Best TWAS P=5.38e-09 · Best GWAS P=6.67e-09 conditioned to 0.619
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HR | 0.06 | 0.01 | bslmm | 452 | 0.03 | 3.8e-05 | -3.1 | 5.4 | 7.0e-08 | 0.51 | 0.05 | 0.84 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | NUDT18 | 0.10 | 0.07 | enet | 10 | 0.07 | 2.3e-06 | 5.7 | 5.2 | 1.6e-07 | 0.87 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | SLC25A37 | 0.13 | 0.05 | lasso | 5 | 0.04 | 3.0e-04 | -5.8 | 5.3 | 1.1e-07 | 0.02 | 0.00 | 1.00 | TRUE |
| 4 | GTEx | Cells Transformed fibroblasts | FAM160B2 | 0.18 | 0.09 | lasso | 5 | 0.10 | 4.0e-08 | -5.5 | 5.2 | 2.0e-07 | 0.68 | 0.04 | 0.96 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | NUDT18 | 0.10 | 0.04 | enet | 6 | 0.03 | 4.7e-03 | 5.2 | 5.8 | 8.5e-09 | 0.89 | 0.01 | 0.94 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | AC091171.1 | 0.15 | 0.06 | lasso | 2 | 0.05 | 2.2e-04 | -5.5 | 5.4 | 5.8e-08 | 0.69 | 0.05 | 0.92 | FALSE |
| 7 | GTEx | Esophagus Mucosa | FAM160B2 | 0.15 | 0.05 | enet | 19 | 0.09 | 1.7e-06 | 5.6 | 5.2 | 1.9e-07 | 0.77 | 0.01 | 0.99 | FALSE |
| 8 | GTEx | Esophagus Mucosa | AC091171.1 | 0.14 | 0.07 | lasso | 4 | 0.05 | 2.2e-04 | 5.7 | 5.8 | 5.4e-09 | 0.94 | 0.01 | 0.99 | TRUE |
| 9 | GTEx | Skin Not Sun Exposed Suprapubic | NUDT18 | 0.31 | 0.15 | enet | 13 | 0.22 | 4.6e-12 | -4.9 | -5.2 | 1.7e-07 | -0.71 | 0.25 | 0.75 | FALSE |
| 10 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | NUDT18 | 0.09 | 0.03 | blup | 45 | 0.08 | 1.3e-04 | -5.1 | -5.5 | 3.2e-08 | -0.78 | 0.05 | 0.92 | FALSE |
| 11 | The Cancer Genome Atlas | Colon Adenocarcinoma | FAM160B2 | 0.06 | 0.07 | lasso | 1 | 0.06 | 2.3e-04 | 5.6 | 5.6 | 2.6e-08 | 0.93 | 0.01 | 0.93 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LOXL2 | 0.16 | 0.03 | lasso | 4 | 0.05 | 1.2e-03 | -4.3 | 5.1 | 2.7e-07 | 0.10 | 0.01 | 0.38 | FALSE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NUDT18 | 0.11 | 0.22 | lasso | 6 | 0.22 | 3.6e-24 | -5.5 | -5.5 | 3.6e-08 | -0.78 | 0.06 | 0.94 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FAM160B2 | 0.05 | 0.01 | enet | 11 | 0.03 | 1.7e-04 | -5.3 | 5.3 | 8.8e-08 | 0.70 | 0.03 | 0.94 | FALSE |
| 15 | The Cancer Genome Atlas | Thyroid Carcinoma | FAM160B2 | 0.08 | 0.06 | lasso | 4 | 0.05 | 1.4e-05 | -5.5 | 5.4 | 8.8e-08 | 0.64 | 0.04 | 0.95 | FALSE |
| 16 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | NUDT18 | 0.15 | 0.17 | lasso | 4 | 0.12 | 2.3e-04 | -5.3 | -5.6 | 1.9e-08 | -0.78 | 0.02 | 0.95 | FALSE |