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chr19:17,512,412-19,190,906

Best TWAS P=2.92e-16 · Best GWAS P=4.9e-17 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
12	The Cancer Genome Atlas	Brain Lower Grade Glioma	MAST3	0.02	0.02	lasso	3	0.01	1.5e-02	8.1	-8.2	2.9e-16	-0.95	0.01	0.94	TRUE
2	GTEx	Testis	AC068499.10	0.38	0.41	lasso	3	0.40	6.8e-19	-5.9	-6.0	2.3e-09	-0.41	1.00	0.00	TRUE
10	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	JUND	0.11	0.03	blup	58	0.04	1.4e-03	-3.9	5.9	3.1e-09	0.22	0.04	0.08	TRUE
14	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CRTC1	0.33	0.08	lasso	5	0.12	3.6e-05	-3.5	-5.6	2.2e-08	0.04	0.04	0.52	TRUE
16	The Cancer Genome Atlas	Thyroid Carcinoma	MAST3	0.04	0.02	lasso	2	0.00	3.4e-01	8.1	-8.1	5.7e-16	-0.95	0.01	0.88	FALSE
6	YFS	Blood	MAST3	0.06	0.04	lasso	5	0.04	4.2e-12	7.1	-6.8	1.3e-11	-0.56	0.93	0.07	FALSE
15	The Cancer Genome Atlas	Testicular Germ Cell Tumors	IL12RB1	0.10	0.01	enet	10	0.06	2.6e-03	1.3	-6.3	3.6e-10	-0.62	0.02	0.55	FALSE
1	GTEx	Testis	PDE4C	0.39	0.44	lasso	2	0.43	5.8e-21	-5.9	-5.9	4.4e-09	-0.39	1.00	0.00	FALSE
3	GTEx	Thyroid	KIAA1683	0.11	0.07	enet	14	0.12	2.1e-09	3.2	5.7	1.6e-08	0.23	0.97	0.01	FALSE
9	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAST3	0.04	0.02	blup	65	0.01	7.3e-02	7.1	-5.6	2.2e-08	-0.53	0.01	0.14	FALSE
7	The Cancer Genome Atlas	Glioblastoma Multiforme	JUND	0.17	0.00	blup	57	0.03	5.4e-02	5.4	5.6	2.4e-08	0.25	0.01	0.59	FALSE
8	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	JUND	0.05	0.04	lasso	1	0.04	4.3e-05	5.4	5.4	6.2e-08	0.20	0.14	0.13	FALSE
4	GTEx	Vagina	LRRC25	0.63	0.02	enet	2	0.04	5.3e-02	5.4	-5.4	7.1e-08	-0.20	0.05	0.06	FALSE
13	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IL12RB1	0.07	0.04	blup	58	0.06	4.9e-07	4.5	-5.4	7.7e-08	-0.57	0.88	0.10	FALSE
11	The Cancer Genome Atlas	Brain Lower Grade Glioma	JUND	0.04	0.03	lasso	2	0.02	7.9e-04	5.4	5.3	1.1e-07	0.19	0.19	0.04	FALSE
5	NTR	Blood	IFI30	0.03	0.02	lasso	6	0.02	8.8e-08	6.9	5.3	1.3e-07	0.31	0.94	0.05	FALSE