Best TWAS P=2.03e-18 · Best GWAS P=6.33e-19 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Colon Transverse | SSBP4 | 0.18 | 0.01 | enet | 21 | 0.00 | 3.6e-01 | 4.4 | -6.2 | 6.2e-10 | -0.25 | 0.07 | 0.08 | TRUE |
2 | GTEx | Colon Transverse | KIAA1683 | 0.15 | 0.02 | lasso | 3 | 0.02 | 3.3e-02 | -3.0 | 5.6 | 2.1e-08 | 0.15 | 0.37 | 0.06 | FALSE |
3 | GTEx | Pancreas | AC007192.6 | 0.19 | 0.00 | enet | 28 | 0.01 | 1.3e-01 | 7.9 | -5.3 | 1.2e-07 | -0.29 | 0.07 | 0.18 | FALSE |
4 | GTEx | Testis | PDE4C | 0.39 | 0.44 | lasso | 2 | 0.43 | 5.8e-21 | -6.2 | -6.2 | 5.4e-10 | -0.39 | 1.00 | 0.00 | FALSE |
5 | GTEx | Testis | AC068499.10 | 0.38 | 0.41 | lasso | 3 | 0.40 | 6.8e-19 | -6.2 | -6.3 | 2.7e-10 | -0.41 | 1.00 | 0.00 | TRUE |
6 | GTEx | Thyroid | KIAA1683 | 0.11 | 0.07 | enet | 14 | 0.12 | 2.1e-09 | 4.7 | 6.9 | 6.4e-12 | 0.23 | 0.96 | 0.02 | FALSE |
7 | GTEx | Vagina | LRRC25 | 0.63 | 0.02 | enet | 2 | 0.04 | 5.3e-02 | 7.2 | -7.2 | 7.8e-13 | -0.20 | 0.05 | 0.07 | FALSE |
8 | NTR | Blood | IFI30 | 0.03 | 0.02 | lasso | 6 | 0.02 | 8.8e-08 | 7.7 | 6.1 | 8.8e-10 | 0.31 | 0.90 | 0.08 | FALSE |
9 | ROSMAP | Brain Pre-frontal Cortex | JUND | 0.17 | 0.17 | lasso | 5 | 0.20 | 2.7e-25 | 7.2 | 5.8 | 4.9e-09 | 0.13 | 1.00 | 0.00 | FALSE |
10 | YFS | Blood | MAST3 | 0.06 | 0.04 | lasso | 5 | 0.04 | 4.2e-12 | 7.9 | -7.3 | 1.9e-13 | -0.56 | 0.86 | 0.14 | FALSE |
11 | The Cancer Genome Atlas | Glioblastoma Multiforme | JUND | 0.17 | 0.00 | blup | 57 | 0.03 | 5.4e-02 | 7.2 | 6.5 | 9.3e-11 | 0.25 | 0.01 | 0.59 | FALSE |
12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | JUND | 0.05 | 0.04 | lasso | 1 | 0.04 | 4.3e-05 | 7.2 | 7.2 | 6.4e-13 | 0.20 | 0.10 | 0.43 | FALSE |
13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MAST3 | 0.04 | 0.02 | blup | 65 | 0.01 | 7.3e-02 | 7.9 | -5.4 | 6.6e-08 | -0.53 | 0.01 | 0.13 | FALSE |
14 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | JUND | 0.11 | 0.03 | blup | 58 | 0.04 | 1.4e-03 | -3.8 | 6.9 | 6.2e-12 | 0.22 | 0.04 | 0.08 | TRUE |
15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | JUND | 0.04 | 0.03 | lasso | 2 | 0.02 | 7.9e-04 | 7.2 | 7.1 | 1.3e-12 | 0.19 | 0.12 | 0.39 | FALSE |
16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MAST3 | 0.02 | 0.02 | lasso | 3 | 0.01 | 1.5e-02 | 8.6 | -8.8 | 2.0e-18 | -0.95 | 0.01 | 0.95 | TRUE |
17 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IL12RB1 | 0.07 | 0.04 | blup | 58 | 0.06 | 4.9e-07 | 4.5 | -5.9 | 2.9e-09 | -0.57 | 0.88 | 0.10 | FALSE |
18 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CRTC1 | 0.33 | 0.08 | lasso | 5 | 0.12 | 3.6e-05 | -4.3 | -5.8 | 4.9e-09 | 0.04 | 0.04 | 0.52 | TRUE |
19 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | IL12RB1 | 0.10 | 0.01 | enet | 10 | 0.06 | 2.6e-03 | 1.1 | -6.1 | 1.2e-09 | -0.62 | 0.02 | 0.57 | FALSE |
20 | The Cancer Genome Atlas | Thyroid Carcinoma | MAST3 | 0.04 | 0.02 | lasso | 2 | 0.00 | 3.4e-01 | 8.6 | -8.7 | 5.0e-18 | -0.95 | 0.01 | 0.90 | FALSE |