TWAS hub - EPPK1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1650	0.053	6.0e-05	0.101	0.034	0.064	0.093	0.098	2.9e-12	5.0e-05	2.7e-08	1.9e-11	5.4e-12
2	METSIM	Adipose	0.0337	0.020	1.3e-02	-0.001	0.007	0.005	0.007	-0.001	6.2e-01	2.3e-02	5.7e-02	3.0e-02	5.0e-01
3	NTR	Blood	0.0578	0.021	3.5e-05	0.002	0.021	0.022	0.021	0.005	7.5e-02	1.4e-07	1.1e-07	1.6e-07	8.5e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Blood Platelet Count	8.3	96.1	272.2	-0.9	-16.5	-3.9
LDL Cholesterol	6.0	9.5	28.5	0.0	-5.3	0.0
Fasting Glucose	4.9	5.9	8.1	2.9	1.5	2.7
Comparative height size at age 10	3.5	19.5	57.9	-0.8	7.6	0.2
Medication: Bendroflumethiazide	3.3	4.9	7.4	2.7	0.3	2.7
Sitting height	3.1	22.2	54.9	2.8	7.4	2.0
Prostate Cancer	2.7	3.8	4.7	2.2	1.9	1.7
Average weekly fortified wine intake	2.6	3.1	8.6	0.1	2.9	0.8
Pulse rate	2.6	4.4	9.3	0.3	-2.0	-3.1
Standing height	2.6	25.5	75.2	1.0	8.7	0.5
Reason for reducing amount of alcohol drunk: Health precaution	2.6	3.0	5.7	-1.1	2.4	1.5
Cholesterol lowering medication	2.5	3.7	6.2	0.2	-2.5	2.2
Medication for cholesterol	2.4	3.7	4.9	-1.2	2.1	-2.2
Height	2.3	45.0	134.6	0.2	11.6	0.7
Medication: Co-codamol	2.2	2.5	5.7	-1.2	-2.4	-0.7
Medication: Ibuprofen	2.2	2.6	5.9	-2.4	0.2	-1.4
Average weekly red wine intake	2.2	3.2	7.2	-1.5	2.7	-0.2
Pack years adult smoking proportion	2.1	3.2	5.3	-1.9	-0.8	-2.3
Medication: Simvastatin	2.1	3.0	8.4	0.1	-2.9	0.8
Angina (self-reported)	2.1	2.8	4.6	-2.1	1.9	-0.2
Trunk fat-free mass	2.0	11.3	34.0	-0.2	5.8	-0.1
Medication: Omeprazole	2.0	2.3	4.2	-2.0	-0.4	-1.6
Ever taken oral contraceptive pill	2.0	2.2	4.5	-1.2	0.8	-2.1
Unable to work because of sickness or disability	2.0	2.6	3.5	-0.8	-1.9	-1.9
Pack years of smoking	2.0	2.9	4.9	-1.8	-0.7	-2.2
Multivitamins +/- minerals	1.9	2.4	7.1	-0.5	2.7	0.0
Depression (self-reported)	1.9	2.3	4.1	0.2	-2.0	-1.6
Trunk predicted mass	1.9	10.9	32.8	-0.2	5.7	-0.0
Arm predicted mass (right)	1.9	9.9	29.3	-0.6	5.4	-0.1
Hypertension (Self-reported)	1.9	5.2	10.2	2.3	-0.0	3.2
Average weekly champagne plus white wine intake	1.9	2.6	3.3	-1.4	1.6	-1.8
Angina	1.8	2.4	4.2	-2.0	1.7	-0.2
High blood pressure (mother)	1.8	2.5	5.0	2.2	-1.2	1.0
Length of working week for main job	1.8	2.0	2.9	-1.2	-1.3	-1.7
Arm fat-free mass (right)	1.8	9.4	27.7	-0.5	5.3	-0.4
Commuting to job workplace: Public transport	1.8	2.1	3.1	-0.6	1.8	-1.7
High cholesterol (Self-reported)	1.8	3.3	8.3	-0.1	-2.9	1.3
Arm fat-free mass (left)	1.8	9.2	27.1	-0.6	5.2	-0.2
Supplements: Glucosamine	1.7	2.2	3.4	1.8	1.6	0.8
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	3.7	-1.2	-1.9	-1.0
Medication: Ventolin 100micrograms inhaler	1.7	2.2	5.6	2.4	1.0	0.4
High blood pressure	1.6	4.4	7.6	2.4	0.0	2.8
Medication: Cholesterol lowering	1.6	2.5	6.4	-1.0	-2.5	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	4.9	0.5	-2.2	-0.6
Arm predicted mass (left)	1.6	8.0	23.8	-0.5	4.9	-0.1
Chronic bronchitis/emphysema (mother)	1.5	1.7	2.7	-1.0	1.6	1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.1	6.9	1.2	2.6	0.9
Back pain experienced in last month	1.5	2.3	5.3	-1.1	-2.3	0.4
Asthma (self-reported)	1.5	3.0	5.7	0.5	1.7	2.4
Schizophrenia (2018)	1.4	3.0	8.9	0.0	-3.0	0.1
Sensitivity / hurt feelings	1.4	2.3	6.2	2.5	0.2	0.9
Nervous feelings	1.4	2.6	5.2	2.3	-1.5	0.6
Overall health rating	1.4	2.9	6.4	-1.1	-2.5	-1.1
Knee pain experienced in last month	1.4	2.2	3.0	-1.7	1.2	1.4
Loneliness, isolation	1.4	1.9	4.7	2.2	-0.4	0.9
Long-standing illness, disability or infirmity	1.4	2.2	5.9	-0.2	-2.4	-0.8
Medication: Blood pressure	1.4	2.7	4.0	1.7	-1.1	2.0
Medication: Lisinopril	1.4	1.8	2.5	1.2	1.2	1.6
Waist Hip Ratio (WHR)	1.3	5.9	11.6	-1.5	3.4	-2.0
Cardiovascular Disease	1.3	4.2	8.1	2.9	-0.1	2.1
Respiratory disease	1.3	2.9	4.6	-0.4	2.1	2.0
Alcohol intake versus 10 years previously	1.3	1.9	3.4	-0.1	-1.8	1.6
Falls in the last year	1.3	1.7	5.0	0.2	-2.2	0.4
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	4.0	0.6	0.0	2.0
Birth weight of first child	1.3	2.3	5.1	-0.9	2.3	-1.0
Loud music exposure frequency	1.3	1.4	2.4	-1.5	0.9	-1.0
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	6.3	0.3	2.5	1.1
High blood pressure (siblings)	1.3	1.9	4.2	2.1	0.8	0.9
Pulse wave peak to peak time	1.3	1.5	3.7	-0.6	0.7	1.9
Pulse rate, automated reading	1.3	4.1	9.5	1.3	-1.1	-3.1
Medication: Aspirin	1.3	1.8	3.6	-1.0	-0.9	1.9
Whole body fat-free mass	1.3	7.4	22.0	-0.4	4.7	-0.0
Whole body water mass	1.3	7.3	21.7	-0.4	4.7	-0.1
Mother’s age at death	1.3	1.6	3.9	-0.4	2.0	-0.8
Vascular/heart problems diagnosed by doctor	1.3	3.5	7.5	-1.7	-0.2	-2.7
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	1.8	-1.4	-1.1	-1.3
Qualifications: CSEs or equivalent	1.2	1.6	3.3	1.8	0.9	0.9
Serious illness, injury or assault to yourself	1.2	1.5	2.4	-1.3	-1.5	0.6
Number of incorrect matches in round	1.2	1.9	3.6	1.4	0.6	1.9
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	5.1	1.1	1.5	2.3
Number of live births	1.2	1.8	3.4	-1.0	-0.9	1.9
Heart disease (mother)	1.2	1.5	2.8	-0.9	-1.7	0.9
Suffer from ‘nerves’	1.2	1.9	3.2	1.5	-1.8	0.6
Illnesses of siblings: Diabetes	1.2	1.5	3.0	0.0	1.2	-1.7
Osteoporosis (self-reported)	1.2	1.5	3.9	-0.4	-2.0	0.7
Pain type(s) experienced in last month: Hip pain	1.2	1.6	2.7	-1.6	-1.0	0.9
Medication: Atorvastatin	1.2	1.4	2.3	-1.5	-1.3	-0.5
Age started oral contraceptive pill	1.2	1.5	2.3	-1.2	1.5	-0.9
Schizophrenia vs Biploar Disorder	1.1	1.5	4.5	0.0	2.1	0.0
Reaction Time	1.1	2.1	5.2	-0.1	-1.0	2.3
Age when periods started (menarche)	1.1	2.6	4.5	-0.4	2.1	-1.7
Alcohol usually taken with meals	1.1	1.8	4.9	-2.2	0.6	0.4
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	5.0	-0.3	-2.2	-0.2
Financial difficulties in last 2 years	1.1	1.5	2.4	1.6	-1.0	-1.0
Father’s age at death	1.1	1.4	2.6	-1.0	0.9	-1.6
Asthma	1.1	2.2	4.8	0.3	1.4	2.2
Health satisfaction	1.1	1.5	4.2	-0.4	-0.2	-2.0
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	2.3	-0.7	1.5	-1.1
Basal metabolic rate	1.1	5.8	17.1	-0.7	4.1	-0.1
Commuting to job workplace: Cycle	1.1	1.3	2.2	-1.3	0.2	-1.5
Chronic bronchitis/emphysema (father)	1.0	1.2	2.1	0.4	-1.5	1.1
Worrier / anxious feelings	1.0	1.9	4.8	2.2	-0.6	0.7
Hair/balding pattern: Pattern 3	1.0	1.5	2.4	-1.6	-1.4	-0.1
Qualifications: A levels/AS levels or equivalent	1.0	2.2	3.8	-1.0	1.9	-1.4
Pulse wave Arterial Stiffness index	1.0	1.2	3.1	0.7	-0.1	-1.8
Qualifications: College or University degree	1.0	3.2	7.1	-0.7	2.7	-1.4
Migraine (self-reported)	1.0	1.3	2.0	-1.4	-0.9	-1.0
Commuting to job workplace: Car/motor vehicle	1.0	1.1	3.1	-0.3	-1.8	-0.4
Illnesses of father: Heart disease	1.0	1.3	1.8	-1.0	-1.1	1.3
Illnesses of father: None of the above (group 1)	1.0	1.3	3.3	0.8	0.0	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	5.6	-0.5	-2.4	-0.9
Ovarian Cancer	0.9	1.2	3.5	1.9	0.0	0.1
Age at First Birth	0.9	1.3	3.3	-0.7	0.3	-1.8
Lupus	0.9	1.3	2.7	-1.7	0.7	0.8
Blood White Count	0.9	6.6	12.7	-0.6	-2.6	-3.6
Type 2 Diabetes (T2D) (2018)	0.9	1.6	3.3	1.1	1.8	-0.6
Hand grip strength (left)	0.9	2.4	6.8	0.5	2.6	-0.3
Hearing difficulty/problems: Yes	0.9	1.3	2.3	-1.1	1.5	-0.6
Had menopause	0.9	1.1	3.0	1.7	0.2	-0.6
Diabetes (self-reported)	0.9	1.4	2.2	0.9	1.5	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	2.8	0.5	-1.7	0.5
Medication: Blood pressure	0.9	1.6	3.9	0.7	0.5	2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	3.1	-0.0	-1.8	-0.4
Financial situation satisfaction	0.9	1.2	2.7	1.6	-0.9	0.1
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.1	-1.2	0.0	-1.4
Blood Red Count	0.8	7.7	21.8	0.2	4.7	-1.1
Hypothyroidism (self reported)	0.8	1.8	4.0	0.1	2.0	1.1
Lung FVC	0.8	4.2	6.9	-1.9	-2.6	-1.4
Tanning	0.8	9.6	24.8	-2.0	5.0	0.4
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.0	-1.1	-1.4	0.2
Vitamin and mineral supplements	0.8	1.1	2.8	0.6	-1.7	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.7	1.2	0.7	1.9
Medication: Levothyroxine sodium	0.8	1.3	3.7	-0.2	1.9	0.5
Hair/balding pattern: Pattern 2	0.8	1.1	2.9	-0.4	1.7	-0.2
Heart attack	0.8	1.0	1.7	-1.1	0.1	-1.3
Pain all over the body in last month	0.8	0.8	1.2	0.4	1.1	-1.1
Shortness of breath walking on level ground	0.8	0.9	1.2	0.8	-1.1	-0.9
Chest pain or discomfort	0.8	1.2	3.1	-1.8	0.6	0.4
Age at last live birth	0.8	1.2	2.7	-1.6	0.1	-0.9
Leg pain on walking	0.8	1.0	1.5	0.5	-1.2	-1.1
Arm fat percentage (left)	0.8	3.3	7.4	-1.5	-2.7	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.2	-1.5	-0.0	0.7
Eye problems/disorders: Cataract	0.8	0.9	2.0	-0.5	-0.7	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.0	0.6	-0.6	1.7
Mineral and other dietary supplements	0.8	1.0	1.7	-1.2	-1.3	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.9	0.1	-1.4	1.0
Bipolar Disorder or Schizophrenia	0.7	1.7	5.1	0.0	-2.3	0.0
Depressed Affect (Nagel 2018)	0.7	1.4	3.6	1.9	0.5	0.7
Alzheimer’s Disease (in father)	0.7	0.7	2.2	-0.1	1.5	0.2
Verbal and Numeric Reasoning (VNR)	0.7	1.6	2.8	1.7	0.7	-1.3
Body Mass Index (BMI) (2010)	0.7	1.0	2.0	0.0	1.0	1.4
Neuroticism (2016)	0.7	1.1	1.4	0.9	1.2	1.0
Primary Biliary Cirrhosis	0.7	1.0	1.6	0.9	0.7	1.3
Ever used hormone-replacement therapy (HRT)	0.7	0.8	1.1	-0.8	-0.9	1.1
Medication for hormone replacement therapy	0.7	0.8	2.0	0.6	-1.4	-0.3
Severe depression (siblings)	0.7	0.8	1.1	0.7	-0.9	1.0
Hand grip strength (right)	0.7	1.8	5.2	0.3	2.3	-0.4
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	1.4	-1.2	0.1	-1.1
Medication: Atenolol	0.7	0.9	2.4	-1.5	0.4	0.5
Neuroticism score	0.7	1.4	3.6	1.9	0.1	0.7
Arm fat percentage (right)	0.7	2.8	6.4	-1.3	-2.5	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.2	-1.5	0.3	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	1.9	0.5	-1.4	1.0
Emphysema/chronic bronchitis	0.7	0.7	1.1	-1.1	-0.2	-1.0
Medication for pain relief, constipation, heartburn	0.7	1.2	2.1	1.5	1.2	-0.3
Supplements: Vitamin C	0.7	0.8	2.3	-1.5	0.4	0.2
Medication: Aspirin	0.7	0.9	2.2	-0.7	-0.3	1.5
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.4	-0.3	0.2	1.6
Myopia	0.7	1.0	2.0	-0.2	1.4	-1.0
Crohns Disease (2012)	0.6	1.0	1.2	-1.0	1.1	-1.0
Rheumatoid Arthritis	0.6	0.9	1.9	-1.4	-0.6	0.5
Supplements: Zinc	0.6	0.7	1.5	-1.2	0.0	0.7
Maternal smoking around birth	0.6	0.9	2.5	-0.2	1.6	0.5
Weight	0.6	3.1	8.3	-1.0	2.9	-0.1
Noisy workplace	0.6	0.7	1.8	-0.4	-0.5	-1.3
Mouth/teeth dental problems: Dentures	0.6	1.1	2.6	-0.7	0.1	-1.6
Exposure to tobacco smoke at home	0.6	0.7	1.7	-0.2	-1.3	-0.5
Breastfed as a baby	0.6	0.8	1.1	-0.6	-1.0	-1.0
Birth weight	0.6	1.4	3.4	-1.8	0.4	-0.7
Age at first live birth	0.6	1.0	1.6	-0.9	-0.8	-1.3
Medication: Allopurinol	0.6	0.8	2.2	-0.2	1.5	0.3
Mean time to correctly identify matches	0.6	1.2	3.3	-0.3	0.4	1.8
Had major operations	0.6	0.7	1.3	-1.1	-0.8	0.4
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.4	0.4	1.2	-0.8
Diabetes diagnosed by doctor	0.6	1.0	1.3	1.1	1.1	-0.8
Number of self-reported non-cancer illnesses	0.6	1.1	2.2	0.0	-1.5	1.0
Wears glasses or contact lenses	0.6	0.7	1.5	-0.1	1.2	-0.7
Average weekly beer plus cider intake	0.6	0.8	1.9	0.4	-0.6	-1.4
Neuroticism (Nagel 2018)	0.5	1.1	3.2	1.8	0.1	0.4
Worry (Nagel 2018)	0.5	1.1	1.9	1.4	-1.2	-0.3
Alzheimer’s Disease (in mother)	0.5	0.5	1.3	-1.2	-0.2	0.4
Crohns Disease (2017)	0.5	1.1	2.7	0.0	1.6	0.8
Breast Cancer	0.5	1.3	2.5	0.2	1.6	-1.2
Neuroticism	0.5	1.1	2.3	1.5	-0.2	1.1
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.3	0.4	-1.1	-0.3
Diabetes (father)	0.5	0.7	1.2	-0.5	-1.1	-0.7
Leg fat-free mass (left)	0.5	2.5	6.8	-0.8	2.6	-0.1
Relative age voice broke	0.5	0.8	1.1	-1.0	1.1	-0.6
Leg predicted mass (left)	0.5	2.4	6.6	-0.7	2.6	-0.1
Fluid intelligence score	0.5	1.0	2.0	0.8	0.6	-1.4
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.0	-1.0	0.1	-0.9
Blood clot in the leg (DVT)	0.5	0.6	1.0	-0.0	-1.0	0.9
Gout (self-reported)	0.5	0.7	1.7	0.2	1.3	0.6
Comparative body size at age 10	0.5	1.3	3.7	-1.9	0.3	0.2
Number of full brothers	0.5	0.7	1.3	1.2	-0.6	0.6
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.2	-1.1	-0.9	0.1
Neck or shoulder pain in last month	0.5	0.8	2.1	-0.2	-0.4	-1.4
Alcohol intake frequency.	0.5	1.3	2.5	0.6	-1.6	1.0
Family relationship satisfaction	0.5	0.6	1.1	-0.4	0.8	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.5	-0.1	0.5	1.2
Mood swings	0.5	0.8	2.1	0.3	1.5	0.5
Heart disease (siblings)	0.5	0.6	1.5	-1.2	0.2	0.4
Mean Putamen Volume	0.4	0.4	0.9	-0.1	-0.9	0.6
Heel T-Score	0.4	3.3	9.2	0.8	0.3	3.0
Lung FEV1/FVC ratio	0.4	1.8	4.9	-0.3	-2.2	-0.6
Ever had hysterectomy (womb removed)	0.4	0.4	0.9	-0.6	0.9	0.2
Systolic blood pressure, automated reading	0.4	1.0	2.9	1.7	0.4	0.1
Medication: Metformin	0.4	0.6	1.3	-0.3	0.5	-1.1
Townsend deprivation index at recruitment	0.4	0.5	0.8	0.8	-0.4	0.9
Fed-up feelings	0.4	0.7	2.0	1.4	0.4	0.3
Waist circumference	0.4	1.6	2.1	-1.5	1.0	-1.3
Had other major operations	0.4	0.5	0.9	-0.4	0.9	-0.6
Lung cancer (father)	0.4	0.4	0.7	0.8	-0.2	0.7
Impedance of arm (left)	0.4	1.8	5.2	0.4	-2.3	0.3
Leg fat-free mass (right)	0.4	2.3	6.6	-0.4	2.6	0.3
Ever had bowel cancer screening	0.4	0.4	1.0	0.4	-1.0	-0.2
Friendships satisfaction	0.4	0.5	1.4	0.0	1.2	0.1
Qualifications: nursing, teaching	0.4	0.7	2.0	0.2	0.2	1.4
Leg predicted mass (right)	0.4	2.1	6.2	-0.4	2.5	0.3
Miserableness	0.4	0.7	1.8	0.4	1.4	0.0
Guilty feelings	0.4	0.5	0.8	-0.7	0.6	0.9
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.4	1.2	-0.0	-0.2
Ever depressed for a whole week	0.4	0.5	0.7	0.8	-0.8	0.3
Depression (Nagel 2018)	0.3	0.4	1.0	0.6	-0.0	1.0
BMI	0.3	1.7	2.8	-1.7	-0.5	-1.4
Systolic Blood Pressure	0.3	1.4	2.6	1.3	1.6	0.2
Relative age of first facial hair	0.3	0.7	1.5	-0.3	0.7	1.2
Diabetes (mother)	0.3	0.4	0.7	-0.6	0.8	0.5
Trunk fat percentage	0.3	1.3	2.9	-1.7	-0.7	-0.8
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.8	-0.9	-0.2	0.2
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.1	0.6	0.5	-1.0
Body mass index (BMI)	0.3	1.2	2.5	-1.6	-1.0	-0.3
Impedance of leg (left)	0.3	1.3	3.1	0.9	1.8	-0.2
Trunk fat mass	0.3	1.3	2.6	-1.6	0.9	-0.8
Past tobacco smoking	0.3	0.5	0.9	-0.9	-0.2	0.7
Forced vital capacity (FVC)	0.3	1.1	2.7	-0.4	1.6	0.6
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	0.7	-0.2	0.5	-0.8
Medication: Ramipril	0.3	0.4	0.9	0.9	0.2	0.5
Impedance of arm (right)	0.3	1.6	4.3	0.7	-2.1	0.0
Peak expiratory flow (PEF)	0.3	0.8	2.4	0.1	-0.0	1.6
Pulse wave reflection index	0.3	0.4	1.2	-0.1	1.1	0.1
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.8	-0.2	0.8	-0.9
Body fat percentage	0.3	1.2	2.0	-1.4	-1.0	-0.8
Leg fat percentage (right)	0.3	1.1	2.0	-1.4	-0.5	-1.0
Exposure to tobacco smoke outside home	0.3	0.4	0.6	-0.7	-0.3	-0.7
Eye problems/disorders: None of the above	0.3	0.4	0.8	0.6	0.9	0.1
Medication: Seretide 50 evohaler	0.3	0.3	0.5	0.5	-0.7	0.4
Leg fat mass (right)	0.3	1.3	2.4	-1.6	0.8	-0.9
Number of full sisters	0.3	0.3	0.6	-0.8	-0.6	0.1
Smoking status: Previous	0.3	0.4	0.7	0.7	0.3	-0.8
Medication: Gliclazide	0.3	0.4	1.0	0.0	0.5	-1.0
Illnesses of father: High blood pressure	0.3	0.4	0.9	-0.1	-1.0	0.5
Number of operations (self-reported)	0.3	0.4	0.9	-0.9	-0.2	-0.6
Risk taking	0.3	0.4	0.9	-0.6	-0.9	0.0
Pain experienced in last month	0.3	0.5	1.3	0.4	0.5	-1.1
Basal cell carcinoma (self-reported)	0.3	0.3	0.4	-0.6	-0.6	-0.4
Alcohol drinker status: Previous	0.3	0.4	0.5	-0.7	-0.6	-0.6
Alzheimer’s Disease (including proxy)	0.2	0.3	0.5	-0.1	0.5	0.7
Ulcerative Colitis (UC)	0.2	0.3	0.5	0.4	-0.7	-0.5
HbA1C	0.2	0.3	0.6	-0.0	0.5	0.7
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.8	0.0	0.9	0.0
Ulcerative Colitis	0.2	0.2	0.7	0.0	-0.1	-0.8
Smoking Status	0.2	0.4	1.1	1.1	-0.1	-0.4
Allergy or Eczema	0.2	0.5	1.4	0.2	0.1	-1.2
Chronotype (morning person)	0.2	0.5	0.8	0.8	-0.1	0.9
Number of treatments/medications taken	0.2	0.4	1.0	-0.3	-1.0	-0.2
Average weekly spirits intake	0.2	0.3	0.5	-0.7	-0.4	0.5
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.3	0.5	0.2	0.6
Impedance of leg (right)	0.2	1.0	2.5	0.2	1.6	-0.7
Current tobacco smoking	0.2	0.3	0.6	0.8	-0.4	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	-0.7	-0.2	0.6
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	0.3	0.8	0.1
Stomach or abdominal pain in last month	0.2	0.3	0.4	0.6	0.5	0.5
Qualifications: None of the above	0.2	0.4	1.0	-0.3	-1.0	-0.0
Mouth/teeth dental problems	0.2	0.4	0.9	0.3	1.0	0.3
Allergy	0.2	0.4	1.1	-0.4	-1.0	-0.0
Time employed in main current job	0.2	0.3	0.8	-0.1	-0.1	-0.9
Prospective memory result	0.2	0.2	0.6	0.1	-0.8	0.3
Arm fat mass (right)	0.2	0.7	1.9	-1.4	-0.3	-0.4
Tense / ‘highly strung’	0.2	0.4	0.7	0.8	0.6	0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.8	0.1	0.0	-0.9
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.6	0.8	0.2	0.4
Headache pain in last month	0.2	0.3	0.8	-0.1	0.1	0.9
Glaucoma (self-reported)	0.2	0.3	0.4	-0.0	0.6	0.7
Worry too long after embarrassment	0.2	0.3	0.6	0.5	0.8	-0.1
Wheeze or whistling in the chest in last year	0.2	0.4	0.8	-0.6	0.9	0.2
Number of children fathered	0.2	0.2	0.3	0.4	-0.6	-0.3
Whole body fat mass	0.2	1.0	1.9	-1.4	0.7	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.3	-0.4	-0.5	0.6
Osteoarthritis (self-reported)	0.2	0.3	0.6	-0.0	-0.5	0.8
Smoking status: Current	0.2	0.3	0.4	0.6	-0.5	0.5
Arm fat mass (left)	0.2	0.7	1.9	-1.4	-0.3	-0.3
Medication: Paracetamol	0.2	0.4	0.6	-0.7	-0.8	-0.1
Alcohol drinker status: Never	0.2	0.2	0.6	-0.8	-0.1	-0.1
Ever smoked	0.2	0.4	0.9	0.4	0.4	-1.0
Leg fat percentage (left)	0.2	0.5	1.1	-1.0	-0.3	-0.7
Irritability	0.2	0.3	0.6	0.4	-0.4	-0.8
Fractured/broken bones in last 5 years	0.2	0.3	0.5	-0.5	-0.3	-0.7
Diastolic blood pressure, automated reading	0.2	0.6	1.4	1.2	-0.3	0.6
Supplements: Calcium	0.2	0.2	0.4	0.4	0.6	0.3
Leg fat mass (left)	0.2	0.9	1.5	-1.2	0.8	-0.7
Bipolar Disorder (2018)	0.1	0.2	0.5	0.0	0.2	-0.7
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.5	0.7	0.3	-0.7
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	0.0	0.7	0.2
Blood Eosinophil Count	0.1	0.6	1.3	0.4	-1.1	0.5
Hair Pigment	0.1	2.0	3.1	1.6	-0.4	1.8
Taking other prescription medications	0.1	0.1	0.3	-0.2	-0.5	0.1
Hearing difficulty/problems with background noise	0.1	0.2	0.4	-0.2	0.6	0.3
Illnesses of siblings	0.1	0.2	0.5	0.1	-0.7	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	-0.2	-0.8	0.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.4	-0.4	0.6	0.6
Medication: Lansoprazole	0.1	0.2	0.3	0.3	-0.3	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.5	-0.7	-0.7	0.1
Medication: Paracetamol	0.1	0.2	0.5	0.2	-0.7	0.3
Medication: Amlodipine	0.1	0.1	0.1	0.3	0.1	-0.4
Forced vital capacity (FVC), Best measure	0.1	0.4	0.8	-0.7	0.9	-0.1
Commuting to job workplace: Walk	0.1	0.1	0.2	0.4	0.3	0.5
Hearing aid user	0.1	0.1	0.2	0.0	0.1	0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	-0.4	-0.1	-0.5
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	0.6	-0.1	0.3
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.1	0.2	0.0	0.2	0.4
Schizophrenia (2014)	0.0	0.1	0.2	0.0	-0.4	0.3
Triglycerides	0.0	0.1	0.1	0.0	-0.3	-0.4
Hip circumference	0.0	0.0	0.1	-0.2	-0.2	-0.1
Happiness	0.0	0.0	0.0	-0.1	0.2	-0.2
Illnesses of mother	0.0	0.0	0.0	-0.0	0.1	-0.2
Hair/balding pattern: Pattern 4	0.0	0.0	0.1	0.0	0.2	-0.0
Breast cancer (self-reported)	0.0	0.1	0.2	0.0	-0.4	0.0
Impedance of whole body	0.0	0.2	0.3	0.5	-0.5	-0.0

Hub : Genes

EPPK1

Models

Trait associations