0.97 0.03 0.97 FALSE
28 GTEx Prostate PLEC 0.22 0.12 lasso 4 0.18 2.7e-05 -7.1 7.2 5.0e-13 -0.92 0.03 0.94 FALSE
29 GTEx Skin Sun Exposed Lower leg PLEC 0.05 0.03 lasso 4 0.03 2.4e-03 -7.2 7.0 2.3e-12 -0.97 0.02 0.91 FALSE
30 GTEx Skin Sun Exposed Lower leg PARP10 0.06 0.04 lasso 3 0.04 1.4e-04 -6.8 7.0 2.4e-12 -0.93 0.07 0.90 FALSE
31 GTEx Testis PLEC 0.25 0.23 lasso 7 0.27 1.9e-12 -7.0 7.3 2.9e-13 -0.97 0.03 0.97 FALSE
32 GTEx Thyroid PLEC 0.20 0.26 lasso 7 0.29 9.2e-23 -6.6 7.1 1.6e-12 -0.95 0.05 0.95 FALSE
33 GTEx Thyroid PARP10 0.08 0.09 enet 6 0.09 4.0e-07 -6.2 6.0 1.9e-09 -0.86 0.88 0.12 FALSE
34 GTEx Thyroid PUF60 0.11 0.05 enet 9 0.09 1.4e-07 -3.4 -5.5 3.5e-08 0.03 0.60 0.05 TRUE
35 GTEx Whole Blood PLEC 0.15 0.15 enet 9 0.19 2.1e-17 -7.3 7.4 1.8e-13 -0.99 0.01 0.99 FALSE
36 METSIM Adipose EPPK1 0.03 0.00 blup 261 0.01 2.3e-02 -7.0 5.3 1.4e-07 -0.66 0.02 0.62 FALSE
37 METSIM Adipose PARP10 0.08 0.13 lasso 4 0.13 1.4e-18 -6.1 6.1 8.6e-10 -0.87 0.63 0.37 FALSE
38 METSIM Adipose PLEC 0.08 0.09 bslmm 256 0.09 1.1e-13 -7.1 6.0 1.9e-09 -0.94 0.01 0.99 FALSE
39 NTR Blood GRINA 0.02 0.03 lasso 5 0.02 1.8e-08 -6.1 6.1 9.5e-10 -0.85 0.10 0.90 FALSE
40 ROSMAP Brain Pre-frontal Cortex PLEC 0.34 0.16 lasso 5 0.16 5.7e-20 -6.8 6.9 6.0e-12 -0.92 0.00 1.00 FALSE
41 ROSMAP Brain Pre-frontal Cortex PARP10 0.10 0.08 lasso 4 0.08 3.7e-10 -6.8 6.0 1.5e-09 -0.88 0.00 1.00 FALSE
42 YFS Blood GRINA 0.37 0.54 enet 14 0.55 2.3e-221 -5.7 6.2 7.3e-10 -0.84 1.00 0.00 FALSE
43 YFS Blood NRBP2 0.21 0.03 bslmm 254 0.06 1.2e-18 -4.2 5.7 1.0e-08 -0.27 1.00 0.00 FALSE
44 YFS Blood PARP10 0.11 0.07 bslmm 235 0.08 1.1e-24 -6.4 5.9 4.4e-09 -0.73 0.85 0.15 FALSE
45 The Cancer Genome Atlas Breast Invasive Carcinoma PLEC 0.03 0.02 lasso 2 0.02 8.9e-05 -6.8 6.7 1.7e-11 -0.92 0.00 1.00 FALSE
46 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PLEC 0.05 0.04 lasso 1 0.03 8.9e-05 -6.8 6.8 8.6e-12 -0.92 0.00 0.99 FALSE
47 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma PLEC 0.06 0.05 enet 2 0.05 1.0e-03 -6.8 6.9 3.8e-12 -0.92 0.00 0.92 FALSE
48 The Cancer Genome Atlas Lung Adenocarcinoma PLEC 0.07 0.05 lasso 1 0.05 8.1e-07 -6.8 6.8 8.6e-12 -0.92 0.00 1.00 FALSE
49 The Cancer Genome Atlas Prostate Adenocarcinoma PLEC 0.02 0.01 blup 4 0.01 1.1e-02 -6.8 7.0 1.8e-12 -0.83 0.00 0.88 FALSE
50 The Cancer Genome Atlas Thyroid Carcinoma PLEC 0.13 0.13 lasso 2 0.13 7.9e-13 -6.8 6.8 8.5e-12 -0.92 0.00 1.00 FALSE