Best TWAS P=9.44e-12 · Best GWAS P=2.63e-09 conditioned to 0.0929
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | FIBP | 0.08 | 0.11 | enet | 20 | 0.12 | 8.1e-14 | 5.0 | 5.7 | 1.1e-08 | -0.34 | 0.24 | 0.76 | FALSE |
2 | GTEx | Adipose Subcutaneous | CTSW | 0.30 | 0.18 | lasso | 6 | 0.16 | 3.9e-13 | 5.0 | -5.3 | 1.1e-07 | 0.13 | 0.32 | 0.67 | FALSE |
3 | GTEx | Adipose Visceral Omentum | TRPT1 | 0.16 | 0.05 | lasso | 5 | 0.04 | 3.0e-03 | -4.8 | -5.7 | 9.3e-09 | 0.04 | 0.09 | 0.38 | FALSE |
4 | GTEx | Adrenal Gland | CTSW | 0.13 | 0.08 | lasso | 12 | 0.06 | 3.0e-03 | 5.6 | -6.0 | 2.3e-09 | 0.22 | 0.12 | 0.68 | FALSE |
5 | GTEx | Breast Mammary Tissue | CTSW | 0.25 | 0.19 | lasso | 8 | 0.16 | 1.3e-08 | 5.1 | -5.2 | 2.2e-07 | 0.13 | 0.32 | 0.68 | FALSE |
6 | GTEx | Breast Mammary Tissue (Male) | NEAT1 | 0.27 | 0.01 | enet | 29 | 0.03 | 6.3e-02 | 4.6 | 5.2 | 2.6e-07 | -0.16 | 0.03 | 0.34 | FALSE |
7 | GTEx | Cells EBV-transformed lymphocytes | CCS | 0.21 | 0.24 | enet | 11 | 0.21 | 2.0e-07 | -5.2 | 5.2 | 2.0e-07 | 0.04 | 0.18 | 0.81 | FALSE |
8 | GTEx | Cells Transformed fibroblasts | EFEMP2 | 0.06 | 0.06 | lasso | 3 | 0.07 | 7.8e-06 | 4.6 | 5.2 | 1.8e-07 | -0.23 | 0.10 | 0.88 | FALSE |
9 | GTEx | Colon Transverse | CTSW | 0.37 | 0.27 | lasso | 8 | 0.26 | 1.5e-12 | 5.0 | -5.3 | 9.8e-08 | 0.17 | 0.28 | 0.72 | FALSE |
10 | GTEx | Esophagus Mucosa | PLCB3 | 0.28 | 0.24 | lasso | 6 | 0.23 | 1.1e-15 | -5.9 | 5.4 | 7.9e-08 | -0.03 | 0.00 | 1.00 | FALSE |
11 | GTEx | Esophagus Muscularis | TRPT1 | 0.20 | 0.12 | enet | 18 | 0.15 | 2.3e-09 | -4.8 | -5.4 | 5.4e-08 | 0.04 | 0.19 | 0.81 | FALSE |
12 | GTEx | Esophagus Muscularis | CTD-3074O7.5 | 0.22 | 0.02 | enet | 17 | 0.09 | 3.7e-06 | -4.2 | 6.8 | 9.4e-12 | -0.50 | 0.29 | 0.47 | TRUE |
13 | GTEx | Heart Atrial Appendage | KLC2 | 0.10 | 0.04 | lasso | 8 | 0.09 | 1.1e-04 | 3.9 | -5.2 | 1.7e-07 | 0.56 | 0.30 | 0.36 | FALSE |
14 | GTEx | Heart Left Ventricle | FIBP | 0.12 | 0.09 | lasso | 3 | 0.07 | 9.8e-05 | 5.0 | 5.4 | 8.3e-08 | -0.17 | 0.27 | 0.69 | FALSE |
15 | GTEx | Liver | CTSW | 0.27 | 0.03 | lasso | 13 | 0.02 | 1.0e-01 | 5.0 | -5.2 | 1.5e-07 | 0.23 | 0.06 | 0.18 | FALSE |
16 | GTEx | Nerve Tibial | TRPT1 | 0.14 | 0.03 | lasso | 6 | 0.07 | 1.8e-05 | -5.0 | -5.3 | 1.4e-07 | 0.03 | 0.08 | 0.88 | FALSE |
17 | GTEx | Nerve Tibial | CTSW | 0.22 | 0.19 | lasso | 7 | 0.18 | 1.3e-12 | 5.0 | -5.2 | 2.2e-07 | 0.13 | 0.33 | 0.67 | FALSE |
18 | GTEx | Skin Not Sun Exposed Suprapubic | CTSW | 0.27 | 0.22 | lasso | 12 | 0.22 | 1.9e-12 | 5.1 | -5.5 | 3.4e-08 | 0.17 | 0.27 | 0.73 | FALSE |
19 | GTEx | Skin Sun Exposed Lower leg | CTSW | 0.19 | 0.19 | lasso | 6 | 0.18 | 1.1e-14 | 5.0 | -5.2 | 2.2e-07 | 0.13 | 0.33 | 0.67 | FALSE |
20 | GTEx | Thyroid | CTSW | 0.18 | 0.22 | lasso | 2 | 0.21 | 4.6e-16 | 5.0 | -5.2 | 1.5e-07 | 0.14 | 0.33 | 0.67 | FALSE |
21 | NTR | Blood | CCS | 0.03 | 0.04 | lasso | 2 | 0.04 | 1.2e-11 | -5.2 | 5.2 | 1.9e-07 | 0.03 | 0.19 | 0.81 | FALSE |
22 | ROSMAP | Brain Pre-frontal Cortex | CTSW | 0.06 | 0.03 | bslmm | 328 | 0.03 | 3.6e-05 | 5.3 | -5.6 | 1.8e-08 | 0.12 | 0.24 | 0.61 | FALSE |
23 | ROSMAP | Brain Pre-frontal Cortex | CCS | 0.08 | 0.04 | lasso | 9 | 0.06 | 8.9e-08 | -5.2 | 5.6 | 2.5e-08 | -0.05 | 0.21 | 0.79 | FALSE |
24 | ROSMAP | Brain Pre-frontal Cortex | CTSF | 0.07 | 0.08 | blup | 244 | 0.07 | 1.6e-09 | -4.2 | -5.3 | 1.5e-07 | 0.22 | 0.96 | 0.04 | FALSE |
25 | ROSMAP | Brain Pre-frontal Cortex | KCNK4 | 0.14 | 0.12 | bslmm | 334 | 0.11 | 3.0e-14 | -5.5 | -5.7 | 1.1e-08 | 0.06 | 0.00 | 1.00 | FALSE |
26 | ROSMAP | Brain Pre-frontal Cortex | TEX40 | 0.25 | 0.23 | lasso | 3 | 0.23 | 2.5e-29 | -5.9 | 5.8 | 6.0e-09 | -0.05 | 0.00 | 1.00 | FALSE |
27 | ROSMAP | Brain Pre-frontal Cortex | RP11-783K16.10 | 0.07 | 0.05 | lasso | 6 | 0.06 | 9.6e-08 | -5.9 | 5.7 | 1.3e-08 | -0.05 | 0.00 | 1.00 | FALSE |
28 | YFS | Blood | PRDX5 | 0.51 | 0.40 | lasso | 9 | 0.43 | 4.0e-157 | -5.5 | -5.4 | 5.6e-08 | 0.04 | 0.02 | 0.98 | FALSE |
29 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CTSW | 0.25 | 0.39 | blup | 44 | 0.41 | 7.3e-91 | 5.1 | -5.5 | 4.5e-08 | 0.17 | 0.05 | 0.95 | FALSE |
30 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SNX32 | 0.15 | 0.17 | blup | 60 | 0.17 | 2.9e-34 | 5.3 | 5.3 | 9.4e-08 | -0.16 | 0.02 | 0.98 | FALSE |
31 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | CTSW | 0.21 | 0.16 | blup | 44 | 0.17 | 7.5e-09 | 5.3 | -5.2 | 1.8e-07 | 0.10 | 0.04 | 0.96 | FALSE |
32 | The Cancer Genome Atlas | Colon Adenocarcinoma | CTSW | 0.40 | 0.34 | enet | 14 | 0.36 | 4.3e-22 | 5.0 | -5.1 | 2.9e-07 | 0.09 | 0.04 | 0.96 | FALSE |
33 | The Cancer Genome Atlas | Glioblastoma Multiforme | CTSW | 0.16 | 0.18 | enet | 16 | 0.19 | 2.3e-06 | 5.6 | -6.0 | 2.6e-09 | 0.23 | 0.01 | 0.98 | FALSE |
34 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C11orf20 | 0.06 | 0.03 | lasso | 3 | 0.02 | 7.2e-04 | -5.7 | 5.8 | 7.3e-09 | -0.04 | 0.00 | 0.98 | FALSE |
35 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CTSW | 0.31 | 0.32 | lasso | 4 | 0.34 | 1.8e-39 | 5.1 | -5.2 | 1.9e-07 | 0.13 | 0.05 | 0.95 | FALSE |
36 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C11orf20 | 0.07 | 0.07 | lasso | 4 | 0.07 | 6.4e-08 | -5.9 | 5.9 | 4.7e-09 | -0.05 | 0.00 | 1.00 | FALSE |
37 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CCDC87 | 0.03 | 0.02 | blup | 34 | 0.02 | 2.0e-03 | -4.9 | -5.6 | 1.7e-08 | 0.18 | 0.02 | 0.50 | FALSE |
38 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CTSW | 0.32 | 0.26 | lasso | 1 | 0.26 | 4.3e-15 | 5.3 | -5.3 | 1.2e-07 | 0.12 | 0.04 | 0.96 | FALSE |
39 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CTSF | 0.05 | 0.04 | blup | 35 | 0.04 | 1.2e-05 | -4.2 | -5.5 | 4.5e-08 | 0.13 | 0.18 | 0.72 | FALSE |
40 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CTSW | 0.13 | 0.14 | blup | 44 | 0.14 | 7.0e-16 | 5.1 | -5.3 | 1.2e-07 | 0.11 | 0.05 | 0.95 | FALSE |
41 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FIBP | 0.04 | 0.04 | lasso | 3 | 0.04 | 1.2e-05 | 5.3 | 5.2 | 1.9e-07 | -0.13 | 0.04 | 0.96 | FALSE |
42 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | CTSW | 0.63 | 0.41 | lasso | 8 | 0.42 | 1.2e-21 | 5.3 | -5.2 | 1.5e-07 | 0.12 | 0.04 | 0.96 | FALSE |
43 | The Cancer Genome Atlas | Lung Adenocarcinoma | CTSW | 0.23 | 0.29 | lasso | 7 | 0.29 | 1.0e-33 | 5.1 | -5.1 | 2.8e-07 | 0.13 | 0.04 | 0.95 | FALSE |
44 | The Cancer Genome Atlas | Lung Adenocarcinoma | SNX32 | 0.14 | 0.09 | blup | 60 | 0.13 | 8.8e-15 | 5.3 | 5.3 | 1.5e-07 | -0.16 | 0.04 | 0.96 | FALSE |
45 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C11orf20 | 0.04 | 0.03 | lasso | 2 | 0.03 | 4.2e-04 | -5.5 | 5.5 | 3.7e-08 | -0.05 | 0.00 | 0.99 | FALSE |
46 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CTSW | 0.25 | 0.34 | enet | 14 | 0.34 | 4.1e-40 | 5.1 | -5.3 | 1.4e-07 | 0.14 | 0.05 | 0.95 | FALSE |
47 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | CTSW | 0.20 | 0.23 | lasso | 9 | 0.23 | 1.5e-15 | 5.1 | -5.2 | 2.5e-07 | 0.13 | 0.05 | 0.95 | FALSE |
48 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | VEGFB | 0.04 | 0.04 | blup | 47 | 0.02 | 8.9e-03 | -4.9 | 6.0 | 2.0e-09 | -0.03 | 0.03 | 0.48 | TRUE |
49 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | CTSW | 0.30 | 0.23 | lasso | 11 | 0.24 | 1.7e-10 | 5.1 | -5.1 | 2.9e-07 | 0.14 | 0.05 | 0.95 | FALSE |
50 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | SNX32 | 0.30 | 0.19 | lasso | 1 | 0.14 | 3.9e-06 | 5.3 | 5.3 | 1.4e-07 | -0.12 | 0.03 | 0.96 | FALSE |
51 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C11orf20 | 0.07 | 0.03 | enet | 10 | 0.05 | 3.8e-06 | -5.9 | 5.3 | 1.4e-07 | 0.00 | 0.00 | 0.99 | FALSE |
52 | The Cancer Genome Atlas | Soft Tissue Sarcoma | SNX32 | 0.08 | 0.08 | lasso | 2 | 0.10 | 1.5e-06 | 4.6 | 5.4 | 5.5e-08 | -0.21 | 0.04 | 0.95 | FALSE |
53 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SNX32 | 0.12 | 0.13 | blup | 60 | 0.13 | 1.2e-09 | 5.1 | 6.3 | 3.8e-10 | -0.16 | 0.05 | 0.95 | TRUE |
54 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CTSW | 0.26 | 0.29 | lasso | 9 | 0.27 | 4.7e-10 | 5.1 | -5.4 | 8.3e-08 | 0.14 | 0.05 | 0.95 | FALSE |
55 | The Cancer Genome Atlas | Thyroid Carcinoma | PRDX5 | 0.05 | 0.04 | lasso | 3 | 0.02 | 1.6e-03 | -5.9 | 5.9 | 4.3e-09 | -0.05 | 0.00 | 0.95 | FALSE |
56 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | CTSW | 0.24 | 0.21 | enet | 21 | 0.24 | 2.9e-07 | 5.1 | -5.3 | 1.1e-07 | 0.17 | 0.05 | 0.95 | FALSE |