Best TWAS P=3.05e-09 · Best GWAS P=3.34e-09 conditioned to 0.0797
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PTPRJ | 0.05 | 0.05 | lasso | 2 | 0.04 | 3.9e-04 | 5.8 | 5.6 | 1.9e-08 | 0.59 | 0.01 | 0.97 | FALSE |
| 2 | GTEx | Artery Aorta | MADD | 0.09 | 0.03 | enet | 22 | 0.04 | 1.9e-03 | -3.9 | 5.2 | 1.5e-07 | 0.45 | 0.04 | 0.24 | FALSE |
| 3 | GTEx | Prostate | PSMC3 | 0.21 | 0.10 | lasso | 6 | 0.20 | 7.9e-06 | 4.4 | -5.4 | 6.3e-08 | -0.56 | 0.03 | 0.44 | FALSE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | LRP4 | 0.13 | 0.00 | lasso | 7 | 0.02 | 3.5e-02 | 4.2 | 5.1 | 3.0e-07 | 0.53 | 0.03 | 0.32 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | CELF1 | 0.03 | 0.01 | bslmm | 289 | 0.01 | 2.9e-02 | 4.8 | 5.9 | 3.1e-09 | 0.83 | 0.03 | 0.85 | TRUE |