Best TWAS P=4.71e-11 · Best GWAS P=1.11e-10 conditioned to 0.701
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | PPP6C | 0.06 | 0.10 | lasso | 3 | 0.07 | 3.2e-06 | 5.3 | -5.3 | 1.1e-07 | 0.74 | 0.88 | 0.11 | FALSE |
2 | GTEx | Adipose Subcutaneous | PSMB7 | 0.08 | 0.04 | lasso | 6 | 0.04 | 3.4e-04 | 4.7 | -5.9 | 4.3e-09 | 0.02 | 0.03 | 0.97 | FALSE |
3 | GTEx | Artery Aorta | PSMB7 | 0.15 | 0.03 | enet | 16 | 0.05 | 1.4e-03 | -4.3 | -5.2 | 1.8e-07 | 0.14 | 0.07 | 0.69 | FALSE |
4 | GTEx | Artery Tibial | GAPVD1 | 0.11 | 0.16 | enet | 19 | 0.16 | 6.4e-13 | -6.0 | -6.6 | 4.7e-11 | 0.94 | 0.02 | 0.98 | TRUE |
5 | GTEx | Artery Tibial | PRPS1P2 | 0.06 | 0.06 | enet | 6 | 0.05 | 9.2e-05 | 5.3 | 5.3 | 1.3e-07 | -0.65 | 0.82 | 0.15 | FALSE |
6 | GTEx | Brain Cerebellum | PRPS1P2 | 0.09 | 0.08 | enet | 16 | 0.04 | 2.8e-02 | -6.4 | 5.6 | 1.7e-08 | -0.84 | 0.05 | 0.79 | FALSE |
7 | GTEx | Breast Mammary Tissue | PSMB7 | 0.11 | 0.03 | lasso | 7 | 0.04 | 4.7e-03 | 6.1 | -6.0 | 2.3e-09 | 0.06 | 0.04 | 0.84 | TRUE |
8 | GTEx | Breast Mammary Tissue (Male) | PPP6C | 0.12 | 0.03 | enet | 12 | 0.03 | 6.5e-02 | 5.3 | -5.2 | 2.1e-07 | 0.64 | 0.07 | 0.10 | FALSE |
9 | GTEx | Breast Mammary Tissue (Female) | PPP6C | 0.14 | 0.04 | lasso | 4 | 0.04 | 3.1e-02 | 5.3 | -5.6 | 1.9e-08 | 0.74 | 0.08 | 0.80 | FALSE |
10 | GTEx | Cells Transformed fibroblasts | PRPS1P2 | 0.09 | 0.11 | enet | 8 | 0.13 | 9.6e-10 | 5.4 | 5.3 | 1.3e-07 | -0.65 | 0.88 | 0.12 | FALSE |
11 | GTEx | Colon Sigmoid | PSMB7 | 0.15 | 0.10 | lasso | 3 | 0.09 | 3.3e-04 | 5.7 | -5.9 | 3.8e-09 | 0.05 | 0.04 | 0.92 | FALSE |
12 | GTEx | Colon Transverse | PRPS1P2 | 0.11 | 0.10 | lasso | 1 | 0.08 | 1.8e-04 | 5.5 | 5.5 | 4.4e-08 | -0.68 | 0.60 | 0.11 | FALSE |
13 | GTEx | Esophagus Mucosa | PPP6C | 0.07 | 0.07 | enet | 21 | 0.08 | 7.1e-06 | 5.3 | -5.5 | 3.4e-08 | 0.67 | 0.89 | 0.10 | FALSE |
14 | GTEx | Esophagus Mucosa | PRPS1P2 | 0.07 | 0.08 | lasso | 3 | 0.07 | 1.5e-05 | 5.3 | 5.5 | 4.0e-08 | -0.67 | 0.49 | 0.43 | FALSE |
15 | GTEx | Esophagus Muscularis | OLFML2A | 0.08 | 0.00 | enet | 27 | 0.00 | 4.9e-01 | 5.1 | 5.8 | 7.3e-09 | -0.50 | 0.08 | 0.21 | FALSE |
16 | GTEx | Muscle Skeletal | PPP6C | 0.03 | 0.03 | enet | 6 | 0.01 | 3.0e-02 | 5.2 | -5.1 | 2.9e-07 | 0.68 | 0.47 | 0.16 | FALSE |
17 | GTEx | Muscle Skeletal | GAPVD1 | 0.13 | 0.10 | lasso | 3 | 0.09 | 4.7e-09 | -6.4 | 6.4 | 1.3e-10 | -0.95 | 0.02 | 0.98 | FALSE |
18 | GTEx | Nerve Tibial | NEK6 | 0.11 | 0.02 | enet | 40 | 0.03 | 3.9e-03 | 4.2 | -5.1 | 2.9e-07 | 0.07 | 0.07 | 0.52 | FALSE |
19 | GTEx | Nerve Tibial | GAPVD1 | 0.17 | 0.08 | lasso | 10 | 0.10 | 9.3e-08 | 5.3 | -6.4 | 1.5e-10 | 0.84 | 0.13 | 0.87 | FALSE |
20 | GTEx | Pancreas | PRPS1P2 | 0.16 | 0.13 | lasso | 6 | 0.12 | 8.7e-06 | 5.3 | 5.4 | 6.7e-08 | -0.67 | 0.81 | 0.16 | FALSE |
21 | GTEx | Skin Sun Exposed Lower leg | GAPVD1 | 0.04 | 0.01 | lasso | 4 | 0.01 | 3.8e-02 | 5.3 | -5.5 | 4.7e-08 | 0.77 | 0.21 | 0.68 | FALSE |
22 | GTEx | Thyroid | NEK6 | 0.20 | 0.21 | lasso | 4 | 0.20 | 1.3e-15 | 5.4 | -5.5 | 3.0e-08 | 0.05 | 0.45 | 0.55 | FALSE |
23 | GTEx | Thyroid | PSMB7 | 0.06 | 0.04 | lasso | 2 | 0.06 | 4.1e-05 | 4.3 | -5.3 | 1.4e-07 | 0.01 | 0.05 | 0.93 | FALSE |
24 | GTEx | Thyroid | GAPVD1 | 0.05 | 0.05 | enet | 13 | 0.01 | 6.6e-02 | -6.3 | -6.6 | 5.0e-11 | 0.96 | 0.02 | 0.98 | FALSE |
25 | GTEx | Thyroid | PRPS1P2 | 0.08 | 0.09 | enet | 18 | 0.07 | 4.0e-06 | 5.3 | 5.3 | 1.0e-07 | -0.72 | 0.86 | 0.14 | FALSE |
26 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PPP6C | 0.07 | 0.08 | lasso | 3 | 0.09 | 5.4e-10 | 5.3 | -5.3 | 1.5e-07 | 0.68 | 0.03 | 0.97 | FALSE |
27 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PPP6C | 0.02 | 0.02 | lasso | 2 | 0.01 | 1.5e-02 | 5.4 | -5.4 | 8.7e-08 | 0.68 | 0.02 | 0.70 | FALSE |
28 | The Cancer Genome Atlas | Lung Adenocarcinoma | PPP6C | 0.02 | 0.02 | lasso | 4 | 0.02 | 7.6e-04 | 5.3 | -5.3 | 1.1e-07 | 0.67 | 0.02 | 0.96 | FALSE |
29 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GAPVD1 | 0.02 | 0.04 | enet | 4 | 0.01 | 9.8e-03 | -6.5 | 6.4 | 1.2e-10 | -0.97 | 0.02 | 0.90 | FALSE |
30 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PPP6C | 0.06 | 0.08 | lasso | 7 | 0.07 | 1.8e-07 | 5.3 | -5.3 | 1.1e-07 | 0.64 | 0.02 | 0.98 | FALSE |
31 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PSMB7 | 0.03 | 0.04 | lasso | 4 | 0.04 | 1.2e-04 | 5.7 | -5.7 | 1.4e-08 | 0.03 | 0.04 | 0.92 | FALSE |
32 | The Cancer Genome Atlas | Thyroid Carcinoma | PPP6C | 0.08 | 0.13 | enet | 9 | 0.13 | 5.5e-13 | 5.3 | -5.3 | 1.2e-07 | 0.69 | 0.02 | 0.98 | FALSE |
33 | The Cancer Genome Atlas | Thyroid Carcinoma | PSMB7 | 0.06 | 0.06 | lasso | 4 | 0.04 | 3.7e-05 | 5.8 | -5.8 | 6.3e-09 | 0.07 | 0.10 | 0.90 | FALSE |