Best TWAS P=2.13e-11 · Best GWAS P=3.15e-13 conditioned to 9.79e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CRELD1 | 0.46 | 0.16 | enet | 51 | 0.27 | 2.2e-22 | -5.6 | -5.6 | 2.3e-08 | 0.07 | 0.03 | 0.97 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | CRELD1 | 0.19 | 0.12 | lasso | 4 | 0.10 | 4.1e-06 | -5.6 | -5.3 | 1.4e-07 | -0.02 | 0.04 | 0.88 | FALSE |
| 3 | GTEx | Artery Aorta | CRELD1 | 0.30 | 0.07 | lasso | 7 | 0.12 | 2.4e-07 | -5.6 | -5.2 | 1.6e-07 | 0.03 | 0.04 | 0.96 | FALSE |
| 4 | GTEx | Artery Aorta | AC034193.5 | 0.12 | 0.01 | lasso | 3 | 0.00 | 1.6e-01 | 5.1 | 5.1 | 2.7e-07 | -0.01 | 0.14 | 0.48 | FALSE |
| 5 | GTEx | Artery Aorta | RP11-1020A11.1 | 0.15 | 0.01 | lasso | 3 | 0.00 | 4.0e-01 | -5.6 | -6.3 | 3.8e-10 | -0.03 | 0.03 | 0.54 | FALSE |
| 6 | GTEx | Breast Mammary Tissue | CRELD1 | 0.25 | 0.19 | lasso | 6 | 0.18 | 2.2e-09 | -5.6 | -5.3 | 9.1e-08 | -0.02 | 0.03 | 0.97 | FALSE |
| 7 | GTEx | Cells EBV-transformed lymphocytes | CYCSP10 | 0.19 | 0.01 | lasso | 5 | -0.01 | 6.6e-01 | 5.0 | -5.2 | 2.5e-07 | 0.01 | 0.07 | 0.19 | FALSE |
| 8 | GTEx | Cells Transformed fibroblasts | CRELD1 | 0.39 | 0.19 | enet | 39 | 0.28 | 4.5e-21 | -5.6 | -6.2 | 4.5e-10 | 0.04 | 0.03 | 0.97 | FALSE |
| 9 | GTEx | Cells Transformed fibroblasts | HRH1 | 0.20 | 0.00 | lasso | 3 | 0.01 | 1.1e-01 | 7.3 | -6.2 | 4.2e-10 | -0.77 | 0.00 | 0.95 | TRUE |
| 10 | GTEx | Cells Transformed fibroblasts | RP11-1020A11.1 | 0.20 | 0.10 | enet | 67 | 0.09 | 1.9e-07 | -5.6 | -5.6 | 2.3e-08 | 0.01 | 0.03 | 0.96 | FALSE |
| 11 | GTEx | Esophagus Muscularis | CRELD1 | 0.21 | 0.10 | lasso | 1 | 0.08 | 1.7e-05 | -5.6 | -5.6 | 2.6e-08 | -0.02 | 0.03 | 0.93 | FALSE |
| 12 | GTEx | Skin Not Sun Exposed Suprapubic | AC034193.5 | 0.15 | 0.09 | enet | 11 | 0.08 | 3.3e-05 | 5.1 | 5.2 | 1.9e-07 | 0.02 | 0.29 | 0.63 | FALSE |
| 13 | GTEx | Testis | CRELD1 | 0.22 | 0.22 | lasso | 8 | 0.26 | 1.1e-11 | 5.1 | -6.7 | 2.1e-11 | 0.00 | 0.13 | 0.87 | TRUE |
| 14 | GTEx | Thyroid | CIDECP | 0.11 | 0.12 | lasso | 2 | 0.11 | 1.1e-08 | 5.1 | 5.1 | 2.9e-07 | 0.00 | 0.27 | 0.73 | FALSE |
| 15 | GTEx | Thyroid | BRK1 | 0.08 | 0.05 | lasso | 3 | 0.04 | 6.8e-04 | 5.0 | -5.3 | 8.6e-08 | 0.01 | 0.23 | 0.76 | FALSE |
| 16 | METSIM | Adipose | BRK1 | 0.04 | 0.02 | bslmm | 559 | 0.01 | 8.9e-03 | 5.0 | -5.6 | 2.5e-08 | -0.04 | 0.14 | 0.71 | FALSE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | AC022007.5 | 0.05 | 0.02 | blup | 515 | 0.03 | 2.8e-04 | 5.5 | 5.5 | 4.2e-08 | 0.02 | 0.04 | 0.96 | FALSE |
| 18 | YFS | Blood | FANCD2 | 0.04 | 0.04 | lasso | 1 | 0.04 | 7.7e-13 | 5.7 | -5.7 | 1.4e-08 | -0.06 | 0.02 | 0.98 | FALSE |
| 19 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C3orf10 | 0.01 | 0.01 | blup | 49 | 0.01 | 9.4e-03 | 4.9 | -5.2 | 1.7e-07 | 0.02 | 0.04 | 0.63 | FALSE |
| 20 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C3orf10 | 0.03 | 0.05 | lasso | 5 | 0.04 | 3.4e-05 | 5.2 | -5.2 | 1.6e-07 | -0.01 | 0.03 | 0.96 | FALSE |
| 21 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C3orf10 | 0.05 | 0.04 | lasso | 3 | 0.04 | 1.4e-03 | 5.0 | -5.2 | 2.6e-07 | 0.02 | 0.05 | 0.82 | FALSE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CIDECP | 0.04 | 0.02 | blup | 33 | 0.03 | 3.8e-04 | 5.1 | 5.5 | 3.0e-08 | 0.00 | 0.05 | 0.90 | FALSE |
| 23 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC401052 | 0.06 | 0.07 | enet | 6 | 0.06 | 3.5e-07 | 5.7 | -5.7 | 1.1e-08 | -0.05 | 0.01 | 0.99 | FALSE |
| 24 | The Cancer Genome Atlas | Thyroid Carcinoma | C3orf10 | 0.05 | 0.02 | blup | 49 | 0.04 | 9.3e-05 | 5.0 | -5.2 | 2.2e-07 | -0.03 | 0.04 | 0.95 | FALSE |