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chr19:6,419,098-9,264,729

Best TWAS P=6.21e-14 · Best GWAS P=8.29e-15 conditioned to 1.78e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	MARCH2	0.30	0.30	lasso	6	0.31	5.9e-26	5.4	5.5	3.5e-08	0.01	0.01	0.98	FALSE
2	GTEx	Adipose Visceral Omentum	MARCH2	0.27	0.17	lasso	4	0.15	4.0e-08	5.3	5.5	4.7e-08	0.00	0.02	0.98	FALSE
3	GTEx	Artery Aorta	MARCH2	0.52	0.46	lasso	5	0.50	2.0e-31	5.4	5.4	8.5e-08	0.01	0.01	0.99	FALSE
4	GTEx	Artery Coronary	MARCH2	0.22	0.12	lasso	5	0.16	5.4e-06	5.1	5.2	2.6e-07	0.02	0.03	0.94	FALSE
5	GTEx	Artery Tibial	MARCH2	0.36	0.37	lasso	5	0.44	5.0e-37	4.3	5.3	1.4e-07	0.01	0.02	0.98	FALSE
6	GTEx	Brain Cerebellum	MARCH2	0.35	0.22	lasso	5	0.19	2.9e-06	5.4	5.4	5.8e-08	0.00	0.01	0.98	FALSE
7	GTEx	Brain Frontal Cortex BA9	MARCH2	0.48	0.13	lasso	10	0.14	1.2e-04	5.5	5.4	7.4e-08	-0.01	0.02	0.93	FALSE
8	GTEx	Brain Nucleus accumbens basal ganglia	MARCH2	0.30	0.21	lasso	5	0.28	3.9e-08	5.3	5.5	4.8e-08	0.01	0.02	0.97	FALSE
9	GTEx	Brain Putamen basal ganglia	MARCH2	0.52	0.25	lasso	10	0.37	9.0e-10	5.4	5.1	2.7e-07	0.01	0.02	0.96	FALSE
10	GTEx	Breast Mammary Tissue	MARCH2	0.24	0.13	lasso	7	0.11	4.6e-06	5.5	5.5	3.3e-08	0.00	0.01	0.99	FALSE
11	GTEx	Breast Mammary Tissue (Female)	MARCH2	0.26	0.14	lasso	6	0.11	3.3e-04	5.5	5.3	1.5e-07	0.00	0.02	0.95	FALSE
12	GTEx	Cells Transformed fibroblasts	MARCH2	0.35	0.27	enet	14	0.35	2.6e-27	5.4	5.3	1.1e-07	0.01	0.02	0.98	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	MARCH2	0.40	0.24	enet	52	0.25	1.2e-09	5.5	5.3	1.4e-07	0.03	0.01	0.99	FALSE
14	GTEx	Esophagus Mucosa	MARCH2	0.42	0.35	enet	14	0.36	3.1e-25	5.3	5.1	2.7e-07	0.00	0.02	0.98	FALSE
15	GTEx	Esophagus Muscularis	MARCH2	0.34	0.30	enet	22	0.32	6.9e-20	5.5	5.7	1.1e-08	0.02	0.01	0.99	FALSE
16	GTEx	Heart Left Ventricle	MARCH2	0.36	0.26	enet	21	0.28	3.3e-15	5.3	5.6	1.7e-08	0.01	0.01	0.99	FALSE
17	GTEx	Lung	MARCH2	0.36	0.25	lasso	8	0.29	2.8e-22	5.4	5.6	2.0e-08	0.00	0.01	0.99	FALSE
18	GTEx	Lung	EVI5L	0.17	0.10	lasso	7	0.12	7.9e-10	5.0	6.0	1.5e-09	0.04	0.03	0.97	TRUE
19	GTEx	Pancreas	MARCH2	0.19	0.09	lasso	3	0.08	2.8e-04	5.3	5.2	1.6e-07	0.01	0.02	0.94	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	MARCH2	0.42	0.33	enet	27	0.35	5.6e-20	5.3	6.0	1.6e-09	0.00	0.01	0.99	FALSE
21	GTEx	Skin Sun Exposed Lower leg	MARCH2	0.33	0.33	lasso	6	0.34	4.1e-29	5.4	5.4	8.2e-08	0.01	0.01	0.99	FALSE
22	GTEx	Stomach	MARCH2	0.33	0.05	enet	27	0.11	6.9e-06	4.3	5.2	2.1e-07	0.03	0.02	0.98	FALSE
23	GTEx	Testis	MARCH2	0.26	0.22	enet	12	0.22	6.8e-10	5.5	5.2	1.9e-07	-0.01	0.01	0.99	FALSE
24	NTR	Blood	MARCH2	0.05	0.06	lasso	4	0.06	1.0e-18	5.3	5.4	5.2e-08	0.02	0.02	0.98	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	PRAM1	0.04	0.00	enet	15	0.01	4.5e-02	4.0	-5.3	9.3e-08	-0.01	0.09	0.42	FALSE
26	ROSMAP	Brain Pre-frontal Cortex	INSR	0.15	0.09	bslmm	487	0.08	6.2e-11	-7.3	6.3	2.8e-10	-0.85	0.01	0.99	TRUE
27	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MARCH2	0.07	0.07	blup	42	0.08	1.4e-07	5.1	5.2	1.9e-07	0.03	0.01	0.99	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	MARCH2	0.06	0.06	lasso	3	0.06	7.5e-12	5.5	5.5	3.2e-08	0.00	0.00	1.00	FALSE
29	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MARCH2	0.08	0.06	lasso	5	0.06	5.5e-04	5.4	5.5	3.6e-08	0.00	0.00	0.98	FALSE
30	The Cancer Genome Atlas	Brain Lower Grade Glioma	MARCH2	0.10	0.10	enet	9	0.12	1.9e-13	5.1	5.2	1.7e-07	0.02	0.01	0.99	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	MYO1F	0.05	0.01	blup	42	0.03	2.2e-04	-4.8	-7.5	6.2e-14	0.05	0.02	0.56	TRUE
32	The Cancer Genome Atlas	Lung Adenocarcinoma	MARCH2	0.08	0.06	lasso	3	0.08	1.9e-09	5.5	5.2	1.8e-07	0.00	0.00	1.00	FALSE
33	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MARCH2	0.08	0.10	enet	5	0.10	2.6e-11	5.4	5.4	5.1e-08	-0.01	0.00	1.00	FALSE
34	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PRAM1	0.03	0.01	blup	44	0.01	7.3e-02	5.1	-5.3	1.3e-07	0.07	0.01	0.78	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	MARCH2	0.12	0.15	lasso	4	0.15	6.9e-16	5.4	5.5	2.9e-08	0.01	0.00	1.00	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	PRAM1	0.04	0.03	enet	10	0.04	1.3e-04	5.5	-5.1	2.9e-07	0.05	0.00	0.87	FALSE
37	The Cancer Genome Atlas	Stomach Adenocarcinoma	MARCH2	0.09	0.10	blup	42	0.10	6.1e-08	5.5	5.2	1.8e-07	0.03	0.00	1.00	FALSE
38	The Cancer Genome Atlas	Stomach Adenocarcinoma	PRAM1	0.05	0.02	blup	44	0.01	3.4e-02	-4.3	-5.4	7.7e-08	0.08	0.03	0.20	FALSE