TWAS hub - PUF60

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Thyroid	0.107	0.040	5.7e-04	0.050	NA	0.093	NA	0.067	9.6e-05	NA	1.4e-07	NA	7.9e-06
2	TCGA	Thyroid Carcinoma	0.121	0.072	1.7e-06	0.074	0.075	0.073	NA	0.073	1.1e-07	9.2e-08	1.2e-07	NA	1.4e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Prostate Cancer	11.1	15.7	17.8	-3.7	-4.2
Hip circumference	7.1	30.4	44.2	-6.7	-4.1
Number of live births	5.4	7.6	8.5	2.6	2.9
Weight	5.3	25.9	40.1	-6.3	-3.4
Leg fat mass (left)	5.3	20.8	31.9	-5.6	-3.1
Whole body fat mass	5.2	21.9	34.2	-5.8	-3.1
Trunk fat mass	5.1	21.9	35.1	-5.9	-2.9
Leg fat mass (right)	5.0	19.4	29.4	-5.4	-3.1
Commuting to job workplace: Walk	5.0	5.4	6.7	2.6	2.0
Arm fat mass (right)	4.9	20.1	30.5	-5.5	-3.1
Arm fat mass (left)	4.9	20.3	30.7	-5.5	-3.2
Depression (self-reported)	4.8	5.8	7.7	2.0	2.8
Medication: Ventolin 100micrograms inhaler	4.8	6.2	7.9	-2.8	-2.1
Arm fat-free mass (left)	4.8	24.4	34.9	-5.9	-3.7
Heart attack/myocardial infarction (self-reported)	4.6	6.0	9.2	-3.0	-1.7
Asthma (self-reported)	4.5	9.0	9.2	-3.0	-3.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.4	5.2	7.7	1.6	2.8
Heart attack	4.3	5.6	9.0	-3.0	-1.4
Waist circumference	4.2	15.5	24.6	-5.0	-2.5
Arm predicted mass (left)	4.2	21.4	31.1	-5.6	-3.4
Serious illness, injury or assault to yourself	4.1	5.0	9.4	-3.1	-0.8
Arm predicted mass (right)	4.1	21.2	31.3	-5.6	-3.3
Basal metabolic rate	4.1	22.6	35.4	-6.0	-3.1
Schizophrenia (2014)	4.0	8.9	17.8	4.2	0.0
Arm fat-free mass (right)	4.0	20.3	30.4	-5.5	-3.2
Trunk predicted mass	3.9	22.1	31.4	-5.6	-3.6
Medication: Cholesterol lowering	3.8	6.0	7.3	-2.2	-2.7
Whole body fat-free mass	3.8	21.6	33.9	-5.8	-3.1
Medication: Co-codamol	3.7	4.3	6.2	1.5	2.5
Trunk fat-free mass	3.7	21.4	30.9	-5.6	-3.5
Whole body water mass	3.7	21.2	32.9	-5.7	-3.1
Leg fat-free mass (left)	3.6	19.0	31.9	-5.6	-2.5
Leg predicted mass (left)	3.6	19.2	32.1	-5.7	-2.5
Asthma	3.6	7.1	7.3	-2.7	-2.6
Birth weight	3.6	7.9	8.2	-2.7	-2.9
Medication: Atorvastatin	3.6	4.4	5.1	-1.9	-2.2
Eye problems/disorders: Diabetes related eye disease	3.5	3.8	7.1	-2.7	-0.8
Arm fat percentage (right)	3.5	13.8	21.1	-4.6	-2.5
Leg fat percentage (left)	3.5	12.8	19.3	-4.4	-2.5
Body fat percentage	3.4	13.6	21.9	-4.7	-2.3
Leg fat-free mass (right)	3.4	17.9	30.5	-5.5	-2.3
Trunk fat percentage	3.3	13.4	22.3	-4.7	-2.1
Body mass index (BMI)	3.3	14.1	21.3	-4.6	-2.6
Gout (self-reported)	3.3	4.5	5.3	-2.3	-1.9
Leg predicted mass (right)	3.3	17.8	30.4	-5.5	-2.3
Arm fat percentage (left)	3.2	12.6	20.2	-4.5	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	3.2	3.4	5.3	2.3	1.2
Leg fat percentage (right)	3.0	11.0	16.0	-4.0	-2.5
Mouth/teeth dental problems: Mouth ulcers	3.0	4.7	8.1	2.8	1.1
Stomach or abdominal pain in last month	2.9	3.6	4.7	1.6	2.2
Respiratory disease	2.8	6.2	7.1	-2.7	-2.3
Commuting to job workplace: Public transport	2.8	3.3	3.4	1.8	1.9
Schizophrenia (2018)	2.6	5.4	10.8	3.3	0.0
BMI	2.6	15.1	21.9	-4.7	-2.9
Relative age of first facial hair	2.6	5.4	6.5	2.1	2.5
Lung cancer (father)	2.6	3.1	3.9	-2.0	-1.5
Risk taking	2.6	3.8	7.6	-2.8	-0.2
Hearing difficulty/problems with background noise	2.5	4.1	5.9	-2.4	-1.5
Number of children fathered	2.5	2.8	3.7	-1.9	-1.4
Bipolar Disorder or Schizophrenia	2.4	5.9	11.9	3.4	0.0
Medication for hormone replacement therapy	2.3	2.6	2.8	-1.7	-1.6
Comparative body size at age 10	2.3	6.3	9.5	-3.1	-1.7
Wheeze or whistling in the chest in last year	2.3	4.0	4.1	-2.0	-2.0
Medication: Aspirin	2.3	3.0	3.4	-1.6	-1.8
Other serious medical condition/disability diagnosed by doctor	2.2	2.8	5.4	0.6	2.3
Emphysema/chronic bronchitis	2.2	2.5	3.4	-1.3	-1.8
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.7	3.8	1.9	1.3
Loud music exposure frequency	2.1	2.3	4.4	-2.1	-0.5
High blood pressure (siblings)	2.1	3.0	4.2	-1.3	-2.1
Comparative height size at age 10	2.1	11.3	13.4	-3.7	-3.0
Worry (Nagel 2018)	1.9	4.1	6.8	2.6	1.2
Body Mass Index (BMI) (2010)	1.9	2.6	5.2	-2.3	0.0
Mean Putamen Volume	1.8	2.1	4.2	2.0	0.0
Height	1.8	35.0	47.6	-6.9	-4.7
Hand grip strength (right)	1.8	4.9	7.9	-1.4	-2.8
Heel bone mineral density (BMD) T-score, automated (left)	1.8	4.1	7.8	0.7	2.8
Medication: Atenolol	1.8	2.3	2.8	-1.4	-1.7
Illnesses of siblings	1.8	2.5	3.4	1.3	1.8
Medication for cholesterol, blood pressure or diabetes	1.8	3.1	4.7	1.2	2.2
Medication: Ibuprofen	1.8	2.1	3.0	1.7	1.1
Vascular/heart problems diagnosed by doctor	1.8	4.9	6.5	2.6	1.8
Taking other prescription medications	1.7	2.7	5.3	-2.3	-0.3
Medication: Levothyroxine sodium	1.6	2.7	4.1	-2.0	-1.2
Hair/balding pattern: Pattern 2	1.6	2.0	3.2	-1.8	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.6	5.6	1.3	2.4
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	3.8	-1.9	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	2.5	1.6	1.2
Smoking status: Previous	1.6	2.4	3.5	-1.1	-1.9
Pain experienced in last month	1.6	2.6	5.2	2.3	0.3
Diabetes (mother)	1.5	1.9	3.6	0.4	1.9
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	2.1	-1.4	-1.0
Qualifications: O levels/GCSEs or equivalent	1.5	2.3	3.7	1.0	1.9
Crohns Disease (2012)	1.4	2.2	4.4	-2.1	0.0
Number of treatments/medications taken	1.4	2.6	4.2	-2.0	-1.0
Average weekly fortified wine intake	1.4	1.6	3.2	-1.8	-0.0
Sitting height	1.4	9.8	14.9	-3.9	-2.1
Hair/balding pattern: Pattern 4	1.4	3.5	3.8	-1.9	-1.8
Hypothyroidism/myxoedema (self-reported)	1.4	2.8	4.8	-2.2	-0.9
Number of full sisters	1.4	1.7	2.1	-1.1	-1.5
Commuting to job workplace: Car/motor vehicle	1.4	1.6	2.5	-1.6	-0.9
Alzheimer’s Disease (including proxy)	1.3	1.9	2.2	-1.5	-1.2
Angina	1.3	1.8	2.5	-1.6	-1.0
Nervous feelings	1.3	2.4	4.7	2.2	0.2
Standing height	1.3	13.2	20.8	-4.6	-2.4
Birth weight of first child	1.3	2.4	3.6	-1.9	-1.1
Angina (self-reported)	1.3	1.8	2.5	-1.6	-1.0
Supplements: Vitamin C	1.3	1.5	1.8	-1.4	-1.1
Average weekly red wine intake	1.3	1.9	2.5	-1.6	-1.1
Osteoarthritis (self-reported)	1.3	1.6	2.4	-1.6	-0.9
Wears glasses or contact lenses	1.3	1.5	2.9	-1.7	-0.3
Ever taken oral contraceptive pill	1.3	1.4	2.8	0.2	1.7
Pain type(s) experienced in last month: Hip pain	1.3	1.6	3.0	-1.7	-0.5
HDL Cholesterol	1.2	1.9	3.9	2.0	0.0
Hypothyroidism (self reported)	1.2	2.8	4.5	-2.1	-1.1
Hand grip strength (left)	1.2	3.0	4.9	-1.1	-2.2
Diabetes (father)	1.2	1.5	2.5	0.8	1.6
High blood pressure	1.2	3.3	3.9	-2.0	-1.7
Past tobacco smoking	1.2	2.2	2.6	1.3	1.6
Medication: Lansoprazole	1.2	1.3	2.3	-1.5	-0.6
Exposure to tobacco smoke at home	1.2	1.3	2.6	-1.6	-0.2
Medication: Allopurinol	1.2	1.6	3.0	-1.7	-0.4
Breast cancer (self-reported)	1.2	1.5	2.1	1.4	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	4.5	2.1	0.8
Alzheimer’s Disease (in father)	1.1	1.2	1.8	-0.7	-1.3
Impedance of arm (left)	1.1	5.2	5.8	2.4	2.1
Exposure to tobacco smoke outside home	1.1	1.5	1.9	1.1	1.4
Back pain experienced in last month	1.1	1.6	3.1	-1.8	-0.0
Hearing aid user	1.1	1.2	1.3	1.1	1.1
Eye problems/disorders: Glaucoma	1.1	1.3	1.4	-1.1	-1.2
High cholesterol (Self-reported)	1.1	2.0	3.4	-0.8	-1.8
Blood Eosinophil Count	1.0	7.3	11.8	-3.4	-1.7
Waist Hip Ratio (WHR)	1.0	4.4	4.7	2.2	2.0
Townsend deprivation index at recruitment	1.0	1.4	2.6	1.6	0.3
Worrier / anxious feelings	1.0	1.8	3.4	1.8	0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	1.7	-0.7	-1.3
Suffer from ‘nerves’	1.0	1.6	3.0	-0.3	-1.7
Supplements: Calcium	1.0	1.1	1.7	0.7	1.3
Impedance of whole body	1.0	4.8	7.1	2.7	1.6
Verbal and Numeric Reasoning (VNR)	0.9	2.3	2.9	-1.3	-1.7
Medication: Ramipril	0.9	1.1	1.6	-1.3	-0.8
Peak expiratory flow (PEF)	0.9	2.1	3.6	1.9	0.7
Medication: Aspirin	0.9	1.2	2.0	-0.7	-1.4
Knee pain experienced in last month	0.9	1.4	2.6	-1.6	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	3.8	-2.0	-0.2
Illnesses of father: None of the above (group 1)	0.9	1.1	1.5	0.8	1.2
Intelligence (Savage-Jansen 2018)	0.8	2.4	4.1	-0.8	-2.0
Alzheimer’s Disease (in mother)	0.8	0.9	1.8	-1.4	0.1
Cardiovascular Disease	0.8	2.5	3.2	-1.8	-1.4
Impedance of leg (right)	0.8	4.0	7.3	2.7	0.8
High blood pressure (mother)	0.8	1.1	1.2	-1.1	-1.1
Alcohol usually taken with meals	0.8	1.3	1.3	-1.2	-1.1
Had menopause	0.8	0.9	1.6	-1.3	-0.5
Chronic bronchitis/emphysema (mother)	0.8	1.0	1.7	-1.3	-0.5
Overall health rating	0.8	1.7	2.8	0.8	1.7
Breast Cancer	0.7	1.7	2.5	-0.9	-1.6
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.3	-0.6	1.5
Chronotype (morning person)	0.7	1.7	3.1	-1.8	-0.6
Diabetes (self-reported)	0.7	1.0	1.0	-1.0	1.0
Impedance of arm (right)	0.7	3.2	4.4	2.1	1.4
Father’s age at death	0.7	1.0	2.0	1.4	0.1
Shortness of breath walking on level ground	0.7	0.9	1.7	-1.3	0.3
Mouth/teeth dental problems: Loose teeth	0.7	0.9	1.4	1.2	0.6
Number of self-reported non-cancer illnesses	0.7	1.2	2.4	-1.6	-0.0
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.3	-1.1	-0.6
Fractured/broken bones in last 5 years	0.7	1.0	1.2	-0.8	-1.1
Myopia	0.7	1.0	1.9	1.4	0.4
Lung FVC	0.6	2.9	5.8	2.4	0.1
Impedance of leg (left)	0.6	2.8	5.1	2.3	0.6
Qualifications: None of the above	0.6	1.3	1.8	-0.9	-1.3
Mouth/teeth dental problems: Dentures	0.6	1.0	1.9	-0.2	-1.4
Length of working week for main job	0.6	0.7	1.1	-0.5	1.0
Breastfed as a baby	0.6	0.7	1.3	-0.4	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	1.3	0.8	1.1
Number of full brothers	0.6	0.8	0.9	0.8	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.4	1.2	0.3
Medication for pain relief, constipation, heartburn	0.6	1.0	1.2	-1.1	-0.9
Neck or shoulder pain in last month	0.6	0.8	1.3	-1.1	-0.5
Hypertension (Self-reported)	0.6	1.7	2.3	-1.5	-1.0
Diabetes diagnosed by doctor	0.6	0.9	1.4	-0.7	1.2
Friendships satisfaction	0.6	0.7	1.3	1.2	-0.4
Unable to work because of sickness or disability	0.6	0.7	1.1	-1.1	-0.6
Fasting Glucose	0.5	0.6	1.3	1.1	0.0
Lung FEV1/FVC ratio	0.5	2.8	5.0	2.2	0.7
Ever had hysterectomy (womb removed)	0.5	0.6	0.6	0.7	0.8
Medication: Metformin	0.5	0.7	1.2	-0.5	1.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	0.9	0.9	0.5
Allergy	0.5	1.2	1.4	1.0	1.2
Time employed in main current job	0.5	0.6	0.7	-0.7	0.9
Pulse wave Arterial Stiffness index	0.5	0.6	0.7	-0.9	-0.7
Qualifications: College or University degree	0.5	1.5	1.8	1.3	1.1
Pulse rate, automated reading	0.5	1.7	3.4	0.2	1.9
Had major operations	0.5	0.5	0.8	-0.9	-0.5
Age at last live birth	0.5	0.7	1.1	1.0	0.5
Miserableness	0.5	0.9	1.5	-0.5	-1.2
Mother’s age at death	0.5	0.6	1.1	-0.4	-1.1
Ever smoked	0.5	0.9	1.0	-0.8	-1.0
Diastolic blood pressure, automated reading	0.5	1.6	2.1	-1.4	-1.0
Heart disease (siblings)	0.5	0.6	0.7	0.7	-0.9
Bipolar Disorder (2018)	0.4	0.6	1.2	1.1	0.0
Lupus	0.4	0.6	1.1	0.1	-1.1
Heel T-Score	0.4	3.1	4.5	2.1	1.3
Smoking Status	0.4	0.9	1.0	-1.0	-0.9
Neuroticism	0.4	1.1	1.1	1.0	1.1
Relative age voice broke	0.4	0.7	1.3	0.1	1.1
Age when periods started (menarche)	0.4	0.9	1.3	1.1	0.8
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.3	1.1	0.5
Number of incorrect matches in round	0.4	0.6	0.8	-0.9	-0.7
Financial difficulties in last 2 years	0.4	0.6	1.1	-1.1	-0.1
Pain all over the body in last month	0.4	0.4	0.4	-0.7	0.6
Fluid intelligence score	0.4	0.7	1.5	-1.2	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.2	-1.1	0.0
Falls in the last year	0.4	0.5	0.9	-0.9	0.4
Medication: Amlodipine	0.4	0.6	1.1	-0.1	-1.1
Age at first live birth	0.4	0.7	1.3	-0.2	-1.2
Medication: Blood pressure	0.4	0.6	1.1	-0.4	-1.1
Mean time to correctly identify matches	0.4	0.8	1.4	-0.5	-1.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.9	1.0	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.8	-0.3	-0.9
Eye problems/disorders: Cataract	0.4	0.4	0.8	0.9	0.3
Osteoporosis (self-reported)	0.4	0.5	0.5	-0.6	-0.7
Medication: Gliclazide	0.4	0.4	0.8	-0.9	0.2
Medication: Lisinopril	0.4	0.6	1.1	0.1	-1.1
Age started oral contraceptive pill	0.4	0.4	0.9	-0.0	-0.9
Alcohol drinker status: Previous	0.4	0.5	0.9	0.3	1.0
Pack years of smoking	0.4	0.6	1.1	-1.1	-0.3
Neuroticism (2016)	0.3	0.4	0.8	-0.3	-0.9
Blood White Count	0.3	2.0	3.1	-1.8	0.9
Hair Pigment	0.3	7.7	8.6	-2.9	-2.6
Average weekly spirits intake	0.3	0.4	0.7	0.3	0.8
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.8	-0.9	-0.2
Vitamin and mineral supplements	0.3	0.5	0.8	0.9	0.4
Chronic bronchitis/emphysema (father)	0.3	0.4	0.8	-0.9	0.1
Neuroticism score	0.3	0.6	0.7	0.9	0.6
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.5	1.2	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.6	-0.8	-0.4
Pulse wave peak to peak time	0.3	0.3	0.4	0.6	0.5
Illnesses of siblings: Diabetes	0.3	0.3	0.5	-0.7	0.4
Medication for cholesterol	0.3	0.5	0.5	0.7	0.6
Average weekly champagne plus white wine intake	0.3	0.5	0.5	-0.7	-0.6
Irritability	0.3	0.5	0.6	-0.8	-0.6
Depression (Nagel 2018)	0.2	0.4	0.4	0.6	0.6
Primary Biliary Cirrhosis	0.2	0.3	0.3	-0.6	0.4
Rheumatoid Arthritis	0.2	0.3	0.6	0.8	0.0
Blood Red Count	0.2	1.9	3.3	1.8	0.6
Systolic Blood Pressure	0.2	1.0	1.9	1.4	0.3
Allergy or Eczema	0.2	0.6	0.9	1.0	0.6
Tanning	0.2	2.4	2.7	-1.6	-1.4
Sensitivity / hurt feelings	0.2	0.3	0.4	-0.7	-0.3
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.4	0.6	-0.1
Severe depression (siblings)	0.2	0.2	0.3	-0.4	-0.6
Maternal smoking around birth	0.2	0.2	0.5	-0.1	0.7
Supplements: Glucosamine	0.2	0.2	0.3	-0.6	-0.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.2	0.5	0.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.5	0.7	0.3
Alcohol intake versus 10 years previously	0.2	0.4	0.5	0.5	-0.7
Happiness	0.2	0.2	0.3	0.6	0.3
Prospective memory result	0.2	0.2	0.3	0.3	-0.6
Illnesses of mother	0.2	0.2	0.4	0.6	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.2	1.1	0.3
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.4	-0.7	-0.4
Blood clot in the leg (DVT)	0.2	0.2	0.4	-0.3	0.6
Medication: Seretide 50 evohaler	0.2	0.2	0.3	-0.5	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.3	-0.5	-0.6
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.4	0.4	-0.6
Mood swings	0.2	0.3	0.4	-0.4	-0.6
Long-standing illness, disability or infirmity	0.2	0.3	0.4	-0.7	0.4
Financial situation satisfaction	0.2	0.2	0.5	0.1	0.7
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.2	0.5	0.4
Cholesterol lowering medication	0.2	0.3	0.4	0.5	0.6
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	0.7	0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.2	-0.4	0.4
Ovarian Cancer	0.1	0.1	0.2	-0.3	-0.4
Age at First Birth	0.1	0.2	0.4	-0.6	0.0
Triglycerides	0.1	0.2	0.5	-0.7	0.0
Ulcerative Colitis	0.1	0.1	0.2	0.4	0.0
Hearing difficulty/problems: Yes	0.1	0.1	0.2	-0.4	-0.0
Systolic blood pressure, automated reading	0.1	0.3	0.3	0.6	-0.5
Supplements: Zinc	0.1	0.2	0.2	-0.3	-0.5
Pack years adult smoking proportion	0.1	0.2	0.4	-0.6	-0.1
Current tobacco smoking	0.1	0.1	0.2	0.4	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	-0.3	-0.5
Qualifications: CSEs or equivalent	0.1	0.1	0.1	-0.3	0.3
Multivitamins +/- minerals	0.1	0.1	0.1	-0.4	-0.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	0.4	0.1
Had other major operations	0.1	0.1	0.1	-0.0	-0.4
Forced vital capacity (FVC)	0.1	0.5	1.0	0.3	-1.0
Mouth/teeth dental problems	0.1	0.2	0.3	-0.4	0.6
Medication: Simvastatin	0.1	0.2	0.2	-0.3	-0.4
Hair/balding pattern: Pattern 3	0.1	0.2	0.3	0.5	0.4
Forced vital capacity (FVC), Best measure	0.1	0.3	0.5	-0.3	-0.7
Health satisfaction	0.1	0.1	0.1	-0.3	0.3
Eye problems/disorders: None of the above	0.1	0.1	0.1	0.1	-0.4
Migraine (self-reported)	0.1	0.1	0.1	-0.4	-0.0
Medication: Omeprazole	0.1	0.1	0.1	-0.3	0.1
Alcohol intake frequency.	0.1	0.2	0.2	0.5	-0.5
Chest pain or discomfort	0.1	0.1	0.2	-0.4	-0.2
Family relationship satisfaction	0.1	0.2	0.2	0.5	0.4
Leg pain on walking	0.1	0.1	0.2	-0.5	-0.2
Loneliness, isolation	0.1	0.1	0.1	0.3	0.4
Ever had bowel cancer screening	0.1	0.1	0.1	0.3	0.3
Qualifications: nursing, teaching	0.1	0.2	0.3	-0.3	0.5
Guilty feelings	0.1	0.2	0.4	-0.1	0.6
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.3	-0.5	-0.4
Medication: Paracetamol	0.1	0.2	0.3	0.4	0.5
Alcohol drinker status: Never	0.1	0.1	0.1	-0.3	-0.2
Average weekly beer plus cider intake	0.1	0.1	0.2	-0.3	-0.4
Ever depressed for a whole week	0.1	0.2	0.3	-0.2	-0.5
Commuting to job workplace: Cycle	0.1	0.1	0.2	0.4	-0.1
Depressed Affect (Nagel 2018)	0.0	0.1	0.1	-0.3	-0.3
Neuroticism (Nagel 2018)	0.0	0.1	0.1	0.3	0.1
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2017)	0.0	0.0	0.0	-0.0	0.0
Irritable Bowel Disease (IBD)	0.0	0.0	0.0	-0.2	0.0
Ulcerative Colitis (UC)	0.0	0.0	0.1	-0.2	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.0	0.0	0.1	-0.1	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
HbA1C	0.0	0.1	0.1	-0.3	0.0
LDL Cholesterol	0.0	0.0	0.0	0.2	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0
Blood Platelet Count	0.0	0.4	0.5	-0.7	-0.5
Fed-up feelings	0.0	0.0	0.0	-0.1	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.0	0.1	-0.0
Pulse rate	0.0	0.0	0.0	-0.1	0.1
Noisy workplace	0.0	0.0	0.1	0.3	-0.0
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.1	-0.3	-0.2
Tense / ‘highly strung’	0.0	0.0	0.0	0.1	0.2
Pulse wave reflection index	0.0	0.0	0.0	-0.0	-0.0
Medication: Paracetamol	0.0	0.0	0.0	0.1	0.2
Headache pain in last month	0.0	0.1	0.1	0.2	0.3
Glaucoma (self-reported)	0.0	0.0	0.0	0.0	0.2
Worry too long after embarrassment	0.0	0.0	0.1	0.3	0.0
Heart disease (mother)	0.0	0.1	0.1	-0.3	-0.2
Illnesses of father: Heart disease	0.0	0.0	0.1	-0.1	-0.2
Mineral and other dietary supplements	0.0	0.0	0.1	0.0	0.2
Smoking status: Current	0.0	0.0	0.0	-0.0	-0.1
Medication: Blood pressure	0.0	0.1	0.1	-0.4	-0.1
Medication: Bendroflumethiazide	0.0	0.1	0.1	-0.3	0.2
Illnesses of father: High blood pressure	0.0	0.0	0.0	-0.2	0.1
Number of operations (self-reported)	0.0	0.1	0.1	0.1	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.1	-0.3	-0.1

Hub : Genes

PUF60

Models

Trait associations