Best TWAS P=5.16e-19 · Best GWAS P=4.15e-20 conditioned to 0.0284
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ANKRD31 | 0.10 | 0.13 | lasso | 9 | 0.13 | 3.9e-15 | -6.7 | 6.2 | 4.4e-10 | -0.33 | 1.00 | 0.00 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | POC5 | 0.17 | 0.16 | lasso | 5 | 0.15 | 5.2e-18 | -8.7 | 8.9 | 5.2e-19 | -0.90 | 0.05 | 0.95 | TRUE |
3 | GTEx | Adipose Subcutaneous | POC5 | 0.08 | 0.07 | lasso | 7 | 0.07 | 3.2e-06 | -5.7 | -5.8 | 5.0e-09 | 0.56 | 0.96 | 0.00 | FALSE |
4 | GTEx | Adipose Visceral Omentum | POC5 | 0.13 | 0.08 | lasso | 9 | 0.08 | 6.1e-05 | -5.8 | -5.8 | 5.2e-09 | 0.60 | 0.82 | 0.06 | FALSE |
5 | GTEx | Adrenal Gland | GCNT4 | 0.13 | 0.02 | lasso | 8 | 0.01 | 1.3e-01 | -6.3 | -7.8 | 7.5e-15 | 0.49 | 0.08 | 0.80 | TRUE |
6 | GTEx | Artery Tibial | GCNT4 | 0.08 | 0.07 | lasso | 2 | 0.04 | 3.9e-04 | -6.3 | 6.4 | 1.4e-10 | -0.44 | 0.55 | 0.26 | FALSE |
7 | GTEx | Brain Cerebellar Hemisphere | POLK | 0.27 | 0.20 | lasso | 6 | 0.16 | 8.3e-05 | -6.7 | -7.6 | 2.6e-14 | 0.64 | 0.30 | 0.26 | FALSE |
8 | GTEx | Brain Cerebellar Hemisphere | POC5 | 0.31 | 0.15 | enet | 18 | 0.30 | 1.6e-08 | -5.7 | -7.3 | 4.1e-13 | 0.61 | 0.45 | 0.43 | FALSE |
9 | GTEx | Brain Hypothalamus | CTC-366B18.4 | 0.26 | 0.12 | lasso | 8 | 0.07 | 9.0e-03 | -5.7 | 5.9 | 3.7e-09 | -0.56 | 0.10 | 0.09 | FALSE |
10 | GTEx | Cells EBV-transformed lymphocytes | POC5 | 0.47 | 0.36 | lasso | 4 | 0.39 | 1.3e-13 | -5.7 | -5.7 | 1.0e-08 | 0.57 | 1.00 | 0.00 | FALSE |
11 | GTEx | Cells Transformed fibroblasts | POLK | 0.06 | 0.04 | lasso | 3 | 0.04 | 1.0e-03 | -6.5 | 6.8 | 7.9e-12 | -0.61 | 0.19 | 0.59 | FALSE |
12 | GTEx | Cells Transformed fibroblasts | POC5 | 0.15 | 0.17 | lasso | 6 | 0.16 | 3.4e-12 | -5.8 | -5.8 | 8.0e-09 | 0.57 | 1.00 | 0.00 | FALSE |
13 | GTEx | Esophagus Mucosa | COL4A3BP | 0.09 | 0.06 | lasso | 5 | 0.05 | 4.2e-04 | -4.3 | 5.8 | 8.3e-09 | -0.51 | 0.55 | 0.34 | FALSE |
14 | GTEx | Esophagus Mucosa | POC5 | 0.18 | 0.16 | lasso | 1 | 0.15 | 4.8e-10 | -5.8 | -5.8 | 8.0e-09 | 0.57 | 1.00 | 0.00 | FALSE |
15 | GTEx | Nerve Tibial | POC5 | 0.16 | 0.12 | lasso | 5 | 0.10 | 7.6e-08 | -5.7 | -5.7 | 9.0e-09 | 0.57 | 0.99 | 0.00 | FALSE |
16 | GTEx | Pancreas | POC5 | 0.32 | 0.23 | lasso | 3 | 0.21 | 3.5e-09 | -5.8 | -5.8 | 5.2e-09 | 0.57 | 1.00 | 0.00 | FALSE |
17 | GTEx | Spleen | POLK | 0.18 | -0.01 | lasso | 16 | 0.03 | 5.1e-02 | -3.9 | -7.9 | 1.9e-15 | 0.59 | 0.15 | 0.28 | FALSE |
18 | GTEx | Spleen | POC5 | 0.42 | 0.37 | lasso | 4 | 0.34 | 1.3e-09 | -5.7 | -5.9 | 4.0e-09 | 0.57 | 0.89 | 0.08 | FALSE |
19 | GTEx | Spleen | CTC-366B18.2 | 0.16 | 0.11 | lasso | 3 | 0.14 | 2.2e-04 | -5.7 | -7.3 | 2.1e-13 | 0.72 | 0.08 | 0.69 | FALSE |
20 | GTEx | Testis | POC5 | 0.27 | 0.13 | lasso | 8 | 0.09 | 8.1e-05 | -6.4 | 6.2 | 7.6e-10 | -0.65 | 0.40 | 0.46 | FALSE |
21 | GTEx | Testis | GCNT4 | 0.42 | 0.35 | enet | 62 | 0.37 | 3.8e-17 | -6.5 | -7.6 | 3.3e-14 | 0.50 | 0.89 | 0.11 | FALSE |
22 | GTEx | Thyroid | CTC-366B18.2 | 0.06 | 0.03 | lasso | 9 | 0.02 | 6.2e-03 | -7.1 | -7.1 | 1.5e-12 | 0.62 | 0.23 | 0.36 | FALSE |
23 | METSIM | Adipose | POLK | 0.05 | 0.01 | enet | 16 | 0.03 | 4.3e-05 | -7.5 | -8.5 | 1.4e-17 | 0.58 | 0.68 | 0.31 | FALSE |
24 | ROSMAP | Brain Pre-frontal Cortex | POLK | 0.03 | 0.01 | lasso | 7 | 0.02 | 3.9e-03 | -7.2 | -8.4 | 3.9e-17 | 0.81 | 0.27 | 0.63 | FALSE |
25 | ROSMAP | Brain Pre-frontal Cortex | POC5 | 0.05 | 0.00 | blup | 384 | 0.02 | 8.6e-04 | -5.7 | -5.8 | 6.8e-09 | 0.57 | 0.27 | 0.21 | FALSE |
26 | ROSMAP | Brain Pre-frontal Cortex | ANKDD1B | 0.07 | 0.00 | bslmm | 382 | 0.03 | 7.0e-05 | -5.7 | 7.4 | 1.2e-13 | -0.63 | 0.07 | 0.60 | FALSE |
27 | The Cancer Genome Atlas | Colon Adenocarcinoma | GCNT4 | 0.10 | 0.06 | enet | 6 | 0.05 | 8.7e-04 | -3.1 | 5.6 | 1.7e-08 | -0.41 | 0.07 | 0.57 | FALSE |
28 | The Cancer Genome Atlas | Brain Lower Grade Glioma | POC5 | 0.04 | 0.00 | enet | 7 | 0.03 | 2.1e-04 | -8.7 | 7.1 | 1.3e-12 | -0.77 | 0.02 | 0.62 | FALSE |
29 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | HMGCR | 0.04 | 0.02 | enet | 4 | 0.03 | 6.0e-03 | -6.6 | -6.6 | 3.7e-11 | 0.57 | 0.02 | 0.63 | FALSE |
30 | The Cancer Genome Atlas | Prostate Adenocarcinoma | POLK | 0.03 | 0.01 | blup | 53 | 0.01 | 1.6e-02 | -4.8 | 6.5 | 6.3e-11 | -0.57 | 0.26 | 0.52 | FALSE |
31 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | POC5 | 0.24 | 0.13 | blup | 70 | 0.14 | 1.2e-04 | -6.7 | -6.3 | 2.8e-10 | 0.73 | 0.06 | 0.76 | FALSE |