TWAS hub - EVI5L

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.125	0.0390	1.1e-03	0.000	NA	-0.003	NA	0.001	3.0e-01	NA	9.9e-01	NA	2.8e-01
2	GTEx	Adipose Visceral Omentum	0.154	0.0540	2.3e-03	0.058	NA	0.092	NA	0.090	5.6e-04	NA	1.8e-05	NA	2.1e-05
3	GTEx	Artery Aorta	0.251	0.0870	3.0e-03	0.007	NA	0.008	NA	-0.004	1.2e-01	NA	1.1e-01	NA	6.8e-01
4	GTEx	Brain Cerebellum	0.268	0.0910	3.7e-03	-0.007	NA	-0.010	NA	0.000	5.8e-01	NA	9.6e-01	NA	3.1e-01
5	GTEx	Lung	0.169	0.0462	6.9e-05	0.097	NA	0.103	NA	0.125	7.2e-08	NA	2.7e-08	NA	7.9e-10
6	GTEx	Thyroid	0.110	0.0440	6.3e-03	0.112	NA	0.079	NA	0.095	6.7e-09	NA	1.1e-06	NA	1.1e-07
7	YFS	Blood	0.112	0.0220	5.8e-13	0.021	0.056	0.068	0.069	0.048	1.0e-07	7.1e-18	3.2e-21	1.2e-21	2.3e-15

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Diabetes (self-reported)	5.9	9.1	20.2	2.6	2.9	1.4	4.5	4.0	3.1	-0.8
Diabetes diagnosed by doctor	5.3	8.7	19.6	2.5	2.8	1.6	4.4	3.9	3.0	-0.7
Type 2 Diabetes (T2D) (2018)	4.9	9.2	15.6	3.4	2.3	1.8	4.0	3.9	3.1	-2.0
Medication: Metformin	4.7	6.6	12.4	2.8	2.6	2.0	3.5	3.2	2.2	0.4
Impedance of arm (right)	4.7	21.7	44.0	-3.2	-3.3	-4.4	-5.4	-6.6	-5.6	2.7
Impedance of arm (left)	4.3	19.9	40.2	-2.3	-3.4	-4.8	-5.0	-6.3	-5.3	2.5
Commuting to job workplace: Cycle	4.1	5.0	12.1	1.3	0.5	1.8	3.2	2.6	3.5	-0.8
Triglycerides	3.3	5.4	9.1	3.0	2.4	1.6	2.1	2.7	2.5	-1.4
HDL Cholesterol	3.2	5.4	8.9	-2.3	-1.5	-0.2	-2.9	-2.8	-3.0	2.1
Medication: Gliclazide	3.1	3.6	10.3	1.2	1.4	0.3	3.2	2.6	2.0	-0.0
Impedance of whole body	3.1	15.7	32.8	-1.1	-2.7	-4.2	-4.7	-5.7	-4.9	2.0
Trunk fat-free mass	2.8	16.0	40.3	1.2	2.5	4.1	4.5	6.3	5.0	-1.2
Trunk predicted mass	2.8	15.9	40.3	1.2	2.4	4.2	4.5	6.3	5.0	-1.2
Arm fat-free mass (right)	2.8	14.5	36.6	2.0	2.5	3.3	4.6	6.0	4.7	-0.7
Arm predicted mass (right)	2.8	14.3	36.6	1.9	2.4	3.3	4.6	6.0	4.7	-0.5
Arm fat-free mass (left)	2.7	13.6	34.5	1.5	2.6	3.5	4.5	5.9	4.4	-0.2
Eye problems/disorders: Diabetes related eye disease	2.6	2.8	8.0	0.2	1.4	-0.5	2.8	2.6	1.7	-0.1
Medication: Lisinopril	2.5	3.2	5.7	2.4	0.4	0.3	2.0	2.1	1.8	-2.2
Whole body fat-free mass	2.4	13.5	33.9	0.9	2.5	3.6	4.3	5.8	4.7	-0.6
Whole body water mass	2.4	13.6	34.4	1.0	2.5	3.5	4.4	5.9	4.7	-0.5
Fed-up feelings	2.3	4.2	12.2	1.2	-0.3	-0.4	-1.6	-2.6	-2.5	3.5
Arm predicted mass (left)	2.3	11.5	30.7	1.6	2.1	3.3	4.0	5.5	4.0	-0.3
Medication: Amlodipine	2.2	3.0	7.2	2.7	0.7	1.0	2.0	2.0	1.7	-1.4
High blood pressure (mother)	2.1	2.9	5.2	2.2	0.4	1.2	2.2	2.3	1.9	0.2
Number of children fathered	2.1	2.4	6.6	1.3	1.5	1.4	2.6	1.3	1.6	0.1
Handedness (chirality/laterality): Left-handed	2.1	2.5	9.3	-0.2	-1.7	-1.1	-0.6	-1.1	-1.6	3.0
Basal metabolic rate	2.1	11.6	28.7	1.2	2.6	3.2	4.1	5.4	4.2	-0.2
Nervous feelings	1.9	3.6	7.1	0.8	-1.0	-1.7	-2.7	-2.6	-2.5	0.6
Leg fat-free mass (right)	1.9	10.1	24.0	0.4	2.4	2.9	3.9	4.9	4.1	-0.2
Leg predicted mass (right)	1.9	10.0	23.9	0.4	2.3	2.9	3.9	4.9	4.1	-0.2
Severe depression (siblings)	1.8	2.0	4.3	-0.7	0.2	-1.1	-1.6	-2.0	-2.1	1.1
Maternal smoking around birth	1.8	2.6	7.3	-0.3	2.7	-0.1	2.3	1.3	1.8	-0.7
Leg predicted mass (left)	1.7	8.8	21.1	0.4	2.3	2.7	3.7	4.6	3.7	0.3
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.8	5.9	0.0	0.4	-2.4	-2.1	-1.3	-1.9	1.8
Medication: Ventolin 100micrograms inhaler	1.7	2.2	14.1	3.8	0.6	-0.3	0.7	0.3	0.4	-0.1
Medication for pain relief, constipation, heartburn	1.7	2.9	6.5	-2.5	-1.9	0.8	-1.4	-1.5	-1.5	1.7
Supplements: Vitamin C	1.7	2.0	5.3	0.9	-0.3	-2.3	-1.9	-1.2	-1.4	-1.1
Worry (Nagel 2018)	1.6	3.5	8.5	-0.1	-0.6	-1.6	-2.9	-2.6	-2.4	0.4
Neuroticism	1.6	4.0	8.8	-0.4	-0.0	-0.6	-3.0	-3.0	-2.7	1.5
Leg fat-free mass (left)	1.6	8.6	20.8	0.3	2.3	2.6	3.7	4.6	3.7	0.3
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	4.2	1.1	0.1	2.0	1.1	1.8	1.0	-1.7
Wears glasses or contact lenses	1.6	1.8	6.4	1.7	1.3	-0.8	2.5	0.3	1.1	0.2
Taking other prescription medications	1.5	2.3	5.5	2.3	1.1	-2.1	0.8	0.9	-0.3	1.8
Medication: Simvastatin	1.5	2.2	4.5	1.6	2.1	-0.7	1.7	0.7	1.1	-1.7
Eye problems/disorders: Glaucoma	1.5	1.7	4.9	1.2	1.8	-0.6	0.8	1.0	2.2	-0.8
Cardiovascular Disease	1.4	4.7	9.1	3.0	1.4	1.3	2.1	2.3	2.2	-2.3
Impedance of leg (right)	1.4	6.6	13.2	0.4	-1.4	-2.6	-3.3	-3.6	-3.4	1.1
Hand grip strength (right)	1.4	3.8	8.5	0.2	1.5	2.9	2.0	2.4	2.1	-1.3
Supplements: Glucosamine	1.4	1.8	4.7	0.3	-0.7	1.6	1.5	1.6	2.2	0.1
Ever taken oral contraceptive pill	1.4	1.6	3.4	1.8	1.0	0.2	1.0	1.4	1.6	-1.0
Tinnitus: Yes, now most or all of the time	1.4	1.7	3.2	-1.1	-1.3	1.4	-1.8	-1.3	-1.3	0.6
Ever had prostate specific antigen (PSA) test	1.4	1.6	4.8	1.2	2.2	0.9	1.2	1.0	0.9	-1.1
Cholesterol lowering medication	1.4	2.0	5.1	1.5	2.3	-0.6	1.1	1.3	1.3	-1.2
Average weekly fortified wine intake	1.3	1.5	3.3	1.3	0.4	-0.2	1.5	1.8	1.7	-0.0
Forced vital capacity (FVC)	1.3	5.1	9.1	1.3	2.2	1.1	2.0	3.0	3.0	-2.4
Heart attack	1.3	1.7	4.1	-0.2	-1.2	-2.0	-1.7	-0.9	-1.5	0.3
Lung cancer (father)	1.3	1.5	5.2	0.6	1.6	0.7	2.3	0.5	1.1	0.7
Birth weight of first child	1.3	2.4	5.0	1.7	1.1	1.1	1.5	2.0	2.2	-0.1
Ever highly irritable/argumentative for 2 days	1.3	1.6	5.6	0.9	1.3	2.4	0.0	1.4	0.7	-0.7
Medication for cholesterol	1.3	2.0	6.8	-2.6	-0.6	-0.8	-0.9	-1.5	-0.9	1.6
Heart attack/myocardial infarction (self-reported)	1.3	1.7	3.5	-0.1	-1.3	-1.9	-1.7	-1.0	-1.5	0.5
Neuroticism (2016)	1.2	1.7	6.4	2.1	0.1	-2.5	-0.6	-0.5	-0.7	-0.4
Sensitivity / hurt feelings	1.2	2.0	6.0	-0.2	0.1	-1.4	-2.5	-1.9	-1.5	-0.3
Age when periods started (menarche)	1.2	2.9	8.0	1.7	1.2	0.4	2.8	1.9	2.1	-0.1
Impedance of leg (left)	1.2	5.8	11.9	0.6	-1.5	-2.4	-3.2	-3.5	-3.2	0.5
Neuroticism score	1.2	2.6	5.7	0.6	0.5	-0.3	-2.1	-2.4	-2.0	1.7
Number of live births	1.2	1.7	5.9	1.6	2.4	-1.0	1.2	0.3	0.5	0.7
Medication: Cholesterol lowering	1.2	1.9	3.7	1.3	1.3	0.9	1.9	0.9	1.1	-1.9
Shortness of breath walking on level ground	1.2	1.5	3.0	0.9	-0.6	-1.7	-1.2	-1.1	-1.4	1.2
Leg pain on walking	1.2	1.6	4.1	-0.1	1.5	2.0	1.0	1.3	1.4	-0.4
Eye problems/disorders: Cataract	1.2	1.4	4.2	-1.3	-0.9	-1.1	-2.0	-1.2	-0.8	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	4.8	0.5	0.4	-0.4	0.4	1.6	1.5	-2.2
Osteoarthritis (self-reported)	1.2	1.5	5.6	1.5	-0.6	2.4	0.5	0.1	-0.2	1.5
Hearing aid user	1.2	1.4	3.0	-0.2	1.1	0.7	1.1	1.5	1.2	-1.7
Neuroticism (Nagel 2018)	1.1	2.6	5.8	0.7	-0.0	-0.7	-2.2	-2.1	-1.5	2.4
Supplements: Zinc	1.1	1.2	3.0	1.1	1.2	-0.5	0.3	1.0	1.0	-1.7
Diabetes (mother)	1.1	1.4	3.8	2.0	1.2	0.1	1.1	1.1	1.1	-1.0
Waist circumference	1.1	4.1	6.4	2.4	2.5	0.9	2.1	2.0	0.8	2.5
Alcohol usually taken with meals	1.1	1.8	5.5	-0.2	-0.4	-0.5	1.2	1.1	2.0	-2.4
Pain all over the body in last month	1.1	1.2	3.2	-0.5	-0.4	-1.4	-0.7	-1.8	-1.2	0.9
Weight	1.1	5.4	11.1	1.6	2.5	1.6	3.0	3.3	2.2	1.1
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.5	1.5	-0.3	0.4	-1.6	-1.4	-1.2	0.5
Comparative body size at age 10	1.1	3.1	5.7	-0.3	1.2	1.6	2.1	2.4	2.4	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	5.7	-0.0	0.1	0.8	1.5	1.2	0.4	2.4
Illnesses of siblings: Diabetes	1.1	1.3	3.7	0.9	0.4	0.5	1.6	1.9	1.1	0.6
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	4.6	0.8	-2.1	-1.1	-0.5	-0.6	-1.2	1.9
Guilty feelings	1.1	1.7	5.5	0.4	0.1	1.6	-1.3	-1.0	-1.0	2.4
Supplements: Fish oil (including cod liver oil)	1.1	1.4	4.6	0.0	-2.1	-0.6	-1.4	-1.1	-1.2	-0.0
High cholesterol (Self-reported)	1.1	2.0	3.3	1.6	1.8	1.0	1.8	1.0	1.2	-1.3
Irritability	1.1	1.9	4.8	0.4	-0.6	-1.2	-1.7	-1.3	-1.5	2.2
Ever had hysterectomy (womb removed)	1.0	1.1	2.9	-0.0	1.7	0.0	1.6	0.9	1.0	0.5
Angina	1.0	1.3	2.8	1.2	1.7	0.3	1.3	1.3	1.2	-0.2
Chronic bronchitis/emphysema (father)	1.0	1.2	4.4	2.1	0.1	0.8	1.0	0.6	1.2	-0.7
Financial difficulties in last 2 years	1.0	1.3	3.3	1.2	-0.0	0.6	-1.1	-0.4	-1.6	1.8
Happiness	1.0	1.2	2.2	-0.4	1.5	-1.4	-1.5	-0.7	-1.1	0.4
Number of full brothers	1.0	1.3	2.3	0.2	0.8	1.1	1.5	1.4	1.3	-1.2
Wheeze or whistling in the chest in last year	1.0	1.9	5.2	2.0	0.8	-1.0	1.4	0.5	-0.1	2.3
Had major operations	1.0	1.2	5.7	0.9	0.8	-2.4	-0.9	0.4	-0.1	-0.3
Average weekly red wine intake	1.0	1.4	5.8	-2.4	-1.1	-1.6	-0.7	0.3	-0.0	0.1
Long-standing illness, disability or infirmity	1.0	1.6	6.8	2.6	-0.2	-0.8	0.5	1.8	0.3	0.2
Breast cancer (self-reported)	1.0	1.2	2.3	-0.6	1.5	-1.5	-1.0	-1.2	-0.9	-0.2
Risk taking	1.0	1.4	2.7	-1.6	-1.3	-1.3	0.5	-0.4	-1.0	1.5
Depression (Nagel 2018)	0.9	1.4	2.6	-1.3	1.3	-0.6	-1.2	-0.8	-1.3	1.6
Ulcerative Colitis (UC)	0.9	1.8	6.8	-0.5	1.7	0.0	0.4	0.1	1.6	-2.6
Ulcerative Colitis	0.9	1.3	4.5	-2.1	1.8	0.2	0.3	-0.7	0.6	-0.7
Lung FEV1/FVC ratio	0.9	4.8	28.0	-5.3	0.3	-0.4	1.6	0.8	0.7	1.4
Number of treatments/medications taken	0.9	1.5	5.6	2.4	1.0	-1.8	-0.2	0.8	0.1	-0.2
Ever used hormone-replacement therapy (HRT)	0.9	1.2	5.5	2.3	0.6	-1.1	-0.3	0.3	-0.4	-1.0
Length of working week for main job	0.9	1.0	4.0	-0.7	-1.1	0.3	0.1	-0.9	-0.7	2.0
Tense / ‘highly strung’	0.9	1.6	4.9	-0.4	-0.4	-0.7	-2.2	-1.6	-1.6	-0.1
Forced vital capacity (FVC), Best measure	0.9	3.3	9.5	0.9	2.2	0.3	0.7	1.8	2.1	-3.1
Mouth/teeth dental problems: Loose teeth	0.9	1.0	2.5	0.8	-0.4	0.6	1.3	0.9	1.1	1.6
Medication: Allopurinol	0.9	1.2	3.5	1.9	1.1	1.4	0.7	0.8	0.5	-0.7
Medication: Omeprazole	0.9	1.1	3.0	-1.2	1.7	-0.8	-0.7	-0.5	-0.3	-1.3
Leg fat mass (right)	0.9	3.4	8.9	1.9	3.0	0.4	2.1	1.9	1.0	1.6
Medication: Aspirin	0.9	1.2	1.9	1.4	1.2	-0.3	1.2	1.0	0.8	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.4	0.5	0.2	-1.4	-1.2	-1.6	-1.0	-0.4
Mineral and other dietary supplements	0.9	1.2	4.1	0.2	2.0	0.4	1.5	0.9	1.0	0.0
Medication: Aspirin	0.9	1.2	3.1	1.8	1.0	-0.5	1.1	1.0	0.6	-1.0
Commuting to job workplace: Public transport	0.9	1.0	2.3	-0.6	0.3	-1.5	-0.8	-1.4	-1.4	-0.3
Myopia	0.9	1.4	3.1	1.8	-1.7	1.0	-0.5	-0.4	-1.0	-1.1
Leg fat mass (left)	0.9	3.4	8.4	1.9	2.9	0.4	2.1	1.9	1.1	1.4
Bipolar Disorder (2018)	0.8	1.3	3.9	0.3	0.9	0.0	-0.8	-1.7	-0.6	-2.0
BMI	0.8	4.8	10.2	0.8	3.2	0.3	2.9	2.8	2.4	-0.4
Average weekly spirits intake	0.8	1.0	2.6	1.1	0.1	-1.6	-0.8	-1.1	-1.2	-0.4
Relative age of first facial hair	0.8	1.7	4.9	-0.1	0.7	0.3	2.2	1.7	1.6	-0.8
Diabetes (father)	0.8	1.0	2.1	-0.9	0.6	0.4	1.3	1.4	1.5	0.0
Relative age voice broke	0.8	1.2	2.6	0.3	1.1	-1.1	1.4	1.2	1.6	-0.2
Medication: Atenolol	0.8	1.0	2.0	1.3	-0.8	-1.4	-0.9	-0.9	-1.1	-0.0
Hearing difficulty/problems with background noise	0.8	1.3	4.3	-0.4	-0.3	-0.3	-0.3	-2.1	-1.1	1.9
Asthma	0.8	1.6	6.8	2.6	1.2	0.2	0.9	1.1	0.7	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.1	1.3	0.9	0.2	1.4	1.4	1.3	-0.3
Pulse wave reflection index	0.8	1.0	3.1	0.7	1.8	-0.4	0.5	0.2	1.1	-1.4
Medication: Paracetamol	0.8	1.4	3.8	2.0	1.4	-0.6	0.4	0.6	1.1	-1.2
Glaucoma (self-reported)	0.8	0.9	3.0	0.5	1.3	-0.2	0.3	0.1	1.7	-1.1
Worry too long after embarrassment	0.8	1.3	3.7	0.8	0.6	1.2	-1.3	-1.9	-0.9	0.8
Alcohol intake frequency.	0.8	1.8	6.8	-0.9	1.3	-2.6	-1.2	0.1	-1.0	-0.7
Number of full sisters	0.8	0.9	3.5	0.9	-0.0	0.6	1.1	1.9	0.4	0.5
Overall health rating	0.8	1.8	5.0	1.1	-0.0	-2.2	-0.7	-0.5	-1.6	1.7
Chest pain or discomfort	0.8	1.2	3.2	-1.8	-0.0	-1.3	-0.1	-0.0	-0.9	1.6
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	2.8	-1.2	-1.2	-0.3	0.3	-0.9	-0.2	1.7
Mood swings	0.8	1.4	3.0	1.7	1.2	-1.4	-0.6	-0.6	-0.5	1.5
Loneliness, isolation	0.8	1.1	2.8	-1.3	-0.7	0.5	-0.8	-0.1	-1.3	1.7
Friendships satisfaction	0.8	0.9	2.1	-0.6	1.4	-1.1	-1.4	-0.1	-0.6	-0.8
Smoking status: Current	0.8	1.3	5.6	1.5	2.4	-0.0	0.6	0.7	0.3	-0.6
Mother’s age at death	0.8	1.0	3.1	-0.0	0.1	0.9	1.8	0.9	1.5	-0.1
Number of operations (self-reported)	0.8	1.1	2.7	1.6	1.1	-1.3	0.4	1.3	0.6	0.0
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	3.8	-0.8	1.9	-0.4	-0.4	-0.5	-0.2	-1.4
Alcohol drinker status: Previous	0.8	1.0	2.8	1.4	1.7	-0.5	-0.8	0.3	-0.6	-0.6
Depressed Affect (Nagel 2018)	0.7	1.5	7.4	0.5	0.0	-0.2	-0.8	-0.9	-1.1	2.7
Age at First Birth	0.7	1.0	2.5	-1.6	-0.6	-0.7	-1.5	-1.0	-0.6	0.1
Fasting Glucose	0.7	0.8	3.2	1.8	-0.5	-1.0	0.8	0.8	0.5	-0.2
Rheumatoid Arthritis	0.7	0.9	5.2	-0.6	2.3	-0.2	0.3	0.4	0.2	-0.7
Schizophrenia (2014)	0.7	1.5	3.8	-0.4	-0.6	-1.2	-1.9	-1.9	-1.0	-0.3
Allergy or Eczema	0.7	2.0	8.2	2.9	0.1	-0.2	2.0	0.3	0.8	0.9
Lung FVC	0.7	3.4	7.5	1.9	2.7	-1.0	1.0	1.3	1.5	-2.7
Frequency of depressed mood in last 2 weeks	0.7	0.9	2.0	-0.7	1.4	-1.0	-0.9	-0.8	-0.9	1.0
Medication: Co-codamol	0.7	0.8	1.3	1.0	1.1	0.9	1.2	1.1	-0.1	0.4
Current tobacco smoking	0.7	1.1	4.8	1.4	2.2	-0.4	0.4	0.6	0.2	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	4.9	0.0	2.2	-0.8	-0.2	0.4	-0.2	0.9
Had other major operations	0.7	0.8	2.6	1.4	-0.3	1.0	0.1	-0.1	-0.3	1.6
Allergy	0.7	1.6	5.1	-2.3	-0.3	-0.2	-1.2	-0.9	-0.4	-1.8
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.1	1.4	0.5	1.4	0.6	0.3	0.8	0.8
Medication: Ramipril	0.7	0.8	3.5	1.9	1.1	0.3	0.4	0.7	0.0	0.6
Falls in the last year	0.7	0.9	2.1	-1.1	-1.4	-1.1	-0.4	-0.0	-1.1	0.6
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	4.6	-0.4	1.4	0.8	1.5	2.1	2.2	-1.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	6.1	-0.4	1.6	0.5	0.8	1.6	1.8	-2.5
Loud music exposure frequency	0.7	0.8	1.6	-1.0	-1.1	-1.3	-0.7	-0.8	-0.6	0.5
Headache pain in last month	0.7	1.3	4.2	-0.1	-2.1	-0.8	-1.1	-0.4	-1.1	1.1
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	3.0	-1.7	-1.2	-0.4	-1.1	-0.6	-0.3	1.4
Birth weight	0.7	1.6	3.8	1.0	-0.6	-0.2	1.4	1.7	0.9	-2.0
Age at first live birth	0.7	1.2	3.8	-0.4	-2.0	0.0	-1.5	-0.9	-0.1	-1.1
Neck or shoulder pain in last month	0.7	1.0	3.8	-0.9	-0.4	-1.9	-0.9	-0.1	-1.0	0.7
Medication: Blood pressure	0.7	1.3	5.5	2.4	1.2	-0.2	0.8	0.6	0.3	-1.0
Angina (self-reported)	0.7	0.9	2.1	0.9	1.5	0.2	1.1	1.0	0.9	0.2
Migraine (self-reported)	0.7	0.8	3.3	-1.8	0.3	-1.0	0.0	-0.0	0.1	1.1
Medication: Seretide 50 evohaler	0.7	0.8	3.7	1.9	-0.3	-0.9	0.6	0.7	-0.0	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	1.8	0.7	-0.3	0.2	1.1	1.3	0.9	-1.2
Illnesses of father: Heart disease	0.7	1.0	2.4	-0.7	-0.6	-1.6	-0.9	-1.1	-0.7	-1.2
Osteoporosis (self-reported)	0.7	0.8	2.0	-0.0	0.6	-1.4	1.0	0.3	0.9	-1.3
Illnesses of father: None of the above (group 1)	0.7	0.8	2.2	-0.9	-1.5	0.2	-0.6	-0.8	-0.9	1.0
Average weekly champagne plus white wine intake	0.7	0.9	2.5	1.6	-0.7	-0.2	-0.5	-1.0	-1.4	0.4
Fractured/broken bones in last 5 years	0.7	0.9	1.7	0.5	1.3	0.3	1.0	1.1	1.1	-0.6
Reaction Time	0.6	1.2	2.5	-1.3	1.0	-1.6	-1.1	-1.1	-0.8	0.1
Crohns Disease (2012)	0.6	1.0	2.3	-0.3	-0.7	1.3	-1.5	-1.2	-0.7	0.7
Mean Putamen Volume	0.6	0.7	1.2	0.4	-0.8	1.0	-1.0	-0.8	-1.1	0.3
Lupus	0.6	0.8	1.6	1.1	-1.3	0.4	-0.7	-1.1	-1.1	-0.4
Blood Eosinophil Count	0.6	4.8	10.5	0.8	-0.9	3.1	3.2	2.3	2.6	0.1
Hand grip strength (left)	0.6	1.7	8.8	-0.5	1.2	3.0	0.6	0.4	0.7	0.0
Trunk fat percentage	0.6	2.5	9.4	1.0	1.7	-1.4	0.2	-0.9	-1.2	3.1
Townsend deprivation index at recruitment	0.6	0.8	2.0	0.9	0.8	-0.2	-0.3	-1.1	-1.4	0.9
Medication: Levothyroxine sodium	0.6	0.9	3.7	0.4	-0.2	-1.9	1.3	0.2	0.4	-0.8
Body mass index (BMI)	0.6	2.7	5.6	1.8	2.4	0.8	1.9	1.7	1.0	1.5
Hair/balding pattern: Pattern 2	0.6	0.7	3.0	1.2	-0.4	1.7	0.4	-0.2	-0.3	-0.3
Hip circumference	0.6	2.8	4.8	1.2	2.0	1.0	1.8	2.2	0.9	2.0
Depression (self-reported)	0.6	0.7	2.2	-1.4	0.2	0.7	-0.1	0.3	-0.2	1.5
Medication: Lansoprazole	0.6	0.7	2.8	1.7	1.1	-0.7	-0.1	0.4	-0.5	0.1
Illnesses of mother	0.6	0.7	2.2	-0.8	-0.7	0.3	-1.5	-1.0	-0.8	-0.1
Arm fat mass (right)	0.6	2.3	4.8	1.5	2.2	0.2	1.7	1.5	0.8	2.0
Standing height	0.6	5.5	15.1	-0.1	1.0	1.9	2.8	3.9	3.2	-0.8
Exposure to tobacco smoke at home	0.6	0.7	1.2	-1.1	1.1	-0.8	-1.0	0.0	-0.6	0.5
Peak expiratory flow (PEF)	0.6	1.5	3.0	-1.0	0.5	1.7	1.2	1.7	1.2	-0.7
High blood pressure (siblings)	0.6	0.9	1.9	0.3	0.6	-0.7	1.4	1.1	1.4	-0.7
Body fat percentage	0.6	2.3	7.2	1.4	1.9	-1.3	0.4	-0.6	-1.1	2.7
Leg fat percentage (right)	0.6	2.2	6.9	1.9	2.6	-0.5	0.7	0.3	-0.4	2.0
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.4	-0.7	0.4	-0.9	-0.5	-1.2	-1.0	0.7
Whole body fat mass	0.6	2.6	6.7	1.7	2.6	-0.1	1.7	1.2	0.6	2.0
Family relationship satisfaction	0.6	0.7	1.7	-1.3	0.0	-1.1	-1.2	0.2	-0.8	-0.4
Ever had bowel cancer screening	0.6	0.7	1.6	-0.0	1.3	0.9	1.1	0.8	0.5	0.8
Asthma (self-reported)	0.6	1.2	5.9	2.4	0.8	0.3	0.5	0.8	0.3	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	8.0	-0.4	0.9	0.3	-0.2	0.0	0.6	-2.8
Arm fat mass (left)	0.6	2.3	4.7	1.5	2.2	-0.1	1.7	1.6	0.7	1.9
Miserableness	0.6	1.1	3.6	1.2	1.9	0.7	0.5	0.5	0.3	1.3
Leg fat percentage (left)	0.6	2.1	6.7	2.0	2.6	-0.4	1.0	0.5	-0.2	1.6
Bipolar Disorder or Schizophrenia	0.5	1.1	3.6	-0.6	-0.6	-0.2	-1.2	-1.9	-0.9	-1.1
Intelligence (Savage-Jansen 2018)	0.5	1.4	3.7	1.0	-1.9	0.7	1.6	1.2	0.1	0.7
Schizophrenia (2018)	0.5	1.0	1.8	-1.0	-1.3	-1.4	-0.9	-1.1	-0.7	0.2
LDL Cholesterol	0.5	0.8	2.6	0.9	1.3	-0.1	-0.2	0.0	0.7	-1.6
Primary Biliary Cirrhosis	0.5	0.7	1.6	1.1	0.3	-0.5	-1.3	-0.9	-0.6	-0.5
Hypothyroidism (self reported)	0.5	1.1	3.6	-0.5	-1.1	-1.9	0.9	1.2	0.5	-0.2
Medication for hormone replacement therapy	0.5	0.6	1.5	1.2	-0.6	0.9	0.2	0.4	0.5	-0.8
Qualifications: CSEs or equivalent	0.5	0.6	2.2	0.2	-0.5	-1.5	-0.4	-0.8	-0.5	0.9
Serious illness, injury or assault to yourself	0.5	0.6	2.7	0.3	1.6	0.8	-0.2	0.1	-0.0	-0.8
High blood pressure	0.5	1.4	4.1	2.0	0.5	1.1	1.0	1.4	0.4	-0.9
Trunk fat mass	0.5	2.2	5.5	1.3	2.3	-0.2	1.5	0.8	0.3	2.3
Had menopause	0.5	0.7	2.2	-0.4	0.2	-1.5	1.4	0.4	0.2	-0.2
Fluid intelligence score	0.5	1.0	3.0	-1.0	-1.7	0.6	0.0	-0.4	-1.1	1.1
Illnesses of siblings	0.5	0.7	1.7	-0.9	-0.8	1.3	-1.0	-0.7	-0.4	0.1
Arm fat percentage (right)	0.5	1.9	8.4	0.8	1.2	-1.2	0.2	-0.6	-1.2	2.9
Worrier / anxious feelings	0.5	1.0	4.0	-0.0	0.4	-0.0	-1.3	-2.0	-1.0	-0.0
Hair/balding pattern: Pattern 3	0.5	0.8	1.4	-0.5	1.1	1.2	-0.2	1.0	0.6	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	3.0	1.7	0.6	0.4	0.4	-0.1	0.4	-0.9
Breastfed as a baby	0.5	0.6	3.1	0.5	-0.2	-0.2	0.1	0.6	0.7	-1.8
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	3.8	0.6	-0.8	-2.0	1.1	0.8	0.4	-0.4
Health satisfaction	0.5	0.7	1.8	1.0	1.1	-0.2	1.3	0.8	0.3	0.5
Emphysema/chronic bronchitis	0.5	0.6	1.4	0.8	-1.2	-0.5	0.5	0.5	-0.0	1.2
Medication: Ibuprofen	0.5	0.6	1.5	1.0	0.1	0.3	-1.2	-0.6	-0.5	-1.0
Heart disease (mother)	0.5	0.6	2.4	-0.5	-0.4	-0.1	1.6	0.9	0.8	-0.0
Pulse rate, automated reading	0.5	1.5	6.8	-0.8	0.3	-1.1	0.4	0.5	-1.2	2.6
Suffer from ‘nerves’	0.5	0.8	2.0	-0.8	-0.2	-0.4	-0.8	-1.4	-1.0	1.0
Knee pain experienced in last month	0.5	0.7	2.7	0.1	-0.5	1.6	-0.3	-0.3	-0.4	1.4
Hypertension (Self-reported)	0.5	1.4	6.7	2.6	0.1	0.7	0.5	1.1	0.1	-1.1
Arm fat percentage (left)	0.5	1.9	7.1	1.1	1.2	-1.4	0.2	-0.5	-1.1	2.7
Back pain experienced in last month	0.5	0.8	2.5	1.6	0.8	-0.6	-0.7	0.1	-0.1	-1.1
Number of self-reported non-cancer illnesses	0.5	0.8	3.0	1.7	-0.1	-0.5	0.9	0.9	0.1	0.8
Medication: Paracetamol	0.5	0.8	2.9	1.3	0.6	-0.6	-0.7	-0.1	0.3	-1.7
Ever smoked	0.5	0.9	2.8	0.9	0.6	-0.3	1.1	1.7	0.3	0.9
Heart disease (siblings)	0.5	0.6	1.4	1.1	1.0	-0.3	0.6	1.2	0.3	-0.4
Schizophrenia vs Biploar Disorder	0.4	0.5	2.1	-0.2	-0.9	0.0	-1.4	-0.6	-0.7	0.0
Alzheimer’s Disease (in mother)	0.4	0.4	1.5	-1.2	0.4	-0.6	0.0	-0.8	0.2	-0.5
Alzheimer’s Disease (in father)	0.4	0.4	1.0	1.0	-0.2	0.7	0.1	0.5	0.5	-0.8
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.9	-0.1	-1.2	1.2	0.5	-0.1	-0.9	1.4
Prostate Cancer	0.4	0.6	2.2	-0.7	-1.1	-1.5	-0.2	0.0	-0.3	-0.1
Body Mass Index (BMI) (2010)	0.4	0.6	0.8	0.9	0.7	0.8	0.6	0.9	0.7	-0.6
HbA1C	0.4	0.4	2.7	0.2	0.1	0.3	-0.2	-0.1	-0.4	-1.6
Heel T-Score	0.4	3.1	6.4	-2.0	-2.5	0.0	-2.0	-1.8	-2.0	0.3
Height	0.4	8.0	19.5	0.5	1.3	3.2	3.2	4.4	3.8	0.4
Vitamin and mineral supplements	0.4	0.5	2.1	-0.5	1.0	-0.1	1.5	0.2	0.5	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	4.5	0.0	-1.0	2.1	0.0	-0.5	-0.1	-0.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.6	0.4	0.8	-0.6	0.2	1.3	0.1	0.3
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.7	1.6	-0.5	0.3	1.1	0.2	0.2	1.4
Number of incorrect matches in round	0.4	0.6	1.3	-0.7	-1.1	0.1	-0.0	-1.0	-0.5	1.1
Past tobacco smoking	0.4	0.7	1.6	-1.0	-0.0	0.5	-0.8	-1.2	0.0	-1.2
Alcohol intake versus 10 years previously	0.4	0.6	1.6	-1.3	-1.2	-0.3	0.0	0.2	-0.9	0.7
Pulse rate	0.4	0.7	2.9	0.6	0.5	-1.7	0.9	0.2	0.2	0.5
Mouth/teeth dental problems: Dentures	0.4	0.7	2.2	-0.0	0.7	-1.5	0.9	1.3	0.3	0.2
Prospective memory result	0.4	0.5	1.8	0.1	0.5	-0.2	-0.9	-0.9	-1.3	0.4
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.7	-1.3	1.0	0.7	0.3	0.7	0.4	-0.2
Gout (self-reported)	0.4	0.6	1.3	0.4	1.1	0.9	0.9	0.8	0.5	0.3
Pulse wave peak to peak time	0.4	0.4	1.0	0.1	-1.0	0.8	0.3	0.9	0.6	-0.2
Mean time to correctly identify matches	0.4	0.8	2.0	-1.4	1.3	-1.0	-0.4	-0.5	-0.3	0.1
Age at last live birth	0.4	0.6	1.5	0.5	-1.0	-0.3	0.1	-0.3	1.0	-1.2
Smoking status: Previous	0.4	0.6	1.7	0.8	-0.7	-0.3	0.5	1.0	-0.1	1.3
Financial situation satisfaction	0.4	0.5	1.8	0.8	0.1	-1.3	-0.7	-0.1	-0.4	-0.8
Medication: Blood pressure	0.4	0.7	3.2	1.8	-1.0	0.5	0.1	0.5	-0.6	-0.1
Medication: Atorvastatin	0.4	0.5	1.5	0.4	-0.5	1.2	1.0	0.2	0.9	-0.4
Illnesses of father: High blood pressure	0.4	0.5	1.6	1.3	0.5	0.0	0.6	0.7	0.6	-0.4
Average weekly beer plus cider intake	0.4	0.5	2.0	1.4	-0.1	0.7	-0.1	-0.6	-0.5	0.7
Ever depressed for a whole week	0.4	0.5	2.0	-0.4	0.7	-0.5	-0.7	-1.4	-0.3	-0.5
Vascular/heart problems diagnosed by doctor	0.4	1.0	3.4	-1.9	-0.5	-0.8	-0.8	-1.1	-0.3	1.0
Supplements: Calcium	0.4	0.5	2.0	0.1	0.6	-0.1	-0.3	0.4	0.7	-1.4
Irritable Bowel Disease (IBD)	0.3	0.6	1.4	0.4	1.2	-0.6	0.0	-0.1	1.0	-1.2
Ovarian Cancer	0.3	0.4	1.6	1.3	0.4	-1.0	0.1	-0.2	-0.4	0.3
Smoking Status	0.3	0.7	1.4	1.2	1.2	0.2	0.3	0.5	-0.7	1.1
Respiratory disease	0.3	0.7	2.1	1.3	0.7	-0.6	-0.3	0.2	-0.1	1.4
Hearing difficulty/problems: Yes	0.3	0.5	1.1	0.9	0.6	1.1	0.9	-0.2	0.5	0.5
Sitting height	0.3	2.3	7.7	0.8	0.4	0.6	1.9	2.8	1.8	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.2	-0.6	0.7	-1.1	-0.5	0.2	-0.1	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	3.8	-0.4	-0.7	2.0	0.2	-0.4	0.0	0.0
Qualifications: None of the above	0.3	0.7	3.6	0.3	1.9	0.6	0.2	0.5	-0.3	0.7
Time employed in main current job	0.3	0.3	0.7	0.6	0.8	-0.6	-0.5	-0.1	-0.1	-0.7
Pulse wave Arterial Stiffness index	0.3	0.3	0.9	-0.1	0.9	-0.9	-0.2	-0.6	-0.5	0.2
Exposure to tobacco smoke outside home	0.3	0.4	1.1	0.4	-0.6	-1.0	0.1	-0.7	-0.6	-0.2
Eye problems/disorders: None of the above	0.3	0.4	1.4	0.5	-0.8	0.3	1.2	-0.0	-0.0	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.3	0.5	-0.6	0.3	-0.1	-0.0	0.8	1.1
Qualifications: nursing, teaching	0.3	0.4	1.4	-0.1	-0.4	0.3	0.6	0.9	0.4	1.2
Commuting to job workplace: Walk	0.3	0.3	0.8	0.6	0.9	0.4	0.0	-0.2	-0.0	0.9
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.0	0.8	1.0	-0.7	0.7	0.3	-0.1	-0.2
Medication: Bendroflumethiazide	0.3	0.5	1.9	0.8	0.8	1.4	0.1	0.6	0.0	0.2
Unable to work because of sickness or disability	0.3	0.3	1.5	1.2	-0.0	0.1	-0.4	-0.3	-0.7	0.1
Alzheimer’s Disease (including proxy)	0.2	0.3	1.0	-0.5	0.2	-0.0	0.1	-0.0	0.7	-1.0
Crohns Disease (2017)	0.2	0.5	0.9	0.8	-0.4	-0.4	-0.9	-0.9	-0.6	0.6
Breast Cancer	0.2	0.4	1.0	-0.3	-0.9	1.0	0.4	0.0	-0.0	-0.9
Blood Platelet Count	0.2	2.0	8.5	-1.0	0.3	-2.9	-1.1	-1.0	-1.5	0.1
Blood Red Count	0.2	2.0	8.6	1.2	0.7	-1.8	0.2	-0.3	0.3	-2.9
Blood White Count	0.2	1.6	5.5	1.3	0.3	-1.5	-0.4	-0.7	-0.9	-2.4
Waist Hip Ratio (WHR)	0.2	1.0	2.4	1.3	1.6	0.5	0.7	1.0	0.5	0.9
Chronotype (morning person)	0.2	0.5	3.3	0.3	0.6	-1.8	-0.1	0.1	-0.1	-0.2
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.3	0.2	1.1	-0.5	0.4	0.3	-0.4	-0.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	0.2	0.7	-0.5	-0.5	-0.5	-0.5	0.5
Multivitamins +/- minerals	0.2	0.2	0.6	0.3	-0.4	0.3	-0.4	0.7	0.8	0.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.6	-0.4	0.7	-0.4	-0.8	-0.4	-0.3	0.1
Father’s age at death	0.2	0.2	0.8	0.9	-0.5	-0.6	-0.4	0.1	-0.0	0.2
Noisy workplace	0.2	0.2	0.6	-0.2	0.8	-0.6	-0.1	-0.5	0.1	0.5
Hair/balding pattern: Pattern 4	0.2	0.5	1.8	0.7	-0.6	-1.4	-0.2	-0.7	-0.3	0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.7	-0.8	-0.5	-0.1	0.3	0.6	0.8	-0.8
Blood clot in the leg (DVT)	0.2	0.2	0.6	-0.7	-0.6	0.4	-0.1	0.3	0.1	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.7	1.3	0.1	-0.3	-0.9	0.3	-0.4	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	0.9	-0.3	0.1	-0.6	-0.4	-0.3	0.5
Age started oral contraceptive pill	0.2	0.3	1.1	-0.3	-0.7	-0.1	0.4	0.3	-0.4	1.1
Diastolic blood pressure, automated reading	0.2	0.6	1.4	1.1	0.6	1.2	0.5	0.7	0.7	0.4
Pain experienced in last month	0.2	0.3	1.4	0.4	-0.7	0.6	0.3	-0.1	0.0	-1.2
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	-0.5	0.2	0.5	0.7	0.5	-0.1	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.4	-0.6	-0.3	0.5	0.1	0.5	0.3	0.6
Pack years of smoking	0.2	0.2	0.8	-0.2	0.2	0.4	0.1	-0.4	-0.9	0.6
Type 2 Diabetes (T2D) (2012)	0.1	0.2	1.1	0.0	0.0	0.0	0.0	0.0	0.0	-1.0
Systolic Blood Pressure	0.1	0.4	1.3	1.2	-0.1	-0.0	-0.2	1.0	0.1	0.4
Systolic blood pressure, automated reading	0.1	0.4	1.2	0.7	0.6	0.1	0.6	1.1	0.4	0.1
Pack years adult smoking proportion	0.1	0.2	0.9	-0.1	0.2	0.2	0.1	-0.4	-0.9	0.6
Stomach or abdominal pain in last month	0.1	0.2	0.4	0.6	0.5	-0.4	0.1	0.6	0.2	0.1
Mouth/teeth dental problems	0.1	0.1	0.3	0.4	0.1	-0.1	-0.0	-0.6	0.3	-0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.2	1.2	-0.2	-1.1	-0.0	0.2	-0.1	0.4	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.5	-0.7	-0.2	-0.4	0.4	0.1	0.1	0.1
Qualifications: College or University degree	0.1	0.4	1.1	0.8	-0.7	-0.2	-1.0	-0.5	-0.1	-0.0
Comparative height size at age 10	0.1	0.5	1.7	-1.3	-0.2	0.2	-1.1	0.7	-0.4	0.1
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.4	-0.2	-0.5	-0.3	-0.4	0.6	0.1	0.4
Alcohol drinker status: Never	0.1	0.2	0.3	-0.3	0.4	-0.5	-0.1	-0.4	-0.5	-0.4
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	1.1	6.0	2.5	-0.0	-0.3	1.0	0.6	0.1	-0.3
Tanning	0.0	0.4	1.1	-1.1	1.0	-0.0	-0.3	-0.8	0.1	-0.4

Hub : Genes

EVI5L

Models

Trait associations